JP7352124B2 - How to check the operation of model eyes and ophthalmological imaging equipment - Google Patents

Description

The present disclosure relates to a model eye for use in an ophthalmological imaging device and a method for checking the operation of an ophthalmological imaging device.

Various ophthalmological imaging devices are known for taking images of tissues of an eye to be examined. For example, a scanning ophthalmologic imaging device captures an image of a tissue (eg, fundus, etc.) of an eye to be examined by scanning light. Fundus cameras are also known that take pictures by irradiating the fundus of an eye to be examined with at least one of visible light and infrared light.

When checking the operation of an ophthalmologic imaging device, it is often desirable to use a model eye. For example, the hand-held ophthalmologic device mounting table described in Patent Document 1 includes a mount section on which the hand-held ophthalmologic device and the model eye are placed. By placing the hand-held ophthalmological device and the model eye on each placing section, operation confirmation can be easily performed.

JP2016-34390A

Ophthalmologic imaging devices are known that can perform fluorescent imaging of the fundus of a subject's eye into which a contrast medium has been injected. When confirming the operation of fluorescence imaging, which requires a contrast agent, with the human eye, it is necessary to inject the contrast agent into the subject each time the operation is confirmed. Therefore, it is desirable to use a model eye, especially when checking the operation of fluorescence photography. However, with the conventional eye model, it may not be possible to sufficiently confirm the operation of fluorescence imaging.

A typical object of the present disclosure is to provide an eye model and a method for checking the operation of an ophthalmological photographing apparatus, which can appropriately check the operation of fluorescence photography that requires a contrast agent.

A model eye provided by a typical embodiment of the present disclosure includes a pseudo fundus corresponding to the fundus of a human eye, and a fluorescent substance provided in the pseudo fundus that is used for fluorescence imaging of the fundus of the human eye. a fluorescent part formed of a substance that fluoresces in the photographing light of a wavelength, the fluorescent part being a resin material that fluoresces in the photographing light of a wavelength that causes indocyanine green to fluoresce, and has a fluorescence equivalent to indocyanine green. A fluorescent part for ICGA is formed by dissolving a fluorescent resin material in which a colorless resin is added to a resin material containing a pigment other than indocyanine green, which exhibits characteristics, in an organic solvent, molding it, and then solidifying it. include.

A method for checking the operation of an ophthalmological imaging device provided by a typical embodiment of the present disclosure is a method for checking the operation of an ophthalmological imaging device that captures an image of a tissue by irradiating the tissue of an eye to be examined with imaging light. a photographing step of photographing, with the ophthalmological photographing device, a pseudo fundus of a model eye having a fluorescent part formed of a substance that fluoresces with a photographing light having a wavelength of A fluorescent resin material in which a colorless resin is added to a resin material that fluoresces under the ICGA photographing light, which is the photographing light of It includes an ICGA fluorescent part formed by dissolving in an organic solvent, molding, and solidifying it , and in the photographing step, photographing is performed using the ICGA photographing light.

According to the method for checking the operation of a model eye and an ophthalmological photographing apparatus according to the present disclosure, the operation of fluorescence photography, which requires a contrast agent, can be more appropriately checked.

FIG. 2 is a longitudinal cross-sectional view showing the internal structure of the model eye 1. FIG. FIG. 2 is a left side view of the lens portion 2 and the pseudo fundus portion 3 in an exploded state. FIG. 2 is a perspective view showing the structure of the right half of the model eye 1. FIG. It is a diagram of only the ICGA fluorescent portion 32 of the fluorescent portion 30 formed in the pseudo fundus portion 3 viewed from the front. It is a diagram of only the fluorescent part 33 for FA among the fluorescent parts 30 formed in the pseudo fundus part 3 seen from the front. FIG. 4 is a diagram showing an example of a blood vessel corresponding fluorescent section 40. FIG.

<Summary>
The model eye exemplified in the present disclosure includes a pseudo fundus corresponding to the fundus of a human eye. A fluorescent part is provided in the pseudo fundus part. The fluorescent portion is formed of a material that fluoresces with imaging light of a wavelength that causes a fluorescent material used for fluorescence imaging of the fundus of the human eye to fluoresce. The fluorescent part is made of a material that fluoresces under a photographic light of a wavelength that causes indocyanine green (hereinafter sometimes referred to as "ICG") to fluoresce (hereinafter sometimes referred to as "ICGA photographic light"). Contains a fluorescent part.

By photographing the pseudo fundus of the model eye exemplified in this disclosure using the IGCA photographing light, the operation of ICG fluorescence photographing using the ophthalmological photographing device can be appropriately confirmed without injecting the ICG injection into the subject. It will be done.

Note that the material forming the ICGA fluorescent portion (hereinafter referred to as "ICGA fluorescent material") can be selected as appropriate. Here, rather than using ICG itself, it is preferable to use a substance containing a dye other than ICG (for example, a resin material, etc.) as the fluorescent substance for ICGA. Although ICG is soluble in water, it is relatively difficult to create a model eye using an aqueous solution containing ICG. ICG also has the property of easily changing over time. Therefore, by using a substance containing a dye other than ICG as a fluorescent substance for ICGA, the operation of ICG fluorescence imaging can be more appropriately confirmed.

The fluorescent portion may include an FA fluorescent portion. The FA fluorescent section may be formed of a substance that fluoresces with photographing light having a wavelength that causes fluorescein to fluoresce (hereinafter sometimes referred to as "FA photographing light").

In this case, by photographing the pseudo fundus using the FA photographing light, the operation of the FA fluorescence photographing by the ophthalmological photographing device can be appropriately confirmed without injecting the subject with a fluorescein injection. Note that by providing both the ICGA fluorescent section and the FA fluorescent section in the pseudo eye fundus, the operation confirmation of ICGA fluorescence photography and the operation confirmation of FA fluorescence photography can both be properly performed using one model eye.

Note that the ICGA fluorescent section and the FA fluorescent section may be separately provided at positions in the pseudo fundus that do not completely overlap when viewed from the optical axis direction of the photographing light. In this case, even when ICGA fluorescence imaging and FA fluorescence imaging are performed at the same time, the operation of both fluorescence imaging can be properly confirmed using imaging light that includes both the wavelength that causes ICG to fluoresce and the wavelength that causes fluorescein to fluoresce. . Furthermore, the positions, shapes, etc. of the ICGA fluorescent section and the FA fluorescent section may completely overlap. In this case, the structure of the pseudo fundus is simplified.

At least one of the fluorescent parts (that is, at least one of the ICGA fluorescent part and the FA fluorescent part) is arranged at a plurality of positions at different distances from the optical axis of the model eye, depending on the angle of view of the ophthalmological imaging device. It may include a plurality of viewing angle corresponding fluorescent parts formed respectively. In this case, the state of irradiation of the imaging light onto the plurality of angle-of-view fluorescent sections changes depending on the imaging angle of view of the ophthalmological imaging device. Therefore, the user can appropriately confirm the imaging angle of view of the ophthalmologic imaging device based on the captured fluorescence image.

Note that when both the ICGA fluorescent section and the FA fluorescent section are used as the fluorescent section, the viewing angle compatible fluorescent section may be included in both the ICGA fluorescent section and the FA fluorescent section, or it may be included in only one of them. It may be

At least one of the fluorescent parts (that is, at least one of the ICGA fluorescent part and the FA fluorescent part) may include a blood vessel corresponding fluorescent part imitating the shape of a fundus blood vessel of the human eye. In this case, if the fluorescent video captured by the ophthalmologic imaging device is normal, an image that approximates the fundus image of the human eye will be captured. Therefore, the user can check the operation of the ophthalmologic imaging device with the same feeling as when checking a normal fundus image.

In addition, when using both the fluorescent part for ICGA and the fluorescent part for FA as fluorescent parts, the fluorescent part corresponding to blood vessels may be included in both the fluorescent part for ICGA and the fluorescent part for FA, or it may be included in only one of them. You can leave it there.

At least one of the fluorescent parts (that is, at least one of the ICGA fluorescent part and the FA fluorescent part) may be formed by dissolving a fluorescent resin material in an organic solvent, molding it, and then solidifying it. . In this case, fluorescent parts of various shapes can be easily formed.

Note that a colorless resin (for example, PMMA, etc.) may be added to the fluorescent resin material. In this case, the fluorescence intensity is suitably adjusted by the colorless resin. Further, a specific method for molding the fluorescent resin material can be selected as appropriate. For example, a groove may be formed in the pseudo fundus portion at a position facing the entrance portion side of the lens portion. In this case, the melted fluorescent resin material is poured into the groove and then solidified, thereby easily forming a fluorescent portion with an appropriate shape. Alternatively, the melted fluorescent resin material may be drawn and molded into an appropriate shape. When drawing the fluorescent resin material, a printing machine (for example, an inkjet printer, etc.) may be used.

It is also possible to change the specific method of forming the fluorescent portion. For example, at least one of the fluorescent parts may be formed by heating and melting a solid fluorescent resin material and pouring it into a previously manufactured mold and cooling it. Alternatively, at least one of the fluorescent parts may be formed by heating and melting a solid fluorescent resin material and spinning a candy-like substance. Furthermore, at least one of the fluorescent parts may be formed by transferring a fluorescent substance onto the base material. A fluorescent portion having an appropriate shape may be formed by removing a portion of the fluorescent material formed over a wide area by etching or masking it with a light shielding member. The fluorescent portion may be formed by pouring a liquid fluorescent material into a tube through which photographing light is transmitted and shaping the tube into the shape of the tube.

Note that when both an ICGA fluorescent section and an FA fluorescent section are used as the fluorescent section, the method of forming the ICGA fluorescent section and the FA fluorescent section may be the same or different.

A variable aperture may be provided on the optical axis of the model eye. The size of the pupil of the human eye changes depending on the eye to be examined, the photographing environment, and the like. When checking the operation of an ophthalmologic imaging device, it may be necessary to check whether imaging can be performed appropriately even if the size of the pupil changes. When a variable diaphragm is provided, the user can use the variable diaphragm to confirm the operation of the ophthalmologic photographing apparatus in a pseudo manner when the pupil size changes.

The model eye may further include a lens section. The lens section has a refractive power corresponding to the refractive power of the human eye, and includes an entrance section through which photographing light enters. The pseudo fundus portion may be placed on the optical path of photographing light that enters from the entrance portion and passes through the lens portion. In this case, the operation of the ophthalmological photographing apparatus using the model eye is checked in a situation that is closer to the situation in which the fundus of the human eye is photographed.

A method for checking the operation of an ophthalmological photographing device exemplified in the present disclosure includes a photographing step of photographing, using an ophthalmological photographing device, a pseudo fundus of a model eye that includes a fluorescent portion formed of a substance that fluoresces with photographing light of a specific wavelength. include. The fluorescent portion includes an ICGA fluorescent portion formed of a substance that fluoresces with ICGA photographing light having a wavelength that causes indocyanine green to fluoresce. In the photographing step, photographing is performed using ICGA photographing light. In this case, the operation of ICG fluorescence imaging by the ophthalmological imaging device can be appropriately confirmed without injecting the ICG injection into the subject.

The fluorescent portion of the model eye may include a fluorescent portion for FA. The FA fluorescent section is formed of a substance that fluoresces under FA photographing light having a wavelength that causes fluorescein to fluoresce. In the photographing step, photographing using the ICGA photographing light and photographing using the FA photographing light may be performed simultaneously or by switching. In this case, both the operation confirmation of ICGA fluorescence photography and the operation confirmation of FA fluorescence photography using one ophthalmologic imaging device are appropriately performed using one model eye.

The method for checking the operation of the ophthalmological imaging device may include an adjustment step. In the adjustment step, the imaging conditions of the ophthalmologic imaging device may be adjusted (calibrated) based on the imaging results obtained in the imaging step. In this case, the imaging conditions by the ophthalmological imaging device are appropriately adjusted based on the imaging results of the model eye. In addition, in the adjustment step, it is possible to appropriately adjust various photographing conditions (for example, at least one of the light intensity of the fluorescence photographing light, the gain of the photographing element, etc.).

<Embodiment>
Hereinafter, one typical embodiment according to the present disclosure will be described with reference to the drawings. In the following description, the left side in FIGS. 1 and 2 is the front side of the model eye 1, and the right side in FIGS. 1 and 2 is the back side of the model eye 1. The front side of the paper in FIGS. 1 and 2 is the left side of the model eye 1, and the back side of the paper in FIGS. 1 and 2 is the right side of the model eye 1. The upper and lower sides in FIGS. 1 and 2 are the upper and lower sides of the model eye 1. Further, the lower left side of the paper and the upper right side of the paper in FIG. 3 are the front side and the back side of the model eye 1. The lower right side of the paper and the upper left of the paper in FIG. 3 are the left and right sides of the model eye 1. The upper and lower sides of the paper in FIG. 3 are the upper and lower sides of the model eye 1.

As shown in FIG. 1, the model eye 1 of this embodiment includes a lens section 2, a pseudo fundus section 3, a variable aperture 5, and a housing 6. The lens section 2 has a refractive power corresponding to the refractive power of the human eye, and allows photographing light emitted from the ophthalmologic photographing device to pass toward the pseudo fundus section 3 . The pseudo fundus portion 3 corresponds to the fundus of the human eye. The variable diaphragm 5 changes the size of the aperture located on the optical axis O of the model eye 1 (in this embodiment, the optical axis of the lens section 2). The housing 6 holds the lens section 2, the pseudo fundus section 3, and the variable aperture 5. Each configuration will be explained in detail below.

The lens section 2 includes a lens section main body 21 and an incident section 24 . In this embodiment, the entire lens section 2 including the lens section main body 21 and the entrance section 24 is integrally molded from transparent resin. However, the lens portion may be formed by a plurality of separated members. A space may be formed in a part of the lens portion 2 (for example, inside the lens portion main body). The material for forming the lens portion 2 can be selected as appropriate. As an example, transparent polymethyl methacrylate (PMMA) is used as the material for the lens portion 2 of this embodiment.

In this embodiment, the front side of the lens body 21 is formed into a cylindrical shape whose axis coincides with the optical axis O of the model eye 1. The rear side of the lens body 21 is formed into a substantially hemispherical shape so as to correspond to the shape of the fundus of the human eye as much as possible. Further, the rear side of the entrance portion 24 is formed into a cylindrical shape whose axis coincides with the optical axis O of the model eye 1. The shape of the front surface of the entrance portion 24 is formed along a spherical surface so as to correspond as much as possible to the shape of the cornea of the human eye. In other words, the entrance portion 24 corresponds to the cornea of the human eye. When the lens portion 2 is viewed along the optical axis O, the diameter of the lens portion main body 21 is larger than the diameter of the entrance portion 24.

Imaging light emitted from the ophthalmologic imaging device enters into the lens section 2 from the front surface of the entrance section 24, passes through the entrance section 24 and the inside of the lens section main body 21, and is irradiated onto the pseudo fundus section 3. That is, the pseudo fundus part 3 is provided on the optical path of the photographing light passing through the lens part 2. Furthermore, light from the pseudo fundus 3 (for example, reflected light of the photographing light, fluorescence generated by being irradiated with the photographic light, etc.) passes through the lens body 21 and the entrance section 24, and passes through the entrance section 24. The light is emitted from the front surface of 24 to the ophthalmological imaging device.

The external shape of the pseudo fundus portion 3 is a substantially hemispherical dome shape. As shown in FIG. 1, the inner spherical surface 31 of the pseudo fundus portion 3 corresponds to the rear spherical surface of the lens portion 2. As shown in FIG. 2, the pseudo fundus part 3 is fitted into the lens part main body 21 of the lens part 2 from the rear side. In addition, as shown in FIGS. 1 and 3, in the pseudo fundus part 3, a fluorescent A section 30 is provided. The fluorescent portion 30 is formed of a material that fluoresces with photographing light of a wavelength that causes a fluorescent material used for fluorescence imaging of the fundus of the human eye to fluoresce. Details of the fluorescent section 30 will be described later.

The variable diaphragm 5 changes the size of the aperture 52 located on the optical axis O of the model eye 1, as shown in FIG. The variable diaphragm 5 of this embodiment is arranged in front of the lens section 2. The center of the aperture 52 of the variable diaphragm 5 coincides with the optical axis O of the model eye 1. The variable diaphragm 5 of this embodiment includes an diaphragm adjustment section 51. The size of the aperture 52 is adjusted by rotating the aperture adjustment section 51 by the user. The user can use the variable aperture 5 to confirm the operation of the ophthalmologic photographing apparatus in a pseudo manner when the pupil of the human eye changes.

Note that it is also possible to change the configuration of the variable diaphragm 5. The position where the variable diaphragm 5 is provided does not need to be in front of the lens 2. For example, if a space is provided between the entrance section 24 of the lens section 2 and the spherical surface 31 inside the pseudo fundus section 3, a variable aperture is provided between the entrance section 24 and the spherical surface 31. Good too.

The housing 6 includes a space therein to accommodate each component. The outer shape of the casing 2 of this embodiment is, for example, a substantially cubic shape. The housing 6 of this embodiment includes a front housing 61 and a rear housing 64. An opening 62 having the same diameter as the entrance portion 22 of the lens portion 2 is formed on the front side of the front housing 61 . When the model eye 1 is manufactured, first, the entrance part 22 of the lens part 2 is fitted into the opening 62 of the front housing 61 from behind. Next, the pseudo fundus part 3 is fitted into the lens body 21 of the lens part 2 from behind. Next, the rear housing 64 is fitted into the front housing 61 from behind and fixed. Before or after the above operations, the variable diaphragm 5 is attached to the front side of the front housing 61.

The fluorescent section 30 will be described in detail with reference to FIG. 1 and FIGS. 3 to 5. As described above, the fluorescent portion 30 of this embodiment is provided on the inner spherical surface 31 of the pseudo fundus portion 3. The fluorescent section 30 of this embodiment includes an ICGA fluorescent section 32 and an FA fluorescent section 33.

The ICGA fluorescent section 32 is formed of a substance that fluoresces with photographing light (hereinafter referred to as "ICGA photographing light") having a wavelength (790 nm in this embodiment) that causes indocyanine green (ICG) to fluoresce. Therefore, by photographing the ICGA fluorescence section 32 using the ICGA photographing light, the operation of ICG fluorescence photographing by the ophthalmologic photographing apparatus can be appropriately confirmed.

In this embodiment, the ICGA fluorescent material that fluoresces under the ICGA photographing light is not ICG itself, which easily changes over time, but a material containing a dye other than ICG. As an example, a material manufactured by DIC Corporation is used as the fluorescent material for ICGA in this embodiment (see, for example, Japanese Patent Application Publication No. 2017-72545).

A method for forming the ICGA fluorescent section 32 in this embodiment will be described. First, pellets made of colorless resin (made of PMMA in this embodiment) are added to pellets made of resin (made of PMMA in this embodiment) containing a dye that exhibits fluorescent properties equivalent to those of ICG. The intensity is adjusted to the appropriate intensity. The pellet is then dissolved in an organic solvent. Various solvents (eg, chloroform, acetone, THF, etc.) can be used as the organic solvent. In this embodiment, chloroform is used because it has a fast dissolution rate and requires only a small amount of solvent.

Next, after molding the resin material dissolved in the organic solvent, the organic solvent is dried to solidify the resin material. In this embodiment, a groove 39 is formed at a predetermined position on the inner spherical surface of the pseudo fundus portion 3 . The operator molds the resin material by pouring the melted resin material into the groove 39 .

The FA fluorescent section 33 is formed of a substance that fluoresces with photographing light (hereinafter referred to as "FA photographing light") having a wavelength (488 nm in this embodiment) that causes fluorescein to fluoresce. Therefore, by photographing the FA fluorescent section 33 using the FA photographing light, the operation of FA fluorescence photographing by the ophthalmologic photographing apparatus can be appropriately confirmed. As an example, an acrylic fluorescent dye is used in the FA fluorescent section 33 in this embodiment.

A method of forming the FA fluorescent section 33 in this embodiment will be described. First, pellets made of colorless resin (made of PMMA in this embodiment) are added to pellets made of resin (made of PMMA in this embodiment) containing a dye that exhibits fluorescent properties equivalent to those of fluorescein. The intensity is adjusted to the appropriate intensity. The pellet is then dissolved in an organic solvent. As the organic solvent, various solvents (for example, chloroform, etc.) can be used similarly to the fluorescent part 32 for ICGA. Next, after molding the resin material dissolved in the organic solvent, the organic solvent is dried to solidify the resin material. In this embodiment, similarly to the ICGA fluorescent section 32, the FA fluorescent section 33 is formed by pouring a resin material into the groove 39 of the pseudo fundus section 3.

With reference to FIGS. 4 and 5, the specific arrangement of the fluorescent sections 30 (ICGA fluorescent section 32 and FA fluorescent section 33) in this embodiment will be described in detail. FIG. 4 is a front view showing only the ICGA fluorescent portion 32 of the fluorescent portion 30 formed in the pseudo fundus portion 3. As shown in FIG. Moreover, FIG. 5 is a front view showing only the FA fluorescent part 33 among the fluorescent parts 30 formed in the pseudo fundus part 3.

As shown in FIGS. 4 and 5, the ICGA fluorescent section 32 and the FA fluorescent section 33 of the present embodiment are completely disposed in the pseudo fundus section 3 when viewed from the optical axis direction of the photographing light (that is, from the front side). are provided separately at non-overlapping positions. Specifically, when the pseudo fundus part 3 is viewed from the front side, the ICGA fluorescent part 32 is arranged at the upper left and lower right of the pseudo fundus part 3, and the FA fluorescent part 33 is arranged at the upper right and lower left of the pseudo fundus part. It is located. Therefore, even when ICGA fluorescence imaging and FA fluorescence imaging are executed simultaneously, the operation of both fluorescence imaging can be appropriately confirmed.

As shown in FIG. 4, the ICGA fluorescent section 32 is formed at each of a plurality of positions of the pseudo fundus section 3 at different distances from the optical axis O of the lens section 2, depending on the angle of view of the ophthalmological imaging device. 32A to 32F. Specifically, the angle-of-view fluorescent section 32A coincides with the outer periphery of the photographing range when the photographing angle of view is 20 degrees. The angle-of-view fluorescent section 32B coincides with the outer periphery of the photographing range when the photographing angle of view is 40 degrees. The angle-of-view fluorescent section 32C coincides with the outer periphery of the photographing range when the photographing angle of view is 60 degrees. The angle-of-view fluorescent section 32D coincides with the outer periphery of the photographing range when the photographing angle of view is 80 degrees. The angle-of-view fluorescent section 32E coincides with the outer periphery of the photographing range when the photographing angle of view is 100 degrees. The angle-of-view fluorescent section 32F coincides with the outer periphery of the photographing range when the photographing angle of view is 110 degrees.

Further, as shown in FIG. 5, like the ICGA fluorescent section 32, the FA fluorescent section 33 includes a plurality of viewing angle corresponding fluorescent sections 33A to 33F. The correspondence relationship between each of the plurality of view angle compatible fluorescent parts 33A to 33F and the outer periphery of the photographing range that changes depending on the photographing angle of view is the same as the correspondence relationship in the ICGA fluorescent part 32. The user can appropriately confirm the photographing angle of view of the ophthalmological photographing apparatus based on the fluorescence images taken by the view angle corresponding fluorescent parts 32A to 32F and 33A to 33F.

Note that it is also possible to change the specific configuration of the viewing angle compatible fluorescent sections 32A to 32F and 33A to 33F. For example, the angle-of-view fluorescent portion may be formed in the shape of at least one of a number and a scale indicating the corresponding angle of view.

As explained above, the model eye 1 of this embodiment includes both the ICGA fluorescent section 32 and the FA fluorescent section 33. Therefore, the user can also use the model eye 1 of this embodiment when checking the operation of an ophthalmological imaging device (for example, an SLO device or a fundus camera) that can perform both ICGA fluorescence imaging and FA fluorescence imaging. Can be used. Furthermore, the model eye 1 may also be used when checking the operation of another ophthalmological imaging device 1 (for example, an OCT device, etc.). It goes without saying that the model eye 1 of this embodiment can also be used to confirm the operation of an ophthalmologic imaging apparatus that can perform only one of ICGA fluorescence imaging and FA fluorescence imaging.

Next, a method for checking the operation of the ophthalmologic imaging apparatus in this embodiment will be described. The operation confirmation method in this embodiment includes a photographing process and an adjustment process.

In the photographing process, the pseudo fundus portion 3 of the model eye 1 including the fluorescent portion 30 is photographed by an ophthalmologic photographing device (for example, an SLO device). Here, as described above, the fluorescent section 30 of the model eye 1 includes both the ICGA fluorescent section 32 and the FA fluorescent section 33. In the photographing process of this embodiment, photographing using ICGA photographing light and photographing using FA photographing light are performed simultaneously or by switching. Therefore, both the operation confirmation of ICGA fluorescence photography and the operation confirmation of FA fluorescence photography using one ophthalmologic imaging device are appropriately performed using one model eye 1. Furthermore, the angle of view of the ophthalmologic imaging device is also appropriately confirmed. However, it goes without saying that only one of the operation confirmation for ICGA fluorescence photography and the operation confirmation for FA fluorescence photography may be performed.

In the adjustment process, based on the photographing results of the photographing process (for example, the brightness value of the photographed image, etc.), the photographing conditions of the ophthalmological photographing device (for example, at least one of the light intensity of the photographing light and the gain of the photographing element, etc.) are adjusted. ) is adjusted. In this embodiment, the imaging conditions for ICGA fluorescence imaging are adjusted based on the results of ICGA fluorescence imaging, and the imaging conditions for FA fluorescence imaging are adjusted based on the results of FA fluorescence imaging.

The techniques disclosed in the above embodiments are merely examples. Therefore, it is also possible to modify the techniques exemplified in the above embodiments. Here, a modification of the fluorescent portion will be described with reference to FIG. 6. A blood vessel corresponding fluorescent part 40 is formed in the simulated fundus part 3 shown in FIG. The blood vessel corresponding fluorescent part 40 is a fluorescent part formed to imitate the shape of the fundus structure of the human eye (in particular, the fundus blood vessels). Therefore, if the operation of fluorescence photography by the ophthalmologic imaging device is normal, a fluorescence image that approximates a fluorescence image of the fundus of the human eye will be photographed.

It is also possible to implement only some of the techniques exemplified in the above embodiments. For example, the fluorescent section 30 of the above embodiment includes both an ICGA fluorescent section 32 and an FA fluorescent section 33. However, the fluorescent section 30 may include only the ICGA fluorescent section 32. Further, the model eye may not include the ICGA fluorescent section 32, but only the FA fluorescent section 33, which is the viewing angle corresponding fluorescent sections 33A to 33F. In this case, the model eye can also be expressed as follows. a lens section having a refractive power equivalent to the refractive power of the human eye and including an entrance section into which photographing light emitted from an ophthalmological imaging device is incident; and the photographing light that is input from the entrance section and passes through the lens section. a pseudo-fundus portion corresponding to the fundus of the human eye, which is disposed on the optical path of the fundus, and a fluorescent material used for fluorescence imaging of the fundus of the human eye, at a position of the pseudo-fundus portion facing at least the incident section side. a fluorescent portion formed of a substance that fluoresces with the photographing light having a wavelength that causes the fluorescence to fluoresce; includes a plurality of viewing angle corresponding fluorescent parts formed at a plurality of positions each having a different distance from the optical axis of the part.

1 Model eye 2 Lens section 3 Pseudo fundus section 5 Variable diaphragm 22 Entrance section 30 Fluorescent section 32 Fluorescent section for ICGA 33 Fluorescent section for FA 32A to 32F, 33A to 33F Angle of view fluorescent section 40 Fluorescent section for blood vessels

Claims (4)

a pseudo fundus corresponding to the fundus of the human eye;
a fluorescent part provided in the pseudo fundus part and formed of a substance that fluoresces with imaging light of a wavelength that makes a fluorescent substance used for fluorescence photography of the fundus of a human eye fluoresce;
Equipped with
The fluorescent portion is a resin material that fluoresces under the photographing light having a wavelength that causes indocyanine green to fluoresce, and a colorless resin is added to the resin material containing a pigment other than indocyanine green that exhibits fluorescence characteristics equivalent to indocyanine green. A model eye comprising an ICGA fluorescent part formed by dissolving an added fluorescent resin material in an organic solvent, molding it, and then solidifying it. The model eye according to claim 1,
The model eye is characterized in that the fluorescent part includes an FA fluorescent part formed of a substance that fluoresces with the photographing light having a wavelength that causes fluorescein to fluoresce. The model eye according to claim 1 or 2,
At least one of the fluorescent parts has a plurality of angles of view formed at each of a plurality of positions having different distances from the optical axis of the model eye, depending on the angle of view of imaging by the ophthalmological imaging device that emits the imaging light. A model eye characterized by including a corresponding fluorescent part. A method for checking the operation of an ophthalmologic imaging device that captures an image of a tissue by irradiating the tissue of an eye to be examined with imaging light, the method comprising:
a photographing step of photographing a pseudo fundus of a model eye, which is equipped with a fluorescent portion formed of a substance that fluoresces with photographing light of a specific wavelength, using the ophthalmological photographing device;
The fluorescent portion is a resin material that fluoresces under the ICGA photographing light, which is the photographing light having a wavelength that causes indocyanine green to fluoresce, and is a resin material containing a pigment other than indocyanine green that exhibits fluorescence characteristics equivalent to indocyanine green. includes a fluorescent part for ICGA formed by dissolving a fluorescent resin material to which a colorless resin is added in an organic solvent, molding it, and then solidifying it;
In the photographing step, photographing is performed using the ICGA photographing light.

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