JP7574100B2 - Skin Pre-Treatment Agent - Google Patents
Skin Pre-Treatment Agent Download PDFInfo
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- JP7574100B2 JP7574100B2 JP2021022867A JP2021022867A JP7574100B2 JP 7574100 B2 JP7574100 B2 JP 7574100B2 JP 2021022867 A JP2021022867 A JP 2021022867A JP 2021022867 A JP2021022867 A JP 2021022867A JP 7574100 B2 JP7574100 B2 JP 7574100B2
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- skin
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- pretreatment agent
- lotion
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- 238000002203 pretreatment Methods 0.000 title description 4
- 239000003795 chemical substances by application Substances 0.000 claims description 26
- -1 alkyl glucoside Chemical class 0.000 claims description 14
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 12
- 239000006210 lotion Substances 0.000 claims description 10
- 229930182478 glucoside Natural products 0.000 claims description 9
- 150000004676 glycans Chemical class 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 7
- 229920001282 polysaccharide Polymers 0.000 claims description 7
- 239000005017 polysaccharide Substances 0.000 claims description 7
- 241000908178 Tremella fuciformis Species 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- NJNWCIAPVGRBHO-UHFFFAOYSA-N 2-hydroxyethyl-dimethyl-[(oxo-$l^{5}-phosphanylidyne)methyl]azanium Chemical group OCC[N+](C)(C)C#P=O NJNWCIAPVGRBHO-UHFFFAOYSA-N 0.000 claims description 5
- 239000002202 Polyethylene glycol Substances 0.000 claims description 5
- HOVAGTYPODGVJG-UVSYOFPXSA-N (3s,5r)-2-(hydroxymethyl)-6-methoxyoxane-3,4,5-triol Chemical compound COC1OC(CO)[C@@H](O)C(O)[C@H]1O HOVAGTYPODGVJG-UVSYOFPXSA-N 0.000 description 7
- HOVAGTYPODGVJG-UHFFFAOYSA-N methyl beta-galactoside Natural products COC1OC(CO)C(O)C(O)C1O HOVAGTYPODGVJG-UHFFFAOYSA-N 0.000 description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 6
- 230000035515 penetration Effects 0.000 description 6
- 239000002537 cosmetic Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 239000002904 solvent Substances 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 229920001577 copolymer Polymers 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- ZSZRUEAFVQITHH-UHFFFAOYSA-N 2-(2-methylprop-2-enoyloxy)ethyl 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CC(=C)C(=O)OCCOP([O-])(=O)OCC[N+](C)(C)C ZSZRUEAFVQITHH-UHFFFAOYSA-N 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- SOGAXMICEFXMKE-UHFFFAOYSA-N alpha-Methyl-n-butyl acrylate Natural products CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 229940058015 1,3-butylene glycol Drugs 0.000 description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 239000004909 Moisturizer Substances 0.000 description 1
- 241000209094 Oryza Species 0.000 description 1
- 239000008118 PEG 6000 Substances 0.000 description 1
- 229920000604 Polyethylene Glycol 200 Polymers 0.000 description 1
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
- 229920002584 Polyethylene Glycol 6000 Polymers 0.000 description 1
- 229920002593 Polyethylene Glycol 800 Polymers 0.000 description 1
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
- 241001506047 Tremella Species 0.000 description 1
- 241000221424 Tremellaceae Species 0.000 description 1
- DRRMRHKHTQRWMB-UHFFFAOYSA-N [3-(2-ethylhexanoyloxy)-2,2-bis(2-ethylhexanoyloxymethyl)propyl] 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(COC(=O)C(CC)CCCC)(COC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DRRMRHKHTQRWMB-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940121363 anti-inflammatory agent Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000008406 cosmetic ingredient Substances 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- RMVRNAXXHCXCLR-UHFFFAOYSA-N ethenyl 2-methylprop-2-enoate;2-hydroxyethyl-dimethyl-[(oxo-$l^{5}-phosphanylidyne)methyl]azanium Chemical compound CC(=C)C(=O)OC=C.OCC[N+](C)(C)C#P=O RMVRNAXXHCXCLR-UHFFFAOYSA-N 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000001333 moisturizer Effects 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- PYJNAPOPMIJKJZ-UHFFFAOYSA-N phosphorylcholine chloride Chemical group [Cl-].C[N+](C)(C)CCOP(O)(O)=O PYJNAPOPMIJKJZ-UHFFFAOYSA-N 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001953 sensory effect Effects 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical class NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Description
本発明は、化粧水等の使用の前に皮膚に塗布することにより、化粧水等の浸透感を高め、肌なじみを良くする皮膚プレトリートメント剤に関する。 The present invention relates to a skin pretreatment agent that, when applied to the skin before using lotion or the like, enhances the penetration of the lotion or the like and improves its compatibility with the skin.
スキンケア化粧料を塗布する前に使用することで経皮吸収を促進するとして、プレトリートメント剤は様々開発されている。これまで、グリセリン、ジプロピレングリコール、ポリオキシエチレンメチルグルコシド、スクワラン及びテトラ２－エチルヘキサン酸ペンタエリスリットを配合することを特徴とする皮膚プレトリートメント剤において、後で使用する化粧水の経皮吸収性が高まること（引用文献１）や、脂肪酸またはその塩、タウリン誘導体またはその塩を含有することを特徴とする経皮吸収促進用プレトリートメント剤（引用文献２）等が開示されている。しかしながら、必ずしも使用感や浸透感において十分満足できるものではなかった。 Various pre-treatment agents have been developed to promote percutaneous absorption when used before applying skin care cosmetics. To date, a skin pre-treatment agent characterized by blending glycerin, dipropylene glycol, polyoxyethylene methyl glucoside, squalane, and pentaerythritol tetra 2-ethylhexanoate has been disclosed that enhances the percutaneous absorption of a lotion to be used later (Reference 1), and a pre-treatment agent for promoting percutaneous absorption characterized by containing a fatty acid or a salt thereof, and a taurine derivative or a salt thereof (Reference 2). However, the feel of use and the feeling of penetration have not necessarily been fully satisfactory.
本発明は、化粧水等の使用の前に皮膚に塗布することにより、化粧水等の浸透感を高め、肌なじみを良くする皮膚プレトリートメント剤を提供することを課題とする。 The present invention aims to provide a skin pretreatment agent that, when applied to the skin before using lotion or the like, enhances the penetration of lotion or the like and improves its compatibility with the skin.
本発明は、下記（Ａ）～（Ｅ）を含有する皮膚プレトリートメント剤を提供する。
（Ａ）グリセリン
（Ｂ）ポリオキシアルキレンアルキルグルコシド
（Ｃ）ホスホリルコリン基含有重合体
（Ｄ）高重合ポリエチレングリコール
（Ｅ）シロキクラゲ多糖体
The present invention provides a skin pretreatment agent containing the following (A) to (E):
(A) Glycerin (B) Polyoxyalkylene alkyl glucoside (C) Phosphorylcholine group-containing polymer (D) Highly polymerized polyethylene glycol (E) Tremella fuciformis polysaccharide
本発明の皮膚プレトリートメント剤は、化粧水等の使用の前に皮膚に塗布することにより、化粧水等の浸透感を高め、肌なじみを良くする効果を発揮する。 The skin pretreatment agent of the present invention, when applied to the skin before using lotion or the like, has the effect of enhancing the penetration of the lotion or the like and improving its compatibility with the skin.
以下本発明を実施するための形態を説明する。 The following describes how to implement the present invention.
［グリセリン］
本発明の皮膚プレトリートメント剤に配合するグリセリンは、通常化粧料に用いられるものであれば、その原料、製造方法、精製方法等は特に限定されない。
[Glycerin]
The glycerin to be blended in the skin pretreatment agent of the present invention is not particularly limited with respect to its raw materials, production method, purification method, etc., so long as it is one that is usually used in cosmetics.
本発明においてグリセリンの配合量は、皮膚プレトリートメント剤全量に対して１～４０質量％が好ましく、さらに１～２５質量％が好ましい。 In the present invention, the amount of glycerin is preferably 1 to 40% by mass, more preferably 1 to 25% by mass, based on the total amount of the skin pretreatment agent.
［ポリオキシアルキレンアルキルグルコシド］
本発明の皮膚プレトリートメント剤に配合するポリオキシアルキレンアルキルグルコシドは、例えば、エチレンオキサイド及びプロピレンオキサイドから選択される１種又は２種のアルキレンオキサイドを、アルキルグルコシドに付加したものを使用することができ、その平均付加モル数としては、１～３０モル程度が好ましい。ポリオキシアルキレンアルキルグルコシドにおけるアルキル基としては、炭素数１～４のものが好ましく、メチル基、エチル基、プロピル基、イソプロピル基等が好ましい例である。ポリオキシアルキレンアルキルグルコシドの好ましい具体例としては、ポリオキシアルキレンメチルグルコシドが挙げられ、より具体的には、ＰＯＥ（１０）メチルグルコシド、ＰＯＥ（２０）メチルグルコシド、ＰＯＰ（１０）メチルグルコシド及びＰＯＰ（２０）メチルグルコシド等が挙げられる。これらのポリオキシアルキレンアルキルグルコシドとしては、肌なじみの良さの観点からＰＯＥ（１０）メチルグルコシドを用いることが最も好ましい。なお、本明細書において、ポリオキシエチレンをＰＯＥと略記し、ポリオキシプロピレンをＰＯＰと略記し、かっこ内の数はその平均付加モル数である。市販品としては、マクビオブライドＭＧ－１０Ｅ、マクビオブライドＭＧ－２０Ｅ、マクビオブライドＭＧ－１０Ｐ（いずれも日油社製）、ＧＬＵＣＡＭＥ－１０ＬＦＧ、ＧＬＵＣＡＭＥＰ－１０（いずれもＬＵＢＲＩＺＯＬＡＤＶＡＮＣＥＤＭＡＴＥＲＩＡＬＳ社製）等が挙げられる。
[Polyoxyalkylene alkyl glucoside]
The polyoxyalkylene alkyl glucoside to be incorporated in the skin pretreatment agent of the present invention may be, for example, an alkyl glucoside to which one or two alkylene oxides selected from ethylene oxide and propylene oxide have been added, and the average number of moles added is preferably about 1 to 30 moles. The alkyl group in the polyoxyalkylene alkyl glucoside is preferably one having 1 to 4 carbon atoms, and preferred examples include a methyl group, an ethyl group, a propyl group, and an isopropyl group. Preferred specific examples of the polyoxyalkylene alkyl glucoside include polyoxyalkylene methyl glucoside, and more specifically, POE(10) methyl glucoside, POE(20) methyl glucoside, POP(10) methyl glucoside, and POP(20) methyl glucoside. Of these polyoxyalkylene alkyl glucosides, it is most preferred to use POE(10) methyl glucoside from the viewpoint of good compatibility with the skin. In this specification, polyoxyethylene is abbreviated as POE, polyoxypropylene is abbreviated as POP, and the number in parentheses is the average number of moles added. Commercially available products include MacBiobride MG-10E, MacBiobride MG-20E, MacBiobride MG-10P (all manufactured by NOF Corp.), GLUCAME-10LFG, GLUCAME P-10 (all manufactured by LUBRIZOLADVANCED MATERIALS), and the like.
本発明においてポリオキシアルキレンアルキルグルコシドの配合量は、皮膚プレトリートメント剤全量に対し、０．０００１～２０質量％が好ましく、さらに０．００１～５質量％が好ましい。 In the present invention, the amount of polyoxyalkylene alkyl glucoside is preferably 0.0001 to 20% by mass, more preferably 0.001 to 5% by mass, based on the total amount of the skin pretreatment agent.
［ホスホリルコリン基含有重合体］
本発明の皮膚プレトリートメント剤に配合するホスホリルコリン基含有重合体は、化粧料に配合し得るものであればいずれのものも使用することができる。１種を単独で、又は２種以上を併用して組み合わせて使用してもよい。かかるホスホリルコリン基含有重合体としては、具体的には、化粧品成分表示名称として、ポリクオタニウム－５１（２－メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ブチル共重合体）、ポリクオタニウム－６５（２－メタクリロイルオキシエチレンホスホリルコリン・メタクリル酸ブチル・メタクリル酸ナトリウム共重合体）、ポリクオタニウム－６４（２－メタクリロイルオキシエチルホスホリルコリン・２－ヒドロキシ－３－メタクリロイルオキシプロピルトリメチルアンモニウム共重合体）、ポリクオタニウム－６１（２－メタクリロイルオキシエチルホスホリルコリン・メタクリル酸ステアリル共重合体）等が挙げられる。本発明においては効果の点からポリクオタニウム－５１を用いることが好ましい。市販品としては、ＬＩＰＩＤＵＲＥ－ＰＭＢ、ＬＩＰＩＤＵＲＥ－Ｂ（いずれも日油社製）等が挙げられる。
[Phosphorylcholine group-containing polymer]
The phosphorylcholine group-containing polymer to be blended in the skin pretreatment agent of the present invention may be any polymer that can be blended in a cosmetic. One type may be used alone, or two or more types may be used in combination. Specific examples of such phosphorylcholine group-containing polymers include, as cosmetic ingredient names, polyquaternium-51 (2-methacryloyloxyethyl phosphorylcholine/butyl methacrylate copolymer), polyquaternium-65 (2-methacryloyloxyethylene phosphorylcholine/butyl methacrylate/sodium methacrylate copolymer), polyquaternium-64 (2-methacryloyloxyethyl phosphorylcholine/2-hydroxy-3-methacryloyloxypropyltrimethylammonium copolymer), polyquaternium-61 (2-methacryloyloxyethyl phosphorylcholine/stearyl methacrylate copolymer), and the like. In the present invention, it is preferable to use polyquaternium-51 from the viewpoint of effect. Commercially available products include LIPIDURE-PMB and LIPIDURE-B (both manufactured by NOF Corporation).
本発明においてホスホリルコリン基含有重合体の配合量は、皮膚プレトリートメント剤全量に対し、０．００００１～５質量％が好ましく、さらに０．００００１～１質量％が好ましい。 In the present invention, the amount of the phosphorylcholine group-containing polymer is preferably 0.00001 to 5% by mass, more preferably 0.00001 to 1% by mass, based on the total amount of the skin pretreatment agent.
［高重合ポリエチレングリコール］
本発明の皮膚プレトリートメント剤に配合する高重合ポリエチレングリコールは、化粧品表示名称でＰＥＧ－１００、ＰＥＧ－１３５、ＰＥＧ－１５０、ＰＥＧ－１８０、ＰＥＧ－２００、ＰＥＧ－２２０、ＰＥＧ－２４０、ＰＥＧ－３５０、ＰＥＧ－４００、ＰＥＧ－４５０、ＰＥＧ－８００、ＰＥＧ－２Ｍ、ＰＥＧ－５Ｍ、ＰＥＧ－７Ｍ、ＰＥＧ－９Ｍ、ＰＥＧ－１４Ｍ、ＰＥＧ－１８Ｍ、ＰＥＧ－２０Ｍ、ＰＥＧ－２３Ｍ、ＰＥＧ－２５Ｍ、ＰＥＧ－４５Ｍ、ＰＥＧ－６５Ｍ、ＰＥＧ－９０Ｍ等が例示される。これらのなかでも、本発明の効果の点からＰＥＧ－１５０を用いることがより好ましい。市販品としてはＰＥＧ ６０００、ＰＥＧ ６０００Ｐ（いずれも日油社製）等が挙げられる。
[Highly polymerized polyethylene glycol]
Examples of the highly polymerized polyethylene glycol to be incorporated in the skin pretreatment agent of the present invention include, in terms of cosmetic name, PEG-100, PEG-135, PEG-150, PEG-180, PEG-200, PEG-220, PEG-240, PEG-350, PEG-400, PEG-450, PEG-800, PEG-2M, PEG-5M, PEG-7M, PEG-9M, PEG-14M, PEG-18M, PEG-20M, PEG-23M, PEG-25M, PEG-45M, PEG-65M, PEG-90M, etc. Among these, it is more preferable to use PEG-150 in terms of the effects of the present invention. Examples of commercially available products include PEG 6000 and PEG 6000P (both manufactured by NOF Corporation).
本発明において高重合ポリエチレングリコールの配合量は、皮膚プレトリートメント剤全量に対し、０．０１～１０質量％が好ましく、さらに０．１～５質量％がより好ましい。 In the present invention, the amount of highly polymerized polyethylene glycol is preferably 0.01 to 10% by mass, and more preferably 0.1 to 5% by mass, based on the total amount of the skin pretreatment agent.
［シロキクラゲ多糖体］
本発明の皮膚プレトリートメント剤に配合するシロキクラゲ多糖体は、シロキクラゲ科（Ｔｒｅｍｅｌｌａｃｅａｅ）に属するキノコから溶媒を用いて抽出される水溶性多糖類である。
[Tremendous fungus polysaccharide]
The Tremella fuciformis polysaccharide incorporated in the skin pretreatment agent of the present invention is a water-soluble polysaccharide extracted with a solvent from a mushroom belonging to the Tremellaceae family.
抽出溶媒としては水、エタノールなどの低級アルコール、１，３－ブチレングリコールやジプロピレングリコール等の多価アルコール等が挙げられる。これらの溶媒は一種又は二種以上を混合して用いてもよい。これらの中でも、水、熱水、又は水と任意の割合で混合可能な溶媒、例えば、エタノールや１，３－ブチレングリコールとの混液を用いるのが好ましく、熱水を用いるのがより好ましい。抽出方法は特に限定されないが、例えば、抽出のための溶媒とシロキクラゲを混合して加温抽出する方法が挙げられる。得られた抽出物はそのまま用いられるか、適宜濃縮したものや噴霧乾燥や凍結乾燥などによって粉末状に乾燥したものを用いることもできる。 Examples of extraction solvents include water, lower alcohols such as ethanol, and polyhydric alcohols such as 1,3-butylene glycol and dipropylene glycol. These solvents may be used alone or in combination of two or more. Of these, it is preferable to use water, hot water, or a solvent that can be mixed with water in any ratio, such as a mixture of ethanol and 1,3-butylene glycol, and it is more preferable to use hot water. There are no particular limitations on the extraction method, but an example is a method in which the extraction solvent is mixed with Tremella fuciformis and extracted by heating. The obtained extract can be used as is, or it can be used after being appropriately concentrated or dried into a powder by spray drying, freeze drying, or the like.
また、市販のものを用いることもでき、例えばＴｒｅｍｏｉｓｔ－ＴＰ、Ｔｒｅｍｏｉｓｔ－ＳＬ（日本精化社製）、白キクラゲ多糖体-Ｐ（オリザ油化社製）、ＨｙａＣａｒｅ Ｔｒｅｍｅｌｌａ（エボニックジャパン社製）等が挙げられる。 Commercially available products can also be used, such as Tremoist-TP and Tremoist-SL (manufactured by Nippon Fine Chemicals), White Jew's Jew's Polysaccharide-P (manufactured by Oryza Oil & Fat Chemical), and HyaCare Tremella (manufactured by Evonik Japan).
本発明におけるシロキクラゲ多糖体の配合量は、皮膚プレトリートメント剤全量に対し、シロキクラゲ多糖体純分として０．００００１～３質量％が好ましく、０．００００５～２質量％がより好ましい。 The amount of Tremella fuciformis polysaccharide in the present invention is preferably 0.00001 to 3 mass% in terms of pure Tremella fuciformis polysaccharide content relative to the total amount of the skin pretreatment agent, and more preferably 0.00005 to 2 mass%.
本発明の皮膚プレトリートメント剤には、上述の成分の他に、通常の化粧料、医薬部外品に用いられる任意成分を、本発明の効果を阻害しない程度に配合することができる。具体的には、紫外線吸収剤、紫外線散乱剤、油剤、界面活性剤、増粘剤、防腐剤、香料、色素、保湿剤、抗酸化剤、抗炎症剤、抗菌剤等を挙げることができる。 In addition to the above-mentioned ingredients, the skin pretreatment agent of the present invention can contain optional ingredients used in ordinary cosmetics and quasi-drugs to the extent that they do not inhibit the effects of the present invention. Specific examples of such ingredients include UV absorbers, UV scattering agents, oils, surfactants, thickeners, preservatives, fragrances, colorants, moisturizers, antioxidants, anti-inflammatory agents, and antibacterial agents.
本発明の皮膚プレトリートメント剤の剤型は、特に限定されず、水系、油系、乳化型等いずれの剤型でもよい。 The formulation of the skin pretreatment agent of the present invention is not particularly limited, and may be any formulation, such as water-based, oil-based, or emulsion-based.
本発明の皮膚プレトリートメント剤は定法により調製することができる。 The skin pretreatment agent of the present invention can be prepared by a conventional method.
以下、実施例により本発明を具体的に説明するが、これにより本発明の範囲が限定されるものではない。なお、以下の実施例において、特に断りのない限り配合量は質量％で示す。 The present invention will be specifically explained below with reference to examples, but the scope of the present invention is not limited thereto. In the following examples, the blending amounts are shown in mass % unless otherwise specified.
［使用感評価］
官能評価専門員３名が、実施例及び比較例にかかる皮膚プレトリートメント剤をそれぞれ独立して使用し、合議により下記の評価を行った。さらに、本発明の皮膚プレトリートメント剤を塗布した後、精製水を塗布したときの評価も同様に行った。
[Usability evaluation]
Three sensory evaluators independently used the skin pretreatment agents according to the Examples and Comparative Examples and conducted the following evaluations in a consensus manner. In addition, an evaluation was also conducted in the same manner when purified water was applied after application of the skin pretreatment agent of the present invention.
［評価基準］浸透感・肌なじみ
非常に良い：◎
良い：〇
悪い：△
非常に悪い：×
[Evaluation criteria] Penetration and skin affinity: Very good: ◎
Good: 〇 Bad: △
Very bad: ×
表１および表２に示す処方にて、本発明の実施例及び比較例となる皮膚プレトリートメント剤を常法により調製した。 The skin pretreatment agents of the present invention and comparative examples were prepared by conventional methods according to the formulations shown in Tables 1 and 2.
表１および表２に示した通り、本願発明の皮膚プレトリートメント剤は化粧水等の使用の前に皮膚に塗布することにより、化粧水等の浸透感を高め、肌なじみを良くする効果を発揮することが確認された。 As shown in Tables 1 and 2, it has been confirmed that the skin pretreatment agent of the present invention, when applied to the skin before using lotion or the like, has the effect of enhancing the penetration of lotion or the like and improving its compatibility with the skin.
Claims (1)
（Ａ）グリセリン
（Ｂ）ポリオキシアルキレンアルキルグルコシド
（Ｃ）ホスホリルコリン基含有重合体
（Ｄ）高重合ポリエチレングリコール
（Ｅ）シロキクラゲ多糖体 A skin pretreatment agent containing the following (A) to (E) and to be applied to the skin before using a lotion :
(A) Glycerin (B) Polyoxyalkylene alkyl glucoside (C) Phosphorylcholine group-containing polymer (D) Highly polymerized polyethylene glycol (E) Tremella fuciformis polysaccharide
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012111722A (en) | 2010-11-26 | 2012-06-14 | Noevir Co Ltd | Skin pretreatment agent |
| JP2017061432A (en) | 2015-09-25 | 2017-03-30 | 株式会社ノエビア | Skin external preparation |
| JP2018104399A (en) | 2016-12-28 | 2018-07-05 | 花王株式会社 | Oil-in-water emulsion composition |
| JP2018188423A (en) | 2017-05-09 | 2018-11-29 | 株式会社コーセー | Composition |
| JP2019001723A (en) | 2017-06-12 | 2019-01-10 | 株式会社ナリス化粧品 | Cosmetic composition |
| JP2019131547A (en) | 2018-01-31 | 2019-08-08 | 株式会社コーセー | Aqueous composition |
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012111722A (en) | 2010-11-26 | 2012-06-14 | Noevir Co Ltd | Skin pretreatment agent |
| JP2017061432A (en) | 2015-09-25 | 2017-03-30 | 株式会社ノエビア | Skin external preparation |
| JP2018104399A (en) | 2016-12-28 | 2018-07-05 | 花王株式会社 | Oil-in-water emulsion composition |
| JP2018188423A (en) | 2017-05-09 | 2018-11-29 | 株式会社コーセー | Composition |
| JP2019001723A (en) | 2017-06-12 | 2019-01-10 | 株式会社ナリス化粧品 | Cosmetic composition |
| JP2019131547A (en) | 2018-01-31 | 2019-08-08 | 株式会社コーセー | Aqueous composition |
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