JP7239222B2 - alcohol composition - Google Patents

Description

The present invention relates to alcohol compositions.

Alcohol antiseptic compositions containing lower alcohols such as ethanol are mainly used at medical sites and the like for the purpose of disinfecting hands and fingers. Examples of common usage modes include a mode of spraying a liquid agent from a spray container; a mode of discharging a gel agent from a pump container; a mode of discharging a liquid agent in foam form using a pump container; be done.

Of these modes of use, the mode of spraying the liquid agent from a spray container tends to drip when sprayed onto the fingers, easily staining the floor, etc., and may scatter and get in the eyes or mouth. In addition, when the gel is discharged from the pump container, the gel may solidify and clog the nozzle, or the gel may partially solidify at the tip of the nozzle, causing the discharge direction to deviate from the predetermined direction. be. On the other hand, when the liquid agent is discharged from the pump container in the form of foam, it is difficult for the liquid to drip when discharged onto the fingers, and the foamed disinfectant can be retained for a long time on the fingers. Excellent in sex.

Here, since lower alcohols such as ethanol have an antifoaming effect, it is generally difficult to foam the alcohol disinfectant composition and to stably maintain the formed foam. In view of such problems, various alcohol disinfectant compositions have been proposed so far.

For example, Patent Literature 1 discloses a foam-type high-concentration alcohol preparation containing alcohol at a high concentration. Patent Literature 1 describes blending a fluorine-based anionic surfactant and a cationic compound in order to make a liquid agent foamy and maintain the formed foam stably.

Further, Patent Literature 2 discloses a foamable alcohol composition that contains alcohol at a high concentration and foams when mixed with air at a low pressure. Patent Literature 2 describes that a specific silicone-based surfactant is blended in order to foam the liquid agent.

JP 2012-219094 A Japanese Patent No. 5687733

An object of the present invention is to provide a novel alcohol composition that has foamability and excellent foam stability.

Specific means for solving the above problems include the following embodiments.
<1> Contains a lower alcohol having 1 to 4 carbon atoms, water, an aliphatic higher alcohol having 12 to 20 carbon atoms, and a surfactant other than the aliphatic higher alcohol, and the content of the lower alcohol is 20% by volume or more, the surfactant is at least one selected from anionic surfactants, cationic surfactants, and amphoteric surfactants, and the aliphatic higher alcohol and the interface An alcoholic composition having a molar ratio of 1:3 to 3:1 with the active agent .
<2> The alcohol composition according to <1>, wherein the lower alcohol is ethanol.
<3> The alcohol composition according to <1> or <2>, wherein the fatty higher alcohol is a linear saturated fatty alcohol .

ADVANTAGE OF THE INVENTION According to this invention, the novel alcohol composition which has foamability and is excellent in foam stability can be provided.

1 is a diagram showing foam stability of an alcohol composition prepared in Test Example 1. FIG. 2 is a diagram showing foam stability of the alcohol composition prepared in Test Example 2. FIG. 2 is a diagram showing foam stability of an alcohol composition prepared in Test Example 3. FIG. 2 is a diagram showing foam stability of an alcohol composition prepared in Test Example 4. FIG. FIG. 5 is a diagram showing foam stability of the alcohol composition prepared in Test Example 5. FIG. 2 is a diagram showing the static surface tension of an alcohol composition prepared in Test Example 6. FIG. FIG. 10 is a diagram showing the dynamic surface tension of the alcohol composition prepared in Test Example 6; FIG. 10 is a diagram showing the foam stability of the alcohol composition prepared in Test Example 7; FIG. 10 is a diagram showing foam stability of the alcohol composition prepared in Test Example 8. FIG. FIG. 10 is a diagram showing the dynamic friction coefficient of the alcohol composition prepared in Test Example 9; Fig. 10 shows the foamability and foam stability when the alcohol composition prepared in Test Example 10 was stored at -10°C for 3 days and then stored in a constant temperature bath at 25°C for 3 to 24 hours. FIG. 10 is a diagram showing foam stability of the alcohol composition prepared in Test Example 11. FIG.

The alcohol composition according to the present embodiment contains a lower alcohol having 1 to 4 carbon atoms, water, an aliphatic higher alcohol having 12 to 20 carbon atoms, and a surfactant other than the above aliphatic higher alcohol, The lower alcohol content is 20% by volume or more. This alcohol composition has foamability and excellent foam stability, and can stably maintain the formed foam. The reason why the alcohol composition according to the present embodiment is excellent in foam stability is not necessarily clear, but by arranging surfactant molecules and aliphatic higher alcohol molecules on the gas-liquid interface film of the foam, the gas-liquid interface It is presumed that this is because the strength of the film is improved.

(lower alcohol having 1 to 4 carbon atoms)
The alcohol composition according to this embodiment contains a lower alcohol having 1 to 4 carbon atoms. Specific examples of lower alcohols having 1 to 4 carbon atoms include methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, sec-butanol and tert-butanol. Among these, ethanol, n-propanol and isopropanol are preferred, and ethanol is more preferred.

The content of the lower alcohol (25 ° C.) is 20% by volume or more, preferably 20 to 90% by volume, more preferably 20 to 80% by volume, relative to the total amount of the alcohol composition, More preferably 30 to 70% by volume, particularly preferably 40 to 70% by volume.

(water)
The alcohol composition according to this embodiment contains water. The water content is, for example, preferably 5 to 84% by mass, more preferably 10 to 80% by mass, and further preferably 20 to 70% by mass, relative to the total amount of the alcohol composition. It is preferably 30 to 60% by mass, and particularly preferably 30 to 60% by mass.

(Aliphatic higher alcohol having 12 to 20 carbon atoms)
The alcohol composition according to this embodiment contains an aliphatic higher alcohol having 12 to 20 carbon atoms. The fatty higher alcohols may be linear or branched, saturated or unsaturated.

Specific examples of the aliphatic higher alcohols include 1-dodecanol, 1-tridecanol, 1-tetradecanol, 1-pentadecanol, 1-hexadecanol, paremitoyl alcohol, 1-heptadecanol, 1- octadecanol (stearyl alcohol), isostearyl alcohol, oleyl alcohol, 1-nonadecanol, 1-eicosanol and the like. Among these, linear saturated aliphatic alcohols are preferable from the viewpoint of enhancing the foam stability of the alcohol composition. In addition, from the viewpoint of increasing the solubility in water and increasing the foam stability of the alcohol composition, the aliphatic higher alcohol preferably has 12 to 18 carbon atoms, and preferably has 12 to 16 carbon atoms. is more preferred, and it is even more preferred that it has 14 to 16 carbon atoms.

The content of the aliphatic higher alcohol is, for example, preferably 0.01 to 10% by mass, more preferably 0.1 to 7% by mass, and 0.01 to 10% by mass, based on the total amount of the alcohol composition. More preferably 1 to 5% by mass, particularly preferably 0.1 to 3% by mass.

(Surfactant)
The alcohol composition according to this embodiment contains a surfactant other than the higher aliphatic alcohol. The surfactant is not particularly limited as long as it has foaming properties (foaming surfactant), anionic surfactants, cationic surfactants, amphoteric surfactants, nonionic surfactants. , fluorine-based surfactants, silicone-based surfactants, and the like. Among these, at least one selected from anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants from the viewpoint of reducing the stickiness of the alcohol composition and enhancing the feeling of use. Species are preferred, and at least one selected from anionic surfactants, cationic surfactants and amphoteric surfactants is more preferred.

Anionic surfactants are surfactants having anionic groups such as a carboxy group, a sulfonic acid group, a sulfate group, and a phosphate group, and include higher fatty acids, N-acylamino acids, N-acyl-N-methyltaurine, Alkyl ether carboxylic acids, alkyl phosphoric acids, polyoxyethylene alkyl ether phosphoric acids, alkyl sulfuric acids, polyoxyethylene alkyl ether sulfuric acids, sulfonic acid compounds having an alkyl group, salts thereof, and the like.
R ¹ in higher fatty acids (R ¹ -COOH) and R ² in the acyl moieties (R ² -C(=O)-) of N-acylamino acids and N-acylmethyl taurine are linear or branched A saturated or unsaturated hydrocarbon group is preferable, and a linear or branched alkyl group is more preferable. R ¹ and R ² preferably have 6 to 30 carbon atoms, more preferably 7 to 26 carbon atoms, and even more preferably 8 to 22 carbon atoms.
The alkyl group in the alkyl ether carboxylic acid, alkyl phosphoric acid, polyoxyethylene alkyl ether phosphoric acid, alkyl sulfuric acid, polyoxyethylene alkyl ether sulfuric acid, and sulfonic acid compound having an alkyl group may be linear or branched. may be The alkyl group preferably has 6 to 30 carbon atoms, more preferably 7 to 26 carbon atoms, and even more preferably 8 to 22 carbon atoms.
Salts include sodium salts, potassium salts, triethanolamine salts, ammonium salts and the like.

Cationic surfactants are surfactants having cationic groups such as ammonium groups and primary to tertiary amino groups, and examples include quaternary ammonium salts. R ³ , R ⁴ , R 5 ^and R ⁶ in quaternary ammonium ([NR ³ R ⁴ R ⁵ R ⁶ ] ⁺ ) are preferably alkyl groups or hydroxyalkyl groups. R ³ preferably has 6 to 30 carbon atoms, more preferably 7 to 26 carbon atoms, and even more preferably 8 to 22 carbon atoms. Also, R ⁴ , R ⁵ and R ⁶ preferably have 1 to 3 carbon atoms.
Salts include halides such as bromides and chlorides.

Amphoteric surfactants are surfactants having an anionic group and a cationic group, and include amidobetaine amphoteric surfactants, betaine acetate amphoteric surfactants, sulfobetaine amphoteric surfactants, and imidazoline amphoteric surfactants. agents and the like. These amphoteric surfactants have linear or branched alkyl groups. The alkyl group preferably has 6 to 30 carbon atoms, more preferably 7 to 26 carbon atoms, and even more preferably 8 to 22 carbon atoms. Amidobetaine-type amphoteric surfactants are betaines with an amide moiety (R ⁷ -C(=O)-NH-). ^R7 represents a linear or branched alkyl group. Betaine acetate-type amphoteric surfactants are betaines having an acetate moiety and a linear or branched alkyl. Sulfobetaine-type amphoteric surfactants are betaines having a sulfonic acid moiety and a linear or branched alkyl group. Imidazoline-type amphoteric surfactants are betaines having an imidazolinium moiety and a linear or branched alkyl group.

Nonionic surfactants are surfactants that do not have an anionic group and a cationic group, and include alkylpolyglucosides in which sugars and higher aliphatic alcohols are glycoside-bonded. The aliphatic higher alcohol preferably has 6 to 30 carbon atoms, more preferably 7 to 26 carbon atoms, and even more preferably 8 to 22 carbon atoms.

Among these surfactants, N-acylamino acids, N-acyl-N-methyltaurine, and salts thereof are particularly preferred.
N-acyl amino acids include N-acylglutamic acids such as N-lauroylglutamic acid, N-myristoylglutamic acid, N-stearoylglutamic acid, N-cocoylglutamic acid; N-lauroylaspartic acid, N-myristoylaspartic acid, N-stearoylaspartic acid , N-cocoylaspartic acid; N-acylaspartic acids such as N-lauroylalanine, N-myristoylalanine, N-cocoylalanine; N-lauroyl-N-methylalanine, N-myristoyl-N- N-acyl-N-methylalanine such as methylalanine and N-cocoyl-N-methylalanine; N-acylglycine such as N-cocoylglycine; N such as N-lauroylsarcosine, N-myristoylsarcosine and N-cocoylsarcosine - acyl sarcosine;
N-acyl-N-methyl taurine includes N-lauroyl-N-methyl taurine, N-myristoyl-N-methyl taurine, N-palmitoyl-N-methyl taurine, N-stearoyl-N-methyl taurine, N-cocoyl -N-methyl taurine and the like.

The content of the surfactant is, for example, preferably 0.01 to 10% by mass, more preferably 0.1 to 7% by mass, relative to the total amount of the alcohol composition, and 0.1 It is more preferably 5% by mass, particularly preferably 0.1 to 3% by mass.

Further, the molar ratio of the aliphatic higher alcohol and the surfactant is preferably 1:3 to 3:1, more preferably 1:2 to 3:1, and 1:2 to 2. :1 is more preferable.

(other ingredients)
The alcohol composition according to the present embodiment may further contain components other than those described above. Other ingredients include moisturizers, preservatives, antibacterial agents, thickeners, oils, solvents, perfumes, pH adjusters and the like.

(Method for preparing alcohol composition)
The method for preparing the alcohol composition according to this embodiment is not particularly limited. An example of the preparation method includes a method of mixing and stirring the lower alcohol, the higher aliphatic alcohol, the surfactant, and water. Another example of the preparation method includes a method of mixing and stirring the higher aliphatic alcohol, the surfactant, and water, and then adding the aqueous solution of the lower alcohol and further stirring.

(Mode of use of alcohol composition)
The alcohol composition according to the present embodiment is used as an alcohol disinfectant composition, for example, by filling a pump container (pump foamer) capable of foaming and discharging a liquid agent. According to the alcohol composition according to the present embodiment, since foam with excellent foam stability is formed, the foam disinfectant can be retained over the entire fingers for a long time, resulting in excellent usability.

EXAMPLES The present invention will be described in more detail with reference to examples below, but the present invention is not limited to these examples.

<Test Example 1>
Sodium dodecyl sulfate (SDS) was prepared as the surfactant. Also, 1-dodecanol (C ₁₂ OH), 1-tetradecanol (C ₁₄ OH), and 1-hexadecanol (C ₁₆ OH) were prepared as the aliphatic higher alcohols. Ethanol, water, surfactant and aliphatic higher alcohol are mixed in a beaker, the ethanol concentration is 20% by volume, the molar ratio of SDS and aliphatic higher alcohol is 1:3, the total of SDS and aliphatic higher alcohol An alcohol composition (25° C.) having a concentration of 0.1% by mass was prepared. Also, for comparison, an alcohol composition was prepared without blending an aliphatic higher alcohol.

The resulting alcoholic composition was vigorously shaken and then allowed to stand for 24 hours. Fig. 1 shows the state of the foam immediately after shaking, after 1 hour, and after 24 hours. As shown in FIG. 1, when 1-dodecanol, 1-tetradecanol, or 1-hexadecanol was blended with SDS, a large amount of foam remained even after 24 hours from shaking, and foam stability was improved. was extremely good.

<Test Example 2>
An alcohol composition (25° C.) was prepared in the same manner as in Test Example 1, except that the ethanol concentration was changed to 40% by volume and the total concentration of SDS and aliphatic higher alcohol was changed to 1% by mass. Also, for comparison, an alcohol composition was prepared without blending an aliphatic higher alcohol.

The resulting alcoholic composition was vigorously shaken and then allowed to stand for 24 hours. Fig. 2 shows the state of the foam immediately after shaking, after 1 hour, and after 24 hours. As shown in FIG. 2, when 1-dodecanol was blended with SDS, foam remained even after 1 hour from shaking, and the foam stability was excellent compared to when no aliphatic higher alcohol was blended. . Further, when 1-tetradecanol or 1-hexadecanol was blended with SDS, a large amount of foam remained even after 24 hours from shaking, indicating extremely excellent foam stability.

<Test Example 3>
An alcohol composition (25° C.) was prepared in the same manner as in Test Example 2, except that the molar ratio of SDS and higher aliphatic alcohol was changed to 1:1. Also, for comparison, an alcohol composition was prepared without blending an aliphatic higher alcohol.

The resulting alcoholic composition was vigorously shaken and then allowed to stand for 24 hours. Fig. 3 shows the state of the foam immediately after shaking, after 1 hour, and after 24 hours. As shown in FIG. 3, when 1-dodecanol was blended with SDS, foam remained even after 1 hour from shaking, and the foam stability was excellent compared to when no aliphatic higher alcohol was blended. . Further, when 1-tetradecanol or 1-hexadecanol was blended with SDS, a large amount of foam remained even after 24 hours from shaking, indicating extremely excellent foam stability.

<Test Example 4>
An alcohol composition (25° C.) was prepared in the same manner as in Test Example 2, except that the molar ratio of SDS and higher aliphatic alcohol was changed to 3:1. Also, for comparison, an alcohol composition was prepared without blending an aliphatic higher alcohol.

The resulting alcoholic composition was vigorously shaken and then allowed to stand for 24 hours. Fig. 4 shows the state of the foam immediately after shaking, after 1 hour, and after 24 hours. As shown in FIG. 4, when 1-dodecanol, 1-tetradecanol, or 1-hexadecanol was blended with SDS, bubbles remained even after 1 hour from shaking, and the aliphatic higher alcohol was used. It was superior in foam stability compared to the case where it was not blended.

<Test Example 5>
The ethanol concentration was changed to 60% by volume, and 1-tetradecanol (C ₁₄ OH), 1-hexadecanol (C ₁₆ OH), and 1-octadecanol (C ₁₈ OH) were used as the aliphatic higher alcohols. An alcohol composition (25° C.) was prepared in the same manner as in Test Example 3. Also, for comparison, an alcohol composition was prepared without blending an aliphatic higher alcohol.

The resulting alcoholic composition was vigorously shaken and then allowed to stand still for 30 seconds. Fig. 5 shows the state of the foam immediately after shaking, 10 seconds later, and 30 seconds later. As shown in FIG. 5, when 1-tetradecanol, 1-hexadecanol, or 1-octadecanol was blended with SDS, bubbles remained even after 30 seconds from shaking, and the aliphatic high-grade The foam stability was excellent compared to the case where no alcohol was blended.

<Test Example 6>
An alcohol composition (25° C.) was prepared in the same manner as in Test Example 2 using 1-dodecanol (C ₁₂ OH) as the aliphatic higher alcohol. The static and dynamic surface tensions of the resulting alcohol compositions are shown in Figures 6A and 6B. As shown in FIGS. 6A and 6B, the addition of 1-dodecanol significantly reduced the surface tension, suggesting that the 1-dodecanol molecules were arranged in the air-liquid interfacial film of the foam.

<Test Example 7>
The surfactant was changed to cetyltrimethylammonium bromide (CTAB), sodium N-lauroyl glutamate (C ₁₂ GluNa), or disodium N-lauroyl glutamate (C ₁₂ GluNa ₂ ), and the aliphatic higher alcohol was 1-tetra An alcohol composition (25° C.) was prepared in the same manner as in Test Example 3 using decanol (C ₁₄ OH).

The resulting alcoholic composition was vigorously shaken and then allowed to stand for 24 hours. Fig. 7 shows the state of the foam immediately after shaking, 1 hour later, and 24 hours later. As shown in FIG. 7, when 1-tetradecanol was blended with CTAB, C ₁₂ GluNa, or C ₁₂ GluNa ₂ , a large amount of foam remained even after 24 hours from shaking, and foam stability was extremely low. was excellent.

<Test Example 8>
The surfactant was changed to N-stearoyl-N-methyltaurate sodium (SMT), 1-tetradecanol (C ₁₄ OH) was used as the aliphatic higher alcohol, and the alcohol composition was prepared in the same manner as in Test Example 3. (25° C.) was prepared.

The resulting alcoholic composition was vigorously shaken and then allowed to stand for 1 hour. Fig. 8 shows the state of the foam immediately after shaking and after 1 hour. As shown in FIG. 8, when 1-tetradecanol was blended with SMT, a large amount of foam remained even after 1 hour from shaking, indicating extremely excellent foam stability.

<Test Example 9>
Using sodium dodecyl sulfate (SDS) or sodium N-stearoyl-N-methyltaurate (SMT) as the surfactant, and using 1-tetradecanol (C ₁₄ OH) as the aliphatic higher alcohol, Test Example An alcohol composition (25° C.) was prepared in the same manner as in 3.

A ball-on-plate type friction and wear analyzer (manufactured by Kyowa Interface Science Co., Ltd., TSf- 503) was used to measure the dynamic friction coefficient at room temperature. A stainless steel R-contact and a chemically oxidized silicon wafer were used for the measurement, and the amount of liquid or foam was set to 3 mL, and the measurement was performed under the conditions of a load of 100 g, a sliding speed of 10 mm/s, and a sliding distance of 10 cm. For comparison, the dynamic friction coefficient was similarly measured for a commercially available high-concentration ethanol-containing gel disinfectant, a low-concentration ethanol-containing foam disinfectant, and a 40% by volume ethanol aqueous solution.

FIG. 9 shows the measurement results of the dynamic friction coefficient. As shown in FIG. 9, all alcohol compositions exhibited low dynamic friction coefficients. In particular, the alcoholic foam composition containing 1-tetradecanol with SMT had good frictional properties comparable to commercial low-concentration ethanol-containing foam disinfectants.

<Test Example 10>
Sodium dodecyl sulfate (SDS) was used as the surfactant, 1-tetradecanol (C ₁₄ OH) was used as the aliphatic higher alcohol, and an alcohol composition (25°C) was prepared in the same manner as in Test Example 3. prepared.

After vigorously shaking the resulting alcohol composition, it was allowed to stand still for 30 seconds, and the state of foam was observed. Furthermore, this alcohol composition was stored at −10° C. for 3 days, then stored in a constant temperature bath at 25° C. for 3 to 24 hours, and changes in foamability and foam stability were observed. The results are shown in FIG. As shown in FIG. 10, when the alcohol composition was stored at −10° C. for 3 days, precipitation occurred and the foaming property was lost, but when the composition was returned to room temperature (25° C.), the foaming property and foam stability were restored. .

<Test Example 11>
Sodium N-stearoyl-N-methyltaurate (SMT) and/or lauramidopropyl betaine (betaine) is used as the surfactant, and 1-tetradecanol (C ₁₄ OH) is used as the aliphatic higher alcohol. Then, in the same manner as in Test Example 8, an alcohol composition (25°C) was prepared.

The resulting alcoholic composition was vigorously shaken and then allowed to stand for 24 hours. Fig. 11 shows the state of the foam immediately after shaking, 30 seconds later, and 24 hours later. As shown in FIG. 11, when 1-tetradecanol was blended with SMT and/or betaine, a large amount of foam remained even after 24 hours from shaking, indicating extremely excellent foam stability.

Although illustration is omitted, a similar experiment was performed by changing the total concentration of SMT, betaine, and 1-tetradecanol to 2% by mass. It was confirmed that

Claims (3)

Containing a lower alcohol having 1 to 4 carbon atoms, water, an aliphatic higher alcohol having 12 to 20 carbon atoms, and a surfactant other than the aliphatic higher alcohol,
The content of the lower alcohol is 20% by volume or more,
the surfactant is at least one selected from anionic surfactants, cationic surfactants, and amphoteric surfactants;
An alcohol composition in which the molar ratio of the aliphatic higher alcohol and the surfactant is 1:3 to 3:1 . 2. The alcoholic composition according to claim 1, wherein said lower alcohol is ethanol. 3. The alcohol composition according to claim 1 or 2, wherein the fatty higher alcohol is a linear saturated fatty alcohol.

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