JP7568433B2 - Method for producing hydrolyzed eggshell membrane - Google Patents
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- JP7568433B2 JP7568433B2 JP2020118134A JP2020118134A JP7568433B2 JP 7568433 B2 JP7568433 B2 JP 7568433B2 JP 2020118134 A JP2020118134 A JP 2020118134A JP 2020118134 A JP2020118134 A JP 2020118134A JP 7568433 B2 JP7568433 B2 JP 7568433B2
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- 229940012466 egg shell membrane Drugs 0.000 title claims 11
- 238000004519 manufacturing process Methods 0.000 title claims 7
- 239000002253 acid Substances 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 102000002322 Egg Proteins Human genes 0.000 claims 4
- 108010000912 Egg Proteins Proteins 0.000 claims 4
- 210000003278 egg shell Anatomy 0.000 claims 4
- 230000007062 hydrolysis Effects 0.000 claims 4
- 238000006460 hydrolysis reaction Methods 0.000 claims 4
- 239000012528 membrane Substances 0.000 claims 4
- 239000007864 aqueous solution Substances 0.000 claims 2
- 238000011070 membrane recovery Methods 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000003729 cation exchange resin Substances 0.000 claims 1
- 238000011033 desalting Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 230000003301 hydrolyzing effect Effects 0.000 claims 1
- 239000012535 impurity Substances 0.000 claims 1
- 239000002121 nanofiber Substances 0.000 claims 1
- -1 polypropylene Polymers 0.000 claims 1
- 229920001155 polypropylene Polymers 0.000 claims 1
- 229910001415 sodium ion Inorganic materials 0.000 claims 1
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Description
本発明は、加水分解卵殻膜の製造方法に関するものである。 The present invention relates to a method for producing hydrolyzed eggshell membrane.
鶏卵などの卵の卵殻の内側にある卵殻膜を加水分解して得られる加水分解卵殻膜は育毛や健康増進などに有効であるとされている。 Hydrolyzed eggshell membrane, obtained by hydrolyzing the eggshell membrane inside the shell of eggs such as chicken eggs, is said to be effective for hair growth and health promotion.
特許文献１には、鳥類の卵殻膜を蛋白分解酵素で処理して、水溶性卵殻膜を製造する方法が記載されている。
また、特許文献２には、卵殻膜粉末をアルカリ水溶液中で加水分解して、加水分解卵殻膜を製造する方法が記載されている。
Patent Document 1 describes a method for producing water-soluble eggshell membrane by treating avian eggshell membrane with a protease.
Furthermore, Patent Document 2 describes a method for producing hydrolyzed eggshell membranes by hydrolyzing eggshell membrane powder in an alkaline aqueous solution.
特許文献１：特公平７－１１０２１０号公報
特許文献２：特許第６４１０２２９号公報
Patent Document 1: Japanese Patent Publication No. 7-110210 Patent Document 2: Patent No. 6410229
しかしながら、特許文献１に記載のものは、蛋白分解酵素が非常に高価で製造コストが高くなるという問題がある。
また、特許文献２に記載のものに用いるアルカリ水溶液は、水酸化ナトリウム等のアルカリ金属またはアルカリ土類金属の水溶液であるため、ｐＨ１２．５以上のアルカリ水溶液を作るのは困難であり、また、Ｎａイオンが多く卵殻膜以外のミネラル分が含まれ、遊離したアミノ酸はＮａ＋と塩を作りやすく、塩分が含まれることで使用できる用途が限定される。また、この塩分を除去するために陽イオン交換樹脂を用いた複雑な工程が必要になるという問題がある。
However, the method described in Patent Document 1 has a problem in that the protease is very expensive, resulting in high production costs.
In addition, the alkaline aqueous solution used in the method described in Patent Document 2 is an aqueous solution of an alkali metal or alkaline earth metal such as sodium hydroxide, so it is difficult to produce an alkaline aqueous solution with a pH of 12.5 or more, and it contains a lot of Na ions and minerals other than the eggshell membrane, and the released amino acids tend to form salts with Na+, so the inclusion of salts limits the applications in which it can be used. Another problem is that a complicated process using a cation exchange resin is required to remove the salts.
本発明は、上記問題点を解決して、低コスト、かつ、塩分濃度の低い加水分解卵殻膜を製造することを課題とする。 The objective of the present invention is to solve the above problems and produce hydrolyzed eggshell membrane at low cost and with a low salt concentration.
上記課題を解決するために本発明は、陽イオン交換樹脂を用いた脱塩処理を行わない加水分解卵殻膜の製造方法であって、
破砕された卵殻膜を電解アルカリ水中で加水分解する加水分解工程と、
前記加水分解工程で加水分解された破砕された卵殻膜を含む電解アルカリ水に酸を添加する酸添加工程と、
前記酸添加工程で得られた水溶液から加水分解卵殻膜の粉末を回収する加水分解卵殻膜回収工程と、を備え、
前記加水分解工程における前記電解アルカリ水は、ｐH１２．５以上、かつ、Ｎａイオンが０．２％以下であることを特徴とする加水分解卵殻膜の製造方法を提供するものである。
In order to solve the above problems, the present invention provides a method for producing hydrolyzed eggshell membrane without performing a desalting treatment using a cation exchange resin, comprising the steps of:
a hydrolysis step of hydrolyzing the crushed eggshell membranes in electrolyzed alkaline water ;
an acid addition step of adding acid to the electrolyzed alkaline water containing the crushed eggshell membranes hydrolyzed in the hydrolysis step;
and a hydrolyzed eggshell membrane recovery step of recovering a hydrolyzed eggshell membrane powder from the aqueous solution obtained in the acid addition step.
The electrolyzed alkaline water used in the hydrolysis step has a pH of 12.5 or higher and a Na ion content of 0.2% or less.
この構成により、電解アルカリ水中で破砕された卵殻膜を加水分解することで、塩分を除去する複雑な工程を経ることなく、低コスト、かつ、塩分濃度の低い加水分解卵殻膜を製造することができる。 With this configuration, by hydrolyzing the crushed eggshell membranes in electrolyzed alkaline water, it is possible to produce hydrolyzed eggshell membranes with a low salt concentration at low cost without going through a complicated process of removing salt .
加水分解卵殻膜の製造方法であって、前記酸添加工程で得られた水溶液は、ｐH５～７．１である構成としてもよい。 In the method for producing hydrolyzed eggshell membrane, the aqueous solution obtained in the acid addition step may have a pH of 5 to 7.1.
この構成により、様々な用途に加水分解卵殻膜を利用できる。 This composition allows hydrolyzed eggshell membrane to be used for a variety of purposes.
加水分解卵殻膜の製造方法であって、前記加水分解工程では、破砕された卵殻膜を含む電解アルカリ水を加熱する構成としてもよい。 In the method for producing hydrolyzed eggshell membrane, the hydrolysis step may be configured to heat electrolyzed alkaline water containing crushed eggshell membranes .
この構成により、卵殻膜を効率よく加水分解することができる。 This configuration allows the eggshell membrane to be hydrolyzed efficiently.
加水分解卵殻膜の製造方法であって、前記加水分解卵殻膜回収工程は、ポリプロピレンのナノファイバーフィルタで夾雑物を濾過して、加水分解卵殻膜の粉末を回収する構成としてもよい。 In the method for producing hydrolyzed eggshell membrane, the hydrolyzed eggshell membrane recovery step may be configured to filter out impurities using a polypropylene nanofiber filter and recover hydrolyzed eggshell membrane powder.
この構成により、確実に加水分解卵殻膜の粉末を回収することができる。 This configuration ensures that hydrolyzed eggshell membrane powder can be collected.
加水分解卵殻膜の製造方法であって、前記酸添加工程で破砕された卵殻膜を含む電解アルカリ水に添加する酸は、酸性電解水である構成してもよい。 In the method for producing hydrolyzed eggshell membranes, the acid added to the electrolyzed alkaline water containing the crushed eggshell membranes in the acid addition step may be acidic electrolyzed water.
この構成により、不純物の少ない酸性電解水を用いることで、クリアな加水分解卵殻膜を得ることができる。 With this configuration, clear hydrolyzed eggshell membrane can be obtained by using acidic electrolyzed water with few impurities.
本発明の加水分解卵殻膜の製造方法により、低コスト、かつ、塩分濃度の低い加水分解卵殻膜を製造することができる。 The method for producing hydrolyzed eggshell membrane of the present invention makes it possible to produce hydrolyzed eggshell membrane at low cost and with a low salt concentration.
本発明の加水分解卵殻膜の製造方法は、次の工程を経ることで、低コスト、かつ、塩分濃度の低い加水分解卵殻膜を製造することができる。
（１）加水分解工程
（２）酸添加工程
（３）加水分解卵殻膜回収工程
The method for producing hydrolyzed eggshell membrane of the present invention can produce hydrolyzed eggshell membrane at low cost and with a low salt concentration by going through the following steps.
(1) Hydrolysis step (2) Acid addition step (3) Hydrolyzed eggshell membrane recovery step
まず、（１）加水分解工程を説明する。
電解アルカリ水を用意し、この電解アルカリ水の中に細かく破砕された卵殻膜を投入する。電解アルカリ水は、水酸化ナトリウム０．１８％アルカリ性を換算した値でｐＨ１２．５～１３であり、また、含有塩（Ｎａイオン）が０．２％以下である。ｐＨ値が低いと卵殻膜を加水分解する時間が長くなったり、加水分解することが困難になったりする場合がある。また、含有塩（Ｎａイオン）が多いと、卵殻膜以外のミネラル分が含まれ、遊離したアミノ酸はＮａ＋と塩を作りやすく、塩分が含まれることで使用できる用途が限定される。また、この塩分を除去するために陽イオン交換樹脂を用いた複雑な工程が必要になるという問題がある。
First, (1) the hydrolysis step will be described.
Electrolyzed alkaline water is prepared, and finely crushed eggshell membrane is put into the electrolyzed alkaline water. The electrolyzed alkaline water has a pH of 12.5 to 13, calculated as an alkalinity of 0.18% sodium hydroxide, and contains 0.2% or less salt (Na ion). If the pH value is low, the time required to hydrolyze the eggshell membrane may be long or it may be difficult to hydrolyze the eggshell membrane. In addition, if the salt content (Na ion) is high, minerals other than the eggshell membrane are contained, and the liberated amino acids are likely to form salts with Na+, and the salt content limits the applications in which the product can be used. In addition, there is a problem that a complicated process using a cation exchange resin is required to remove the salt.
本発明の加水分解卵殻膜の製造方法では、電解アルカリ水を用いて卵殻膜の加水分解を行うため、アルカリ性がｐＨ１２．５～１３であり、また、含有塩（Ｎａイオン）が０．２％以下であるため上記の問題点を解決して、効率的に卵殻膜の加水分解を行うことができる。 In the method for producing hydrolyzed eggshell membrane of the present invention, electrolyzed alkaline water is used to hydrolyze eggshell membrane, so the alkalinity is pH 12.5 to 13 and the salt content (Na ions) is 0.2% or less, solving the above problems and enabling efficient hydrolysis of eggshell membrane.
卵殻膜を細かく破砕するには、卵殻膜が卵殻に密着している状態で、公知の破砕機により、５～７μｍに破砕してから卵殻と卵殻膜とを分離すればよい。細かく粉砕した卵殻膜を電解アルカリ水に投入して数時間撹拌すると卵殻膜が加水分解される。このとき、７０～９０℃に加熱してもよい。これにより加水分解が加速される。 To finely crush the eggshell membrane, it is sufficient to crush the eggshell membrane to 5-7 μm using a known crusher while it is still in contact with the eggshell, and then separate the eggshell membrane from the eggshell. The finely crushed eggshell membrane is placed in electrolyzed alkaline water and stirred for several hours, causing the eggshell membrane to hydrolyze. At this time, the water may be heated to 70-90°C, which will accelerate the hydrolysis.
次に、（２）酸添加工程を説明する。
酸添加工程では、（１）加水分解工程で加水分解された卵殻膜粉末を含む電解アルカリ水に酸を添加してｐＨ７．１程度に下げる。酸はクエン酸でもよいし、酸性電解液であってもよい。酸を添加した後のｐＨは、７．１が最も好ましいが、５～７．１程度であってもよい。
Next, (2) the acid addition step will be described.
In the acid addition step, an acid is added to the electrolytic alkaline water containing the eggshell membrane powder hydrolyzed in the (1) hydrolysis step to lower the pH to about 7.1. The acid may be citric acid or an acidic electrolyte. The pH after the acid addition is most preferably 7.1, but may be about 5 to 7.1.
次に、（３）加水分解卵殻膜回収工程を説明する。
加水分解卵殻膜回収工程では、水分と水分に含まれる夾雑物を除去することで加水分解卵殻膜を回収することができる。具体的には、酸を添加した水溶液を静置して、沈殿物を除いた上澄み液をとった後、加熱して回収してもよいし、酸を添加した水溶液をフィルタで濾過して夾雑物を除去して回収してもよい。
Next, (3) the hydrolyzed eggshell membrane recovery step will be described.
In the hydrolyzed eggshell membrane recovery step, the hydrolyzed eggshell membrane can be recovered by removing water and impurities contained in the water. Specifically, the aqueous solution to which the acid has been added may be left to stand, the precipitate removed, and the supernatant liquid taken, and then heated to recover the membrane, or the aqueous solution to which the acid has been added may be filtered through a filter to remove the impurities and recover the membrane.
乾燥した卵殻膜粉末（平均粒径 ７μm）１．０２ｇにケミコート社製電解アルカリ水（クリーンシュシュ：pH１２．５～１３）を１２．５５ｇ加え、７０～７５℃の湯煎で時々振り混ぜながら４時間加熱することで加水分解工程を実施した。 12.55 g of electrolytic alkaline water (Clean Shushu: pH 12.5-13) manufactured by Chemicoat was added to 1.02 g of dried eggshell membrane powder (average particle size 7 μm), and the mixture was heated in a water bath at 70-75°C for 4 hours while occasionally shaking and mixing, to carry out the hydrolysis process.
その後、酸添加工程では、クエン酸を加えてｐＨ７．１とした。そして１晩静置後の上澄み液を取り（６．８ｇ）、湯煎で加熱し溶媒を除去することで加水分解卵殻膜回収工程を実施した。残渣０．０７gであった。この淡黄色粉末を卵殻膜加水分解物とした。この粉末は水に溶解した。 In the acid addition process, citric acid was added to adjust the pH to 7.1. After leaving it to stand overnight, the supernatant liquid was collected (6.8 g) and heated in a hot water bath to remove the solvent, thereby carrying out the hydrolyzed eggshell membrane recovery process. The residue was 0.07 g. This pale yellow powder was used as the eggshell membrane hydrolysate. This powder dissolved in water.
乾燥した卵殻膜粉末（平均粒径 ７μm）１．０２ｇにケミコート社製電解アルカリ水（クリーンシュシュ：pH１２．５～１３）を１２．５５ｇ加え、７０～７５℃の湯煎で時々振り混ぜながら加水分解工程を実施した。 12.55 g of electrolytic alkaline water (Clean Shushu: pH 12.5-13) manufactured by Chemicoat was added to 1.02 g of dried eggshell membrane powder (average particle size 7 μm), and the hydrolysis process was carried out in a hot water bath at 70-75°C while occasionally shaking and mixing.
その後、酸添加工程では、酸性電解水を加えてｐＨ７．１とした。そして１晩静置後の上澄み液を取り（６．８ｇ）、湯煎で加熱し溶媒を除去することで加水分解卵殻膜回収工程を実施して、卵殻膜加水分解物を回収した。 Then, in the acid addition process, acidic electrolyzed water was added to adjust the pH to 7.1. After leaving it to stand overnight, the supernatant was collected (6.8 g) and heated in a hot water bath to remove the solvent, thereby carrying out the hydrolyzed eggshell membrane recovery process and recovering the eggshell membrane hydrolyzate.
乾燥した卵殻膜粉末（平均粒径 ７μm）１．０２ｇにケミコート社製電解アルカリ水（クリーンシュシュ：pH１２．５～１３）を１２．５５ｇ加え、７０～７５℃の湯煎で時々振り混ぜながら加水分解工程を実施した。 12.55 g of electrolytic alkaline water (Clean Shushu: pH 12.5-13) manufactured by Chemicoat was added to 1.02 g of dried eggshell membrane powder (average particle size 7 μm), and the hydrolysis process was carried out in a hot water bath at 70-75°C while occasionally shaking and mixing.
その後、酸添加工程では、クエン酸を加えてｐＨ７．１とした。その後、ポリプロピレンのナノファイバーフィルタで夾雑物を濾過して、加水分解卵殻膜の粉末を回収することで加水分解卵殻膜回収工程を実施した。 Then, in the acid addition process, citric acid was added to adjust the pH to 7.1. Then, the hydrolyzed eggshell membrane recovery process was carried out by filtering impurities with a polypropylene nanofiber filter and recovering the hydrolyzed eggshell membrane powder.
このように、本発明においては、電解アルカリ水中で卵殻膜粉末を加水分解する加水分解工程と、
前記加水分解工程で加水分解された卵殻膜粉末を含む電解アルカリ水に酸を添加する酸添加工程と、
前記酸添加工程で得られた水溶液から加水分解卵殻膜の粉末を回収する加水分解卵殻膜回収工程と、を備えたことを特徴とする加水分解卵殻膜の製造方法により、高価な蛋白分解酵素を用いることなく、低コスト、かつ、塩分濃度の低い加水分解卵殻膜を製造することができる。
Thus, in the present invention, the hydrolysis step of hydrolyzing eggshell membrane powder in electrolyzed alkaline water,
an acid addition step of adding an acid to the electrolyzed alkaline water containing the eggshell membrane powder hydrolyzed in the hydrolysis step;
By using this method for producing hydrolyzed eggshell membrane, which is characterized by comprising a hydrolyzed eggshell membrane recovery step of recovering hydrolyzed eggshell membrane powder from the aqueous solution obtained in the acid addition step, it is possible to produce hydrolyzed eggshell membranes at low cost and with a low salt concentration without using expensive proteolytic enzymes.
本発明における加水分解卵殻膜の製造方法は、加水分解卵殻膜の製造分野に広く用いることができる。
The method for producing hydrolyzed eggshell membrane of the present invention can be widely used in the field of hydrolyzed eggshell membrane production.
Claims (5)
破砕された卵殻膜を電解アルカリ水中で加水分解する加水分解工程と、
前記加水分解工程で加水分解された破砕された卵殻膜を含む電解アルカリ水に酸を添加する酸添加工程と、
前記酸添加工程で得られた水溶液から加水分解卵殻膜の粉末を回収する加水分解卵殻膜回収工程と、を備え、
前記加水分解工程における前記電解アルカリ水は、ｐH１２．５以上、かつ、Ｎａイオンが０．２％以下であることを特徴とする加水分解卵殻膜の製造方法。 A method for producing hydrolyzed eggshell membrane without desalting using a cation exchange resin, comprising:
a hydrolysis step of hydrolyzing the crushed eggshell membranes in electrolyzed alkaline water ;
an acid addition step of adding acid to the electrolyzed alkaline water containing the crushed eggshell membranes hydrolyzed in the hydrolysis step;
and a hydrolyzed eggshell membrane recovery step of recovering a hydrolyzed eggshell membrane powder from the aqueous solution obtained in the acid addition step.
The method for producing hydrolyzed eggshell membrane, wherein the electrolyzed alkaline water in the hydrolysis step has a pH of 12.5 or higher and a Na ion content of 0.2% or less.
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| JP2016098206A (en) | 2014-11-25 | 2016-05-30 | 長谷部 由紀夫 | Hydrolyzed eggshell membrane powder and method for producing the same |
| JP2017119649A (en) | 2015-12-28 | 2017-07-06 | 株式会社 アルマード | Hair restorer and composition for external use containing the same |
| JP2018039765A (en) | 2016-09-09 | 2018-03-15 | 株式会社 アルマード | Gel dentifrice |
| JP2019137619A (en) | 2018-02-07 | 2019-08-22 | 長谷部 由紀夫 | Hair restoration and hair growth promoter containing hydrolyzed eggshell membrane as an active ingredient |
| JP2019137634A (en) | 2018-02-09 | 2019-08-22 | 株式会社 アルマード | Cosmetic liquid containing hydrolyzed eggshell membrane component |
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