JP7206635B2 - External agent for lips - Google Patents

Description

TECHNICAL FIELD The present invention relates to an external preparation for the lips, and more specifically to an external preparation for the lips for improving the color of the lips.

Red lips are known to make women look attractive (Non-Patent Document 1), and there is a high demand for producing red lips. Therefore, there are many products on the market, such as make-up cosmetics and other cosmetics containing pigments, which correct the appearance of color. On the other hand, it is also desired to improve the color of the lips themselves without relying on make-up. There are also cosmetics in the market that contain ingredients that can be expected to However, many consumers say that existing beauty methods and cosmetics do not provide satisfactory results, and a more effective technique for improving lip redness is in demand.

One of the elements of the color of the lips is redness due to blood. Therefore, cosmetic formulations containing ingredients that promote blood circulation, such as capsaicin, have been put on the market, with the intention of imparting a healthy and youthful impression by making the lips moderately red due to their effect of promoting blood circulation. However, sufficient effects are not obtained, lips are irritated during use, and consumers are not satisfied, and new techniques for improving the color of the lips are still desired.

Stephen ID, McKeegan AM. Perception. 2010;39(8):1104-1110.

An object of the present invention is to provide an external preparation for lips that improves the red color of the lips themselves.

As a result of intensive research, the present inventors came up with the idea of increasing the number of blood vessels in the lips in order to improve the color of the lips due to the redness caused by blood. Then, they came up with the idea of adding a component that increases blood vessels, that is, promotes angiogenesis to an external preparation for the lips, and completed the present invention.

That is, the present invention is as follows.
[1] An external lip preparation for improving color, containing an angiogenesis promoter.
[2] The angiogenesis-promoting agent contains one or more selected from the group consisting of Sohakuhi extract, Opuntia ficus-indica extract, morning glory extract, and gentian extract, The external preparation for lips according to [1].
[3] The external preparation for lips according to [1] or [2], further comprising a blood circulation promoter.
[4] The external preparation for lips according to [3], wherein the blood circulation promoting agent contains Sichuan pepper extract.
[5] An external lip preparation for improving color, containing an extract of Sohakuhi and a Sichuan pepper extract.
[6] The external preparation for lips according to any one of [1] to [5], which is a cosmetic or quasi-drug.

INDUSTRIAL APPLICABILITY According to the present invention, there is provided an external preparation for lips that can improve the reddish color of the lips themselves without causing irritation. The external preparation for lips is suitable for cosmetics and the like, and can produce healthy and attractive lips.

Graph showing the luminal length of cultured human vascular endothelial cells (*: p<0.05, **: p<0.01). Graph showing the spatial area between lumens of cultured human vascular endothelial cells (*: p<0.05, **: p<0.01). Graph showing the amount of change in the hemoglobin value of the lips (*: p<0.05, **: p<0.01, N.S.: no significant difference).

The external preparation for lips of the present invention contains an angiogenesis promoter.
Angiogenesis is a physiological phenomenon in which new blood vessels are formed from pre-existing blood vessels. An angiogenesis-promoting agent refers to an agent that promotes the formation of blood vessels.
Angiogenesis can be confirmed by evaluating lumen formation, in which vascular endothelial cells aggregate and adhere to form the original morphology of blood vessels (Arnaautova I, Kleinman HK. Nat Protoc. 2010; 5(4) ): 628-35.). That is, the length of the connection between vascular endothelial cells cultured on the matrix and/or the area of the space formed as a result of the connection between the vascular endothelial cells is used as an indicator to promote or suppress angiogenesis. Ingredients with action can be evaluated.

In the present invention, the angiogenesis-promoting agent is not particularly limited, but preferably includes a sohakuhi extract, an Opuntia Ficus indica extract, a morning glory extract, and a gentian extract, and one or two selected from the group consisting of More than one species can be used.
It should be noted that gentian extracts and morning glory extracts are known to have angiogenesis-promoting action, and have been proposed to be added to skin preparations for external use to improve rough skin and nourish hair (Japanese Unexamined Patent Application Publication No. 2000- 212059, Japanese Patent Laid-Open No. 2003-160503). In addition, the inventors of the present invention have newly found that the Souhakuhi extract and the Opuntia Ficus indica extract have an angiogenesis-promoting action, as shown in the experimental results described later.

The content of the angiogenesis promoting agent in the external preparation for lips of the present invention is preferably 0.001% to 10% by mass, more preferably 0.005 to 5% by mass, based on the total amount of the external preparation composition. More preferably, when the content is 0.01 to 0.1% by mass, the desired effect can be easily obtained, and the degree of freedom in prescription design can be ensured.

The external preparation for lips of the present invention preferably further contains a blood circulation promoting agent.
Promoting blood circulation means increasing blood flow. A blood circulation-promoting agent refers to an agent that has the effect of increasing blood flow.
In the present invention, the blood circulation-promoting agent is not particularly limited , but preferably includes Sichuan pepper extract, which is known to have a blood circulation-promoting effect. In addition, capsaicin is also a component known to have a blood circulation-promoting effect, and a capsicum tincture extract containing this can also be used as a blood circulation-promoting agent. is contained in a very small amount, for example, 0.0001% by mass or less with respect to the total amount of the external preparation, or preferably not contained.

The total content of the blood circulation promoting agent in the external preparation for lips of the present invention is preferably 0.001 to 10% by mass, more preferably 0.005 to 5% by mass, and still more preferably 0%, based on the total amount of the external preparation. When the content is 0.01 to 0.1% by mass, the desired effect can be easily obtained, and the degree of freedom in prescription design can be ensured.

In the external preparation for lips of the present invention, the content of the angiogenesis-promoting agent and the blood circulation-promoting agent is preferably 1:5 to 5:1, more preferably 1:2 to 2:1, in mass ratio, It is easy to obtain the desired effect.

Another aspect of the present invention is a color-enhancing lip preparation for external use, which contains an extract of Sohakuhi and a Sichuan pepper extract.
In this embodiment, the total amount of the extract of sargassum extract is preferably 0.001% to 10% by mass, more preferably 0.005 to 5% by mass, and still more preferably 0.01%, based on the total amount of the composition for external use. When the content is up to 0.1% by mass, the desired effect can be easily obtained, and the degree of freedom in prescription design can be ensured. In addition, the total content of the Sichuan pepper extract is preferably 0.001% to 10% by mass, more preferably 0.005 to 5% by mass, and still more preferably 0.01 to 0%, based on the total amount of the composition for external use. When the content is 1% by mass, the desired effects can be easily obtained, and the degree of freedom in prescription design can be ensured. Moreover, the content of the sourdough extract and the Sichuan pepper extract is preferably 1:5 to 5:1, more preferably 1:2 to 2:1 in mass ratio, so that the desired effect can be easily obtained.

The external preparation for lips of the present invention can increase the blood volume of the lips by angiogenic action and increase the appearance of redness due to hemoglobin in the blood. As a result, the lips themselves can be brought to a complex, natural reddish, and healthy color, which is suitable for improving the color.
In addition, as shown in the test examples described later, the topical preparation of the present invention is less likely to cause irritation during use, and can therefore be suitably applied to the lips, which generally have thin skin.

Formulations of the external preparation for the lips of the present invention include lotions, emulsifiers such as milky lotions and creams, oil formulations, gel formulations, packs, cleansers and the like.
The form of the external preparation is not particularly limited, but preferably includes cosmetics and quasi-drugs, and is suitable for products such as lipstick, lip balm, and lip gloss.

In addition to the components described above, the external preparation for lips of the present invention can contain a wide range of components commonly used in cosmetics and quasi-drugs. Examples of such ingredients include, but are not limited to, various active ingredients, oily ingredients, surfactants, polyhydric alcohols, thickeners, powders, ultraviolet absorbers, and the like.

Active ingredients include whitening ingredients, wrinkle-improving ingredients, anti-inflammatory ingredients, extracts derived from other animals and plants, and the like.
The whitening component is not particularly limited as long as it is commonly used in cosmetics. For example, 4-n-butylresorcinol, ascorbic acid glucoside, 3-O-ethylascorbic acid, tranexamic acid, arbutin, ellagic acid, kojic acid, linoleic acid, nicotinamide, 5,5′-dipropylbiphenyl-2, 2'-diol, disodium 5'-adenylate, cetyl tranexamate, potassium 4-methoxysalicylate, hydroquinone, pantothenic acid and the like.
The content of the whitening component in the cosmetic is usually 0.01 to 30% by mass, preferably 0.1 to 10% by mass, more preferably 0.3 to 5% by mass.

The wrinkle-improving component is not particularly limited as long as it is commonly used in cosmetics. For example, sodium trifluoride isopropyloxopropylaminocarbonylpyrrolidinecarbonylmethylpropylaminocarbonylbenzoylaminoacetate, nicotinamide, vitamin A or derivatives thereof (retinol, retinal, retinoic acid, tretinoin, isotretinoin, tocopherol retinoate, retinol palmitate , retinol acetate, etc.), benzyl ursolic acid, ursolic acid phosphate, betulinic acid benzyl ester, and benzylic acid phosphate.
The content of the wrinkle-improving component in the external preparation is usually 0.01 to 30% by mass, preferably 0.1 to 10% by mass, more preferably 1 to 5% by mass.

Anti-inflammatory components include glycyrrhizic acid, glycyrrhetinic acid, allantoin, isopropylmethylphenol, clarinon, glabridin, salicylic acid, tocopherol acetate, tocopherol nicotinate, tranexamic acid, nicotinamide, pantothenic acid, pantothenyl alcohol, and these Examples thereof include salts, derivatives, etc., and preferred are glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, tranexamic acid and its derivatives, pantothenyl alcohol and pantothenic acid and its salts.
The content of the anti-inflammatory component in the external preparation is usually 0.01 to 30% by mass, preferably 0.1 to 10% by mass, more preferably 1 to 5% by mass.

Other extracts derived from animals and plants are not particularly limited as long as they are commonly used in cosmetics and the like. For example, akebi extract, asunaro extract, asparagus extract, avocado extract, amacha extract, almond extract, arnica extract, aloe extract, aronia extract, apricot extract, ginkgo biloba extract, Indian mushroom extract, fennel extract, udo extract, ageitsu extract, eleuthero extract , Trillium extract, Scutellaria root extract, Phellodendron extract, Coptis extract, Panax ginseng extract, Hypericum extract, Dead nettle extract, Orange extract, Kakyoku extract, Kakon extract, Chamomilla extract, Carrot extract, Kawara mugwort extract, Kiwi extract, Cucumber extract, Guava extract, Kujin extract, gardenia extract, kumazasa extract, clara extract, walnut extract, grapefruit extract, black rice extract, chlorella extract, mulberry extract, turmeric extract, gentian extract, gentian extract, gennoshoko extract, black tea extract, burdock extract, rice extract, fermented rice extract , rice bran fermented extract, rice germ oil, lingonberry extract, salvia extract, soapwort extract, sasa extract, hawthorn extract, sansha extract, Japanese pepper extract, shiitake extract, rhododendron extract, rhizome extract, perilla extract, linden extract, meadowsweet extract, peony extract, pepper Kyou extract, calamus root extract, white birch extract, horsetail extract, stevia extract, fermented stevia, ivy extract, hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, cnidium extract, assembly Extract, Sohakuhi extract, Rheum extract, Soybean extract, Taisou extract, Thyme extract, Dandelion extract, Tea extract, Clove extract, Chimp extract, Tencha extract, Capsicum extract, Angelica extract, Angelica extract, Calendula officinalis extract, Tonin extract, Spruce extract, Houttuynia cordata extract, Tomato extract , natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bakumondou extract, lotus extract, parsley extract, birch extract, hamamelis extract, cypress extract, cypress extract, loquat extract, coltsfoot extract, coltsfoot extract, bukuryo extract, butcher bloom extract, grape extract, grape seed extract, luffa extract, safflower extract, peppermint extract, bodaiju extract, Botan extract, hop extract, pine extract, mayonara extract, horse chestnut extract, skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, yokuinin extract, mugwort extract, lavender extract, green tea Extracts such as apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, burnet extract are preferred.
The content of the animal or plant-derived extract in the external preparation is usually 0.01 to 30% by mass, preferably 0.1 to 10% by mass, more preferably 1 to 5% by mass.

Polar oil, volatile hydrocarbon oil, etc. are mentioned as an oily component.
Polar oils include synthetic ester oils such as isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, and lactic acid. Cetyl, myristyl lactate, lanolin acetate, 2-ethylhexyl isononanoate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, monoisostearate N- Alkyl glycol, neopentyl glycol dicaprate, diisostearyl malate, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentane tetra-2-ethylhexanoate Mention may be made of erythritol, glyceryl tri-2-ethylhexanoate, trimethylolpropane triisostearate.

In addition, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptyl undecanoic acid glyceride, castor oil fatty acid methyl ester, oleic oil, cetostearyl alcohol, acetoglyceride, palmitic acid 2 -heptylundecyl, diisobutyl adipate, N-lauroyl-L-glutamic acid 2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyl myristate Decyl, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, octyl methoxycinnamate and the like.

In addition, as natural oils, avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, Safflower oil, cottonseed oil, perilla oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, sinagiri oil, Japanese pungent oil, jojoba oil, germ oil, triglycerin, glyceryl trioctanoate, glyceryl triisopalmitate etc.

Volatile hydrocarbon oils include isododecane, isohexadecane, and the like.

Surfactants include fatty acid soaps (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, anionic surfactants such as alkyl sulfate triethanolamine ether, stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide. cationic surfactants such as betaine surfactants (alkylbetaine, amidobetaine, sulfobetaine, etc.), imidazoline amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy 2 sodium salts, etc.), amphoteric surfactants such as acylmethyl taurine,
Sorbitan fatty acid esters (sorbitan monostearate, sorbitan sesquioleate, etc.), glycerin fatty acid esters (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.), hydrogenated castor oil derivatives, glycerin alkyl Ether, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbit fatty acid esters (POE-sorbit monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin monoiso stearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE 2-octyldodecyl ether, etc.), POE alkylphenyl ethers (POE nonylphenyl ether, etc.), Pluronic types, POE/POP alkyl ethers (POE/POP 2-decyltetradecyl ether, etc.), tetronics, POE castor oil/hydrogenated castor oil derivatives (POE castor oil, POE hydrogenated castor oil, etc.), sucrose fatty acid esters, alkyl glucosides, etc. nonionic surfactants, and the like.

Polyhydric alcohols include polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4 -hexylene glycol, 1,2-hexanediol, 1,2-octanediol and the like.

Thickeners include guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin sulfate, dermatan sulfate, glycogen, Heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxyethyl guar gum, carboxymethyl guar gum, dextran, kerato sulfate, locust bean gum, succinoglucan, caroninic acid, chitin, chitosan, carboxymethyl Chitin, agar, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, sodium polyacrylate, polyethylene glycol, bentonite and the like.

As the powders, powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, anhydrous silicic acid (silica), aluminum oxide, and barium sulfate, which may be surface-treated, may be used. Inorganic pigments such as red iron oxide, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine blue, Prussian blue, titanium oxide, and zinc oxide that may be treated, mica titanium that may be treated, fish phosphorus foil, Pearl agents such as bismuth oxychloride, optionally laked Red No. 202, Red No. 228, Red No. 226, Yellow No. 4, Blue No. 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223 No., Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204 and other organic pigments, polyethylene powder, polymethyl methacrylate, nylon powder, and organic powders such as organopolysiloxane elastomers.

Examples of UV absorbers include para-aminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2-(2 UV absorbers such as '-hydroxy-5'-t-octylphenyl)benzotriazole, 4-methoxy-4'-t-butyldibenzoylmethane, and the like.

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited to the following examples as long as the gist thereof is not exceeded.

<Reference test example>
Using cultured human vascular endothelial cells (HUVEC, Takara Bio Inc.), Cultrex In Vitro Angiogenesis Assay Tube Formation Ki
Angiogenesis was induced using t (Trevigen). That is, after incorporating calcein AM attached to the kit into cultured human vascular endothelial cells and staining them with green fluorescence, they were placed on the matrix attached to the kit with one of various test substances (0.1% by volume) for 10 hours. cultured. Green fluorescence images were taken and by image analysis the length of the lumens and the spatial area between the lumens were measured and compared to vehicle controls without test article. rice field. The length of the lumen refers to the length of the cells arranged in a mesh pattern, and the space area between the lumen refers to the area of the extracellular black space formed after the cells are arranged. Lumen length and space area between lumens represent the level of lumen formation, which is an indicator of angiogenesis (Non-Patent Document 2).

The test substances are as follows.
Hawthorn extract (Ogi Pharmaceutical Co., Ltd.)
Hikiokoshi extract (Maruzen Pharmaceutical Co., Ltd.)
Sohakuhi extract (Maruzen Pharmaceutical Co., Ltd.)
Gentian extract (Ichimaru Farcos Co., Ltd.)
Morning glory extract (Maruzen Pharmaceutical Co., Ltd.)
Opuntia Ficus Indica Extract (Koei Kogyo Co., Ltd.)
Tsurureishi extract (Intron Co., Ltd.)
Acerola extract (Nichirei Biosciences, Inc.)
Green tea extract (Kouei Kogyo Co., Ltd.)
Kiwi extract (Ichimaru Farcos Co., Ltd.)
Roman chamomile extract (Koei Kogyo Co., Ltd.)

FIG. 1 shows the results of the lumen length measurements. A statistically significant luminal length increasing effect was observed in the gentian extract, the morning glory extract, and the Opuntia Ficus indica extract relative to the solvent control.
FIG. 2 shows the measurement results of the space area between the lumens. Statistically Significant Interluminal Spaces vs. Solvent Controls in Soh Hakuhi Extract, Gentian Extract, Morning Glory Extract, Opuntia Ficus Indica Extract, Momordica Extract, Kiwi Extract, and Roman Chamomile Extract An effect of increasing the area was observed.
A significant increase in both luminal length and interluminal space area was observed. Presumed to have a stimulating effect.

<Example>
The ingredients shown in Table 1 were heated to 80° C. and cooled while being stirred and mixed to produce a lip balm. Formulation 1 of the present invention contains an extract of Phyllanthus japonicum as an angiogenesis promoter, and Preparation 2 of the present invention contains an extract of Phyllanthus pertussis as an angiogenesis promoter and a Sichuan pepper extract as a blood circulation promoter. The control formulation contains neither pro-angiogenic agents nor blood circulation-promoting agents. Comparative formulation 1 does not contain an angiogenesis promoting agent, but contains red pepper tincture (including capsaicin) as a blood circulation promoting agent. Comparative preparation 2 does not contain an angiogenesis promoting agent, and contains Sichuan pepper extract as a blood circulation promoting agent.

<Test Example 1>
Each of the formulations prepared in the Examples was used by 5 subjects (25 people in total) every day for 2 weeks, and the lip hemoglobin levels before and after continuous use were compared. Specifically, an image of the lips taken using Anterra 3D (manufactured by Miravex) before continuous use and an image taken in the same way after continuous use were arranged, and on the Anterra 3D image taken before continuous use, "the entire upper and lower lips After 2 weeks of use, the analysis range was automatically matched to the image after 2 weeks of use, and data was acquired using the analysis item of the average hemoglobin level.
In this test, it is recognized that the more the hemoglobin value increases, the more effective the color of the lips, more specifically, the complexion.

The results are shown in FIG. Compared to the control formulation containing no angiogenesis-promoting agent and blood circulation-promoting agent, both formulations 1 and 2 containing an angiogenesis-promoting agent and/or blood circulation-promoting agent and comparative formulations 1 and 2 had lower hemoglobin values than before long-term use. A tendency to increase after continuous use was observed.
However, the comparison preparation 1 containing capsicum tincture as a blood circulation promoter did not show a statistically significant complexion-improving effect as compared with the solvent control, whereas the preparation containing Sahuhakuhi extract as an angiogenesis promoter. 1 showed a nearly two-fold increase in hemoglobin values over Comparative Formulation 1 with a statistically significant difference from the Control Formulation. From this, it can be seen that the lip balm containing an angiogenesis promoting agent is effective in improving the complexion of the lips.
In addition, even in comparative preparation 2, which does not contain an angiogenesis promoting agent and contains Sichuan pepper extract as a blood circulation promoting agent, the hemoglobin value was statistically significantly increased compared to the solvent control, but Sohakuhi extract as an angiogenesis promoting agent In preparation 2, which contains the hemoglobin extract and the Sichuan pepper extract as a blood circulation promoting agent, an increase in the hemoglobin value of about two times greater was observed. From this, it can be seen that a lip balm containing an angiogenesis-promoting agent and a blood circulation-promoting agent is more effective in improving the complexion of the lips.

<Test Example 2>
Each of the preparations prepared in the Examples was used by 5 subjects, a total of 25 subjects, every day for 2 weeks, and the redness of the lips before and after continuous use was compared. Specifically, photographs of the frontal face are taken before and after continuous use, and using Photoshop (Adobe Systems), an analysis area is set in the upper lip in the photograph, and the average R value of RGB in the analysis area. Values were calculated and compared.
Table 2 shows the results. Compared to the control formulation containing no angiogenesis-promoting agent and blood circulation-promoting agent, both formulations 1 and 2 containing an angiogenesis-promoting agent and/or blood circulation-promoting agent and comparative formulations 1 and 2 have R values compared to before continuous use. A tendency to increase after continuous use was observed. Of these, formulations 1 and 2, and comparative formulation 2 showed statistically significant increases over the control formulation. In particular, formulation 1, which contains the cinnamon bark extract as an angiogenesis-promoting agent, and formulation 2, which contains the cinnamon bark extract as an angiogenesis-promoting agent and the Sichuan pepper extract as a blood circulation-promoting agent, have approximately twice the R value of the comparative formulation. showed an increase in From this, it can be seen that the lip balm containing an angiogenesis-promoting agent is effective in improving the complexion of the lips, and the lip balm containing an angiogenesis-promoting agent and a blood circulation-promoting agent is more effective in improving the complexion of the lips. .

<Test Example 3>
Each of the preparations prepared in Examples was used by 5 subjects (25 people in total) every day for 2 weeks, and after continuous use, an interview was conducted as to whether or not there was irritation during use. Free answers were given to the interviews.
Table 3 shows the results. All of the subjects complained of some irritation with Comparative Formulation 1 containing chili pepper tincture as a blood circulation promoting agent, whereas Formulations 1 and 2 and Comparative Formulation 2 did not complain of irritation. From this, it can be seen that the Rhizophora chinensis extract can be suitably blended into lip balm as an angiogenesis promoting agent.

INDUSTRIAL APPLICABILITY According to the present invention, there is provided an external preparation for lips that can improve the reddish color of the lips themselves without causing irritation. The external preparation for lips is suitable for cosmetics and the like, and is industrially useful because it can produce healthy and attractive lips.

Claims (4)

0.001% by mass to 10% by mass of the total topical preparation containing an angiogenesis promoter containing one or more selected from the group consisting of Sohakuhi extract, Opuntia Ficus indica extract, morning glory extract, and gentian extract % , and 0.001% by mass to 10% by mass of a blood circulation promoting agent based on the total amount of the external preparation,
An external preparation for the lips, wherein the color improvement is to make the lips themselves complex and naturally reddish. The external preparation for lips according to claim 1 , wherein the blood circulation promoting agent contains Sichuan pepper extract. An external preparation for lips for improving color, containing 0.001% to 10% by weight of the whole topical preparation of Sohakuhi extract and 0.001% to 10% by weight of the whole topical preparation of Siberian Pepper extract. and
An external preparation for the lips, wherein the color improvement is to make the lips themselves complex and naturally reddish. The external preparation for lips according to any one of claims 1 to 3 , which is a cosmetic or a quasi-drug.

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