JP7576906B2 - Imaging device and method of operating an imaging device - Patents.com - Google Patents

Description

The present invention relates to an imaging device and a method of operating an imaging device .

A technique called near-infrared fluorescence imaging is used for angiography in surgical procedures. In this near-infrared fluorescence imaging, the fluorescent dye indocyanine green (ICG) is administered to the affected area by injection using an injector or the like. When the indocyanine green is irradiated with near-infrared light with a wavelength of about 600 to 850 nm (nanometers) as excitation light, the indocyanine green emits near-infrared fluorescence with a wavelength of about 750 to 900 nm. This fluorescence is captured by an imaging element capable of detecting near-infrared light, and the image is displayed on a display unit such as a liquid crystal display panel. This near-infrared fluorescence imaging makes it possible to observe blood vessels and lymphatic vessels that exist at a depth of about 20 mm from the body surface.

For example, Patent Document 1 discloses a method of obtaining a graph showing the change in fluorescence intensity over time, and generating a color image (color map) based on various indices such as the slope of the graph, the time to the peak, and the area. When the method described in Patent Document 1 is used, the color image becomes an image in which the color changes continuously according to, for example, the blood circulation state of the subject. A doctor can refer to this color image to determine where the blood circulation state is deteriorating, that is, where in the blood vessels surgical procedures should be performed.

Patent No. 5918532

For example, when it is desired to grasp the thickness of blood vessels or the size of other organs, this cannot be done accurately using only color images obtained using the method described in Patent Document 1.
The present invention has been made to solve the above-mentioned problems, and has an object to provide an imaging device and an operating method of an imaging device that can accurately grasp the size of a measurement object when the size of the measurement object is to be grasped.

A first aspect of the present invention relates to an imaging device comprising a first light source that emits white light toward a subject, a second light source that emits excitation light toward the subject for exciting a fluorescent dye injected into the subject , a first imaging unit that acquires a visible image by imaging the subject irradiated with white light, a second imaging unit that acquires a fluorescent image by imaging fluorescence emitted from the fluorescent dye, an image display unit that displays the visible image and the fluorescent image, a user interface for inputting a desired measurement line on the fluorescent image displayed on the image display unit, and a distance calculation unit that calculates the length of the measurement line based on the length of a reference scale that is positioned adjacent to the subject and does not contain fluorescent material, the image being captured by the first imaging unit, and the image display unit displays the length of the measurement line calculated by the distance calculation unit.

A second aspect of the present invention relates to an imaging device comprising a first light source that emits white light toward a subject, a second light source that emits excitation light toward the subject for exciting a fluorescent dye injected into the subject , a first imaging unit that acquires a visible image by imaging the subject irradiated with the white light, a second imaging unit that acquires a fluorescent image by imaging fluorescence emitted from the fluorescent dye, an image display unit that displays the visible image and the fluorescent image, a user interface that inputs a reference line along a standard scale that is positioned adjacent to the subject and does not contain fluorescent material on the visible image displayed on the image display unit and inputs a desired measurement line on the fluorescent image displayed on the image display unit, and a distance calculation unit that calculates the length of the measurement line based on the length of the reference line, wherein the image display unit displays the length of the measurement line calculated by the distance calculation unit.

A third aspect of the present invention relates to a method for operating an imaging device, the method including the steps of: a first light source emitting white light toward a subject; a second light source emitting excitation light toward the subject for exciting a fluorescent dye injected into the subject; a first imaging unit acquiring a visible image by imaging the subject irradiated with the white light; a second imaging unit acquiring a fluorescent image by imaging the fluorescence emitted from the fluorescent dye; an image display unit displaying the visible image and the fluorescent image; a user interface inputting a desired measurement line on the fluorescent image displayed on the image display unit; a distance calculation unit calculating the length of the measurement line based on the length of a standard scale that is arranged in close proximity to the subject and does not contain a fluorescent material , which is imaged in the step of acquiring the visible image; and a display unit displaying the length of the measurement line calculated by the distance calculation unit.

A fourth aspect of the present invention relates to a method for operating an imaging device, including the steps of: a first light source emitting white light toward a subject; a second light source emitting excitation light toward the subject for exciting a fluorescent dye injected into the subject; a first imaging unit acquiring a visible image by imaging the subject irradiated with the white light; a second imaging unit acquiring a fluorescent image by imaging the fluorescence emitted from the fluorescent dye; an image display unit displaying the visible image and the fluorescent image ; a user interface inputting, on the visible image displayed on the image display unit, a reference line along a standard scale that is arranged in proximity to the subject and does not contain fluorescent material , and inputting a desired measurement line on the fluorescent image displayed on the image display unit; a distance calculation unit calculating a length of the measurement line based on the length of the reference line, the standard scale being imaged in the step of acquiring the visible image ; and a display on the image display unit of the length of the measurement line calculated by the distance calculation unit.

According to the present invention, when there is a measurement object whose size is to be ascertained, the size of the measurement object can be accurately ascertained.

FIG. 1 is a perspective view showing an embodiment of an imaging device of the present invention. FIG. 2 is a side view of the imaging device shown in FIG. FIG. 3 is a plan view of the imaging device shown in FIG. FIG. 4 is a block diagram showing a main control system of the imaging apparatus shown in FIG. FIG. 5 is a diagram showing the steps carried out by the imaging apparatus shown in FIG. FIG. 6 is an example of an image displayed on the image display unit included in the imaging device shown in FIG.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS An imaging apparatus and an imaging method according to the present invention will now be described in detail with reference to preferred embodiments shown in the accompanying drawings.
FIG. 1 is a perspective view showing an embodiment of the imaging device of the present invention. FIG. 2 is a side view of the imaging device shown in FIG. 1. FIG. 3 is a plan view of the imaging device shown in FIG. 1. FIG. 4 is a block diagram showing a main control system of the imaging device shown in FIG. 1. FIG. 5 is a diagram showing the steps executed in the imaging device shown in FIG. 1 in order. FIG. 6 is an example of an image displayed on an image display unit provided in the imaging device shown in FIG. 1. In the following, for convenience of explanation, the upper side in FIG. 1, FIG. 2 and FIG. 6 will be referred to as "upper" and the lower side as "lower".

The imaging device 1 shown in FIG. 1 is a device for irradiating excitation light onto indocyanine green (ICG) as a fluorescent dye injected into the body of a subject ST and capturing the fluorescence emitted from this indocyanine green. By using the imaging device 1, for example, the blood circulation state of the subject ST can be accurately grasped when performing a surgical operation on the subject ST.

The imaging device 1 comprises a dolly 11 with four wheels 13, an arm mechanism 30 disposed on the top surface of the dolly 11 near the front in the direction of travel of the dolly 11 (to the left in Figs. 2 and 3), an illumination and photography unit 12 disposed on the arm mechanism 30 via a sub-arm 41, and an image display unit 15 serving as a monitor. A handle 14 is attached to the rear of the dolly 11 in the direction of travel, and is used when moving the dolly 11. In addition, a recess 16 is formed on the top surface of the dolly 11 for mounting a remote control for remotely operating the imaging device 1.

As shown in FIG. 5, the imaging device 1 can execute an imaging method including a white light irradiation process, an excitation light irradiation process, a visible image acquisition process, a fluorescent image acquisition process, a recording process, an image display process, a line input process, a length calculation process, and a length display process in the order of steps.

The arm mechanism 30 described above is disposed on the front side in the traveling direction of the trolley 11. This arm mechanism 30 has a first arm member 31 connected by a hinge portion 33 to a support portion 37 disposed on a support pillar 36 erected on the front side in the traveling direction of the trolley 11. This first arm member 31 is capable of swinging relative to the trolley 11 via the support pillar 36 and the support portion 37 by the action of the hinge portion 33. The image display unit 15 described above is attached to the support pillar 36.

The second arm member 32 is connected to the upper end of the first arm member 31 by a hinge portion 34. The second arm member 32 is able to swing relative to the first arm member 31 by the action of the hinge portion 34. As a result, the first arm member 31 and the second arm member 32 can take a shooting position in which the first arm member 31 and the second arm member 32 are open at a predetermined angle around the hinge portion 34, which is the connecting portion between the first arm member 31 and the second arm member 32, as shown by the imaginary line with the symbol C in FIG. 2, and a standby position in which the first arm member 31 and the second arm member 32 are close to each other, as shown by the solid line with the symbol A in FIGS. 1 to 3.

A support section 43 is connected to the lower end of the second arm member 32 by a hinge section 35. This support section 43 is able to swing relative to the second arm member 32 by the action of the hinge section 35. A rotating shaft 42 is supported by this support section 43. The sub-arm 41 supporting the lighting/photography section 12 rotates around the rotating shaft 42 disposed at the tip of the second arm member 32. Therefore, by the rotation of this sub-arm 41, the lighting/photography section 12 moves between a position forward in the traveling direction of the dolly 11 with respect to the arm mechanism 30 for taking a shooting posture or a standby posture, as shown by the solid line with the symbol A in Figs. 1 to 3, or the virtual line with the symbol C in Fig. 2, and a position backward in the traveling direction of the dolly 11 with respect to the arm mechanism 30, which is the posture when moving the dolly 11, as shown by the virtual line with the symbol B in Figs. 2 and 3.

4, the illumination and photography unit 12 includes a light source unit 24, a light source control unit 25, a zoom lens 26, a prism 27, a white light sensor 28, and an excitation light sensor 29. When using the imaging device 1, it is preferable to place the illumination and photography unit 12 at a distance of about several tens of centimeters from the affected area of the subject ST.
The light source section 24 includes a first light source 241 which is a white light source, and a second light source 242 which is an excitation light source.
The first light source 241 emits white light. This makes it possible to perform a white light irradiation step of irradiating the white light toward the subject ST. Then, this white light is reflected from the subject ST as reflected light.

The second light source 242 irradiates excitation light to excite the fluorescent dye. This allows an excitation light irradiation process to be performed in which excitation light to excite the fluorescent dye is irradiated toward the subject ST to whom the fluorescent dye has been injected or administered. When the fluorescent dye is indocyanine green, it is preferable to use near-infrared light with a wavelength of, for example, 810 nm as the excitation light to excite the indocyanine green. When indocyanine green is irradiated with near-infrared light of 810 nm, near-infrared light with a peak of about 845 nm is emitted as fluorescence.

The light source control unit 25 has a function of controlling the lighting of the first light source 241. This function allows the first light source 241 to emit white light and stop emitting the white light. The light source control unit 25 also has a function of controlling the lighting of the second light source 242. This function allows the second light source 242 to emit excitation light and stop emitting the excitation light. The light source control unit 25 is composed of, for example, a CPU, etc.

White light, which is light reflected by the specimen ST, and fluorescent light, which is near-infrared light generated from indocyanine green in the specimen ST, are incident on the zoom lens 26. Then, by this zoom lens 26, the white light is focused on a white light sensor 28, and the fluorescent light is focused on an excitation light sensor 29.
The light from the zoom lens 26, i.e., the white light and the fluorescent light, is incident on the prism 27 together. The incident white light and the fluorescent light are separated by the prism 27, so that the white light can be directed toward a white light sensor 28 and the fluorescent light can be directed toward an excitation light sensor 29.

The white light sensor 28 detects a portion of the white light separated by the prism 27. The excitation light sensor 29 detects a portion of the near-infrared light (excitation light) separated by the prism 27.
4, the imaging device 1 includes an image forming unit 17, an image combining unit 18, a storage unit 19, a recording unit 20, and an operation unit 10. These units are arranged on a dolly 11.

The image forming unit 17 receives the white light detected by the white light sensor 28 and the near-infrared fluorescence detected by the excitation light sensor 29. The image forming unit 17 forms the white light detected by the white light sensor 28 as a 24-bit (=3×8) visible image IM1 composed of three colors, RGB (red, green, blue). The image forming unit 17 also forms the fluorescence detected by the excitation light sensor 29 as an 8-bit fluorescent image IM2. Thus, in this embodiment, the image forming unit 17 functions as a first imaging unit 171, which is a visible image capturing unit that captures the visible image IM1 by capturing the subject ST irradiated with white light, and a second imaging unit 172, which is a fluorescent image capturing unit that captures the fluorescent image IM2 by capturing the fluorescent dye-generated fluorescence.
The first imaging unit 171 performs a visible image acquiring process of acquiring a visible image IM1 by capturing an image of the subject ST irradiated with white light, while the second imaging unit 172 performs a fluorescent image acquiring process of acquiring a fluorescent image IM2 by capturing an image of fluorescence emitted from a fluorescent dye.

The image synthesis unit 18 synthesizes the visible image IM1 formed by the image formation unit 17 using white light and the fluorescent image IM2 formed by fluorescent light to form (generate) a synthetic image IM3.
6, the visible image IM1, the fluorescent image IM2, and the composite image IM3 are displayed together on the image display unit 15. This allows an image display step to be performed in which the visible image IM1, the fluorescent image IM2, and the composite image IM3 are displayed on the image display unit 15. In this embodiment, the image display unit 15 is divided into a first display unit 151 that displays the visible image IM1, a second display unit 152 that displays the fluorescent image IM2, and a third display unit 153 that displays the composite image IM3. By observing the composite image IM3 in the third display unit 153, the doctor can accurately grasp the blood circulation state of the subject ST, and can also accurately determine the portion to be cut of the blood vessel, i.e., the cutting line, based on the blood circulation state.

The storage unit 19 is configured to store the white light (signal) detected by the white light sensor 28 and the fluorescent light (signal) detected by the excitation light sensor 29 .
The recording unit 20 is configured to record the images displayed on the image display unit 15. This allows a recording process to be performed in which the visible image IM1, the fluorescent image IM2, and the composite image IM3 are recorded. The doctor can then review any of the recorded visible image IM1, the fluorescent image IM2, and the composite image IM3 on the image display unit 15 as necessary, thereby enabling the doctor to perform surgery accurately.
The operation unit 10 is a user interface for operating the imaging device 1. For example, the operation unit 10 is configured to operate the irradiation of light from the light source unit 24, stopping the irradiation, adjusting the brightness and sensitivity, and the display method of the image displayed on the image display unit 15.

As described above, by using the imaging device 1, it is possible to grasp the blood circulation state of the subject ST when performing a surgical operation on the subject ST. Furthermore, in a surgical operation, it may be desired to grasp, for example, the thickness of blood vessels or the size of an organ. Thus, when there is a measurement object MO whose size is to be grasped, the imaging device 1 is configured to be able to grasp the size of the measurement object MO. The configuration and operation are described below. The configuration and operation are described below. Note that, in this embodiment, the measurement object MO is exemplified by the "stomach," but is not limited to this.

As shown in FIG. 6, the imaging device 1 includes a standard scale 50 that is placed in close proximity to the subject ST. There are no particular limitations on the standard scale 50; for example, if it is desired to measure the width of the stomach, which is the measurement object MO, a straight ruler is preferable, but depending on the measurement object MO, other measuring instruments such as a protractor may be used.

The standard scale 50 is placed, for example, on the chest of the subject ST. Then, in the visible image acquisition process, the subject ST and the standard scale 50 on the subject ST are photographed while being irradiated with white light. This makes it possible to acquire a visible image IM1 that captures the subject ST and the standard scale 50. The visible image IM1 is displayed on the first display section 151 of the image display unit 15.

The operation unit 10, which is a user interface, includes a mouse (not shown). Using this mouse, a reference line LN1 along the standard scale 50 can be input on the visible image IM1 displayed on the first display section 151 of the image display unit 15. The length of the reference line LN1 can be from the "0" position on the scale of the standard scale 50 to any desired scale position, but it is preferable that the length is shorter than the entire length of the standard scale 50, i.e., the maximum measurement length. The length of the reference line LN1 at this time can also be input as a numerical value.

In addition, similar to inputting the reference line LN1, the mouse can be used to input the desired measurement line LN2 on the fluorescence image IM2 displayed on the second display unit 152 of the image display unit 15. In other words, in this embodiment, the measurement line LN2 can be input at a location corresponding to the width of the stomach.

In this way, in the imaging device 1, a reference line LN1 along the standard scale 50 can be input on the visible image IM1 displayed on the image display unit 15, and a desired measurement line LN2 can be input on the fluorescent image IM2 displayed on the image display unit 15. This completes the line input process.

In this embodiment, the scale 50 is photographed by the first photographing unit 171 and is shown in the visible image IM1, but this is not limited to this. For example, if the scale markings of the scale 50 are coated with a fluorescent material, the scale 50 may be photographed by the second photographing unit 172 and shown in the fluorescent image IM2.

4, the imaging device 1 includes a distance calculation unit 60. The distance calculation unit 60 calculates (calculates) the length of the measurement line LN2 based on the length of the reference line LN1. The distance calculation unit 60 is configured with, for example, a CPU.
The calculation method is not particularly limited, and examples thereof include the following methods.
First, the number of pixels in the length of the reference line LN1 (hereinafter referred to as the "first pixel number") and the number of pixels in the length of the measurement line LN2 (hereinafter referred to as the "second pixel number") are detected. Next, a calculation is performed to determine how many times the second pixel number is larger than the first pixel number. Next, the result of this calculation is multiplied by the actual length of the reference line LN1. This gives the actual length of the measurement line LN2.

For example, if the first pixel count is 100 pixels and the second pixel count is 150 pixels, the second pixel count will be 1.5 times the first pixel count. If the actual length of the reference line LN1 is 50 mm, then 50 mm x 1.5 is calculated, and the actual length of the measurement line LN2 is calculated as 75 mm.

In this way, in the imaging device 1, the length of the measurement line LN2 can be calculated based on the length of the reference line LN1. In this way, the length calculation process is performed.
The distance calculation unit 60 can also calculate the length of the measurement line LN2 based on the length of the standard scale 50, without using the length of the reference line LN1. The calculation method in this case is the same as the calculation method described above.

Then, the length of the measurement line LN2 is displayed on the third display section 153 of the image display section 15 as a numerical value NV indicating the actual length. This performs a length display process in which the length of the measurement line LN2 calculated by the distance calculation section 60 is displayed on the third display section 153 of the image display section 15.

The doctor can accurately grasp the width of the stomach, which is the measurement object MO, by visually checking the numerical value NV displayed on the third display unit 153. This allows the surgery to be performed safely and accurately.
As described above, when there is a measurement object MO whose size is to be grasped, the imaging device 1 can be used to accurately grasp the size of the measurement object MO.

The imaging device and imaging method of the present invention have been described above in the illustrated embodiment, but the present invention is not limited to this. Furthermore, each part constituting the imaging device can be replaced with any other configuration that can perform the same function. Furthermore, any other components may be added.

In the above embodiment, indocyanine green is used as the material containing the fluorescent dye, and near-infrared light of about 600 nm to 850 nm is irradiated onto the indocyanine green as excitation light, causing the indocyanine green to emit fluorescence in the near-infrared region with a peak at approximately 810 nm. However, light other than near-infrared light may also be used.

Depending on the case of the subject, instead of using indocyanine green as a fluorescent dye, for example, 5-aminolevulinic acid (5-ALA/5-Aminolevulinic Acid) may be used.

[Aspects]
It will be appreciated by those skilled in the art that the exemplary embodiments described above are examples of the following aspects.

(1) An imaging device (1) according to one aspect includes:
A first light source (241) that irradiates white light toward the subject;
a second light source (242) that irradiates the subject with excitation light for exciting the fluorescent dye injected into the subject;
A scale (50) arranged in close proximity to the subject;
A first imaging unit (171) that captures a visible image by imaging the subject irradiated with the white light;
a second imaging unit (172) that captures a fluorescence image by capturing the fluorescence emitted from the fluorescent dye;
an image display unit (15) for displaying the visible image and the fluorescent image;
a user interface (10) for inputting a desired measurement line on the fluorescence image displayed on the image display unit;
a distance calculation unit (60) that calculates the length of the measurement line based on the length of the standard scale photographed by the first photographing unit or the second photographing unit;
Equipped with
The image display unit is configured to display the length of the measurement line calculated by the distance calculation unit.

When there is a measurement object whose size is to be ascertained, the imaging device described in paragraph 1 makes it possible to accurately ascertain the size of the measurement object.

(2) The imaging device (1) according to (1),
The apparatus further includes a recording unit (20) for recording the visible image and the fluorescent image,
The image display section may be configured to display the visible image and the fluorescent image recorded in the recording section.

The imaging device described in paragraph 2 makes it possible to accurately grasp the size of the measurement object in the recorded visible image and fluorescent image.

(Item 3) An imaging device (1) according to one aspect includes:
A first light source (241) that irradiates white light toward the subject;
a second light source (242) that irradiates the subject with excitation light for exciting the fluorescent dye injected into the subject;
A scale (50) arranged in close proximity to the subject;
A first imaging unit (171) that captures a visible image by imaging the subject irradiated with the white light;
a second imaging unit (172) that captures a fluorescence image by capturing the fluorescence emitted from the fluorescent dye;
an image display unit (15) for displaying the visible image and the fluorescent image;
a user interface (10) for inputting a reference line along the standard scale on the visible image displayed on the image display unit and inputting a desired measurement line on the fluorescent image displayed on the image display unit;
A distance calculation unit (60) that calculates the length of the measurement line based on the length of the reference line;
Equipped with
The image display unit is configured to display the length of the measurement line calculated by the distance calculation unit.

The imaging device described in paragraph 3 makes it possible to accurately determine the size of the measurement target object based on the length of the reference line.

(4) The imaging device (1) according to (3),
The apparatus further includes a recording unit (20) for recording the visible image and the fluorescent image,
The image display section may be configured to display the visible image and the fluorescent image recorded in the recording section.

The imaging device described in paragraph 4 makes it possible to accurately grasp the size of the measurement object in the recorded visible image and fluorescent image.

(Item 5) An imaging method according to one aspect includes:
irradiating a subject with white light;
irradiating the subject with excitation light for exciting the fluorescent dye injected into the subject;
acquiring a visible image by photographing the subject illuminated with the white light;
acquiring a fluorescence image by capturing the fluorescence emitted from the fluorescent dye;
displaying the visible image and the fluorescent image on an image display unit;
inputting a desired measurement line on the fluorescent image displayed on the image display unit;
a step of acquiring the standard scale image in the step of acquiring the visible image or the step of acquiring the fluorescent image, and calculating the length of the measurement line based on the length of the standard scale image;
The method may further include a step of displaying the length of the measurement line calculated by the distance calculation unit on the image display unit.

According to the imaging method described in paragraph 5, when there is a measurement object whose size is to be ascertained, the size of the measurement object can be accurately ascertained.

(Item 6) The imaging method according to item 5,
recording the visible image and the fluorescent image;
The step of displaying on the image display unit can display the visible image and the fluorescent image recorded on the recording unit.

The imaging device described in paragraph 6 makes it possible to accurately grasp the size of the measurement object in the recorded visible image and fluorescent image.

(Item 7) An imaging method according to one aspect includes:
irradiating a subject with white light;
irradiating the subject with excitation light for exciting the fluorescent dye injected into the subject;
acquiring a visible image by photographing the subject illuminated with the white light;
acquiring a fluorescence image by capturing the fluorescence emitted from the fluorescent dye;
displaying the visible image and the fluorescent image on an image display unit;
inputting a reference line along the standard scale on the visible image displayed on the image display unit, and inputting a desired measurement line on the fluorescent image displayed on the image display unit;
a step of acquiring the reference scale image in the step of acquiring the visible image or the step of acquiring the fluorescent image, and calculating the length of the measurement line based on the length of the reference line;
The method may further include a step of displaying the length of the measurement line calculated by the distance calculation unit on the image display unit.

The imaging device described in paragraph 7 makes it possible to accurately determine the size of the measurement target object based on the length of the reference line.

(Item 8) The imaging method according to item 7,
recording the visible image and the fluorescent image;
The step of displaying on the image display unit can display the visible image and the fluorescent image recorded on the recording unit.

The imaging device described in paragraph 8 makes it possible to accurately grasp the size of the measurement object in the recorded visible image and fluorescent image.

LIST OF SYMBOLS 1 Imaging device 10 Operation unit 11 Cart 12 Illumination/photography unit 13 Wheels 14 Handle 15 Image display unit 151 First display unit 152 Second display unit 153 Third display unit 16 Recess 17 Image forming unit 171 First photography unit 172 Second photography unit 18 Image synthesis unit 19 Storage unit 20 Recording unit 24 Light source unit 241 First light source 242 Second light source 25 Light source control unit 26 Zoom lens 27 Prism 28 White light sensor 29 Excitation light sensor 30 Arm mechanism 31 First arm member 32 Second arm member 33 Hinge unit 34 Hinge unit 35 Hinge unit 36 Support 37 Support unit 41 Sub-arm 42 Rotation axis 43 Support unit 50 Standard scale 60 Distance calculation unit IM1 Visible image IM2 Fluorescence image IM3 Composite image LN1 Reference line LN2 Measurement line MO Measurement object NV Numeric value ST Subject

Claims (8)

a first light source that emits white light from outside the subject toward the subject;
a second light source that emits, toward the subject, excitation light for exciting the fluorescent dye injected into the subject;
a first imaging unit that captures an image of the subject irradiated with the white light to obtain a visible image;
a second image capturing unit configured to capture a fluorescence image by capturing the fluorescence emitted from the fluorescent dye;
an image display unit that displays the visible image and the fluorescent image;
a user interface for inputting a desired measurement line on the fluorescent image displayed on the image display unit;
a distance calculation unit that calculates the length of the measurement line based on a length of a standard scale that is placed adjacent to the subject and does not contain a fluorescent material and is photographed by the first photographing unit,
An imaging device in which the image display unit displays the length of the measurement line calculated by the distance calculation unit. a recording unit that records the visible image and the fluorescent image,
The imaging apparatus according to claim 1 , wherein the image display unit displays the visible image and the fluorescent image recorded in the recording unit. a first light source that emits white light from outside the subject toward the subject;
a second light source that emits, toward the subject, excitation light for exciting the fluorescent dye injected into the subject;
a first imaging unit that captures an image of the subject irradiated with the white light to obtain a visible image;
a second image capturing unit configured to capture a fluorescence image by capturing the fluorescence emitted from the fluorescent dye;
an image display unit that displays the visible image and the fluorescent image;
a user interface for inputting a reference line along a standard scale that is disposed adjacent to the subject and does not contain a fluorescent material on the visible image displayed on the image display unit, and for inputting a desired measurement line on the fluorescent image displayed on the image display unit;
a distance calculation unit that calculates a length of the measurement line based on a length of the reference line,
An imaging device in which the image display unit displays the length of the measurement line calculated by the distance calculation unit. a recording unit that records the visible image and the fluorescent image,
The imaging apparatus according to claim 3 , wherein the image display unit displays the visible image and the fluorescent image recorded in the recording unit. A step in which a first light source emits white light from outside the subject toward the subject;
a step of emitting excitation light toward the subject from a second light source for exciting a fluorescent dye injected into the subject;
a step of acquiring a visible image by a first imaging unit imaging the subject irradiated with the white light;
a step of acquiring a fluorescence image by a second image capturing unit capturing the fluorescence emitted from the fluorescent dye;
an image display unit displaying the visible image and the fluorescent image;
a step of inputting a desired measurement line on the fluorescence image displayed on the image display unit by a user interface;
a step of calculating the length of the measurement line based on a length of a standard scale that is placed close to the object and does not contain a fluorescent material and is photographed in the step of acquiring the visible image, the distance calculation unit;
and a step of causing the image display unit to display the length of the measurement line calculated by the distance calculation unit. The method further includes a step of recording the visible image and the fluorescent image by a recording unit,
6. The method for operating an imaging apparatus according to claim 5, wherein the image display unit displays the visible image and the fluorescent image recorded in the recording unit. A step in which a first light source emits white light from outside the subject toward the subject;
a step of emitting excitation light toward the subject from a second light source for exciting a fluorescent dye injected into the subject;
a step of acquiring a visible image by a first imaging unit imaging the subject irradiated with the white light;
a step of acquiring a fluorescence image by a second image capturing unit capturing the fluorescence emitted from the fluorescent dye;
an image display unit displaying the visible image and the fluorescent image;
a step of inputting a reference line along a standard scale that is arranged adjacent to the subject and does not contain a fluorescent material, on the visible image displayed on the image display unit by a user interface, and inputting a desired measurement line on the fluorescent image displayed on the image display unit;
a step of calculating the length of the measurement line based on the length of the reference line captured by the distance calculation unit in the step of acquiring the visible image of the reference scale;
and a step of causing the image display unit to display the length of the measurement line calculated by the distance calculation unit. The method further includes a step of recording the visible image and the fluorescent image by a recording unit,
8. The method for operating an imaging apparatus according to claim 7, wherein the image display unit displays the visible image and the fluorescent image recorded in the recording unit.

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