JP7337481B2 - oral composition - Google Patents

Description

The present invention relates to oral compositions, particularly liquid oral compositions and the like.

Liquid oral compositions, such as mouthwashes, usually contain more than 5% by weight of ethanol for the purpose of imparting a pleasant feel to the composition and avoiding the problem of low-temperature solidification. However, it is desired not to contain ethanol from the viewpoint of safety in case of accidental ingestion by infants, stability of active ingredients such as enzymes, etc. (for example, Patent Document 1).

In addition, it is known that the adhesion of dental plaque (plaque) is a cause of dental caries and periodontitis, and that its removal and adhesion prevention, that is, plaque control, are important in oral hygiene. Conventionally, plaque control is generally performed by brushing, i.e., mechanical plaque removal with a toothbrush, and chemical plaque control, which cleans oral bacteria by using surfactants. The method. Sodium lauryl sulfate is often used for chemical plaque control.

However, when sodium lauryl sulfate is added to a liquid oral composition, it tends to precipitate during low-temperature storage. It has been difficult to incorporate an effective amount of sodium lauryl sulfate in products involving liquid oral formulations that do not contain any active ingredients.

JP-A-2000-044447

An object of the present invention is to provide a liquid composition for oral cavity containing substantially no ethanol in which precipitation of sodium lauryl sulfate is suppressed.

The present inventors found the possibility of suppressing the precipitation of sodium lauryl sulfate in liquid oral compositions substantially free of ethanol by further blending a sulfosuccinic acid surfactant, and made further improvements. As a result, the present invention has been completed.

The invention includes, for example, the subject matter described in the following sections.
Section 1.
(A) 0.1 to 0.4% by mass of sodium lauryl sulfate,
(B) 0.01 to 1% by mass of a sulfosuccinic acid-based surfactant, and (C) 0.1 to 1% by mass of polyoxyethylene hydrogenated castor oil,
including
A liquid oral composition substantially free of ethanol.
Section 2.
Item 2. The liquid oral composition according to Item 1, containing 0.03 to 0.6% by mass of component (B).
Item 3.
Item 3. The liquid oral composition according to item 1 or 2, comprising 0.2 to 0.8% by mass of component (C).
Section 4.
Items 1 to 3 wherein the component (B) is at least one selected from the group consisting of polyoxyethylene alkyl(12-14) disodium sulfosuccinate and alkyl (C12-14) disodium sulfosuccinate. The liquid oral composition according to any one of .
Item 5.
Item 5. The liquid oral composition according to any one of Items 1 to 4, further comprising at least one flavoring agent selected from the group consisting of anethole, menthol, spearmint oil, mint oil, and peppermint oil.
Item 6.
Item 6. The liquid oral composition according to any one of Items 1 to 5, further comprising 5 to 20% by mass of glycerin.
Item 7.
A method for producing a substantially ethanol-free oral composition with inhibited precipitation of sodium lauryl sulfate, comprising the step of blending a sulfosuccinic acid-based surfactant and a polyoxyethylene hydrogenated castor oil.
Item 8.
A method for inhibiting precipitation of sodium lauryl sulfate in a substantially ethanol-free oral composition comprising the step of incorporating a sulfosuccinic surfactant and a polyoxyethylene hydrogenated castor oil.
Item 9.
(A) 0.1 to 0.4% by mass of sodium lauryl sulfate,
(C) 0.1 to 1% by mass of polyoxyethylene hydrogenated castor oil, and 0.01 to 1% by mass of at least one selected from the group consisting of menthol and spearmint oil
including
A liquid oral composition substantially free of ethanol.

INDUSTRIAL APPLICABILITY According to the present invention, precipitation of sodium lauryl sulfate can be suppressed even in a liquid oral composition that does not substantially contain ethanol.

Each embodiment of the present invention will be described in further detail below.

The liquid oral composition included in the present invention (sometimes referred to as "the liquid oral composition of the present invention") does not substantially contain ethanol. “Substantially free” means that ethanol is not blended in the manufacturing process. In other words, when blending raw ingredients in the process of manufacturing a liquid oral composition, if a small amount of ethanol is mixed with the other ingredients, the liquid oral composition inevitably contains ethanol. are not excluded from the present invention. The ethanol content in the liquid oral composition of the present invention is preferably 1% by mass or less, more preferably 0.9, 0.8, 0.7, 0.6, 0.5, 0.4, 0.9% by mass or less. 3, 0.2, or 0.1% by mass or less, more preferably 0.09, 0.08, 0.07, 0.06, 0.05, 0.04, 0.03, 0.02, or It is 0.01% by mass or less.

The liquid oral composition of the present invention contains (A) 0.1 to 0.4% by mass of sodium lauryl sulfate, (B) 0.01 to 1% by mass of a sulfosuccinic acid surfactant, and (C) a poly 0.1 to 1% by mass of oxyethylene hydrogenated castor oil. In this specification, sodium lauryl sulfate is sometimes referred to as the (A) component, the sulfosuccinic acid-based surfactant as the (B) component, and the polyoxyethylene hydrogenated castor oil as the (C) component. These components may exist as ions in the liquid oral composition, but in the present specification, "the liquid oral composition contains these components" means that they exist as ions. also includes

Sodium lauryl sulfate (component (A)) is preferably contained in an amount of 0.15% by mass or more. The content is preferably 0.35% by mass or less, more preferably 0.3% by mass or less, and even more preferably 0.25% by mass or less.

As the sulfosuccinic acid-based surfactant (component (B)), a sulfosuccinic acid-based active agent having an average number of added moles of ethylene oxide of 0 to 7 (especially 0, 1, 2, 3, 4, 5, 6, or 7) agents are preferred.

Among them, the alkyl group is a saturated or unsaturated alkyl group having 8 to 18 carbon atoms (preferably 8, 10, 12, 14, 16, or 18), and the average number of added moles of ethylene oxide is 0 to 7. At least one sulfosuccinic acid-based surfactant selected from the group consisting of a certain monoalkylsulfosuccinic acid/polyoxyethylene monoalkylsulfosuccinic acid and salts thereof is preferred. Among them, a sulfosuccinic acid-based surfactant having an alkyl group having 12 to 16 carbon atoms and an average number of added moles of ethylene oxide of 0 to 3 is more preferable. The "/" in "monoalkylsulfosuccinic acid/polyoxyethylene monoalkylsulfosuccinic acid" indicates monoalkylsulfosuccinic acid when the average number of added moles of ethylene oxide is 0, and the average number of added moles of ethylene oxide is the same. Other than (especially 1 to 7) indicates that it is a polyoxyethylene monoalkyl ether sulfosuccinic acid.

In particular, as the component (B), polyoxyethylene alkyl (C 12-14) disodium sulfosuccinate (especially polyoxyethylene lauryl disodium sulfosuccinate), alkyl (C 12-14) disodium sulfosuccinate ( Among them, disodium laurylsulfosuccinate) is preferred. Disodium polyoxyethylene lauryl sulfosuccinate is also called disodium laureth sulfosuccinate, and the average number of added moles of ethylene oxide is preferably 0 to 7.

More specifically, for example, disodium monolauryl sulfosuccinate, polyoxyethylene (1) monoalkyl (12 to 14 carbon atoms) disodium sulfosuccinate, polyoxyethylene (2) monoalkyl (12 to 14 carbon atoms) Disodium sulfosuccinate, disodium polyoxyethylene (2) monolauryl sulfosuccinate, polyoxyethylene (2) monoalkyl (C12-14) 2-triethanolamine sulfosuccinate, polyoxyethylene (3) monoalkyl (carbon Numbers 12-14) disodium sulfosuccinate, polyoxyethylene (3) disodium monolauryl sulfosuccinate, polyoxyethylene (3) magnesium monolauryl sulfosuccinate, polyoxyethylene (3) monococonut fatty acid (C8-18) ) disodium sulfosuccinate, polyoxyethylene (5) monoalkyl (12-14 carbon atoms) disodium sulfosuccinate, polyoxyethylene (5) monococonut fatty acid (8-18 carbon atoms) disodium sulfosuccinate, polyoxyethylene (5) monolauryl sulfosuccinic acid diethanolamide, polyoxyethylene (5) magnesium lauryl sulfosuccinate, polyoxyethylene (5) monococonut oil fatty acid (C8-18) disodium sulfosuccinate, polyoxyethylene sulfosuccinate (5) Disodium lauroylethanolamide, disodium polyoxyethylene (7) monoalkyl (12 to 14 carbon atoms) sulfosuccinate, magnesium polyoxyethylene (7) monolauryl sulfosuccinate, etc. Among these, monolauryl sulfosuccinate 2 Sodium, polyoxyethylene (1) monoalkyl (C12-14) disodium sulfosuccinate, polyoxyethylene (2) monoalkyl (C12-14) disodium sulfosuccinate, polyoxyethylene (2) monolauryl Disodium sulfosuccinate, polyoxyethylene (3) monoalkyl (12 to 14 carbon atoms) disodium sulfosuccinate, disodium polyoxyethylene (3) monolauryl sulfosuccinate, polyoxyethylene (5) monoalkyl (12 carbon atoms) 14) disodium sulfosuccinate, polyoxyethylene (7) monoalkyl (12 to 14 carbon atoms) disodium sulfosuccinate is more preferable, disodium lauryl sulfosuccinate, polyoxyethylene (2) monoalkyl (12 to 14 carbon atoms) 14) Disodium sulfosuccinate and polyoxyethylene (3) monoalkyl (C12-14) disodium sulfosuccinate are particularly preferred.

The sulfosuccinic acid-based surfactants can be used as the component (B) singly or in combination of two or more. Especially when magnesium salt is used, it is preferable to use it together with sodium salt. Regarding the alkyl group distribution of coconut oil fatty acid, one having 8 to 18 carbon atoms can be used, but 10 to 18 carbon atoms are more preferable, and 10 to 16 carbon atoms are most preferable.

The numbers in parentheses after the above polyoxyethylene mean the average number of added moles of ethylene oxide. Polyoxyethylene is sometimes described as POE.

Component (B) is preferably contained in an amount of 0.02% by mass or more, 0.03% by mass or more, 0.04% by mass or more, or 0.05% by mass or more in the liquid oral composition of the present invention. . Also preferably, 0.9% by mass or less, 0.8% by mass or less, 0.7% by mass or less, 0.6% by mass or less, 0.5% by mass or less, 0.4% by mass or less, 0.3% by mass or less % by mass or less, 0.2% by mass or less, or 0.1% by mass or less. Any combination of these upper and lower limits is preferred.

The polyoxyethylene hydrogenated castor oil (component (C)) is not particularly limited as long as the effect of the present invention is exhibited, but the average number of added moles of ethylene oxide is preferably about 10 to 100, more preferably 20 to 80. A degree is more preferable. In particular, those having an average added mole number of ethylene oxide of about 10, 16, 20, 25, 30, 35, 40, 45, 50, 54, 55, 60, 65, or 80 are preferable. The polyoxyethylene hydrogenated castor oil can be used as the component (C) singly or in combination of two or more.

In addition, component (C) is preferably contained in the liquid oral composition of the present invention in an amount of 0.15% by mass or more, 0.2% by mass or 0.3% by mass or more. Moreover, it is preferably contained in an amount of 0.9% by mass or less, 0.8% by mass or less, 0.7% by mass or less, or 0.6% by mass or less. Any combination of these upper and lower limits is preferable.

When the component (C) is contained in the liquid oral composition of the present invention within the above content range, the effect of sustaining the effect of suppressing precipitation of sodium lauryl sulfate can be preferably exhibited.

The liquid composition for oral use of the present invention may contain components other than components (A) to (C) as long as the effects of the present invention are not impaired. Such other ingredients include, for example, ingredients known in the field of oral compositions.

For example, the liquid oral compositions of the present invention may contain glycerin. Glycerin is contained in an amount of preferably about 5-20% by mass, more preferably about 10-15% by mass.

The liquid oral compositions of the present invention may also contain flavorants (especially known flavorants used in the oral composition field).

One of the features of the present invention is that perfume can be added. The present inventors have found that when a perfume is added to a liquid oral composition containing sodium lauryl sulfate and substantially free of ethanol, sodium lauryl sulfate is more likely to precipitate depending on the type of perfume, or conversely, It was found that precipitation becomes difficult. More specifically, for example, if anethole is added to a liquid oral composition that contains sodium lauryl sulfate and does not substantially contain ethanol, sodium lauryl sulfate precipitates more easily. On the other hand, when menthol or mint oil (spearmint oil, peppermint oil, etc.) is added to the same liquid oral composition, sodium lauryl sulfate is less likely to precipitate.

However, in the development of an oral composition, if a flavor cannot be selected with a certain degree of freedom, a desired flavor cannot be imparted to the oral composition. Therefore, as a result of further investigation by the present inventors, it was found that the presence or absence of blending of perfume by further blending the above-mentioned component (B) in particular to the liquid oral composition containing sodium lauryl sulfate and substantially free of ethanol. And regardless of the type at the time of blending, it is possible to suppress the precipitation of sodium lauryl sulfate, and furthermore, when the fragrance and the component (B) are blended together, sodium lauryl sulfate is further added. It was discovered that precipitation becomes difficult.

Flavors contained in the liquid oral composition of the present invention include, for example, menthol, peppermint oil, peppermint oil, spearmint oil, α-pinene, limonene, cis-3-hexenol, anethole, citral, citronellal, citronellol, linalool, and geraniol. , eugenol, nonadienal, nonadienol, caryophyllene, γ-octalactone, γ-nonalactone, germacrene-D, viridiflorol, 1,3,5-undecatriene, piperitone, 3-octyl acetate, isoamyl isovalerate, hexanol, hexanal, α-terpineol, cis-carbyl acetate, trans-carbyl acetate, p-cymene, α-damascenone, β-damascenone, γ-damascenone, α-damascone, β-damascone, γ-damascone, δ-damascone, fenchol , cis-4-heptenal, isobutyraldehyde, isovaleraldehyde, cis-jasmone, anisaldehyde, methyl salicylate, myrtenyl acetate, 2-phenylethyl alcohol, 2-phenylethyl isobutyrate, 2-phenylethyl isovalerate, cinnamaldehyde , anise essential oil, star anise essential oil, wintergreen essential oil, tea tree essential oil, clove oil, juniper seed oil, lemon oil, orange oil, grapefruit oil, lime oil, cinnamon oil, davana oil, spruce needle oil, fennel oil, galva Numu oil, ginger oil, chamomile oil, caraway oil, rose oil, geranium oil, sage oil, thyme oil, yarrow oil, angelica root oil and the like can be used, and one or more of these can be used. can be done. Among them, mint flavor (menthol, peppermint oil, peppermint oil, spearmint oil) and anethole are preferred, and mint flavor is more preferred.

The content of perfume can be, for example, about 0.01 to 1% by mass, about 0.01 to 0.5% by mass, or about 0.02 to 0.3% by mass.

Examples of other ingredients that can be incorporated into the liquid oral composition of the present invention include sweeteners, binders, preservatives, colorants, pH adjusters, medicinal ingredients, base materials, and the like. However, there are no particular restrictions.

Examples of sweetening agents include saccharin sodium, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, perillartine, thaumatin (thaumatin), asparatylphenylalanyl methyl ester, p-methoxycinnamic aldehyde and the like. These can be used singly or in combination of two or more. Further, these can be blended, for example, in an amount of 0.01 to 1% by mass relative to the total amount of the composition.

In addition, as a binding agent, for example, cellulose derivatives such as sodium carboxymethylcellulose, carboxymethylethylcellulose salts, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, microbial polymers such as xanthan gum and gellan gum, tragacanth gum, karaya gum, arabic gum, carrageenan. , natural polymers or natural rubbers such as dextrin, synthetic polymers such as polyvinyl alcohol and polyvinylpyrrolidone, thickening silica, inorganic binders such as Veegum, O-[2-hydroxy-3-(trimethylammonio) chloride A cationic binder such as propyl]hydroxyethyl cellulose can be used singly or in combination of two or more.

As preservatives, parabens such as methylparaben, ethylparaben, propylparaben, and butylparaben, sodium benzoate, phenoxyethanol, alkyldiaminoethylglycine hydrochloride, and the like can be used alone or in combination of two or more.

As a coloring agent, legal pigments such as Blue No. 1, Yellow No. 4, Red No. 202, Green No. 3, etc., mineral pigments such as ultramarine, enhanced ultramarine, and dark blue, titanium oxide, etc. are blended alone or in combination of two or more. good too.

As a pH adjuster, citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, or chemically possible salts thereof, sodium hydroxide, or the like may be added. These may be blended singly or in combination of two or more so that the pH of the composition is in the range of 4-8, preferably 5-7. The blending amount of the pH adjuster is, for example, 0.01 to 2% by weight.

A bactericide may be added as a medicinal ingredient. For example, cationic fungicides such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, and chlorhexidine gluconate; amphoteric fungicides such as dodecyldiaminoethylglycine; nonionic fungicides such as triclosan and isopropylmethylphenol; hinokitiol and the like. In addition, it is also possible to blend a medicinal ingredient other than a bactericide. For example, vitamin E such as dl-α-tocopherol acetate, tocopherol succinate, or tocopherol nicotinate, sodium fluoride, dead nettle extract, and the like may be blended. Medicinal ingredients other than bactericides can be blended singly or in combination of two or more.

Also, as a base, for example, water, alcohols, silicone, apatite, white petrolatum, paraffin, liquid paraffin, microcrystalline wax, squalane, Plastibase (manufactured by Taisho Pharmaceutical Co., Ltd.), etc. are added singly or in combination of two or more. is also possible.

In addition, for example, cyclodextrin or the like can be blended.

Moreover, the form of the liquid oral composition of the present invention is not particularly limited as long as the effects of the present invention are not impaired. For example, it can be a dental rinse, mouthwash, mouthspray, and the like. Alternatively, the liquid oral compositions of the present invention can be prepared using methods known in the art.

The present invention also comprises the step of blending (B) a sulfosuccinic acid surfactant and (C) polyoxyethylene hydrogenated castor oil, (A) sodium lauryl sulfate precipitation is inhibited, substantially ethanol and a substantially ethanol-free oral composition comprising the steps of combining (B) a sulfosuccinic acid surfactant and (C) a polyoxyethylene hydrogenated castor oil. Also includes (A) a method for suppressing precipitation of sodium lauryl sulfate. Various conditions (for example, component types, component contents, etc.) in these methods are the same as described above.

As described above, when menthol or mint oil (spearmint oil, peppermint oil, etc.) is blended with a liquid oral composition containing sodium lauryl sulfate and substantially free of ethanol, sodium lauryl sulfate is less likely to precipitate. From the group consisting of (A) 0.1 to 0.4% by mass of sodium lauryl sulfate, (C) 0.1 to 1% by mass of polyoxyethylene hydrogenated castor oil, and menthol and spearmint oil Also included are liquid oral compositions containing 0.1 to 1% by weight of at least one selected material and substantially free of ethanol. Various conditions (for example, types of components contained in the composition, content of components, etc.) in the composition are the same as described above.

In addition, the term "comprising" includes "consisting essentially of" and "consisting of." as used herein.

The present invention will be described in more detail below, but the present invention is not limited to the following examples. "%" indicates "% by mass" unless otherwise specified.

Liquid compositions (Examples and Comparative Examples) were prepared by mixing each component according to the composition shown in Table 1 by a conventional method. The numerical value of each component in Table 1 indicates % by mass. Also, each composition of each example was prepared by adding water so that the total amount was 100% by mass. For the sulfosuccinic acid-based surfactant, the following product was purchased from Daiichi Kogyo Seiyaku Co., Ltd. and used. Neohitenol LM-20 as disodium polyoxyethylene alkyl (12-14) sulfosuccinate, Neohitenol L-30 as disodium polyoxyethylene lauryl sulfosuccinate (i.e., disodium polyoxyethylene lauryl sulfosuccinate), sulfosuccinate Neohytenol LS as disodium lauryl acid (ie disodium lauryl sulfosuccinate).

Each obtained liquid composition was stored at −5° C. for 7 days, and the presence or absence of precipitation was visually checked every day. Then, the number of days during which precipitation was not observed was counted. Compositions in which precipitation was not observed for 3 days were evaluated as ◯, and compositions in which precipitation was observed for 3 days were evaluated as x. These results are shown in Table 1 together. In addition, "-" in the result display of Table 1 indicates that only the above-mentioned ◯ and × evaluation was performed. In addition, it is possible that the composition for which no precipitation was observed for 7 days was suppressed for more than 7 days.

In addition, in the composition of Example D, the amount of sodium citrate was changed to 0.18% by mass, the amount of glycerin was changed to 13% by mass, and several other ingredients were added to change the perfume to prepare a liquid composition. At this time, the amount of polyoxyethylene (60) hydrogenated castor oil was changed to 0.2 mass %, 0.4 mass %, or 0.6 mass % to prepare 3 doses of the liquid composition. Each obtained liquid composition was stored at −5° C. for one month, and the presence or absence of precipitation was visually checked every day. Then, the number of days during which precipitation was not observed was counted. As a result, as the amount of polyoxyethylene (60) hydrogenated castor oil increased to 0.2% by mass, 0.4% by mass, and 0.6% by mass, the number of days during which precipitation was not observed was 7 days, 14 days, and 1 day. over a month, and increased.

Formulation examples according to the present invention are described below. In addition, the compounding amount value of each component is mass %.

Formulation example 1
A dental rinse was prepared according to a conventional method.
Ingredient Amount
Sodium lauryl sulfate 0.15
Polyoxyethylene (3) monoalkyl (12-14)
Disodium ether sulfosuccinate 0.6
Polyoxyethylene (60) hydrogenated castor oil 0.2
Glycerin 10.0
Cetylpyridinium chloride 0.1
Sodium citrate 0.1
Saccharin 0.05
dead nettle water extract 0.2
Perfume 0.2
Purified water Balance
Total 100.0

Formulation example 2
Mouth sprays were prepared according to standard methods.
Ingredient Amount
Sodium lauryl sulfate 0.35
Polyoxyethylene (2) monoalkyl (12-14)
Disodium ether sulfosuccinate 0.03
Polyoxyethylene (60) hydrogenated castor oil 0.8
Glycerin 5
Menthol 0.3
Saccharin 0.1
Sodium citrate 0.2
Purified water Balance
Total 100.0

Formulation example 3
A liquid dentifrice was prepared according to a conventional method.
Ingredient Amount
Sodium lauryl sulfate 0.4
Polyoxyethylene (3) monolauryl ether disodium sulfosuccinate 1
Polyoxyethylene (60) hydrogenated castor oil 1
Cetylpyridinium chloride 0.05
Sucralose 0.02
xylitol 7
Glycerin 10
Tranexamic acid 0.05
Citric acid 0.01
Trisodium citrate 0.1
Methyl paraoxybenzoate 0.1
Perfume 0.2
Purified water Balance
Total 100.0

Formulation example 4
Mouthwashes were prepared according to standard methods.
Ingredient Amount
Sodium lauryl sulfate 0.35
Polyoxyethylene (3) monoalkyl (12-14)
Disodium ether sulfosuccinate 0.02
Polyoxyethylene (60) hydrogenated castor oil 0.3
Glycerin 8
1,3-propanediol 3
Monolauric acid sucrose fatty acid ester 0.3
Isopropylmethylphenol 0.05
Citric acid 0.01
Trisodium citrate 0.1
Sodium benzoate 0.2
Perfume 0.1
Purified water Balance
Total 100.0

Formulation example 5
Mouth sprays were prepared according to standard methods.
Ingredient Amount
Sodium lauryl sulfate 0.2
Polyoxyethylene (2) monoalkyl (12-14)
Disodium ether sulfosuccinate 0.3
Polyoxyethylene (60) hydrogenated castor oil 0.15
Glycerin 6
Citric acid 0.1
Trisodium citrate 0.2
Peppermint oil 0.5
l-menthol 0.05
Perfume 0.5
Purified water Balance
Total 100.0

Formulation example 6
A dental rinse was prepared according to a conventional method.
Ingredient Amount
Sodium lauryl sulfate 0.2
Polyoxyethylene (3) monoalkyl (12-14)
Disodium ether sulfosuccinate 0.6
Polyoxyethylene (60) hydrogenated castor oil 0.2
Glycerin 12
Cetylpyridinium chloride 0.05
Sodium citrate 0.2
Saccharin 0.01
Perfume 0.1
Purified water Balance
Total 100.0

Claims (8)

(A) 0.1 to 0.4% by mass of sodium lauryl sulfate,
(B) 0.01 to 1% by mass of a sulfosuccinic acid-based surfactant, and (C) 0.1 to 1% by mass of polyoxyethylene hydrogenated castor oil,
including
The content mass ratio ((A)/(B)) of the component (A) and the component (B) is 0.2 to 6,
pH is 4 to 8;
A liquid oral composition that is substantially free of ethanol (excluding liquid oral compositions having a pH of 6.5 or higher and liquid oral compositions containing cetylpyridinium chloride and panthenol ) . (A) 0.1 to 0.3% by mass of sodium lauryl sulfate,
(B) 0.04 to 0.5% by mass of a sulfosuccinic acid-based surfactant, and (C) 0.1 to 1% by mass of polyoxyethylene hydrogenated castor oil,
including
pH is 4 to 8;
A liquid oral composition substantially free of ethanol (except for liquid oral compositions having a pH of 6.5 or higher and liquid oral compositions containing cetylpyridinium chloride and panthenol ) . The liquid oral composition according to claim 1, comprising 0.03 to 0.6% by mass of component (B). The liquid oral composition according to any one of claims 1 to 3, comprising 0.2 to 0.8% by mass of component (C). Component (B) is at least one selected from the group consisting of polyoxyethylene alkyl (12-14) disodium sulfosuccinate and alkyl (C 12-14) disodium sulfosuccinate, claims 1- 5. The liquid oral composition according to any one of 4. 6. The liquid oral composition according to any one of claims 1 to 5, further comprising at least one flavoring agent selected from the group consisting of anethole, menthol, spearmint oil, mint oil, and peppermint oil. The liquid oral composition according to any one of claims 1 to 6, further comprising 5 to 20% by weight of glycerin. 8. A method for producing the oral composition according to any one of claims 1 to 7, which inhibits precipitation of sodium lauryl sulfate, comprising the step of blending a sulfosuccinic acid-based surfactant and polyoxyethylene hydrogenated castor oil.