JP7480952B2 - Stroke treatment support system - Google Patents

Description

The present invention relates to an angiography device and an angiography method used in a cerebral infarction treatment support system, and in particular to an angiography device and an angiography method that display fluoroscopic images.

Conventionally, medical image processing devices that generate superimposed images are known (see, for example, Patent Document 1).

The above-mentioned Patent Document 1 describes a medical image processing device equipped with a generation unit that generates a superimposed image by superimposing an image based on the subject's volume data on an X-ray image obtained by imaging the subject with X-rays. In Patent Document 1, the X-ray image is a fluoroscopic image, and the volume data is three-dimensional image data generated by reconstructing multiple projection images captured in advance by an X-ray diagnostic device, or three-dimensional image data of the same subject obtained by an X-ray CT device or MRI device. The superimposed image is also used in catheter treatment.

JP 2018-94409 A

Here, cerebral infarction is one of the diseases for which catheter treatment is performed. In treating cerebral infarction, the treatment method, such as the type of treatment device used, varies depending on the type of cerebral infarction. However, since it is difficult to determine the type of cerebral infarction from the fluoroscopic images and superimposed images generated as in Patent Document 1, doctors must separately obtain information regarding the cerebral infarction that the patient they are treating has.

This invention was made to solve the above problems, and one of the objects of this invention is to provide an angiography device that can obtain information about the cerebral infarction that a patient is suffering from during treatment.

In order to achieve the above object, an angiography apparatus in a first aspect of the present invention comprises an imaging unit including an X-ray source that irradiates a patient with radiation, and a detection unit that detects the X-rays irradiated from the X-ray source and transmitted through the patient and acquires a detection signal, an image processing unit that generates a fluoroscopic image of the patient based on the detection signal, a control unit that acquires genetic information of the patient including first information on whether the patient has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene, and a display unit that displays the fluoroscopic image and at least one of the first information and the second information of the genetic information during fluoroscopic imaging, wherein the genetic information includes at least the second information, and the second information includes at least any one of information on the type of cerebral infarction, information on the patient's cerebral blood vessels, and information indicating a treatment device that is recommended or not recommended for use in catheter treatment of cerebral infarction of the patient. In addition, in order to achieve the above-mentioned object, an angiography apparatus in a second aspect of the present invention comprises an imaging unit including an X-ray source that irradiates a patient with radiation, and a detection unit that detects the X-rays irradiated from the X-ray source and transmitted through the patient and acquires a detection signal, an image processing unit that generates a fluoroscopic image of the patient based on the detection signal, a control unit that acquires genetic information of the patient including first information on whether or not the patient has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene, and a display unit that displays the fluoroscopic image and at least one of the first information and the second information of the genetic information during fluoroscopic imaging, wherein the control unit is further configured to control the acquisition of information regarding the treatment position of cerebral infarction, and the display unit is further configured to display the information regarding the treatment position of cerebral infarction. In order to achieve the above object, an angiography apparatus according to a third aspect of the present invention includes an imaging unit including an X-ray source that irradiates radiation to a patient, and a detection unit that detects X-rays irradiated from the X-ray source and transmitted through the patient and acquires a detection signal, an image processing unit that generates a fluoroscopic image of the patient based on the detection signal, a control unit that acquires genetic information of the patient including first information on whether the patient has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene, and a display unit that displays the fluoroscopic image and at least one of the first information and the second information of the genetic information during fluoroscopic imaging, wherein the susceptibility gene for cerebral infarction includes a genetic polymorphism of RNF213p.R4810K. In order to achieve the above object, a fourth aspect of the present invention provides an angiography apparatus comprising: an imaging section including an X-ray source which irradiates a patient with radiation; and a detection section which detects the X-rays irradiated from the X-ray source and transmitted through the patient and acquires a detection signal; an image processing section which generates a fluoroscopic image of the patient based on the detection signal; a control section which acquires genetic information of the patient including first information on whether or not the patient has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene; and a display section which displays the fluoroscopic image and at least one of the first and second pieces of genetic information during fluoroscopic photography, wherein the control section is further configured to control the acquisition of vascular image data of the patient which has been photographed in advance, and the display section is configured to display an image in which the fluoroscopic image and the vascular image data are superimposed, and the genetic information, during fluoroscopic photography .

A method for angiography according to a fifth aspect of the present invention includes the steps of: an X-ray source irradiating a patient with X-rays; an image processing unit generating a fluoroscopic image; a control unit acquiring genetic information of the patient, the genetic information including at least one of first information indicating whether the patient has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene; and a display unit displaying the fluoroscopic image and the genetic information during fluoroscopic photography , the genetic information including at least the second information, the second information including at least any one of information regarding the type of cerebral infarction, information regarding the patient's cerebral blood vessels, and information indicating a treatment device that is recommended or not recommended for use in catheter treatment for cerebral infarction in the patient .

In the angiography apparatus according to the first to fourth aspects and the angiography method according to the fifth aspect, the above-mentioned configuration makes it possible to display genetic information related to the cerebral infarction of a patient being treated during fluoroscopic imaging, thereby providing an angiography apparatus capable of acquiring information related to the cerebral infarction that the patient has developed during brain treatment.

1 is a schematic diagram showing the overall configuration of a cerebral infarction treatment support system. FIG. 2 is a schematic diagram showing a configuration example of a detection device. 1A to 1F are diagrams for explaining the detection results of the detection device. FIG. 11 is a diagram for explaining second information. FIG. 1 is a schematic diagram showing types of treatment devices. FIG. 2 is a diagram showing examples of first information and second information. FIG. 1 is a diagram illustrating an example of the configuration of a cerebral infarction treatment support system. FIG. 1 is a flow chart for explaining the treatment process for acute cerebral infarction patients. FIG. 1 is a flow chart showing a method for supporting cerebral infarction treatment. 1 is a schematic diagram for explaining information linkage between each server and modality in a cerebral infarction treatment support system. FIG. 10A and 10B are schematic diagrams for explaining a process of transmitting first information and/or second information to an X-ray imaging apparatus. FIG. 11 is a flow diagram showing a process for transmitting first information and/or second information. FIG. 11 is a flow diagram showing a process of deleting first information. FIG. 11 is a flow diagram showing a process of transmitting second information and a CT image or an MRI image. FIG. 1 is a block diagram showing a configuration of an angiography apparatus. FIG. 1 is a diagram illustrating an example of an angiography apparatus. FIG. 13 is a diagram for explaining generation of a superimposed image. FIG. 13 is a diagram for explaining reconstruction of blood vessel image data. 4 is a flowchart showing the operation of the angiography apparatus.

The following describes an embodiment of the present invention with reference to the drawings.

The configuration of a cerebral infarction treatment support system 100 according to one embodiment will be described with reference to FIG. 1.

The cerebral infarction treatment support system 100 is a system that supports the diagnosis and treatment of acute cerebral infarction patients. The cerebral infarction treatment support system 100 is installed in a medical facility such as a hospital. The cerebral infarction treatment support system 100 is configured to provide doctors and others with information useful for diagnosis and treatment when diagnosing and treating acute cerebral infarction patients transported to the facility. The cerebral infarction treatment support system 100 can provide doctors and others with support information that is different from medical images, separate from medical images (X-ray images, CT images, MRI images, etc.) used in the diagnosis and treatment of acute cerebral infarction patients.

The cerebral infarction treatment support system 100 includes at least a gene detection device 10, an image control unit 20, and a display unit 30.

The detection device 10 is configured to measure a biological sample 2 collected from a patient 1 and generate first information 41 indicating whether or not the biological sample 2 contains a susceptibility gene related to cerebral infarction. The detection device 10 is installed, for example, in an examination room of a medical facility such as a hospital.

The biological sample 2 is a liquid collected from the patient 1 and contains at least the genomic DNA of the patient 1. The biological sample 2 includes, for example, specimens such as blood and saliva collected from the patient 1. The blood includes any of whole blood, plasma, and serum. The specimen may be tissues such as hair, nails, skin, and mucous membranes, or cells. In addition to the specimen, the biological sample 2 may include components used in the measurement of the detection device 10. The biological sample 2 may include, for example, a dissolving solution for eluting genes from the specimen, a reaction solution for amplifying genes, and the like. The reaction solution is designed to react specifically with susceptibility genes related to cerebral infarction, which is the detection target. In this specification, the biological sample is a concept that includes not only the specimen itself collected from the patient 1, but also a prepared sample prepared from the specimen and other components.

Susceptibility genes for cerebral infarction are significantly correlated with the likelihood of developing a particular type of cerebral infarction. In other words, the presence of a susceptibility gene for cerebral infarction in biological sample 2 indicates that the likelihood of developing the type of cerebral infarction associated with that susceptibility gene is significantly higher or lower than when the susceptibility gene is not present. Susceptibility genes for cerebral infarction can be specific gene mutations or gene polymorphisms. The first information 41 indicates whether or not such gene mutations or gene polymorphisms are present in the DNA in biological sample 2.

The first information 41 is information that can determine at least whether or not a susceptibility gene for cerebral infarction is present. The first information 41 can be, for example, binary information indicating either "there is a susceptibility gene for cerebral infarction (positive)" or "there is no susceptibility gene for cerebral infarction (negative)." The first information 41 can be information indicating whether there are two mutations or genetic polymorphisms that are susceptibility genes (mutant homozygous), one mutation (mutant/wild type heterozygous), or none (wild type homozygous).

In the cerebral infarction treatment support system 100, second information 42 related to the diagnosis or treatment of cerebral infarction can be generated based on first information 41 on whether or not a susceptibility gene for cerebral infarction exists. The second information 42 can be, for example, information indicating the type of cerebral infarction significantly associated with a susceptibility gene for cerebral infarction. In addition, for example, a patient having a susceptibility gene may exhibit a characteristic (trait) that makes the patient more likely to develop cerebral infarction. The characteristic that makes the patient more likely to develop cerebral infarction is, for example, a tendency for blood vessels in the brain to be thin or a tendency for blood vessel walls to be weak. The second information 42 is secondary information generated by taking into account other medical and scientific findings, with the first information 41 on whether or not a susceptibility gene for cerebral infarction exists as primary information. The second information 42 does not need to be generated by the detection device 10. The second information 42 can be generated by, for example, a computer or a server that can acquire the first information 41 from the detection device 10 via a network.

The image control unit 20 acquires at least one of the first information 41 generated by the detection device 10 and the second information 42 related to the susceptibility gene generated based on the first information 41. The image control unit 20 controls the display unit 30 to display at least one of the acquired first information 41 and second information 42. The image control unit 20 includes, for example, a computer configured to be able to communicate with the detection device 10 and the display unit 30.

Specifically, the image control unit 20 includes a receiving unit 21 and a video output unit 22. The receiving unit 21 receives at least one of the first information 41 generated by the detection device 10 and the second information 42 related to the susceptibility gene generated based on the first information 41. The receiving unit 21 can communicate directly with the detection device 10, for example, by wire or wirelessly. The receiving unit 21 can communicate with the detection device 10, for example, via a network. The receiving unit 21 does not need to receive information from the detection device 10, and it is sufficient that the receiving unit 21 can access, via the network, a device that stores the first information 41 generated by the detection device 10 and the second information 42 generated based on the first information 41.

The video output unit 22 outputs at least one of the received first information 41 and second information 42 to the display unit 30. The video output unit 22 is electrically connected to the display unit 30 by wire or wirelessly. FIG. 1 shows an example in which the image control unit 20 is installed outside the reading room 901 or the catheter room 902. In the example of FIG. 1, the image control unit 20 delivers at least one of the first information 41 and the second information 42 to the display unit 30 installed in the reading room 901 or the catheter room 902.

The display unit 30 is a monitor that displays information. The display unit 30 is placed in at least one of the catheter room 902 in which the vascular X-ray imaging device is placed and the image reading room 901 in which the image viewing terminal for radiological diagnostic images or MRI images is placed. The image control unit 20 outputs the received information (first information 41 and/or second information 42) to the display unit 30. The display unit 30 displays the information (first information 41 and/or second information 42) output from the image control unit 20.

In the cerebral infarction treatment support system 100, at least during treatment or diagnosis of the patient 1, information output from the image control unit 20 (at least one of the first information 41 and the second information 42) is displayed on the display unit 30.

For patients with acute cerebral infarction, diagnostic CT images or MRI images are taken by a CT device or MRI device in the hospital, and a diagnosis is made in an image reading room 901 in the hospital. In the cerebral infarction treatment support system 100, for example, when diagnosing patient 1, information received by the image control unit 20 is output to a display unit 30 installed in the image reading room 901. The image reading room 901 is a room in which an image viewing terminal (PC) for diagnostic images such as a radiation diagnostic device (X-ray device, CT device, etc.) or an MRI is located.

After diagnosis, in the stage of treating a cerebral infarction patient, for example, catheter treatment is performed on the infarcted area in the cerebral blood vessels. In the cerebral infarction treatment support system 100, for example, during catheter treatment of patient 1, information received by the image control unit 20 is output to the display unit 30 installed in the catheter room 902. The catheter room 902 is a room in which a vascular X-ray device used during catheter treatment is installed.

In this way, the display unit 30 is disposed in at least one of the catheter room 902 and the image reading room 901 in the hospital. The cerebral infarction treatment support system 100 may include other display units in addition to the display units 30 in the catheter room 902 and the image reading room 901. Such a display unit 30 may be, for example, a display unit of a portable information terminal such as a tablet terminal carried by a doctor or the like.

(Detection device)
The detection device 10 detects a susceptibility gene (detection target gene) for cerebral infarction from a biological sample 2. Detecting a susceptibility gene means detecting a specific base sequence in genomic DNA contained in the biological sample 2. The detection device 10 generates, as a detection result, first information 41 indicating whether or not the biological sample 2 has a susceptibility gene for cerebral infarction.

The number of susceptibility genes detected by the detection device 10 is not limited to one (one type). If the presence or absence of susceptibility genes related to multiple types of cerebral infarction significantly correlates with the possibility of developing any of the types of cerebral infarction, the first information 41 may represent the presence or absence of each of the multiple types of susceptibility genes.

The detection device 10, for example, amplifies the target gene of the biological sample 2. The detection device 10, for example, binds the target gene to a labeling substance. The detection device 10 detects a susceptibility gene related to cerebral infarction, for example, by detecting the labeling substance bound to the target gene. The labeling substance is not particularly limited as long as it generates a signal that can be detected by the detection device 10, but includes, for example, a fluorescent substance (fluorescent label). In this case, the detection device 10 irradiates the biological sample 2 with excitation light and detects the fluorescence generated from the labeling substance.

In the configuration example of FIG. 2, the detection device 10 is a gene amplification detection device that uses the PCR (Polymerase Chain Reaction) method to amplify and detect a target gene. The detection device 10 includes a container placement unit 11, a detection unit 12, a temperature adjustment unit 13, and a data processing unit 14.

The container mounting section 11 is configured to be capable of mounting a sample container 3 containing a biological sample 2. The sample container 3 is a light-transmitting reaction container, and may be a so-called PCR tube, a well plate, or the like.

The temperature adjustment unit 13 is configured to heat and/or cool the sample container 3 placed on the container placement unit 11 and adjust the temperature of the biological sample 2. The temperature adjustment unit 13 performs a thermal cycle process that periodically raises and lowers the temperature of the biological sample 2. The thermal cycle process amplifies the detection target gene (susceptibility gene for cerebral infarction) in the biological sample 2.

The detection unit 12 includes a light source 12a and a photodetector 12b. The light source 12a includes, for example, an LED (light emitting diode) element, and generates excitation light for the fluorescent probe contained in the biological sample 2. The light source 12a irradiates the biological sample 2 in the sample container 3 placed in the container mounting unit 11 with the excitation light. The fluorescent probe contained in the biological sample 2 is excited by the irradiation of the excitation light and generates fluorescence. The photodetector 12b is configured to detect the fluorescence generated from the fluorescent probe contained in the biological sample 2. The photodetector 12b outputs a detection signal according to the fluorescence intensity generated from the biological sample 2. The photodetector 12b includes, for example, a photomultiplier tube (PMT) or a photodiode.

In the configuration example of FIG. 2, the detection device 10 is configured to perform a gene amplification process on a biological sample 2 containing a specimen 2a containing blood or saliva collected from a patient 1 and a reaction solution 2c containing a component that suppresses the effects of inhibitory substances in the specimen 2a. In other words, the detection device 10 is a direct PCR device that performs a PCR process on a biological sample 2 prepared without performing a purification process to purify DNA from the specimen 2a. "Direct PCR" means that the PCR process is performed without going through a DNA purification process. The reaction solution 2c containing a component that suppresses the effects of inhibitory substances contains a PCR enzyme, a fluorescent probe, a primer, and a component that suppresses the effects of inhibitory substances in the specimen 2a. For example, it is preferable to use Ampdirect (registered trademark) buffer manufactured by Shimadzu Corporation as a component that suppresses the effects of inhibitory substances.

The detection device 10 is also configured to perform a real-time PCR method in which labeling processing is performed using a labeling substance during the gene amplification process. In other words, the detection device 10 does not perform labeling processing on the amplified product after gene amplification by PCR processing, but rather specifically binds a fluorescent probe to the detection target gene (a susceptibility gene related to cerebral infarction) during the gene amplification process by PCR processing.

In the configuration example of FIG. 2, first, a specimen 2a collected from a patient 1 is mixed with a cell lysis solution 2b. The mixture of the specimen 2a and the cell lysis solution 2b is mixed with a reaction solution 2c in a sample container 3. The reaction solution 2c contains a PCR enzyme, a fluorescent probe, a primer, and a component that suppresses the effects of inhibitory substances in the specimen 2a. In this way, a biological sample 2 is prepared. The component that suppresses the effects of inhibitory substances allows PCR processing to be performed without a DNA (deoxyribonucleic acid) purification process. The detection unit 12 detects fluorescence indicating the presence of the target gene during gene amplification by real-time PCR processing, and outputs a detection signal according to the fluorescence intensity to the data processing unit 14.

The data processing unit 14 is composed of a computer including a processor 14a such as a CPU (Central Processing Unit), a memory unit 14b that stores a program 15 for genetic analysis, and a communication unit 14c. The memory unit 14b includes a volatile and/or non-volatile storage device. The communication unit 14c includes a communication interface that can be connected to a network of a medical facility such as a hospital.

The processor 14a acquires the detection signal output from the detector 12. The processor 14a analyzes the detection signal by executing the program 15 stored in the memory 14b. The processor 14a generates, through the analysis, first information 41 indicating whether or not the biological sample 2 has a susceptibility gene related to cerebral infarction. The processor 14a causes the communication unit 14c to transmit the first information 41 to the server 50 via the network. The first information 41 may also be transmitted directly to the image controller 20.

The biological sample 2 collected from the patient 1 is assigned patient information 45. The patient information 45 includes unique identification information that identifies the patient 1. The detection device 10, for example, assigns the patient information 45 of the patient 1 from whom the biological sample 2 was collected to the first information 41.

In addition, while FIG. 2 shows an example in which a prepared sample in which the specimen 2a, the cell lysis solution 2b, and the reaction solution 2c are mixed is supplied to the detection device 10 as the biological sample 2, instead, for example, a biological sample 2 containing only the specimen 2a may be supplied to the detection device 10. In this case, the detection device 10 may be configured to include a mechanism for dispensing the cell lysis solution 2b and the reaction solution 2c into the sample container 3 containing the biological sample 2, and to prepare a sample for measurement within the detection device 10.

The susceptibility gene for cerebral infarction may be a single nucleotide polymorphism (SNP) in the base sequence of a specific gene. Methods for detecting SNP include, for example, RFLP (restriction fragment length polymorphism), PCR-SSCP (single-stranded DNA conformation polymorphism analysis), ASO (allele specific oligonucleotide) hybridization, sequencing, ARMS (amplification refracting mutation system), denaturing gradient gel electrophoresis, RNAse A cleavage, DOL (dye-labeled oligonucleotide ligation), TaqMan PCR, primer extension, and Invader. The detection device 10 may be a device capable of implementing any of the above detection methods, in addition to the configuration example shown in FIG. 2.

(Susceptibility genes for cerebral infarction)
Susceptibility genes for cerebral infarction include, for example, the RNF213 p.R4810K gene polymorphism.

RNF213 (Ring finger protein 213) (GenBank accession number NM_001256071.1) is located in the human chromosomal region 17q25.3.

The RNF213 p.R4810K gene polymorphism is a single nucleotide polymorphism (SNP) of 73097 G>A in the nucleotide sequence represented by SEQ ID NO:2. The detection device 10 detects the SNP of 73097 G>A in the biological sample 2.

SEQ ID NO:2 is a partial nucleotide sequence of human chromosome 17 DNA containing the mysterin gene and genes in its surrounding region [FLJ3520, NPTX1, CARD14, and Raptor (KIAA1303)], and corresponds to nucleotides 43560001 to 43795000 of Contig #NT010783.15 registered with NCBI.

In addition to the SNP at position 73097 (73097 G>A) which is G or A, the nucleotide sequence represented by SEQ ID NO:2 may also include a SNP at position 4766 (4766 T>C) which is T or C, a SNP at position 120764 (120764 G>A) which is G or A, a SNP at position 152917 (152917 G>A) which is G or A, and a SNP at position 232102 (232102 G>A) which is G or A.

In this specification, the position of a SNP is described based on the position of the nucleotide in the nucleotide sequence represented by SEQ ID NO:2. For example, "SNP at position 73097" means the SNP at the nucleotide at position 73097 in the nucleotide sequence represented by SEQ ID NO:2. When describing "73097 G>A", the major allele base (G in this case) is described before the ">" symbol, and the minor allele base (A in this case) is described after it.

In addition, in this specification, nucleotide sequences are described as DNA sequences unless otherwise specified, but when the polynucleotide is RNA (ribonucleic acid), thymine (T) should be read as uracil (U) as appropriate. A polynucleotide may contain any additional sequence in addition to a continuous partial sequence of the nucleotide sequence represented by SEQ ID NO:2 or its complementary sequence.

The inventors' research has revealed that the RNF213 p. R4810K polymorphism increases the risk of ischemic stroke (i.e., atherothrombotic cerebral infarction) due to aortic atherosclerosis. The inventors have filed a patent application based on this finding. The patent applications filed by the inventors are numbered JP 2018-233549 and PCT/JP2018/045915, and the entire disclosures of these applications are incorporated herein by reference.

Figures 3(A) to 3(F) show examples of detection results of the RNF213 p. R4810K gene polymorphism using the detection device 10. In each of the graphs in Figures 3(A) to 3(F), the vertical axis indicates the signal intensity (fluorescence intensity) of the detection signal from the detection device 10, and the horizontal axis indicates the number of cycles of the PCR process in the detection device 10.

Figure 3 (A) shows the detection result of the wild-type positive control of the RNF213 gene. Figure 3 (B) shows the detection result of the mutant positive control of the RNF213 gene. The wild-type means a base sequence in which the p. R4810K gene polymorphism does not exist, and the mutant type means a base sequence in which the p. R4810K gene polymorphism exists. The positive control is a synthesis of DNA having each of the wild-type and mutant sequences. Figure 3 (C) shows the detection result of a positive control of a heterozygote in which one allele of RNF213 is wild-type and the other is mutant. Figure 3 (D) shows the detection result using blood collected from a subject. Figure 3 (E) shows the detection result using saliva collected from a subject. Figure 3 (F) shows the detection result of a negative control for verifying the judgment result of the detection device 10. The negative control is a sample that does not contain either the wild-type or mutant type of the RNF213 gene.

In FIG. 3(A), the intensity of the fluorescent signal (referred to as wild-type signal 16) generated from the fluorescent probe that specifically binds to the wild-type of the RNF213 gene increases, while the intensity of the fluorescent signal (referred to as mutant signal 17) generated from the fluorescent probe that specifically binds to the mutation of the RNF213 gene does not change. In FIG. 3(B), the intensity of the wild-type signal 16 does not change, and the intensity of the mutant signal 17 increases. In FIG. 3(C), the intensities of both the wild-type signal 16 and the mutant signal 17 increase. Therefore, it is possible to determine the presence or absence of the RNF213 p.R4810K gene polymorphism based on the change in the intensity of the mutant signal 17 from the detection results of the detection device 10.

Figures 3(D) and 3(E) confirm that the blood and saliva samples actually collected from the subjects also showed changes in signal intensity similar to those of the positive control. Figure 3(F) confirms that there was no nonspecific amplification, and that specific amplification and labeling of the target gene was achieved.

From the above, the data processing unit 14 shown in FIG. 2 determines the presence or absence of a susceptibility gene for cerebral infarction (RNF213 p.R4810K gene polymorphism) based on the change in intensity of the mutant signal 17. The data processing unit 14 creates first information 41 according to the determination result. That is, the data processing unit 14 generates first information 41 indicating the presence of a susceptibility gene for cerebral infarction when the intensity of the signal (mutant signal 17) derived from the marker substance for the susceptibility gene for cerebral infarction increases in the detection result. The data processing unit 14 generates first information 41 indicating the absence of a susceptibility gene for cerebral infarction when the intensity of the signal (mutant signal 17) derived from the marker substance for the susceptibility gene for cerebral infarction does not increase in the detection result.

As a criterion for determining whether or not a susceptibility gene is present in the detection results, for example, a threshold value is set for the signal intensity. The data processing unit 14 obtains, for example, the difference value between the signal intensity at the start of the PCR process and the signal intensity at the end of the PCR process, and determines that a susceptibility gene is present if the obtained difference value exceeds the threshold value. It may also be determined that a susceptibility gene is present simply if the signal intensity of the mutant signal 17 exceeds the threshold value.

The susceptibility gene for cerebral infarction may be other than the RNF213 p. R4810K gene polymorphism. Recent genetic research suggests a correlation between cardiogenic cerebral infarction and related genes PITX2 (human chromosome region 4q25) and ZFHX3 (human chromosome region 16q22). A correlation between lacunar infarction and related genes such as ALDH2 (human chromosome region 12q24) has been suggested. The susceptibility gene for cerebral infarction may include one or more of these genes. The susceptibility gene for cerebral infarction may be any gene that shows a significant correlation with a specific cerebral infarction, and is not limited to the above-mentioned ones.

(Second information)
Next, the second information 42 will be described. In the example shown in Fig. 4, the second information 42 includes at least one of information 42a on the type of cerebral infarction, information 42b on the cerebral blood vessels of the patient 1, and information 42c (hereinafter referred to as "device information 42c") indicating a treatment device whose use is recommended or not recommended in the cerebral infarction catheter treatment of the patient 1. The second information 42 is generated, for example, in the form of a message (text) for the user.

The information 42a on the type of cerebral infarction is information indicating the type of cerebral infarction that is significantly correlated with the susceptibility gene whose presence or absence has been detected by the first information 41. The types of cerebral infarction are classified into three types: cardiogenic cerebral embolism, lacunar infarction, and atherothrombotic cerebral infarction. The presence of a susceptibility gene indicates, for example, that the likelihood of developing any type of cerebral infarction is significantly high or low. The information 42a on the type of cerebral infarction may be a message indicating the type of cerebral infarction that is significantly high or low in likelihood of developing.

Information 42b about patient 1's cerebral blood vessels is information about the morphology or properties of patient 1's cerebral blood vessels that is inferred based on the presence or absence of a susceptibility gene. Information 42b about patient 1's cerebral blood vessels may be, for example, a message indicating that, if a susceptibility gene is present, the cerebral blood vessels tend to be thick or thin. Information 42b about patient 1's cerebral blood vessels may be, for example, a message indicating that, if a susceptibility gene is present, the cerebral blood vessels tend to be strong (resistant to injury) or weak (easily injured).

Device information 42c is information that indicates the type or shape of the treatment device that is an option for catheter treatment.

Therapeutic devices used in catheter treatment of cerebral infarction include a thrombus retrieval device 5a, a thrombus suction device 5b, and a percutaneous transluminal angioplasty device 5c, all of which are shown in Figure 5. The thrombus retrieval device 5a has a coiled wire for entangling and retrieving thrombi. The thrombus suction device 5b is hollow tubular and is configured to remove thrombi by suctioning them into the device. The percutaneous transluminal angioplasty device 5c includes a balloon catheter and a stent.

The device information 42c may be, for example, a message indicating a treatment device for which use is recommended or not recommended, among a thrombus retrieval device 5a, a thrombus aspiration device 5b, and a percutaneous transluminal angioplasty device 5c.

For example, the presence of the RNF213 p.R4810K gene polymorphism significantly increases the likelihood of developing atherothrombotic cerebral infarction. In addition, when this gene polymorphism is present, the relatively large blood vessels in the brain, which are the site of infarction due to atherothrombotic cerebral infarction, tend to be thinner than the same site in the group that does not have this gene polymorphism. Furthermore, since even the relatively large blood vessels in the brain tend to be thinner than normal, the use of a thrombus retrieval device that is likely to come into contact with blood vessels may cause re-occlusion due to endothelial damage in the occluded blood vessel.

For this reason, as an example, as shown in FIG. 6, when the first information 41 indicates the presence of the RNF213 p. R4810K gene polymorphism, the information 42a on the type of cerebral infarction includes a message that the type of cerebral infarction suffered by the patient 1 from whom the biological sample 2 was collected is "highly likely to be atherothrombotic cerebral infarction." The information 42b on the cerebral blood vessels of the patient 1 includes a message that "the cerebral blood vessels of the patient 1 from whom the biological sample 2 was collected tend to be thin." The device information 42c includes a message that "the use of the thrombus retrieval device 5a is not recommended" and/or a message that "the use of the thrombus suction device 5b or the percutaneous transluminal angioplasty device 5c is recommended." The device information 42c may include a message that "the use of a treatment device with a smaller diameter than usual is recommended."

In the configuration example of FIG. 2, the cerebral infarction treatment support system 100 includes a server 50 that is communicatively connected to the detection device 10 and the image control unit 20 and stores the first information 41. The server 50 is configured to generate the second information 42 based on the first information 41, as shown in FIG. 4.

As described above, the server 50 has a second information generation table 51 for generating the second information 42 according to the content of the first information 41 (presence/absence of a susceptibility gene). The second information generation table 51 is a data table that records the presence or absence of a specific susceptibility gene and the content of the second information 42 to be generated corresponding to the presence or absence of the susceptibility gene in association with each other. When the server 50 acquires the first information 41 from the detection device 10, the server 50 generates the second information 42 by referring to the second information 42 corresponding to the content of the first information 41 from the second information generation table 51. The second information 42 is associated with the first information 41 or the patient information 45 assigned to the first information 41. The patient information 45 assigned to the first information 41 may also be assigned to the second information 42.

The second information 42 may be generated by a server 50 in the hospital or may be generated by a cloud server via the Internet. The detection device 10 may generate the second information 42 together with the first information 41. The server 50 includes, for example, at least one of a radiology information system server and a medical image management system server connected to a network in the hospital. Here, the radiology information system server is called a RIS (Radiology Information Systems) server 52 (see FIG. 7), and is a server that executes the processing of a system that mainly performs examinations using radiation equipment and manages the examination results. The medical image management system server is a server that collects and records medical image data, and is also called a DICOM server 53 (see FIG. 7) because it handles medical image data that conforms to the DICOM standard, which is a standard.

The image control unit 20 (see FIG. 1) is configured to receive at least the second information 42 from the server 50, for example. The image control unit 20 outputs at least the received second information 42 to the display unit 30 for display. The image control unit 20 may receive both the first information 41 and the second information 42 and display them on the display unit 30. The image control unit 20 may display only the first information 41 on the display unit 30, in which case the cerebral infarction treatment support system 100 does not need to generate the second information 42.

(Example of the configuration of a cerebral infarction treatment support system)
7 shows a more specific example of the configuration of the cerebral infarction treatment support system 100. The cerebral infarction treatment support system 100 can be configured as a part or the whole of an intra-hospital network.

Radiation equipment such as a CT scanner 101 and an MRI scanner 102, and a detection device 10 are connected to the intra-hospital network. Various portable terminals 103 such as tablet-type information terminals, and various servers such as a RIS server 52 and a DICOM server 53 are connected to the intra-hospital network. In addition, a vascular X-ray imaging device 70 installed in the catheterization room 902, and an image viewing terminal 80 installed in the image reading room 901 are connected to the intra-hospital network.

The catheter room 902 is equipped with a vascular X-ray imaging device 70, a catheter device 104, and the like. The treatment device 5 to be used during treatment is prepared. The vascular X-ray imaging device 70 is an angiography device that performs fluoroscopic imaging of blood vessels. The vascular X-ray imaging device 70 detects X-rays emitted from an X-ray source using an X-ray detector to create an image. The vascular X-ray imaging device 70 includes a first control device 71 that controls the device, and a first display unit 72 that displays the captured X-ray image. The vascular X-ray imaging device 70 performs fluoroscopic imaging of the catheter and treatment device 5 introduced into the blood vessel during catheter treatment in a moving image format, and displays the images on the first display unit 72. Details of the vascular X-ray imaging device 70 will be described later.

The image viewing terminal 80 installed in the image reading room 901 is, for example, a PC (personal computer), and includes a second control device 81 constituting the PC body, and a second display unit 82. In the image reading room 901, a doctor or the like uses the image viewing terminal 80 to view medical images of the patient 1, and identifies the location of the thrombus in the cerebral infarction patient 1, and determines the diagnosis and treatment plan. The medical images include CT images taken by a CT device 101 and MRI images taken by an MRI device.

In the configuration example of FIG. 7, the image control unit 20 includes a first control device 71 provided in the vascular X-ray imaging device 70 installed in the catheter room 902. The first control device 71 includes a receiving unit 21 and a video output unit 22. The display unit 30 includes a first display unit 72 installed in the catheter room 902 and displaying an X-ray image 73 of the vascular X-ray imaging device 70.

Specifically, the first control device 71 is configured to output at least one of the first information 41 and the second information 42 received and an X-ray image 73 of the patient 1 taken by the vascular X-ray device 70 to the first display unit 72 during catheter treatment of the patient 1 in the catheter room 902. As a result, the information received by the image control unit 20 (at least one of the first information 41 and the second information 42) is displayed during treatment of the patient 1 in the catheter room 902.

In the configuration example of FIG. 7, the image control unit 20 includes a second control device 81 provided in the image viewing terminal 80 installed in the reading room 901. The second control device 81 includes a receiving unit 21 and a video output unit 22. The display unit 30 includes a second display unit 82 installed in the reading room 901 and performing screen display of the image viewing terminal 80.

Specifically, the second control device 81 is configured to receive at least one of the first information 41 and the second information 42 and the CT image 6 or the MRI image 7 of the patient 1 during diagnosis of the patient 1 in the reading room 901, and output them to the second display unit 82. As a result, during diagnosis of the patient 1 in the reading room 901, the information received by the image control unit 20 (at least one of the first information 41 and the second information 42) is displayed.

As described above, the first information 41 and the second information 42 are either assigned with the patient information 45 or are recorded in the server 50 (RIS server 52 or DICOM server 53) in association with the patient information 45. In addition, the X-ray image 73, CT image 6, and MRI image 7 taken by the vascular X-ray imaging device 70 are assigned with the patient information 45 at the time of capture. These images and the first information 41 and second information 42 can be identified as having been obtained from the same patient 1 based on the patient information 45.

Therefore, in the above configuration example, the image control unit 20 receives an image of the patient 1 to which the patient information 45 has been assigned, and outputs the image having the same patient information 45 and at least one of the first information 41 and the second information 42 to the display unit 30. The image of the patient 1 includes any one of the X-ray image 73 from the vascular X-ray imaging device 70, the CT image 6, and the MRI image 7, and may also include other medical images.

The cerebral infarction treatment support system 100 may be configured to provide at least one of the first information 41 and the second information 42 to a doctor or the like after treatment of the cerebral infarction patient 1, even during postoperative evaluation or to check the progress of treatment.

(Patient treatment flow)
Next, the flow of treatment for the acute cerebral infarction patient 1 will be briefly described with reference to FIG.

First, Patient 1, who is suspected to have suffered a cerebral infarction, is brought to the hospital as an emergency patient.

After the patient is admitted, patient information 45 and triage information are input to the hospital network system. The triage information is information indicating the priority of the treatment order determined based on the severity of the patient 1. In addition, a sample 2a is obtained from the patient 1.

In an imaging room, a CT image 6 or an MRI image 7 is taken of the patient 1 by a CT device 101 or an MRI device 102. In parallel with the imaging of the patient 1, a biological sample 2 is prepared from a specimen 2a and supplied to a detection device 10. In parallel with the imaging of the patient 1, the cerebral infarction treatment support system 100 detects susceptibility genes by the detection device 10.

Next, in the image reading room 901, a diagnosis is made on the patient 1 based on the captured CT image 6 or MRI image 7. The image control unit 20 displays at least one of the first information 41 and the second information 42 together with an image of the patient 1 based on the patient information 45 (see FIG. 6). Based on the provided information, the doctor or the like diagnoses that the patient 1 has developed a cerebral infarction, identifies the site of the thrombus, and determines a treatment plan.

For example, a first procedure is performed according to the treatment plan. The first procedure is administration of a thrombolytic agent to patient 1. If necessary, for example, when administration of the thrombolytic agent does not sufficiently improve blood flow in the cerebral blood vessels, a second procedure is performed. The second procedure is catheter therapy.

During catheter treatment, the image control unit 20 displays at least one of the first information 41 and the second information 42 together with an X-ray image 73 (see FIG. 7) of the patient 1 based on the patient information 45. The doctor in charge of treatment selects a treatment device 5 based on the provided information and performs catheter treatment while referring to the X-ray image 73 inside the blood vessel.

(Operation of cerebral infarction treatment support system)
Next, the operation of the cerebral infarction treatment support system 100 will be described with reference to Fig. 9. The cerebral infarction treatment support method of this embodiment is carried out by the cerebral infarction treatment support system 100. Note that Fig. 2 is to be referred to for the detection device 10, and Figs. 4 and 6 are to be referred to for the first information 41, the second information 42, and the patient information 45.

In step 91, the detection device 10 measures the biological sample 2 collected from the patient 1 and generates first information 41 indicating whether or not the biological sample 2 contains a susceptibility gene related to cerebral infarction.

In step 92, the detection device 10 assigns the patient information 45 of the patient 1 to the first information 41 generated from the biological sample 2 collected from the patient 1 who has been brought in as an emergency patient.

In step 93, the second information 42 can be generated based on the first information 41. If the second information 42 is not to be displayed, step 93 is not necessary.

In step 94, the receiving unit 21 of the image control unit 20 (see Figures 1 and 7) receives at least one of the first information 41 and the second information 42.

In step 95, the video output unit 22 (see Figures 1 and 7) of the image control unit 20 outputs at least one of the first information 41 and the second information 42 received by the image control unit 20 to the display unit 30 for display. The image control unit 20 receives the first information 41 of the patient 1 from whom the biological sample 2 was collected based on the patient information 45, and outputs it to the display unit 30 (see Figures 1 and 7).

The first information 41 and/or the second information 42 may be displayed only at the time of treatment or diagnosis of the patient 1. In particular, treatment of the acute cerebral infarction patient 1 needs to be performed within a short period of time. Therefore, if it takes time to detect susceptibility genes, it is possible that generation of the first information 41 has not been completed by the time the patient 1 is diagnosed. Even in this case, in this embodiment, the received information is displayed on the display unit 30 together with the patient information 45 at least until the time of treatment of the patient 1. The treating doctor can select the treatment device 5 with reference to the first information 41 and/or the second information 42.

(Another example of the configuration of the cerebral infarction support system)
Next, a cerebral infarction treatment support system 200 according to another configuration example will be described with reference to Figures 10 and 11. The cerebral infarction treatment support system 200 implements the cerebral infarction treatment support method of this embodiment .

In the configuration example of FIG. 10, the cerebral infarction treatment support system 200 includes a detection device 210, a server 250, and a modality 105. The server 250 is an example of the "management unit" in the claims.

The server 250 includes a RIS server 252, a DICOM server 253, and a hospital information system server connected to the network within the hospital. Here, the hospital information system server is called a HIS (Hospital Information Systems) server 254, and includes, for example, an automatic reception system, an electronic medical record management system, a medical accounting system, a medical appointment system, a pharmacy management system, and the like. The HIS server 254 is configured to store patient information 245. Note that the RIS server 252 and the DICOM server 253 have the same configuration as the RIS server 52 (see FIG. 7) and the DICOM server 53 (see FIG. 7), respectively, and therefore a detailed description is omitted.

The modality 105 includes an X-ray imaging device 270 (see FIG. 11), an image viewing terminal 80 (see FIG. 11), a CT device 101 (see FIG. 7), and an MRI device 102 (see FIG. 7). In this specification, "modality" refers to these medical imaging devices collectively. Note that the X-ray imaging device 270 has a similar configuration to the vascular X-ray imaging device 70, and therefore a detailed description thereof is omitted. Also, the X-ray imaging device 270 is an example of "device used to treat a patient" as defined in the claims.

(Gene-related information)
The detection device 210 measures a biological sample 2 collected from a patient 1, and generates gene-related information 240 related to susceptibility genes for cerebral infarction. The gene-related information 240 further includes first information 241 indicating whether or not the biological sample 2 has a susceptibility gene for cerebral infarction, and second information 242 related to the susceptibility gene generated based on the first information 241.

(First information and second information)
The server 250 is configured to generate second information 242 related to susceptibility genes based on the first information 241 included in the gene-related information 240 generated by the detection device 210. The first information 241 is the same as the first information 41 (see FIG. 4). That is, the first information 241 includes patient information 245 and information on the presence/absence of gene polymorphism. The patient information 245 is the same as the patient information 45 (see FIG. 4) and includes identification information 245a. The identification information 245a is unique information that can identify the patient 1. The identification information 245a includes, for example, a patient identification number. The second information 242 is the same as the second information 42 (see FIG. 4). That is, the second information 242 includes at least one of information 42a related to the type of cerebral infarction, information 42b related to the cerebral blood vessels of the patient 1, and information 42c indicating a treatment device whose use is recommended or not recommended in the cerebral infarction catheter treatment of the patient 1.

In the example of FIG. 10, the HIS server 254 transmits an examination request 201 to the detection device 210. When transmitting the examination request 201, the HIS server 254 also transmits the identification information 245a of the patient 1 to be examined.

The detection device 210 receives the inspection request 201, performs the inspection, and generates the first information 241. The detection device 210 also links the generated first information 241 to the identification information 245a transmitted together with the inspection request 201. The detection device 210 transmits the first information 241 linked to the identification information 245a to the HIS server 254.

The HIS server 254 manages the first information 241 transmitted from the detection device 210. Note that managing the first information 241 includes storing the first information 241 in the HIS server 254. In addition, managing the first information 241 includes transmitting the first information 241 to the X-ray imaging device 270, etc.

The server 250 is configured to generate second information 242 related to susceptibility genes based on the first information 241 included in the gene-related information 240 generated by the detection device 210.

In this embodiment, the server 250 is configured to store the identification information 245a of the patient 1. The server 250 is communicably connected to the detection device 210. The server 250 is configured to associate the set identification information 245a of the patient 1 with the stored identification information 245a of the patient 1, and to associate and manage at least one of the stored identification information 245a of the patient 1 or the patient information 245 of the patient 1 related to the identification information 245a of the patient 1 with the gene-related information 240. In this embodiment, the process of setting the identification information 245a of the patient 1 in the gene-related information 240 is executed by the detection device 210 that generates the gene-related information 240.

In this embodiment, the server 250 is configured to associate at least one of the first information 241 and the second information 242 with the patient information 245 of the patient 1 by associating the first information 241 and the second information 242 with the identification information 245a that identifies the patient 1 (see FIG. 1), thereby associating and managing the first information 241 and the second information 242 with the patient information 245 of the patient 1. In this embodiment, the HIS server 254 is configured to associate the second information 242 with the patient information 245. The HIS server 254 is also configured to store the second information 242 in a state associated with the patient information 245.

The HIS server 254 also transmits an imaging request 202 for patient 1 to the RIS server 252. The RIS server 252 transmits the imaging request 202 to the modality 105 based on the received imaging request 202. Specifically, when a request to acquire a CT image 6 for patient 1 is transmitted, the RIS server 252 transmits the imaging request 202 to the CT device 101. When a request to acquire an MRI image 7 for patient 1 is transmitted, the RIS server 252 transmits the imaging request 202 to the MRI device 102. Here, the imaging request 202 may include patient information 245.

The modality 105 (here, the CT device 101 or the MRI device 102) that receives the imaging request 202 performs imaging of the patient 1. After imaging is completed, the modality 105 transmits the acquired image (CT image 6 or MRI image 7) to the DICOM server 253.

The DICOM server 253 stores the transmitted image (CT image 6 or MRI image 7). Here, by associating the patient information 245 included in the imaging request 202 with the patient information 245 stored in the HIS server 254, it is possible to store at least one of the first information 241 and the second information 242 stored in the HIS server 254 and the patient information 245 in the header of the transmitted image. In addition, the DICOM server 253 transmits imaging completion information 203 indicating that imaging of the image (CT image 6 or MRI image 7) has been completed to the HIS server 254.

The HIS server 254 that receives the shooting completion information 203 stores the fact that shooting for the transmitted shooting request 202 has been completed.

Modality 105 also obtains first information 241, second information 242, and an image (CT image 6 or MRI image 7) by sending requests (requests 204, 206, and 207) to server 250.

Specifically, when diagnosing cerebral infarction, the image viewing terminal 80 is configured to acquire an image (CT image 6 or MRI image 7) from the DICOM server 253 by being operated by a doctor or the like. The image viewing terminal 80 is operated by a doctor or the like to transmit an image transmission request 204 to the DICOM server 253. The DICOM server 253 that receives the image transmission request 204 transmits an image (CT image 6 or MRI image 7) to the image viewing terminal 80. For example, the doctor or the like creates a diagnostic report 205 regarding the stenosis site, etc., based on the image (CT image 6 or MRI image 7) transmitted to the image viewing terminal 80. The created diagnostic report 205 is transmitted to the DICOM server 253, for example. The DICOM server 253 stores the transmitted diagnostic report 205.

When treating cerebral infarction, the X-ray imaging device 270 also transmits requests 206 and 207 to the server 250 in order to obtain at least one of the first information 241 and the second information 242, and an image (CT image 6 or MRI image 7). The X-ray imaging device 270 obtains the information and image transmitted from the server 250 in response to requests 206 and 207.

Now, referring to FIG. 11, we will explain the configuration in which the server 250 transmits at least one of the first information 241 and the second information 242, and an image (CT image 6 or MRI image 7) to the X-ray imaging device 270.

As shown in FIG. 11, the X-ray imaging device 270 is configured to be operated by a doctor or the like to transmit a request 206 to the RIS server 252 to acquire at least one of the first information 241 and the second information 242. When transmitting the transmission request 206, the X-ray imaging device 270 also transmits the identification information 245a.

The RIS server 252 that receives the request 206 transmits the request 206 and the identification information 245a to the HIS server 254.

The HIS server 254 that receives the request 206 transmits at least one of the first information 241 and the second information 242 linked to the identification information 245a to the RIS server 252 based on the received identification information 245a.

The RIS server 252 transmits at least one of the received first information 241 and second information 242 to the X-ray imaging device 270.

The X-ray imaging device 270 also transmits a transmission request 207 for an image (CT image 6 or MRI image 7) to the DICOM server 253 based on the operation of a doctor or the like. When transmitting the transmission request 207, the X-ray imaging device 270 also transmits the identification information 245a.

The DICOM server 253 that receives the transmission request 207 identifies the image of patient 1 (CT image 6 or MRI image 7) from among the multiple stored images (CT image 6 or MRI image 7) based on the identification information 245a. The DICOM server 253 transmits the identified image (CT image 6 or MRI image 7) to the X-ray imaging device 270 via the RIS server 252.

That is, the server 250 is configured to associate the second information 242 with the CT image 6 or MRI image 7 of the patient 1 using the identification information 245a. The server 250 is also configured to transmit at least one of the first information 241 and the second information 242 to the X-ray imaging device 270. In this embodiment, the server 250 is configured to transmit the CT image 6 or MRI image 7 of the patient 1 and the second information 242 to the X-ray imaging device 270 based on the request 206 and the request 207 from the X-ray imaging device 270.

In this embodiment, the RIS server 252 transmits at least one of the first information 241 and the second information 242 to the X-ray imaging device 270. However, if at least one of the first information 241 and the second information 242 is stored in the CT image 6 or MRI image 7 of the patient 1 stored in the DICOM server 253, it is not necessary for the RIS server 252 to transmit at least one of the first information 241 and the second information 242. In this case, at least one of the first information 241 and the second information 242 can be stored in the header of the CT image 6 or MRI image 7 of the patient 1.

(Transmission process of first information and/or second information)
Next, a process in which the server 250 generates the first information 241 and the second information 242 will be described with reference to FIG.

In step 301, the detection device 210 measures the biological sample 2 collected from the patient 1 and generates gene-related information 240 related to susceptibility genes related to cerebral infarction. The detection device 210 transmits the generated gene-related information 240 to the server 250.

In step 302, the detection device 210 sets patient 1's identification information 245a in the gene-related information 240.

In step 303, the server 250 associates the set patient 1 identification information 245a with the patient identification information 245a stored in the server 250.

In step 304, the server 250 manages at least one of the identification information 245a of patient 1 stored in the server 250 or the patient information 245 of patient 1 related to the identification information 245a of patient 1 in association with the gene-related information 240. The gene-related information 240 includes first information 241 indicating whether the biological sample 2 has a susceptibility gene for cerebral infarction or not, and second information 242 related to the susceptibility gene generated based on the first information 241. In this embodiment, the server 250 manages at least one of the identification information 245a of patient 1 stored in the server 250 or the patient information 245 of patient 1 related to the identification information 245a of patient 1 in association with at least one of the first information 241 and the second information 242. Specifically, the server 250 manages the second information 242 in association with the patient information 245.

In step 305, the server 250 determines whether or not there is a request 206 from the X-ray imaging device 270 to transmit the first information 241 and/or the second information 242. If there is a request 206, the process proceeds to step 306. If there is no request 206, the process ends.

In step 306, the server 250 transmits at least one of the first information 241 and the second information 242 to the X-ray imaging device 270. Then, the process ends.

(Deletion of first information)
In this embodiment, the HIS server 254 is configured to delete the first information 241 immediately after associating the second information 242 with the patient information 245, or after a preset period has elapsed, or based on information 208 (see FIG. 10 ) indicating the end of treatment from the X-ray imaging device 270, and to store the second information 242 in a state associated with the patient information 245. In this embodiment, the HIS server 254 is configured to delete the first information 241 based on the information 208 indicating the end of treatment from the X-ray imaging device 270, after associating the second information 242 with the patient information 245.

Next, referring to FIG. 13, the deletion process of the first information 241 when deleting the first information 241 based on information 208 (see FIG. 10) indicating the end of treatment will be described.

In step 401, the server 250 determines whether or not information 208 indicating the end of treatment has been transmitted from the X-ray imaging device 270. If the server 250 receives information 208 indicating the end of treatment from the X-ray imaging device 270, the process proceeds to step 402. If the server 250 does not receive information 208 indicating the end of treatment from the X-ray imaging device 270, the server 250 repeats the process of step 401.

In step 402, the server 250 deletes the first information 241. The process then ends.

(Transmission of second information and CT image or MRI image)
Next, a process in which the server 250 transmits the second information 242 and the CT image 6 or the MRI image 7 of the patient 1 to the X-ray imaging device 270 will be described with reference to FIG.

In step 410, the DICOM server 253 determines whether or not there is a request 207 to send an image (CT image 6 or MRI image 7) from the X-ray imaging device 270. If there is a request to send an image, the process proceeds to step 411. If there is no request to send an image, the process of step 410 is repeated. When the request to send 207 is sent from the X-ray imaging device 270, the identification information 245a is also sent.

Next, in step 411, the DICOM server 253 (server 250) associates the second information 242 with the CT image 6 or MRI image 7 of patient 1 using the identification information 245a. Specifically, upon receiving the transmission request 207, the DICOM server 253 identifies the image of patient 1 (CT image 6 or MRI image 7) from among the multiple stored images (CT image 6 or MRI image 7) based on the identification information 245a, thereby associating the second information 242 with the image (CT image 6 or MRI image 7).

Next, in step 412, the DICOM server 253 (server 250) transmits the identified image (CT image 6 or MRI image 7) to the X-ray imaging device 270 via the RIS server 252. That is, the DICOM server 253 (server 250) transmits the CT image 6 or MRI image 7 of patient 1 and the second information 242 to the X-ray imaging device 270 based on the request 206 and the request 207 from the X-ray imaging device 270. Then, the process ends.

(Configuration of the Angiography Device)
As shown in Figures 15 and 16, the angiography device 500 of this embodiment includes a tabletop 501 on which a patient 1 is placed, an imaging unit 502 including an X-ray source 521 and a detection unit 522, an image processing unit 503, a control unit 504, and a display unit 505.

The tabletop 501 is formed in a rectangular flat plate shape in a plan view. The tabletop 501 is placed on the tabletop so that the head-to-foot direction of the patient 1 is along the long side of the rectangle, and the left-right direction of the patient 1 is along the short side of the rectangle. In this specification, the head-to-foot direction of the patient 1 is the X direction, the left-right direction of the patient 1 is the Z direction, and the direction perpendicular to the X direction and Z direction is the Y direction.

The imaging unit 502 is configured to irradiate X-rays from the X-ray source 521 to the patient 1 and detect the X-rays that have passed through the patient 1 in the detection unit 522.

As shown in FIG. 16(b), the X-ray source 521 is attached to one end of a C-shaped holding part 523. The X-ray source 521 is capable of irradiating the patient 1 with X-rays by applying a voltage thereto by an X-ray tube driving part (not shown). The X-ray source 521 has a collimator capable of adjusting the X-ray irradiation field, which is the irradiation range of the X-rays.

The detector 522 is attached to the other end of the holder 523. That is, the detector 522 is disposed on the opposite side of the top plate 501 from the X-ray source 521. The detector 522 is disposed opposite the X-ray source 521, and is therefore configured to be able to detect X-rays that have passed through the patient 1. The detector 522 includes, for example, an FPD (flat panel detector).

As shown in FIG. 15, the image processing unit 503 is a computer configured to include a processor such as a GPU (Graphics Processing Unit) or an FPGA (Field-Programmable Gate Array) configured for image processing. The image processing unit functions as an image processing device by executing an image processing program.

The image processing unit 503 is configured to generate a fluoroscopic image 520 (see FIG. 16) of the patient 1 based on the detection signal output from the detection unit 522.

The control unit 504 is a computer that includes a CPU (Central Processing Unit), a ROM (Read Only Memory), and a RAM (Random Access Memory).

The control unit 504 is configured to acquire a CT image 6 or an MRI image 7 from the server 506. Here, the "CT image" and the "MRI image" are examples of the "vascular image data" described in the claims. The server 506 has a similar configuration to the server 250 (see Figures 10 and 11), and therefore a detailed description thereof will be omitted.

As shown in FIG. 15, the control unit 504 is configured to acquire a CT image 6 or an MRI image 7 of the patient 1 undergoing fluoroscopic imaging from the server 506 based on the patient information 545 of the patient 1 undergoing fluoroscopic imaging.

The control unit 504 is configured to select, from among the CT images 6 or MRI images 7 of the patient 1 undergoing fluoroscopic imaging, a CT image 6 or an MRI image 7 having the same spatial coordinates as the fluoroscopic image 520 generated by the image processing unit 503. FIG. 16 is a schematic diagram showing the process of generating a superimposed image 530 of the head 550 of the patient 1. The control unit 504 is configured to control the display unit 505 to superimpose (layer) the fluoroscopic image 520 on the acquired CT image 6 or MRI image 7 and display it.

As shown in FIG. 17, the control unit 504 is configured to control the display unit 505 to display the treatment position 511 together with the superimposed image 530 when the treatment position (thrombus site) 511 is associated with the CT image 6 or MRI image 7. In FIG. 17, a mark 531 is attached to the treatment position 511. The mark 531 may be a shape that surrounds the treatment position 511, or an arrow may be displayed.

The control unit 504 is configured to control the acquisition of genetic information 540 that matches patient information 545 of the patient 1 undergoing fluoroscopic imaging from the server 506. The genetic information 540 includes at least one of the first information 541 and the second information 542. The first information 541 is the same as the first information 41 (see FIG. 4). That is, the first information 541 includes patient information 545 and information on the presence/absence of genetic polymorphism. The second information 542 is the same as the second information 42 (see FIG. 4). That is, the second information 542 includes at least one of information 42a on the type of cerebral infarction, information 42b on the cerebral blood vessels of the patient 1, and information 42c indicating a treatment device that is recommended or not recommended for use in cerebral infarction catheter treatment of the patient 1.

The control unit 504 is configured to control the display unit 505 to further display genetic information 540 on the image in which the fluoroscopic image 520 and the CT image 6 or MRI image 7 are superimposed. The control unit 504 is configured to control the display unit 505 to display the genetic information 540 at a position that does not overlap the treatment position 511. As shown in FIG. 17, when a mark 531 indicating the treatment position 511 is displayed, the position that does not overlap the mark 531 is a position that does not overlap the mark 531.

The display unit 505 is a monitor attached to the angiography device 500. As shown in FIG. 17, the catheter 512 is clearly captured in the fluoroscopic image 520, but the blood vessel 513 is not. Therefore, by superimposing the CT image 6 or the MRI image 7, a superimposed image 530 in which the catheter 512 and the blood vessel 513 are superimposed is generated. As shown in FIG. 17, in the superimposed image 530, the pixel value of the blood vessel 513 is inverted to make the catheter 512 clear. In FIG. 17, the pixel value of the blood vessel 513 is white to indicate that it has been inverted. The pixel value of the catheter 512 may also be inverted. In addition, the superimposed image displays a mark 531 indicating the treatment position 511 and genetic information 540. In FIG. 17, the genetic information 540 is expressed by characters. The superimposed image 530, the treatment position 511, and the genetic information 540 are displayed on the display unit 505 attached to the angiography device 500, so that the doctor or the like can check them during treatment. The displayed genetic information 540 is at least one of the first information 541 and the second information 542.

(Procedure for diagnosis by doctors, etc.)
When a patient 1 suffering from cerebral infarction is transported to a hospital, a doctor or the like takes a CT image 6 or an MRI image 7 .

In CT imaging, the patient 1 is imaged from multiple directions while rotating and moving the imaging unit. As shown in FIG. 18(a), multiple two-dimensional image data are generated in CT imaging. FIG. 18(a) shows an image captured while moving in the head-to-foot direction (X direction). Then, as shown in FIG. 18(b), three-dimensional image data can be generated by reconstructing multiple two-dimensional CT images 6 captured in succession. The desired CT image 6 can be obtained by cutting the three-dimensional data in any direction. For example, if blood vessels 513 extend along the head-to-foot direction, the reconstructed three-dimensional image data can be cut in a direction parallel to the head-to-foot direction (X direction) as shown in FIG. 18(c).

In addition, three-dimensional image data can be generated by reconstructing the MRI image 7. An image of the blood vessel 513 can be generated by cutting the generated three-dimensional image data in the direction in which the blood vessel extends.

The doctor or the like confirms the treatment position 511, which is the treatment position, from the CT image 6 or MRI image 7 taken in the image reading room 901. The doctor or the like selects the treatment position 511 in the CT image 6 or MRI image 7, whereby the treatment position 511 is marked and the treatment position 511 is associated with the CT image 6 or MRI image 7.

In the case of CT image 6, doctors and the like can identify the treatment position 511 based on the CT value, which is the X-ray absorption value. Here, in the case of cerebral infarction, a blood vessel 513 at the treatment position 511 has a thrombus. A thrombus absorbs X-rays more than a blood vessel to which a contrast agent has been administered, so it has a higher CT value and appears darker than a blood vessel without a thrombus. Doctors and the like can identify the treatment position 511 based on the difference in CT value.

In the case of MRI image 7, a doctor or the like can identify the treatment position 511 based on the detection signal. The detection signal is strong where blood flow is fast and weak where blood flow is slow, so blood vessels with slow blood flow (where cerebral infarction is occurring) are displayed darker than other blood vessels. This allows a doctor or the like to identify the treatment position 511.

After taking CT images 6 and MRI images 7 of patient 1, the doctor starts treatment to remove the thrombus. As shown in FIG. 17, when the doctor starts fluoroscopy for treatment, a superimposed image 530 in which the fluoroscopy image 520 and the CT image 6 or MRI image 7 are superimposed, and genetic information 540 are displayed on the display unit 505. As shown in FIG. 17, a mark 531 is placed on the treatment position 511 of the CT image 6 or MRI image 7, so that the treatment position 511 can be confirmed even if the doctor performing the treatment is different from the doctor performing the diagnosis in the reading room 901. Since the superimposed image 530 and genetic information 540 are displayed on the display unit 505, the doctor can perform the surgery smoothly.

Next, the fluoroscopic imaging operation of the angiography device 500 will be described with reference to FIG.

In step 601, the angiography device 500 starts vascular fluoroscopy by accepting input from the user. When vascular fluoroscopy starts, the angiography device 500 irradiates X-rays from the X-ray source 521 to the patient 1. The detection unit 522 detects the X-rays that have passed through the patient 1 and outputs a detection signal.

In step 602, the image processing unit 503 generates a perspective image 520 based on the detection signal.

In step 603, the control unit 504 controls the acquisition from the server 506 of a CT image 6 or an MRI image 7 having the same spatial position coordinates as the fluoroscopic image 520 generated in step 602.

In step 604, the control unit 504 controls the display unit 505 to display the fluoroscopic image 520 superimposed on the acquired CT image 6 or MRI image 7.

In step 605, the control unit 504 controls the acquisition of genetic information 540 that matches the patient information 545 from the server.

In step 606, the control unit 504 controls the display unit 505 to display the acquired genetic information 540 and a superimposed image 530 in which the CT image 6 or MRI image 7 and the fluoroscopic image 520 are superimposed.

(Effects of this embodiment)
In this embodiment, the following effects can be obtained.

In this embodiment, the angiography device 500 includes an imaging unit 502 including an X-ray source 521 that irradiates radiation to the patient 1, a detection unit 522 that detects the X-rays irradiated from the X-ray source 521 and transmitted through the patient 1, and acquires a detection signal, an image processing unit 503 that generates a fluoroscopic image 520 of the patient 1 based on the detection signal, a control unit 504 that acquires genetic information 540 of the patient 1 including first information 541 on whether the patient 1 has a susceptibility gene for cerebral infarction and second information 542 related to the susceptibility gene, and a display unit 505 that displays the fluoroscopic image 520 and at least one of the first information 541 and the second information 542 of the genetic information 540 during fluoroscopic imaging. As a result, the genetic information 540 related to cerebral infarction is displayed during fluoroscopic imaging, allowing a doctor to acquire information regarding cerebral infarction.

In this embodiment, the display unit 505 is configured to display the genetic information 540 at a position that does not overlap the treatment position 511 on the fluoroscopic image 520. As a result, the genetic information 540 and the treatment position 511 are displayed so as not to overlap, allowing the doctor to perform fluoroscopic imaging and treatment while clearly checking both the treatment position 511 and the genetic information 540.

In this embodiment, the display unit 505 is configured to display at least the second information 542 of the genetic information 540 including the first information 541 and the second information 542, and the second information 542 includes at least one of information on the type of cerebral infarction, information on the cerebral blood vessels of the patient 1, and information indicating a treatment device that is recommended or not recommended for use in cerebral infarction catheter treatment of the patient 1. As a result, by displaying the second information 542, the doctor can easily create a treatment plan and perform rapid treatment.

In this embodiment, the control unit 504 is further configured to acquire information regarding the cerebral infarction treatment position 511, and the display unit 505 is further configured to display information regarding the cerebral infarction treatment position 511. As a result, the information regarding the cerebral infarction treatment position 511 is displayed, allowing the doctor to easily confirm the treatment position 511.

In this embodiment, the susceptibility gene for cerebral infarction includes the RNF213p.R4810K gene polymorphism. This makes it possible to determine whether patient 1 is prone to developing a particular type of cerebral infarction.

In this embodiment, the control unit 504 is further configured to control the acquisition of a CT image 6 or an MRI image 7 of the patient 1 that has been taken in advance, and the display unit 505 is configured to display an image in which the fluoroscopic image 520 and the CT image 6 or MRI image 7 are superimposed, and genetic information 540, during fluoroscopic photography. This allows the doctor to perform fluoroscopic photography and treatment while more clearly checking the treatment position 511.

In this embodiment, the control unit 504 is further configured to control the acquisition of information regarding the cerebral infarction treatment position 511 associated with the CT image 6 or MRI image 7, and the display unit 505 is further configured to display information regarding the cerebral infarction treatment position 511. As a result, even if the doctor who performs the diagnosis using the CT image 6 or MRI image 7 is different from the doctor who performs the treatment, by associating the treatment position 511 with the CT image 6 or MRI image 7, the doctor who performs the treatment can easily confirm the treatment position 511.

In this embodiment, the control unit 504 is configured to control the acquisition of the CT image 6 or MRI image 7 based on the patient information 545 of the patient 1 from the server 506 in which the CT image 6 or MRI image 7 is stored, and is also configured to control the acquisition of the genetic information 540 based on the patient information 545 of the patient 1 from the server 506 in which the genetic information 540 is stored. As a result, even if the room in which the CT image 6 or MRI image 7 is acquired is different from the room in which the vascular fluoroscopy is performed, the CT image 6 or MRI image 7 required during treatment can be acquired because the CT image 6 or MRI image 7 is stored in the server 506. In addition, since the control unit 504 is configured to acquire the CT image 6 or MRI image 7 based on the patient information 545, even if many CT images 6 or MRI images 7 are stored in the server 506, the CT image 6 or MRI image 7 of the patient 1 to be treated can be easily acquired.

In this embodiment, the vascular image data is an image obtained by reconstructing a CT image or an MRI image. As a result, even in cases where imaging using a contrast agent is not possible, such as in the case of cerebral infarction, three-dimensional vascular image data can be obtained by reconstructing a CT image 6 or an MRI image 7. Therefore, by superimposing the fluoroscopic image 520, it is possible to perform treatment while checking the shape of the blood vessel 513.

In this embodiment, the angiography method includes the steps of irradiating X-rays to a patient 1 and generating a fluoroscopic image 520, acquiring genetic information 540 of the patient 1, the genetic information 540 including at least one of first information 541 indicating whether the patient 1 has a susceptibility gene for cerebral infarction and second information 542 related to the susceptibility gene, and displaying the fluoroscopic image 520 and the genetic information 540. As a result, the genetic information 540 related to cerebral infarction is displayed during fluoroscopic imaging, allowing a doctor to acquire information related to cerebral infarction.

[Modification]
It should be noted that the embodiments disclosed herein are illustrative and not restrictive in all respects. The scope of the present invention is indicated by the claims, not by the description of the embodiments above, and further includes all modifications (variations) within the meaning and scope of the claims.

For example, in the above embodiment, the second information 542 includes at least one of information on the type of cerebral infarction, information on cerebral blood vessels, and device information, but the present invention is not limited to this. The second information 542 may include information other than the above information as long as it is information derived from the first information 541.

In addition, in the above embodiment, an example was shown in which the vascular image data was an MRI image 7 or a CT image 6, but the present invention is not limited to this. For example, if a contrast agent image of patient 1 is stored, the vascular image data may be a contrast agent image.

For example, in the above embodiment, an example was shown in which genetic information 540 is displayed within superimposed image 530, but the present invention is not limited to this. In the present invention, genetic information 540 may be displayed outside superimposed image 530.

For example, in the above embodiment, an example was shown in which an image in which a blood vessel image and a fluoroscopic image are superimposed, and genetic information are displayed, but the present invention is not limited to this. In the present invention, a fluoroscopic image and genetic information may also be displayed.

[Aspects]
It will be appreciated by those skilled in the art that the exemplary embodiments described above are examples of the following aspects.

(Item 1)
An angiography apparatus for use in a cerebral infarction treatment support system,
an imaging unit including an X-ray source that irradiates a patient with radiation, and a detection unit that detects the X-rays irradiated from the X-ray source and transmitted through the patient, and acquires a detection signal;
an image processor for generating a fluoroscopic image of the patient based on the detection signal;
A control unit that acquires genetic information of the patient, the genetic information including at least one of first information on whether the patient 1 has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene;
a display unit on which the fluoroscopic image and the genetic information are displayed during fluoroscopic photography.

(Item 2)
2. The angiography apparatus according to claim 1, wherein the display unit is configured to display the genetic information at a position that does not overlap with a treatment position on the fluoroscopic image.

(Item 3)
The genetic information includes at least the second information,
3. The angiography apparatus according to item 1 or 2, wherein the second information includes at least any one of information regarding a type of cerebral infarction, information regarding cerebral blood vessels of the patient, and information indicating a treatment device whose use is recommended or not recommended in cerebral infarction catheter treatment of the patient.

(Item 4)
The control unit is further configured to perform control to acquire information regarding a treatment position of the cerebral infarction,
4. The angiography apparatus according to any one of items 1 to 3, wherein the display unit is further configured to display information regarding a treatment position of the cerebral infarction.

(Item 5)
5. The angiography apparatus according to any one of items 1 to 4, wherein the susceptibility gene for cerebral infarction includes a gene polymorphism of RNF213 p.R4810K.

(Item 6)
The control unit is further configured to perform control to acquire blood vessel image data of the patient that has been previously captured,
6. The angiography apparatus according to any one of claims 1 to 5, wherein the display unit is configured to display an image in which the fluoroscopic image and the vascular image data are superimposed and the genetic information during fluoroscopic imaging.

(Item 7)
The control unit is further configured to perform control to acquire information regarding a treatment position of the cerebral infarction associated with the vascular image data,
7. The angiography apparatus according to item 6, wherein the display unit is further configured to display information regarding a treatment position of the cerebral infarction.

(Item 8)
8. The angiography apparatus according to claim 6, wherein the control unit is configured to control acquisition of the vascular image data from a server in which the vascular image data is stored based on patient information of the patient, and is configured to control acquisition of the genetic information from a server in which the genetic information is stored based on the patient information of the patient.

(Item 9)
9. The angiography apparatus according to any one of items 6 to 8, wherein the angiography image data is an image reconstructed from a CT image or an MRI image.

(Item 10)
An angiography method for use in a cerebral infarction treatment support system, comprising:
irradiating the patient with x-rays to generate a fluoroscopic image;
Obtaining genetic information of the patient 1, the genetic information including at least one of first information on whether the patient has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene;
and displaying the fluoroscopic image and the genetic information.

6 CT image 7 MRI image 500 Angiography device 501 Top plate 502 Imaging section 503 Image processing section 504 Control section 505 Display section 506 Server 511 Treatment position 520 Fluoroscopic image 521 X-ray source 522 Detection section 540 Genetic information 541 First information 542 Second information

Claims (8)

An angiography apparatus for use in a cerebral infarction treatment support system,
an imaging unit including an X-ray source that irradiates a patient with radiation, and a detection unit that detects the X-rays irradiated from the X-ray source and transmitted through the patient, and acquires a detection signal;
an image processor for generating a fluoroscopic image of the patient based on the detection signal;
A control unit that acquires genetic information of the patient, the genetic information including at least one of first information on whether the patient has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene;
a display unit on which the fluoroscopic image and the genetic information are displayed during fluoroscopic photography,
The genetic information includes at least the second information,
The second information includes at least one of information regarding the type of cerebral infarction, information regarding the patient's cerebral blood vessels, and information indicating a treatment device that is recommended or not recommended for use in cerebral infarction catheter treatment for the patient , an angiography apparatus. An angiography apparatus for use in a cerebral infarction treatment support system,
an imaging unit including an X-ray source that irradiates a patient with radiation, and a detection unit that detects the X-rays irradiated from the X-ray source and transmitted through the patient, and acquires a detection signal;
an image processor for generating a fluoroscopic image of the patient based on the detection signal;
A control unit that acquires genetic information of the patient, the genetic information including at least one of first information on whether the patient has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene;
a display unit on which the fluoroscopic image and the genetic information are displayed during fluoroscopic photography,
The control unit is further configured to perform control to acquire information regarding a treatment position of the cerebral infarction,
The angiography apparatus, wherein the display unit is further configured to display information regarding a treatment position for the cerebral infarction. An angiography apparatus for use in a cerebral infarction treatment support system,
an imaging unit including an X-ray source that irradiates a patient with radiation, and a detection unit that detects the X-rays irradiated from the X-ray source and transmitted through the patient, and acquires a detection signal;
an image processor for generating a fluoroscopic image of the patient based on the detection signal;
A control unit that acquires genetic information of the patient, the genetic information including at least one of first information on whether the patient has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene;
a display unit on which the fluoroscopic image and the genetic information are displayed during fluoroscopic photography,
The susceptibility gene for cerebral infarction includes a genetic polymorphism of RNF213p.R4810K. An angiography apparatus for use in a cerebral infarction treatment support system,
an imaging unit including an X-ray source that irradiates a patient with radiation, and a detection unit that detects the X-rays irradiated from the X-ray source and transmitted through the patient, and acquires a detection signal;
an image processor for generating a fluoroscopic image of the patient based on the detection signal;
A control unit that acquires genetic information of the patient, the genetic information including at least one of first information on whether the patient has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene;
a display unit on which the fluoroscopic image and the genetic information are displayed during fluoroscopic photography,
The control unit is further configured to perform control to acquire blood vessel image data of the patient that has been previously captured,
The display unit is configured to display, during fluoroscopic imaging, an image in which the fluoroscopic image and the vascular image data are superimposed, and the genetic information. The control unit is further configured to control acquisition of vascular image data of the patient captured in advance, and to control acquisition of information regarding a treatment position of the cerebral infarction associated with the vascular image data,
2. The angiography apparatus according to claim 1, wherein the display unit is configured to display , during fluoroscopy, an image in which the fluoroscopic image and the vascular image data are superimposed, the genetic information, and information regarding a treatment position of the cerebral infarction . the control unit is further configured to control acquisition of vascular image data of the patient captured in advance, to control acquisition of the vascular image data from a server storing the vascular image data based on patient information of the patient, and to control acquisition of genetic information from the server storing the genetic information based on the patient information of the patient ,
2. The angiography apparatus according to claim 1 , wherein the display unit is configured to display, during fluoroscopic imaging, an image in which the fluoroscopic image and the vascular image data are superimposed, and the genetic information . The control unit is further configured to perform control to acquire blood vessel image data of the patient that has been previously captured,
the display unit is configured to display an image in which the fluoroscopic image and the vascular image data are superimposed and the genetic information during fluoroscopic imaging;
2. The angiography apparatus according to claim 1 , wherein the blood vessel image data is an image reconstructed from a CT image or an MRI image. An angiography method for use in a cerebral infarction treatment support system, comprising:
an x-ray source irradiating a patient with x-rays and an image processor generating a fluoroscopic image;
A step of acquiring genetic information of the patient, the genetic information including at least one of first information on whether the patient has a susceptibility gene for cerebral infarction and second information related to the susceptibility gene, by a control unit;
a display unit displays the fluoroscopic image and the genetic information during fluoroscopic photography ;
The genetic information includes at least the second information,
An angiography method, wherein the second information includes at least one of information regarding the type of cerebral infarction, information regarding the patient's cerebral blood vessels, and information indicating a treatment device that is recommended or not recommended for use in catheter treatment of cerebral infarction of the patient .

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