JP7200933B2 - dentifrice composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to an alkyl sulfate-containing dentifrice composition that has an excellent oral biofilm-removing effect and provides a good feeling when used.

As a chemical plaque (dental plaque) removal method, a method using an enzyme such as glucanase or protease that decomposes glucan or protein in plaque has been developed (Patent Documents 1 to 4; JP-A-60-38327). , JP-A-61-277632, JP-A-62-195320, JP-A-2002-187829). However, there is still room for improvement in its effects, and the prevalence of both dental caries and periodontal disease remains high.

In addition, oral compositions generally contain a surfactant, and the surfactant has a cleaning action and a penetrating action, but the single use of the surfactant has a sufficient plaque or biofilm removal effect. It was hard to say.
Therefore, the applicant has developed a new biofilm removing agent using α-olefin sulfonate or alkylsulfoacetate for the purpose of enhancing the biofilm removal effect. /008824, No. 2015/008823, Japanese Patent Laid-Open No. 2015-20970). According to the above study, as shown in the comparative example, alkyl sulfates have a low biofilm removal effect and have problems for biofilm removal applications, but alkyl sulfates are useful for dentifrice compositions. Since it is an excellent foaming component, it has been desired to develop an effective means for removing biofilms using this.

On the other hand, Patent Document 8 (Japanese Patent Application Laid-Open No. 2002-104945) discloses a hydrogen carbonate and a condensed phosphate as a dentifrice composition that uses a hydrogen carbonate and a condensed phosphate to improve the cleaning property of the dentifrice composition. A dentifrice composition that can efficiently remove tongue coating by blending in an appropriate amount and ratio. A dentifrice composition with high cleaning power is proposed by using condensed phosphate, hydrogen carbonate or hydrogen sulfate together with this as an agent, and compositions containing alkyl sulfates such as sodium lauryl sulfate are also disclosed. It is However, although it is known that hydrogen carbonates and condensed phosphates have the effect of removing tooth stains, it is currently not recognized that they have a sufficient biofilm removal effect when used alone. Patent Documents 8 and 9 do not mention the biofilm removal effect and are unclear.

JP-A-60-38327 JP-A-61-277632 JP-A-62-195320 JP-A-2002-187829 WO2015/008824 WO2015/008823 Japanese Patent Application Laid-Open No. 2015-20970 JP-A-2002-104945 JP-A-2001-89338

The present invention has been made in view of the above circumstances, and an object of the present invention is to provide an alkyl sulfate-containing dentifrice composition that has an excellent effect of removing oral biofilms and has a good feel when used.

In order to achieve the above object, the present inventors have conducted intensive studies on effective means for removing oral biofilms using alkyl sulfates while ensuring a good feeling of use. When the above is blended, the bicarbonate and condensed phosphate are blended in a specific amount or more, and the nonionic surfactant and amphoteric surfactant are blended in a specific amount or less, the biofilm removal power is improved and expressed. However, it has an excellent effect of dispersing and removing biofilm, and therefore, by combining these as an oral biofilm remover, by blending it in an oral composition, especially a dentifrice composition, an alkyl sulfate-containing system The present inventors have found that it is possible to provide an excellent biofilm removal effect in , and also to provide a good feeling of cleaning and a feeling of use (no discomfort and irritation), and have completed the present invention.

As described above, the alkyl sulfate does not have a high biofilm removing power, and on the other hand, although the foaming property increases as the amount is increased, the foaming property is deteriorated, and irritation and taste may be deteriorated. In addition, bicarbonate and condensed phosphate do not have a sufficient biofilm removal effect when used alone. However, according to the present invention, when (A) a relatively large amount of alkyl sulfate is blended, the following components (B) and (C) are used in combination, and (D) and (E) are combined, When the amounts of the components (B), (C), (D) and (E) are within specific ranges, the biofilm removal power is unexpectedly enhanced, and the oral cavity, especially the tooth surface or the tongue is built and attached. It has a biofilm removal effect that effectively disperses and removes the biofilm that has accumulated in the mouth, and the foam performance is improved, giving a satisfying cleaning experience (after rinsing the oral cavity with water, the oral cavity is clean and does not feel uncomfortable). The feeling of being washed is given, and discomfort and stimulation are suppressed, and the feeling of use is also good. In the present invention, the combination of the five components (A) to (E) provides the above-mentioned special action and effect. As shown in the comparative examples below, even if the component (A) is contained in a specific amount or more, if any of the components (B), (C), (D) and (E) is lacking, or these four components Even if it contains, if any amount is inappropriate, the effect of the present invention is inferior.

Accordingly, the present invention provides the following dentifrice composition.
[1]
(A) alkyl sulfate 1.4 to 2.5% by mass,
(B) hydrogen carbonate 0.1 to 5% by mass,
(C) condensed phosphate 0.1 to 5% by mass,
(D) nonionic surfactant 0.1 to 1.0% by mass
and (E) amphoteric surfactant 0.03 to 0.3% by mass
A dentifrice composition containing
[2]
(D) The nonionic surfactant is a polyoxyethylene hydrogenated castor oil having an average added mole number of ethylene oxide of 10 to 60 and an average added mole number of ethylene oxide of 2 to 25 and an alkyl group having 12 to 12 carbon atoms. The dentifrice composition according to [1], which is at least one selected from polyoxyethylene alkyl ethers represented by 18.
[3]
(E) The dentifrice composition according to [1] or [2], wherein the amphoteric surfactant is one or more selected from fatty acid amidopropyl betaine and fatty acid imidazolinium betaine.
[4]
The dentifrice composition according to any one of [1] to [3], which is for biofilm removal.
[5]
The dentifrice composition according to any one of [1] to [4], further comprising (F) 8 to 70% by mass of an abrasive.

ADVANTAGE OF THE INVENTION According to this invention, the biofilm removal effect is excellent, and it can provide the alkylsulfate containing dentifrice composition which gives a favorable feeling of washing and feeling of use.

The present invention will be described in further detail below. The dentifrice composition of the present invention contains (A) an alkyl sulfate, (B) a hydrogen carbonate, (C) a condensed phosphate, (D) a nonionic surfactant and (E) an amphoteric surfactant. .

(A) Alkyl sulfate preferably has an alkyl group with 12 to 16 carbon atoms, and its salt is an alkali metal salt such as sodium salt. Specifically, sodium lauryl sulfate, sodium myristyl sulfate, and the like can be used.

(B) Sodium hydrogen carbonate can be used as hydrogen carbonate.

(C) Condensed phosphates are pyrophosphates, polyphosphates, hexametaphosphates and the like, and the salts thereof are alkali metal salts such as sodium salts. Specific examples thereof include sodium pyrophosphate, sodium polyphosphate, sodium hexametaphosphate, etc. Among them, sodium pyrophosphate and sodium polyphosphate are preferable.

(D) Nonionic surfactants include, for example, polyoxyethylene hydrogenated castor oil; polyoxyethylene fatty acid ester; polyglycerol fatty acid ester; sucrose fatty acid ester such as maltose fatty acid ester; maltitol fatty acid ester, lactitol fatty acid ester, etc. sugar alcohol fatty acid ester; alkylolamide; polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monostearate; fatty acid diethanolamide such as lauric acid mono or diethanolamide; sorbitan fatty acid ester; oxyethylene higher alcohol ethers; polyoxyethylene-polyoxypropylene copolymers; and polyoxyethylene-polyoxypropylene fatty acid esters. These may be used singly or in combination of two or more. Among them, polyoxyethylene hydrogenated castor oil and polyoxyethylene alkyl ether are preferable.

The average number of added moles of ethylene oxide (hereinafter abbreviated as E.O.) in the polyoxyethylene hydrogenated castor oil is preferably 10-60.
E. of polyoxyethylene alkyl ethers. O. is preferably 2 to 25, and the number of carbon atoms in the alkyl group is preferably 12 to 18.

(E) Amphoteric surfactants include, for example, fatty acid amidopropyl betaine such as cocamidopropyl betaine; alkyl betaine such as lauryldimethylaminoacetate betaine; and fatty acid imidazolium betaine such as coconut oil fatty acid imidazolium betaine. Among them, fatty acid amidopropyl betaine and fatty acid imidazolium betaine are preferable.

In the present invention, components (A), (B), (C), (D) and (E) are combined in appropriate amounts as an oral biofilm remover, and particularly blended in a dentifrice composition.

In this case, the amount of (A) the alkyl sulfate compounded is 1.4% (mass%, hereinafter the same) or more, preferably 1.4 to 2.5%, and more preferably 1.4% (mass%) of the total composition. 4-2%. If it is less than 1.4%, the biofilm removal power is inferior. If too much is blended, discomfort and stimulation in the oral cavity may become strong, and if it is 2.5% or less, discomfort and irritation can be sufficiently suppressed.

(B) The content of hydrogen carbonate is 0.1% or more, preferably 0.1 to 5%, more preferably 0.2 to 3%, based on the total composition. If the blending amount is less than 0.1%, the biofilm-removing power is poor, and a sufficient feeling of cleansing cannot be obtained. If it exceeds 5%, discomfort and stimulation in the oral cavity cannot be sufficiently suppressed.

(C) The content of the condensed phosphate is 0.1% or more, preferably 0.1 to 5%, more preferably 0.5 to 3%, of the total composition. If the blending amount is less than 0.1%, the biofilm-removing power is poor, and a sufficient feeling of cleansing cannot be obtained. If it exceeds 5%, discomfort and stimulation in the oral cavity cannot be sufficiently suppressed.

The amount of (D) nonionic surfactant is 1% or less of the total composition, preferably 0.1 to 1.0%, more preferably 0.1 to 0.5%. If the blending amount exceeds 1%, the biofilm removal power decreases. If the content is less than 0.1%, a sufficient feeling of cleansing cannot be obtained, and discomfort and irritation in the oral cavity may not be sufficiently suppressed.

(E) The amount of the amphoteric surfactant is 0.3% or less, preferably 0.03 to 0.3%, more preferably 0.06 to 0.18%, based on the total composition. If the blending amount exceeds 0.3%, the biofilm removal power decreases. If the content is less than 0.03%, a sufficient feeling of cleansing cannot be obtained, and discomfort and stimulation in the oral cavity may not be sufficiently suppressed. In addition, the said compounding quantity is a pure quantity of an amphoteric surfactant.

The dentifrice composition of the present invention can be prepared as a toothpaste, a liquid toothpaste such as a liquid toothpaste, a wet toothpaste, etc., but the toothpaste is particularly suitable. In addition to the above components, the dentifrice composition may optionally contain other commonly used known components in addition to the above components, depending on its dosage form and purpose of use, as long as the effects of the present invention are not impaired. can. Optional ingredients that can be blended include abrasives, binders, wetting agents, sweeteners, fragrances, pH adjusters, preservatives, and medicinal ingredients.

In the present invention, surfactants other than components (A), (D) and (E) may be blended as long as they do not interfere with the effects of the present invention. may
Specifically, anionic surfactants other than component (A) include α-olefin sulfonate, hydrogenated coconut fatty acid monoglyceride monosulfate, lauryl sulfoacetate, N-methyl-N-acyl taurine, and the like. N-acyl taurate; acyl amino acid salts such as acyl sarcosinate and N-acyl-L-glutamate. These can be used alone or in combination of two or more. When these anionic surfactants are blended, the blending amount thereof is preferably 1.4 to 5%, more preferably, the total amount of the total amount of the composition combined with the blending amount of component (A). 1.4 to 3%. Anionic surfactants other than component (A) may be added at 0% without blending.

The abrasive, especially precipitated silica, is preferably abrasive particles having a particle size of 1-40 μm and a BET specific surface area of 80-250 square meters per gram. The particle size is a value measured by a particle size distribution analyzer (Microtrac particle size distribution meter manufactured by Nikkiso Co., Ltd., dispersion medium: water).
As such silica-based abrasives, commercially available products can be used. Co., Ltd. zirconosilicate, aluminosilicate and the like.

Also, the abrasive may be in the form of granules, and granules can be blended as a component having abrasive properties. The granules are particles obtained by forming water-insoluble powder into granules, and granulation using a binder may be used for granulation.
The compounding amount of the abrasive is preferably 8 to 70%, particularly 10 to 50% of the total composition.

Binders include xanthan gum, sodium polyacrylate, sodium alginate, sodium carboxymethylcellulose, polyvinylpyrrolidone, carrageenan, methylcellulose, sodium hydroxyethylcellulose, tragacanth gum, karaya gum, arabic gum, locust bean gum, polyvinyl alcohol, carboxyvinyl polymer, carbopol. , Veegum and propylene glycol alginate, and inorganic binders such as thickening silica and aluminum silicate. These can be used alone or in combination of two or more. The blending amount of these binders is preferably 0.8 to 5%, particularly preferably 1 to 3%, of the total composition in the case of an organic binder, and 0.5 to 0.5% of the total composition in the case of an inorganic binder. 10%, especially 1 to 8% is preferred.

Wetting agents include polyhydric alcohols such as sorbitol, glycerin, propylene glycol, polyethylene glycol having an average molecular weight of 200 to 6,000, ethylene glycol, 1,3-butylene glycol, erythritol, trimethylglycine, and reduced starch saccharification products. sugar alcohols. The blending amount of these wetting agents is preferably 10 to 70% of the total composition.

Sweeteners include sodium saccharin, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartine, glycyrrhizin, thaumatin, asparatylphenylalanine methyl ester and the like.
Flavoring agents include known fragrances such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineol, linalool, ethyllinalool, vanillin, thymol, spearmint oil, peppermint oil. , lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, eucalyptus oil and the like.
Examples of pH adjusters include organic acids such as citric acid and lactic acid, salts thereof, and inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.
Preservatives include paraoxybenzoic acid esters, sodium benzoate and the like.

Medicinal ingredients include enzymes such as dextranase, amylase, protease, and mutanase; anti-inflammatory agents such as tranexamic acid, epsilon-aminocaproic acid, azulene, glycyrrhizinate, and glycyrrhizinate; sodium chloride, vitamins, allantoins, etc. bactericidal agents such as isopropylmethylphenol, cetylpyridinium chloride, benzalkonium chloride, hinokitiol, and lysozyme chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; anticalculus agents such as zeolite; vitamin E, etc. blood circulation promoter; amino acids such as alanine, glycine, and proline can be blended. In addition, the compounding amount of the medicinal component can be an effective amount within a range that does not impair the effects of the present invention.

Furthermore, as optional ingredients, inorganic compounds such as mica titanium, titanium oxide, and bentonite; cellulose-based organic powders such as crystalline cellulose; natural polymer compounds such as agar, gelatin, starch, and glucomannan; polyvinyl acetate, and acrylic resins. , synthetic polymer compounds such as polyurethane, polyester, polyvinyl chloride, nylon powder, polyethylene powder, or copolymers thereof; waxes such as carnauba wax, rosin, rice wax, microcrystalline wax, beeswax, paraffin wax; cetanol, Higher alcohols such as stearyl alcohol; polyisobutylene, polybutadiene, silicone, natural rubber, etc. can be blended as long as the effects of the present invention are not impaired.

EXAMPLES The present invention will be specifically described below by showing Examples, Comparative Examples, and Formulation Examples, but the present invention is not limited to the following Examples. In the following examples, % indicates % by mass unless otherwise specified.

[Examples, Comparative Examples]
Dentifrice compositions having compositions shown in Tables 1 to 4 were each prepared by a conventional method and placed in a conventional laminated tube container. These were used as samples and evaluated by the methods described below. The results are also shown in Tables 1-4.

Experiment 1: Evaluation method of biofilm removal ability Fusobacterium nucleatum (F.n.), Streptococcus soprinus (S.s), and Actinomyces viscosus (A.v.) bacteria cultured in BM medium were centrifuged. After harvesting, the cells were suspended in BM medium to OD550=1. A final concentration of F.I. n. is 6%, S.E. s. is 1%, A. v. Each bacterial solution diluted with BM medium and mixed to 14% was seeded in a 24-well plate and cultured under anaerobic conditions for 24 hours to form a biofilm. After removing the medium, the biofilm was washed with PBS (phosphate buffered saline), a sample diluted 3-fold with purified water was added, and left to stand for 3 minutes. Then, after washing with PBS, 250 μl of PBS was added, and the remaining biofilm was recovered using a pipette. The OD550 of the collected liquid was measured to measure the amount of biofilm.
In addition, the amount of biofilm was measured in the same manner as above for those treated with PBS instead of the sample, and used as a blank.
The ratio (%) of the biofilm amount of the sample to the blank was calculated, and the biofilm removal power was evaluated according to the following criteria to determine the biofilm removal effect.
Evaluation criteria ◎: The amount of biofilm decreased by 20% or more compared to the blank ○: The amount of biofilm decreased by 10% or more and less than 20% compared to the blank ×: The amount of biofilm decreased compared to the blank was less than 10%

Experiment 2: Method for evaluating stimulating feeling during use, feeling of cleansing after use, and discomfort after use Evaluation was carried out by four subjects.
1 g of the sample was placed on a toothbrush (clinica advantage toothbrush, 4-row compact regular type, manufactured by Lion Corporation) and brushed the teeth for 3 minutes. Irritation during use, feeling of cleansing after use, and discomfort after use were evaluated according to the following rating criteria. The average value of 4 people was obtained and evaluated according to the following evaluation criteria.
Here, the feeling of cleansing after use is the feeling that the oral cavity is cleanly cleaned without discomfort after using and rinsing the oral cavity with water. The sense of discomfort after use is a feeling that the oral cavity is stiff or tense after rinsing. The sensation of irritation during use is an unpleasant sensation of stimulation felt in the oral cavity during use.

<Stimulation during use>
Rating criteria 5: Did not feel stimulation 4: Almost did not feel stimulation 3: Slightly felt stimulation, but at a level that was not problematic 2: Stimulated 1: Very stimulated Evaluation criteria ◎: 4 Average score of 4 people or more ○: Average score of 4 people is 3 points or more and less than 4 points △: Average score of 4 people is 2 points or more and less than 3 points ×: Average score of 4 people is less than 2 points

<Cleaning experience after use>
Rating criteria 5: Very good 4: Good 3: Somewhat good 2: Not good 1: Very bad Evaluation criteria ◎: Average score of 4 people is 4 points or more ○: Average score of 4 people is 3 points or more 4 points Less than △: Average score of 4 people is 2 or more and less than 3 ×: Average score of 4 people is less than 2 points

<Discomfort after use>
Rating criteria 5: Not felt 4: Hardly felt 3: Somewhat felt 2: Sensed 1: Strongly felt Evaluation criteria ◎: Average score of 4 people is 4.5 points or more ○: Average score of 4 people is 4 points or more Less than 5 points △: Average score of 4 people is 3 points or more and less than 4 points ×: Average score of 4 people is less than 3 points

A formulation example is shown below. In addition, Table 5 below shows the results of evaluating the dentifrice compositions of Formulation Examples in the same manner as described above.

[Prescription example 1]
(A) sodium lauryl sulfate 1.8
(B) Sodium bicarbonate 0.5
(C) sodium pyrophosphate 0.5
(D) polyoxyethylene (5) stearyl ether 1
(E) coconut oil fatty acid amidopropyl betaine liquid (30%) 1
(Pure amount 0.3%)
(F) abrasive silica 20
Carboxymethylcellulose sodium 1.4
Propylene glycol 3
Sorbit solution (70%) 35
Saccharin sodium 0.18
Sodium fluoride 0.2
Thickening silica 6
Titanium oxide 0.5
Evercool-180 ^* 0.001
Perfume A 1
Purified water residue
Total 100%
*Evercool-180; Evercool 180, cooling agent, Givaudan Japan Co., Ltd. N-(4-cyanomethylphenyl)-2-isopropyl-5-methylcyclohexanecarboxamide

[Prescription Example 2]
(A) sodium lauryl sulfate 1.4
(B) Sodium bicarbonate 0.3
(C) sodium pyrophosphate 1
(D) Polyoxyethylene (60) hydrogenated castor oil 0.3
(E) coconut oil fatty acid amidopropyl betaine liquid (30%) 1
(Pure amount 0.3%)
(F) abrasive silica 15
Xanthan gum 0.3
Sodium polyacrylate 0.5
Sorbit solution (70%) 50
Propylene glycol 5
Saccharin sodium 0.15
Sodium fluoride 0.2
sodium hydroxide 0.1
Mica Titanium 0.04
Evercool-180 ^* 0.001
Perfume A 1
Purified water residue
Total 100%

[Prescription Example 3]
(A) sodium lauryl sulfate 2
(B) Sodium bicarbonate 0.3
(C) sodium hexametaphosphate 0.5
(D) Polyoxyethylene (20) hydrogenated castor oil 0.5
(E) coconut oil fatty acid imidazolium betaine solution (30%) 0.3
(pure amount 0.09%)
(F) abrasive silica 8
Carboxymethylcellulose sodium 1.5
Propylene glycol 2.5
Sorbit solution (70%) 25
Saccharin sodium 0.05
Sodium monofluorophosphate 0.2
Thickening silica 8
Evercool-180 ^* 0.001
Perfume A 1
Purified water residue
Total 100%

[Prescription Example 4]
(A) sodium myristyl sulfate 1.5
(B) Sodium bicarbonate 0.3
(C) sodium polyphosphate 1
(D) Decaglycerin fatty acid ester 0.5
(E) coconut oil fatty acid amidopropyl betaine liquid (30%) 0.5
(pure amount 0.15%)
(F) abrasive silica 20
Xanthan gum 0.6
Sodium alginate 0.3
Sodium polyacrylate 0.3
Propylene glycol 3
Sorbit liquid (70%) 40
Saccharin sodium 0.18
Sodium fluoride 0.3
Thickening silica 2
Titanium oxide 0.5
Evercool-180 ^* 0.0001
Perfume A 1
Purified water residue
Total 100%

[Prescription Example 5]
(A) sodium lauryl sulfate 2
(B) Sodium bicarbonate 1
(C) sodium polyphosphate 1
(D) Polyoxyethylene (20) cetyl ether 0.5
(D) Polyoxyethylene (20) hydrogenated castor oil 0.5
(E) coconut oil fatty acid amidopropyl betaine liquid (30%) 0.5
(pure amount 0.15%)
(F) abrasive silica 15
Xanthan gum 1.5
Sodium polyacrylate 0.3
Propylene glycol 4
Sorbit solution (70%) 25
Saccharin sodium 0.2
Sodium fluoride 0.2
Thickening silica 2
Titanium oxide 0.4
Evercool-180 ^* 0.0003
Perfume A 1
Purified water residue
Total 100%

Tables 6 to 14 show the compositions of perfume A and perfumes B to P used in the above examples and formulation examples. Dentifrice compositions were prepared by replacing perfume A in the above Examples and Formulation Examples with perfumes B to P, respectively, and evaluated in the same manner.

Claims (4)

(A) alkyl sulfate 1.4 to 2 % by mass,
(B) 0.2 to 3 % by mass of hydrogen carbonate,
(C) 0.5 to 3 % by mass of condensed phosphate,
(D) Polyoxyethylene hydrogenated castor oil as a nonionic surfactant
0.1 to 0.5 % by mass
and (E) 0.06 to 0.18 % by mass of fatty acid amidopropyl betaine as an amphoteric surfactant
A dentifrice composition containing 2. The dentifrice composition according to claim 1 , wherein the polyoxyethylene hydrogenated castor oil has an average number of added moles of ethylene oxide of 10-60. The dentifrice composition according to claim 1 or 2 , which is for oral biofilm removal. The dentifrice composition according to any one of claims 1 to 3 , further comprising (F) 8 to 70% by mass of an abrasive.