JP7229099B2 - blood purifier - Google Patents

Description

The present invention relates to a blood purification device.

In the blood purification apparatus, cleaning and disinfection processing for cleaning and disinfecting internal piping is performed after blood purification treatment. In the cleaning/disinfecting process, a cleaning/disinfecting chemical is introduced into the pipe to clean/disinfect the inside of the pipe (see, for example, Patent Document 1).

JP 2014-097197 A

Conventionally, during cleaning and disinfection, the flow rate of cleaning and disinfecting chemicals has been kept constant. However, the conventional method requires a large amount of chemical solution and needs improvement.

SUMMARY OF THE INVENTION Accordingly, an object of the present invention is to provide a blood purification apparatus capable of reducing the amount of cleaning and disinfecting chemicals used while maintaining sufficient cleaning and disinfecting effects.

In order to solve the above problems, the invention according to claim 1 is a blood purification apparatus for performing blood purification treatment via a blood purifier, comprising a pipe and a flow rate adjusting unit for adjusting the flow rate in the pipe. and a cleaning/disinfecting control unit that controls the flow rate adjusting unit to feed a cleaning/disinfecting chemical solution from a predetermined supply source into the pipe and perform cleaning/disinfection processing within the pipe, The cleaning/disinfecting control unit includes a chemical solution filling detection unit that detects that the pipe is filled with a cleaning/disinfecting chemical solution when the pipe is cleaned and disinfected, and the chemical solution filling detection unit detects that the pipe is filled with a chemical solution. a liquid medicine flow control unit that, when detecting that the liquid medicine is filled in the blood Provide a purification device.

In the invention according to claim 2, a sensor is provided in the pipe for detecting that a cleaning and disinfecting chemical solution is circulating in the pipe, and the chemical solution filling detection unit is based on the detection result of the sensor. 2. The blood purification apparatus according to claim 1, further comprising detecting filling of said chemical solution in said pipe.

In the invention according to claim 3, the sensor is configured to be capable of detecting the concentration of the chemical solution flowing through the pipe, and the chemical solution filling detection unit detects the concentration of the chemical solution detected by the sensor. 3. The blood purification apparatus according to claim 2, wherein the filling of the chemical solution in the pipe is detected when a preset delay time elapses after is equal to or greater than a predetermined reference value.

According to a fourth aspect of the present invention, the cleaning/disinfecting control unit determines that cleaning/disinfecting with the chemical solution is completed when a predetermined cleaning/disinfecting time has elapsed after detecting that the chemical solution was filled in the pipe. and before the cleaning and disinfection time elapses after detecting that the chemical solution is filled in the pipe, the chemical solution filling detection unit detects that the concentration of the chemical solution exceeds the reference value. 4. The blood according to claim 3, wherein the liquid medicine flow control unit increases the flow rate of the liquid medicine when detecting that it has fallen below, and the liquid medicine filling detection unit again detects whether the pipe is filled with the liquid medicine. Purifier.

According to the first aspect of the invention, it is possible to reduce the amount of cleaning and disinfecting chemicals used while maintaining a sufficient cleaning and disinfecting effect.

According to the second aspect of the invention, since the detection result of the sensor is used, it can be detected more accurately that the pipe is filled with the chemical solution.

According to the third aspect of the invention, it is possible to more accurately detect that the pipe is filled with the chemical solution.

According to the fourth aspect of the invention, even if the concentration of the chemical drops for some reason during cleaning and disinfection, it is possible to prevent the processing from ending with insufficient cleaning and disinfection.

1 is a schematic configuration diagram of a blood purification system using a blood purification device according to an embodiment of the present invention; FIG. 1 is a schematic configuration diagram of a blood purification device; FIG. (a) is a flow chart of cleaning/sterilization processing, and (b) is a flow chart in step S2 of (a).

[Embodiment]
BEST MODE FOR CARRYING OUT THE INVENTION An embodiment of the present invention will be described below with reference to the accompanying drawings.

FIG. 1 is a schematic configuration diagram of a blood purification system using a blood purification apparatus according to this embodiment. As shown in FIG. 1 , the blood purification system 10 includes a dialysate supply device 11 and a plurality of blood purification devices 1 .

The dialysate supply device 11 uses dialysis water supplied from a water treatment device (not shown) and a dialysate undiluted solution supplied from a dissolution device (not shown) to prepare a dialysate having a predetermined concentration, and supplies the prepared dialysate. It is supplied to each blood purification device 1 . The dialysate prepared by the dialysate supply device 11 is supplied to each blood purification device 1 through the dialysate supply line 12 .

The blood purification apparatus 1 is equipped with a blood purifier (dialyzer, not shown) for performing blood purification treatment (dialysis treatment) on a patient, and supplies dialysate supplied from a dialysate supply device 11 to each blood purifier. do. The details of the blood purification device 1 will be described later.

Blood purification system 10 is configured such that dialysate supply device 11 and each blood purification device 1 can communicate with each other via signal line 13 . The dialysate supply device 11 can detect the operation status of each blood purification device 1 and control each blood purification device 1 . The form of communication between the dialysate supply device 11 and each blood purification device 1 is not limited to this, and may be wireless communication instead of wired communication.

In the blood purification system 10, cleaning and disinfection processing for cleaning and disinfecting the inside of the pipe is performed after the blood purification treatment. Note that the cleaning and disinfection treatment referred to here includes the case of performing only cleaning, the case of performing only disinfection, and the case of performing both cleaning and disinfection. When cleaning and disinfecting treatment is performed, the dialysate supply device 11 prepares the chemical solution used for cleaning and disinfection, and the prepared chemical solution is supplied to each blood purification apparatus 1 through the dialysate supply line 12. be. In addition, the dialysate supply device 11 has a function of notifying each blood purification device 1 of the type of chemical solution to be used and the like during cleaning and disinfection processing. When the operator performs an operation to start the cleaning and disinfection process in the dialysate supply device 11, the dialysate supply device 11 and each blood purification device 1 are automatically operated according to a program preset in the dialysate supply device 11. A cleaning and disinfection process is performed.

(Blood purification device 1)
FIG. 2 is a schematic configuration diagram of the blood purification device 1. As shown in FIG. In addition, FIG. 2 schematically shows a piping configuration during cleaning and disinfection. As shown in FIG. 2, the blood purification apparatus 1 has a pair of connectors 2a and 2b to which a blood purifier (not shown) is connected. concatenated.

The piping 3 inside the blood purification apparatus 1 includes a supply-side channel 31 including a liquid supply port 3a to which the dialysate supply line 12 is connected and one connector 2a, the other connector 2b, and a liquid discharge port 3b. and a discharge side flow path 32 including.

The blood purification apparatus 1 also has a dual pump 5 configured so that the amount of liquid supplied to the blood purifier and the amount of liquid discharged from the blood purifier are mechanically equal. The dual pump 5 is one aspect of the flow rate adjusting section of the present invention. In this embodiment, the dual pump 5 is used to control the flow rate of liquid flowing through the pipe 3 . A water removal channel 33 is provided in the discharge side channel 32 so as to bypass the dual pump 5, and the water removal channel 33 is provided with a water removal pump 6 for controlling the amount of water removed from the blood. ing. Further, the supply-side channel 31 is provided with a liquid supply valve 7 which is an electromagnetic valve capable of shutting off the supply of liquid. Note that the configuration diagram of FIG. 2 is shown in a simplified manner, and even if a passage bypassing each part, an electromagnetic valve, a filter unit, a pressure sensor for measuring the liquid pressure, a temperature sensor for measuring the liquid temperature, etc. are provided as appropriate. good.

The blood purification apparatus 1 also includes a control device 8 that controls the dual pump 5, water removal pump 6, liquid supply valve 7, and the like. The control device 8 controls each part during blood purification treatment and during cleaning and disinfection.

In the blood purification apparatus 1 according to the present embodiment, a plurality of sensors 4 of different detection methods provided in the internal piping 3 and a plurality of sensors 4 are used to detect the cleaning and disinfecting liquids flowing through the piping 3. and a chemical identification unit 81 for identifying the type of chemical.

A plurality of sensors 4 are provided in the pipe 3 so as to be able to detect that a cleaning/disinfecting chemical solution is flowing through the pipe 3 . In this embodiment, the plurality of sensors 4 are used to determine the type of cleaning/disinfecting chemical solution. In this embodiment, as the plurality of sensors 4, a conductivity sensor 41 that measures the conductivity of the liquid flowing through the pipe 3, and an absorbance sensor that measures the absorbance of ultraviolet light in the 280 nm band by the liquid flowing through the pipe 3. 42 and were used. However, the sensor 4 is not limited to this, and may include a pH sensor or the like that measures the pH of the liquid flowing through the pipe 3, for example.

Conductivity sensor 41 is used to monitor the concentration of dialysate during blood purification treatment, and is provided in supply-side channel 31 . The absorbance sensor 42 measures the absorbance of the drainage from the blood purifier during blood purification treatment, detects the amount of urea nitrogen contained in the drainage, and is used to monitor the progress of dialysis. and is provided in the discharge side flow path 32 . In other words, in the present embodiment, the conductivity sensor 41 and the absorbance sensor 42, which have been conventionally used for blood purification treatment, are diverted to the purpose of discriminating the type of chemical solution for cleaning and disinfection. As a result, there is no need to separately provide a sensor for discriminating the type of cleaning and disinfecting chemical solution, which simplifies the system configuration and enables cost reduction.

Typical chemical solutions used for cleaning and disinfection include acid cleaning solutions, peracetic acid-based disinfectants, and sodium hypochlorite-based disinfectants. Of these, the acid washing solution and the hypochlorite disinfectant solution have different conductivities than the dialysis water, and therefore can be detected by the conductance sensor 41 . In addition, among the above chemical solutions, the peracetic acid-based disinfectant and hypochlorite-based disinfectant have different absorbances of ultraviolet light (ultraviolet light in the 280 nm band) compared to dialysis water, so they can be detected by the absorbance sensor 42. be. Thus, in this embodiment, two sensors 4 are used to detect two or more types (here, three types) of chemical solutions.

The conductivity detected by the conductivity sensor 41 and the absorbance detected by the absorbance sensor 42 depend on the concentration of the chemical liquid flowing through the pipe 3. Therefore, by detecting the conductivity and the absorbance, the concentration of the chemical liquid can be detected. Concentration can also be detected. In other words, in this embodiment, the sensor 4 is configured to be able to detect the concentration of the chemical liquid flowing through the pipe 3 .

The liquid medicine identifying section 81 is mounted on the control device 8, and is realized by appropriately combining an arithmetic element such as a CPU, a storage device such as a memory, software, an interface, and the like. Based on the detection results of a plurality of sensors 4 , the chemical liquid identification unit 81 is configured to be able to identify at least as many types of chemical liquids as the number of sensors 4 . In the present embodiment, the liquid medicine identifying section 81 is configured to be able to identify more types of liquid medicine than the number of the sensors 4 based on the combination of the detection results of the multiple sensors 4 .

More specifically, the chemical identification unit 81 sets a threshold value (reference value range) for the detection value of the conductivity sensor 41 and a threshold value (reference value range) for the detection value of the absorbance sensor 42 set for each type of chemical solution. ) with the detected values of the conductivity sensor 41 and the absorbance sensor 42 to identify the type of chemical solution. For example, when the detected values of the conductivity sensor 41 and the absorbance sensor 42 are within the reference value range for the acid cleaning liquid, the chemical liquid is identified as the acid cleaning liquid. Not limited to this, the medicinal solution identification unit 81 compares the measurement result of the dialysis water based on the detection results of the conductivity sensor 41 and the absorbance sensor 42, and when only the detection value of the conductivity sensor 41 changes If the amount of change is greater than or equal to a predetermined threshold value, the chemical is identified as an acid cleaning solution, and if only the detected value of the absorbance sensor 42 changes (when the amount of change is greater than or equal to a predetermined threshold value), identifies that the chemical is a peracetic acid-based disinfectant, and if the detected values of both the conductivity sensor 41 and the absorbance sensor 42 change (when the amount of change exceeds a predetermined threshold), the chemical is hypochlorite It may be identified as a system disinfectant.

In the present embodiment, the control unit 8 is configured to acquire information indicating the chemical solution used in the cleaning and disinfection process from the dialysate supply device 11 by communicating with the dialysate supply device 11 . The medicinal liquid identification unit 81 is configured to identify the medicinal liquid based on the acquired information indicating the medicinal liquid, and select a sensor corresponding to the identified medicinal liquid from among the plurality of sensors 4 .

Thus, in the present embodiment, the chemical identification unit 81 selects all or part of the plurality of sensors 4 according to the type of chemical to be used in cleaning and disinfection. In addition, the chemical liquid identification unit 81 is configured to identify whether the chemical liquid currently used is the chemical liquid that should be used in the cleaning and disinfection based on the detection results of all or some of the selected sensors 4. It is Since the above-described reference value range is set within a range that allows identification of the type of chemical solution, by determining whether the concentration of the chemical solution is within the predetermined reference value range, the concentration of the chemical solution and the type of the chemical solution can be determined. is appropriate. As a result, even if the user misunderstands the type of chemical solution to be supplied and a different type of chemical solution from the controlled chemical solution is sent from the dialysate supply device 11, the inappropriate type of chemical solution can be supplied. It is possible to avoid cleaning and disinfecting with a chemical solution.

The blood purification apparatus 1 also includes a cleaning/disinfecting control unit 82 that circulates cleaning/disinfecting chemicals in the internal pipe 3 to clean/disinfect the pipe 3 . The cleaning/disinfecting control unit 82 controls the double pump 5 as a flow rate adjusting unit to feed the chemical solution for cleaning/disinfecting from a predetermined supply source (here, the dialysate supply device 11) into the pipe 3, and Perform cleaning and disinfection treatment in 3. The cleaning/disinfecting control unit 82 executes cleaning/disinfecting processing according to instructions from the dialysate supply device 11 . The cleaning/disinfecting control unit 82 is mounted on the control device 8, and is realized by appropriately combining an arithmetic element such as a CPU, a storage device such as a memory, software, an interface, and the like. The cleaning/disinfecting control section 82 has a chemical filling detection section 821 and a chemical liquid flow rate control section 822 .

Based on the detection result of at least one sensor 4, the chemical filling detection unit 821 detects that the pipe 3 is filled with a chemical solution for cleaning and disinfection (from another liquid to the chemical solution) when the pipe 3 is cleaned and disinfected. replaced). The chemical filling detection unit 821 uses the detection result of the sensor 4 corresponding to the chemical identified by the chemical identifying unit 81, and compares the detection value of the sensor 4 with a threshold value corresponding to the identified chemical. At the position where 4 is provided, it is detected that the chemical has flowed into the pipe 3 . In other words, when the concentration of the chemical solution detected by the sensor 4 reaches or exceeds a predetermined reference value, the chemical solution filling detection unit 821 detects that the chemical solution has flowed through the pipe 3 at the position where the sensor 4 is provided. detect.

For example, when the chemical liquid used is identified as an acid cleaning liquid by the chemical liquid identifying section 81, the chemical liquid filling detection section 821 compares the detection value of the conductivity sensor 41 with a preset threshold value for the acid cleaning liquid. , it is detected that the chemical has flowed into the pipe 3 at the position where the conductivity sensor 41 is provided. As for the hypochlorite-based disinfectant, only one of the conductivity sensor 41 and the absorbance sensor 42 may be used to detect the flow of the chemical solution, or both sensors 41 and 42 may be used to detect the flow of the chemical solution. may

During cleaning and disinfection, all the pipes 3 need to be filled with the chemical solution to the downstream side of the sensor 4. Therefore, after detecting the circulation of the chemical solution, the chemical solution filling detection unit 821 detects the sensor 4 used for detecting the circulation of the chemical solution. When a delay time set in advance according to the pipe capacity of the pipe 3 downstream has passed, it is detected that the pipe 3 is filled with the chemical solution for cleaning and disinfection. For example, when the conductivity sensor 41 detects a chemical solution, the delay time is set longer because the conductivity sensor 41 is arranged upstream of the absorbance sensor 42 in the chemical solution feeding direction.

As described above, the threshold value (concentration reference value) and the length of the delay time for detecting the passage of the chemical solution differ depending on the chemical solution used. By providing the chemical liquid identification unit 81, even if there is a human error such as using a chemical liquid different from the intended one, it is possible to perform appropriate cleaning and disinfection processing according to the type of chemical liquid actually used. . If the medicinal solution notified from the dialysate supply device 11 is different from the identified medicinal solution, the medicinal solution identification unit 81 issues an alarm by, for example, transmitting an alert signal to the dialysate supply device 11. may be configured.

When the chemical filling detection unit 821 detects that the pipe 3 is filled with the chemical, the chemical liquid flow rate control unit 822 reduces the chemical liquid supply flow rate (hereinafter simply referred to as the chemical liquid flow rate) compared to before the detection. ) is reduced. In the present embodiment, the chemical liquid flow rate control section 822 is configured to control the flow rate of the chemical liquid by controlling the dual pump 5 .

According to the inventors' studies, the effect of cleaning and disinfection is dominant when the chemical solution is in contact with the pipe 3, and sufficient cleaning and disinfection effect can be obtained even if the flow rate of the chemical solution is reduced. was found. However, in order to perform cleaning and disinfection processing efficiently in a short time, it is desirable to increase the flow rate of the chemical solution as much as possible until the pipe 3 is filled with the chemical solution. Therefore, in the present embodiment, the flow rate of the chemical solution is reduced after the pipe 3 is filled with the chemical solution, and the amount of the chemical solution used is reduced while maintaining a sufficient cleaning and disinfecting effect.

In order to shorten the time required for the cleaning and disinfection process, it is desired that the flow rate of the chemical solution before the pipe 3 is filled with the chemical solution is as large as possible. Further, in order to reduce the amount of the chemical used, it is desired that the flow rate of the chemical after the pipe 3 is filled with the chemical is as small as possible. Therefore, the flow rate of the chemical solution after the pipe 3 is filled with the chemical solution is preferably 1/2 or less of the flow rate of the chemical solution before the pipe 3 is filled with the chemical solution, preferably 1/4 or less. is more desirable. However, if the flow rate of the chemical solution after the pipe 3 is filled with the chemical solution is reduced too much, dirt and the like will be less likely to be washed away, which may reduce the cleaning and disinfecting effect. Therefore, the flow rate of the chemical solution after the pipe 3 is filled with the chemical solution should be set to the extent that the effect of cleaning and disinfection can be maintained in consideration of the pipe capacity and the like.

The cleaning/disinfecting control unit 82 determines that cleaning/disinfecting with the chemical solution is completed when a predetermined cleaning/disinfecting time has elapsed since it was detected that the pipe 3 was filled with the chemical solution, and stops the duplex pump 5. It is configured to move to the next step (post-cleaning, etc., which will be described later). After the cleaning/disinfecting time has passed, the cleaning/disinfecting process may be finished with the double pump 5 stopped and the cleaning/disinfecting liquid enclosed in the pipe 3 . The cleaning/disinfecting time may be set for each chemical solution used. In order to sufficiently wash and disinfect electromagnetic valves such as the liquid supply valve 7, the washing/disinfecting control unit 82 waits until a predetermined washing/disinfecting time elapses after detecting that the pipe 3 is filled with the chemical solution. During this period, the solenoid valve may be controlled to open and close at predetermined time intervals.

In addition, if the concentration of the chemical drops for some reason (for example, if the chemical is insufficient) before the cleaning and disinfecting time elapses after detecting that the chemical is filled in the pipe 3, sufficient cleaning and disinfection will not be performed. It may not be effective. Therefore, after detecting that the pipe 3 is filled with the chemical solution and before the cleaning/disinfecting time elapses, the chemical solution filling detector 821 detects that the concentration of the chemical solution has fallen below the reference value (the value detected by the sensor 4 has fallen below the threshold value). is detected, the flow rate of the chemical solution is increased by the chemical solution flow rate control unit 822, and the cleaning/disinfection control unit 82 is operated so that the chemical solution filling detection unit 821 again detects whether the pipe 3 is filled with the chemical solution. may be configured. As a result, even if the concentration of the chemical drops for some reason during cleaning and disinfection, it is possible to prevent the processing from ending with insufficient cleaning and disinfection. Further, the cleaning/disinfecting control section 82 may be configured to issue an alarm by, for example, transmitting an alert signal to the dialysate supply device 11 when detecting a decrease in the concentration of the chemical solution.

Here, the procedure of the cleaning and disinfecting process will be described with reference to FIGS. 3(a) and 3(b). When the cleaning and disinfection process is started, the dialysate for blood purification treatment remains in the pipe 3 . Therefore, as shown in FIG. 3(a), in the cleaning and disinfecting process, first, in step S1, pre-cleaning is performed to replace the dialysate in the pipe 3 with dialysis water. Thereafter, in step S2, cleaning and disinfection using a chemical solution for cleaning and disinfection is performed. Thereafter, in step S3, post-cleaning is performed to replace the chemical solution in the pipe 3 with dialysis water. As described above, the cleaning/disinfecting process may be terminated while the chemical solution is enclosed in the pipe 3 without performing cleaning after step S3. In this case, post-washing is performed before performing the next blood purification treatment.

As mentioned above, the conductivity sensor 41 used as sensor 4 can detect the concentration of dialysate and the absorbance sensor 42 can detect the concentration of urea nitrogen in the effluent. Therefore, by monitoring the detected values of the conductivity sensor 41 and the absorbance sensor 42, it is possible to detect whether the dialysate (including the waste liquid) in the pipe 3 has been replaced with the dialysis water during pre-washing. . Therefore, in the present embodiment, the cleaning/disinfecting control unit 82 can detect whether the dialysate in the pipe 3 has been replaced with dialysis water based on the detection result of at least one sensor 4 during the pre-cleaning in step S1. is configured to The cleaning/disinfecting control unit 82 determines whether the inside of the pipe 3 has been replaced with dialysis water based on the detection result of the sensor 4. When it is determined that the inside of the pipe 3 has been replaced with dialysis water, the cleaning in step S2 is performed. Configured to transition to disinfection. If the chemical solution is introduced while the dialysate remains in the pipe 3, the intended cleaning and disinfecting effect may not be obtained, but according to the present embodiment, such problems can be suppressed.

In addition, since the sensor 4 can detect the concentration of the cleaning and disinfecting chemical solution, by monitoring the detection value of the sensor 4, it is possible to detect whether the chemical solution in the pipe 3 has been replaced with dialysis water during post-cleaning. is. Therefore, in the present embodiment, the cleaning/disinfecting control unit 82 can detect whether the chemical solution in the pipe 3 has been replaced with dialysis water based on the detection result of at least one sensor 4 during post-cleaning in step S3. It is configured. The cleaning/disinfecting control unit 82 determines whether the inside of the pipe 3 has been replaced with dialysis water based on the detection result of the sensor 4, and when it is determined that the inside of the pipe 3 has been replaced with dialysis water, the cleaning/disinfection process is performed. configured to terminate. If the treatment is terminated while the chemical solution remains in the pipe 3, the chemical solution will come into contact with the patient's blood during the next treatment, which may adversely affect the blood purification treatment. Such problems can be suppressed.

As shown in FIG. 3B, in the cleaning and disinfection of step S2, first, in step S20, the control unit 8 communicates with the dialysate supply device 11 to perform cleaning and disinfection processing from the dialysate supply device 11. Acquire information indicating the chemical solution used in the Subsequently, the chemical liquid identification unit 81 identifies the chemical liquid based on the information indicating the chemical liquid, and selects a sensor corresponding to the identified chemical liquid from among the plurality of sensors 4 .

After that, in step S21, the chemical identification unit 81 uses the sensor 4 selected in step S20 to determine whether the concentration of the chemical is within a predetermined reference value range. In addition, the chemical identification unit 81 identifies the type of chemical through the determination in step S21. That is, since the reference value range is set within a range that allows identification of the type of the chemical solution, by determining whether the concentration of the chemical solution is within the predetermined reference value range, the concentration of the chemical solution and the type of the chemical solution can be determined. is appropriate or not. Furthermore, in step S20, information indicating the type of the chemical solution is acquired and the type of the chemical solution is specified, but the user may mistake the type of the chemical solution to be supplied, and the type of the chemical solution to be supplied may be different from the controlled chemical solution. is fed from the dialysate supply device 11, the type of the chemical is identified in step S21, so cleaning and disinfection with an inappropriate type of chemical can be avoided. .

If NO is determined in step S21, the process returns to step S21 and the determination is repeated. If the determination in step S21 is YES, then in step S22, the chemical solution filling detector 821 detects whether the pipe 3 is filled with the chemical solution. Specifically, the chemical solution filling detection unit 821 detects that the pipe 3 is filled with the chemical solution when a predetermined delay time elapses after the determination in step S21 is YES. If NO in step S22, the process returns to step S21.

If YES is determined in step S22, the chemical liquid flow rate control unit 822 controls the dual pump 5 to reduce the chemical liquid flow rate in step S23. After that, in step S24, based on the detection result of the sensor 4, it is determined whether the concentration of the chemical solution is within the reference value range. If the determination in step S24 is NO, in step S25 the chemical liquid flow control unit 822 controls the dual pump 5 to increase the flow rate of the chemical liquid, and then returns to step S21. Note that if the concentration of the chemical solution is monitored by an external device and there is no danger of the concentration of the chemical solution decreasing, steps S24 and S25 can be omitted.

If the determination in step S24 is YES, in step S26 the cleaning/disinfecting control unit 82 determines whether a preset cleaning/disinfecting time has elapsed since it was determined in step S22 that the pipe 3 was filled with the chemical solution. judge. If NO in step S26, the process returns to step S24.

If the determination in step S26 is YES, in step S27, the cleaning/disinfecting control section 82 stops the dual pump 5 to stop the flow of the chemical solution. After that, the process returns (proceeds to step S3 in FIG. 3(a)).

(Modification)
In the present embodiment, a case has been described in which information indicating the chemical solution to be used is acquired in advance from the dialysate supply device 11, but this process (the process of step S20 described above) is omitted, and the chemical solution is identified by the plurality of sensors 4. You may make it In this case, instead of selecting a sensor to be used from among the plurality of sensors 4 and identifying the chemical solution based on the detection results of only this sensor, all of the plurality of sensors 4 are used and the chemical solution is identified based on the detection results of the plurality of sensors 4. should be identified.

In the present embodiment, the blood purification apparatus 1 to which the dialysate and the cleaning and disinfecting chemicals are supplied from the external dialysate supply device 11 has been described. It may be provided with an adjusting mechanism. The blood purification apparatus 1 may have a built-in tank or the like for supplying cleaning and disinfecting chemicals, or the cleaning and disinfecting chemicals may be supplied from a separate tank or the like. may

In addition, although the explanation is omitted in FIG. 3( a ), cleaning using different chemical solutions, such as cleaning and sterilizing using an acid cleaning solution, followed by cleaning and sterilizing using a hypochlorite disinfectant. - Naturally, it is also possible to perform sterilization continuously. In this case, after cleaning and sterilization using an arbitrary chemical solution is completed, a cleaning step is performed to replace the inside of the pipe 3 with dialysis water, and then cleaning and sterilization using other chemical solutions are performed, so that the chemical solutions are not mixed. It is desirable to avoid This is because if different chemical solutions are mixed, toxic substances such as chlorine gas may be generated depending on the combination of chemical solutions. In such a case, the cleaning/disinfecting control unit 82 determines whether the inside of the pipe 3 has been replaced with dialysis water based on the detection result of the sensor 4 during the cleaning step, and determines that the inside of the pipe 3 has been replaced with dialysis water. It is preferable to be configured to shift to cleaning and disinfection using the next chemical solution when the cleaning is completed. This makes it possible to further suppress the mixing of the chemical solutions.

Furthermore, in the present embodiment, it is detected that the chemical solution is filled in the pipe 3 based on the detection result of the sensor 4. However, the present invention is not limited to this. It can also be determined that the chemical solution has been filled. However, in this case, since the chemical liquid is not physically detected, it can be said that the certainty is slightly inferior. That is, as in the present embodiment, by determining whether the pipe 3 is filled with the chemical solution based on the detection result of the sensor 4, the filling of the pipe 3 with the chemical solution can be detected more accurately. Is possible.

(Actions and effects of the embodiment)
As described above, in the blood purification apparatus 1 according to the present embodiment, the cleaning/disinfecting control unit 82 can detect that the pipe 3 is filled with a chemical solution for cleaning/disinfecting when the pipe 3 is cleaned/disinfected. A chemical solution filling detection unit 821, and a chemical solution flow rate control unit 822 that, when the chemical solution filling detection unit 821 detects that the pipe 3 is filled with the chemical solution, reduces the chemical solution delivery flow rate compared to before the detection. and have.

As a result, after the pipe 3 is filled with the chemical solution, the flow rate of the chemical solution is reduced, and the amount of the chemical solution used for cleaning and disinfection can be reduced while maintaining a sufficient cleaning and disinfecting effect. , the running cost of the blood purification apparatus 1 can be suppressed.

(Summary of embodiment)
Next, technical ideas understood from the embodiments described above will be described with reference to the reference numerals and the like in the embodiments. However, each reference numeral and the like in the following description do not limit the constituent elements in the claims to the members and the like specifically shown in the embodiment.

[1] A blood purification device (1) for performing blood purification treatment via a blood purifier, comprising: a pipe (3); A cleaning/disinfecting control unit that controls a flow rate adjusting unit (5) to feed a chemical solution for cleaning/disinfecting from a predetermined supply source into the pipe (3), thereby cleaning/disinfecting the inside of the pipe (3). (82), wherein the cleaning/disinfecting control unit (82) detects that the pipe (3) is filled with a chemical solution for cleaning/disinfecting when the pipe (3) is cleaned and disinfected. When the chemical solution filling detection unit (821) detects that the chemical solution is filled in the pipe (3), the amount of the chemical solution is compared with that before the detection. A blood purification device (1) comprising a chemical solution flow rate control section (822) that reduces the flow rate of liquid delivery.

[2] A sensor (4) is provided in the pipe (3) and detects that a cleaning and disinfecting chemical solution is circulating in the pipe (3), and the chemical solution filling detection unit (821) The blood purification device (1) according to [1], wherein filling of the chemical solution in the pipe (3) is detected based on the detection result of the sensor (4).

[3] The sensor (4) is configured to be capable of detecting the concentration of the chemical liquid flowing through the pipe (3), and the chemical liquid filling detection section (821) detects the [2] detecting that the pipe (3) is filled with the chemical when a preset delay time elapses after the detected concentration of the chemical becomes equal to or higher than a predetermined reference value; Blood purification device (1) as described.

[4] The cleaning/disinfecting control unit (82) completes cleaning/disinfecting with the chemical when a predetermined cleaning/disinfecting time has elapsed after detecting that the pipe (3) was filled with the chemical. and before the cleaning and disinfection time elapses after detecting that the pipe (3) is filled with the chemical, the chemical filling detection unit (821) detects the chemical When it is detected that the concentration of is below the reference value, the chemical liquid flow rate control unit (822) increases the flow rate of the chemical liquid, and the chemical liquid filling detection unit (821) again causes the liquid chemical to enter the pipe (3). The blood purification device (1) according to [3], which detects that the drug solution has been filled.

Although the embodiments of the present invention have been described above, the embodiments described above do not limit the invention according to the scope of claims. Also, it should be noted that not all combinations of features described in the embodiments are essential to the means for solving the problems of the invention.

Moreover, the present invention can be modified appropriately without departing from the gist thereof. For example, in the above-described embodiment, the case where the liquid medicine identifying section 81 is provided has been described, but the liquid medicine identifying section 81 can be omitted.

DESCRIPTION OF SYMBOLS 1... Blood purification apparatus 3... Piping 4... Sensor 41... Conductivity sensor 42... Absorbance sensor 5... Duplex pump (flow control unit)
8... Control device 81... Chemical identification unit 82... Cleaning and disinfection control unit 821... Chemical filling detection unit 822... Chemical solution flow rate control unit

Claims (4)

A blood purification device for performing blood purification treatment via a blood purifier,
piping;
a flow rate adjusting unit that adjusts the flow rate in the pipe;
a cleaning/disinfecting control unit that controls the flow rate adjusting unit to send a cleaning/disinfecting chemical solution from a predetermined supply source into the pipe to perform cleaning/disinfection processing in the pipe;
The cleaning and disinfecting control unit
a chemical solution filling detection unit that detects that the pipe is filled with a chemical solution for cleaning and disinfection when the pipe is cleaned and disinfected;
When the chemical solution filling detection unit detects that the chemical solution is filled in the pipe, the chemical solution is sent into the pipe by reducing the liquid supply flow rate of the chemical solution compared to before the detection. A chemical liquid flow rate control unit,
Blood purifier. a sensor provided in the pipe for detecting that a chemical solution for cleaning and disinfection is circulating in the pipe;
The chemical filling detection unit detects that the chemical is filled in the pipe based on the detection result of the sensor.
The blood purification device according to claim 1. The sensor is configured to be able to detect the concentration of the chemical liquid circulating in the pipe,
The chemical solution filling detection unit detects that the chemical solution is filled in the pipe when a preset delay time elapses after the concentration of the chemical solution detected by the sensor reaches or exceeds a predetermined reference value. To detect,
The blood purification device according to claim 2. The cleaning and disinfecting control unit
configured to determine that cleaning and disinfection with the chemical solution is completed when a predetermined cleaning and disinfecting time has elapsed after detecting that the pipe was filled with the chemical solution,
and when the chemical filling detection unit detects that the concentration of the chemical has fallen below the reference value before the cleaning and disinfection time has elapsed after detecting that the chemical was filled in the pipe. , the chemical liquid flow control unit increases the flow rate of the chemical liquid, and the chemical liquid filling detection unit again detects that the chemical liquid is filled in the pipe;
The blood purification device according to claim 3.

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