JP7433743B2 - Emulsified composition with pearl-like luster - Google Patents

Description

The present invention relates to an emulsified composition that has a pearl-like luster and has good feel when applied to the skin (spreading feeling, skin-friendly feeling, penetration feeling) and excellent skin barrier properties.

BACKGROUND OF THE INVENTION There has been a desire for creams that spread well when applied to the skin, have good skin absorption, and have good permeability. On the other hand, some emulsified compositions having pearl-like luster spread well when applied to the skin, and have good skin familiarity and permeability (see Patent Documents 1 to 3, etc.). However, it is not known that emulsified compositions having pearl-like luster have a barrier function.

On the other hand, emulsified compositions having an α-gel structure and a lamellar structure are known to have high skin barrier properties, but do not necessarily provide a good feeling when applied to the skin.

Special Publication No. 60-26764 Japanese Patent Application Publication No. 11-49639 Japanese Patent Application Publication No. 11-180822

The present invention provides an emulsified composition, especially an emulsified composition for external use, which has a good feel when applied to the skin (feeling of spreading, feeling of adhesion to the skin, and feeling of penetration), has excellent skin barrier properties, and has a pearl-like luster appearance. The purpose is to provide.

Embodiments of the invention are as follows.

(I-1) An emulsified composition having a lamellar liquid crystal structure and an α-gel structure, and having a pearl-like lustrous appearance.
(I-2) The product described in (I-1) containing 5 to 25% by mass of higher fatty acids, 2 to 10% by mass of higher fatty acid salts, and 0.5 to 8% by mass of higher alcohols. emulsifying composition.
(I-3) The higher fatty acid of the higher fatty acid and the higher fatty acid salt are the same or different and are saturated or unsaturated fatty acids having 14 to 18 carbon atoms, according to (I-1) or (I-2). emulsifying composition.
(I-4) The emulsion composition according to any one of (I-1) to (I-3), wherein the higher alcohol is a saturated or unsaturated monohydric alcohol having 14 to 18 carbon atoms.

(I-5) The emulsified composition according to any one of (I-1) to (I-4), which has a saponification rate of 20 to 40%, preferably about 30%.
(I-6) The emulsified composition according to any one of (I-1) to (I-5), further containing a liquid saturated glycol.
(I-7) The emulsion composition according to (I-6), wherein the content of liquid saturated glycol is 0.5 to 60% by mass.
(I-8) The liquid saturated glycol is at least one selected from the group consisting of propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol, (I-6) or (I-7) The emulsified composition described in any one of.
(I-9) The emulsion composition according to any one of (I-1) to (I-8), which is an O/W type emulsion composition.
(I-10) The emulsified composition according to any one of (I-1) to (I-9), which is an external preparation for skin.

The emulsified composition of the present invention has an α-gel structure and a lamellar structure, and has a pearl-like luster appearance, and has a feeling of use when applied to the skin (feeling of spreading, feeling of adhesion to the skin, feeling of penetration). It has good skin barrier properties. Therefore, by applying the emulsified composition of the present invention to the skin, one can experience the above-mentioned good feeling of use. Furthermore, since it has good skin barrier properties, it has good water retention (moisturizing) properties, and is also expected to have the effect of protecting the skin from external irritants.

(a) Shows the results of measuring the small angle region (2θ=0 to 10 degrees) using an X-ray diffraction device for the emulsion composition of Example 1. (b) Shows the results of measuring the small angle region (2θ=0 to 10 degrees) using an X-ray diffraction device for the emulsion composition of Comparative Example 2. (a) Shows the results of measuring the emulsion composition of Example 1 in a wide-angle region (2θ=3 to 30 degrees) using an X-ray diffraction device. (b) Shows the results of measuring the emulsion composition of Comparative Example 2 in a wide-angle region (2θ=3 to 30 degrees) using an X-ray diffraction device.

(I) Emulsified composition
(1) Structure The emulsion composition of the present invention is characterized by having a lamellar liquid crystal structure and an α-gel structure under conditions of room temperature (25±5° C.) and atmospheric pressure.

In addition, it can be confirmed by X-ray structural analysis using an X-ray diffraction device that the emulsified composition has a lamellar liquid crystal structure. Specifically, when it has a lamellar liquid crystal structure, X-ray structural analysis reveals the appearance of regular peaks in the small angle region (2θ=0 to 10 degrees). More specifically, when the peak ratio of each peak of d1:d2:d3:d4... is observed to have a regularity of 1:1/2:1/3:1/4..., a lamellar liquid crystal structure is obtained. The existence of is confirmed. The emulsified composition of the present invention has lattice constants of 49.0 Å (Bragg angle 1.80°), 24.4 Å (Bragg angle 3.62°), and 16.2 Å, as shown in FIG. 1(a), for example, by X-ray structural analysis. (Bragg angle 5.46°), 12.1 Å (Bragg angle 7.30°), 9.7 Å (Bragg angle 9.14°), regularity of peak ratio 1:1/2:1/3:1/4:1/5 Includes emulsified compositions in which a certain peak is observed.

The emulsified composition of the present invention develops a pearl-like luster color as described below due to the light interference effect derived from the lamellar liquid crystal structure, and has a very beautiful appearance. Therefore, it is useful as an emulsion composition in the field of cosmetics in pursuit of beauty.

Furthermore, the fact that the emulsified composition has an α-gel structure can be confirmed by X-ray structure analysis using an X-ray diffraction apparatus in the same manner as described above. Specifically, when it has an α-gel structure, X-ray structural analysis reveals a single sharp diffraction peak around a Bragg angle of 21 to 23°. The emulsifying composition of the present invention includes, for example, an emulsifying composition in which a sharp peak is observed at a Bragg angle of 21.4° (lattice constant 4.14 Å) as shown in FIG. 2(a).

The emulsifying composition of the present invention has amphiphilic liquid crystal lamellar structure, with bound water (water bound to constituent molecules) between the lamellar layers and free water (held between the lamellar structure constituents). It has a layered α-gel structure that retains water (unbound by water). Therefore, it has excellent moisturizing properties, and when used, has good spreadability, good skin compatibility, good permeability, and excellent feel when used. In addition, the lamellar liquid crystal structure has a barrier function (skin barrier function) similar to that of intercellular lipids in the skin, and by suppressing the evaporation of water from the skin, it also has excellent water retention (moisturizing ability). It can also protect the skin from external irritants (harmful substances). Therefore, the emulsified composition of the present invention having a lamellar liquid crystal structure can be particularly suitably used as a skin care cosmetic.

(2) Appearance The emulsified composition of the present invention is characterized by having a pearl-like lustrous appearance at least at room temperature (25±5°C). Preferably, it has the above-mentioned appearance under storage conditions of about -20 to 35°C. Pearl-like luster is also called pearlescent luster, and both are used interchangeably. The pearl-like luster is an effect obtained when the emulsified composition is subjected to light interference due to its lamellar liquid crystal structure. Since the emulsion composition of the present invention has a beautiful appearance as described above, it can be suitably used as an external composition in the field of cosmetics.

(3) Composition The composition of the emulsified composition of the present invention is not particularly limited as long as it has the above structure and appearance, but preferably contains a higher fatty acid, a higher fatty acid salt, and a higher alcohol.

(A) Higher fatty acid In the present invention, the higher fatty acid is preferably a saturated or unsaturated fatty acid having 14 to 18 carbon atoms, although it is not limited thereto. Such fatty acids include myristic acid (14:0), pentadecyl acid (15:0), palmitic acid (16:0), palmitoleic acid (16:1), margaric acid (17:0), and stearic acid (18:0). 0), oleic acid (18:1), vaccenic acid (18:1), linoleic acid (18:2), linolenic acid (18:3), and eleostearic acid (18:3). . Note that the number in parentheses after the above chemical name indicates the number of carbon atoms in the fatty acid, and the latter indicates the number of double bonds. From the viewpoint of good usability, saturated fatty acids having 16 to 18 carbon atoms are more preferred, and palmitic acid, stearic acid, and margaric acid are particularly preferred.

Although the content of these higher fatty acids in the emulsified composition of the present invention is not limited, it is usually about 5 to 25% by mass. Preferably it is 7 to 20% by weight, more preferably 7 to 11% by weight.

(B) Higher fatty acid salts Higher fatty acid salts are produced by the reaction of alkali with higher fatty acids used as raw materials in the manufacturing process, but are not limited to those that are separately added and blended. It may exist, and its origin is not particularly limited.

Although the higher fatty acid constituting the higher fatty acid salt is not limited, it is preferably a saturated or unsaturated fatty acid having 14 to 18 carbon atoms. Such fatty acids include myristic acid (14:0), pentadecyl acid (15:0), palmitic acid (16:0), palmitoleic acid (16:1), and margaric acid (17:0), as well as the above-mentioned higher fatty acids. ), stearic acid (18:0), oleic acid (18:1), vaccenic acid (18:1), linoleic acid (18:2), linolenic acid (18:3), and eleostearic acid (18: 3). From the viewpoint of good usability, saturated fatty acids having 16 to 18 carbon atoms are more preferred, and palmitic acid, stearic acid, and margaric acid are particularly preferred.

Examples of higher fatty acid salts include alkali metal salts (sodium fatty acids, potassium fatty acids, etc.), alkaline earth metal salts (such as magnesium fatty acids, calcium fatty acids, barium fatty acids, etc.), and ammonia salts (ammonium fatty acids) of the above-mentioned higher fatty acids. , the above-mentioned higher fatty acids and amines, hydroxylamines, imines, guanidines, amine oxides, alkanolamines, alkoxylated amines, and alkylamines (diethanolamine, triethanolamine, isopropanolamine, diisopropanolamine, triisopropanolamine, aminobutanol, aminoethylpropanediol, aminomethylpropanol, aminomethylpropanediol, isopropylamine, methylethanolamine, diisopropylamine, dipropylenetriamine, glucamine, N-methylglucamine, morpholine, tromethamine), cocamine Examples include reactants with organic amines such as soyamines, oleamines, stearamines, and quaterniums. Preferred are alkali metal salts or alkaline earth metal salts of fatty acids, and more preferred are fatty acid sodium salts or fatty acid potassium salts, which are alkali metal salts of fatty acids.

Although the content of these higher fatty acid salts in the emulsified composition of the present invention is not limited, it is usually about 2 to 10% by mass. Preferably it is 2 to 9% by weight, more preferably 3 to 9% by weight.

(C) Higher alcohol In the present invention, the higher alcohol is preferably a saturated or unsaturated monohydric alcohol having 14 to 18 carbon atoms, although it is not limited thereto. Examples of such higher alcohols include myristyl alcohol, pentadecyl alcohol, cetanol, settosaryl alcohol, palmitoleyl alcohol, 1-heptadecanol, stearyl alcohol, isostearyl alcohol, elaidyl alcohol, oleyl alcohol, linoleyl alcohol, and ricinoleyl alcohol. Mention may be made of fatty alcohols such as alcohols or synthetic alcohols. From the viewpoint of good usability, saturated monohydric alcohols having 16 to 18 carbon atoms are preferred, and cetanol, cetosaryl alcohol, palmitrail alcohol, 1-heptadecanol, stearyl alcohol, and isostearyl alcohol are particularly preferred. , oleyl alcohol.

The content of these higher alcohols in the emulsified composition of the present invention is not limited, but is usually about 0.5 to 8% by mass. Preferably it is 1 to 8% by weight, more preferably 1 to 3% by weight.

(D) Liquid saturated glycol The emulsified composition of the present invention may contain a liquid saturated glycol. The liquid saturated glycol acts as a humectant or emollient to the skin. Examples of such liquid saturated glycols include, but are not limited to, at least one selected from the group consisting of propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol. Preferred are propylene glycol, dipropylene glycol and polyethylene glycol, more preferred are propylene glycol and polyethylene glycol. The content of liquid saturated glycol in the present invention is not limited, but may be in the range of 0.5 to 60% by mass. Preferably it is 1 to 60% by weight, more preferably 5 to 60% by weight.

(E) Other components The emulsified composition of the present invention may be used in addition to the above-mentioned (A) to (C) components or the above-mentioned (A) to (D) components, as long as the structure and appearance of the present invention are not impaired. Other ingredients may also be included. Examples of such components include humectants, thickeners, surfactants, oily components, antioxidants, preservatives and disinfectants, powder components, fragrances, pigments, and water.

Moisturizing agents include, but are not limited to, glycerin; sugars such as sorbitol, xylitol, and trehalose; sodium pyrrolidone carboxylate, lactic acid bacteria-fermented rice, hyaluronic acid and its derivatives (for example, hyaluronic acid with a molecular weight of several thousand to several million, or its derivatives); salts, acetylated hyaluronic acid, propylene glycol hyaluronate, hydroxypropyltrimonium hyaluronate, etc.), mucopolysaccharides (e.g. chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, hydrolysis Silk protein, lactic acid, urea, higher fatty acid octyldodecyl, phytosterol, soybean phospholipid, cholesteryl isostearate, seaweed extract, seafood-derived collagen and its derivatives, various amino acids and their derivatives (such as trimethylglycine), loofah extract , Byakkyu extract, fermented soybean milk, natto extract, rice-derived extract, and fermented products thereof.

Examples of thickeners include, but are not limited to, components derived from brown algae, green algae, or red algae such as alginic acid, agar, carrageenan, and fucoidan; polysaccharides such as sand chestnut extract, pectin, locust bean gum, and aloe polysaccharide; xanthan gum and tragacanth gum. , Gums such as guar gum; Cellulose derivatives such as carboxymethylcellulose and hydroxyethylcellulose; Synthetic polymers such as polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, and acrylic acid/methacrylic acid copolymer; Polyglutamic acid and its derivatives; Glucosyl trehalose and sugar compounds mainly composed of hydrolyzed hydrogenated starch.

Examples of surfactants include, but are not limited to, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, and hardened polyoxyethylene. Nonionic surfactants such as castor oil and polyoxyethylene sorbitol fatty acid esters; fatty acid salts, alkyl sulfates, alkylbenzene sulfonates, polyoxyethylene alkyl ether sulfates, polyoxyethylene fatty amine sulfates, polyoxyethylene alkylphenyl Anionic surfactants such as ether sulfates, polyoxyethylene alkyl ether phosphates, α-sulfonated fatty acid alkyl ester salts, polyoxyethylene alkyl phenyl ether phosphates; quaternary ammonium salts, primary to tertiary fats Cation interfaces such as group amine salts, trialkylbenzylammonium salts, alkylpyridinium salts, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salts, N,N-dialkylmorphonium salts, polyethylene polyamine fatty acid amide salts, etc. Activator: N,N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N,N,N-trialkyl-N-alkyleneammoniocarboxybetaine, N-acylamidoprol-N',N' Examples include amphoteric surfactants such as -dimethyl-N'-β-hydroxypropylammoniosulfobetaine. In addition, as emulsifiers or emulsification aids, stevia derivatives such as enzyme-treated stevia, lecithin and its derivatives, lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented grains (wheat, beans, millet, etc.), birch extract, etc. are blended. You can also.

Examples of oily components include, but are not limited to, hydrocarbons such as liquid paraffin, petrolatum, paraffin wax, and squalane.

Antioxidants include, but are not limited to, butylated hydroxyanisole, butylated hydroxytoluene, propyl gallate, vitamin E and its derivatives, vitamin C (ascorbic acid) and its derivatives, ubidecaquinone (ubiquinone), rutin, rutin glucoside, white Examples include poppy extract, rice extract, purple beetroot extract, birch extract, hamamelis extract, oolong tea extract, black bean hydrolyzed extract, peony extract, sandbarium extract, and japonica extract.

Preservatives and disinfectants include, but are not limited to, urea, paraoxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, phenoxyethanol, dichlorophen, hexachlorophene, and hydrochloric acid. Examples include chlorhexidine, benzalkonium chloride, salicylic acid, ethanol, undecylenic acid, phenols, jamal (imidazodeinyl urea), bark dry distillate, propolis extract, methylisothiazolinone, and the like.

Powder components include, but are not limited to, sericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, 6- or 12-nylon. powder, polyethylene powder, silk powder, cellulose powder, grain powder (rice, wheat, corn, millet, etc.), and legume powder (soybean, adzuki bean, etc.).

Furthermore, if necessary, other physiologically active ingredients (fibroblast activators, whitening agents, skin aging prevention/improving skin roughness, etc.) may be blended within a range that does not impede the effects of the present invention.

Examples of fibroblast activators include, but are not limited to, bilberry leaf extract, polyamines, aloe extract, cuckoo extract, chlorella extract, placenta extract, sugar maple sap, royal jelly, yeast extract, mucopolysaccharide body fluid, astragalus extract, soybean extract, Examples include whey.

Examples of whitening agents include, but are not limited to, t-cycloamino acid derivatives, kojic acid and its derivatives, vitamin C (ascorbic acid) and its derivatives, hydroquinone or its derivatives, ellagic acid and its derivatives, nicotinic acid and its derivatives, resorcinol. Derivatives, tranexamic acid and its derivatives, 4-methoxysalicylic acid potassium salt, magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), 4-HPB (rhododenol, 4-(4-hydroxyphenyl)- 4-butanol)), hydroxybenzoic acid and its derivatives, vitamin E and its derivatives, α-hydroxy acid, AMP (adenosine monophosphate, adenosine monophosphate), placenta extract, sagebrush extract, saxifrage extract, rice bran Extracts or hydrolysates thereof, white mustard extracts or hydrolysates thereof, fermented white mustards, peony extracts or hydrolysates thereof, lactic acid bacteria-fermented rice, lactic acid bacteria-fermented germinated rice, lactic acid bacteria-fermented grains (wheat, beans) , cereals), purple beetles extract, lotus seed extract or its hydrolyzate, lotus seed ferment, party ginseng extract, adlay hydrolyzate, coix seed ferment, royal jelly ferment, sake lees ferment, Pandanus amaryllifolia Examples include Pandanus amaryllifolius Roxb. extract, Arcangelicia flava Merrilli extract, and chamomile extract.

The ingredients for preventing skin aging and improving rough skin include, but are not limited to, for example, coral grass extract, rice leaf extract or its hydrolyzate, eggplant (water eggplant, long eggplant, Kamo eggplant, rice eggplant, etc.) extract, or Hydrolysates thereof, extracts of seaweed such as Katamen Kirincho, extracts of marine flowering plants such as eelgrass, jellyfish water, rice extracts or hydrolysates thereof, fermented rice extracts, germinated rice extracts or hydrolysates thereof , fermented germinated rice, black bean extract or its hydrolyzate, animal or fish-derived collagen and its derivatives, elastin and its derivatives, intercellular lipids such as ceramide, glycyrrhizic acid and its derivatives (dipotassium salt etc.), t- Cycloamino acid derivatives, vitamin A and its derivatives, t-cycloamino acid derivatives, vitamin A and its derivatives, vitamin E and its derivatives (d,l-α-sodium tocopheryl phosphate, etc.), allantoin, α-hydroxy acids, diisopropyl Amine dichloroacetate, γ-amino-β-hydroxybutyric acid, coenzyme Q-10, α-lipoic acid, ergothioneine, allantoin, diisopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, gentian extract, licorice extract, carrot Extract, Aloe extract, Honeycomb extract, Ulva extract, Zizyphus joazeiro extract, Beech extract, Kidachi aloe extract, Stone wax extract, Ginkgo biloba extract, Horsetail extract, Safflower extract, Panax ginseng extract , Sambucus extract, Astragalus extract, Astragalus extract, Mango extract, Cherimoya extract, Mangosteen extract, Tabebuia impetiginosa extract, Yeast extract, Eggshell membrane extract protein, Deoxyribonucleic acid potassium salt, Lotus Examples include seed fermentation liquid and pollen extract.

As will be described later, the emulsified composition of the present invention is produced using higher fatty acids and alkalis as raw materials, and as a result contains a portion of the higher fatty acids in a saponified state. The saponification rate of the emulsified composition of the present invention is not limited, but can be in the range of 20 to 40%. It is preferably 20 to 35%, more preferably 25 to 35%, particularly preferably about 30%.

The emulsion composition of the present invention can be prepared by blending and mixing the above components (A) to (C), and if necessary, component (D) and/or component (E) to obtain a desired shape (solid, semi-solid). It can be prepared in various forms (gel-like, cream-like, ointment-like, etc.) and liquids [emulsion-like, lotion-like, etc.]. Preferably, it is an emulsion, particularly an O/W type emulsion, and more preferably it can be prepared as a cream-like external composition. The external composition may be included in any of the categories of pharmaceuticals, quasi-drugs, and cosmetics. Preferred are quasi-drugs for external use and cosmetics, more preferably cosmetics.

Examples of the form of external medicines or quasi-drugs include, but are not limited to, creams, ointments, plasters, poultices, lotions, emulsions, liquids, aerosols, and the like. Creams and emulsions are preferred. Although the form of cosmetics is not limited, examples of skin care cosmetics include lotion, serum, pack, massage cream, milky lotion, moisture cream, vanishing cream, cleansing cream, lip balm, and the like. Preferred are massage cream, emulsion, moisture cream, vanishing cream, and cleansing cream.

(II) Method for producing emulsified composition The emulsified composition of the present invention containing at least the above-mentioned components (A) to (C) is prepared by mixing at least higher fatty acids, alkalis, and higher alcohols as raw materials. It can be prepared through a step and a step of standing still.

The types of higher fatty acids and higher alcohols used here are as described in (I) above, and the above descriptions can be cited.

As for the amount of higher fatty acids used in the production, the proportion of higher fatty acids contained in the emulsified composition after preparation is usually about 5 to 25% by mass, preferably 7 to 20% by mass, more preferably 7 to 11% by mass, and the saponification rate in that case is 20 to 40%, preferably 20 to 35%, more preferably 25 to 35%, and there are no particular restrictions as far as it is concerned. It's not something you can do. When the total amount of raw materials for production is 100% by mass, the proportion of higher fatty acids used is usually 8 to 30% by mass. It is preferably 10 to 30% by weight, more preferably 10 to 15% by weight.

Although the amount of higher alcohol used in production is not limited, it is usually about 0.5 to 8% by mass as described in (I) when the total amount of production raw materials is 100% by mass. I can do it. Preferably it is 1 to 8% by weight, more preferably 1 to 3% by weight.

The alkali used in the production is a substance that exhibits a pH of 7 or more when made into an aqueous solution, and is a substance that reacts with the higher fatty acid to produce the higher fatty acid salt described above as a saponified product.

The alkali includes both inorganic alkali and organic alkali. Inorganic alkalis include, for example, alkali metal or alkaline earth metal hydroxide salts (e.g., sodium hydroxide, potassium hydroxide, magnesium hydroxide, calcium hydroxide, etc.), alkali metal carbonates or bicarbonates ( For example, sodium carbonate, sodium bicarbonate, potassium carbonate, potassium bicarbonate), alkali metal phosphates (e.g., sodium phosphate, potassium phosphate), inorganic salts of ammonia (e.g., ammonium hydroxide, ammonium phosphate, carbonate). or ammonium bicarbonate). Examples of organic alkalis include amines, hydroxylamines, imines, guanidines, amine oxides, alkanolamines, alkoxylated amines, and alkylamines (diethanolamine, triethanolamine, isopropanolamine, diisopropanolamine). , triisopropanolamine, aminobutanol, aminoethylpropanediol, aminomethylpropanol, aminomethylpropanediol, isopropylamine, methylethanolamine, diisopropylamine, dipropylenetriamine, glucamine, N-methylglucamine, morpholine, tromethamine), Examples include cocamines, soyamines, oleamines, stearamines, and quaterniums. Preferably it is an inorganic alkali. More preferred are alkali metal or alkaline earth metal hydroxide salts, alkali metal carbonates, bicarbonates, or phosphates, and alkali metal hydroxide salts are particularly preferred.

Although the amount of alkali used in production is not limited, it is usually about 0.5 to 5% by mass when the total amount of production raw materials is 100% by mass. It is preferably 0.5 to 2% by weight, more preferably 0.6 to 2% by weight.

Further, the ratio of the alkali to 100 parts by mass of the higher fatty acid used as the production raw material is not limited, but the saponification rate is 20 to 40%, preferably 20 to 35%, and more preferably 25 to 35%. Specific examples include, for example, 0.5 to 5 parts by weight, preferably 0.5 to 2 parts by weight, and more preferably 0.6 to 2 parts by weight, although there is no limitation. be able to.

Furthermore, when the emulsified composition of the present invention contains liquid saturated glycol and/or other optional components as other components, the emulsified composition of the present invention contains liquid saturated glycol and/or other optional components in addition to the above components. Manufactured by blending. The types of liquid saturated glycols are as described above, and the amount thereof is usually about 0.5 to 60% by mass when the total amount of raw materials for production is 100% by mass. It is preferably 1 to 60% by weight, more preferably 5 to 60% by weight.

The manufacturing method of the present invention basically includes the step of blending and mixing the above components as raw materials, as described above. Mixing depends on the shape of the emulsified composition to be produced (solid, liquid, semi-solid), formulation shape (cream, ointment, plaster, poultice, lotion, milky lotion, liquid, aerosol), route of administration (internal use, external use), and Depending on the intended use (drugs, quasi-drugs, and cosmetics), it can be carried out according to the established method. A preferred embodiment of the emulsion composition of the present invention is an emulsion composition, more preferably a cream, especially an O/W type cream. It can be prepared through an emulsification process by mixing according to the method for producing W-type cream.

The mixing process (emulsification process) can be carried out according to a standard method, such as heating the raw materials to a predetermined temperature and then stirring and emulsifying them under predetermined conditions using a mixer such as a homogenizer, homomixer, or stirrer. . More specifically, a mixture of a higher fatty acid and a higher alcohol, which has been heated and dissolved in advance, and an alkali, which has been similarly heated and dissolved in a solvent, are mixed, for example, using the above-mentioned mixer. A method of stirring and mixing can be mentioned, and in this way a desired emulsion can be prepared. Although not limited, such a mixing step is preferably performed in a heated state. Although the temperature is not particularly limited, it is preferably 60 to 90°C, preferably 70 to 90°C, and more preferably 75 to 85°C. The emulsion thus obtained is then cooled (preferably to about 30 to 35° C. or lower), thereby making it possible to prepare an emulsified composition with stable emulsification.

The emulsified composition of the present invention is subjected to a standing step after emulsification preparation. The standing step is an important step for the emulsified composition prepared above to exhibit a lamellar liquid crystal structure and an α-gel structure when measured using an X-ray diffraction device. This standing step may be carried out under any condition that allows the preparation of an emulsified composition having a liquid crystal structure and an α-gel structure, but it can usually be carried out by standing at a temperature of 5 to 40°C. Preferably, it is left to stand under a temperature condition of 10 to 30°C. Although the period of standing is not limited, it is preferably 5 to 28 days, more preferably 7 to 21 days.

(III) Beauty method The present invention improves the skin barrier function of the subject by applying the emulsified composition of the present invention described above to a subject whose skin barrier function has decreased due to aging etc. and whose moisturizing properties have decreased. This invention relates to a beauty method that improves moisturizing properties and gives a fresh and plump feeling. Note that the method targeted by the present invention is a cosmetic method and is not a therapeutic method for humans.

For example, a test subject whose skin's moisturizing properties have decreased due to aging or the like has symptoms of skin deterioration such as hard skin and a feeling of dryness.

Target subjects are preferably those who have symptoms of skin deterioration due to aging, although they are not particularly limited. Normally, both men and women over the age of 30 are likely to become such subjects. Preferably, the age is 40 years or older, more preferably 45 years or older, and even more preferably 50 years or older.

Although the emulsified composition of the present invention has a form such as a plaster, an ointment, a cream, a liniment, a lotion, a milky lotion, a liquid, or an aerosol, the emulsified composition of the present invention varies depending on its form. It can be used by applying or spraying it on the desired area of the skin. In addition, when external drugs, quasi-drugs, and cosmetics are in the form of poultices, they can be used by applying the topical drugs, quasi-drugs, and cosmetics to the skin of the subject at the desired site. Application to the skin may be performed once or multiple times a day, for example, in the morning and at night (before going to bed). In this way, it becomes possible to suppress (prevent) and improve the occurrence of skin deterioration symptoms in subjects whose skin moisturizing properties have decreased due to aging or the like.

The present invention will be described below based on experimental examples and examples. However, the experimental examples and examples are only examples of the present invention, and the present invention is not limited to these experimental examples and examples.

Experimental Example 1 Evaluation of the structure and feel of the emulsified composition (spreading, skin-compatibility, penetration feeling) and barrier function Emulsified compositions for external use on the skin (creams) having the compositions shown in Table 1 (Comparative Examples 1 to 5), and Emulsified compositions for external use on the skin (creams) (Examples 1 to 4) having the compositions shown in Table 2 were prepared, and each emulsified composition was evaluated for the presence or absence of pearl-like luster, the presence or absence of lamellar structure, and the presence or absence of α-gel structure. , the presence or absence of skin barrier function, and the feeling of use on the skin (feeling of spreading, feeling of conformity to the skin, feeling of penetration) were evaluated.

(1) Preparation of test sample (emulsified composition for external use on the skin) The emulsified compositions listed in Table 1 (Comparative Examples 1 to 5) and the emulsified compositions listed in Table 2 (Examples 1 to 4) were prepared using a vacuum emulsifier. (manufactured by Mizuho Kogyo Co., Ltd.) as follows. In addition, both the compounding amounts in Tables 1 and 2 mean mass %.

[Preparation of emulsion compositions of Examples 1 to 4 and Comparative Example 1]
1. The components of phase A listed in Tables 1 and 2, respectively, are mixed in the proportions listed and heated to 80°C.
2. Next, the components of phase B are mixed in the proportions shown in Tables 1 and 2 and heated to 80°C.
3. Next, the mixture of phase B components is gradually added to the mixture of phase A components while rotating the blades of a vacuum emulsifier at 50 rpm to emulsify.
4. Next, this was stirred while being cooled to 30°C (naturally cooling) to form an emulsified composition (cream) (test sample) having the composition shown in Table 1 (Comparative Example 1) and Table 2 (Examples 1 to 4). ).
5. Each of the prepared emulsion compositions (Comparative Example 1, Examples 1 to 4) is stored at 25° C. in the dark for 3 weeks.

[Preparation of emulsion compositions of Comparative Examples 2 to 5]
1. The components of phase A listed in Table 1 are mixed in the proportions listed in the table and heated to 80°C.
2. Next, the components of phase B are mixed in the proportions shown in Table 1 and heated to 80°C.
3. Next, the mixture of phase B components is gradually added to the mixture of phase A components while rotating the blades of a vacuum emulsifier at 10 rpm to emulsify.
4. Next, this is stirred while being cooled to 30° C. (natural cooling) to prepare an emulsified composition (cream) (test sample) having the composition shown in Table 1 (Comparative Examples 2 to 5).
5. Each of the prepared emulsion compositions (Comparative Examples 2 to 5) is left standing and stored under dark conditions at 25° C. for 3 weeks.

The preparation of the emulsified compositions of Comparative Examples 1 to 5 and Examples 1 to 4 was carried out at room temperature (25±5° C.) except for the matters mentioned above. In all of the following experiments, emulsion compositions that had been stored for 3 weeks after preparation were used.

(2) Experimental method and results (2-1) Observation of the presence or absence of pearl-like luster The emulsion compositions prepared above (Comparative Examples 1 to 5, Examples 1 to 4) were evaluated by visual observation according to the following criteria. did.
○: Pearl-like luster is observed.
×: Pearl-like luster is not observed.

The results are listed in Tables 1 and 2. As described in the table, pearl-like luster was observed in the emulsified compositions of Comparative Example 1 and Examples 1 to 4, but pearl-like luster was not observed in Comparative Examples 2 to 5.

(2-2) Confirmation of lamellar liquid crystal structure and α-gel structure Measurement was performed using an X-ray diffraction apparatus under the following conditions. Specifically, each emulsion composition (Comparative Examples 1 to 5, Examples 1 to 4) was set in an X-ray diffraction device, and the small angle region (2θ = 0 to 10 degrees) and wide angle region (2θ = 3 to 30 degrees) were measured. was measured.

[X-ray diffraction measurement conditions]
X-ray diffraction device: SmartLab (manufactured by Rigaku)
Line source: Cu line Voltage: 45kV
Measurement temperature: 20℃

(i) Confirmation of lamellar liquid crystal structure When the emulsified composition has a lamellar structure, the appearance of regular peaks in the small-angle region is observed by small-angle X-ray diffraction. Specifically, when a peak of d1:d2:d3:d4...=1:1/2:1/3:1/4... is observed, the existence of a lamellar liquid crystal structure can be confirmed.

FIG. 1(a) shows the measurement results of the emulsion composition of Example 1, and FIG. 1(b) shows the measurement results of the emulsion composition of Comparative Example 2. As can be seen from FIG. 1(a), the emulsion composition of Example 1 has lattice constants of 49.0 Å (Bragg angle 1.80°), 24.4 Å (Bragg angle 3.62°), and 16.2 Å (Bragg angle 5.46°). Peaks were observed at , 12.1 Å (Bragg angle 7.30°) and 9.7 Å (Bragg angle 9.14°), and the peak ratio was 1:1/2:1/3:1/4:1/5. As described above, since regular peaks were observed on the small angle side of the emulsified composition of Example 1, it was confirmed that the emulsified composition had a lamellar liquid crystal structure (evaluation: ○). As shown in Table 2, lamellar liquid crystal structures were similarly confirmed in the emulsified compositions of Examples 2 to 4. On the other hand, as shown in Table 1, no lamellar liquid crystal structure was observed in the emulsified compositions of Comparative Examples 1 to 5 (evaluation: ×).

(ii) Confirmation of α-gel structure The α-gel structure is a hexagonal crystal system in which the lipophilic groups are oriented at right angles to the plane of the hydrophilic base layer, and wide-angle X-ray diffraction revealed that the Bragg angle is 21 to 23. It is characterized by the appearance of a single sharp diffraction peak around °. Therefore, when the emulsified composition that is the test sample has an α-gel structure, a hexagonal-derived peak is observed around the Bragg angle of 21°.

FIG. 2(a) shows the measurement results of the emulsion composition of Example 1, and FIG. 2(b) shows the measurement results of the emulsion composition of Comparative Example 2. As can be seen from FIG. 2(a), the emulsified composition of Example 1 had a single sharp diffraction peak at a Bragg angle of 21.4° (lattice constant 4.14 Å). - It was confirmed that there was a gel structure (evaluation: ○). As shown in Table 2, α-gel structures were similarly confirmed in the emulsified compositions of Examples 2 to 4. On the other hand, as shown in Table 1, an α-gel structure was confirmed in Comparative Examples 1 to 5 (rating: ○), but a lamellar liquid crystal structure was not confirmed.

(2-3) Evaluation of skin barrier function The skin barrier function of each emulsion composition (Examples 1 to 4, Comparative Examples 1 to 5) was evaluated by the following method on 15 subjects.
1. Transepidermal water loss (TEWL) of the inner part of the upper arm (test site) is measured.
2. A 15 mm x 15 mm nonwoven fabric is impregnated with SDS (40 mg/mL or 4% aqueous solution) and attached to the inner side of the upper arm for 30 minutes. This process is repeated for 4 days.
3. Measure TEWL at the test site.
4. For one week, apply an appropriate amount (approximately 0.1 g) of the emulsified composition to the test site twice a day, after waking up in the morning and after taking a bath.
5. Measure TEWL at the test site.

Specifically, for each subject, 10 samples (5 samples each including 1 control sample) were prepared on the inner side of the left and right upper arms, and the TEWL before and after application was evaluated. The transepidermal water loss (TEWL) was measured twice using VAPO SCAN AS-VT100RS (Asahi Techno Lab Co., Ltd.), and the average value was taken as the transepidermal water loss.
As a statistical method, Wilcoxon's signed rank sum test (paired t-test) was used and evaluation was performed according to the following criteria.
○: There is a statistically significant difference (p<0.05)
×: No statistically significant difference (p>0.05)

The results are shown in Tables 1 and 2. As shown in Tables 1 and 2, barrier function was observed with statistically significant difference in the emulsion compositions of Examples 1 to 4 (evaluation: ○), but in the emulsion compositions of Comparative Examples 1 to 5. No barrier function was observed (rating: ×).

(2-4) Evaluation of feeling of use (spreading feeling, skin-conforming feeling, penetrating feeling) Approximately 0.5 g of each emulsified composition (Comparative Examples 1 to 5 and Examples 1 to 4) was applied to the face of 10 evaluation monitors. After applying the product, a questionnaire was conducted using a Visual Analogue Scale (hereinafter referred to as VAS) based on the following criteria, regarding the spread, texture, and penetration during application.
[The feeling of the cream spreading when applied]
“1” for poor elongation “10” for good elongation
[Feeling of the cream blending into the skin when applied]
“1”: Poor blending into the skin “10”: Good blending into the skin
[Feeling of cream penetration when applied]
“1” There is no feeling of penetration “10” There is a feeling of penetration

The evaluation results were compiled by averaging the questionnaire results and rounding to the first decimal place. The results are shown in Tables 1 and 2. As shown in Tables 1 and 2, the emulsified compositions of Examples 1 to 4 had good spreadability, skin conformability, and penetration feeling. On the other hand, the emulsified compositions of Comparative Examples 1 to 5 were all poor in spreadability, texture, and penetration.

Claims (4)

7-25% by mass of saturated or unsaturated fatty acids having 14-18 carbon atoms, 3-10% by mass of saturated or unsaturated fatty acid salts having 14-18 carbons, and saturated or unsaturated fatty acids having 14-18 carbons. Contains 1 to 8% by mass of monohydric alcohol ,
An emulsified composition having a pearl-like lustrous appearance,
In the X-ray structure analysis under the following X-ray diffraction measurement conditions, the lattice constants were 49.0 Å (Bragg angle 1.80°), 24.4 Å (Bragg angle 3.62°), 16.2 Å (Bragg angle 5.46°), 12.1 Å (Bragg An emulsion composition having a peak at 9.7 Å (Bragg angle 9.14°) and one peak in the Bragg angle region of 21 to 23°:
[X-ray diffraction measurement conditions]
X-ray diffraction device: SmartLab (manufactured by Rigaku)
Radiation source: Cu line
Voltage: 45kV
Measurement temperature: 20°C . In X-ray diffraction measurement,
It has the same X-ray diffraction pattern as the X-ray diffraction pattern described in FIG. 1(a) in the small angle region (2θ = 0 to 10 degrees),
The emulsified composition according to claim 1, which has the same X-ray diffraction pattern as the X-ray diffraction pattern shown in FIG. 2(a) in a wide-angle region (2θ = 3 to 30 degrees):
Figure 1(a)

Figure 2(a)

The emulsifying composition according to claim 1 or 2 , which is an O/W type emulsifying composition. The emulsified composition according to any one of claims 1 to 3 , which is an external preparation for skin.