JP7353103B2 - Nutritional supplement composition and method for producing the same, method for suppressing unpleasant odor of a nutritional supplement composition, and composition for suppressing unpleasant odor of a nutritional supplement composition - Google Patents
Nutritional supplement composition and method for producing the same, method for suppressing unpleasant odor of a nutritional supplement composition, and composition for suppressing unpleasant odor of a nutritional supplement composition Download PDFInfo
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- JP7353103B2 JP7353103B2 JP2019152953A JP2019152953A JP7353103B2 JP 7353103 B2 JP7353103 B2 JP 7353103B2 JP 2019152953 A JP2019152953 A JP 2019152953A JP 2019152953 A JP2019152953 A JP 2019152953A JP 7353103 B2 JP7353103 B2 JP 7353103B2
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- Prior art keywords
- vitamin
- nutritional supplement
- mass
- unpleasant odor
- amino acid
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- 229920003124 powdered cellulose Polymers 0.000 description 1
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- 102000004169 proteins and genes Human genes 0.000 description 1
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- 229960003581 pyridoxal Drugs 0.000 description 1
- 235000008164 pyridoxal Nutrition 0.000 description 1
- 239000011674 pyridoxal Substances 0.000 description 1
- 235000007682 pyridoxal 5'-phosphate Nutrition 0.000 description 1
- 239000011589 pyridoxal 5'-phosphate Substances 0.000 description 1
- 229960001327 pyridoxal phosphate Drugs 0.000 description 1
- 235000008151 pyridoxamine Nutrition 0.000 description 1
- 239000011699 pyridoxamine Substances 0.000 description 1
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- 239000011677 pyridoxine Substances 0.000 description 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 description 1
- 235000019171 pyridoxine hydrochloride Nutrition 0.000 description 1
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- 229960004172 pyridoxine hydrochloride Drugs 0.000 description 1
- 229960000342 retinol acetate Drugs 0.000 description 1
- QGNJRVVDBSJHIZ-QHLGVNSISA-N retinyl acetate Chemical compound CC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C QGNJRVVDBSJHIZ-QHLGVNSISA-N 0.000 description 1
- 235000019173 retinyl acetate Nutrition 0.000 description 1
- 239000011770 retinyl acetate Substances 0.000 description 1
- 229950001574 riboflavin phosphate Drugs 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 239000004576 sand Substances 0.000 description 1
- 235000020637 scallop Nutrition 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229940007115 shark cartilage extract Drugs 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 229940023144 sodium glycolate Drugs 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960001385 thiamine disulfide Drugs 0.000 description 1
- UIERGBJEBXXIGO-UHFFFAOYSA-N thiamine mononitrate Chemical compound [O-][N+]([O-])=O.CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N UIERGBJEBXXIGO-UHFFFAOYSA-N 0.000 description 1
- 235000008170 thiamine pyrophosphate Nutrition 0.000 description 1
- 239000011678 thiamine pyrophosphate Substances 0.000 description 1
- YXVCLPJQTZXJLH-UHFFFAOYSA-N thiamine(1+) diphosphate chloride Chemical compound [Cl-].CC1=C(CCOP(O)(=O)OP(O)(O)=O)SC=[N+]1CC1=CN=C(C)N=C1N YXVCLPJQTZXJLH-UHFFFAOYSA-N 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 229960002663 thioctic acid Drugs 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- JEJAMASKDTUEBZ-UHFFFAOYSA-N tris(1,1,3-tribromo-2,2-dimethylpropyl) phosphate Chemical compound BrCC(C)(C)C(Br)(Br)OP(=O)(OC(Br)(Br)C(C)(C)CBr)OC(Br)(Br)C(C)(C)CBr JEJAMASKDTUEBZ-UHFFFAOYSA-N 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
本発明は、栄養補助組成物及びその製造方法、栄養補助組成物の不快臭の抑制方法、並びに栄養補助組成物の不快臭抑制用組成物に関する。 The present invention relates to a nutritional supplement composition, a method for producing the same, a method for suppressing unpleasant odor of a nutritional supplement composition, and a composition for suppressing unpleasant odor of a nutritional supplement composition.
近年、不規則な食生活や美容への意識の高まりなどに伴い、必要な栄養素を効率的に補給するため、アミノ酸、ビタミン、ミネラル等の栄養素を含有する栄養補助食品やサプリメントといった栄養補助組成物の需要が高まっている。 In recent years, with irregular eating habits and increasing awareness of beauty, nutritional supplement compositions such as nutritional supplements and supplements containing nutrients such as amino acids, vitamins, and minerals have been developed to efficiently supply necessary nutrients. demand is increasing.
前記栄養補助組成物には、様々な成分(以下、「原料」と称することもある。)が含まれており、前記原料の中には、原料自体が好ましくない臭いを呈するものがあることが知られている。このような臭いは、栄養補助組成物の製品価値を低下させてしまうという問題がある。 The nutritional supplement composition contains various ingredients (hereinafter sometimes referred to as "raw materials"), and some of the raw materials themselves may have an unpleasant odor. Are known. Such odor poses a problem in that it reduces the product value of the nutritional supplement composition.
前記原料自体の臭いが問題となる成分として、例えば、ビタミンB1が知られている。
前記ビタミンB1の臭いを低減する技術としては、例えば、コンドロイチン硫酸塩を配合する技術(例えば、特許文献1参照)、発酵セルロースを配合する技術(例えば、特許文献2参照)などが提案されている。
For example, vitamin B1 is known as a component that causes a problem with the odor of the raw material itself.
As techniques for reducing the odor of vitamin B1, for example, a technique of blending chondroitin sulfate (for example, see Patent Document 1), a technique of blending fermented cellulose (for example, see Patent Document 2), etc. have been proposed. .
上述したように、栄養補助組成物の製品価値の低下を抑制することができる技術の様々な検討が行われているのが現状である。 As mentioned above, various studies are currently being conducted on techniques that can suppress the decline in product value of nutritional supplement compositions.
本発明者らは、ビタミンB群から選択される少なくとも1種の化合物と、アミノ酸又はその塩とを含有する栄養補助組成物が、保管中、特に高温・多湿環境下で保管すると、原料自体の臭いとは異なる、ヒトが不快と感じる不快臭が生じることを見出した。前記高温・多湿環境は、例えば、夏場の環境が該当する。 The present inventors have discovered that when a nutritional supplement composition containing at least one compound selected from the B group of vitamins and an amino acid or its salt is stored, especially in a high temperature and humid environment, the raw materials themselves deteriorate. It was discovered that an unpleasant odor that humans find unpleasant, which is different from odor, is generated. The high temperature/humid environment corresponds to, for example, a summer environment.
本発明は、従来における前記諸問題を解決し、以下の目的を達成することを課題とする。即ち、本発明は、ビタミンB群から選択される少なくとも1種の化合物と、アミノ酸又はその塩とを含有する栄養補助組成物を保管、特に高温・多湿環境下に保管した場合に生じる不快臭を抑制することができる栄養補助組成物及びその製造方法、栄養補助組成物の不快臭の抑制方法、並びに栄養補助組成物の不快臭抑制用組成物を提供することを目的とする。 The present invention aims to solve the above-mentioned conventional problems and achieve the following objects. That is, the present invention aims to reduce the unpleasant odor that occurs when a nutritional supplement composition containing at least one compound selected from the vitamin B group and an amino acid or a salt thereof is stored, especially when stored in a high temperature and humid environment. The present invention aims to provide a nutritional supplement composition that can suppress unpleasant odor, a method for producing the same, a method for suppressing unpleasant odor of a nutritional supplement composition, and a composition for suppressing unpleasant odor of a nutritional supplement composition.
前記課題を解決するため、本発明者らは鋭意検討した結果、ビタミンB群から選択される少なくとも1種の化合物と、アミノ酸又はその塩とを含有する栄養補助組成物に、無機多孔質体を含有させるという簡易な手段により、高温・多湿環境下に保存した場合であっても、ビタミンB群から選択される少なくとも1種の化合物と、アミノ酸又はその塩とが共存することにより生じる不快臭を低減することができることを知見した。 In order to solve the above-mentioned problems, the present inventors conducted intensive studies and found that an inorganic porous material was added to a nutritional supplement composition containing at least one compound selected from the vitamin B group and an amino acid or a salt thereof. Even when stored in a high temperature and humid environment, the unpleasant odor caused by the coexistence of at least one compound selected from the vitamin B group and an amino acid or its salt can be eliminated by the simple method of containing the amino acid or its salt. We have found that it is possible to reduce
本発明は、本発明者らの前記知見に基づくものであり、前記課題を解決するための手段としては、以下の通りである。即ち、
<1> (A)ビタミンB群から選択される少なくとも1種の化合物と、
(B)アミノ酸又はその塩と、
(C)無機多孔質体とを含有することを特徴とする栄養補助組成物である。
<2> 前記(C)無機多孔質体が、ケイ酸塩である前記<1>に記載の栄養補助組成物である。
<3> 前記(C)無機多孔質体が、ケイ酸カルシウムである前記<1>に記載の栄養補助組成物である。
<4> 前記(A)ビタミンB群から選択される少なくとも1種の化合物が、ビタミンB1及びビタミンB6を含む前記<1>から<3>のいずれかに記載の栄養補助組成物である。
<5> 前記(A)成分のビタミンB1及びビタミンB6の合計量と、前記(B)アミノ酸又はその塩との質量比[{(ビタミンB1)+(ビタミンB6)}/(アミノ酸又はその塩)]が、0.1超である前記<4>に記載の栄養補助組成物である。
<6> 前記(A)ビタミンB群から選択される少なくとも1種の化合物の合計量と、前記(B)アミノ酸又はその塩との質量比{(ビタミンB群から選択される少なくとも1種の化合物の合計量)/(アミノ酸又はその塩)}が、0.1超である前記<1>から<5>のいずれかに記載の栄養補助組成物である。
<7> (A)ビタミンB群から選択される少なくとも1種の化合物と、(B)アミノ酸又はその塩と、(C)無機多孔質体とを混合する混合工程を含むことを特徴とする栄養補助組成物の製造方法である。
<8> 前記混合工程が、前記(A)ビタミンB群から選択される少なくとも1種の化合物と、前記(C)無機多孔質体とを混合する第1の混合処理と、
前記第1の混合処理で得られた混合物と、前記(B)アミノ酸又はその塩とを混合する第2の混合処理とを含む前記<7>に記載の栄養補助組成物の製造方法である。
<9> (A)ビタミンB群から選択される少なくとも1種の化合物と、(B)アミノ酸又はその塩とを含有する栄養補助組成物の不快臭の抑制方法であって、
前記(A)ビタミンB群から選択される少なくとも1種の化合物と、前記(B)アミノ酸又はその塩と、(C)無機多孔質体とを混合する混合工程を含むことを特徴とする不快臭の抑制方法である。
<10> 前記混合工程が、前記(A)ビタミンB群から選択される少なくとも1種の化合物と、前記(C)無機多孔質体とを混合する第1の混合処理と、
前記第1の混合処理で得られた混合物と、前記(B)アミノ酸又はその塩とを混合する第2の混合処理とを含む前記<9>に記載の不快臭の抑制方法である。
<11> ビタミンB群から選択される少なくとも1種の化合物と、アミノ酸又はその塩とを含有する栄養補助組成物の不快臭を抑制するために用いられ、
無機多孔質体を含有することを特徴とする不快臭抑制用組成物である。
The present invention is based on the above findings of the present inventors, and means for solving the above problems are as follows. That is,
<1> (A) at least one compound selected from the vitamin B group;
(B) an amino acid or a salt thereof;
(C) A nutritional supplement composition characterized by containing an inorganic porous body.
<2> The nutritional supplement composition according to <1> above, wherein the inorganic porous body (C) is a silicate.
<3> The nutritional supplement composition according to <1> above, wherein the inorganic porous material (C) is calcium silicate.
<4> The nutritional supplement composition according to any one of <1> to <3>, wherein the at least one compound selected from the vitamin B group (A) contains vitamin B1 and vitamin B6.
<5> Mass ratio of the total amount of vitamin B1 and vitamin B6 of the component (A) to the amino acid or salt thereof (B) [{(vitamin B1) + (vitamin B6)}/(amino acid or salt thereof) ] is more than 0.1, the nutritional supplement composition according to <4> above.
<6> Mass ratio of the total amount of the (A) at least one compound selected from the vitamin B group to the (B) amino acid or its salt {(at least one compound selected from the vitamin B group) The nutritional supplement composition according to any one of <1> to <5>, wherein the total amount of amino acid or amino acid or its salt} is more than 0.1.
<7> Nutrition characterized by including a mixing step of mixing (A) at least one compound selected from the vitamin B group, (B) an amino acid or a salt thereof, and (C) an inorganic porous body. A method for producing an auxiliary composition.
<8> A first mixing process in which the mixing step mixes the (A) at least one compound selected from the vitamin B group and the (C) inorganic porous body;
The method for producing a nutritional supplement composition according to <7> above includes a second mixing process of mixing the mixture obtained in the first mixing process and the amino acid (B) or a salt thereof.
<9> A method for suppressing unpleasant odor of a nutritional supplement composition containing (A) at least one compound selected from the vitamin B group and (B) an amino acid or a salt thereof,
An unpleasant odor characterized by comprising a mixing step of mixing the (A) at least one compound selected from the vitamin B group, the (B) amino acid or its salt, and (C) the inorganic porous material. This is a method of suppressing
<10> A first mixing process in which the mixing step mixes the (A) at least one compound selected from the vitamin B group and the (C) inorganic porous body;
The method for suppressing unpleasant odor according to <9> above includes a second mixing process of mixing the mixture obtained in the first mixing process and the amino acid (B) or its salt.
<11> Used for suppressing unpleasant odor of a nutritional supplement composition containing at least one compound selected from the vitamin B group and an amino acid or a salt thereof,
This is an unpleasant odor suppressing composition characterized by containing an inorganic porous material.
本発明によれば、従来における前記諸問題を解決し、前記目的を達成することができ、ビタミンB群から選択される少なくとも1種の化合物と、アミノ酸又はその塩とを含有する栄養補助組成物を保管、特に高温・多湿環境下に保管した場合に生じる不快臭を抑制することができる栄養補助組成物及びその製造方法、栄養補助組成物の不快臭の抑制方法、並びに栄養補助組成物の不快臭抑制用組成物を提供することができる。 According to the present invention, there is provided a nutritional supplement composition which can solve the above-mentioned conventional problems and achieve the above-mentioned objectives, and which contains at least one compound selected from the vitamin B group and an amino acid or a salt thereof. A nutritional supplement composition capable of suppressing unpleasant odors that occur when stored, especially in a high temperature and humid environment, and a method for producing the same, a method for suppressing unpleasant odor of a nutritional supplement composition, and an unpleasant odor of a nutritional supplement composition. Odor control compositions can be provided.
(栄養補助組成物)
本発明の栄養補助組成物は、(A)ビタミンB群から選択される少なくとも1種の化合物(以下、「(A)成分」と称することがある。)と、(B)アミノ酸又はその塩(以下、「(B)成分」と称することがある。)と、(C)無機多孔質体(以下、「(C)成分」と称することがある。)とを少なくとも含み、必要に応じて更にその他の成分を含む。
(Nutritional supplement composition)
The nutritional supplement composition of the present invention comprises (A) at least one compound selected from the vitamin B group (hereinafter sometimes referred to as "component (A)"), and (B) an amino acid or a salt thereof ( (hereinafter sometimes referred to as "component (B)"); and (C) an inorganic porous material (hereinafter sometimes referred to as "component (C)"); Contains other ingredients.
<(A)ビタミンB群から選択される少なくとも1種の化合物>
本発明において、前記ビタミンB群の化合物とは、ビタミンB1、ビタミンB2、ビタミンB3、ビタミンB5、ビタミンB6、ビタミンB7、ビタミンB9、及びビタミンB12のことをいう。これらは、1種単独で使用してもよいし、2種以上を併用してもよい。
前記ビタミンB群の化合物は、市販品を適宜使用することができる。
<(A) At least one compound selected from vitamin B group>
In the present invention, the vitamin B group compounds refer to vitamin B1, vitamin B2, vitamin B3, vitamin B5, vitamin B6, vitamin B7, vitamin B9, and vitamin B12. These may be used alone or in combination of two or more.
As the vitamin B group compound, commercially available products can be used as appropriate.
前記栄養補助組成物は、前記ビタミンB群の化合物の中でも、ビタミンB1及びビタミンB6を含むことが好ましい。 The nutritional supplement composition preferably contains vitamin B1 and vitamin B6 among the vitamin B group compounds.
前記ビタミンB1には、チアミン及びその誘導体、並びにそれらの塩が含まれる。
前記誘導体としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、ビスチアミン、チアミンジスルフィド、ジセチアミン、フルスルチアミン、オクトチアミン、シコチアミン、ビスイブチアミン、ビスベンチアミン、プロスルチアミン、ベンフォチアミン、チアミン二リン酸などが挙げられる。
前記塩としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、硝酸塩、塩酸塩、硫酸塩等の無機酸塩などが挙げられる。
前記ビタミンB1は、1種単独で使用してもよいし、2種以上を併用してもよい。
The vitamin B1 includes thiamine, its derivatives, and salts thereof.
The derivatives are not particularly limited and can be selected as appropriate depending on the purpose, for example, bisthiamine, thiamine disulfide, dicethiamine, fursulthiamine, octothiamine, cicothiamine, bisbuthiamine, bisbenthiamine, prosulthiamine. , benfotiamine, thiamine diphosphate, etc.
The salt is not particularly limited and can be appropriately selected depending on the purpose, and includes, for example, inorganic acid salts such as nitrates, hydrochlorides, and sulfates.
The vitamin B1 may be used alone or in combination of two or more.
前記ビタミンB2には、リボフラビン及びその誘導体、並びにそれらの塩が含まれる。
前記誘導体としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、リン酸リボフラビン、酪酸リボフラビン、フラビンアデニンジヌクレオチドなどが挙げられる。
前記塩としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、ナトリウム塩等のアルカリ金属塩などが挙げられる。
前記ビタミンB2は、1種単独で使用してもよいし、2種以上を併用してもよい。
The vitamin B2 includes riboflavin, derivatives thereof, and salts thereof.
The derivatives are not particularly limited and can be appropriately selected depending on the purpose, and include, for example, riboflavin phosphate, riboflavin butyrate, flavin adenine dinucleotide, and the like.
The salt is not particularly limited and can be appropriately selected depending on the purpose, and includes, for example, alkali metal salts such as sodium salts.
The vitamin B2 may be used alone or in combination of two or more.
前記ビタミンB3には、ニコチン酸、ニコチン酸アミド及びそれらの誘導体、並びにそれらの塩が含まれる。
前記誘導体としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、イノシトールヘキサニコチネート、ニコチン酸アミドアデニンジヌクレオチド、ニコチン酸アミドアデニンジヌクレオチドリン酸、へプロニカートなどが挙げられる。
前記塩としては、特に制限はなく、目的に応じて適宜選択することができる。
前記ビタミンB3は、1種単独で使用してもよいし、2種以上を併用してもよい。
The vitamin B3 includes nicotinic acid, nicotinamide, derivatives thereof, and salts thereof.
The derivatives are not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include inositol hexanicotinate, nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, hepronicat, and the like. .
The salt is not particularly limited and can be appropriately selected depending on the purpose.
The vitamin B3 may be used alone or in combination of two or more.
前記ビタミンB5には、パントテン酸及びその誘導体、並びにそれらの塩が含まれる。
前記誘導体としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、パンテノール、パンテチン、パンテテイン、補酵素Aなどが挙げられる。
前記塩としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、ナトリウム塩等のアルカリ金属塩、カルシウム塩等のアルカリ土類金属塩などが挙げられる。
前記ビタミンB5は、1種単独で使用してもよいし、2種以上を併用してもよい。
The vitamin B5 includes pantothenic acid, derivatives thereof, and salts thereof.
The derivatives are not particularly limited and can be appropriately selected depending on the purpose, and include, for example, panthenol, pantethine, pantetheine, coenzyme A, and the like.
The salt is not particularly limited and can be appropriately selected depending on the purpose, and includes, for example, alkali metal salts such as sodium salts, alkaline earth metal salts such as calcium salts, and the like.
The vitamin B5 may be used alone or in combination of two or more.
前記ビタミンB6には、ピリドキシン、ピリドキサミン、ピリドキサール及びそれらの誘導体、並びにそれらの塩が含まれる。
前記誘導体としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、リン酸ピリドキサールなどが挙げられる。
前記塩としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、カルシウム塩等のアルカリ土類金属塩、塩酸塩等の無機酸塩などが挙げられる。
前記ビタミンB6は、1種単独で使用してもよいし、2種以上を併用してもよい。
The vitamin B6 includes pyridoxine, pyridoxamine, pyridoxal, derivatives thereof, and salts thereof.
The derivative is not particularly limited and can be appropriately selected depending on the purpose, such as pyridoxal phosphate.
The salt is not particularly limited and can be appropriately selected depending on the purpose, and includes, for example, alkaline earth metal salts such as calcium salts, and inorganic acid salts such as hydrochloride.
The vitamin B6 may be used alone or in combination of two or more.
前記ビタミンB7には、ビオチン及びその塩が含まれる。
前記塩としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、ナトリウム塩等のアルカリ金属塩などが挙げられる。
前記ビタミンB7は、1種単独で使用してもよいし、2種以上を併用してもよい。
The vitamin B7 includes biotin and its salts.
The salt is not particularly limited and can be appropriately selected depending on the purpose, and includes, for example, alkali metal salts such as sodium salts.
The vitamin B7 may be used alone or in combination of two or more.
前記ビタミンB9には、葉酸及びその誘導体、並びにそれらの塩が含まれる。
前記誘導体としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、ジヒドロ葉酸、テトラヒドロ葉酸などが挙げられる。
前記塩としては、特に制限はなく、目的に応じて適宜選択することができる。
前記ビタミンB9は、1種単独で使用してもよいし、2種以上を併用してもよい。
The vitamin B9 includes folic acid, derivatives thereof, and salts thereof.
The derivatives are not particularly limited and can be appropriately selected depending on the purpose, and include, for example, dihydrofolic acid, tetrahydrofolic acid, and the like.
The salt is not particularly limited and can be appropriately selected depending on the purpose.
The vitamin B9 may be used alone or in combination of two or more.
前記ビタミンB12には、シアノコバラミン、ヒドロキソコバラミン、アデノシルコバラミン、メチルコバラミン及びそれらの誘導体、並びにそれらの塩が含まれる。
前記誘導体としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、メコバラミン、デオキシアデノシルコバラミンなどが挙げられる。
前記塩としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、塩酸塩等の無機酸塩、酢酸塩等の有機酸塩などが挙げられる。
前記ビタミンB12は、1種単独で使用してもよいし、2種以上を併用してもよい。
The vitamin B12 includes cyanocobalamin, hydroxocobalamin, adenosylcobalamin, methylcobalamin, derivatives thereof, and salts thereof.
The derivative is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include mecobalamin, deoxyadenosylcobalamin, and the like.
The salt is not particularly limited and can be appropriately selected depending on the purpose, and includes, for example, inorganic acid salts such as hydrochloride, organic acid salts such as acetate, and the like.
The vitamin B12 may be used alone or in combination of two or more.
前記(A)成分の前記栄養補助組成物における含有量としては、特に制限はなく、目的に応じて適宜選択することができるが、前記栄養補助組成物100質量部に対して、前記(A)成分の合計量として、1質量部以上が好ましく、10質量部以上がより好ましく、20質量部以上が特に好ましい。前記含有量が好ましい範囲内であると、成分補給目的での摂取量を満たせる点で、有利である。 The content of the component (A) in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose. The total amount of the components is preferably 1 part by mass or more, more preferably 10 parts by mass or more, and particularly preferably 20 parts by mass or more. When the content is within a preferable range, it is advantageous in that the intake amount for the purpose of supplementing the ingredients can be satisfied.
前記栄養補助組成物に含まれる前記ビタミンB群の各化合物の含有割合としては、特に制限はなく、目的に応じて適宜選択することができる。 The content ratio of each compound of the vitamin B group contained in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose.
<(B)アミノ酸又はその塩>
前記アミノ酸又はその塩としては、特に制限はなく、目的に応じて適宜選択することができる。
前記アミノ酸の塩としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、塩酸塩、硫酸塩、酢酸塩等の無機酸又は有機酸との塩、ナトリウム塩、カリウム塩等の塩基との塩などが挙げられる。
前記アミノ酸又はその塩は、1種単独で使用してもよいし、2種以上を併用してもよい。
前記アミノ酸又はその塩は、市販品を適宜使用することができる。
<(B) Amino acid or its salt>
The amino acid or its salt is not particularly limited and can be appropriately selected depending on the purpose.
The salt of the amino acid is not particularly limited and can be selected as appropriate depending on the purpose, for example, salts with inorganic or organic acids such as hydrochloride, sulfate, acetate, sodium salt, potassium salt, etc. Examples include salts with bases.
The amino acids or salts thereof may be used alone or in combination of two or more.
As the amino acid or its salt, commercially available products can be used as appropriate.
前記アミノ酸又はその塩の中でも、アミノ酸が、ロイシン、スレオニン、プロリン、バリン、イソロイシン、メチオニン、フェニルアラニン、トリプトファン、リジン、アスパラギン、アスパラギン酸、セリン、ヒスチジン、グリシン、アルギニン、グルタミン酸、アラニン、システイン(シスチンの態様を含む。以下同様。)、チロシン、グルタミン、シトルリンであることが好ましく、ロイシン、バリン、イソロイシン、フェニルアラニン、セリン、ヒスチジン、グリシン、アルギニン、グルタミン酸、アラニン、システイン、チロシン、グルタミン、シトルリンであるものがより好ましく、ロイシンであるものが特に好ましい。前記好ましいアミノ酸又はその塩を含む前記栄養補助組成物は、前記不快臭が発生しやすいが、本発明によれば、前記不快臭を抑制することができる。 Among the amino acids or salts thereof, the amino acids include leucine, threonine, proline, valine, isoleucine, methionine, phenylalanine, tryptophan, lysine, asparagine, aspartic acid, serine, histidine, glycine, arginine, glutamic acid, alanine, cysteine ), tyrosine, glutamine, and citrulline, preferably leucine, valine, isoleucine, phenylalanine, serine, histidine, glycine, arginine, glutamic acid, alanine, cysteine, tyrosine, glutamine, and citrulline. is more preferred, and leucine is particularly preferred. The nutritional supplement composition containing the preferable amino acid or its salt tends to generate the unpleasant odor, but according to the present invention, the unpleasant odor can be suppressed.
前記(B)成分の前記栄養補助組成物における含有量としては、特に制限はなく、目的に応じて適宜選択することができるが、前記栄養補助組成物100質量部に対して、前記(B)成分の合計量として、0.1質量部~70質量部が好ましく、1質量部~60質量部がより好ましく、2質量部~50質量部が特に好ましい。前記含有量が好ましい範囲内であると、成分補給目的での摂取量を満たせる点で、有利である。 The content of the component (B) in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose. The total amount of the components is preferably 0.1 parts by weight to 70 parts by weight, more preferably 1 part to 60 parts by weight, and particularly preferably 2 parts by weight to 50 parts by weight. When the content is within a preferable range, it is advantageous in that the intake amount for the purpose of supplementing the ingredients can be met.
前記栄養補助組成物に含まれる前記アミノ酸又はその塩の各化合物の含有割合としては、特に制限はなく、目的に応じて適宜選択することができる。 The content ratio of each compound of the amino acid or its salt contained in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose.
前記(A)成分と、前記(B)成分との質量比(A)/(B)としては、特に制限はなく、目的に応じて適宜選択することができる。
例えば、前記(A)成分が、ビタミンB1及びビタミンB6を含む場合、前記ビタミンB1及びビタミンB6の合計量と、前記(B)成分との質量比[{(ビタミンB1)+(ビタミンB6)}/(B成分)]としては、特に制限はなく、目的に応じて適宜選択することができるが、0.1超であることが好ましく、1以上であることがより好ましく、2.5以上であることが特に好ましい。また、前記(A)成分の合計量と、前記(B)成分の量との質量比{(A)成分の合計量}/(B)成分}としては、特に制限はなく、目的に応じて適宜選択することができるが、0.1超であることが好ましく、1以上であることがより好ましく、2.5以上であることが特に好ましい。前記好ましい範囲である前記栄養補助組成物は前記不快臭が発生しやすいが、本発明によれば、前記不快臭を抑制することができる。
The mass ratio (A)/(B) of the component (A) to the component (B) is not particularly limited and can be appropriately selected depending on the purpose.
For example, when the component (A) contains vitamin B1 and vitamin B6, the mass ratio of the total amount of the vitamin B1 and vitamin B6 to the component (B) [{(vitamin B1)+(vitamin B6)} /(B component)] is not particularly limited and can be appropriately selected depending on the purpose, but it is preferably over 0.1, more preferably 1 or more, and 2.5 or more. It is particularly preferable that there be. In addition, there is no particular restriction on the mass ratio between the total amount of the (A) component and the amount of the (B) component {total amount of the (A) component}/(B) component}, and it can be changed depending on the purpose. Although it can be selected as appropriate, it is preferably over 0.1, more preferably 1 or more, and particularly preferably 2.5 or more. The nutritional supplement composition within the preferred range tends to generate the unpleasant odor, but according to the present invention, the unpleasant odor can be suppressed.
前記(A)成分及び前記(B)成分の前記栄養補助組成物における合計含有量としては、特に制限はなく、目的に応じて適宜選択することができるが、前記栄養補助組成物100質量部に対して、4.9質量部以上が好ましく、10質量部以上がより好ましく、20質量部以上が特に好ましい。前記好ましい範囲内である前記栄養補助組成物は前記不快臭が発生しやすいが、本発明によれば、前記不快臭を抑制することができる。 The total content of the component (A) and the component (B) in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose; On the other hand, it is preferably 4.9 parts by mass or more, more preferably 10 parts by mass or more, and particularly preferably 20 parts by mass or more. Although the nutritional supplement composition falling within the preferable range tends to generate the unpleasant odor, according to the present invention, the unpleasant odor can be suppressed.
<(C)無機多孔質体>
前記無機多孔質体は、ビタミンB群から選択される少なくとも1種の化合物と、アミノ酸又はその塩とが共存することにより生じる不快臭を抑制するために配合される。
<(C) Inorganic porous body>
The inorganic porous material is blended to suppress unpleasant odor caused by the coexistence of at least one compound selected from the vitamin B group and an amino acid or a salt thereof.
前記無機多孔質体とは、微細な孔を多数有する無機材料のことをいう。前記無機多孔質体としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、ケイ酸塩、二酸化ケイ素、炭酸カルシウム、炭酸マグネシウム、不溶性鉱物性物質などが挙げられる。
前記不溶性鉱物性物質としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、酸性白土、カオリン、ベントナイト、タルク、砂、ケイソウ土、パーライトなどが挙げられる。
前記無機多孔質体は、1種単独で使用してもよいし、2種以上を併用してもよい。
前記無機多孔質体は、市販品を適宜使用することができる。
The inorganic porous body refers to an inorganic material having many fine pores. The inorganic porous material is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include silicates, silicon dioxide, calcium carbonate, magnesium carbonate, and insoluble mineral substances.
The insoluble mineral substance is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include acid clay, kaolin, bentonite, talc, sand, diatomaceous earth, and perlite.
The inorganic porous body may be used alone or in combination of two or more.
As the inorganic porous body, commercially available products can be used as appropriate.
前記無機多孔質体の中でも、前記不快臭の抑制効果がより優れる点で、ケイ酸塩が好ましい。
前記ケイ酸塩としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、ケイ酸カルシウム、ケイ酸マグネシウム、メタケイ酸アルミニウム、メタケイ酸アルミン酸マグネシウム、ケイ酸アルミン酸マグネシウムなどが挙げられる。これらは、1種単独で使用してもよいし、2種以上を併用してもよい。これらの中でも、一般食品に使用できる点で、ケイ酸カルシウムが好ましい。
Among the inorganic porous materials, silicates are preferred because they have a more excellent suppressing effect on the unpleasant odor.
The silicate is not particularly limited and can be appropriately selected depending on the purpose, such as calcium silicate, magnesium silicate, aluminum metasilicate, magnesium aluminate metasilicate, magnesium aluminate silicate, etc. Can be mentioned. These may be used alone or in combination of two or more. Among these, calcium silicate is preferred because it can be used in general foods.
前記ケイ酸カルシウムのメジアン径(d50)としては、特に制限はなく、目的に応じて適宜選択することができるが、1μm~200μmが好ましく、10μm~100μmがより好ましく、18μm~32μmが特に好ましい。
前記ケイ酸カルシウムのゆるみ嵩密度としては、特に制限はなく、目的に応じて適宜選択することができるが、0.04g/mL~0.30g/mLが好ましく、0.05g/mL~0.20g/mLがより好ましく、0.07g/mL~0.15g/mLが特に好ましい。
前記ケイ酸カルシウムの吸油量としては、特に制限はなく、目的に応じて適宜選択することができるが、300mL/100g~550mL/100gが好ましい。
前記メジアン径(d50)、ゆるみ嵩密度、及び吸油量を満たすケイ酸カルシウムとしては、例えば、下記式(1)で表されるケイ酸カルシウムが挙げられる。
2CaO・mSiO2・nH2O ・・・ 式(1)
ただし、前記式(1)中、1<m<2であり、2<n<3である。
前記ケイ酸カルシウムの市販品としては、例えば、フローライトR(富田製薬株式会社製)が挙げられる。
The median diameter (d50) of the calcium silicate is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 1 μm to 200 μm, more preferably 10 μm to 100 μm, and particularly preferably 18 μm to 32 μm.
The loose bulk density of the calcium silicate is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 0.04 g/mL to 0.30 g/mL, and 0.05 g/mL to 0.0 g/mL. 20 g/mL is more preferred, and 0.07 g/mL to 0.15 g/mL is particularly preferred.
The oil absorption amount of the calcium silicate is not particularly limited and can be appropriately selected depending on the purpose, but is preferably 300 mL/100 g to 550 mL/100 g.
Examples of the calcium silicate that satisfies the median diameter (d50), loose bulk density, and oil absorption include calcium silicate represented by the following formula (1).
2CaO・mSiO 2・nH 2 O... Formula (1)
However, in the formula (1), 1<m<2 and 2<n<3.
Examples of commercially available calcium silicate products include Fluorite R (manufactured by Tomita Pharmaceutical Co., Ltd.).
前記(C)成分の前記栄養補助組成物における含有量としては、特に制限はなく、目的に応じて適宜選択することができるが、前記栄養補助組成物100質量部に対して、前記(C)成分の合計量として、0.1質量部以上が好ましく、1質量部以上がより好ましく、3質量部~50質量部が特に好ましい。前記含有量が好ましい範囲内であると、前記不快臭の抑制効果がより優れる点で、有利である。 The content of the component (C) in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose; The total amount of the components is preferably 0.1 part by mass or more, more preferably 1 part by mass or more, and particularly preferably 3 parts by mass to 50 parts by mass. When the content is within a preferable range, it is advantageous in that the unpleasant odor suppressing effect is more excellent.
前記栄養補助組成物に含まれる前記無機多孔質体の各化合物の含有割合としては、特に制限はなく、目的に応じて適宜選択することができる。 The content ratio of each compound in the inorganic porous body contained in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose.
前記(C)成分と、前記(A)成分との質量比{(C)/(A)}としては、特に制限はなく、目的に応じて適宜選択することができるが、0.001~100が好ましく、0.01~50が好ましく、0.1~10が特に好ましい。前記質量比が好ましい範囲内であると、前記不快臭の抑制効果がより優れる点で、有利である。 The mass ratio of the component (C) to the component (A) {(C)/(A)} is not particularly limited and can be selected as appropriate depending on the purpose, but is 0.001 to 100. is preferable, 0.01 to 50 is preferable, and 0.1 to 10 is particularly preferable. When the mass ratio is within a preferable range, it is advantageous in that the unpleasant odor suppressing effect is more excellent.
<その他の成分>
前記栄養補助組成物におけるその他の成分としては、本発明の効果を損なわない限り、特に制限はなく、目的に応じて適宜選択することができ、例えば、ビタミンA、ビタミンC、ビタミンD、ビタミンE、ヘスペリジン、イノシトール等のビタミンB群以外のビタミン類;カゼイン分解物等の乳由来ペプチドを含有するペプチド含有物、鶏軟骨由来エキス等の動物由来ペプチドを含有するペプチド含有物、マカエキス、ゴマエキス等の植物由来ペプチドを含有するペプチド含有物、わかめエキス、こんぶエキス等の海藻由来ペプチドを含有するペプチド含有物、サメ軟骨抽出エキス、サケ鼻軟骨抽出エキス、マグロ抽出エキス等の魚類由来ペプチドを含有するペプチド含有物等のペプチド含有物;カルシウム、マグネシウム、亜鉛、鉄、マンガン、銅、セレン、クロム、モリブデン等のミネラル;コエンザイムQ10、α-リポ酸、L-カルニチン、コラーゲン、ヒアルロン酸、エラスチン、ウコン、グルコサミン、コンドロイチン等の機能性成分;各種ポリフェノール類;ステアリン酸、ステアリン酸カルシウム、ステアリン酸マグネシウム、フマル酸ステアリルナトリウム、ショ糖脂肪酸エステル、植物油脂、硬化油等の滑沢剤;部分α化デンプン、デンプングリコール酸ナトリウム等の崩壊剤;乳糖、ビール酵母、デキストリン、コーンスターチ等の賦形剤;プルラン、アラビアガム、キサンタンガム、グアーガム、アルギン酸等の天然多糖類;粉末セルロース;結晶セルロース;ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース等のセルロース誘導体;ポリビニルピロリドン、ポリビニルアルコール等の水溶性ポリマー;還元麦芽糖水あめ、キシリトール、ソルビトール、マンニトール、マルチトール等の糖アルコール;トレハロース、パラチノース、イソマルト等の二糖類;大豆多糖類;とうもろこしタンパク等の結合剤;固着剤;酸化チタン、酸化鉄等の着色剤;フィチン酸、クエン酸、コハク酸、クエン酸ナトリウム、酢酸ナトリウム、DL-リンゴ酸、リン酸、リン酸二ナトリウム等のpH調整剤又は緩衝剤;酸化防止剤などが挙げられる。これらは、1種単独で使用してもよいし、2種以上を併用してもよい。
前記その他の成分は、市販品を適宜使用することができる。
前記栄養補助組成物におけるその他の成分の含有量としては、特に制限はなく、目的に応じて適宜選択することができる。
<Other ingredients>
Other ingredients in the nutritional supplement composition are not particularly limited as long as they do not impair the effects of the present invention, and can be appropriately selected depending on the purpose, such as vitamin A, vitamin C, vitamin D, and vitamin E. , hesperidin, inositol, and other vitamins other than vitamin B group; peptide-containing products containing milk-derived peptides such as casein decomposition products; peptide-containing products containing animal-derived peptides such as chicken cartilage-derived extract; maca extract, sesame extract, etc. Peptide-containing products containing plant-derived peptides, peptide-containing products containing seaweed-derived peptides such as wakame extract and kelp extract, peptides containing fish-derived peptides such as shark cartilage extract, salmon nasal cartilage extract, and tuna extract. Peptide-containing substances such as minerals such as calcium, magnesium, zinc, iron, manganese, copper, selenium, chromium, and molybdenum; coenzyme Q10, α-lipoic acid, L-carnitine, collagen, hyaluronic acid, elastin, turmeric, Functional ingredients such as glucosamine and chondroitin; various polyphenols; lubricants such as stearic acid, calcium stearate, magnesium stearate, sodium stearyl fumarate, sucrose fatty acid ester, vegetable oil, and hydrogenated oil; partially pregelatinized starch, starch Disintegrants such as sodium glycolate; Excipients such as lactose, brewer's yeast, dextrin, corn starch; Natural polysaccharides such as pullulan, gum arabic, xanthan gum, guar gum, alginic acid; Powdered cellulose; Crystalline cellulose; Hydroxypropyl cellulose, hydroxypropyl Cellulose derivatives such as methylcellulose; Water-soluble polymers such as polyvinylpyrrolidone and polyvinyl alcohol; Sugar alcohols such as reduced maltose syrup, xylitol, sorbitol, mannitol, and maltitol; Disaccharides such as trehalose, palatinose, and isomalt; Soybean polysaccharides; Corn protein Binders such as; Fixing agents; Coloring agents such as titanium oxide and iron oxide; pH adjustment of phytic acid, citric acid, succinic acid, sodium citrate, sodium acetate, DL-malic acid, phosphoric acid, disodium phosphate, etc. agents or buffers; antioxidants, etc. These may be used alone or in combination of two or more.
For the other components mentioned above, commercially available products can be used as appropriate.
The content of other components in the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose.
前記栄養補助組成物の態様としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、前記(A)成分と、前記(B)成分と、前記(C)成分とを含む混合物の態様、前記(A)成分と前記(C)成分とを含む混合物としたものと、前記(B)成分とを含む混合物の態様、前記(B)成分と前記(C)成分とを含む混合物としたものと、前記(A)成分とを含む混合物の態様、前記(A)成分の少なくとも1種の化合物と前記(C)成分とを含む混合物としたものと、前記混合物に含まれる(A)成分を除く前記(A)成分の少なくとも1種の化合物と、前記(B)成分とを含む混合物の態様などが挙げられる。
これらの中でも、前記不快臭の抑制効果がより優れる点で、前記(A)成分と前記(C)成分とを含む混合物としたものと、前記(B)成分とを含む混合物の態様、前記(A)成分の少なくとも1種の化合物と前記(C)成分とを含む混合物としたものと、前記混合物に含まれる(A)成分を除く前記(A)成分の少なくとも1種の化合物と、前記(B)成分とを含む混合物の態様が好ましい。
前記態様における、「前記(A)成分と前記(C)成分とを含む混合物としたもの」、及び「前記(A)成分の少なくとも1種の化合物と前記(C)成分とを含む混合物としたもの」中の、前記(A)成分又は前記(A)成分の少なくとも1種の化合物は、ビタミンB1及びビタミンB6の少なくともいずれかであることが好ましく、ビタミンB1であることがより好ましい。
前記混合物は、顆粒であってもよいし、粉末であってもよい。
The form of the nutritional supplement composition is not particularly limited and can be selected as appropriate depending on the purpose, and includes, for example, the (A) component, the (B) component, and the (C) component. Embodiments of the mixture include a mixture containing the component (A) and the component (C), and an embodiment of the mixture containing the component (B), including the component (B) and the component (C). A mixture, a mixture containing the component (A), a mixture containing at least one compound of the component (A) and the component (C), and a mixture containing the component (C) contained in the mixture. Examples include embodiments of mixtures containing at least one compound of the component (A), excluding component A), and the component (B).
Among these, embodiments of a mixture containing the above-mentioned (A) component and the above-mentioned (C) component, a mixture containing the above-mentioned (B) component, and the above-mentioned ( A mixture containing at least one compound of component A) and the component (C), at least one compound of component (A) other than component (A) contained in the mixture, and A preferred embodiment is a mixture containing component B).
In the above embodiment, "a mixture containing the component (A) and the component (C)" and "a mixture containing at least one compound of the component (A) and the component (C)" The component (A) or at least one compound of the component (A) in the "product" is preferably at least one of vitamin B1 and vitamin B6, and more preferably vitamin B1.
The mixture may be in the form of granules or powder.
前記栄養補助組成物の形状としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、粉末、顆粒、錠剤などが挙げられる。
前記粉末、顆粒、及び錠剤の形状、構造、大きさとしては、特に制限はなく、目的に応じて適宜選択することができる。
The shape of the nutritional supplement composition is not particularly limited and can be appropriately selected depending on the purpose, such as powder, granules, and tablets.
The shape, structure, and size of the powder, granules, and tablets are not particularly limited and can be appropriately selected depending on the purpose.
前記栄養補助組成物は、栄養補助食品やサプリメントとして用いてもよいし、顆粒や錠剤の製造用原料として用いてもよい。 The nutritional supplement composition may be used as a nutritional supplement or supplement, or as a raw material for manufacturing granules or tablets.
本発明によれば、前記栄養補助組成物に含まれる栄養素の生理活性機能を害することなく、保管中、特に、夏場のような高温・多湿の環境下での保管中に生じる不快臭を低減することができる。
また、本発明の栄養補助組成物は、後述する本発明の栄養補助組成物の製造方法により好適に製造することができ、製造コスト面でも優れる。
According to the present invention, unpleasant odors that occur during storage, particularly during storage in a high temperature and humid environment such as in summer, can be reduced without impairing the physiologically active functions of nutrients contained in the nutritional supplement composition. be able to.
Moreover, the nutritional supplement composition of the present invention can be suitably manufactured by the method for manufacturing a nutritional supplement composition of the present invention described below, and is excellent in terms of manufacturing cost.
(栄養補助組成物の製造方法)
本発明の栄養補助組成物の製造方法は、混合工程を少なくとも含み、必要に応じて更にその他の工程を含む。
(Method for producing nutritional supplement composition)
The method for producing a nutritional supplement composition of the present invention includes at least a mixing step, and further includes other steps as necessary.
<混合工程>
前記混合工程は、(A)ビタミンB群から選択される少なくとも1種の化合物と、(B)アミノ酸又はその塩と、(C)無機多孔質体とを混合する工程である。前記混合工程では、必要に応じて更にその他の成分を混合してもよい。
<Mixing process>
The mixing step is a step of mixing (A) at least one compound selected from the vitamin B group, (B) an amino acid or a salt thereof, and (C) an inorganic porous body. In the mixing step, other components may be further mixed as necessary.
前記混合工程における、前記(A)成分、前記(B)成分、前記(C)成分、及び前記その他の成分は、上記した本発明の(栄養補助組成物)の項目に記載したものと同様であり、好ましい態様も同様である。 In the mixing step, the (A) component, the (B) component, the (C) component, and the other components are the same as those described in the item (nutritional supplement composition) of the present invention above. The same applies to preferred embodiments.
前記混合工程は、前記(A)成分と、前記(B)成分と、前記(C)成分と、必要に応じて前記その他の成分とを1回でまとめて混合してもよいし、任意の成分ごとに複数回に分けて混合してもよい。 In the mixing step, the (A) component, the (B) component, the (C) component, and if necessary, the other components may be mixed all at once, or any combination of Each component may be mixed in multiple batches.
前記混合工程は、前記(A)成分と、前記(C)成分とを混合する第1の混合処理と、前記第1の混合処理で得られた混合物と、前記(B)成分とを混合する第2の混合処理とを含む態様が好ましい。前記好ましい態様であると、(A)成分と、(B)成分とが共存することにより生じる不快臭をより抑制することができる点で、有利である。
前記各混合処理では、上記した以外の成分を必要に応じて混合してもよい。
The mixing step includes a first mixing process of mixing the (A) component and the (C) component, and mixing the mixture obtained in the first mixing process and the (B) component. An embodiment including a second mixing treatment is preferred. The preferred embodiment is advantageous in that the unpleasant odor caused by the coexistence of component (A) and component (B) can be further suppressed.
In each of the mixing processes described above, components other than those mentioned above may be mixed as necessary.
前記混合工程における前記混合物は、粉末であってもよいし、造粒した顆粒であってもよい。
前記混合工程により、粉末又は顆粒の形状の栄養補助組成物とすることができる。
The mixture in the mixing step may be a powder or a granulated granule.
The mixing step allows the nutritional supplement composition to be in the form of powder or granules.
前記混合は公知の装置を用いて行うことができ、該装置としては、例えば、コンテナタンブラー、V型混合機、ボーレ コンテナミキサーなどが挙げられる。
前記混合の温度、時間等の条件としては、特に制限はなく、適宜選択することができる。
The mixing can be carried out using a known device, such as a container tumbler, a V-type mixer, a Bohle container mixer, and the like.
Conditions such as temperature and time for the mixing are not particularly limited and can be selected as appropriate.
前記造粒の方法としては、特に制限はなく、公知の方法を適宜選択することができ、例えば、流動層造粒法、攪拌造粒法、乾式造粒法などが挙げられる。
前記造粒の方法の具体例としては、前記各成分を練合、捏和、及び/又は攪拌し、適宜選択した結合剤を噴霧する方法が挙げられる。
The granulation method is not particularly limited, and any known method can be selected as appropriate, and examples thereof include fluidized bed granulation, agitation granulation, and dry granulation.
A specific example of the granulation method includes a method of kneading, kneading, and/or stirring the respective components, and then spraying an appropriately selected binder.
前記結合剤としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、ヒドロキシプロピルメチルセルロース、ヒドロキシプロピルセルロース、メチルセルロース等のセルロース誘導体、プルラン、グアーガム等の増粘多糖類、イソマルトース、キシリトール、マルチトール、ソルビトール等の糖アルコールなどが挙げられる。これらは、1種単独で使用してもよいし、2種以上を併用してもよい。
前記結合剤は、市販品を適宜使用することができる。
The binder is not particularly limited and can be appropriately selected depending on the purpose, such as cellulose derivatives such as hydroxypropylmethylcellulose, hydroxypropylcellulose, and methylcellulose, thickening polysaccharides such as pullulan and guar gum, and isomaltose. , sugar alcohols such as xylitol, maltitol, and sorbitol. These may be used alone or in combination of two or more.
As the binder, commercially available products can be used as appropriate.
前記結合剤は、噴霧するために、溶解液乃至分散液(以下、「噴霧液」と称することがある。)とすることが好ましい。
前記結合剤を溶解乃至分散するために用いる溶媒としては、特に制限はなく、使用する結合剤の種類などに応じて適宜選択することができ、例えば、水、エタノール、これらの混合溶媒などが挙げられる。
The binder is preferably in the form of a solution or dispersion (hereinafter sometimes referred to as a "spray liquid") in order to be sprayed.
The solvent used for dissolving or dispersing the binder is not particularly limited and can be appropriately selected depending on the type of binder used, for example, water, ethanol, a mixed solvent thereof, etc. It will be done.
前記噴霧液の粘度、噴霧液中の結合剤の濃度(固形分濃度)としては、特に制限はなく、目的に応じて適宜選択することができる。
前記噴霧液を噴霧する方法としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、使用する造粒装置に設けられた噴霧手段、例えば、スプレーガン、噴霧ノズル等から噴霧する方法などが挙げられる。
前記噴霧の条件(噴霧量、噴霧する霧粒子(ミスト)の大きさ、噴霧時間、噴霧間隔等)としては、特に制限はなく、公知の条件を適宜選択することができる。
The viscosity of the spray liquid and the concentration of the binder (solid content concentration) in the spray liquid are not particularly limited and can be appropriately selected depending on the purpose.
The method of spraying the spray liquid is not particularly limited and can be selected as appropriate depending on the purpose. Examples include methods to do so.
The spraying conditions (spray amount, size of sprayed mist particles, spray time, spray interval, etc.) are not particularly limited, and known conditions can be appropriately selected.
前記造粒は公知の装置を用いて行うことができ、該装置としては、例えば、噴霧造粒装置、流動層造粒装置、撹拌造粒装置などが挙げられる。
前記造粒の温度、時間等の条件としては、特に制限はなく、目的に応じて適宜選択することができる。
The granulation can be carried out using a known device, and examples of the device include a spray granulator, a fluidized bed granulator, and an agitation granulator.
Conditions such as temperature and time for the granulation are not particularly limited and can be appropriately selected depending on the purpose.
<その他の工程>
前記その他の工程としては、本発明の効果を損なわない限り、特に制限はなく、目的に応じて適宜選択することができ、例えば、打錠工程などが挙げられる。
<Other processes>
The other steps are not particularly limited as long as they do not impair the effects of the present invention, and can be appropriately selected depending on the purpose, and include, for example, a tableting step.
前記打錠工程は、前記混合工程で得られた粉末又は顆粒と、必要に応じて前記その他の成分とを混合した打錠末を打錠する工程であり、これにより、錠剤の形状の栄養補助組成物とすることができる。 The tableting step is a step of compressing a tablet powder obtained by mixing the powder or granules obtained in the mixing step with the other ingredients as necessary, and thereby forms a nutritional supplement in the form of a tablet. It can be a composition.
前記打錠は公知の装置を用いて行うことができ、該装置としては、例えば、打錠機(例えば、HT-APSS型、HT-AP-MS型、HT-X-SS型、HT-X-MS型(以上、株式会社畑鉄工所製);VEL5、VIRGO、AQUARIUS、LIBRA(以上、株式会社菊水製作所製))などが挙げられる。 The tableting can be performed using a known device, such as a tableting machine (for example, HT-APSS model, HT-AP-MS model, HT-X-SS model, HT-X - MS type (manufactured by Hata Tekkosho Co., Ltd.); VEL5, VIRGO, AQUARIUS, LIBRA (manufactured by Kikusui Seisakusho Co., Ltd.), etc.
前記打錠における打錠圧等の条件としては、特に制限はなく、目的に応じて適宜選択することができる。 Conditions such as the tableting pressure in the tableting are not particularly limited and can be appropriately selected depending on the purpose.
本発明の栄養補助組成物の製造方法によれば、保管中、特に、夏場のような高温・多湿の環境下で保管中に生じる不快臭を低減することができる栄養補助組成物を効率良く製造することができる。 According to the method for producing a nutritional supplement composition of the present invention, a nutritional supplement composition can be efficiently produced that can reduce unpleasant odors that occur during storage, especially during storage in high temperature and humid environments such as in summer. can do.
(不快臭の抑制方法)
本発明の不快臭の抑制方法は、(A)ビタミンB群から選択される少なくとも1種の化合物と、(B)アミノ酸又はその塩とを含有する栄養補助組成物の不快臭の抑制方法であって、混合工程を少なくとも含み、必要に応じて更にその他の工程を含む。
(Method for suppressing unpleasant odor)
The method for suppressing unpleasant odor of the present invention is a method for suppressing unpleasant odor of a nutritional supplement composition containing (A) at least one compound selected from the vitamin B group and (B) an amino acid or a salt thereof. The method includes at least a mixing step, and further includes other steps as necessary.
<混合工程>
前記混合工程は、(A)ビタミンB群から選択される少なくとも1種の化合物と、(B)アミノ酸又はその塩と、(C)無機多孔質体とを混合する工程であり、上記した本発明の(栄養補助組成物の製造方法)の<混合工程>の項目に記載したものと同様にして行うことができ、好ましい態様も同様とすることができる。
<Mixing process>
The mixing step is a step of mixing (A) at least one compound selected from the vitamin B group, (B) an amino acid or a salt thereof, and (C) an inorganic porous body, and the above-described present invention It can be carried out in the same manner as described in the <Mixing step> section of (Method for producing a nutritional supplement composition), and the preferred embodiments can also be the same.
<その他の工程>
前記その他の工程としては、本発明の効果を損なわない限り、特に制限はなく、目的に応じて適宜選択することができ、例えば、上記した本発明の(栄養補助組成物の製造方法)の<その他の工程>の項目に記載したものと同様のものが挙げられる。
<Other processes>
The other steps described above are not particularly limited and can be appropriately selected depending on the purpose as long as they do not impair the effects of the present invention. The same methods as those described in the section ``Other steps'' can be mentioned.
本発明の不快臭の抑制方法によれば、栄養補助組成物の保管中、特に、夏場のような高温・多湿の環境下で保管中に生じる不快臭を低減することができる。 According to the method for suppressing unpleasant odors of the present invention, it is possible to reduce unpleasant odors that occur during storage of a nutritional supplement composition, particularly during storage in a high temperature and humid environment such as in summer.
(不快臭抑制用組成物)
本発明の不快臭抑制用組成物は、ビタミンB群から選択される少なくとも1種の化合物と、アミノ酸又はその塩とを含有する栄養補助組成物の不快臭を抑制するために用いられ、無機多孔質体を少なくとも含み、必要に応じて更にその他の成分を含む。
(Composition for suppressing unpleasant odor)
The unpleasant odor suppressing composition of the present invention is used to suppress the unpleasant odor of a nutritional supplement composition containing at least one compound selected from the vitamin B group and an amino acid or a salt thereof. It contains at least a substance, and further contains other components as necessary.
<無機多孔質体>
前記無機多孔質体は、上記した本発明の(栄養補助組成物)の<無機多孔質体>の項目に記載したものと同様であり、好ましい態様も同様である。
<Inorganic porous body>
The inorganic porous body is the same as that described in the item <Inorganic porous body> of the above-described (nutritional supplement composition) of the present invention, and the preferred embodiments are also the same.
前記無機多孔質体の前記不快臭抑制用組成物における含有量としては、特に制限はなく、目的に応じて適宜選択することができる。前記不快臭抑制用組成物は、前記無機多孔質体のみからなるものであってもよい。 The content of the inorganic porous material in the unpleasant odor suppressing composition is not particularly limited and can be appropriately selected depending on the purpose. The unpleasant odor suppressing composition may consist only of the inorganic porous material.
<その他の成分>
前記その他の成分としては、特に制限はなく、目的に応じて適宜選択することができ、例えば、上記した本発明の(栄養補助組成物)の<その他の成分>の項目に記載したものと同様のものが挙げられる。
<Other ingredients>
The other ingredients are not particularly limited and can be selected as appropriate depending on the purpose, for example, the same as those described in the <Other ingredients> section of the (nutritional supplement composition) of the present invention above. Examples include:
前記不快臭抑制用組成物によれば、ビタミンB群から選択される少なくとも1種の化合物と、アミノ酸又はその塩とを含有する栄養補助組成物の保管中、特に、夏場のような高温・多湿の環境下で保管中に生じる不快臭を低減することができる。 According to the composition for suppressing unpleasant odor, during storage of the nutritional supplement composition containing at least one compound selected from the vitamin B group and an amino acid or a salt thereof, the composition may be stored at high temperatures and high humidity such as in summer. It is possible to reduce unpleasant odors that occur during storage in such environments.
以下に試験例を挙げて本発明を具体的に説明するが、本発明はこれらの試験例に何ら限定されるものではない。 The present invention will be specifically explained below with reference to test examples, but the present invention is not limited to these test examples.
(試験例1-1)
ポリエチレン袋中で、下記表1-1に記載した量の各種ビタミンと、ロイシンとを混合した後、水を1g添加して混合し、混合物を得た。
前記混合物を含むポリエチレン袋を密封し、60℃の恒温槽に1日間静置した後、発生する不快臭に対する官能評価を以下のようにして実施した。なお、前記不快臭は、原料自体の臭いではなく、前記静置後に発生した臭いのことをいう(以下同様)。評価は3名で行い、その平均値を下記表1-1に示した。
-官能評価-
3点 : 不快な臭いが強い。
2点 : 不快な臭いがする。
1点 : 不快な臭いがややする。
0点 : 不快な臭いはしない。
なお、使用したビタミンの詳細は、以下の通りである。
・ ビタミンA(ドライビタミンAアセテート32.6万IU/g、BASFジャパン株式会社製、以下同様)
・ ビタミンB1(ビタミンB1硝酸塩、BASFジャパン株式会社製、以下同様)
・ ビタミンB2(リボフラビンFP、BASFジャパン株式会社製、以下同様)
・ ビタミンB6(ピリドキシン塩酸塩、BASFジャパン株式会社製、以下同様)
・ ビタミンC(アスコルビン酸100M、BASFジャパン株式会社製、以下同様)
・ ビタミンD(ドライビタミンD3、三菱ケミカルフーズ株式会社製、以下同様)
・ ビタミンE(理研ドライEミックスF-20S、理研ビタミン株式会社製、以下同様)
(Test example 1-1)
After mixing various vitamins and leucine in the amounts listed in Table 1-1 below in a polyethylene bag, 1 g of water was added and mixed to obtain a mixture.
After the polyethylene bag containing the mixture was sealed and allowed to stand in a constant temperature bath at 60° C. for one day, a sensory evaluation of the unpleasant odor generated was performed as follows. Note that the unpleasant odor refers not to the odor of the raw material itself, but to the odor generated after the raw material is left standing (the same applies hereinafter). The evaluation was performed by three people, and the average value is shown in Table 1-1 below.
-sensory evaluation-
3 points: Strong unpleasant odor.
2 points: There is an unpleasant odor.
1 point: Slightly unpleasant odor.
0 points: No unpleasant odor.
The details of the vitamins used are as follows.
- Vitamin A (dry vitamin A acetate 326,000 IU/g, manufactured by BASF Japan Co., Ltd., hereinafter the same)
・ Vitamin B1 (vitamin B1 nitrate, manufactured by BASF Japan Co., Ltd., hereinafter the same)
・ Vitamin B2 (riboflavin FP, manufactured by BASF Japan Co., Ltd., the same hereinafter)
- Vitamin B6 (pyridoxine hydrochloride, manufactured by BASF Japan Co., Ltd., hereinafter the same)
・ Vitamin C (ascorbic acid 100M, manufactured by BASF Japan Co., Ltd., hereinafter the same)
・Vitamin D (dry vitamin D3, manufactured by Mitsubishi Chemical Foods Co., Ltd., hereinafter the same)
・ Vitamin E (Riken Dry E Mix F-20S, manufactured by Riken Vitamin Co., Ltd., hereinafter the same)
表1-1の結果から、ビタミンB群の化合物と、ロイシンとが共存する場合に、不快臭が生じることが確認された。 From the results shown in Table 1-1, it was confirmed that an unpleasant odor occurs when a compound of the vitamin B group and leucine coexist.
(試験例1-2)
ポリエチレン袋中で、下記表1-2に記載した量のビタミンB群の化合物と、ロイシンとを混合した後、下記表1-2に記載した量の水を添加して混合し、混合物を得た。
前記混合物を含むポリエチレン袋を密封し、60℃の恒温槽に1日間静置した後、発生する不快臭に対する官能評価を以下のようにして実施した。
[官能評価]
試験例1-2-1の不快臭を10点(コントロール)とし、不快臭の強さに応じて0点(不快臭がしない)~10点(不快臭が強い)の11段階で評価した。評価は3名で行い、その平均値を下記表1-2に示した。
(Test example 1-2)
In a polyethylene bag, mix the vitamin B group compounds and leucine in the amounts listed in Table 1-2 below, then add and mix the amounts of water listed in Table 1-2 below to obtain a mixture. Ta.
After the polyethylene bag containing the mixture was sealed and allowed to stand in a constant temperature bath at 60° C. for one day, a sensory evaluation of the unpleasant odor generated was performed as follows.
[sensory evaluation]
The unpleasant odor of Test Example 1-2-1 was given a score of 10 (control), and was evaluated on an 11-point scale from 0 (no unpleasant odor) to 10 (strong unpleasant odor) depending on the intensity of the unpleasant odor. The evaluation was performed by three people, and the average value is shown in Table 1-2 below.
表1-2の結果から、ビタミンB群の化合物と、ロイシンとの質量比を変えた場合でも、不快臭が生じることが確認され、特に前記質量比{(A)成分/(B)成分}が0.1超の場合に顕著に強くなることが確認された。 From the results in Table 1-2, it was confirmed that an unpleasant odor occurs even when the mass ratio of vitamin B group compounds to leucine is changed, and especially when the mass ratio {(A) component/(B) component} It was confirmed that the strength becomes significantly stronger when the value exceeds 0.1.
(試験例2)
<試験例2-1>
-顆粒の調製-
撹拌混合造粒装置(VGmm、株式会社パウレック製)にて、下記表2-1に記載した量のビタミンB1と、各種無機多孔質体とを混合した後、下記表2-1に記載した量の水を滴下して顆粒状になるまで造粒し、造粒物を得た。
前記造粒物を乾燥させ(棚乾燥、60℃)、16メッシュ篩にて篩過し、各顆粒サンプルとした。
なお、使用した無機多孔質体の詳細は、以下の通りである。
・ ケイ酸カルシウム(フローライトR、富田製薬株式会社製、以下同様)
・ 二酸化ケイ素(AEROSILR 200 FAD、日本アエロジル株式会社製、以下同様)
・ 炭酸カルシウム(未焼成ホタテ末、株式会社エヌ・シー・コーポレーション製、以下同様)
(Test example 2)
<Test Example 2-1>
-Preparation of granules-
After mixing vitamin B1 in the amount listed in Table 2-1 below and various inorganic porous materials in a stirring mixing granulation device (VGmm, manufactured by Powrex Co., Ltd.), the amounts listed in Table 2-1 below are mixed. of water was added dropwise to the mixture, and the mixture was granulated to obtain a granulated product.
The granules were dried (shelf drying, 60° C.) and sieved through a 16 mesh sieve to obtain each granule sample.
The details of the inorganic porous material used are as follows.
- Calcium silicate (Fluorite R, manufactured by Tomita Pharmaceutical Co., Ltd., hereinafter the same)
・Silicon dioxide (AEROSILR 200 FAD, manufactured by Nippon Aerosil Co., Ltd., hereinafter the same)
・ Calcium carbonate (unbaked scallop powder, manufactured by NC Corporation, hereinafter the same)
-混合物の調製・評価-
ポリエチレン袋中で、下記表2-2に記載した量の、前記各顆粒サンプル又はビタミンB1と、ロイシンと、ビタミンB6とを混合した後、下記表2-2に記載した量の水を滴下しながら混合し、混合物を得た。
前記混合物を含むポリエチレン袋を密封し、60℃の恒温槽に1日間静置した後、発生する不快臭に対する官能評価を以下のようにして実施した。
[官能評価]
試験例2-1-1の不快臭を10点(コントロール)とし、不快臭の強さに応じて0点(不快臭がしない)~10点(不快臭が強い)の11段階で評価した。評価は6名で行い、その平均値を下記表2-2に示した。
-Preparation and evaluation of mixtures-
After mixing each of the granule samples or vitamin B1, leucine, and vitamin B6 in the amounts listed in Table 2-2 below in a polyethylene bag, drop the amount of water listed in Table 2-2 below. A mixture was obtained.
After the polyethylene bag containing the mixture was sealed and allowed to stand in a constant temperature bath at 60° C. for one day, a sensory evaluation of the unpleasant odor generated was performed as follows.
[sensory evaluation]
The unpleasant odor of Test Example 2-1-1 was given a score of 10 (control), and was evaluated on an 11-point scale from 0 (no unpleasant odor) to 10 (strong unpleasant odor) depending on the intensity of the unpleasant odor. The evaluation was conducted by six people, and the average value is shown in Table 2-2 below.
<試験例2-2>
-顆粒の調製-
--試験例2-2-2、2-2-3、2-2-7、2-2-8--
撹拌混合造粒装置(VGmm、株式会社パウレック製)にて、下記表2-3に記載した量の水以外の成分を混合した後、下記表2-3に記載した量の水を滴下して顆粒状になるまで造粒し、造粒物を得た。
前記造粒物を乾燥させ(棚乾燥、60℃)、16メッシュ篩にて篩過し、各顆粒サンプルとした。
<Test Example 2-2>
-Preparation of granules-
--Test examples 2-2-2, 2-2-3, 2-2-7, 2-2-8--
After mixing the ingredients other than water in the amounts listed in Table 2-3 below using a stirring mixing granulator (VGmm, manufactured by Powrex Co., Ltd.), add dropwise the amounts of water listed in Table 2-3 below. Granules were obtained by granulation until they became granules.
The granules were dried (shelf drying, 60° C.) and sieved through a 16 mesh sieve to obtain each granule sample.
--試験例2-2-4--
下記表2-3に記載した量のビタミンB1と、ヒドロキシプロピルメチルセルロース(以下、「HPMC」と称することがある。)とを水30gに溶解した後、下記表2-3に記載した量のケイ酸カルシウムと混合して顆粒状になるまで造粒し、造粒物を得た。
前記造粒物を乾燥させ(棚乾燥、60℃)、16メッシュ篩にて篩過し、顆粒サンプルとした。
--Test example 2-2-4--
After dissolving vitamin B1 in the amount listed in Table 2-3 below and hydroxypropyl methylcellulose (hereinafter sometimes referred to as "HPMC") in 30 g of water, dissolve the amount of silica in the amount listed in Table 2-3 below. The mixture was mixed with calcium acid and granulated into granules to obtain a granulated product.
The granules were dried (shelf drying, 60° C.) and sieved through a 16 mesh sieve to obtain granule samples.
--試験例2-2-5--
下記表2-3に記載した量のビタミンB1を水20gに溶解した後、下記表2-3に記載した量のケイ酸カルシウムと混合し、次いで、水10gに溶解したHPMCを更に添加・混合して顆粒状になるまで造粒し、造粒物を得た。
前記造粒物を乾燥させ(棚乾燥、60℃)、16メッシュ篩にて篩過し、顆粒サンプルとした。
--Test example 2-2-5--
After dissolving the amount of vitamin B1 listed in Table 2-3 below in 20 g of water, mixing with calcium silicate in the amount listed in Table 2-3 below, then further adding and mixing HPMC dissolved in 10 g of water. The mixture was granulated into granules to obtain a granulated product.
The granules were dried (shelf drying, 60° C.) and sieved through a 16 mesh sieve to obtain granule samples.
--試験例2-2-6--
下記表2-3に記載した量のビタミンB1を水30gに溶解した後、下記表2-3に記載した量のケイ酸カルシウムと混合し、次いで、HPMC(粉末)を更に添加・混合して顆粒状になるまで造粒し、造粒物を得た。
前記造粒物を乾燥させ(棚乾燥、60℃)、16メッシュ篩にて篩過し、顆粒サンプルとした。
--Test example 2-2-6--
After dissolving vitamin B1 in the amount listed in Table 2-3 below in 30 g of water, it was mixed with calcium silicate in the amount listed in Table 2-3 below, and then HPMC (powder) was further added and mixed. Granules were obtained by granulation until they became granules.
The granules were dried (shelf drying, 60° C.) and sieved through a 16 mesh sieve to obtain granule samples.
なお、使用した各成分の詳細は、以下の通りである。
・ フィチン酸(液体)(フィチン酸(50%水溶液)、築野ライスファインケミカルズ株式会社製、以下同様)
・ ヒドロキシプロピルメチルセルロース(メトローズ SE-06、信越化学工業株式会社製、以下同様)
・ プルラン(プルラン、株式会社林原製、以下同様)
・ デキストリン(パインデックス#100、松谷化学株式会社製、以下同様)
The details of each component used are as follows.
・Phytic acid (liquid) (phytic acid (50% aqueous solution), manufactured by Tsukino Rice Fine Chemicals Co., Ltd., hereinafter the same)
・Hydroxypropyl methylcellulose (Metrose SE-06, manufactured by Shin-Etsu Chemical Co., Ltd., hereinafter the same)
・ Pullulan (Pullulan, manufactured by Hayashibara Co., Ltd., hereinafter the same)
・Dextrin (Paindex #100, manufactured by Matsutani Chemical Co., Ltd., the same applies hereinafter)
-混合物の調製・評価-
ポリエチレン袋中で、下記表2-4に記載した量の、前記各顆粒サンプル又はビタミンB1と、ロイシンと、ビタミンB6とを混合した後、下記表2-4に記載した量の水を滴下しながら混合し、混合物を得た。
前記混合物を含むポリエチレン袋を密封し、60℃の恒温槽に1日間静置した後、発生する不快臭に対する官能評価を以下のようにして実施した。
[官能評価]
試験例2-2-1の不快臭を10点(コントロール)とし、不快臭の強さに応じて0点(不快臭がしない)~10点(不快臭が強い)の11段階で評価した。評価は5名で行い、その平均値を下記表2-4に示した。
-Preparation and evaluation of mixtures-
In a polyethylene bag, mix each of the above granule samples or vitamin B1, leucine, and vitamin B6 in the amounts listed in Table 2-4 below, then dropwise add water in the amounts listed in Table 2-4 below. A mixture was obtained.
After the polyethylene bag containing the mixture was sealed and allowed to stand in a constant temperature bath at 60° C. for one day, a sensory evaluation of the unpleasant odor generated was performed as follows.
[sensory evaluation]
The unpleasant odor of Test Example 2-2-1 was given a score of 10 (control), and was evaluated on an 11-point scale from 0 (no unpleasant odor) to 10 (strong unpleasant odor) depending on the intensity of the unpleasant odor. The evaluation was performed by five people, and the average value is shown in Table 2-4 below.
試験例2の結果から、無機多孔質体を用いることで、ビタミンB群の化合物と、アミノ酸とが共存する場合に生じる不快臭を抑制できることが確認された。また、無機多孔質体の中でもケイ酸塩であるケイ酸カルシウムが不快臭の抑制効果がより優れること、結合剤等の他の成分が含まれていても、無機多孔質体を用いることで、前記不快臭を抑制できることも確認された。 From the results of Test Example 2, it was confirmed that by using the inorganic porous material, it was possible to suppress the unpleasant odor that occurs when a vitamin B group compound and an amino acid coexist. In addition, among inorganic porous materials, calcium silicate, which is a silicate, is more effective in suppressing unpleasant odors, and even if other components such as binders are included, by using an inorganic porous material, It was also confirmed that the unpleasant odor could be suppressed.
(試験例3)
<試験例3-1>
-顆粒の調製-
撹拌混合造粒装置(VGmm、株式会社パウレック製)にて、下記表3-1に記載した量のビタミンB1と、ケイ酸カルシウムとを混合した後、下記表3-1に記載した量の水を滴下して顆粒状になるまで造粒し、造粒物を得た。
前記造粒物を乾燥させ(棚乾燥、60℃)、16メッシュ篩にて篩過し、各顆粒サンプルとした。
(Test example 3)
<Test Example 3-1>
-Preparation of granules-
After mixing vitamin B1 and calcium silicate in the amounts listed in Table 3-1 below using a stirring mixing granulator (VGmm, manufactured by Powrec Co., Ltd.), add water in the amount listed in Table 3-1 below. was added dropwise and granulated until it became granules to obtain a granulated product.
The granules were dried (shelf drying, 60° C.) and sieved through a 16 mesh sieve to obtain each granule sample.
-混合物の調製・評価-
ポリエチレン袋中で、下記表3-2に記載した量の、前記各顆粒サンプル又はビタミンB1と、ロイシンと、ビタミンB6とを混合した後、下記表3-2に記載した量の水を滴下しながら混合し、混合物を得た。
前記混合物を含むポリエチレン袋を密封し、60℃の恒温槽に1日間静置した後、発生する不快臭に対する官能評価を以下のようにして実施した。
[官能評価]
試験例3-1-1の不快臭を10点(コントロール)とし、不快臭の強さに応じて0点(不快臭がしない)~10点(不快臭が強い)の11段階で評価した。評価は3名で行い、その平均値を下記表3-2に示した。
-Preparation and evaluation of mixtures-
In a polyethylene bag, mix each of the granule samples or vitamin B1, leucine, and vitamin B6 in the amounts listed in Table 3-2 below, then drop the amount of water listed in Table 3-2 below. A mixture was obtained.
After the polyethylene bag containing the mixture was sealed and allowed to stand in a constant temperature bath at 60° C. for one day, a sensory evaluation of the unpleasant odor generated was performed as follows.
[sensory evaluation]
The unpleasant odor of Test Example 3-1-1 was given a score of 10 (control), and was evaluated on an 11-point scale from 0 (no unpleasant odor) to 10 (strong unpleasant odor) depending on the intensity of the unpleasant odor. The evaluation was performed by three people, and the average value is shown in Table 3-2 below.
<試験例3-2>
-顆粒の調製-
撹拌混合造粒装置(VGmm、株式会社パウレック製)にて、下記表3-3に記載した量のビタミンB1と、ケイ酸カルシウムとを混合した後、下記表3-3に記載した量の水を滴下して顆粒状になるまで造粒し、造粒物を得た。
前記造粒物を乾燥させ(棚乾燥、60℃)、16メッシュ篩にて篩過し、各顆粒サンプルとした。
<Test Example 3-2>
-Preparation of granules-
After mixing vitamin B1 and calcium silicate in the amounts listed in Table 3-3 below using a stirring mixing granulator (VGmm, manufactured by Powrex Co., Ltd.), add water in the amount listed in Table 3-3 below. was added dropwise and granulated until it became granules to obtain a granulated product.
The granules were dried (shelf drying, 60° C.) and sieved through a 16 mesh sieve to obtain each granule sample.
-混合物の調製・評価-
ポリエチレン袋中で、下記表3-4に記載した量の、前記各顆粒サンプル又はビタミンB1と、ロイシンと、ビタミンB6とを混合した後、下記表3-4に記載した量の水を滴下しながら混合し、混合物を得た。
前記混合物を含むポリエチレン袋を密封し、60℃の恒温槽に1日間静置した後、発生する不快臭に対する官能評価を以下のようにして実施した。
[官能評価]
試験例3-2-1の不快臭を10点(コントロール)とし、不快臭の強さに応じて0点(不快臭がしない)~10点(不快臭が強い)の11段階で評価した。評価は6名で行い、その平均値を下記表3-4に示した。
-Preparation and evaluation of mixtures-
In a polyethylene bag, mix each of the granule samples or vitamin B1, leucine, and vitamin B6 in the amounts listed in Table 3-4 below, then dropwise add water in the amount listed in Table 3-4 below. A mixture was obtained.
After the polyethylene bag containing the mixture was sealed and allowed to stand in a constant temperature bath at 60° C. for one day, a sensory evaluation of the unpleasant odor generated was performed as follows.
[sensory evaluation]
The unpleasant odor of Test Example 3-2-1 was given a score of 10 (control), and was evaluated on an 11-point scale from 0 (no unpleasant odor) to 10 (strong unpleasant odor) depending on the intensity of the unpleasant odor. The evaluation was conducted by six people, and the average value is shown in Table 3-4 below.
試験例3の結果から、無機多孔質体と、ビタミンB群の化合物との質量比率を変えた場合でも、ビタミンB群の化合物とアミノ酸とが共存する場合に生じる不快臭を抑制できることが確認された。 From the results of Test Example 3, it was confirmed that even if the mass ratio of the inorganic porous material and the vitamin B group compound was changed, the unpleasant odor that occurs when the vitamin B group compound and the amino acid coexist can be suppressed. Ta.
(試験例4)
<試験例4-1>
-顆粒の調製-
撹拌混合造粒装置(VGmm、株式会社パウレック製)にて、下記表4-1に記載した量のビタミンB6又はロイシンと、ケイ酸カルシウムとを混合した後、下記表4-1に記載した量の水を滴下して顆粒状になるまで造粒し、造粒物を得た。
前記造粒物を乾燥させ(棚乾燥、60℃)、16メッシュ篩にて篩過し、各顆粒サンプルとした。
(Test example 4)
<Test Example 4-1>
-Preparation of granules-
After mixing vitamin B6 or leucine in the amount listed in Table 4-1 below and calcium silicate in a stirring mixing granulation device (VGmm, manufactured by Powrex Co., Ltd.), add the amount listed in Table 4-1 below. of water was added dropwise to the mixture, and the mixture was granulated to obtain a granulated product.
The granules were dried (shelf drying, 60° C.) and sieved through a 16 mesh sieve to obtain each granule sample.
-混合物の調製・評価-
ポリエチレン袋中で、下記表4-2に記載した量の、ビタミンB1と、ビタミンB6又は前記顆粒サンプルと、ロイシン又は前記顆粒サンプルとを混合した後、下記表4-2に記載した量の水を滴下しながら混合し、混合物を得た。
前記混合物を含むポリエチレン袋を密封し、60℃の恒温槽に1日間静置した後、発生する不快臭に対する官能評価を以下のようにして実施した。
[官能評価]
試験例4-1-1の不快臭を10点(コントロール)とし、不快臭の強さに応じて0点(不快臭がしない)~10点(不快臭が強い)の11段階で評価した。評価は3名で行い、その平均値を下記表4-2に示した。
-Preparation and evaluation of mixtures-
After mixing vitamin B1, vitamin B6 or the granule sample, and leucine or the granule sample in the amounts listed in Table 4-2 below in a polyethylene bag, add water in the amount listed in Table 4-2 below. was added dropwise to obtain a mixture.
After the polyethylene bag containing the mixture was sealed and allowed to stand in a constant temperature bath at 60° C. for one day, a sensory evaluation of the unpleasant odor generated was performed as follows.
[sensory evaluation]
The unpleasant odor of Test Example 4-1-1 was given a score of 10 (control), and was evaluated on an 11-point scale from 0 (no unpleasant odor) to 10 (strong unpleasant odor) depending on the intensity of the unpleasant odor. The evaluation was performed by three people, and the average value is shown in Table 4-2 below.
<試験例4-2>
-顆粒の調製-
撹拌混合造粒装置(VGmm、株式会社パウレック製)にて、下記表4-3に記載した量のビタミンB1と、ビタミンB6と、ケイ酸カルシウムとを混合した後、下記表4-3に記載した量の水を滴下して顆粒状になるまで造粒し、造粒物を得た。
前記造粒物を乾燥させ(棚乾燥、60℃)、16メッシュ篩にて篩過し、各顆粒サンプルとした。
<Test Example 4-2>
-Preparation of granules-
After mixing vitamin B1, vitamin B6, and calcium silicate in the amounts listed in Table 4-3 below using a stirring mixing granulation device (VGmm, manufactured by Powrex Co., Ltd.), mix the amounts listed in Table 4-3 below. This amount of water was added dropwise and the mixture was granulated until it became granular, thereby obtaining a granulated product.
The granules were dried (shelf drying, 60° C.) and sieved through a 16 mesh sieve to obtain each granule sample.
-混合物の調製・評価-
ポリエチレン袋中で、下記表4-4に記載した量の、ビタミンB1と、ビタミンB6と、ロイシン、又は前記顆粒サンプルと、ロイシンとを混合した後、下記表4-4に記載した量の水を滴下しながら混合し、混合物を得た。
前記混合物を含むポリエチレン袋を密封し、60℃の恒温槽に1日間静置した後、発生する不快臭に対する官能評価を以下のようにして実施した。
[官能評価]
試験例4-2-1の不快臭を10点(コントロール)とし、不快臭の強さに応じて0点(不快臭がしない)~10点(不快臭が強い)の11段階で評価した。評価は6名で行い、その平均値を下記表4-4に示した。
-Preparation and evaluation of mixtures-
After mixing vitamin B1, vitamin B6, leucine, or the granule sample and leucine in the amounts listed in Table 4-4 below in a polyethylene bag, add water in the amount listed in Table 4-4 below. was added dropwise to obtain a mixture.
After the polyethylene bag containing the mixture was sealed and allowed to stand in a constant temperature bath at 60° C. for one day, a sensory evaluation of the unpleasant odor generated was performed as follows.
[sensory evaluation]
The unpleasant odor of Test Example 4-2-1 was given a score of 10 (control), and was evaluated on an 11-point scale from 0 (no unpleasant odor) to 10 (strong unpleasant odor) depending on the intensity of the unpleasant odor. The evaluation was conducted by six people, and the average value is shown in Table 4-4 below.
試験例4の結果から、無機多孔質体と、ビタミンB群の化合物と、アミノ酸との混合順序を変えた場合でも、ビタミンB群の化合物とアミノ酸とが共存する場合に生じる不快臭を抑制できることが確認された。また、無機多孔質体と、ビタミンB群の化合物とを混合した後に、アミノ酸を混合すると、不快臭の抑制効果がより優れることも確認された。 From the results of Test Example 4, even if the mixing order of the inorganic porous material, the vitamin B group compound, and the amino acid is changed, the unpleasant odor that occurs when the vitamin B group compound and the amino acid coexist can be suppressed. was confirmed. Furthermore, it was also confirmed that when an amino acid is mixed after mixing the inorganic porous material and a compound of the vitamin B group, the unpleasant odor suppressing effect is more excellent.
(試験例5)
ポリエチレン袋中で、3.0gのビタミンB1と、3.0gのビタミンB6と、2.0gの下記表5-1~5-2に記載の各種アミノ酸又はその塩と、3.0gのケイ酸カルシウム(試験例番号の末尾が2のもののみ)とを混合した後、1.0g(試験例番号の末尾が1のもの)、又は1.4g(試験例番号の末尾が2のもの)の水を添加して混合し、混合物を得た。
前記混合物を含むポリエチレン袋を密封し、60℃の恒温槽に1日間静置した後、発生する不快臭に対する官能評価を以下のようにして実施した。
[官能評価]
試験例5-1-1の不快臭を10点(コントロール)とし、不快臭の強さに応じて0点(不快臭がしない)~10点(不快臭が強い)の11段階で評価した。評価は6名で行い、その平均値を下記表5-1~5-2に示した。
(Test example 5)
In a polyethylene bag, 3.0 g of vitamin B1, 3.0 g of vitamin B6, 2.0 g of various amino acids or their salts listed in Tables 5-1 to 5-2 below, and 3.0 g of silicic acid. After mixing with calcium (only those whose test example numbers end with 2), 1.0 g (those whose test example numbers end with 1) or 1.4 g (those whose test example numbers end with 2). Water was added and mixed to obtain a mixture.
After the polyethylene bag containing the mixture was sealed and allowed to stand in a constant temperature bath at 60° C. for one day, a sensory evaluation of the unpleasant odor generated was performed as follows.
[sensory evaluation]
The unpleasant odor of Test Example 5-1-1 was given a score of 10 (control), and was evaluated on an 11-point scale from 0 (no unpleasant odor) to 10 (strong unpleasant odor) depending on the intensity of the unpleasant odor. The evaluation was conducted by six people, and the average values are shown in Tables 5-1 and 5-2 below.
試験例5の結果から、ロイシン以外のアミノ酸又はその塩と、ビタミンB群の化合物とを共存させた場合でも同様に、不快臭が生じることが確認された。また、無機多孔質体を用いることで、上記と同様に前記不快臭を抑制できることも確認された。 From the results of Test Example 5, it was confirmed that an unpleasant odor was similarly produced even when an amino acid other than leucine or a salt thereof and a compound of the vitamin B group coexisted. It was also confirmed that by using an inorganic porous material, the unpleasant odor can be suppressed in the same manner as above.
(試験例6)
ポリエチレン袋中で、下記表6に記載した量の、ビタミンB1とビタミンB6とロイシン、又はビタミンB1とビタミンB6とロイシンとケイ酸カルシウムを混合した後、下記表6に記載した量の水を滴下しながら混合し、混合物を得た。
前記混合物を含むポリエチレン袋を密封し、60℃の恒温槽に1日間静置した後、発生する不快臭に対する官能評価を以下のようにして実施した。
[官能評価]
試験例6-1の不快臭を10点(コントロール)とし、不快臭の強さに応じて0点(不快臭がしない)~10点(不快臭が強い)の11段階で評価した。評価は6名で行い、その平均値を下記表6に示した。
(Test Example 6)
In a polyethylene bag, mix vitamin B1, vitamin B6, and leucine, or vitamin B1, vitamin B6, leucine, and calcium silicate in the amounts listed in Table 6 below, then add dropwise the amount of water listed in Table 6 below. While mixing, a mixture was obtained.
After the polyethylene bag containing the mixture was sealed and allowed to stand in a constant temperature bath at 60° C. for one day, a sensory evaluation of the unpleasant odor generated was performed as follows.
[sensory evaluation]
The unpleasant odor of Test Example 6-1 was given a score of 10 (control), and was evaluated on an 11-point scale from 0 (no unpleasant odor) to 10 (strong unpleasant odor) depending on the intensity of the unpleasant odor. The evaluation was performed by six people, and the average value is shown in Table 6 below.
試験例6の結果から、無機多孔質体を用いることで、ビタミンB群の化合物と、アミノ酸又はその塩との質量比が変わった場合でも、これらの化合物が共存するときに生じる不快臭を抑制できることが確認された。 From the results of Test Example 6, by using an inorganic porous material, even if the mass ratio of vitamin B group compounds and amino acids or their salts changes, the unpleasant odor that occurs when these compounds coexist can be suppressed. It was confirmed that it can be done.
(試験例7)
-顆粒の調製-
撹拌混合造粒装置(VGmm、株式会社パウレック製)にて、下記表7-1に記載した量の各成分を混合した後、水を適量滴下して顆粒状になるまで造粒し、造粒物を得た。
前記造粒物を乾燥させ(棚乾燥、60℃)、16メッシュ篩にて篩過し、各顆粒とした。
(Test Example 7)
-Preparation of granules-
After mixing each component in the amounts listed in Table 7-1 below using a stirring mixing granulator (VGmm, manufactured by Powrex Co., Ltd.), add an appropriate amount of water and granulate until it becomes granular. I got something.
The granules were dried (shelf drying, 60° C.) and sieved through a 16 mesh sieve to obtain each granule.
-打錠末の調製-
下記表7-2に記載した成分のうち、ステアリン酸カルシウム以外の各成分を下記表7-2に記載した量で混合し、混合末を得た。前記混合末を造粒し顆粒とした後、下記表7-2に記載した量のステアリン酸カルシウムを添加、混合し、各打錠末とした。
なお、使用した各成分の詳細は、以下の通りである。
・ ニコチン酸アミド(ニコチン酸アミドNT、Vertellus Stecialtes Inc製)
・ パントテン酸カルシウム(パントテン酸カルシウム、DSMニュートリションジャパン株式会社製)
・ ロイシン(L-ロイシン、味の素ヘルシーサプライ株式会社製)
・ イノシトール(イノシトール、築野ライスファインケミカルズ株式会社製)
・ ビタミンB12(VB12・1000倍散、オルガノフードテック株式会社製)
・ 葉酸(葉酸、DSMニュートリションジャパン株式会社製)
・ ビオチン(食添用ビオチン1%、DSMニュートリションジャパン株式会社製)
・ 結晶セルロース(セオラス UF-F711、旭化成株式会社製)
・ ステアリン酸カルシウム(ステアリン酸カルシウム、堺化学工業株式会社製)
-Preparation of tablet powder-
Among the components listed in Table 7-2 below, each component other than calcium stearate was mixed in the amounts listed in Table 7-2 below to obtain a mixed powder. After the mixed powder was granulated into granules, calcium stearate in the amount shown in Table 7-2 below was added and mixed to form each tablet powder.
The details of each component used are as follows.
・Nicotinamide (Nicotinamide NT, manufactured by Vertellus Stecialtes Inc.)
・ Calcium pantothenate (calcium pantothenate, manufactured by DSM Nutrition Japan Co., Ltd.)
・Leucine (L-leucine, manufactured by Ajinomoto Healthy Supply Co., Ltd.)
・Inositol (Inositol, manufactured by Tsukino Rice Fine Chemicals Co., Ltd.)
・ Vitamin B12 (VB12 1000 times powder, manufactured by Organo Food Tech Co., Ltd.)
・Folic acid (folic acid, manufactured by DSM Nutrition Japan Co., Ltd.)
・Biotin (biotin for food additive use 1%, manufactured by DSM Nutrition Japan Co., Ltd.)
・Crystalline cellulose (CEOLUS UF-F711, manufactured by Asahi Kasei Corporation)
・ Calcium stearate (calcium stearate, manufactured by Sakai Chemical Industry Co., Ltd.)
-打錠・評価-
ロータリー式打錠機(VEL5、株式会社菊水製作所製)を用い、前記表7-2に記載の組成の打錠末を10kN、15kN、又は20kNの圧力で充填加圧して打錠加工し、直径10mm、曲率半径(R)8.5mm、440mg/錠の錠剤を得た。
前記錠剤の硬度を、全自動錠剤測定Multicheck5.1(ERWEKA社製)を用いて測定した。結果を下記表7-3に示した。
また、前記錠剤をアルミパウチに入れ、30℃、相対湿度80%の恒温恒湿層に開放状態で3時間静置した後、発生する不快臭に対する官能評価を以下のようにして実施した。
[官能評価]
試験例7-1の不快臭を10点(コントロール)とし、不快臭の強さに応じて0点(不快臭がしない)~10点(不快臭が強い)の11段階で評価した。評価は6名で行い、その平均値を下記表7-3に示した。
-Tablet compression/evaluation-
Using a rotary tabletting machine (VEL5, manufactured by Kikusui Seisakusho Co., Ltd.), the tablet powder having the composition shown in Table 7-2 was filled and pressurized at a pressure of 10 kN, 15 kN, or 20 kN to form a tablet. Tablets with a diameter of 10 mm, a radius of curvature (R) of 8.5 mm, and a weight of 440 mg/tablet were obtained.
The hardness of the tablet was measured using a fully automatic tablet measuring device Multicheck 5.1 (manufactured by ERWEKA). The results are shown in Table 7-3 below.
Further, the tablets were placed in an aluminum pouch and left open in a constant temperature and humidity layer at 30° C. and 80% relative humidity for 3 hours, and then a sensory evaluation of the unpleasant odor generated was performed as follows.
[sensory evaluation]
The unpleasant odor of Test Example 7-1 was given a score of 10 (control), and was evaluated on an 11-point scale from 0 (no unpleasant odor) to 10 (strong unpleasant odor) depending on the intensity of the unpleasant odor. The evaluation was conducted by 6 people, and the average value is shown in Table 7-3 below.
試験例7の結果から、錠剤の場合でも、ビタミンB群の化合物と、アミノ酸又はその塩とが共存する場合に不快臭が生じることが確認された。また、無機多孔質体を用いることで、錠剤の場合でも前記不快臭を抑制できることも確認された。
また、無機多孔質体を用いた錠剤では、錠剤硬度が上昇していることも確認された。
From the results of Test Example 7, it was confirmed that even in the case of tablets, an unpleasant odor occurs when a vitamin B group compound and an amino acid or a salt thereof coexist. It was also confirmed that by using an inorganic porous material, the unpleasant odor can be suppressed even in the case of tablets.
It was also confirmed that the tablets using the inorganic porous material had increased tablet hardness.
Claims (10)
(B)アミノ酸又はその塩と、
(C)ケイ酸カルシウムとを含有し、
前記(A)ビタミンB群から選択される少なくとも1種の化合物が、ビタミンB1及びビタミンB6を含み、
前記(B)アミノ酸又はその塩におけるアミノ酸が、ロイシン、バリン、イソロイシン、フェニルアラニン、セリン、ヒスチジン、グリシン、アルギニン、グルタミン酸、アラニン、システイン、チロシン、グルタミン、及びシトルリンからなる群から選択される少なくとも1種であり、
前記(A)成分の含有量が、栄養補助組成物100質量部に対して、1質量部以上であり、
前記(B)成分の含有量が、栄養補助組成物100質量部に対して、1質量部~60質量部であり、
前記(C)成分の含有量が、栄養補助組成物100質量部に対して、3質量部~50質量部であり、
前記(A)成分のビタミンB1及びビタミンB6の合計量と、前記(B)アミノ酸又はその塩との質量比[{(ビタミンB1)+(ビタミンB6)}/(アミノ酸又はその塩)]が、1以上であることを特徴とする栄養補助組成物。 (A) at least one compound selected from the vitamin B group;
(B) an amino acid or a salt thereof;
(C) containing calcium silicate;
(A) at least one compound selected from the vitamin B group includes vitamin B1 and vitamin B6;
The amino acid in the amino acid (B) or its salt is at least one selected from the group consisting of leucine, valine, isoleucine, phenylalanine, serine, histidine, glycine, arginine, glutamic acid, alanine, cysteine, tyrosine, glutamine, and citrulline. and
The content of the component (A) is 1 part by mass or more with respect to 100 parts by mass of the nutritional supplement composition,
The content of the component (B) is 1 part by mass to 60 parts by mass with respect to 100 parts by mass of the nutritional supplement composition,
The content of the component (C) is 3 parts by mass to 50 parts by mass with respect to 100 parts by mass of the nutritional supplement composition,
The mass ratio of the total amount of vitamin B1 and vitamin B6 of the component (A) to the amino acid or salt thereof (B) [{(vitamin B1) + (vitamin B6)}/(amino acid or salt thereof)] is 1 or more .
前記(A)ビタミンB群から選択される少なくとも1種の化合物が、ビタミンB1及びビタミンB6を含み、(A) at least one compound selected from the vitamin B group includes vitamin B1 and vitamin B6;
前記(B)アミノ酸又はその塩におけるアミノ酸が、ロイシン、バリン、イソロイシン、フェニルアラニン、セリン、ヒスチジン、グリシン、アルギニン、グルタミン酸、アラニン、システイン、チロシン、グルタミン、及びシトルリンからなる群から選択される少なくとも1種であり、The amino acid in the amino acid (B) or its salt is at least one selected from the group consisting of leucine, valine, isoleucine, phenylalanine, serine, histidine, glycine, arginine, glutamic acid, alanine, cysteine, tyrosine, glutamine, and citrulline. and
前記(A)成分の含有量が、栄養補助組成物100質量部に対して、1質量部以上であり、The content of the component (A) is 1 part by mass or more with respect to 100 parts by mass of the nutritional supplement composition,
前記(B)成分の含有量が、栄養補助組成物100質量部に対して、1質量部~60質量部であり、The content of the component (B) is 1 part by mass to 60 parts by mass with respect to 100 parts by mass of the nutritional supplement composition,
前記(C)成分の含有量が、栄養補助組成物100質量部に対して、3質量部~50質量部であり、The content of the component (C) is 3 parts by mass to 50 parts by mass with respect to 100 parts by mass of the nutritional supplement composition,
前記(A)成分のビタミンB1及びビタミンB6の合計量と、前記(B)アミノ酸又はその塩との質量比[{(ビタミンB1)+(ビタミンB6)}/(アミノ酸又はその塩)]が、1以上であることを特徴とする栄養補助組成物の製造方法。The mass ratio of the total amount of vitamin B1 and vitamin B6 of the component (A) to the amino acid or salt thereof (B) [{(vitamin B1) + (vitamin B6)}/(amino acid or salt thereof)] is 1 or more.
前記第1の混合処理で得られた混合物と、前記(B)アミノ酸又はその塩とを混合する第2の混合処理とを含む請求項3に記載の栄養補助組成物の製造方法。The method for producing a nutritional supplement composition according to claim 3, comprising a second mixing process of mixing the mixture obtained in the first mixing process and the amino acid (B) or a salt thereof.
前記(A)ビタミンB群から選択される少なくとも1種の化合物と、前記(B)アミノ酸又はその塩と、(C)ケイ酸カルシウムとを混合する混合工程を含み、A mixing step of mixing the (A) at least one compound selected from the vitamin B group, the (B) amino acid or its salt, and (C) calcium silicate;
前記(B)アミノ酸又はその塩におけるアミノ酸が、ロイシン、バリン、イソロイシン、フェニルアラニン、セリン、ヒスチジン、グリシン、アルギニン、グルタミン酸、アラニン、システイン、チロシン、グルタミン、及びシトルリンからなる群から選択される少なくとも1種であり、The amino acid in the amino acid (B) or its salt is at least one selected from the group consisting of leucine, valine, isoleucine, phenylalanine, serine, histidine, glycine, arginine, glutamic acid, alanine, cysteine, tyrosine, glutamine, and citrulline. and
前記(A)成分の含有量が、栄養補助組成物100質量部に対して、1質量部以上であり、The content of the component (A) is 1 part by mass or more with respect to 100 parts by mass of the nutritional supplement composition,
前記(B)成分の含有量が、栄養補助組成物100質量部に対して、0.1質量部~70質量部であり、The content of the component (B) is 0.1 parts by mass to 70 parts by mass with respect to 100 parts by mass of the nutritional supplement composition,
前記(C)成分の含有量が、栄養補助組成物100質量部に対して、3質量部~50質量部であることを特徴とする不快臭の抑制方法。A method for suppressing an unpleasant odor, characterized in that the content of the component (C) is 3 parts by mass to 50 parts by mass based on 100 parts by mass of the nutritional supplement composition.
前記第1の混合処理で得られた混合物と、前記(B)アミノ酸又はその塩とを混合する第2の混合処理とを含む請求項5に記載の不快臭の抑制方法。The method for suppressing an unpleasant odor according to claim 5, comprising a second mixing process of mixing the mixture obtained in the first mixing process and the amino acid (B) or a salt thereof.
ケイ酸カルシウムを含有する不快臭抑制用組成物であって、An unpleasant odor suppressing composition containing calcium silicate,
前記栄養補助組成物における前記(A)成分の含有量が、栄養補助組成物100質量部に対して、1質量部以上であり、The content of the component (A) in the nutritional supplement composition is 1 part by mass or more with respect to 100 parts by mass of the nutritional supplement composition,
前記栄養補助組成物における前記(B)成分の含有量が、栄養補助組成物100質量部に対して、0.1質量部~70質量部であることを特徴とする不快臭抑制用組成物。A composition for suppressing unpleasant odor, wherein the content of the component (B) in the nutritional supplement composition is 0.1 parts by mass to 70 parts by mass based on 100 parts by mass of the nutritional supplement composition.
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