JP7603938B2 - Multi-component liquid composition preparation kit manufacturing tool - Google Patents

Description

The present invention relates to a tool used in manufacturing a kit for preparing a multi-component liquid composition such as a dental adhesive.

Composite resins and composite resin-type resin cement dental materials (hereafter sometimes abbreviated as "CR, etc.") that are commonly used in dental treatment have almost no adhesiveness to tooth structure by themselves. For this reason, when performing treatment (tooth restoration), in order to firmly bond the hardened material such as CR to the tooth structure, it is necessary to apply a dental adhesive (also called a bonding material) to the tooth surface using an applicator before filling or pressing with CR, etc.

Dental adhesives generally contain polymerizable monomers, including polymerizable monomers having an acidic group, and a polymerization initiator for polymerizing and curing the polymerizable monomers. As the polymerization initiator, a chemical polymerization initiator that functions without the need for light irradiation or heating may be used. The chemical polymerization initiator contains a combination of multiple components, such as a reducing agent and an oxidizing agent, that can react immediately upon contact, and therefore must be stored in two or more separate portions. For this reason, dental adhesives using chemical polymerization initiators are generally stored as multiple liquid compositions, with the polymerizable monomer components appropriately divided in accordance with the division of the chemical polymerization initiator components, and the dental adhesive is prepared by mixing these divided liquid compositions when used. In addition, kits (in the present invention, a kit refers to a product in which two or more agents are combined into one product for the purpose of reducing the burden during preparation and preventing contamination and foreign matter from entering) and jigs for facilitating such storage, preparation, and application (using an applicator) are also known.

For example, Patent Document 1 describes such a kit as a kit for preparing a multi-component liquid composition, which is "a kit for storing components of a multi-component liquid composition that exhibits a predetermined function by dividing them into two or more liquids and mixing the divided liquids at the time of use to prepare the multi-component liquid composition, the kit including a composite liquid package having a plurality of liquid storage sections and a connecting section, in which all of the plurality of liquid storage sections are connected to each other at the connecting sections to form an integrated body, and an outer bag that fixes the composite liquid package therein and airtightly houses the composite liquid package, the outer bag having a liquid storage space that can hold all of the liquid that flows out when a pressing force is applied to the liquid held in the liquid storage section of the composite liquid package fixed and housed therein, causing the liquid to flow out from one end of the liquid storage section, without causing the liquid to come into contact with the composite liquid package."

As shown in FIG. 1, this multi-component liquid composition preparation kit can be used as follows if the weakened line 44 is formed. That is, first, the outer bag 3 is pressed by pinching the front and back walls of the outer bag 3 with two fingers to allow the liquid to flow out of the composite liquid package into the liquid storage space, and then the outer bag 3 is broken along the weakened line 44 from the notch 46 and the upper part is removed to form an applicator insertion opening 48. Then, the outer bag 3 is held with one hand and the applicator 50 is held with the other hand, and the applicator 50 is inserted into the outer bag 3 through the applicator insertion opening 48 to deposit the liquid stored in the liquid holding portion 54, and then the dental adhesive composition can be applied to the desired area of the patient's treated tooth by pulling it out.

In addition, Patent Document 1 describes a method for producing a kit for preparing the above-mentioned multi-component liquid composition, which includes: "a strip-shaped substrate made of a heat-sealable laminate film or heat-sealable laminate sheet, which includes at least an inner layer made of a sealant material and an outer layer made of an exterior material, is arranged so that the inner layer is on the upper surface, and a plurality of strips are arranged on the upper surface at a predetermined interval in the longitudinal direction of the strip-shaped substrate at the center or approximately center in the width direction of the strip-shaped substrate so that the other end of the bag body in the liquid agent storage section of the composite liquid agent package is perpendicular to the longitudinal direction of the strip-shaped substrate; and a temporary fixing step in which the composite liquid agent package obtained in the temporary fixing step is heat-sealed so that both side end regions of the strip-shaped substrate, which have been temporarily fixed at a predetermined interval, are parallel to the longitudinal direction. and a bag forming step of heat-sealing and joining the adjacent temporarily-attached composite liquid package bodies of the cylindrical body obtained in the cylindrical forming step in a direction perpendicular to the longitudinal direction to join the portions between the adjacent temporarily-attached composite liquid package bodies, and cutting the central or nearly central portion of the joined portion in a direction perpendicular to the longitudinal direction to obtain a pillow flat bag containing one of the composite liquid package bodies; and the method is characterized in that, during the heat sealing in the bag forming step, the integrated fusion sealant material at the joint portion of the temporarily-attached composite liquid package body is fused to the sealant material constituting the inner layer of the strip-shaped substrate.

International Publication No. 2020/158238

The method described in Reference 1 is a continuous process in which the outer pouch and the multi-component liquid composition preparation kit are produced simultaneously, allowing for efficient mass production. However, since it is not a batch process, it is difficult to accommodate minor changes in specifications, and efficiency can actually decrease when the loss (of time, energy, materials, etc.) required for stabilization at the start of the process and the operating rate of the equipment are taken into consideration. Therefore, the present invention aims to provide a method for producing a multi-component liquid composition preparation kit by a batch process or semi-batch process.

The present invention solves the above-mentioned problems , and comprises two or more liquid agent packages and an outer bag consisting of a flat bag having one end and the other end and having a rectangular shape with two main surfaces, the front and back of which are substantially identical in shape, wherein the two or more liquid agent packages contain components of a multi-component liquid composition exhibiting a predetermined function, packaged into two or more liquid agents, inside two or more bags of substantially the same shape, each having one end and the other end, and are configured so that the liquid agents flow out from one end by applying a pressing force to the liquid agents held inside each bag, and the internal space of the outer bag is located near the other end. a liquid agent package accommodating space located in the outer bag and a liquid reservoir space located near one end, the two or more liquid agent packages being fixed and airtightly accommodated within the liquid agent package accommodating space of the outer bag, and a liquid agent that flows out from one end of the bag by applying a pressing force to the liquid agent held inside the two or more bags of the two or more liquid agent packages by pressing the outer bag, the liquid agent that flows out can be held in the liquid reservoir space without coming into contact with the two or more bags,
a member preparation step of preparing a material member for the outer bag, the outer bag being in an open state with the other end portions of the two main surfaces, front and back, of the outer bag not being joined, and the two or more liquid agent packages;
a member arranging step of holding the open outer bag and the two or more liquid agent packages in a "set and held state" in which the two or more liquid agent packages are arranged and held at predetermined positions in an area that will be the liquid agent package storage space within the opening of the open outer bag, which is held by widening the opening of the other end so that the two or more liquid agent packages can be inserted; and a sealing and integration step of sealing by closing and joining the other parts of the two main surfaces (front and back) that form the opening of the open outer bag held in the set and held state in the member arranging step, and fixing and airtightly storing the two or more liquid agent packages within the liquid agent package storage space of the outer bag;
The present invention relates to a jig that can be used in the component arrangement step of a method for producing a multi-component liquid composition preparation kit (hereinafter also referred to as the "production method of the present invention"), comprising:

More specifically , each of the two or more bags in the two or more liquid agent packages is made of a heat-sealable laminate film or a heat-sealable laminate sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material, and has one end and the other end which are sealed portions formed by heat-sealing the ends of the heat-sealable laminate film or the heat-sealable laminate sheet,
The multi-component liquid composition preparation kit is a manufacturing object, and the outer bag is a pillow flat bag made of a heat-sealable laminated film or a heat-sealable laminated sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material, and has one end sealed part, the other end sealed part and the outer bag back sealed part formed by heat sealing at one end, the other end and the back, respectively;
the arrangement positions of the two or more liquid agent packages in the set completion and holding state of the member arrangement step are positions where, when the opening of the open outer bag is closed, other end portions of all of the two or more liquid agent packages are sandwiched between other end portions of the open outer bag facing each other,
The present invention relates to a jig used in the manufacturing method of the present invention (hereinafter also referred to as the "preferred manufacturing method of the present invention"), in which the other end of the open outer bag is heat-sealed in the sealing and integration step, thereby simultaneously joining and sealing the other end and fixing the two or more liquid agent packages to the inside of the outer bag .

That is, the present invention provides an embodiment having an "outer bag" and "two or more liquid agent packages" each of which is a flat bag having two main surfaces, front and back, substantially identical rectangular shapes, and one end and the other end, the outer bag being made of a heat-sealable laminate film or heat-sealable laminate sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material, the outer bag being made of a pillow flat bag having one end seal part, the other end seal part and the outer bag back seal part formed by heat sealing at one end, the other end and the back, respectively, the two or more liquid agent packages being fixed and airtightly contained in a liquid agent package containing space, which is an internal space located near the other end of the outer bag. a "multi-component liquid composition preparation kit" for use in manufacturing the "multi-component liquid composition preparation kit" by holding the open outer bag and the two or more liquid agent packages in a "set and held state" in which the two or more liquid agent packages are arranged and held at predetermined positions in an area of an "open outer bag" that is a material component of the outer bag and in which the other end of the outer bag is unjoined and open, and then heat-sealing the other end of the open outer bag to simultaneously join and seal the other end and fix the two or more liquid agent packages to the inside of the outer bag, the jig comprising:
The jig body is made of a block body having a bottom surface made of a flat surface and a top surface made of a flat surface arranged parallel to the bottom surface, and a bottomed groove having an opening on the top surface is formed therein.
the bottomed groove is formed so that the open outer bag can be inserted and removed freely, and has a structure for holding the open outer bag and the two or more liquid agent packages in the set-completed holding state when one end edge of the open outer bag is inserted into the bottomed groove so as to abut against the groove bottom; the bottomed groove has a "wide portion" and a "narrow portion" formed so as to communicate with the wide portion in both length directions and downward of the wide portion;
A direction along the edge of one end of the outer bag is defined as a length direction, a direction perpendicular to the length direction and from the edge of the one end toward the other end is defined as a height direction, and a direction perpendicular to the length direction and the height direction is defined as a thickness direction,
The length (mm) of one end edge of the open outer bag is L1 _, and the length (mm) of one end edge of each bag of the two or more liquid agent packages is _L2 ,
Regarding the heights (mm) from the bottom of the groove and the edge of one end of the open outer bag, the height (mm) of the edge of the other end of the open outer bag is defined as H1 _, the height (mm) of the position that becomes the edge of one end of the region that becomes the other end seal portion when the outer bag is formed is defined as H2 _, and the height (mm) of the lowest edge of one end of the bag body in the two or more liquid agent packages is defined as _H3 .
The thickness (mm) of each of the two or more liquid drug packages: Wmin is the thinnest thickness (mm) _, and _Wall is the total thickness (mm) ,
When the minimum width, maximum width, depth and length of the wide portion are respectively minimum width: w11 _, maximum width: w12 _, depth: _d1 and length: l1 _, and the minimum width, maximum width, depth and length of the narrow portion are respectively minimum width: w21 _, maximum width: w22 _, depth: d2 _and length: _l2 ,
The wide portion and the narrow portion are each selected from the following (1) to (7).
(1) (thickness of one end of the outer bag with opening) < w ₁₁ = (or ≒) w ₂₂ < W _min
(2) (thickness of one end of the outer bag with opening) < w ₂₁
(3) W _all < w ₁₂
(4) (H ₂ - H ₃ )×0.1≦d ₁ <(H ₂ - H ₃ )
(5) _d1 < _d2
(6) (d ₂ - d ₁ ) = (or ≒) H ₃
(7) L ₂ < l ₂ < L ₁ < l ₁
Satisfy all the relationships shown in
The present invention relates to a tool for manufacturing a multi-component liquid composition preparation kit.

In the above-described form of a manufacturing jig for a multi-component liquid composition preparation kit (hereinafter also referred to as the "jig of the present invention"), in the "set completion holding state" of the component arrangement step in the preferred manufacturing method of the present invention, it is preferable that the two or more liquid agent packages are held in a position where, when the opening of the open outer bag is closed, the other ends of all of the two or more liquid agent packages are sandwiched between the opposing other ends of the open outer bag, and that the narrow width portion and/or the wide width portion are provided with a rear seal portion relief notch for preventing the maximum opening width of the open outer bag from being narrowed by the outer bag rear seal portion near the other end of the open outer bag abutting against the inner surface of the upper region of the bottomed groove in the set completion holding state.

Furthermore, in these preferred embodiments of the jig of the present invention, it is even more preferable that it has at least one of the following characteristics (1) to (3).

(1) The jig body has a basic shape consisting of a rectangular parallelepiped with a top surface and a bottom surface that are rectangular, and multiple bottomed grooves are arranged in a row at predetermined intervals along the longitudinal direction of the top surface.

(2) Each of the multiple bottomed grooves arranged in a row at a predetermined interval along the longitudinal direction of the top surface of the jig body is arranged in a row so that the longitudinal direction of each bottomed groove is inclined at a certain angle within 1 to 3 degrees with respect to the longitudinal direction of the top surface .

(3) At least one of the longitudinal side surfaces of the jig body is provided with laser marking openings having a predetermined opening area which correspond to a plurality of bottomed grooves arranged in a row at predetermined intervals along the longitudinal direction of the upper surface of the jig body and communicate with each of the narrow width portions.

The manufacturing method of the present invention makes it possible to efficiently manufacture a bonding material preparation kit in a batch or semi-batch process using pre-prepared open outer bags and bags that hold individual portions of the liquid agent as raw materials. Furthermore, by using the tool of the present invention, the method of the present invention can be carried out more efficiently and reliably.

This figure is a schematic diagram showing the kit disclosed in Patent Document 1, which is also the present kit, and how to use the kit, and corresponds to Figures 6 and 10 of Patent Document 1. The figure shows (A) a perspective view and (B) a cross-sectional view taken along the line XX' of a multi-component liquid composition preparation kit (the present kit) suitable as the target product of the production method of the present invention. The figures show (A) a front view, (B) a top view, and (C) a right side view of a representative jig of the present invention. This figure shows (a) a YY' cross-sectional view before an open outer bag is inserted into the jig of the present invention shown in Figure 3, and (b) a YY' cross-sectional view when two or more liquid agent packages have been arranged after the open outer bag has been inserted and the jig is in a set and held state.

The following provides a detailed explanation of the multi-component liquid composition preparation kit (hereinafter also referred to as "the kit"), which is the subject of the use of the auxiliary device of the present invention, the manufacturing method of the present invention, and the tool of the present invention, with reference to the drawings.

In this specification, unless otherwise specified, the notation "x~y" using the numerical values x and y means "greater than or equal to x and less than or equal to y." In such notations, when a unit is added only to the numerical value y, the unit is also applied to the numerical value x. In addition, in this specification, the term "(meth)acrylate" means both "acrylate" and "methacrylate," and the term "(meth)acryloyl" means both "acryloyl" and "methacryloyl."

1. The Present Kit The multi-component liquid composition preparation kit (the present kit), which is the production target of the present invention, is not particularly different from the kit disclosed in Patent Document 1, shown in Figure 1. Hereinafter, the present kit 10 will be described with reference to Figures 1 and 2.

As shown in FIG. 2, the kit 10 includes two or more liquid agent packages 20; and an outer bag 30 consisting of a flat bag 33 having one end 31 and the other end 32 and having substantially the same rectangular shape with two main surfaces 34a, b on the front and back. The two or more liquid agent packages 20 are two or more bags 20 (in the figure, they are shown as packaging materials for the liquid agent packages, so they are represented by the same numbers here) having substantially the same shape with one end 21 and the other end 22, and the liquid agent 23 is enclosed and held inside. The liquid agent 23 is enclosed in such a way that the liquid agent 23 flows out from the one end 21 by applying a pressing force to the liquid agent 23 held inside each bag. The outer bag 30 has a liquid agent package storage space (bag storage space) 36 and a liquid pool space 37 inside, and the two or more bags 20 are fixed and hermetically stored in the bag storage space 36.

Regarding the liquid agent 23 packaged in the two or more liquid agent packages (bags) 20, each liquid agent 23 held inside each bag is a multi-component liquid composition having a predetermined function, divided into two or more (specifically, the number of bags), and the multi-component liquid composition can be prepared by flowing all of the liquid agents 23 held in the two or more bags into the liquid storage space 37 and mixing them. The liquid storage space 37 is a space that can hold the (all) liquid agent 23 that flows out without contacting the two or more bags 20 when a pressing force is applied to the liquid agent 23 held inside the two or more bags 20 contained in the bag storage space 36 by pressing the outer bag 30 to cause the liquid agent 23 to flow out of (all) the bags 20. The (all) liquid agent 23 that flows out is stored in the liquid storage space 37, so that it is possible to prepare the multi-component liquid composition and perform the application operation described below without being hindered by the bags 20.

In the present kit 10 shown in FIG. 2, the two main surfaces 34 of the outer bag 30, that is, the one main surface 34a and the other main surface 34b facing each other, are defined with pressurized areas 35a, b at predetermined positions corresponding to each other. The pressurized areas 35 (a, b) are areas determined based on the shape and size of the two or more bags 20 (flat bags 24) and the amount of liquid 23 held therein, as well as the position of the bag storage space 36 (or the fixed position of the two or more bags 20), and are defined as areas where the liquid 23 can be reliably and efficiently flowed out of one end (one end) 21 of the bag 20 by pressing the areas on the outer bag 30. Therefore, the pressurized areas 35 (a, b) are defined at substantially the same positions on the front and back main surfaces 34 of the outer bag 30 (i.e., the one main surface 34a and the other main surface side 34b). In FIG. 2(A), the area printed with "Push here" corresponds to the pressed area 35.

In the present kit 10 shown in FIG. 2, each of the bags 20 of the two or more liquid agent packages is a flat bag 24 having a substantially identical rectangular shape, and the two or more bags 20 (flat bags 24) are arranged so that the liquid agent 23 flows out from one end 21 of all the bags 20 (flat bags 24) by pressing the pressed areas 35a, b of the outer bag 30, with the one end 21 and the other end 22 facing the one end 31 side and the other end 32 side of the outer bag 30, respectively, and the other end 22 of all the bags 20 (flat bags 24) is overlapped and sandwiched between the other end 32a on the one main surface 34a side and the other end 32b on the other main surface side 34b, and fixed and airtightly contained in the bag storage space 36.

The sizes of the bag 20 and the outer bag 30 may be appropriately determined depending on the amount of the liquid agent 23 to be held, but when the multi-component liquid composition is a dental adhesive, the amount of the liquid agent 23 held in each bag 20 is usually about 0.03 to 0.1 ml because the multi-component liquid composition is disposable, and the size of the bag 20 (flat bag 24) is about 16 to 40 mm in length and about 5 to 15 mm in width. The size of the outer bag 30 is about 28 to 72 mm in length and about 12 to 36 mm in width, and the area of the pressed region 35 is about 240 to 400 ^mm2 .

The width _L1 of the flat bag 33 constituting the outer bag 30 is longer than the width _L2 of the bag body 20 (flat bag 24) by a predetermined length, and by moving the two or more bag bodies 20 toward one side end 31 toward the inside of the outer bag and fixing them, an applicator insertion space 38 adjacent to the bag body accommodating space 36 is provided on the other end side of the liquid pooling space 37 of the outer bag 30. A weakened line WL is formed on one main surface 34a and the other main surface 34b of the outer bag 30 to form an applicator insertion opening (not shown) by cutting out and removing a removal portion 39 consisting of a part of the other end side of the area covering the applicator insertion space 38.

Explaining the relationship between the present kit 10 shown in Fig. 2 and the kit shown in Fig. 1 (disclosed in Patent Document 1), in Fig. 2, the fixed positions of two or more liquid agent packages (bags) 20 are set at the bag storage space 36 at approximately the center of the outer bag 30, and when viewed from the other main surface 34b side, they correspond to the multi-component liquid composition preparation kit 1 shown in Fig. 1. That is, each package, its one end, the other end, and the liquid agent in the composite liquid agent package 2 in Fig. 1 respectively correspond to the bag 20 (flat bag 24), one end, the other end, and the liquid agent 23 in the present kit 10, and the composite liquid agent package 2 corresponds to the other end 22 of all the bags 20 in the present kit 10 stacked and integrated. Additionally, the outer bag 3, bottom seal portion (one end) 40, top seal portion (other end) 42, and weakened line 44 in FIG. 1 correspond to the outer bag 30 (flat bag 33), one end 31, the other end 32, and weakened line WL in the kit 10 in FIG. 2, respectively.

A typical example of the multi-component liquid composition is a so-called two-liquid mixed dental adhesive that contains polymerizable monomers including an acidic group-containing polymerizable monomer and a polymerizable monomer that does not have an acidic group, a chemical polymerization initiator, and a water-soluble organic solvent and/or water as the main components. Here, the following are suitable components that can be used in the two-liquid mixed dental adhesive.

That is, examples of the acidic group-containing polymerizable monomer include 2-(meth)acryloyloxyethyl dihydrogen phosphate, 10-(meth)acryloyloxydecyl dihydrogen phosphate, di[2-(meth)acryloyloxyethyl]hydrogen phosphate, di[10-(meth)acryloyloxydecyl]hydrogen phosphate, 4-(meth)acryloxyethyl trimellitic acid, 11-(meth)acryloyloxy-1,1-undecanedicarboxylic acid, 1,4-di(meth)acryloyloxypyrrolidone, 1,2-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,3-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,4-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,5-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,6-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,7-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,8-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,9-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,1-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,2-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,3-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,4-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,5-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,6-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,7-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,8-di(meth)acryloyloxyethyl dihydrogen phosphate, 1,9-di(meth)acryloyloxyethyl dihydrogen phosphate, Compounds that have at least one acidic group, such as a phosphoric acid group, a carboxy group, a sulfonic acid group, or a phosphonic acid group, and at least one polymerizable unsaturated group in one molecule, such as mellitic acid, 2-(meth)acryloyloxyethyl maleic acid, 2-(meth)acryloyloxyethyl phthalic acid, 2-(meth)acryloyloxyethyl hexahydrophthalic acid, 2-methacrylamide-2-methylpropanesulfonic acid, 2-acrylamide-2-methylpropanesulfonic acid, p-vinylbenzenesulfonic acid, and vinylsulfonic acid, can be preferably used.

Examples of polymerizable monomers that do not have an acidic group include 2-hydroxyethyl (meth)acrylate, 2-hydroxypropyl (meth)acrylate, glycerol di(meth)acrylate, 2,2'-bis{4-[3-(meth)acryloyloxy-2-hydroxypropoxy]phenyl}propane, 2,2'-bis[4-(meth)acryloyloxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxypolyethoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxydiethoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxytetraeth ... Bis[4-(meth)acryloyloxypentaethoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxydipropoxyphenyl]propane, 2,2'-bis[4-(meth)acryloyloxyethoxyethoxyphenyl]propane, 2-[4-(meth)acryloyloxydiethoxyphenyl]-2-[4-(meth)acryloyloxytriethoxyphenyl]propane, 2-[4-(meth)acryloyloxydipropoxyphenyl]-2-[4-(meth)acryloyloxytriethoxyphenyl]propane, 2,2-bis[4-(meth)acryloyloxypropoxyphenyl]propane, etc. can be preferably used.

Suitable water-soluble organic solvents include acetone, methanol, ethanol, n-propanol, isopropyl alcohol, and methyl ethyl ketone.

As the chemical polymerization initiator, an appropriate combination of an oxidizing agent, a reducing agent, and a polymerization accelerator can be suitably used. As the oxidizing agent, organic peroxides such as benzoyl peroxide, parachlorobenzoyl peroxide, 2,4-dichlorobenzoyl peroxide, acetyl peroxide, lauroyl peroxide, tertiary butyl peroxide, cumene hydroperoxide, 2,5-dimethylhexane, 2,5-dihydroperoxide, methyl ethyl ketone peroxide, and tertiary butyl peroxybenzoate, and azo compounds such as azobisisobutyronitrile, methyl azobisisobutyrate, and azobiscyanovaleric acid can be suitably used. As reducing agents, amine compounds such as N,N'-dimethyl-p-toluidine, N,N'-dimethylaniline, N'-β-hydroxyethyl-aniline, N,N'-di(β-hydroxyethyl)-aniline, N,N'-di(β-hydroxyethyl)-p-toluidine, N-methyl-aniline, and N-methyl-p-toluidine can be preferably used. As polymerization accelerators, vanadium compounds, copper compounds, sulfinates, borate compounds, thiourea compounds, and the like can be preferably used. Note that all chemical polymerization initiator systems are designed to function as initiators when all components are present, and the combination of each component when packaging is appropriately determined in consideration of storage stability according to the type of liquid and the specific compounds used. For example, borate, which is classified as a polymerization accelerator in the above, functions as a reducing agent under certain conditions, but can also be stored in the presence of an oxidizing agent in the absence of an acidic compound (unless the conditions are acidic).

From the standpoint of manufacturing efficiency of the kit 10, it is preferable that the other end portions 22 of all of the two or more bag bodies 20 (flat bags 24) are stacked and integrated in advance to form a composite liquid agent package. The above-mentioned composite liquid agent package can be suitably manufactured by a method including: (I) a step of preparing a plurality of individual packages for liquid agent storage, in which the liquid agent is airtightly and liquidtightly held inside a bag body made of a flat pillow bag having a lower end heat-sealed portion as one end (one end) and an upper end heat-sealed portion as the other end (other end) by vertical pillow packaging using a heat-sealable laminate film or heat-sealable laminate sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material; and (II) a joining step of overlapping all the other ends (other ends) of the plurality of individual packages for liquid agent storage prepared in the step of preparing the individual packages for liquid agent storage, and heating and pressurizing the overlapping region where all the other ends are overlapped, thereby extruding a portion of the sealant material constituting the inner layer in the overlapping region of each other end outward from the end of the outer layer of each other end, and fusing the extruded extended sealant material to each other.

The inner layer of the heat-sealable laminate film (or heat-sealable laminate sheet) is composed of a resin with high heat fusion (heat-sealing properties) that serves as a sealant material, for example, a mixture of a polymer alloy mainly composed of an ionomer of a copolymer of ethylene and methacrylic acid acrylate, and polyethylene, and the inner layer (sealant material layer) usually has a thickness of 10 to 100 μm, preferably 30 to 80 μm. The outer layer 12 is composed of a resin with low heat fusion (no heat-sealing properties), an inorganic material, or a composite of both, and depending on the liquid agent contained inside, a material that imparts functions such as oxygen gas shielding (oxygen gas impermeability) and ultraviolet ray shielding properties, a material that provides transparency that allows the presence of the contents to be confirmed, and a material that enhances the printability on the outer surface are appropriately selected for the purpose of improving the storage stability, etc., depending on the liquid agent contained inside. In addition, an intermediate layer can be provided between the inner layer and the outer layer to further enhance functionality.

The outer bag 30 is also a pillow flat bag made of a heat-sealable laminate film (or a heat-sealable laminate sheet) including at least an inner layer made of a sealant material and an outer layer made of an exterior material, and is made into a bag body by heat-welding (heat sealing) both side edges of the rectangular heat-sealable laminate film (or heat-sealable laminate sheet) to each other to form a back seal part to form a cylindrical shape, and heat-welding (heat sealing) one end (one end edge) and the other end (the other end edge) to each other. The heat-sealable laminate film (or heat-sealable laminate sheet) basically has the same structure as the heat-sealable laminate film that constitutes the bag body 20, and the same heat-sealing material is used as the heat-sealing material in the heat-sealable laminate film. However, since it is preferable that the outer bag 30 has transparency overall so that the position of the liquid agent that has flowed out due to pressure can be easily confirmed, it is preferable to use a film or sheet of an olefin polymer such as polyethylene, polypropylene, polybutylene, or a copolymer obtained by copolymerizing at least two or more types of olefin monomers selected from ethylene, propylene, butene, etc., as the exterior material that constitutes the outer layer.

In this kit 10, the outer bag 30 is sealed on all four sides. At this time, the space between the outer bag 30 and the two or more bags 20 is usually filled with air (atmosphere). In order to apply a pressing force to the liquid agent held in the two or more bags 20 (flat bags 24) to facilitate the liquid agent flowing out of one end (one end) of each liquid agent storage section, it is preferable to adjust the amount of air filled in the space so that the volume of the space is 1 to 70%, particularly 5 to 40%, of the maximum volume of the space (the volume of the outer bag 30 when it is filled with as much air as possible under atmospheric pressure or under a slight pressure that does not damage the outer bag 30, minus the volume occupied by the two or more bags 20 contained therein).

The outer bag 30, which is a pillow flat bag, may be made by heat-sealing both side edges of the rectangular heat-sealable laminate film (or heat-sealable laminate sheet) to each other to form a back seal, forming a cylindrical shape, heat-sealing the cylindrical body at a predetermined interval along the length direction in a direction perpendicular to the length direction to form a one-end (lower end) seal portion, cutting the one end along a direction perpendicular to the length direction to form an open outer bag 60 with the other end (upper end) open, and then heat-sealing the other end (upper end) of the open outer bag 60 to form the other end (upper end) seal portion to form the outer bag 30.

When using the kit 10 of the present invention, first, the outer bag 30 is pressed, and a pressing force is applied to all of the liquid 23 filled in each of the two or more bags 20, which is then allowed to flow out and mixed in the liquid collection space 37 to prepare the dental adhesive, which is the desired liquid composition. Next, the outer bag 30 is broken from the notch along the weakened line WL, and the removal portion 39 above the weakened line WL of the film or sheet covering the applicator insertion space 38 is removed to open the applicator insertion opening (this operation is also called the "applicator insertion opening formation operation"). From there, as shown in the right diagram of Figure 1, an applicator 50 having a long and thin rod-shaped body 52 and a liquid holding portion 54 arranged at its tip is inserted, and the liquid holding portion 54 is immersed in the dental adhesive and then pulled out to apply the dental adhesive to the required area of the patient's treated tooth, performing the application operation.

2. Manufacturing Method of the Present Invention The manufacturing method of the present invention is a method for manufacturing the present kit, and is characterized by comprising the following member preparation step, member arrangement step, and sealing/fixing step.

Component preparation process: A process for preparing the material components for the outer bag, an open outer bag in which the other end portions of the two main surfaces of the outer bag are open and not joined, and the two or more liquid agent packages.

Component placement process: A process of holding the open outer bag and the two or more liquid agent packages in a "set complete holding state" in which the two or more liquid agent packages are placed and held at predetermined positions in an area that will become the liquid agent package storage space within the opening of the open outer bag, which is held by widening the opening of the other end so that the two or more bags can be inserted.

Sealing and integration process: A process of sealing the other part of the two main surfaces, front and back, that form the opening of the open outer bag held in the set-completed holding state in the member arrangement process by closing and joining them, and fixing the two or more liquid agent packages within the liquid agent package storage space of the outer bag to store them airtight.

In addition, in order to hold the open outer bag and the two or more liquid agent packages in the "set complete holding state" in the above-mentioned component arrangement process, it is preferable to use a dedicated jig.

In the manufacturing method of the present invention, each of the two or more bags in the two or more liquid agent packages is preferably made of a heat-sealable laminate film or a heat-sealable laminate sheet that includes at least an inner layer made of a sealant material and an outer layer made of an exterior material, one end of the heat-sealable laminate film or the heat-sealable laminate sheet is heat-sealed to form one end, and the other end is open. As the two or more liquid agent packages (bags) using such bags, those manufactured by the manufacturing method already described are preferably used.

The open outer bag is a material member that is an intermediate material for a pillow flat bag that is made of a heat-sealable laminated film or heat-sealable laminated sheet that includes at least an inner layer made of a sealant material and an outer layer made of an exterior material, and has one end sealed part, the other end sealed part, and the outer bag back seal part formed by heat sealing at one end, the other end, and the back, respectively, and is in a state in which the other end is open before the one end sealed part and the back seal part are formed and the other end is heat-sealed. As such an open outer bag, it is preferable to use a pillow flat bag that has a back seal part and one end sealed part and is in a state in which the other end (upper end) is open, which is obtained when manufacturing the outer bag 30 made of the pillow flat bag described above, and later the other end (upper end) is heat-sealed to form the other end seal part to form the outer bag 30.

Furthermore, in addition to using two or more liquid agent packages (bags) and an open outer bag made of such a heat-sealable laminate film or heat-sealable laminate sheet, it is preferable that the arrangement positions of the two or more liquid agent packages in the set-completed holding state of the member arrangement step are positions where, when the opening of the open outer bag is closed, the other ends of all of the two or more liquid agent packages are sandwiched between the other ends of the open outer bag that face each other, and that in the sealing and integration step, the other ends of the open outer bag are heat-sealed to simultaneously join and seal the other ends and fix the two or more liquid agent packages to the inside of the outer bag.

In such a preferred method (preferable manufacturing method of the present invention), the holding of the open outer bag and the two or more liquid agent packages in the "set complete holding state" in the member arrangement step can be preferably performed using the jig of the present invention. Therefore, the jig of the present invention and the preferred manufacturing method of the present invention using the same will be described in detail below with reference to the drawings.

3. Jig of the Present Invention The jig of the present invention has a jig body consisting of a block body having a bottom surface consisting of a flat surface and an upper surface consisting of a flat surface arranged parallel to the bottom surface, and in which a bottomed groove having an opening is formed on the upper surface, and the bottomed groove is formed so that the open outer bag can be inserted and removed freely, and is characterized in that when the edge of one end of the open outer bag is inserted into the bottomed groove so as to abut against the groove bottom, the open outer bag and the two or more liquid agent packages can be held in the set complete holding state.

The block body can be suitably made of a resin material such as polyethylene (PE), polypropylene (PP), polyoxymethylene (POM), polybutadiene terephthalate (PBT), acrylonitrile-butadiene-styrene copolymer synthetic resin (ABS resin), polyamide (PA), polymethyl methacrylate (PMMA), or polytetrafluoroethylene (PTFE). The bottomed groove can be formed by cutting, or by molding the block body into several parts (divided so that the final form can be easily assembled) and assembling them.

The jig of the present invention is not particularly limited as long as it has a structure capable of holding the open outer bag and two or more liquid packaging bodies in a set and holding state with the open outer bag inserted in the bottomed groove of the block body, but from the viewpoint of being able to reliably and efficiently hold the open outer bag and two or more liquid packaging bodies in a set and holding state, it is preferable that (1) the bottomed groove has a wide portion and a narrow portion, and (2) the direction, length, height (depth), and thickness (width) of the bottomed groove, which are defined in relation to the shape and size of the open outer bag and two or more liquid packaging bodies to be used, satisfy the following conditions.

First, the directions and lengths that are the prerequisites (standards) for the conditions to be met will be explained. The directions and lengths of the open outer bag and the two or more liquid agent packages that are held in the set-up holding state are specified as follows (see Figures 3 and 4).

[direction]
Length direction: A direction along one end edge of the opening outer bag,
Height direction: A direction perpendicular to the length direction and from the edge of one end toward the other end. Thickness direction: A direction perpendicular to the length direction and height direction.

[Lengths of the opening outer bag and each bag of two or more liquid drug packages, etc.] The lengths, etc. shall be expressed using the following symbols.
_L1 : Length of one end edge of the outer bag (mm)
_L2 : Length of one end edge of each bag of two or more liquid agent packages (mm)
_H1 : Height of the other end edge of the outer bag from the one end edge (mm)
_H2 : Height (mm) from the edge of one end of the position that will be the edge of one end of the region that will become the other end seal portion when made into an outer bag
_H3 : Height (mm) of the lowest edge of one end of the bag from the edge of one end of the opening of the bag in two or more liquid drug packages
W _min : The thinnest thickness (mm) among the thicknesses W of two or more liquid drug packages
_Wall : The total thickness of two or more liquid packaging bodies (mm).

[Lengths of the wide and narrow portions, etc.] The narrow portions refer to the narrow portions of the wide portions that are formed so as to communicate with the wide portions in both longitudinal directions and downward, and the lengths, etc. of the narrow portions are represented by the following symbols. The depth refers to the depth from the top surface.
_l1 : Length of the wide portion (mm) _l2 : Length of the narrow portion (mm)
_d1 : Depth of the wide portion (mm) _d2 : Depth of the narrow portion (mm)
・_w11 : Minimum width of the wide portion (mm) ・_w21 : Minimum width of the narrow portion (mm)
· _w12 : maximum width of the wide portion (mm) · _w22 : maximum width of the narrow portion (mm).

Next, the conditions that the preferred embodiment of the jig must satisfy are explained. The jig satisfies all of the relationships shown in (1) to (7) below.

(1) (thickness of one end of the outer bag with opening) < w ₁₁ = (or ≒) w ₂₂ < W _min
(2) (thickness of one end of the outer bag with opening) < w ₂₁
(3) W _all < w ₁₂
(4) (H ₂ - H ₃ )×0.1≦d ₁ <(H ₂ - H ₃ )
(5) _d1 < _d2
(6) (d ₂ - d ₁ ) = (or ≒) H ₃
(7) L ₂ <l ₂ <L ₁ <l ₁ .

The above-mentioned preferred embodiment of the jig of the present invention will be described below with reference to Figures 3 and 4. The open outer bag 60 (which is the material for the outer bag) shown in Figure 4 has a back seal part and one end seal part, and the other end (top end) is open, which is manufactured by the method described above. The other end (top end) is later heat-sealed to form the other end seal part to form the outer bag 30. Therefore, each part of the open outer bag 60 in Figure 4 is numbered the same as the corresponding part in the outer bag 30.

The jig 100 of the present invention shown in FIG. 3 is an example of a preferred form of the jig of the present invention, which holds multiple sets (four sets in the figure) of open outer bags 60 and two or more liquid agent packages 20 in a set-up holding state at one time, and by simultaneously carrying out the heat sealing of the sealing and integration process while they are held in that state, it is possible to produce several sets (four in the figure) of kits for preparing a multi-component liquid composition.

That is, the jig body 110 of the jig 100 is a block body having a basic shape of a rectangular parallelepiped with a flat bottom surface 111 and a flat top surface 112 arranged parallel to the bottom surface, and multiple bottomed grooves 120 (four in the figure) are arranged in a row at a specified interval along the longitudinal direction of the top surface.

3(C) and 4, the bottomed groove 120 is a slit-like groove with a width _w21 = _w22 ( _w22 may be slightly larger than _w21 ) and a predetermined depth _d2 , with a length _l1 slightly longer than the width _L1 of the flat bag 33 constituting the open outer bag 60, and the wide portion 121 is formed by partially expanding the diameter of the top opening 113 side from the opening to the depth _d1 . That is, the opening shape of the wide portion 121 is (almost) elliptical, and the Y-Y' cross section at the center is funnel-shaped. On the other hand, the portion outside the wide portion 121 (outside both ends of the wide portion 121 in the length direction) remains a slit-like groove, and is integrated with a narrow portion below the wide portion 121 (portion deeper than the depth _d1 ) with a depth (height) of ( _d2 - _d1 ) and a width of _w21 to form the narrow portion 122. Therefore, the cross section of the outer portions of both ends of the wide portion 121 in the length direction is a vertically long (approximately) rectangular shape with a depth (height) of _d2 and a width of _w21 . In this way, the above-mentioned (5) Depth of the wide portion: _d1 < Depth of the narrow portion: _d2 is satisfied.

By satisfying the condition (1) of "(thickness of one end of the open outer bag)< _w11 ," and the conditions (2) and (7) of " _L1 < _l1 ," the open outer bag 60 can be inserted freely in and out (removably) into the bottomed groove 120 with one end 31 of the outer bag facing downward, and when the open outer bag 60 is inserted, the open outer bag 60 can be held upright even with the other end of the open outer bag 60 open to a predetermined width (width). Moreover, by having the bottomed groove 120 have a wide portion 121 and further satisfying the conditions (3), (1) of " _w11 = (or ≒) _w22 < _Wmin ," and (7) of " _L2 < _l2 ," two or more liquid agent packages 20 can be inserted into the open outer bag 60. Furthermore, by satisfying the relationship of "minimum width of the wide portion: w ₁₁ <total thickness of the two or more liquid agent packages: W _min ", the two or more liquid agent packages cannot enter the narrow portion 122, and the position of one end of the two or more liquid agent packages is determined, and by satisfying the condition (6), the liquid agent packages are positioned in the set-completed holding state position as shown in FIG. 4(b). Finally, by satisfying the condition (4), the liquid agent packages can be held (naturally and independently) in the positioned position. Since the heat sealing in the sealing and integration process can be stably performed while the liquid agent packages are set in the jig, the condition (4) preferably satisfies "(H ₂ -H ₃ )×0.2≦d ₁ <(H ₂ -H ₃ )×0.5", and more preferably satisfies "(H ₂ -H ₃ )×0.25≦d ₁ <(H ₂ -H ₃ )×0.4".

In the jig 100 of the present invention shown in FIG. 3, the rear seal part relief notch 123 is provided in the wide portion 121, so that in the set-completed holding state, the outer bag rear seal part near the other end of the open outer bag 60 can be prevented from abutting against the inner surface of the bottomed groove upper region, thereby narrowing the maximum opening width of the open outer bag. In addition, when the outer bag rear seal part is accommodated in the rear seal part relief notch 123, the rear seal can be prevented from interfering (getting in the way) when the heat sealing is performed while the outer bag is set in the jig.

In addition, in the jig 100, the multiple (four) bottomed grooves 120 are arranged in a row so that their length direction is inclined at a certain angle of 1 to 3 degrees relative to the longitudinal direction of the main body upper surface 112. This makes it easier to control the escape of air (inside the open outer bag) when the sealed part is sandwiched when heat sealing is performed using a heat sealing device of a type that sandwiches the sealed part and heat-pressure-bonds (welds) it, such as a heat sealer. For example, when the other end seal part planned area of the open outer bag 60 is sandwiched on a flat surface, the film surface of the wide width part 121 comes into contact first, and is pressed while escaping air to the left and right from that point, and heat welding is performed. In contrast, when there is an angle, the film surface of one end of the narrow width part 122 comes into contact first, and is pressed while escaping air in one direction from that point, and heat welding is performed. This makes it possible to prevent wrinkles from forming on the heat sealed surface and achieve a smooth finish.

Furthermore, the jig 100 has a laser marking opening 130 having a predetermined opening area that corresponds to the plurality of bottomed grooves and communicates with each of the narrow width portions on one of the longitudinal side surfaces of the jig body 110. Through the laser marking opening 130, the lot number (Lot No.), expiration date, etc. can be printed on the surface of the open outer bag 60 (outer bag 30) while it is held in the jig. Unlike a free-standing container such as an eye drop bottle, the multi-component liquid composition preparation kit is in the form of a bag made of a film material, so it is extremely difficult to make it stand on its own. In addition, since the main surfaces 34a and 34b after heat sealing are curved, when printing is performed, it is necessary to fix each of them individually in a specific direction. However, by using the jig 100, it is possible to print reliably and easily at a predetermined position.

The jig of the present invention has been described above with reference to Figures 3 and 4, but these are shown as examples, and the technical scope of the present invention is not limited to this specific embodiment. For example, the jig may be divided into two parts along the center line of the narrow width portion 122 along the longitudinal direction of the jig, and the opening outer bag 60 may be set, and then the two parts may be combined. This reduces interference between the film and the jig when inserting the opening outer bag 60, and improves workability.

4. Preferred manufacturing method of the present invention using the tool of the present invention In the preferred manufacturing method of the present invention using the tool of the present invention, the open outer bag 60 prepared by the method already described and the two or more liquid agent packages 20 are held in a set-up state using the tool of the present invention as described above, and a sealing and integration process is performed in that state. At this time, as shown in FIG. 4(b), when the opening of the open outer bag 60 is closed, all the other ends 22 of the two or more liquid agent packages 20 are held in a position where they are sandwiched between the opposing other ends 42 of the open outer bag 60, so that by heat-sealing the other end 42 of the open outer bag 60, the joining and sealing of the other end 42 and the fixing of the two or more liquid agent packages 20 to the inside of the outer bag can be performed simultaneously. As described above, the heat sealing can be preferably performed using a heat sealing device of the type that sandwiches the sealed body part and heat-pressure bonds (welds) it, such as a heat sealer. After heat sealing, the lot number, expiration date, etc. can be laser printed through the laser printing opening 130, and then the kit can be removed from the jig to obtain a multi-component liquid composition preparation kit with the markings printed in the specified positions.

1: Multi-component liquid composition preparation kit 2: Composite liquid agent package 3: Outer bag 10: This kit (multi-component liquid composition preparation kit)
20: Liquid packaging body (bag body)
21: One end of bag body 21a: Edge of one end of bag body 22: Other end of bag body 23: Liquid agent 24: Flat bag 30: Outer bag 31: One end of outer bag 32: Other end of outer bag 33: Flat bag 34: Main surface 34a: One main surface 34b: Other main surface 35(a, b): Pressurized area 36: Liquid agent packaged body storage space (bag body storage space)
37: Liquid storage space 38: Space for inserting applicator 39: Removable portion 40: One end (lower end) sealing portion (one end or one end)
40a: Edge of one end 42: Sealed portion of the other end (upper end) (other end or other end)
42a: Edge of other end 42b: Edge of one end side of the region planned for the other end seal portion 42c: Width of the other end seal portion 43: Simple seal portion 44: Weakened line 46: Notch 48: Applicator insertion opening 50: Applicator 52: Rod-shaped main body 54: Liquid (liquid agent) holding portion WL: Weakened line 60: Open outer bag 100: Jig (of the present invention) 110: Jig main body 111: Bottom surface 112: Top surface 113 Top surface opening ₁₂₀ : Bottomed groove 121: Wide portion w11: Minimum width of wide portion _w12 : Maximum width of wide portion _d1 : Depth of wide portion 122: Narrow portion _w21 : Minimum width of narrow portion _w22 : Maximum width of narrow portion _d2 : Depth of narrow portion 123: Relief notch for rear seal portion 130: Laser marking opening

Claims (5)

A "multi-component packaging device" comprising an "outer bag" and "two or more liquid agent packages" each having two main surfaces, front and back, substantially identical in shape and rectangular shape, the flat bag having one end and the other end, the outer bag being made of a heat-sealable laminated film or heat-sealable laminated sheet including at least an inner layer made of a sealant material and an outer layer made of an exterior material, the outer bag being made of a pillow flat bag having one end sealed part, the other end sealed part and the outer bag back surface sealed part formed by heat sealing at one end, the other end and the back surface, respectively, and the two or more liquid agent packages being fixed and airtightly contained in a liquid agent package containing space, which is an internal space located near the other end of the outer bag. a "systematic liquid composition preparation kit" which is a material member of the outer bag, the other end of which is unjoined and open, and which holds the open outer bag and the two or more liquid agent packages in a "set and held state" in which the two or more liquid agent packages are arranged and held at predetermined positions in an area that will be the liquid agent package storage space of an "open outer bag," and then heat-seals the other end of the open outer bag to simultaneously join and seal the other end and fix the two or more liquid agent packages inside the outer bag, the jig being used to hold the open outer bag and the two or more liquid agent packages in the set and held state,
The jig body is made of a block body having a bottom surface made of a flat surface and a top surface made of a flat surface arranged parallel to the bottom surface, and a bottomed groove having an opening on the top surface is formed therein.
the bottomed groove is formed so that the open outer bag can be inserted and removed freely, and has a structure for holding the open outer bag and the two or more liquid agent packages in the set-completed holding state when one end edge of the open outer bag is inserted into the bottomed groove so as to abut against the groove bottom; the bottomed groove has a "wide portion" and a "narrow portion" formed so as to communicate with the wide portion in both length directions and downward of the wide portion;
A direction along the edge of one end of the outer bag is defined as a length direction, a direction perpendicular to the length direction and from the edge of the one end toward the other end is defined as a height direction, and a direction perpendicular to the length direction and the height direction is defined as a thickness direction.
The length (mm) of one end edge of the open outer bag is _L1 , and the length (mm) of one end edge of each bag of the two or more liquid agent packages is _L2 ,
Regarding the heights (mm) from the bottom of the groove and the edge of one end of the open outer bag, the height (mm) of the edge of the other end of the open outer bag is defined as _H1 , the height (mm) of the position that becomes the edge of one end of the region that becomes the other end seal portion when the outer bag is formed is defined as _H2 , and the height (mm) of the lowest edge of one end of the bag body in the two or more liquid agent packages is defined as _H3 .
The thickness (mm) of each of the two or more liquid drug packages: _Wmin is the thinnest thickness (mm), and _Wall is the total thickness (mm),
When the minimum width, maximum width, depth and length of the wide portion are respectively minimum width: _w11 , maximum width: _w12 , depth: _d1 and length: _l1 , and the minimum width, maximum width, depth and length of the narrow portion are respectively minimum width: _w21 , maximum width: _w22 , depth: _d2 and length: _l2 ,
The wide portion and the narrow portion are the following (1) to (7):
(1) (thickness of one end of the outer bag with opening) < w ₁₁ = (or ≒) w ₂₂ < W _min
(2) (thickness of one end of the outer bag with opening) < w ₂₁
(3) W _all < w ₁₂
(4) (H ₂ - H ₃ )×0.1≦d ₁ <(H ₂ - H ₃ )
(5) _d1 < _d2
(6) (d ₂ - d ₁ ) = (or ≒) H ₃
(7) L ₂ < l ₂ < L ₁ < l ₁
Satisfy all the relationships shown in
A tool for manufacturing a multi-component liquid composition preparation kit, comprising: in the "set completion holding state", the two or more liquid agent packages are held at a position where, when the opening of the open outer bag is closed, the other end portions of all of the two or more liquid agent packages are sandwiched between the other end portions of the open outer bag facing each other,
2. The multi-component liquid composition preparation kit manufacturing jig of claim 1, wherein the narrow width portion and/or the wide width portion is provided with a rear seal relief notch to prevent the maximum opening width of the open outer bag from being narrowed by the outer bag rear seal portion near the other end of the open outer bag abutting against the inner surface of the upper region of the bottomed groove in the set and held state. The jig for manufacturing a multi-component liquid composition preparation kit according to claim 1 or 2, wherein the jig body has a basic shape consisting of a rectangular parallelepiped with a top surface and a bottom surface that are rectangular, and a plurality of bottomed grooves are arranged in a row at predetermined intervals along the longitudinal direction of the top surface. The jig for manufacturing a multi-component liquid composition preparation kit according to claim 3, wherein each of the multiple bottomed grooves arranged in a row at a predetermined interval along the longitudinal direction of the upper surface of the jig body is arranged in a row such that the length direction of each bottomed groove is inclined at a certain angle within 1 to 3 degrees with respect to the longitudinal direction of the upper surface. A jig for manufacturing a multi-component liquid composition preparation kit as described in claim 3, wherein at least one of the longitudinal side surfaces of the jig body is provided with laser marking openings having a predetermined opening area that correspond to a plurality of bottomed grooves arranged in a row at a predetermined interval along the longitudinal direction of the upper surface of the jig body and communicate with each of the narrow width portions.