JP7514009B2 - Tabletop mixer settler and extraction method using same - Google Patents

Description

The present invention relates to a tabletop mixer settler and an extraction method using it.

Figure 5 of Patent Document 1 describes how an emulsion is produced by mixing a continuous phase and a dispersed phase, which are immiscible liquids, in a microreactor. The emulsion is stored in a container housed in a water tank. The emulsion is separated into the continuous phase and the dispersed phase by irradiating the emulsion with ultrasonic waves. A solute is dissolved in either the continuous phase or the dispersed phase. During the emulsification and separation process, the solute is said to move from one of the continuous phase and the dispersed phase to the other by liquid-liquid extraction.

JP 2010-269256 A

As shown in Patent Document 1, mixer settlers are well known. The mixer settler of Patent Document 1 uses a microreactor as a mixer, and is therefore easier to handle than mixer settlers that use a stirring device consisting of a large stirrer and a large tank, and a separation tank consisting of a large tank. However, in conventional mixer settlers such as those in Patent Document 1, the mixer and the separation tank are configured separately. To use the mixer settler, it is necessary to carry the mixer and the separation tank on a table and connect them with a transport path, which is a time-consuming preparation. In addition, after using the mixer settler, it is time-consuming to separate and clean the mixer and the separation tank. When moving the mixer settler, it is necessary to transport the mixer and the separation tank in a separated state, and then to connect the mixer and the separation tank again. Thus, the conventional mixer settler has the problem that it is time-consuming to use the mixer settler.

The present invention aims to provide a tabletop mixer-settler that integrates the mixing section and the separation tank so that the mixing section and the separation tank can be handled as a single device, and an extraction method that uses the same.

The above-mentioned problem is solved by a tabletop mixer settler having a mixing section for mixing a plurality of liquids and a separation tank for storing and separating the plurality of liquids mixed in the mixing section, the mixing section being a flow path consisting of a groove or a slit-shaped through hole provided in a substrate having a predetermined thickness, the separation tank being a recess or a through hole provided in the substrate, the mixing section and the separation tank being connected to each other, and the mixing section and the separation tank being integrated into one device by fixing the substrate and the lid in a liquid-tight state with the substrate covered with a lid. In this mixer settler, the mixing section and the separation tank are provided in the substrate. By fixing the lid to the substrate, the mixing section and the separation tank are integrated into one device in a liquid-tight state. Since the mixing section and the separation tank are integrated and can be handled as one device, when the mixer settler is installed on a substrate, for example, a substrate does not need to be installed on the substrate separately, and it is sufficient to perform the operation of installing the mixer settler on the substrate once. The mixing section and separation tank are integrated in the base material, so by washing the base material after use, the mixing section and separation tank can be washed at the same time.

In the above mixer settler, the lid is preferably made of a see-through material. This makes it possible to observe how the liquids are mixed in the mixing section, or how the mixed liquids are separated in the separation tank. It is also possible to irradiate light such as ultraviolet light from outside the mixer settler through the lid to cause a chemical reaction that requires light.

In the above mixer settler, a protective member is fixed to the lid, and the protective member is preferably configured to have a window with a through hole at the position of the mixing section or separation tank. The protective member can prevent damage to the lid, which is configured to be see-through. Since the protective member has a window, it is possible to observe the mixing section or separation tank through the window, and to irradiate the mixing section or separation tank with light through the window.

The above mixer settler may further include a second lid body separate from the lid body, and the lid body may be fixed to one side of the base material, and the second lid body may be fixed to the other side of the base material that is disposed opposite the one side. This configuration may be preferably adopted when the mixing section or separation tank is configured as a through hole. When the mixing section or separation tank is configured as a through hole, there is an advantage that there is no need to pay attention to the machining accuracy of the depth of the recessed hole, and machining of the base material becomes relatively easy.

In the above mixer settler, a second protective member that is separate from the protective member and prevents damage to the second lid can be fixed to the second lid. This makes it possible to prevent damage to the second lid.

In the above mixer settler, the base material and the lid can be fixed with multiple screws. With this configuration, the base material and the lid can be firmly fastened together. In addition, the base material and the lid can be easily disassembled by loosening the screws.

In the above mixer settler, the mixing section and the separation tank are connected by a tube, and the tube is preferably configured to be detachable from the tabletop mixer settler. With this configuration, for example, it is possible to remove one short tube and replace it with another long tube, thereby adjusting the length of time that multiple liquids are mixed downstream of the mixing section, i.e., the time that one liquid is in contact with the other liquids.

The above-mentioned mixer settler may be used alone or in combination. For example, this is an extraction method in which a first liquid and a second liquid, which are incompatible with each other and have different specific gravities, are mixed in a mixing section, an extraction substance contained in one of the first and second liquids is transferred to the other liquid, and the mixed liquid is gravity separated in a separation tank, one liquid is discharged, and the other liquid is recovered.

In addition, the extraction method includes the steps of, for example, mixing a first liquid and a second liquid that are incompatible with each other and have different specific gravities in a mixing section of a first mixer settler, transferring an extract substance contained in one of the first and second liquids to the other liquid, separating the mixed liquid by specific gravity in a separation tank of the first mixer settler, discharging one of the liquids, and recovering the other liquid, mixing the recovered other liquid with a third liquid containing the extract substance in the mixing section of a second mixer settler, transferring an extract substance contained in the third liquid to the other liquid, separating the mixed liquid by specific gravity in the separation tank of the second mixer settler, discharging the third liquid, and recovering the other liquid.

According to the present invention, it is possible to provide a tabletop mixer-settler in which the mixing section and the separation tank are integrated and can be handled as a single device, as well as an extraction method using the same.

FIG. 1 is an exploded perspective view of a first embodiment of a tabletop mixer-settler. FIG. 2 is a perspective view of the tabletop mixer-settler of FIG. 1. FIG. 2 is a front view of the tabletop mixer-settler of FIG. 1. FIG. 2 is a plan view of the tabletop mixer-settler of FIG. 1. FIG. 2 is a front view of a first lid body in the tabletop mixer settler of FIG. 1. FIG. 2 is a front view of a first protective member in the tabletop mixer-settler of FIG. 1 . FIG. 2 is a front view of a substrate in the tabletop mixer-settler of FIG. 1 . FIG. 11 is an exploded perspective view of a second embodiment of the tabletop mixer-settler. FIG. 9 is a perspective view of the tabletop mixer-settler of FIG. 8 . FIG. 11 is an exploded perspective view of a third embodiment of the tabletop mixer-settler. FIG. 11 is a perspective view of the tabletop mixer-settler of FIG. FIG. 2 is a perspective view showing an example of a method of using the tabletop mixer-settler of FIG. 1. FIG. 2 is a front view showing another example of how to use the tabletop mixer-settler of FIG. 1. 2 is a photograph showing the front of the tabletop mixer settler of FIG. 1. 2 is a photograph showing the rear of the tabletop mixer settler of FIG. 1. 2 is a photograph showing the right side of the tabletop mixer settler of FIG. 1. 2 is a photograph showing the left side of the tabletop mixer settler of FIG. 1. 2 is a photograph showing a plan view of the tabletop mixer settler of FIG. 1. 2 is a photograph showing the bottom surface of the tabletop mixer settler of FIG. 1. 2 is a photograph showing the shape of the tabletop mixer settler of FIG. 1 as viewed obliquely from above. 2 is a photograph for explaining the use state of the tabletop mixer settler of FIG. 1. 2 is a photograph for explaining the use state of the tabletop mixer settler of FIG. 1.

The following describes an example of a tabletop mixer settler (hereinafter simply referred to as a mixer settler) of the present invention and an example of how to use it. The mixer settler and its use example shown below are merely illustrative, and the technical scope of the present invention is not limited to these.

Figures 1 to 7 show a first embodiment of the mixer settler. Figures 8 and 9 show a second embodiment of the mixer settler. Figures 10 and 11 show a third embodiment of the mixer settler. Figures 12 and 13 show an example of how the mixer settler is used. Figures 14 and onwards show photographs of the mixer settler in Figure 1.

[First embodiment]
As shown in Fig. 1, the mixer settler 1a of this embodiment has a mixing section 11a for mixing a plurality of liquids and a separation tank 12a for storing and separating the plurality of liquids mixed in the mixing section 11a. The mixing section 11a and the separation tank 12a are provided on a base material 13a having a predetermined thickness.

The shape of the flow path in the mixing section is a flow path consisting of a groove or a slit-shaped through hole provided in the base material, and may be any shape that can mix multiple liquids. As shown in Figures 1 and 3, the mixer settler 1a of this embodiment has two liquid inlets 111a, two inlet paths 112a connected to the inlet 111a, a junction where the two inlet paths 112a join, one transport path 113a connected to the junction, and an outlet 114a connected to the transport path 113a. The mixing section 11a is Y-shaped. The inlet path 112a and the transport path 113a are configured as bottomed grooves provided in the base material 13a. In Figure 3, the components hidden by the first protective member 15a, etc. are shown by dashed lines.

The shape of the separation tank is a recess or through-hole provided in the base material, and it is sufficient if it can store the mixed liquids and separate them into phases based on their specific gravity. In the mixer settler 1a of this embodiment, the separation tank 12a is composed of a triangular through-hole that penetrates the base material 13a.

The base material has a shape that allows the formation of the grooves or slit-shaped through holes that form the mixing section and the recesses or through holes that form the separation tank, and can be shaped to fix the lid. In the mixer settler 1a of this embodiment, the base material 13a is composed of a plate that is square when viewed from the front.

As shown in Figures 1 and 2, in the mixer settler 1a of this embodiment, one side of the base material 13a is covered with a first lid 14a, and the base material 13a and the first lid 14a are fixed in a liquid-tight state, and the other side of the base material is covered with a second lid 16a, and the base material 13a and the second lid 16a are fixed in a liquid-tight state. This makes it possible to integrate the mixing section 11a and the separation tank 12a and handle them as a single device, and also keeps the mixing section 11a and the separation tank 12a liquid-tight.

In the mixer settler 1a of this embodiment, the first cover 14a and the second cover 16a are made of quartz glass, which is a see-through material. A first protective member 15a having a window 157 with a through hole at the position of the mixing section 11a or the separation tank 12a is fixed to the first cover 14a. A second protective member 17a without a window is fixed to the second cover 16a. The state inside the mixing section 11a or the separation tank 12a can be observed through the first cover 14a and the window 157 of the first protective member 15a. It is also possible to irradiate the mixing section 11a or the separation tank 12a with light such as ultraviolet light through the first cover 14a and the window 157 of the first protective member 15a.

In the mixer settler 1a of this embodiment, the window 157 of the mixing section 11a is rectangular with arc-shaped corners, and the window 157 of the separation tank 12a is triangular with arc-shaped corners. Each window 157 is configured to be smaller in size when viewed from the front than the mixing section 11a or separation tank 12a. As a result, the first protective member 15a is provided with through holes from the first hole 151 to the sixth hole 156, as described below.

In the mixer settler 1a of this embodiment, the base material 13a, the first lid body 14a, the first protective member 15a, the second lid body 16a, and the second protective member 17a are fixed to each other by inserting a plurality of screws 181 into through holes 182 and screw holes 183 provided in each member and fastening the plurality of screws 181. Therefore, by loosening the screws 181, each member can be disassembled and cleaned, or damaged members can be replaced with new ones.

The first cover 14a and the first protective member 15a are provided with a plurality of through holes that communicate with the inlet 111a, the outlet 114a, or the separation tank 12a provided in the base material 13a. As shown in FIG. 5, the first cover 14a of the mixer settler 1a of this embodiment is provided with a first hole 141, a second hole 142, a third hole 143, a fourth hole 144, a fifth hole 145, and a sixth hole 146. Similarly, the first protective member 15a is provided with a first hole 151, a second hole 152, a third hole 153, a fourth hole 154, a fifth hole 155, and a sixth hole 156 as shown in FIG. 6.

The first holes 141 and 151 communicate with the inlet 111a of the mixing section 11a shown in FIG. 7. Similarly, the second holes 142 and 152 communicate with the inlet 111a of the mixing section 11a. A liquid to cause a reaction is supplied to the first holes 141 and 151 and the second holes 142 and 152 by a syringe pump or the like. The mixture of multiple liquids that has passed through the inlet 111a of the mixing section 11a, the inlet path 112a, the junction, and the transport path 113a flows to the outlet 114a. The outlet 114a communicates with the third holes 143 and 153.

As shown in FIG. 12, a tube 16 that connects the mixing section 11a and the separation tank 12a is connected to the third holes 143 and 153. The tube 16 is exposed to the outside of the first protective member 15a, and one end of the tube 16 is connected to the third holes 143 and 153, and the other end of the tube 16 is connected to the fourth holes 144 and 154.

The fourth holes 144 and 154 communicate with the triangular separation tank 12a as shown in Figures 3 and 7. The mixed liquid mixed in the mixing section 11a is supplied to the separation tank 12a through the tube 16 and stored. The mixed liquid is stored in the storage tank and separated. The upper part of the separation tank 12a communicates with the fifth holes 145 and 155. The liquid located at the upper part of the liquid separated in the separation tank is discharged to the outside of the device through the fifth holes 145 and 155. The lower part of the separation tank 12a communicates with the sixth holes 146 and 156. The liquid located at the lower part of the liquid separated in the separation tank 12a is discharged to the outside of the device through the sixth holes 146 and 156.

Tube 16 has male threads at one end and the other end, and is configured to be detachable by screwing into the female threads provided in third holes 143, 153 and fourth holes 144, 154. By preparing multiple tubes of different lengths and shapes and replacing the tubes, it is possible to freely adjust the mixing time and strength of mixing within the tube. The shape of the tube can be straight, spiral, etc.

In the mixer settler 1a of this embodiment, the tube 16 is exposed to the outside of the device. To prevent the tube 16 from interfering with other objects and becoming a hindrance, or from being damaged, the tube 16 is made of a flexible material. Specifically, the material of the tube 16 is polytetrafluoroethylene.

As shown in FIG. 2, the mixer settler 1a of this embodiment has the mixing section 11a and the separation tank 12a integrated by the base material 13a, the first lid 14a, and the second lid 16a. Therefore, when using the mixer settler 1a, there is no need to transport the mixing section 11a and the separation tank 12a separately, and they can be handled as one device. Since the mixing section 11a and the separation tank 12a are provided on the base material 13a, there is no need to clean the mixing section 11a and the separation tank 12a separately. For example, the mixing section and the separation tank can be cleaned simultaneously by immersing the base material 13a in a liquid containing water and a surfactant and irradiating it with ultrasonic waves.

[Second embodiment]
The mixer settler 1a of the first embodiment includes a second cover 16a and a second protective member 17a. As shown in Figures 8 and 9, the mixer settler 1b of the second embodiment does not include the second cover 16a and the second protective member 17a, and differs in that the separation tank 12b provided in the base material 13b is configured as a bottomed recessed hole. In Figures 8 and 9, the same symbols as those used in Figures 1 to 7 are used for components common to the mixer settler 1a of the first embodiment.

In the mixer settler 1b of this embodiment, the mixing tank 12b does not penetrate the base material 13b. Therefore, the other side of the base material 13b is liquid-tight without being covered with the second lid material, and as described above, there is no need to provide the second lid body 16a and the second protective member 17a. Since the second lid body 16a and the second protective member 17a can be omitted, the device can be made smaller and lighter accordingly. In the mixer settler 1b of this embodiment, the base material 13b, the first lid body 14a, and the first protective member 15a are integrated together.

[Third embodiment]
As shown in Figures 10 and 11, the mixer settler 1c of the third embodiment is different from the mixer settler 1a of the first embodiment in the configuration of the base material 13c. In Figures 10 and 11, the same reference numerals as those used in Figures 1 to 7 are used for the configurations common to the mixer settler 1a of the first embodiment.

In the mixer settler 1c of this embodiment, the base material 13c is composed of a block-shaped member. The base material 13c has a square shape when viewed from the front. The separation tank 12c is composed of a triangular through hole that penetrates the block-shaped base material 13c from the front to the back. The mixing section 11c is composed of a bottomed groove like the mixer settler 1a of the first embodiment, but the groove is deeper. The liquid flows in the same way as the mixing section 11a of the mixer settler 1a of the first embodiment. The mixer settler 1c of the third embodiment has the above-mentioned configuration, and is configured to process a larger amount of liquid per unit time than the mixer settler 1a of the first embodiment.

Next, we will explain the method of performing liquid-liquid extraction using the mixer settler 1a of the first embodiment as an example.

As shown in FIG. 12, the first liquid and the second liquid are supplied to the inlet 111a of the mixing section 11a through the first holes 141, 151 and the second holes 142, 152. A liquid delivery means such as a syringe pump can be used to supply the liquid. The first liquid and the second liquid are incompatible with each other and have different specific gravities. The second liquid has an extracting substance dissolved therein. The extracting substance has an affinity for both the second liquid and the first liquid, but has a higher affinity for the first liquid than the second liquid.

The first liquid and the second liquid pass through the inflow path 112a, join at the junction, and are mixed in the process of passing through the transport path 113a, the third holes 143, 153, and the tube 16. In the transport path 113a and the tube 16, the mixed liquid flows in a slug flow state. The mixed liquid is discharged into the separation tank 12a. In this mixing process, the extract moves from the second liquid to the first liquid due to the difference in affinity. In the separation tank 12a, the first liquid and the second liquid are separated due to the difference in specific gravity. The first liquid containing the extract is discharged outside the device through the fifth holes 145, 155 and collected. The second liquid is discharged outside the device through the sixth holes 146, 156 and discarded. In this way, the extract can be extracted from the second liquid and moved to the first liquid.

In the above example, the extract is transferred from the second liquid to the first liquid, but it is also possible to transfer the extract from the first liquid to the second liquid.

Examples of combinations of the first liquid and the second liquid include a combination of a hydrophilic liquid such as water and a hydrophobic liquid such as oil. The extraction substance may be any substance, such as an amphipathic substance that dissolves in both water and oil.

In the above method, one mixer-settler is used, but two or more mixer-settlers may be used. Figure 13 shows an example of a method for performing liquid-liquid extraction using multiple mixer-settlers.

In the method of FIG. 13, a first liquid and a second liquid, which are incompatible with each other and have different specific gravities, are mixed in the mixing section of the first mixer settler 1a. During the mixing process, the extract substance contained in the second liquid is transferred to the first liquid. The mixed liquid is gravity separated in the separation tank of the first mixer settler 1a, the second liquid is discharged, and the first liquid is recovered. Note that although the extract is transferred from the second liquid to the first liquid, the extract substance may also be transferred from the first liquid to the second liquid.

The recovered first liquid and the third liquid containing the extract are mixed in the mixing section of the second mixer settler 1a, so that the extract contained in the third liquid is transferred to the first liquid. The mixed liquid is gravity separated in the separation tank of the second mixer settler 1b, the third liquid is discharged, and the first liquid is recovered. The liquid-liquid extraction process may end here, or, as shown in FIG. 13, further liquid-liquid extraction processes may be performed using a third or subsequent mixer settler.

In the example of FIG. 13, the first liquid recovered in the second mixer settler 1a and the fourth liquid containing the extract substance are mixed in the mixing section of the mixer settler 1c of the third embodiment, and the extract substance contained in the fourth liquid is transferred to the first liquid. The mixed liquid is subjected to specific gravity separation in the separation tank of the mixer settler 1c of the third embodiment, the fourth liquid is discharged, and the first liquid is recovered. In this method, liquid-liquid extraction is performed in multiple stages, so the content of the extract substance increases stepwise. This makes it possible to further increase the concentration of the extract substance. In the above example, the first liquid and the third liquid or the fourth liquid are mutually insoluble and have different specific gravities.

The mixer settler and its method of use described above are merely examples and may be modified, for example, as shown below.

In the above example, the mixing section is a recessed groove. The mixing section may also be a slit-shaped through hole provided in the substrate. Also, in the above example, the number of injection ports and inflow paths is two, and the number of junctions is one. The configuration of the mixing section is not limited to this configuration. For example, the number of injection ports and inflow paths is not limited to two and can be any number. The number of junctions, the number of transport paths, and the number of discharge ports are also not limited to one and can be any number.

In the above example, the shape of the separation tank is triangular when viewed from the front. The shape of the separation tank is not limited to a triangle. For example, the shape of the separation tank may be a circle, including a perfect circle and an ellipse, or a polygon with more sides than a triangle.

The method of forming flow paths such as the inlet path or the transport path is not particularly limited. For example, a base material made of metal or synthetic resin material may be cut to form a bottomed groove or through hole, or a mold may be used to mold synthetic resin. The same applies to the method of forming the separation tank, the method of forming the lid part including the first lid part or the second lid part, and the method of forming the protective part including the first protective member or the second protective member.

In the above examples, the shape of the base material, lid, or protective member is rectangular when viewed from the front. The shape of the base material, lid, or protective member when viewed from the front is not limited to this, and may be, for example, a circle, including a perfect circle and an ellipse, or a polygon with a triangle or more sides. The overall shape of the base material, lid, or protective member is also not particularly limited, and may be, for example, a plate or block shape.

All of the above examples include a protective member. The protective member, including the first protective member and the second protective member, may be omitted. For example, if the lid is made of a material that is not easily damaged, the protective member may be omitted.

In the above example, quartz glass was used as the see-through material that constitutes the lid. See-through materials are not limited to this, and examples include sapphire glass, acrylic resin, polycarbonate, etc.

The thickness of the substrate is not particularly limited and can be, for example, 1 to 100 mm.

The mixer settler can be conveniently used on a tabletop such as a laboratory workbench. There are no particular limitations on the specific dimensions, but for example, the dimensions can be 50 to 300 mm wide, 50 to 300 mm high, and 10 to 300 mm deep.

In the above example, the mixing section and the separation tank are connected by a tube. The configuration for connecting the mixing section and the separation tank is not limited to this, and for example, a flow path consisting of a slit or groove that connects the mixing section and the separation tank may be provided in the base material.

The materials for the tube, base material, lid, and protective member are not particularly limited, and any material may be used depending on the application of the mixer settler. For example, polytetrafluoroethylene, tetrafluoroethylene-perfluoroalkylvinylether copolymer (PFA), or silicone may be used.

In the above example, the shape of the window is a square or a triangle. The shape of the window is not limited to this, and can be, for example, a circle or a polygon with more sides than a triangle. The window is not limited to being provided in the first protective member, and may be provided in at least one of the first protective member and the second protective member.

1a Mixer settler 11a Mixing section 12a Separation tank 13a Base material 14a First lid (lid)
16a Second cover 15a First protective member (protective member)
17a Second protective member 157 Window 181 Screw 16 Tube 1b Mixer settler 12b Separation tank 13b Base material 1c Mixer settler 11c Mixing section 12c Separation tank 13c Base material

Claims (9)

A mixing section for mixing a plurality of liquids;
and a separation tank for storing and separating the multiple liquids mixed in the mixing section.
The mixing section is a flow path formed of a groove or a slit-shaped through-hole provided in a substrate having a predetermined thickness,
The separation tank is a recess or a through hole provided in the substrate,
The mixing section and the separation tank are in communication with each other,
With the base material covered with the lid, the base material and the lid are fixed in a liquid-tight state, thereby integrating the mixing section and the separation tank into one device .
The mixing section and the separation tank are connected by a tube, the mixed liquid mixed in the mixing section is supplied to the separation tank through the tube, and the tube is exposed to the outside of the benchtop mixer-settler . The tabletop mixer settler of claim 1, in which the lid is made of a see-through material. A protective member is fixed to the lid,
3. The tabletop mixer-settler according to claim 2, wherein the protective member has a window having a through hole disposed at the position of the mixing section or the separation tank. Further comprising a second lid body separate from the lid body,
The lid is fixed to one surface of the base material,
4. The tabletop mixer-settler according to claim 1, wherein the second cover is fixed to the other surface of the base material that is disposed opposite to the one surface of the base material. The tabletop mixer settler according to claim 4, in which a second protective member separate from the protective member is fixed to the second lid to prevent damage to the lid. A tabletop mixer settler according to any one of claims 1 to 5, in which the base and the lid are fixed with a plurality of screws. The mixing section and the separation tank are connected by a tube.
7. The tabletop mixer-settler according to claim 1, wherein the tube is configured to be detachable from the tabletop mixer-settler. A method for liquid-liquid extraction using the mixer-settler according to any one of claims 1 to 7,
A first liquid and a second liquid, which are incompatible with each other and have different specific gravities, are mixed in a mixing section, so that an extracted substance contained in one of the first liquid and the second liquid is transferred to the other liquid;
An extraction method in which a mixed liquid is gravity separated in a separation tank, one liquid is discharged, and the other liquid is recovered. A method for liquid-liquid extraction by connecting a plurality of the mixer-settlers according to any one of claims 1 to 7,
A first liquid and a second liquid, which are incompatible with each other and have different specific gravities, are mixed in a mixing section of a first mixer settler, so that an extract substance contained in one of the first liquid and the second liquid is transferred to the other liquid;
The mixed liquid is subjected to gravity separation in a separation tank of the first mixer settler, and one liquid is discharged and the other liquid is recovered;
The other liquid collected is mixed with a third liquid containing the extract substance in a mixing section of a second mixer settler, thereby transferring the extract substance contained in the third liquid to the other liquid;
The extraction method includes a step of subjecting the mixed liquid to gravity separation in a separation tank of a second mixer settler, discharging a third liquid, and recovering the other liquid.

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