JP7289230B2 - tissue reinforcement - Google Patents
tissue reinforcement Download PDFInfo
- Publication number
- JP7289230B2 JP7289230B2 JP2019128430A JP2019128430A JP7289230B2 JP 7289230 B2 JP7289230 B2 JP 7289230B2 JP 2019128430 A JP2019128430 A JP 2019128430A JP 2019128430 A JP2019128430 A JP 2019128430A JP 7289230 B2 JP7289230 B2 JP 7289230B2
- Authority
- JP
- Japan
- Prior art keywords
- tissue
- reinforcing material
- nonwoven fabric
- tissue reinforcing
- shape
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000002787 reinforcement Effects 0.000 title description 2
- 239000012779 reinforcing material Substances 0.000 claims description 50
- 239000004745 nonwoven fabric Substances 0.000 claims description 23
- 230000002745 absorbent Effects 0.000 claims 1
- 239000002250 absorbent Substances 0.000 claims 1
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Polymers OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 14
- 229920000954 Polyglycolide Polymers 0.000 description 14
- 238000000034 method Methods 0.000 description 10
- 238000010586 diagram Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 4
- 210000001124 body fluid Anatomy 0.000 description 3
- 239000010839 body fluid Substances 0.000 description 3
- 239000000155 melt Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 229920000747 poly(lactic acid) Polymers 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 230000003014 reinforcing effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 108010022355 Fibroins Proteins 0.000 description 1
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 238000001523 electrospinning Methods 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 229920001519 homopolymer Polymers 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
Images
Landscapes
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
Description
本発明は、複数方向の伸縮性に優れ、組織の形状に追従して脆弱化した組織をより確実に補強できる組織補強材に関する。 BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a tissue reinforcing material that has excellent stretchability in multiple directions and that can follow the shape of the tissue and more reliably reinforce weakened tissue.
外科手術においては、手術部位である切除面の保護、体液リーク予防、縫合部位の補強を目的として、補強材を用いて組織を補強することがある。組織からの剥離を抑えて高い補強効果を得るためには、組織補強材を組織としっかり密着させる必要がある。そのためには、組織の形状に追従できる高い伸縮性が必要となる。そこで、組織補強材に切り込みを入れることで伸縮性を向上させる試みがなされている（例えば、特許文献１）。しかしながら、従来の切れ込みを有する組織補強材は、想定したほど伸縮しなかったり、一方向にはよく伸縮するものの、それと垂直な方向には充分に伸縮しなかったりするものが多く、複数方向に対する伸縮性の高い組織補強材が求められている。 BACKGROUND ART In surgical operations, a reinforcing material is sometimes used to reinforce tissue for the purpose of protecting the resected surface, which is a surgical site, preventing body fluid leakage, and reinforcing sutured sites. In order to suppress detachment from the tissue and obtain a high reinforcing effect, it is necessary to firmly adhere the tissue reinforcing material to the tissue. For that purpose, high stretchability that can follow the shape of the tissue is required. Therefore, attempts have been made to improve stretchability by making cuts in the tissue reinforcing material (for example, Patent Document 1). However, many conventional tissue reinforcing materials with cuts do not stretch as much as expected, or stretch well in one direction but do not stretch sufficiently in the direction perpendicular to it, and stretch in multiple directions. There is a demand for a tissue reinforcing material with high strength.
本発明は、複数方向の伸縮性に優れ、組織の形状に追従して脆弱化した組織をより確実に補強できる組織補強材を提供することを目的とする。 SUMMARY OF THE INVENTION An object of the present invention is to provide a tissue reinforcing material that has excellent stretchability in multiple directions and that can follow the shape of the tissue and more reliably reinforce weakened tissue.
本発明は、生体吸収性の不織布からなる組織補強材であって、前記組織補強材は、２本の対向する線と、該２本の対向する線の間を結び該２本の対向する線の先端を通らない線とを含む形状を基本単位とする、前記生体吸収性不織布を厚さ方向に貫通する切り込みパターンを有し、前記切り込みパターンは、前記生体吸収性の不織布の一方向をＸ方向、前記Ｘ方向に垂直な方向をＹ方向としたときに、前記Ｘ方向及び前記Ｙ方向と平行な直線上に配置された複数の前記基本単位からなる行及び列から構成され、各行及び各列の前記基本単位は、隣接する行および列の隣接する２つの前記基本単位間を跨ぐように配置されている組織補強材である。
以下に本発明を詳述する。
The present invention is a tissue reinforcing material comprising a bioabsorbable nonwoven fabric, the tissue reinforcing material comprising two opposing lines and a connecting line between the two opposing lines. A cut pattern that penetrates the bioabsorbable nonwoven fabric in the thickness direction, the cut pattern having a shape that includes a line that does not pass through the tip of the bioabsorbable nonwoven fabric in the thickness direction. When the direction perpendicular to the X direction is defined as the Y direction, each row and column consists of a plurality of basic units arranged on a straight line parallel to the X direction and the Y direction. The elementary units of a column are tissue reinforcements that straddle between two adjacent elementary units of adjacent rows and columns.
The present invention will be described in detail below.
本発明者らは鋭意検討を進めた結果、組織補強材に特定パターンとなるような切り込みを入れることで、縦及び横の両方向に対して高い伸縮性を示すことを見出した。その結果、組織の形状に追従し、脆弱化した組織をより確実に補強できる組織補強材が得られることを見出し本発明を完成させるに至った。 As a result of intensive studies, the inventors of the present invention have found that the tissue reinforcing material exhibits high elasticity in both the vertical and horizontal directions by making cuts in a specific pattern. As a result, the inventors have found that a tissue reinforcing material can be obtained that conforms to the shape of the tissue and can more reliably reinforce the weakened tissue, leading to the completion of the present invention.
本発明の組織補強材は、生体吸収性の不織布（以下、単に不織布ともいう）からなる。
組織補強材を生体吸収性の不織布とすることで、移植後に徐々に生体に吸収され、やがて消滅し自己組織に置換される。従って、慢性期の異物反応の軽減や感染の温床になるリスクが低減されることなる。
The tissue reinforcing material of the present invention consists of a bioabsorbable nonwoven fabric (hereinafter simply referred to as nonwoven fabric).
By using a bioabsorbable nonwoven fabric as the tissue reinforcing material, it is gradually absorbed by the body after transplantation, and eventually disappears and is replaced by the autologous tissue. Therefore, foreign body reaction in the chronic stage is reduced and the risk of becoming a breeding ground for infection is reduced.
上記不織布を構成する生体吸収性材料は、例えば、ポリグリコリド、ポリラクチド（Ｄ、Ｌ、ＤＬ体）、グリコリド－ラクチド（Ｄ、Ｌ、ＤＬ体）共重合体、グリコリド－Ε－カプロラクトン共重合体、ラクチド（Ｄ、Ｌ、ＤＬ体）－Ε－カプロラクトン共重合体、ポリ（Ｐ－ジオキサノン）、グリコリド－ラクチド（Ｄ、Ｌ、ＤＬ体）－Ε－カプロラクトン共重合体等の合成吸収性高分子が挙げられる。これらは単独で用いられてもよく、２種以上が併用されてもよい。なかでも、適度の強度と柔軟性を発揮することができ、かつ、適度な生体反応を惹起して組織の修復を促進することができることから、ポリグリコリド、ポリラクチド（Ｌ体）、ラクチド（Ｄ、Ｌ、ＤＬ体）－Ε－カプロラクトン共重合体が好適であり、適度な分解挙動を示すことから、ポリグリコリドがより好適である。
また、上記生体吸収性材料としては、シルクフィブロイン、コラーゲン、ゼラチン、キチン、キトサン、フィブリン等の天然吸収性高分子を用いることもできる。更に、上記合成吸収性高分子と上記天然吸収性高分子を併用してもよい。
Bioabsorbable materials constituting the nonwoven fabric include, for example, polyglycolide, polylactide (D, L, DL forms), glycolide-lactide (D, L, DL forms) copolymers, glycolide-Ε-caprolactone copolymers, Synthetic absorbable polymers such as lactide (D, L, DL forms)-Ε-caprolactone copolymers, poly(P-dioxanone), glycolide-lactide (D, L, DL forms)-Ε-caprolactone copolymers mentioned. These may be used alone or in combination of two or more. Among them, polyglycolide, polylactide (L form), lactide (D, L, DL form)-E-caprolactone copolymer is preferred, and polyglycolide is more preferred because it exhibits moderate decomposition behavior.
As the bioabsorbable material, natural absorbable polymers such as silk fibroin, collagen, gelatin, chitin, chitosan, and fibrin can also be used. Furthermore, the synthetic absorbable polymer and the natural absorbable polymer may be used in combination.
上記生体吸収性材料としてポリグリコリド（グリコリドのホモポリマー又はコポリマー）を用いる場合、ポリグリコリドの重量平均分子量の好ましい下限は３００００、好ましい上限は１００００００である。上記ポリグリコリドの重量平均分子量が３００００以上であると、組織補強材としての充分な強度を発揮でき、１００００００以下であると、適度な生体反応を惹起して組織の修復を促進し、分解することで長期間の異物としての残存が無く速やかに生体組織に置き換わる。上記ポリグリコリドの重量平均分子量のより好ましい下限は５００００、より好ましい上限は３０００００である。 When polyglycolide (a homopolymer or copolymer of glycolide) is used as the bioabsorbable material, the preferred lower limit of the weight average molecular weight of polyglycolide is 30,000, and the preferred upper limit is 1,000,000. When the weight-average molecular weight of the polyglycolide is 30,000 or more, it can exhibit sufficient strength as a tissue reinforcing material, and when it is 1,000,000 or less, it induces an appropriate biological reaction to promote tissue repair and decomposition. It is quickly replaced by living tissue without remaining as a foreign substance for a long period of time. A more preferable lower limit of the weight average molecular weight of the polyglycolide is 50,000, and a more preferable upper limit thereof is 300,000.
本発明の組織補強材がポリグリコリドからなる場合、ポリグリコリドのメルトフローレートの好ましい上限は１５ｇ／１０ｍｉｎ、好ましい下限は２ｇ／１０ｍｉｎである。上記ポリグリコリドのメルトフローレートがこの範囲内であると、組織補強材としての充分な強度を発揮できるとともに、適度な生体反応を惹起して組織の修復を促進し、分解することで長期間の異物としての残存が無く速やかに生体組織に置き換わる。上記ポリグリコリドのメルトフローレートのより好ましい上限は１０ｇ／１０ｍｉｎ、より好ましい下限は４ｇ／１０ｍｉｎである。 When the tissue reinforcing material of the present invention comprises polyglycolide, the preferred upper limit of the polyglycolide melt flow rate is 15 g/10 min, and the preferred lower limit is 2 g/10 min. When the melt flow rate of the polyglycolide is within this range, it is possible to exhibit sufficient strength as a tissue reinforcing material, induce an appropriate biological reaction to promote tissue repair, and decompose tissue for a long period of time. It does not remain as a foreign substance and is quickly replaced with living tissue. A more preferable upper limit of the melt flow rate of the polyglycolide is 10 g/10 min, and a more preferable lower limit is 4 g/10 min.
上記不織布の目付は特に限定されないが、好ましい下限は５ｇ／ｍ２、好ましい上限は３００ｇ／ｍ２である。上記不織布の目付が５ｇ／ｍ２未満であると、生体組織補強材としての強度が不足し、脆弱した組織を補強できないことがあり、３００ｇ／ｍ２を超えると、組織への接着性が悪くなることがある。上記不織布の目付のより好ましい下限は１０ｇ／ｍ２、より好ましい上限は１００ｇ／ｍ２である。 The basis weight of the nonwoven fabric is not particularly limited, but the preferred lower limit is 5 g/m 2 and the preferred upper limit is 300 g/m 2 . If the nonwoven fabric has a basis weight of less than 5 g/m 2 , the strength as a biological tissue reinforcing material may be insufficient, and fragile tissue may not be reinforced. can be. A more preferable lower limit of the basis weight of the nonwoven fabric is 10 g/m 2 , and a more preferable upper limit is 100 g/m 2 .
上記不織布の空隙率は特に限定されないが、好ましい下限は２０％、好ましい上限は９０％である。上記不織布の空隙率がこの範囲内であると、組織補強材としての充分な強度と、生体組織への接着性、再生組織侵入を両立することができる。上記不織布の空隙率のより好ましい下限は６０％、より好ましい上限は８０％である。 Although the porosity of the nonwoven fabric is not particularly limited, the preferred lower limit is 20% and the preferred upper limit is 90%. When the porosity of the nonwoven fabric is within this range, it is possible to achieve both sufficient strength as a tissue reinforcing material, adhesion to living tissue, and penetration into regenerated tissue. A more preferable lower limit of the porosity of the nonwoven fabric is 60%, and a more preferable upper limit thereof is 80%.
上記不織布を製造する方法は特に限定されず、例えば、エレクトロスピニングデポジション法、メルトブロー法、ニードルパンチ法、スパンボンド法、フラッシュ紡糸法、水流交絡法、エアレイド法、サーマルボンド法、レジンボンド法、湿式法等の従来公知の方法を用いることができる。 The method for producing the nonwoven fabric is not particularly limited, and examples thereof include an electrospinning deposition method, a melt blow method, a needle punch method, a spunbond method, a flash spinning method, a hydroentanglement method, an airlaid method, a thermal bond method, a resin bond method, A conventionally known method such as a wet method can be used.
本発明の組織補強材は、２本の対向する線（以下、線Ａともいう）と、該２本の対向する線の間を結び該２本の対向する線の先端を通らない線（以下、線Ｂともいう）とを含む形状を基本単位とする、上記生体吸収性不織布を厚さ方向に貫通する切り込みパターンを有し、上記切り込みパターンは、上記生体吸収性の不織布の一方向をＸ方向、上記Ｘ方向に垂直な方向をＹ方向としたときに、上記Ｘ方向及び上記Ｙ方向と平行な直線上に配置された複数の上記基本単位からなる行及び列から構成され、各行及び各列の上記基本単位は、隣接する行および列の隣接する２つの上記基本単位間を跨ぐように配置されている。
このような切り込みパターンを有することで、上記Ｘ方向及びＹ方向の両方向に対して高い伸縮性を示し、組織の形状に充分に追随することができる。その結果、組織補強材が組織と充分に密着して脆弱化した組織をより確実に補強することができる。ここで「結び」とは、上記線Ｂが上記２本の線Ａと接続されている状態を指し、上記線Ｂは上記２本の線Ａを貫通していてもよい。
The tissue reinforcing material of the present invention consists of two opposing lines (hereinafter also referred to as lines A) and a line connecting between the two opposing lines and not passing through the ends of the two opposing lines (hereinafter referred to as lines A). , also referred to as line B), and has a cut pattern that penetrates the bioabsorbable nonwoven fabric in the thickness direction, and the cut pattern has one direction of the bioabsorbable nonwoven fabric in the X direction. When the direction perpendicular to the X direction is defined as the Y direction, each row and column consists of a plurality of basic units arranged on a straight line parallel to the X direction and the Y direction. The basic unit of a column is arranged so as to straddle between two adjacent basic units of adjacent rows and columns.
By having such a cut pattern, it exhibits high stretchability in both the X direction and the Y direction, and can sufficiently follow the shape of the tissue. As a result, the tissue reinforcing material can sufficiently adhere to the tissue to more reliably reinforce the weakened tissue. Here, "knot" refers to a state in which the line B is connected to the two lines A, and the line B may pass through the two lines A.
ここで、本発明の組織補強材の一例として、後述する実施例において作製した本発明の組織補強材の模式図を図１（ａ）～図３（ａ）に示した。
上記基本単位としては、例えば、図１（ａ）、図２（ａ）に示すような漢字の王の字型の形状や、図３（ａ）に示すようなアルファベットのＨ字型の形状が挙げられる。ここで、王の字型やＨ字型は直線で構成されているものも曲線で構成されているものも含む。
また、図２（ａ）、図３（ａ）に示すように、上記基本単位は、王の字型やＨ字型の端部に更に切り込みを入れた形状であることが好ましい。各線の端部に更に切り込みを入れることで、Ｘ方向とＹ方向の伸縮具合をより均等にしたり、より伸縮性を高めたりすることができる。
Here, as an example of the tissue reinforcing material of the present invention, schematic diagrams of the tissue reinforcing material of the present invention produced in Examples described later are shown in FIGS. 1(a) to 3(a).
As the basic unit, for example, the shape of the Chinese character "O" as shown in FIGS. mentioned. Here, the king shape and the H shape include straight lines and curved lines.
Moreover, as shown in FIGS. 2(a) and 3(a), it is preferable that the basic unit has a shape obtained by further notching the ends of a king shape or an H shape. By further cutting the ends of each line, the degree of stretching in the X and Y directions can be made more uniform, or the stretchability can be increased.
上記切り込みパターンは、図１～図３に示すように、複数の上記基本単位からなる上記Ｘ方向及び上記Ｙ方向に平行な行及び列によって構成されており、かつ、各行及び各列の上記基本単位は、隣接する行および列の隣接する２つの上記基本単位間を跨ぐように配置されている。ここで、「跨ぐ」とは、ある基本単位の線Ａ（線Ｂ）を線Ａ（線Ｂ）に対して垂直な方向に平行移動したときに、隣接する行又は列中の隣接する２つの基本単位の線Ａ（線Ｂ）と重なるような配置とすることを指す。なお、上記行及び列中の上記基本単位は等間隔で配置されていてもよく不等間隔で配置されていてもよい。 As shown in FIGS. 1 to 3, the cut pattern is composed of rows and columns parallel to the X direction and the Y direction consisting of a plurality of the basic units, and the basic units in each row and each column A unit is arranged across two adjacent basic units in adjacent rows and columns. Here, "straddle" means that when a certain basic unit line A (line B) is translated in a direction perpendicular to the line A (line B), two adjacent rows or columns It refers to an arrangement that overlaps the line A (line B) of the basic unit. The basic units in the rows and columns may be arranged at equal intervals or may be arranged at unequal intervals.
上記不織布中における上記基本単位の密度は特に限定されないが、１個／１００ｃｍ２以上１０００個／１００ｃｍ２以下であることが好ましい。上記基本単位の密度が上記範囲となる切り込みパターンとすることで、より伸縮性に優れた組織補強材とすることができる。上記基本単位は５個／１００ｃｍ２以上であることがより好ましく、１０個／１００ｃｍ２以上であることが更に好ましく、５００個／１００ｃｍ２以下であることがより好ましく、１００個／１００ｃｍ２以下であることが更に好ましい。 Although the density of the basic units in the nonwoven fabric is not particularly limited, it is preferably 1 unit/100 cm 2 or more and 1000 units/100 cm 2 or less. By forming a cut pattern in which the density of the basic unit is within the above range, a tissue reinforcing material having more excellent stretchability can be obtained. The basic unit is more preferably 5 units/100 cm 2 or more, still more preferably 10 units/100 cm 2 or more, more preferably 500 units/100 cm 2 or less, and 100 units/100 cm 2 or less. It is even more preferable to have
本発明の生体組織補強材料は、外科分野において損傷又は脆弱化した臓器、組織の止血、空気漏れ防止、体液漏れ防止の為に用いる。とりわけ、呼吸器に好適に用いることができる。
本発明の生体組織補強材料は、例えば、生体組織補強材料を生理食塩水に浸漬してから患部にあてるだけで、容易に貼付することができる。また、患部に血液や体液がある場合には、これらを吸収することによっても接着力を発現することができる。また、本発明の組織補強材は、上記切り込みパターンを有しているため、組織の形状に合わせて貼付できるため、従来の組織補強材と比べてより組織と密着することから、剥離し難く脆弱化した組織をより確実に補強することができる。
The biological tissue reinforcing material of the present invention is used for hemostasis, air leakage prevention, and body fluid leakage prevention for damaged or weakened organs and tissues in the surgical field. In particular, it can be suitably used for respiratory organs.
The biological tissue reinforcing material of the present invention can be easily applied by, for example, immersing the biological tissue reinforcing material in physiological saline and applying it to the affected area. In addition, when there is blood or body fluid in the affected area, the adhesive force can also be expressed by absorbing these. In addition, since the tissue reinforcing material of the present invention has the above-described cut pattern, it can be applied according to the shape of the tissue. It is possible to more reliably reinforce the reinforced tissue.
本発明によれば、複数方向の伸縮性に優れ、組織の形状に追従して脆弱化した組織をより確実に補強できる組織補強材を提供することができる。 ADVANTAGE OF THE INVENTION According to the present invention, it is possible to provide a tissue reinforcing material that has excellent stretchability in multiple directions and can follow the shape of the tissue to more reliably reinforce weakened tissue.
以下に実施例を挙げて本発明の態様を更に詳しく説明するが、本発明はこれら実施例にのみ限定されるものではない。 EXAMPLES The aspects of the present invention will be described in more detail below with reference to Examples, but the present invention is not limited to these Examples.
（実施例１）
厚さ７０μｍのポリグリコリドからなる不織布（ネオベールナノ（ＮＶ－１０１０－Ｄ１０Ｇ）、グンゼ社製）に、図１（ａ）に示す切り込みパターンを基本単位の数が３５個／１００ｃｍ２となるように形成することで組織補強材を得た。
得られた組織補強材を縦方向及び横方向に引っ張ったところ、図１（ｂ）に示すように、縦方向横方向ともに充分な伸縮性を確認できた。
(Example 1)
A cut pattern shown in FIG. 1(a) is formed on a 70 μm-thick polyglycolide nonwoven fabric (Neovel Nano (NV-1010-D10G), manufactured by Gunze) so that the number of basic units is 35/100 cm 2 . By doing so, a tissue reinforcing material was obtained.
When the obtained tissue reinforcing material was stretched in the vertical and horizontal directions, as shown in FIG. 1(b), sufficient stretchability was confirmed in both the vertical and horizontal directions.
（実施例２）
厚さ７０μｍのポリグリコリドからなる不織布（ネオベールナノ（ＮＶ－１０１０－Ｄ１０Ｇ）、グンゼ社製）に、図２（ａ）に示す切り込みパターンを基本単位の数が２７個／１００ｃｍ２となるように形成することで組織補強材を得た。
得られた組織補強材を縦方向及び横方向に引っ張ったところ、図２（ｂ）に示すように、縦方向横方向ともに充分に伸縮し、かつ、実施例１よりも縦方向と横方向の伸縮具合が均等だった。
(Example 2)
A cut pattern shown in FIG. 2(a) is formed on a 70 μm-thick polyglycolide nonwoven fabric (Neovel Nano (NV-1010-D10G), manufactured by Gunze) so that the number of basic units is 27/100 cm 2 . By doing so, a tissue reinforcing material was obtained.
When the obtained tissue reinforcing material was stretched in the vertical and horizontal directions, as shown in FIG. Elongation was even.
（実施例３）
厚さ７０μｍのポリグリコリドからなる不織布（ネオベールナノ（ＮＶ－１０１０－Ｄ１０Ｇ）、グンゼ社製）に、図３（ａ）に示す切り込みパターンを基本単位の数が３４個／１００ｃｍ２となるように形成することで組織補強材を得た。
得られた組織補強材を縦方向及び横方向に引っ張ったところ、図３（ｂ）に示すように、縦方向横方向ともに実施例１よりも高い伸縮性が確認できた。
(Example 3)
A cut pattern shown in FIG. 3(a) is formed on a 70 μm-thick polyglycolide nonwoven fabric (Neovel Nano (NV-1010-D10G), manufactured by Gunze) so that the number of basic units is 34/100 cm 2 . By doing so, a tissue reinforcing material was obtained.
When the obtained tissue reinforcing material was stretched in the vertical and horizontal directions, it was confirmed that the stretchability was higher than that of Example 1 in both the vertical and horizontal directions, as shown in FIG. 3(b).
（比較例１）
厚さ７０μｍのポリグリコリドからなる不織布（ネオベールナノ（ＮＶ－１０１０－Ｄ１０Ｇ）、グンゼ社製）に、図４に示す切り込みパターンを形成することで組織補強材を得た。
得られた組織補強材を縦方向及び横方向に引っ張ったところ、縦方向横方向ともに伸縮しなかった。
(Comparative example 1)
A tissue reinforcing material was obtained by forming a cut pattern shown in FIG.
When the resulting tissue reinforcing material was stretched in both the longitudinal and transverse directions, it did not expand or contract in both the longitudinal and transverse directions.
（比較例２）
厚さ７０μｍのポリグリコリドからなる不織布（ネオベールナノ（ＮＶ－１０１０－Ｄ１０Ｇ）、グンゼ社製）に、図５（ａ）に示す切り込みパターンを形成することで組織補強材を得た。
得られた組織補強材を縦方向及び横方向に引っ張ったところ、図５（ｂ）に示すように、縦方向には伸縮したものの、横方向には伸縮しなかった。
(Comparative example 2)
A tissue reinforcing material was obtained by forming a cut pattern shown in FIG.
When the obtained tissue reinforcing material was stretched in the vertical and horizontal directions, it stretched in the vertical direction but did not stretch in the horizontal direction, as shown in FIG. 5(b).
（比較例３）
厚さ７０μｍのポリグリコリドからなる不織布（ネオベールナノ（ＮＶ－１０１０－Ｄ１０Ｇ）、グンゼ社製）に、図６（ａ）に示す切り込みパターンを形成することで組織補強材を得た。
得られた組織補強材を縦方向及び横方向に引っ張ったところ、図６（ｂ）に示すように、縦方向横方向ともに伸縮したものの、伸縮性は実施例１よりも小さかった。
(Comparative Example 3)
A tissue reinforcing material was obtained by forming a cut pattern shown in FIG.
When the obtained tissue reinforcing material was stretched in both the vertical and horizontal directions, it stretched in both the vertical and horizontal directions, but the stretchability was lower than that of Example 1, as shown in FIG. 6(b).
本発明によれば、複数方向の伸縮性に優れ、組織の形状に追従して脆弱化した組織をより確実に補強できる組織補強材を提供することができる。 ADVANTAGE OF THE INVENTION According to the present invention, it is possible to provide a tissue reinforcing material that has excellent stretchability in multiple directions and can follow the shape of the tissue to more reliably reinforce weakened tissue.
Claims (1)
前記組織補強材は、２本の対向する線と、該２本の対向する線の間を結び該２本の対向する線の先端を通らない線とを含む形状を基本単位とする、前記生体吸収性の不織布を厚さ方向に貫通する切り込みパターンを有し、
前記切り込みパターンは、前記生体吸収性の不織布の一方向をＸ方向、前記Ｘ方向に垂直な方向をＹ方向としたときに、前記Ｘ方向及び前記Ｙ方向に平行な直線上に配置された複数の前記基本単位からなる行及び列から構成され、
漢字の王の字型の形状、前記王の字型の端部に切り込みを入れた形状又はアルファベットのＨ字型の端部に切り込みを入れた形状であり、
各行及び各列の前記基本単位は、隣接する行および列の隣接する２つの前記基本単位間を跨ぐように配置されている
ことを特徴とする組織補強材。
A tissue reinforcing material comprising a bioabsorbable nonwoven fabric,
The tissue reinforcing material has a basic unit of a shape including two opposing lines and a line connecting between the two opposing lines and not passing through the ends of the two opposing lines. Having a cut pattern that penetrates the absorbent nonwoven fabric in the thickness direction,
The cut patterns are arranged on a straight line parallel to the X direction and the Y direction, where one direction of the bioabsorbable nonwoven fabric is the X direction and the direction perpendicular to the X direction is the Y direction. consists of rows and columns consisting of the basic units of
A shape of the Chinese character Wang, a shape with a notch at the end of the king, or a shape with a notch at the end of the letter H of the alphabet,
A tissue reinforcing material, wherein the basic units of each row and each column are arranged so as to span between two adjacent basic units of adjacent rows and columns.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019128430A JP7289230B2 (en) | 2019-07-10 | 2019-07-10 | tissue reinforcement |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019128430A JP7289230B2 (en) | 2019-07-10 | 2019-07-10 | tissue reinforcement |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021013445A JP2021013445A (en) | 2021-02-12 |
| JP7289230B2 true JP7289230B2 (en) | 2023-06-09 |
Family
ID=74531031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019128430A Active JP7289230B2 (en) | 2019-07-10 | 2019-07-10 | tissue reinforcement |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP7289230B2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7712805B2 (en) * | 2021-07-09 | 2025-07-24 | グンゼ株式会社 | Tissue reinforcement material |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001186964A (en) | 1999-12-28 | 2001-07-10 | Furukawa Electric Co Ltd:The | Futon core material |
| JP2009089899A (en) | 2007-10-09 | 2009-04-30 | Toray Fine Chemicals Co Ltd | Surgical pad material |
| JP2015107198A (en) | 2013-12-04 | 2015-06-11 | グンゼ株式会社 | Medical sheet |
| JP2017511219A (en) | 2014-04-16 | 2017-04-20 | エシコン・エンド−サージェリィ・エルエルシーＥｔｈｉｃｏｎ Ｅｎｄｏ−Ｓｕｒｇｅｒｙ， ＬＬＣ | Fastener cartridge with a fastener cavity including a fastener control feature |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH456568A4 (en) * | 1968-03-26 | 1970-08-14 |
-
2019
- 2019-07-10 JP JP2019128430A patent/JP7289230B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001186964A (en) | 1999-12-28 | 2001-07-10 | Furukawa Electric Co Ltd:The | Futon core material |
| JP2009089899A (en) | 2007-10-09 | 2009-04-30 | Toray Fine Chemicals Co Ltd | Surgical pad material |
| JP2015107198A (en) | 2013-12-04 | 2015-06-11 | グンゼ株式会社 | Medical sheet |
| JP2017511219A (en) | 2014-04-16 | 2017-04-20 | エシコン・エンド−サージェリィ・エルエルシーＥｔｈｉｃｏｎ Ｅｎｄｏ−Ｓｕｒｇｅｒｙ， ＬＬＣ | Fastener cartridge with a fastener cavity including a fastener control feature |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021013445A (en) | 2021-02-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5706498B2 (en) | Composite self-cohesive web material | |
| CN119020878A (en) | Medical devices containing poly(butylene succinate) and copolymers thereof | |
| SE1350123A1 (en) | Three-dimensional polymeric medical implants | |
| JP2009505690A (en) | Composite self-cohesive web material | |
| JP2009502329A (en) | Highly porous self-aggregating web material | |
| JP2009502327A (en) | Composite self-cohesive web material | |
| JP5015925B2 (en) | Method for producing porous self-aggregating web material | |
| US11426266B2 (en) | Medical implant | |
| CA3227438A1 (en) | Combined macro and micro-porous hybrid-scale fiber matrix | |
| JP7289230B2 (en) | tissue reinforcement | |
| CN112210888B (en) | Polylactic acid elastic non-woven material beneficial to tissue regeneration and preparation method thereof | |
| JP6771315B2 (en) | Synthetic prostheses with knitted fabrics and non-porous films, and methods of forming them | |
| WO2015051042A2 (en) | Meshes and patches for tissue repair | |
| KR101587802B1 (en) | Artificial blood scaffold and the method for manufacturing the same | |
| KR101492771B1 (en) | Nanofibrous membrane for guided bone regeneration and method of manufacturing the same | |
| Fu et al. | Centrifugal spinning-derived biomimetic aerogel for rapid hemostasis with minimal blood loss | |
| CN1372478A (en) | Artificial dura mater | |
| CN107073166A (en) | The manufacture method of regeneration base material and regeneration base material | |
| DE102007024220A1 (en) | Hemostatic fleece | |
| CN106032601A (en) | Anti-bacterium textile fabric | |
| JP6920691B2 (en) | Meniscus recycled base material | |
| JP5927061B2 (en) | Sheet hemostatic material | |
| CN107865981B (en) | Multilayer orientation nanofiber artificial dura mater and preparation method thereof | |
| JP7712805B2 (en) | Tissue reinforcement material | |
| JP7324055B2 (en) | Tissue reinforcing material and method for manufacturing tissue reinforcing material |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20220419 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20230214 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20230404 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230509 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230530 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7289230 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |