JP7224181B2 - skin cosmetics - Google Patents

Description

The present invention relates to skin cosmetics.

Conventionally, the effects of plant and seaweed extracts on the skin and cosmetics using them have been investigated.
For example, cloves are known to suppress the formation of CML (carboxymethyllysine: Nε-(carboxymethyl)lysine)) in the epidermis and prevent or improve epidermal aging and yellowing (Patent Document 1). .
In addition, extracts obtained from seaweed such as fucus are known to suppress the activity of elastase produced and secreted by dermal fibroblasts and prevent a decrease in skin firmness and elasticity (Patent Document 2).
Furthermore, Sambucus nigra extract is known to have a melanogenesis inhibitory effect (Patent Document 3).

JP 2017-100991 A Japanese Unexamined Patent Application Publication No. 2001-181167 JP-A-2003-104835

Clove extract and Sambucus nigra extract have the effect of suppressing yellowing of the epidermis and melanin production, and can suppress spots and the like, but are not sufficient in brightening the skin color. Furthermore, when a large amount of these extracts are blended in skin cosmetics, they tend to turn brown, and there is also the problem of stability over time.

The inventors of the present invention have been studying to develop a skin cosmetic that imparts transparency and brightness to the skin. The present inventors have found that a skin cosmetic that imparts brightness and suppresses discoloration derived from raw materials and has excellent stability over time can be obtained, and completed the present invention.

The present invention provides the following components (A), (B) and (C):
(A) clove extract,
(B) Sambucus nigra extract,
(C) contains a fucus extract, and the mass ratio of component (C) to the total amount of components (A) and (B) (in terms of solid content) (C) / ((A) + (B)) is 0 .5 to 3 for skin cosmetics.

The skin cosmetic of the present invention imparts transparency and brightness to the skin, suppresses discoloration derived from raw materials, and has excellent stability over time.

In the clove extract of component (A) used in the present invention, "choji" refers to clove (scientific name: Syzygium aromaticum) belonging to the genus Myrtaceae Syzygium of the family Myrtaceae, also known as clove.

Any part of clove can be used, such as flowers, flower buds, spikes, pericarp, fruits, stems, leaves, branches, foliage, trunks, bark, rhizomes, roots, seeds, whole plants, or combinations thereof, Flower buds are preferably used.

Examples of clove extracts include various solvent extracts obtained by extraction by known extraction methods, their diluted solutions, their concentrated solutions, and their dried powder. Known extraction methods include, for example, immersion, decoction, leaching, solid-liquid extraction, reflux extraction, supercritical extraction, ultrasonic extraction and microwave extraction. For example, the immersion includes immersion and leaching at 0 ° C. to the boiling point of the solvent (preferably 15 to 40 ° C.) for 1 hour to 4 weeks. ° C.) and 30 to 1000 rpm for 30 minutes to 2 weeks. In order to prevent the extract from being oxidized, a means of extracting in a so-called non-oxidizing atmosphere while removing dissolved oxygen by degassing by boiling or passing an inert gas such as nitrogen gas may be used in combination. Moreover, in the case of reflux extraction, it can be carried out using an extraction instrument such as a Soxhlet extractor.

Either a polar solvent or a non-polar solvent can be used as a solvent for extraction. Specific examples of the solvent include, for example, water; monohydric, dihydric or polyhydric alcohols; ketones such as acetone and methyl ethyl ketone; esters such as methyl acetate and ethyl acetate; Cyclic ethers; polyethers such as polyethylene glycol; saturated or unsaturated hydrocarbons such as hexane; aromatic hydrocarbons such as benzene and toluene; dimethylsulfoxide; acetonitrile; carbon dioxide, supercritical carbon dioxide; fats, waxes and other oils; and mixtures thereof. Preferred are water, alcohols and mixtures thereof from the viewpoint of pharmacological activity and versatility.
Examples of alcohols include methanol, ethanol, 1,3-butylene glycol, n-propanol, isopropanol, n-butanol, isobutanol, sec-butanol and t-butanol, with ethanol being more preferred.

For example, buds of clove Syzygium aromaticum Merrill et Perry (Eugenia caryophyllata Thunberg) (Myrtaceae) are dried, cut into small pieces, and immersed in a 50 vol% ethanol solution to obtain an extract. This extract is concentrated under reduced pressure, a 50 vol % ethanol solution is added to the concentrate, and then treated with activated charcoal to obtain a clove extract.

The clove extract of component (A) may be crudely purified, for example, as long as it conforms to the standards acceptable for cosmetics and pharmaceuticals and exhibits the effects of the present invention. In addition, if necessary, treatment such as removal of inert contaminants, deodorization, decoloration, etc. can be performed by known techniques such as liquid-liquid partition, solid-liquid partition, filtration membrane, activated carbon, adsorption resin, ion exchange resin, etc. Further, known separation and purification methods may be appropriately combined to increase their purity. Purification means include organic solvent precipitation, centrifugation, ultrafiltration membrane, high-performance liquid chromatograph, column chromatograph, and the like.

Moreover, as the component (A), for example, commercially available products such as Falcorex Choji (manufactured by Ichimaru Falcos Co., Ltd.) can be used.

The content of component (A) (in terms of solid content) is 0.002 to 0.035% by mass in the total composition from the viewpoint of imparting brightness and transparency to the skin, suppressing discoloration, and imparting stability over time. is preferred, and 0.003 to 0.02% by mass is more preferred.

In the Sambucus extract of component (B), "Sambucus nigra (also known as bone grafting tree)" refers to a plant belonging to the genus Sambucus of the Caprifoliaceae family: S. nigra L. .
Sambucus sambucus is used for its fruits, flowers, foliage, or a combination thereof. ) Blumeex Graebn.)”, Sieboldiana (Miq.) Blume ex Graebn. chinensis), and the fruits, flowers or foliage of S. williamsii Hanse.

Examples of Sambucus extract include various solvent extracts obtained by extraction in the same manner as component (A), their diluted solutions, their concentrated solutions, and their dried powder.
Moreover, as a component (B), commercial products, such as elder extract BG (made by Maruzen Pharmaceutical Co., Ltd.), can be used, for example.

The content of component (B) (in terms of solid content) is 0.00001 to 0.003% by mass in the entire composition from the viewpoint of imparting brightness to the skin, giving a sense of transparency, suppressing discoloration, and imparting stability over time. is preferred, and 0.00005 to 0.002% by mass is more preferred.

In the present invention, the total content of components (A) and (B) (in terms of solid content) is, in the entire composition, from the viewpoint of imparting brightness and transparency to the skin, suppressing discoloration, and imparting stability over time. 0.001 to 0.06% by mass is preferable, and 0.003 to 0.03% by mass is more preferable.

In the present invention, the mass ratio of component (B) to component (A) (in terms of solid content) (B)/(A) is 0.02 to 0.2 from the viewpoint of suppressing discoloration and imparting stability over time. preferably 0.03 to 0.1.

In the fucus extract of component (C), "fucus" refers to brown algae of the family Fucaceae and the genus Fucus.
As for fucus, the whole plant of fucus is usually used, but a specific part thereof may also be used.

The fucus extract includes various solvent extracts obtained by extraction in the same manner as for component (A), their diluted solutions, their concentrated solutions, and their dried powder.
Moreover, as the component (C), for example, commercially available products such as Falcorex Hibamata (manufactured by Ichimaru Falcos Co., Ltd.) can be used.

The content of component (C) (in terms of solid content) is 0.001 to 0.05% by mass in the total composition from the viewpoint of imparting brightness and transparency to the skin, suppressing discoloration, and imparting stability over time. is preferred, and 0.003 to 0.03% by mass is more preferred.

In the present invention, the mass ratio of component (C) to component (A) (in terms of solid content) (C)/(A) is 0.5 to 4 from the viewpoint of suppressing discoloration and imparting stability over time. is preferred, and 0.7 to 3 is more preferred.

In the present invention, the mass ratio of component (C) to the total amount of components (A) and (B) (in terms of solid content) (C) / ((A) + (B)) is discoloration suppression and stability over time From the point of imparting, it is 0.5 to 3, more preferably 0.8 to 2.5.

The skin cosmetic of the present invention preferably further contains a polyhydric alcohol from the viewpoint of imparting brightness and transparency to the skin and moisturizing effect.
As polyhydric alcohols, dihydric or trihydric polyhydric alcohols, which are commonly used in cosmetics, are preferred. Examples include ethylene glycol, diethylene glycol, polyethylene glycol (number average molecular weight less than 1000), propylene glycol, 3-propanediol, dipropylene glycol, polypropylene glycol (number average molecular weight less than 1000), 1,3-butylene glycol, glycerin, diglycerin, polyglycerin, isoprene glycol and the like.
Among these, it is more preferable to contain at least glycerin.

Polyhydric alcohols can be used singly or in combination of two or more, and the content is preferably 2 to 20% by mass, more preferably 5 to 15% by mass, based on the total composition.

In addition to the above ingredients, the skin cosmetic of the present invention may contain ingredients that are commonly used in cosmetics, such as surfactants, lower alcohols, fluorine compounds, resins, thickeners, anti-inflammatory agents, and so on, as long as they do not impair the effects of the present invention. Ingredients such as antibacterial agents, fragrances, moisturizing agents, salts, solvents, antioxidants, insect repellents, and physiologically active ingredients can be contained.

The skin cosmetic of the present invention can be suitably used for cosmetics, pharmaceuticals, quasi-drugs, and the like. Since the skin cosmetic of the present invention is excellent in moisturizing effect, it is preferably used as a type of skin cosmetic that is retained on the skin without being washed off. more preferred.

As the dosage form of the skin cosmetic of the present invention, liquid, milky lotion, cream, paste, solid, multi-layer, etc. can be applied, and furthermore, it can be applied as a sheet, a spray, and a mousse. can be done.

Examples 1-4, Comparative Examples 1-6
A skin cosmetic (skin lotion) having the composition shown in Table 1 was produced, and its stability, brightness and transparency were evaluated. The results are also shown in Table 1.

(Production method)
Citric acid, sodium citrate and purified water were heated at 80° C., and polyoxyethylene hydrogenated castor oil dissolved by heating at 80° C. was added while stirring with a propeller. After cooling with stirring, other ingredients were added and dispersed to produce a lotion.

(Evaluation method)
(1) Stability:
A 1000 ppm aqueous solution of iron (III) chloride hexahydrate was prepared and added to each cosmetic so as to have a final concentration of 5 ppm. Thirty minutes after the addition, the absorbance (300 nm to 800 nm) was measured with a spectrophotometer UV-2550 (manufactured by Shimadzu Corporation) at a pitch of 0.2 nm. The sum of the obtained absorbances at 300 nm to 800 nm was calculated and judged according to the following criteria.
⊚: Total value of absorbance is less than 400 (coloration is not observed).
◯: Total value of absorbance is 400 or more and less than 600 (almost no coloring is observed).
Δ: Total value of absorbance is 600 or more and less than 800 (slightly colored).
×: Total value of absorbance is 800 or more (noticeable coloring).
In addition, polyphenols contained in plant extracts may cause coloration over time due to the reaction with iron ions contained in trace amounts in the production process and containers, so iron ions are added to cosmetics. , evaluated the stability.

(2) Brightness:
Ten healthy women applied each cosmetic twice a day, morning and evening, for 4 weeks. As a result, the total score of 10 people was calculated and shown according to the following criteria.
(Evaluation criteria)
2 points; Brightened.
1 point; Slightly brightened.
0 point; no change.
(Judgment criteria; total score of 10 people)
A: 16 to 20 points.
O; 11 to 15 points.
△; 6 to 10 points.
×; 0 to 5 points.

(3) Transparency:
Ten healthy women applied each cosmetic twice a day, morning and evening, for 4 weeks. As a result, the total score of 10 people was calculated and shown according to the following criteria.
(Evaluation criteria)
2 points; Transparency was obtained.
1 point; Slightly transparent.
0 point; no change.
(Judgment criteria; total score of 10 people)
A; 16 to 20 points.
O; 11 to 15 points.
△; 6 to 10 points.
×; 0 to 5 points.

Formulation examples 1-3
A lotion having the composition shown in Table 2, an emulsion having the composition shown in Table 3, and a cream having the composition shown in Table 4 were each produced by a conventional method.
Each of the obtained cosmetics imparts transparency and brightness to the skin, is inhibited from discoloration over time, and has excellent stability.

Claims (4)

The following components (A), (B) and (C):
(A) clove extract 0.002 to 0.035% by mass (in terms of solid content) ,
(B) Sambucus nigra extract 0.00001 to 0.003% by mass (in terms of solid content) ,
(C) 0.001 to 0.05% by mass of fucus extract (in terms of solid content)
and the mass ratio of component (C) to the total amount of components (A) and (B) (in terms of solid content) (C) / ((A) + (B)) is 0.5 to 3 skin cosmetics. 2. The skin cosmetic composition according to claim 1 , wherein the mass ratio of component (C) to component (A) (in terms of solid content) (C)/(A) is 0.5-4. 3. The skin cosmetic according to claim 1, wherein the mass ratio (in terms of solid content) of component (B) to component (A) (B)/(A) is 0.02 to 0.2. The skin cosmetic composition according to any one of claims 1 to 3, wherein the total content of components (A) and (B) (in terms of solid content) is 0.001 to 0.06% by mass.