JP7259448B2 - Biological information measuring device and biological information measuring system - Google Patents

Description

The present invention relates to a biological information measuring device and a biological information measuring system.

A method of acquiring biometric information emitted by a living body as a signal is known.

In order to determine whether a living body is ill or not, there is a case where neural activity or the like is evaluated. Therefore, a biomagnetic measuring device or the like measures the nerve magnetic field. In such measurements, a method of displaying a plurality of biological information signals such as brain magnetic field data and electroencephalogram data in parallel and emphasizing a specified portion is known (see, for example, Patent Document 1). ).

Among biometric information, magnetic field signals emitted from a living body often have weak signal strength. Therefore, it is desirable to measure the magnetic field signal emitted from the living body so that the signal strength is as strong as possible.

The present invention has been made under such circumstances, and its object is to increase the signal strength of the magnetic field signal emitted from the living body to be measured.

In order to solve the above technical problems, a biological information measuring device according to one aspect of the present invention is a biological information measuring device for measuring a living body,
a first biological signal acquisition unit that acquires a first biological signal indicating a first measurement result of measuring a magnetic field signal emitted from the living body;
a second biosignal acquisition unit that acquires a second biosignal indicating a second measurement result of measuring the action potential of the nerve or muscle of the living body;
a stimulation unit that electrically stimulates the living body;
a judgment unit that changes the stimulus and judges that the nerve of the living body has fired based on the second measurement result;
a trigger unit that issues a trigger when the determination unit determines that the nerve of the living body has fired;
A control unit that acquires the first biosignal based on the trigger, or performs output based on the first biosignal acquired based on the trigger .

The signal strength of the magnetic field signal emitted from the living body to be measured can be increased.

It is a block diagram which shows the structural example of a biological information measuring device. FIG. 4 is a schematic diagram illustrating how electrodes of a nerve stimulator are attached to the knee joint of a subject. It is a figure which shows the example of a 2nd biological information measuring device and an electrical stimulator. FIG. 10 is a diagram showing an example of determining whether or not nerves of a living body are firing; It is a figure which shows the example of a 2nd measurement result. It is a figure which shows the example which acquires a 1st biomedical signal based on a trigger. It is a functional block diagram which shows the functional structural example of a biological information measuring device. It is a flowchart which shows the example of the biological information measuring method by a biological information measuring device.

Hereinafter, embodiments will be described with reference to the drawings. In addition, in each drawing, the same code|symbol may be attached|subjected to the same structure and the overlapping description may be abbreviate|omitted.

<Configuration example of biological information measuring device>
FIG. 1 is a block diagram showing a configuration example of a biological information measuring device. For example, the biological information measuring device 10 is configured to include an information processing device M1, a first biological information acquiring device M2, a second biological information acquiring device M3, an electrical stimulation device M4, and the like, as shown.

The information processing device M1 is, for example, a PC (Personal Computer) or the like. Specifically, the information processing device M1 has a hardware configuration including, for example, a CPU (Central Processing Unit, hereinafter referred to as "CPUM11"), a storage device M12, an output device M13, an input device M14, and the like.

CPUM 11 is an example of an arithmetic device and a control device.

The storage device M12 is, for example, a main storage device such as a memory and an auxiliary storage device such as a hard disk. For example, the storage device M12 stores data indicating measurement results and the like by the first biometric information acquisition device M2 or the second biometric information acquisition device M3. The storage device M12 may be configured to store data while the measurement results are being acquired, or may be configured to store data at a specified point in time.

The output device M13 is, for example, a display. Therefore, the output device M13 outputs the signals acquired by the first biometric information acquisition device M2 or the second biometric information acquisition device M3 or the like as a graph or the like.

The input device M14 is, for example, an interface such as a keyboard or mouse.

<About stimulation>
Any stimulus may be used as long as it can stimulate nerves. An example of using electrical stimulation will be described below. However, the stimulation may be magnetic stimulation or the like.

<Regarding the magnetic field signal emitted from the living body>
The magnetic field signal emitted from the living body is, for example, a signal indicating the measurement result of the nerve magnetic field (hereinafter referred to as "neural magnetic field signal"). A nerve magnetic field signal will be described below as an example. However, the magnetic field signal emitted from the living body is not limited to the neural magnetic field signal. For example, the magnetic field signal emitted from the living body may be a signal or the like indicating the measurement result of the magnetic field emitted from a living body part other than nerves such as muscles.

<Example of first biometric information acquisition device>
For example, the first biometric information acquiring device M2 is a device as follows.

FIG. 2 is a schematic diagram illustrating how electrodes of a nerve stimulator are attached to the knee joint of a subject. Moreover, FIG. 2 is a figure which shows the example of a 1st biometric information measuring device. The illustrated example is an example of how the electrodes 310 (electrodes 311, 312, 313 and 314 in the drawing) of the nerve stimulator 30 are attached to the knee joint of the subject MN. The electrodes 310 are placed, for example, in contact with the skin of the subject MN. The electrode 311 serving as a stimulating cathode and the electrode 312 serving as a stimulating anode are arranged with the intention of electrically stimulating the peroneal nerve and inducing nerve activity by being supplied with current from the current supply unit 320 . The electrode 313 serving as the detection cathode and the electrode 314 serving as the detection anode are arranged with the intention of detecting the action potential of the muscle innervated by the peroneal nerve. Thus, in this example, by measuring the action potential of the muscle innervated by the peroneal nerve, which is the target of stimulation, it is possible to ascertain whether or not nerve activity has been appropriately induced by the electrical stimulation.

The trigger signal generator 330 is a mechanism that generates a trigger signal according to the current supply timing of the current supply unit 320 . The trigger signal generated by the trigger signal generating section 330 is transmitted to the signal processing section through the signal line 63 and processed by the signal processing section and the arithmetic device.

The electromyograph 340 is a device that measures action potentials between the electrodes 313 and 314 . The electromyograph 340 transmits measurement signals to the control unit 350 and also transmits measurement signals to the signal processing unit via the signal line 64 . A measurement signal obtained from the electromyograph 340 is processed by a signal processing unit and an arithmetic unit.

The control unit 350 is an information processing device that transmits and receives commands and data to and from the current supply unit 320 and the electromyograph 340 . For example, the control unit 350 controls operations of the current supply unit 320 , the electromyograph 340 and the trigger signal generation unit 330 . The control unit 350 can be configured to include, for example, a CPU, a ROM (Read Only Memory), a RAM (Random Access Memory), a main memory, and the like.

In this case, various functions of the control unit 350 can be implemented by reading a program recorded in a ROM or the like into a main memory and executing the program by the CPU. The CPU of the control unit 350 can read data from the RAM and store data as necessary. However, part or all of the control unit 350 may be realized only by hardware. Also, the control unit 350 may be physically configured by a plurality of devices or the like. Also, the control unit 350 may include a hard disk device, an optical disk device, or the like.

Hereinafter, the measurement result measured by the first biological information measuring device as illustrated will be described as an example of the first measurement result.

<Example of second biological information measuring device and electrical stimulation device>
For example, the second biometric information acquiring device M3 is a device as follows.

FIG. 3 is a diagram showing an example of a second biological information measuring device and an electrical stimulation device. For example, the second biological information measuring device is the recording electrode EP1 or the like. Moreover, an electrical stimulator is stimulation electrode EP2 grade|etc., for example.

The recording electrode EP1 measures action potentials of nerves or muscles of the subject MN, for example, at positions as shown. Specifically, FIG. 3A is an example of measuring action potentials of muscles. On the other hand, FIG. 3B is an example of measuring nerve action potentials. Hereinafter, in the example shown in FIG. 3A, the measurement result obtained by the recording electrode EP1 will be described as an example of the second measurement result.

The stimulation electrode EP2 provides electrical stimulation to the subject MN, for example, at the position shown.

Note that the part of the living body from which the biometric information is acquired is not limited to the hands and arms as in the above example. In other words, as long as biometric information can be acquired, the part to be measured may be another part.

The illustrated example is an example in which the stimulation electrode EP2 stimulates the median nerve at the so-called elbow. The illustrated example is an example in which the recording electrode EP1 measures the action potential of the abductor pollicis brevis muscle.

For example, the wrist may stimulate the median nerve. When measuring the electrical activity of the cervical spinal cord, it is desirable to stimulate a location closer to the cervical spine in order to increase the signal intensity. Therefore, as shown in the figure, when the median nerve is stimulated with the elbow or the like, the signal strength can be stronger than with the wrist or the like. In addition, elbows and the like are places that are easily stimulated.

<Example of judging whether or not nerves in a living body are firing>
An action potential is when a difference in membrane potential is reversed by a stimulus.

Firing is a phenomenon in which the electrical potential generated in the cell membrane reaches an action potential.

First, the biological information measuring device causes the nerves of the living body to fire with the second biological information measuring device and the electric stimulation device shown in FIG. do.

FIG. 4 is a diagram showing an example of determining whether or not nerves of a living body are firing. Hereinafter, the current value of the electricity passed through the subject by the stimulating electrode is used as an indicator of stimulation, and is indicated by the horizontal axis in the figure. On the other hand, in the figure, the vertical axis represents the measurement result measured by the recording electrode (hereinafter sometimes referred to as "measurement result for stimulation") for the current value shown on the horizontal axis.

It should be noted that the electric characteristic to be changed may not be the current value. An example in which the electrical characteristic is a current value will be described below. However, the electrical characteristic may be, for example, the time during which the stimulus is applied or the frequency of the stimulus (when the stimulus is an electrical stimulus, the frequency is frequency (Hz), etc.).

For example, the biological information measuring device changes the current value to current values A1, A2, A3, A4, A5, A6, A7 and A8 as shown in the figure to change the stimulus given to the living body.

Then, it is assumed that the measurement results for stimuli measured at respective current values are amplitudes B1, B2, B3, B4, B5, B6 and B7, for example.

As shown in the figure, even if the stimulus is changed to become stronger, the response to the stimulus, that is, the measurement result for the stimulus becomes saturated. Specifically, for example, when the current value is changed from A1 to A2, the change in response to the stimulus has a large change like the difference between the amplitudes B1 and B2. On the other hand, when the current value is changed from A6 to A7, the change with respect to stimulation is the difference between the amplitudes B6 and B7, and there is almost no change.

In this way, even if the stimulus is changed, the state in which the measurement result is difficult to change is the state in which the stimulus is the so-called maximum stimulus. A stimulus obtained by increasing the stimulus intensity of the maximum stimulus by about 20% is called "supramaximal stimulation". In the case of supramaximal stimulation, there is a high possibility that all the nerves are in a state of firing. In the illustrated example, the maximum stimulus, MX, is assumed to be the maximum stimulus.

A maximum stimulus is a stimulus in which all nerve fibers are excited and the response is constant.

In this way, when the stimulus reaches the maximum stimulus MX, even if the stimulus is changed further, there are many cases where the change in response is small. Therefore, it is desirable that the biological information measuring device can determine that the stimulus is the maximum stimulus MX.

In this example, if there is stimulation with a current value after the current value A7 at which the measurement result is saturated, the biological information measuring device determines that all the nerves of the living body are firing. Therefore, the biological information measuring device determines that the stimulus is the maximum stimulus at the current value A7.

Specifically, the biological information measuring device determines that all the nerves of the living body are firing when the amount of change in the second measurement result with respect to the amount of change in the stimulus current value is equal to or less than a preset threshold. In other words, the biological information measuring device determines that the nerves of the living body are firing when the gradient (which may be a differential value or the like) in the illustrated graph is equal to or less than a threshold.

It should be noted that the stimulus is preferably a current value obtained by multiplying the current value at which the nerve of the living body is determined to be firing as described above by a predetermined factor. The predetermined magnification is, for example, "1.2 times". That is, it is desirable that the biological information measuring device multiply the maximum stimulus by a predetermined magnification to generate the supramaximal stimulus, and apply the supramaximal stimulus to the living body. The state of a living body is affected by conditions such as physical condition and external environment. Therefore, sufficient stimulus to fire nerves in the living body may vary depending on the state of the living body. Therefore, it is desirable to multiply the value determined as described above by a predetermined factor, which is a margin for sufficient nerve firing. On the other hand, if the margin is too large and the stimulation is too large, the living body may feel pain or a large current value of electricity may flow through the living body. Therefore, it is desirable to increase the predetermined magnification by about "1.2 times", that is, by about "20 percent".

Moreover, it is desirable that the second measurement result is, for example, the difference between the high potential value and the low potential value of the action potential at the specified time as follows.

FIG. 5 is a diagram showing an example of the second measurement result. The second measurement result, that is, the amplitude (the value on the vertical axis) in FIG. 4 is the difference DF between the high potential value EMX and the low potential value EMN at the specified time TS.

The specified time TS is set in advance, for example. As shown, the designated time TS is, for example, the latency of an action potential.

The high potential value EMX is a potential value higher than the baseline potential among the action potentials measured at the specified time TS.

The low potential value EMN is a potential value lower than the baseline potential among the action potentials measured during the specified time TS.

Then, the difference DF is calculated by, for example, calculating the difference between the high potential value EMX and the low potential value EMN.

It should be noted that the method of calculating the amplitude may be a method other than the one shown in the figure.

Thus, if the second measurement result, such as the difference DF between the high potential value EMX and the low potential value EMN at the specified time TS, is automatically calculated, the maximum stimulus, etc., can be easily found.

As described above, when it is determined that the nerves of the living body are firing, the biological information measuring device generates a trigger (hereinafter, sometimes simply referred to as "trigger TRG") to notify that the nerves of the living body are firing. ). For example, the trigger is a trigger signal or the like. Then, when the trigger is detected, the biological information measuring device measures the first biological information, as shown in FIG. 1, for example. Therefore, the biological information measuring device outputs measurement results as follows, for example.

FIG. 6 is a diagram showing an example of acquiring the first biosignal based on a trigger. First, for example, as shown in FIG. 6A, the second biological information acquisition device acquires the second biological signal SIG2. Thus, when the second biological signal SIG2 is generated, the biological information measuring device can calculate the second measurement result as shown in FIG. 5 and the like. In the state in which the second measurement result is obtained in this way, the biological information measuring device changes the stimulus. By changing the stimulation in this way, for example, as shown in FIG. 4, the biological information measuring device can determine whether or not the nerves of the living body are firing.

Next, when the biological information measuring device determines that the nerves of the living body are firing, it emits a trigger TRG to notify that the nerves of the living body are firing. When such a trigger TRG occurs, the biological information measurement device acquires the first biological signal SIG1.

The first biomedical signal SIG1 is a signal that often has a weak signal strength, that is, a low S/N ratio. On the other hand, when the nerves of the living body are firing, the signal intensity of the first biological signal SIG1 can be increased.

Further, when the nerves of the living body are firing, it can be said that the first biological signal SIG1 is under similar conditions. Therefore, as described above, when notified by the trigger TRG, the nerves of the living body are firing, and the first biological signal SIG1 can be stably obtained under almost the same conditions.

<Example of functional configuration>
FIG. 7 is a functional block diagram showing a functional configuration example of the biological information measuring device. For example, the biological information measuring device 10 has a functional configuration including a first biological signal acquisition section FN1, a second biological signal acquisition section FN2, a stimulation section FN3, a determination section FN4, a trigger section FN5, a control section FN6, and the like. The illustrated functional configuration will be described below as an example.

The first biosignal acquisition unit FN1 performs a first biosignal acquisition procedure of acquiring a first biosignal indicating a first measurement result of measuring a nerve magnetic field of a subject MN, which is an example of a living body. For example, the first biosignal acquisition unit FN1 is realized by the device or the like shown in FIG. 2 or the like.

The second biosignal acquisition unit FN2 performs a second biosignal acquisition procedure of acquiring a second biosignal indicating a second measurement result of measuring the action potential of nerves or muscles of the subject MN. For example, the second biosignal acquisition unit FN2 is realized by the recording electrode EP1 or the like.

The stimulation unit FN3 performs a stimulation procedure of applying electrical stimulation to the subject MN. For example, the stimulation unit FN3 is realized by stimulation electrodes EP2 and the like.

The determination unit FN4 changes the stimulation given to the subject MN by the stimulation unit FN3, and performs a determination procedure for determining that the nerve of the subject MN has fired based on the second measurement result. For example, the determination unit FN4 is realized by the CPUM11 or the like.

The trigger unit FN5 performs a trigger procedure for issuing a trigger TRG when the determination unit FN4 determines that the nerve of the subject MN has fired. For example, the trigger unit FN5 is realized by the CPUM11 or the like.

Based on the trigger TRG, the control unit FN6 performs a control procedure of acquiring the first biological information signal or performing an output based on the first biological information signal. For example, the control unit FN6 is realized by the CPUM11 or the like.

For example, with the functional configuration as described above, the biological information measuring apparatus 10 performs the following processing.

<Processing example>
In step S1, the stimulator gives a stimulus to the living body. The following processes are executed under the condition that the stimulus is applied.

In step S2, the second biological information signal acquisition unit acquires a second biological signal. Then, based on the second biological signal, the biological information measuring device can obtain a second measurement result for the stimulus, as shown in FIG. 4, for example. Therefore, the biological information measuring device can determine whether or not the nerves of the living body are firing.

In step S3, the determination unit determines whether or not the nerves of the living body have fired. Specifically, for example, like the amplitude in FIG. 4, it is determined whether or not the nerves of the living body have fired based on the relationship between the stimulus and the second measurement result.

Next, when it is determined that the nerve of the living body has fired (YES in step S3), the biological information measuring device proceeds to step S5. On the other hand, if it is determined that the nerves of the living body are not firing (NO in step S3), the biological information measuring device proceeds to step S4.

In step S4, the stimulator changes the stimulus. For example, in step S4, as shown in FIG. 4, the current value and the like are changed.

Therefore, by repeating steps S2 to S4, for example, as shown in FIG. 4, each second measurement result for a plurality of stimuli is obtained. In this way, it is possible to calculate the amount of change in the second measurement result with respect to the amount of change in stimulation.

In step S5, the trigger section emits a trigger to notify that the nerve of the living body has fired. For example, the trigger is a signal or the like, and is notified to the first biosignal acquisition device, the information processing device, or the like.

In step S6, the control unit acquires the first biological information signal or performs output based on the first biological information signal. That is, for example, as shown in FIG. 6B, the first biomedical signal is acquired in a state in which the nerves of the living body, which are notified by the trigger, are firing.

As shown in FIG. 6B, the first biometric information signal obtained at the time indicated by the trigger is signal strength (vertical axis in the figure) against time (horizontal axis in the figure). ) is preferably output in the form of time-series data plotted. That is, for example, as shown in FIG. 6B, when the first biological information signal is measured by a measuring instrument such as an oscilloscope and the measurement result is displayed, the display screen when the trigger is issued may be captured.

Note that the first biological information is not limited to being measured at the time indicated by the trigger. The first biometric information signal may be obtained within a predetermined time from the time indicated by the trigger. Firing of nerves in a living body is often maintained within a predetermined period of time if the posture of the living body or the like is constant. That is, in many cases, the first biometric information can be acquired under the same conditions as the time indicated by the trigger, even if a predetermined time has passed since it was determined that the nerve of the living body had fired.

For example, the predetermined time is about 10 minutes. However, the predetermined time varies depending on, for example, changes in the posture of the living body, individual differences in the living body, external environmental conditions, physiological phenomena of the living body such as perspiration, and the like.

Alternatively, the measurement of the first biological information signal may be started after the trigger is issued. That is, in some devices, the first biological information signal and the second biological information signal cannot be measured in parallel. Therefore, the order may be such that only the second biological information signal is acquired first, and acquisition of the first biological information signal is started immediately after it is determined that the nerves of the living body have fired.

On the other hand, the first biological information signal may be acquired and stored at a time point other than the time point indicated by the trigger. That is, the first biometric information signal may be obtained at multiple points in time. Then, the output may be such that a mark or the like is added to indicate which first biological information signal is acquired at the time when the trigger is issued, that is, when it is determined that the nerve is firing.

With the above configuration, the biological information measuring device can determine whether or not the nerves of the living body are firing based on the second biological information. Then, while the nerves of the living body are firing, the first biological information is measured to obtain the first measurement result. The first biological information signal indicating the first measurement result, that is, the nerve magnetic field signal, often has a low signal strength. However, if all the nerves in the living body are firing, the signal strength of the nerve magnetic field signal will be strong. Therefore, by acquiring the neural magnetic field signal aiming at a state in which all the nerves of the living body are firing, the signal strength of the neural magnetic field signal to be measured can be increased.

<Other embodiments>
Each device need not be one device. That is, each device may be a combination of multiple devices. Note that the configuration may further include devices other than those shown in the drawings.

Note that the information processing device may be, for example, a medical device, a server, a notebook PC, a mobile phone, a smart phone, a tablet terminal, a wearable PC, a desktop PC, or the like.

Also, the biological information measuring device or the biological information measuring system may utilize AI (Artificial Intelligence) or the like. That is, the biological information measuring device or biological information measuring system may use machine learning or the like for processing such as determination. For example, it may be possible to learn from past data or the like what is the case when nerves are firing.

All or part of each process according to the present invention may be written in a low-level language or a high-level language and implemented by a program for causing a computer to execute the biological information measuring method. That is, the program is a computer program for causing a computer such as a biological information measuring device or a biological information measuring system to execute each process.

Therefore, when the biological information measuring method is executed based on the program, the computing device and control device of the computer perform calculation and control based on the program in order to execute each process. In addition, a storage device included in the computer stores data used for processing based on a program in order to execute each processing.

Also, the program can be recorded on a computer-readable recording medium and distributed. Note that the recording medium is a medium such as a magnetic tape, flash memory, optical disk, magneto-optical disk, or magnetic disk. Additionally, the program can be distributed over telecommunications lines.

Note that the embodiment according to the present invention may be realized by a biological information measuring system having a plurality of information processing devices. In addition, the biological information measurement system may execute each processing and data storage redundantly, distributedly, in parallel, virtualized, or a combination thereof.

Although the present invention has been described above based on each embodiment, the present invention is not limited to the requirements shown in the above embodiments. These points can be changed within the scope of the present invention, and can be determined appropriately according to the application form.

10 Biological information measuring device 201 Projection 311 Electrode 312 Electrode 313 Electrode 314 Electrode 315 Electrode 316 Electrode A1 Current value A2 Current value A3 Current value A4 Current value A5 Current value A6 Current value A7 Current value A8 Current value B1 Amplitude B2 Amplitude B3 Amplitude B4 Amplitude B5 Amplitude B6 Amplitude B7 Amplitude DF Difference EMN Low potential value EMX High potential value EP1 Recording electrode EP2 Stimulation electrode FN1 First biosignal acquisition unit FN2 Second biosignal acquisition unit FN3 Stimulation unit FN4 Determination unit FN5 Trigger unit FN6 Control unit M1 Information processing device M2 First biological information acquisition device M3 Second biological information acquisition device M4 Electrical stimulation device M12 Storage device M13 Output device M14 Input device MN Subject MX Maximum stimulation SIG1 First biological signal SIG2 Second biological signal TRG Trigger TS Designation time

JP 2018-153614 A

Claims (9)

A biological information measuring device for measuring a living body,
a first biological signal acquisition unit that acquires a first biological signal indicating a first measurement result of measuring a magnetic field signal emitted from the living body;
a second biosignal acquisition unit that acquires a second biosignal indicating a second measurement result of measuring the action potential of the nerve or muscle of the living body;
a stimulation unit that stimulates the living body;
a judgment unit that changes the stimulus and judges that the nerve of the living body has fired based on the second measurement result;
a trigger unit that issues a trigger when the determination unit determines that the nerve of the living body has fired;
A biological information measuring device, comprising: a control unit that acquires the first biological signal based on the trigger, or performs output based on the first biological signal that is acquired based on the trigger . The determination unit
2. The biological information measuring device according to claim 1, wherein when it is determined that the stimulus is the maximum stimulus, it is determined that the nerve of the living body has fired. Based on the amount of change in the second measurement result with respect to the amount of change in the electrical properties of the stimulus,
The determination unit
3. The biological information measuring device according to claim 1, wherein when it is determined that the stimulus is the maximum stimulus, it is determined that the nerve of the living body has fired. The second measurement result is
4. The biological information measuring device according to any one of claims 1 to 3, wherein the difference is a difference between a high potential value and a low potential value of the action potential at a specified time. The control unit
5. Any one of claims 1 to 4, wherein the signal intensity of the first biological signal acquired within a predetermined time from the point indicated by the trigger is plotted against time and output as time-series data. 2. The biological information measuring device according to 1. 6. The biological information measuring device according to any one of claims 1 to 5, wherein the magnetic field signal indicates a nerve magnetic field. The biological information measuring device according to any one of claims 1 to 6, wherein the stimulator provides electrical stimulation. The determination unit
When the amount of change in the second measurement result is equal to or less than a preset threshold, it is determined that the stimulus has become the maximum stimulus,
The stimulator is
When the determining unit determines that the stimulus has become the maximum stimulus, a supramaximal stimulus is generated by multiplying the maximum stimulus by a predetermined magnification, and the supramaximal stimulus is applied as the stimulus . 8. The biological information measuring device according to any one of items 1 to 7. A biological information measurement system for measuring a living body,
a first biological signal acquisition unit that acquires a first biological signal indicating a first measurement result of measuring a magnetic field signal emitted from the living body;
a second biosignal acquisition unit that acquires a second biosignal indicating a second measurement result of measuring the action potential of the nerve or muscle of the living body;
a stimulation unit that electrically stimulates the living body;
a judgment unit that changes the stimulus and judges that the nerve of the living body has fired based on the second measurement result;
a trigger unit that issues a trigger when the determination unit determines that the nerve of the living body has fired;
A biological information measurement system, comprising: a control unit that acquires the first biological signal based on the trigger, or performs an output based on the first biological signal that is acquired based on the trigger .

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