JP7304046B2 - Composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to a composition having excellent antiglycation action.

The Maillard reaction is a protein saccharification reaction in which the amino groups of amino acids and proteins react non-enzymatically and irreversibly with reducing sugars to produce advanced glycation endproducts (hereinafter abbreviated as AGEs). Methylguanidine is known as a typical inhibitor.

In recent years, it has been found that protein glycation occurs in vivo, and that protein glycation causes various aging phenomena such as diabetes, arteriosclerosis, skin sagging, wrinkles, and dullness associated with aging. rice field. Although a drug having an anti-glycation effect has been developed by inhibiting the production of AGEs (Non-Patent Document 1), it is known to have side effects.

Am J Nephrol. 2004; 24, 32-40.

An object of the present invention is to provide a composition that is safe and can be used on a daily basis and has excellent anti-glycation activity.

The present inventors have found that a combination of specific materials has a superior anti-glycation effect compared to using them alone, and completed the present invention.

That is, the present invention is as follows.
[1] A composition containing at least two selected from polyamine or its salt, chrysanthemum, safflower, rose, pomegranate, barley and mugwort.
[2] A composition containing polyamine or a salt thereof and at least one selected from chrysanthemum, safflower, barley and mugwort.
[3] The composition according to [2], which contains polyamine or a salt thereof and at least one selected from chrysanthemum, safflower, barley and mugwort at a ratio of 1:10 to 5000.
[4] A composition containing chrysanthemum and at least one selected from safflower, rose and pomegranate.
[5] The composition according to [4], containing chrysanthemum and at least one selected from safflower, rose and pomegranate at a ratio of 1:0.01 to 100.
[6] A composition containing polyamine or its salt, chrysanthemum and safflower.
[7] The composition according to any one of [1] to [6], which is an anti-glycation composition.
[8] The composition according to any one of [1] to [6], which is a cosmetic composition.
[9] The composition according to [1] to [8], which is an oral composition.
[10] The composition according to [1] to [8], which is a cosmetic composition.

The composition of the present invention has a remarkable anti-glycation effect on proteins and the like by combining specific ingredients. In addition, suppressing the production of AGEs by preventing glycation of proteins etc. leads to suppression of activation of the final glycation product receptor (Receptor for AGE; RAGE), which causes various symptoms caused by glycation. The composition of the invention can be an excellent anti-glycation composition or cosmetic composition.

FIG. 2 is a diagram showing the saccharification reaction inhibition rate in Examples 1 and 2 and Comparative Examples 1 and 3. FIG. FIG. 3 is a graph showing the saccharification reaction inhibition rate of Examples 3-4 and Comparative Examples 4-6. FIG. 10 is a graph showing the saccharification reaction inhibition rates of Example 5 and Comparative Examples 7 and 8. FIG. FIG. 10 is a graph showing the saccharification reaction inhibition rates of Examples 6 and 7 and Comparative Examples 9-11. FIG. 10 is a diagram showing the saccharification reaction inhibition rate of Example 8 and Comparative Examples 12 and 13. FIG. FIG. 10 is a diagram showing the saccharification reaction inhibition rates of Example 9 and Comparative Examples 14 and 15. FIG. FIG. 10 is a graph showing the saccharification reaction inhibition rates of Example 10 and Comparative Examples 16-17.

The composition of the present invention is characterized by containing at least two selected from polyamines or salts thereof, chrysanthemum, safflower, pomegranate, rose, barley, and mugwort. In particular, it is preferable to contain a combination of polyamine or a salt thereof and at least one selected from chrysanthemum, safflower, barley and mugwort, or a combination of chrysanthemum and at least one selected from safflower, rose and pomegranate. or a salt thereof, chrysanthemum and safflower are more preferable from the viewpoint of exhibiting excellent anti-glycation action.

The composition of the present invention can be expected to have an excellent AGE production inhibitory action, that is, an excellent saccharification reaction inhibitory action. In addition, the composition of the present invention can be expected to prevent and/or improve various symptoms caused by glycation, such as aging and symptoms that may affect beauty. Therefore, the composition of the present invention can be used as an anti-glycation composition or cosmetic composition.

Materials used in the present invention are described in detail below.

(polyamine)
Polyamine in the present invention means an aliphatic carbohydrate having two or more primary amino groups, and includes, for example, diamine, triamine, tetraamine, pentaamine, hexaamine, etc. More specifically, the diamine is ethylenediamine. , putrescine, cadaverine, hexamethylenediamine, ethambutol, phenylenediamine, as a triamine, pentamethyldiethylenetriamine, trimethylenediamine, spermidine, caldin, homospermidine, aminopropylcadaverine, as a tetraamine, spermine, thermospermine, theremine, aminopentylnorspermidine , aminopropyl homospermine, homospermine, canavalmine, pentaamine as caldopentamine, homocaldopentamine, aminopropyl canavalmine, bis(aminopropyl) homospermine, bis(aminopropyl) norspermine, aminobutyl canabalmine , aminopropyl homospermine, homopentamine, and hexamine include cardohexamine, homocaldohexamine, cellmohexamine, homocermohexamine, and the like. The composition of the present invention may contain a plurality of such polyamines. In the composition of the present invention, one or more of spermidine, spermine, and putrescine is used because it exists in the human body, so it has high utilization efficiency, and because it exhibits a high anti-glycation effect when used in combination with other specific materials. Among them, it is more preferable to contain spermine, which has the highest physiological activity due to the large number of amino groups. Moreover, the polyamine of the present invention may be in the form of a physiologically available salt.

Polyamines are present in all organisms and can be isolated from sources such as tissues of various organisms. Specifically, plant materials such as rice, soybeans, pepper, oranges, bananas, and apples, or their processed products, fish meat and organs such as salmon, and animal materials such as meat and organs of animals such as beef and pork, or their products. Processed products, fungal materials such as mushrooms and yeast, or processed products thereof can be used. In the present invention, polyamines obtained by chemical synthesis or biochemical synthesis using enzymes or microorganisms may be used.

Processed forms of raw materials containing polyamine include dried matter, pulverized matter or dried powder thereof (hereinafter also referred to as "pulverized powder"), squeezed matter or dried powder thereof (hereinafter also referred to as "pulverized powder"), and extraction. products or dry powders thereof (hereinafter also referred to as “extracted powder”), granules, pastes, and the like. Solvents used for extraction include organic solvents such as water, methanol, ethanol, isopropanol, acetone, 1,3-butylene glycol, ethylene glycol, propylene glycol, glycerin, ethyl acetate, diethyl ether, hexane, acetic acid, citric acid, or these. or an acidic aqueous solution such as an aqueous solution of or a mixed solvent thereof. The temperature of the extraction solvent can be appropriately set between room temperature and the boiling point or below depending on the solvent used.

As the polyamine-containing raw material, rice, soybeans, mushrooms or yeast are preferably used, rice is more preferable, and rice germ is particularly preferable. As the processing form of the raw material containing polyamine, it is preferable to use pulverized product or pulverized powder, squeezed product or squeezed powder, extract or extracted powder, more preferably extract or extracted powder, It is more preferable to use the extract or extraction powder of an acidic aqueous solution, and it is particularly preferable to use the extract or extraction powder of an aqueous citric acid solution. In the present invention, it is most preferable to use a rice germ citric acid aqueous solution extract or a citric acid aqueous solution extract powder, since excellent anti-glycation action is exhibited when used in combination with other specific materials. In addition, the content of polyamines contained in the citric acid aqueous solution extract of rice germ is preferably 0.001% or more, more preferably 0.005%, from the viewpoint of having an excellent anti-glycation effect when used in combination with other specific materials. 0.01% or more is particularly preferable, and 0.05% or more is particularly preferable. The polyamine content can be analyzed by high performance liquid chromatography (HPLC).

(chrysanthemum)
The chrysanthemum in the present invention is a plant belonging to the genus Chrysanthemum of the Asteraceae family, and its scientific name is Chrysanthemum morifolium Ramat. Chrysanthemum grows wild in Japan and is easily available, and its flower part has been used for medicinal purposes since ancient times in China. In Japan, it is drunk as tea and alcohol, and is used as food in cooking, and is said to be effective for dizziness, headaches, eye fatigue, etc. Specific varieties include purple chrysanthemum known as 'Enmeiraku', yellow chrysanthemum known as 'Abomiya', and 'Kogiku'. Among these, it is preferable to use purple chrysanthemum because it exhibits an excellent anti-glycation effect when used in combination with other specific materials.

Chrysanthemum stems, leaves, fruits, pericarp, seeds, seed coats, roots, flowers and the like can be used as they are, but flowers are preferably used in the present invention. In addition, in the present invention, various processed products of chrysanthemum can be used, and as the processing form, the same processing form as the raw material containing the polyamine can be selected. Among them, pulverized material or pulverized powder, squeezed material or squeezed powder, extract or extracted powder are preferable, and pulverized material or pulverized powder is particularly preferable. In the present invention, it is most preferable to use pulverized flowers or pulverized powder, since excellent anti-glycation action is exhibited when used in combination with other specific ingredients.

(barley)
Barley used in the present invention is a plant belonging to the Gramineae family, and its scientific name is Hordeum vulgare. Barley that can be used includes two-rowed barley, six-rowed barley, bare barley, and the like, and these can be used singly or in combination of two or more.

The parts of barley used in the present invention include flowers, seeds, fruits, leaves, stems and roots. It is preferable to use one or more species (hereinafter sometimes referred to as stems and leaves). The foliage is preferably harvested before maturity, that is, from the stage of tillering to before heading.

In the present invention, various processed products of barley can be used, and the processed form can be selected from the same processed form as the raw material containing the above-mentioned polyamine. Among them, pulverized material or pulverized powder, squeezed material or squeezed powder, extract or extracted powder are preferable, and pulverized material or pulverized powder is particularly preferable. In the present invention, it is most preferable to use pulverized foliage or pulverized stems and leaves because they show excellent anti-glycation action when used in combination with other specific ingredients.

(Mugwort)
In the present invention, mugwort is a perennial plant belonging to the genus Artemisia of the Asteraceae family, and its scientific name is Artemisia princeps. The parts of mugwort used in the present invention include flowers, seeds, fruits, leaves, stems, and roots, but it is preferable to use stems and leaves from the viewpoint of exhibiting an excellent anti-glycation effect when used in combination with other specific ingredients.

In the present invention, various processed products of mugwort can be used, and the processed form can be selected from the same processed form as the raw material containing the above-mentioned polyamine. Among them, pulverized material or pulverized powder, squeezed material or squeezed powder, extract or extracted powder are preferable, and pulverized material or pulverized powder is particularly preferable. In the present invention, it is most preferable to use pulverized foliage or pulverized stems and leaves because they show excellent anti-glycation action when used in combination with other specific ingredients.

(pomegranate)
In the present invention, the pomegranate belongs to the genus Pomegranate of the family Lythraceae, and its scientific name is Punica granatum. The parts of pomegranate used in the present invention include flowers, seeds, fruits, leaves, stems and roots, but it is preferable to use flowers because they show excellent anti-glycation action when used in combination with other specific ingredients.

In the present invention, various processed products of pomegranate can be used, and the processed form can be selected from the same processed form as the raw material containing the above-mentioned polyamine. Among them, pulverized or pulverized powder, squeezed or squeezed powder, extract or extracted powder are preferred, extract or extracted powder is more preferred, and water-containing ethanol extract or extracted powder is particularly preferred. In the present invention, it is most preferable to use a water-containing ethanol extract or a water-containing ethanol extract powder of flowers, because an excellent anti-glycation effect is exhibited when used in combination with other specific ingredients.

(rose)
In the present invention, a rose (rose) is a plant belonging to the genus Rosaceae of the family Rosaceae. The parts of roses used in the present invention include flowers, seeds, fruits, leaves, stems, and roots, but it is preferable to use flowers because they show an excellent anti-glycation effect when used in combination with other specific ingredients.

In the present invention, various raw materials can be used, and the same processing forms as those for the polyamine-containing raw material can be selected as the processing form. Among them, a pulverized product or pulverized powder, a squeezed product or squeezed powder, an extract or extraction powder is preferable, an extract or extraction powder is more preferable, and a water extract or extraction powder is particularly preferable. In the present invention, it is most preferable to use an aqueous flower extract or an aqueous extract powder, since an excellent anti-glycation effect is exhibited when used in combination with other specific ingredients.

(Safflower)
In the present invention, safflower is an annual or biennial plant belonging to the genus Safflower of the Asteraceae family, and its scientific name is Carthamus tinctorius. The parts of roses used in the present invention include flowers, seeds, fruits, leaves, stems, and roots, but it is preferable to use flowers because they show an excellent anti-glycation effect when used in combination with other specific ingredients.

In the present invention, various processed products of safflower can be used, and as the processed form, the same processed form as the raw material containing the above polyamine can be selected. Among them, a pulverized product or pulverized powder, a squeezed product or squeezed powder, an extract or extraction powder is preferable, an extract or extraction powder is more preferable, and a water extract or extraction powder is particularly preferable. In the present invention, it is most preferable to use the water extract or water extract powder of flowers, since they show excellent anti-glycation action when used in combination with other specific ingredients.

The composition of the present invention is, for example, a drug, a cosmetic (including quasi-drugs), a food for specified health use, a food with nutrient function claims, a food with functional claims, etc. It can be used as so-called health foods such as foods, general foods, food additives, feeds, and the like.

Since the composition of the present invention has an antiglycation effect, it is useful for various symptoms caused by glycation, such as aging, alopecia/hair loss, diabetes, arteriosclerosis, osteoporosis, bone loss, infertility, Alzheimer's disease, In addition to symptoms such as senile plaques in the brain, sexual dysfunction, and decreased eye focus adjustment muscle function, skin wrinkles, skin spots, sagging skin, dry skin, decreased skin elasticity, loss of skin transparency, It can be used for the prevention and/or improvement of symptoms that may affect beauty, such as yellowish dullness in the whites of the eyes and opacification of the black of the eyes. Therefore, the composition of the present invention can be used as an anti-glycation composition or cosmetic composition. Anti-glycation compositions and cosmetic compositions are distinguished from other products as products in that they are used for anti-glycation and the effect or efficacy on various symptoms caused by anti-glycation including the above-mentioned symptoms that can affect beauty. There is no particular limitation as long as it can be used. For example, the main body, package, instruction manual, or promotional material of the product according to the present invention indicates that it has anti-glycation or beauty-related functions. In addition, the scope of the present invention includes those labeled as having other functions, or those that substantially have an anti-glycation effect or cosmetic effect even if they are not labeled as to their function. The anti-glycation composition and cosmetic composition of the present invention are those in which the combination of ingredients (polyamine, safflower, chrysanthemum, etc.) of the present invention is indicated as an anti-glycation or cosmetic active ingredient on the packaging of the product. Not limited. For example, the active ingredients may not be specified, or only some of the ingredients may be indicated as active ingredients.

Specifically, the anti-glycation composition and beauty composition of the present invention include pharmaceuticals, so-called health foods, and cosmetics (including quasi-drugs). "Prevent aging", "anti-aging", "anti-aging", "anti-aging", "prevent glycation", "prevent increase in AGEs", "suppress activation of RAGE", "expression of RAGE" "Reduces volume", "Prevents burns in the body", "For a clearer day", "For those concerned about dull skin", "For those concerned about yellowish dullness", "Reduces sagging skin" For those who are concerned about wrinkles, For those who are concerned about blemishes, For dry skin, For beauty, For skin, For beauty An example that displays "Support" or the like can be exemplified.

The composition of the present invention can be used topically or orally. External use is not particularly limited as long as it is used by applying or sticking to the skin, scalp, etc., and its forms include ointments, creams, gels, lotions, milky lotions, packs, poultices. Forms such as external preparations for skin such as and injections can be exemplified.

For oral use, for example, tablets, capsules, powders, granules, liquids, granules, rods, plates, blocks, solids, rounds, pastes, creams, caplets, gels, and chewables. shape, stick shape, and the like. Among these, tablet, capsule, powder, granule and liquid forms are preferred, and tablet, powder and granule form are particularly preferred. Specifically, supplements, packaged beverages filled in PET bottles, cans, bottles, etc., instant beverages for drinking by dissolving in water (hot water), milk, fruit juice, green juice, etc., and food additives can be exemplified. In particular, supplements and instant beverages are preferable because they are easy to drink with meals and can enhance palatability.

The composition of one embodiment of the present invention can be a packaged composition that is packed and sealed in a container. Although the container is not particularly limited, for example, metal such as aluminum, paper, plastic such as PET and PTP, single-layer or laminated film bag, retort pouch, vacuum pack, aluminum container, plastic container, bottle, can, etc. packaging container. In order to avoid deterioration over time, the composition of one embodiment of the present invention is preferably sterilized by pressurization and/or heating after being sealed in a container.

The method of using the composition of one embodiment of the present invention is not particularly limited. can do. The composition of one embodiment of the present invention may be mixed with other solids or liquids and orally ingested according to the preferences of the ingestor. When the composition of one embodiment of the present invention is made into an orally disintegrating dosage form, it can be orally ingested without water.

As for the content of the specific material in the composition of the present invention, it may be appropriately contained within the range in which the effect is exhibited.

In general, when the composition of the present invention is a tablet, chewable supplement or drug, the total amount of the material of the present invention is 0.1 to 80% of the total dry mass. preferably 0.5 to 60%, more preferably 1 to 50%.

When the composition of the present invention is a packaged beverage, the total content of the material of the present invention is preferably 0.0001 to 5%, preferably 0.0005 to 3%. More preferably, it is contained in an amount of 0.001 to 1%.

When the composition of the present invention is an instant beverage, the total amount of the material of the present invention in terms of dry mass is preferably 0.01 to 50%, preferably 0.05 to 30%. It is more preferable that the content is 0.1 to 20%.

Further, when the composition of the present invention is used for cosmetics, the total amount of the material of the present invention in terms of dry mass is preferably 0.0001 to 75% of the total, preferably 0.0005 to 50%. It is more preferably contained, more preferably 0.001 to 25%.

The intake of the composition of the present invention is not particularly limited, but from the viewpoint of exhibiting the effects of the present invention more remarkably, the total amount of the materials of the present invention per day for adults is 0.001 mg/day or more. more preferably 0.01 mg/day or more, even more preferably 0.1 mg/day or more. The upper limit is, for example, 100000 mg/day, preferably 50000 mg/day. The oral composition of the present invention can be contained in one container or divided into a plurality of containers, for example 2 to 3, so that the daily intake is equal to the above-mentioned intake for one day.

The blending ratio of each material in the composition of the present invention is not particularly limited, but for example, the blending mass ratio of polyamine or its salt and other materials is in the range of 1:1 to 50000 in terms of dry mass. is preferably in the range of 1:3 to 30,000, more preferably in the range of 1:5 to 10,000, and particularly preferably in the range of 1:10 to 5,000.

In addition, the blending mass ratio of chrysanthemum and other materials is preferably in the range of 1:100 to 50000:1, more preferably in the range of 1:0.0001 to 10000 in terms of dry mass. It is preferably in the range of 1:0.001 to 1000, and particularly preferably in the range of 1:0.01 to 100.

The blending mass ratio of polyamine or its salt, chrysanthemum and safflower is preferably in the range of 1:1 to 30000:1 to 30000, more preferably 1:3 to 10000:3 to 10000 in terms of dry mass. is more preferably in the range of 1:5 to 7500:5 to 7500, and particularly preferably in the range of 1:10 to 5000:10 to 5000.

The composition of the present invention can be produced by a known method by adding other components other than the components of the present invention, if necessary. Other ingredients other than the ingredients of the present invention include, for example, water-soluble vitamins (vitamin B1, B2, B3, B5, B6, B12, B13, B15, B17, biotin, choline, folic acid, inositol, PABA, vitamin C, vitamin P), oil-soluble vitamins (vitamins A, D, E, K); minerals such as calcium, magnesium, phosphorus, and iron; sulfur-containing compounds contained in taurine, garlic, etc.; hesperidin, quercetin, etc. proteins such as collagen; peptides; amino acids; animal oils and fats; vegetable oils and fats;

EXAMPLES The present invention will be specifically described below based on examples.

[Evaluation of anti-glycation effect of composition]
The following were used as test substances.
- As a polyamine, citric acid aqueous solution extraction powder of rice germ (commercial product; containing 0.2% or more of polyamine) was used.
・As the chrysanthemum, crushed purple chrysanthemum flower powder (commercially available) was used.
- A water extract of safflower flowers (commercially available) was used as safflower.
・As the rose, water-extracted powder of rose flower (commercial product) was used.
・As the pomegranate, water-containing ethanol extract powder of pomegranate flowers (commercial product) was used.
- As barley, pulverized powder of young barley leaves (manufactured by Toyo Shinyaku Co., Ltd.) was used.
・As mugwort, pulverized mugwort powder (manufactured by Toyo Shinyaku Co., Ltd.) was used.

Phosphate buffer powder (1/15 mol/L pH 7.2) was dissolved in distilled water to prepare 67 mM phosphate buffer (hereinafter abbreviated as 67 mM PB). In addition, D(+) glucose was dissolved in 67 mM B to prepare a 200 mg/mL glucose solution, and albumin (cohn fraction V derived from bovine serum, pH 7.0, for biochemistry) (hereinafter abbreviated as BSA) was added. 40 mg./mL BSA was prepared by dissolving in 67 mM BSA.

Predetermined amounts of the test substances of Comparative Examples 1 to 17 and Examples 1 to 10 were each vortexed in 67 mM B for 1 hour and centrifuged (room temperature, 10,000 rpm, 5 minutes). and A test substance solution, a glucose solution, a BSA solution, and PB were mixed in the amounts shown in Table 1 in a 1.5 mL tube to prepare a test substance-containing solution (test solution) used in the test. Similarly, a control containing no test substance was prepared. Tables 2 to 5 show the concentrations of the test solutions of comparative examples and examples relating to combinations of polyamine and chrysanthemum, safflower, barley or mugwort, and comparative examples and examples relating to combinations of chrysanthemum and safflower, rose or pomegranate. are shown in Tables 6-8. The unit of numerical values in Tables 2-8 is mg/mL.

Each solution of the test solution or control prepared in a 1.5 mL tube was mixed by inversion and then incubated at 60° C. for 48 hours. 30 μL of each solution after incubation was transferred to a 96-well plate and diluted with 270 μL of pure water. The fluorescence intensity at 440 nm when the diluted solution was excited at 370 nm was measured with a spectrofluorophotometer, and the AGEs formation inhibition rate (%) was calculated by the following formula.

AGEs production inhibition rate (%)
= (1 - [(Sample _test - Sample _blank )/ (Control _test - Control _blank ) ]) x 100
(In the formula, Sample _test : Fluorescence intensity of the test solution (test)
Sample _blank : Fluorescence intensity of test solution (blank)
Control _test : Fluorescence intensity of control (test)
Control _blank : Fluorescence intensity of control (blank)
The results are shown in Figures 1-7.

As is clear from FIGS. 1 to 4, in Examples 1 to 6, in which polyamine or its salt was combined with chrysanthemum, safflower, barley, or mugwort, a dramatic effect that cannot be obtained by adding the effects of each material alone. was accepted. 5 to 7, in Examples 8 to 10 in which chrysanthemum and safflower, rose, or pomegranate were combined, dramatic effects were observed that could not be obtained by adding the effects of each material alone. rice field. Therefore, it can be seen that the composition of the present invention has an excellent anti-glycation effect. Furthermore, from FIG. 4, in Example 7, in which the three materials of polyamine or its salt, chrysanthemum and safflower were combined, a dramatic effect that could not be obtained by adding the effects of each material alone was observed. It was remarkable even when compared with Examples 1, 2, 6 and 10, which were combinations of two selected from polyamines or salts thereof, chrysanthemum and safflower. Therefore, it can be seen that the composition containing three of polyamine or its salt, chrysanthemum and safflower has particularly excellent anti-glycation action compared to the combination of two selected from polyamine or its salt, chrysanthemum and safflower. .

[Production of the composition of the present invention]
[Example 11] (Production of tablets)
Tablets (300 mg) were produced from the following materials. Take 2 of the resulting tablets per day. The produced tablet can be taken with water once or twice a day to obtain an excellent anti-glycation effect. The tablets obtained contained 0.01% of polyamine or its salt by HPLC analysis, and the percentage of spermine in the polyamine or its salt was 50%.

Rice germ citric acid aqueous solution extraction powder 2%
Purple chrysanthemum flower pulverized powder 10%
Water extract powder of safflower flower 10%
Hot water extraction powder of rose flower 10%
Water-containing ethanol extract powder of pomegranate flower 10%
2% vitamin C
1% gum arabic
Calcium stearate 1%
Silicon dioxide 1%
maltose rest

[Example 12] (Production of tablets)
A tablet (350 mg) was produced from the following materials. The resulting tablets are taken 6 per day. The manufactured tablet can be taken with water once or divided into 2 or 3 times a day to obtain an excellent anti-glycation effect.

Rice germ citric acid aqueous solution extraction powder 5%
Purple chrysanthemum flower pulverized powder 10%
10% crushed powder of barley stems and leaves
Mugwort foliage pulverized powder 10%
Lactic acid bacteria 5%
Calcium stearate 1%
Reduced maltose Remainder

[Example 13] (Production of capsules)
The following mixture was encapsulated in hard capsules to produce capsules (300 mg). Five hard capsules thus obtained are ingested per day. The produced capsules can be taken with water once or divided into 2 to 4 times a day to obtain an excellent anti-glycation effect.

Rice germ acetic acid extract powder 30%
5% crushed safflower flower powder
Squeezed barley stem and leaves 20%
Mugwort foliage pulverized powder 15%
Lactic acid bacteria 5%
Vitamin C 1%
folic acid 1%
Silicon dioxide 2%
Cellulose remainder

[Example 14] (Production of granules)
Granules (3000 mg) were produced by a conventional method by mixing the following ingredients. The resulting granules provide excellent anti-glycation action when taken with water. Moreover, the obtained granules contained 0.01% of polyamine or its salt.

Rice germ acetic acid extraction powder 3%
Water extract powder of purple chrysanthemum flower 5%
Pomegranate fruit juice powder 10%
Hot water extraction powder of rose flower 5%
2% juice powder of mugwort stems and leaves
Aspartame 0.1%
Thiamine hydrochloride 0.3%
Riboflavin 0.3%
Vitamin B6 0.2%
Cyanocobalamin 0.2%
Perfume 0.2%
Reduced palatinose 7%
Calcium stearate 3%
hydroxypropyl cellulose balance

[Example 15] (Production of chewable tablet)
Chewable tablets (1000 mg per tablet) were manufactured from the following materials. The resulting chewable tablets are taken 6 per day. The produced chewable tablet can be taken with water once or divided into 2 or 3 times a day to obtain an excellent anti-glycation effect.

Soybean germ citric acid aqueous solution extraction powder 5%
Hot water extract of purple chrysanthemum flower 3%
Hot water extract of rose flower 10%
Water extract powder of safflower flower 5%
Squeezed barley stalks and leaves 5%
Sucralose 0.1%
Aspartame 0.05%
Vitamin B1 0.01%
Vitamin B2 0.01%
Vitamin B6 0.01%
Perfume 0.01%
Calcium stearate 1%
Silicon dioxide 2%
Hydroxypropyl cellulose 1%
Cellulose 30%
Reduced Palatinose Balance

[Example 16] (Production of cosmetic cream)
A cosmetic cream was produced from the following materials. The resulting cosmetic cream exhibits an excellent anti-glycation action when applied.

Rice germ citric acid aqueous solution extraction powder 0.1%
0.1% crushed purple chrysanthemum flower powder
Water extract powder of safflower flower 0.1%
Water-containing 1,3-butylene glycol extract powder of mugwort stems and leaves 0.1%
Squalane 15%
Octyldodecyl myristate 4%
Hydrogenated soybean phospholipid 0.2%
Butyl alcohol 2%
Hydrogenated oil 2%
Stearic acid 2%
Lipophilic glyceryl monostearate 2%
Polyglyceryl monostearate 0.5%
Behenyl alcohol 0.8%
Polyglyceryl monomyristate 0.7%
Bleached beeswax 0.3%
d-δ-tocopherol 0.1%
Methylparaben 0.3%
C10-30 alkyl-modified carboxyvinyl polymer 0.2%
Carboxy vinyl polymer 0.1%
1,3-butanediol 18%
Sodium hydroxide 0.1%
Remainder of purified water

Since the composition of the present invention has an anti-glycation effect and the like, the industrial utility of the present invention is high.

Claims (2)

A composition containing rice germ citric acid aqueous solution extract and chrysanthemum (however, yeast extract, purple chrysanthemum flower extract, fish collagen, soybean peptide, L-ornithine, hyaluronic acid, ceramide, biotin, proteoglycan, lotus germ extract and wheat (excluding beauty drinks containing peptides). 2. The composition of claim 1, further comprising safflower.

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