JP7618997B2 - Cleaning sheet - Google Patents

Description

The present invention relates to a wiping sheet in which a sheet-like substrate is impregnated with a quaternary ammonium compound having a specific structure, and a hydroxymonocarboxylic acid and its salt. Specifically, the present invention relates to a wiping sheet that suppresses the adsorption of the quaternary ammonium compound to a sheet-like substrate containing cellulose fibers and the evaporation of the impregnating liquid, and has excellent moisturizing properties when used on the skin.

Recently, coronavirus infections have become a social issue, and hand hygiene has become increasingly important in preventing the spread of infection.
Conventionally, lower monohydric alcohols such as ethanol and isopropanol have been used for hand disinfection, and they have the characteristics of being quick-drying, easy to use, inexpensive, and highly effective at disinfecting. On the other hand, patients with alcohol hypersensitivity tend to avoid using them, and since disinfectants containing lower monohydric alcohols have a degreasing effect, they may dry out the skin and cause rough hands, and because they dry quickly, the ethanol component of the formulation may evaporate and reduce its concentration.

On the other hand, non-alcohol hand disinfectants that do not contain lower monohydric alcohols are easy to use even for patients with alcohol hypersensitivity, there is less concern about rough hands, and the amount of liquid that evaporates tends to be small.
However, if too much non-alcoholic disinfectant is applied to the hands, it takes time for it to evaporate, and if too little liquid is applied, it may not be applied evenly, which may result in insufficient disinfection. Therefore, the development of wipes made of non-woven fabrics or other materials impregnated with non-alcoholic disinfectants is underway. Wipe sheets make it easy to spread an appropriate amount on the hands and fingers, and make it easy to remove foreign matter from the skin surface.

An example of a non-alcohol disinfectant is a hand disinfectant containing a quaternary ammonium compound. Disinfectants are often used by impregnating a sheet-like substrate (hydrophilic sheet-like substrate) containing cellulose-based fibers such as absorbent cotton or gauze. However, impregnating the hydrophilic sheet-like substrate with a disinfectant containing a quaternary ammonium compound, which is a bactericidal component, causes problems such as the bactericidal component being adsorbed onto the sheet-like substrate (Non-Patent Document 1).

In order to solve the above problem, it has been proposed to add ethanol to a chemical solution containing a quaternary ammonium compound to suppress the amount of the quaternary ammonium compound adsorbed to the sheet-like substrate (Patent Document 1). However, with non-alcoholic disinfectants, it is difficult to suppress adsorption, and there is a risk that the bactericidal power will be significantly reduced.
Therefore, there has been a demand for an ethanol-free wiping sheet that has excellent moisture retention while suppressing the adsorption of quaternary ammonium compounds to hydrophilic sheet-like substrates and the evaporation of the impregnation liquid.

JP 2012-197250 A

Adsorption of disinfectants to absorbent cotton, etc. Y's Letter Vol. 2 No. 7 (2005) Yoshida Pharmaceutical Co., Ltd.

The object of the present invention is to provide a wiping sheet in which a sheet-like substrate containing cellulose fibers is impregnated with a disinfectant composition, which inhibits the adsorption of the quaternary ammonium compound contained in the disinfectant composition to the sheet-like substrate without using a lower monovalent alcohol, inhibits the evaporation of the disinfectant composition, which is the impregnating liquid, and has excellent moisturizing properties when used on the skin.

Means for Solving the Problems The present inventors conducted intensive research to solve the above problems, and as a result, discovered that by using a disinfectant composition containing specific amounts of (a) a quaternary ammonium compound having a specific structure, and (b) a hydroxymonocarboxylic acid having 2 to 6 carbon atoms and a salt thereof, and further having a pH within a specified range, and impregnating a sheet-like substrate containing cellulosic fibers with the disinfectant composition, it is possible to obtain a wiping sheet having excellent moisture retention while suppressing adsorption of the quaternary ammonium compound to the sheet-like substrate and evaporation of the impregnation liquid, and thus completed the present invention.
That is, the wiping sheet of the present invention is as follows.

[1] A wiping sheet comprising a sheet-like substrate containing cellulose-based fibers impregnated with a disinfectant composition, the disinfectant composition comprising: (a) a quaternary ammonium compound having a structure represented by formula (1) at 0.005 to 1.0 w/v%,
(b) containing 0.005 to 5.0 w/v % of a hydroxymonocarboxylic acid having 2 to 6 carbon atoms and 0.005 to 5.0 w/v % of a salt thereof;
The pH is 3.0 to 6.0,
A wiping sheet that does not contain a monohydric lower alcohol.

(In formula (1), R is a substituent having 8 to 18 carbon atoms.)
[2] The wipe sheet according to the above-mentioned [1], wherein the disinfectant composition further contains 0.01 to 5.0 w/v % of a phenolic compound having a structure of formula (2).

(In formula (2), R ¹ is a hydrogen atom or a substituent having 4 or less carbon atoms and an ester skeleton, and R ² is a hydrogen atom or a substituent having 4 or less carbon atoms and a hydroxyl group.)

According to the present invention, a wiping sheet is provided in which a sheet-like substrate containing cellulose-based fibers is impregnated with a disinfectant composition, and the adsorption of the quaternary ammonium compound contained in the disinfectant composition to the sheet-like substrate is suppressed without using a lower monovalent alcohol, and the evaporation of the disinfectant composition, which is the impregnating liquid, is suppressed, while the wiping sheet has excellent moisture retention when used on the skin.

The present invention will now be described in further detail.
In this specification, when a preferred numerical range (e.g., content, etc.) is described in stages, each lower limit and upper limit can be combined independently. For example, in the description "preferably 10 to 100, more preferably 20 to 90", "preferable lower limit: 10" and "more preferably upper limit: 90" can be combined to give "10 to 90".

The present invention relates to a wiping sheet comprising a sheet-like substrate containing cellulose-based fibers impregnated with a disinfectant composition, the disinfectant composition comprising:
(a) 0.005 to 1.0 w/v % of a quaternary ammonium compound having a structure of formula (1),
(b) A wiping sheet containing 0.005 to 5.0 w/v % of a hydroxymonocarboxylic acid having 2 to 6 carbon atoms and 0.005 to 5.0 w/v % of a salt thereof, having a pH of 3.0 to 6.0, and containing no lower monohydric alcohol.

(In formula (1), R is a substituent having 8 to 18 carbon atoms.)
The present invention will be described in detail below.

[Wipe sheet]
The wiping sheet of the present invention is obtained by impregnating a sheet-like substrate containing cellulosic fibers with a disinfectant composition.

Disinfectant Composition
The disinfectant composition of the present invention contains (a) 0.005 to 1.0 w/v % of a quaternary ammonium compound having a structure of formula (1), (b) 0.005 to 5.0 w/v % of a hydroxymonocarboxylic acid having 2 to 6 carbon atoms and 0.005 to 5.0 w/v % of a salt thereof, has a pH of 3.0 to 6.0, and does not contain a monohydric lower alcohol.

The disinfectant composition does not contain a monohydric lower alcohol. By not containing a monohydric lower alcohol, the disinfectant composition is less irritating to the skin and is easy to use for users who are sensitive to alcohol. In addition, by not containing a monohydric lower alcohol, the disinfectant composition is prevented from evaporating after the sheet-like substrate is impregnated with the disinfectant composition, and the water retention of the wipe sheet can be improved.
Here, the term "lower monohydric alcohol" refers to a monovalent alcohol having 1 to 3 carbon atoms. Note that "not containing a lower monohydric alcohol" means that a lower monohydric alcohol is not intentionally blended, and for example, a lower monohydric alcohol that may be contained as an unavoidable impurity in the disinfectant composition is permitted.

<(a) Quaternary Ammonium Compound>
The disinfectant composition of the present invention contains (a) a quaternary ammonium compound having a structure of formula (1) (hereinafter also referred to as component (a)).

(In formula (1), R is a substituent having 8 to 18 carbon atoms.)

In formula (1), R ¹ is preferably a hydrocarbon group having 8 to 18 carbon atoms, a group having 8 to 18 carbon atoms and an oxygen atom, among other substituents having 8 to 18 carbon atoms.

The hydrocarbon group having 8 to 18 carbon atoms is not particularly limited, but is preferably an alkyl group having 8 to 18 carbon atoms. The alkyl group having 8 to 18 carbon atoms may be linear or branched, and examples thereof include an octyl group, a 2-ethylhexyl group, an isooctyl group, a nonyl group, a decyl group, a dodecyl group, a tridecyl group, a tetradecyl group, a pentadecyl group, a hexadecyl group, a heptadecyl group, a hexadecyl group, and an octadecyl group.

Examples of the group having 8 to 18 carbon atoms and containing an oxygen atom include hydrocarbon groups having an oxygen atom, and among these, aromatic hydrocarbon groups having an alkylene ether moiety [-(R-O) _n -: R is an alkylene group having 1 to 3 carbon atoms, preferably an ethylene group, and n is an integer of 1 to 3, preferably 2] are preferred.

Specific examples of the quaternary ammonium compound having the structure of formula (1) include benzalkonium chloride, benzethonium chloride, etc. Among them, benzalkonium chloride is more preferred because of its wide range of application to the body. The component (a) contained in the disinfectant composition of the present invention may be one type or two or more types in combination.
The content of component (a) in the disinfectant composition of the present invention is 0.005 to 1.0 w/v %. If the content of component (a) is less than 0.005 w/v %, it may not be possible to exert a broad bactericidal spectrum. On the other hand, if the content of component (a) is more than 1.0 w/v %, it is not preferable from the viewpoint of cost-effectiveness because a significant improvement in bactericidal power cannot be expected.
From the viewpoint of bactericidal effect, the content of the component (a) of the present invention is preferably 0.01 w/v% to 0.5 w/v%, more preferably 0.025 w/v% to 0.25 w/v%, and even more preferably 0.05 w/v% to 0.2 w/v%. When two or more types of the component (a) are contained, the content of the component (a) means the total amount of the components (a).

<(b) Hydroxymonocarboxylic acid having 2 to 6 carbon atoms and its salt>
The disinfectant composition of the present invention contains (b) a hydroxymonocarboxylic acid having 2 to 6 carbon atoms and a salt thereof (hereinafter also referred to as component (b)). In the present invention, the hydroxymonocarboxylic acid refers to a carboxylic acid having one or more hydroxy groups and a valence of 1 (the number of carboxyl groups is 1).
Of the component (b) contained in the disinfectant composition of the present invention, the hydroxymonocarboxylic acid having 2 to 6 carbon atoms is not particularly limited as long as it is a compound having 2 to 6 carbon atoms corresponding to the above-mentioned hydroxymonocarboxylic acid, and specific examples thereof include glycolic acid, lactic acid, glyceric acid, 3-hydroxypropionic acid, 1-hydroxybutyric acid, 2-hydroxybutyric acid, gluconic acid, pantoic acid, mevalonic acid, 2,3-dihydroxy-3-methylpentanoic acid, etc. These hydroxymonocarboxylic acids having 2 to 6 carbon atoms may be in any of the D-, L-, and DL-forms.

The disinfectant composition of the present invention may contain at least one hydroxymonocarboxylic acid having 2 to 6 carbon atoms, and may contain a combination of two or more hydroxymonocarboxylic acids having 2 to 6 carbon atoms.
From the viewpoint of bactericidal activity, the hydroxymonocarboxylic acid having 2 to 6 carbon atoms contained in the disinfectant composition of the present invention is preferably lactic acid or gluconic acid, more preferably lactic acid.

Of the component (b) contained in the disinfectant composition of the present invention, the salt of a hydroxymonocarboxylate having 2 to 6 carbon atoms is not particularly limited as long as it is a salt of a hydroxymonocarboxylate having 2 to 6 carbon atoms, and examples thereof include sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts of the above-mentioned hydroxymonocarboxylates having 2 to 6 carbon atoms.
The salt of a hydroxymonocarboxylate having 2 to 6 carbon atoms contained in the disinfectant composition of the present invention is preferably sodium glycolate, sodium lactate, potassium lactate, sodium gluconate, potassium gluconate, or calcium pantoate, and more preferably sodium lactate or sodium gluconate.

There are no limitations on the method of addition of the hydroxymonocarboxylate having 2 to 6 carbon atoms contained in the disinfectant composition of the present invention. For example, instead of adding sodium lactate directly, lactic acid and sodium hydroxide may be added to form sodium lactate in the disinfectant composition, which can be considered to be the addition of sodium lactate.

In the (b) component, the content of the hydroxymonocarboxylic acid having 2 to 6 carbon atoms is 0.005 to 5.0 w/v %. If the content is less than 0.005 w/v %, there is a risk that the adsorption of the quaternary ammonium compound to the sheet-like substrate containing cellulose fibers cannot be suppressed. If the content is more than 5.0 w/v %, there is a risk that irritation to the skin will be strong.
In the component (b) of the present invention, the content of the hydroxymonocarboxylic acid having 2 to 6 carbon atoms is preferably 0.01 to 2.0 w/v %, more preferably 0.05 to 0.5 w/v %, in order to suppress adsorption of the quaternary ammonium compound to the sheet-like substrate containing cellulose fibers. When two or more kinds of hydroxymonocarboxylic acids having 2 to 6 carbon atoms are used, the content of the hydroxymonocarboxylic acid having 2 to 6 carbon atoms means the total amount thereof.

In the component (b) of the present invention, the content of the hydroxymonocarboxylate having 2 to 6 carbon atoms is 0.005 to 5.0 w/v %. If the content is less than 0.005 w/v % or more than 5.0 w/v %, it may be difficult to control the pH to the target value.
In the component (b) of the present invention, the content of the hydroxymonocarboxylate having 2 to 6 carbon atoms is preferably 0.05 to 4.0 w/v %, more preferably 0.2 to 3.0 w/v %, and even more preferably 1.0 to 2.5 w/v %, from the viewpoint of ease of control to a target pH. When two or more kinds of hydroxymonocarboxylate having 2 to 6 carbon atoms are used, the content of the hydroxymonocarboxylate means the total amount thereof.

<pH of disinfectant composition>
The pH of the disinfectant composition of the present invention is 3.0 to 6.0. If the pH is lower than 3.0 or higher than 6.0, there is a risk of severe irritation to the skin.
The pH of the disinfectant composition of the present invention is preferably 3.5 to 5.5, more preferably 4.0 to 5.0, from the viewpoints of stability and disinfecting power.
The pH is measured in accordance with General Test Method 2.54 of the Japanese Pharmacopoeia, 17th Edition.

<Phenol compounds>
In addition to the above components, the disinfectant composition of the present invention may contain a phenolic compound having the structure of formula (2) (hereinafter, also simply referred to as a phenolic compound). By using the phenolic compound, it is possible to improve the bactericidal power and virus inactivation effect of the disinfectant composition.

In formula (2), R ¹ is a hydrogen atom or a substituent having 4 or less carbon atoms and an ester skeleton, and R ² is a hydrogen atom or a substituent having 4 or less carbon atoms and a hydroxyl group.

The substituent having an ester skeleton and 4 or less carbon atoms in R ¹ is preferably a group represented by the following formula (3).
-C(=O)OR ³ (3)
In formula (3), ^R3 is an alkyl group having 1 to 4 carbon atoms, and is preferably a methyl group.
The substituent having 4 or less carbon atoms and a hydroxyl group in ^R2 is preferably a group represented by the following formula (4).
-R ⁴ -OH (4)
In formula (4), R ⁴ is an alkylene group having 1 to 4 carbon atoms, and is preferably an ethylene group.

The phenolic compound represented by formula (2) is preferably phenoxyethanol or methyl paraoxybenzoate. The phenolic compound may be used alone or in combination of two or more kinds.

The content of the phenolic compound in the disinfectant composition of the present invention is preferably 0.01 to 5.0 w/v %. This range can particularly enhance the effect against bacteria, fungi, and viruses. The content of the phenolic compound is more preferably 0.1 to 1.0 w/v %. When two or more types of phenolic compounds are used, the content refers to the total amount.

<MPC Copolymer>
The disinfectant composition of the present invention may contain a copolymer containing a structural unit based on 2-(meth)acryloyloxyethyl phosphorylcholine (MPC) (hereinafter sometimes referred to as "MPC copolymer") as a moisturizing agent.
Examples of MPC copolymers include copolymers containing a constituent unit based on 2-(meth)acryloyloxyethyl phosphorylcholine (MPC) (hereinafter referred to as a "constituent unit based on MPC") and a constituent unit based on a hydrophobic monomer, and examples of the constituent unit based on a hydrophobic monomer include constituent units based on (meth)acrylic acid alkyl esters, (meth)acrylamide derivatives, and the like.
In this specification, "(meth)acryloyl" means "acryloyl or methacryloyl", and "(meth)acrylic acid" means "acrylic acid or methacrylic acid".

The constitutional unit based on MPC is represented by the following formula (5).

In the formula (5), ^R6 represents a hydrogen atom or a methyl group.

The structural unit based on an alkyl (meth)acrylate is represented by the following formula (6).

In the general formula (6), R ⁷ is a hydrogen atom or a methyl group, and R ⁸ is a hydrocarbon group having 1 to 24 carbon atoms.

In general formula (6), the hydrocarbon group represented by ^R8 is a linear or branched hydrocarbon group having 1 to 24 carbon atoms, and examples of such groups include a methyl group, an ethyl group, a propyl group, a butyl group, a pentyl group, a hexyl group, a heptyl group, an octyl group, a decyl group, a dodecyl group, a tridecyl group, a tetradecyl group, a pentadecyl group, a hexadecyl group, a heptadecyl group, an octadecyl group, and a docosyl group.
Therefore, examples of structural units based on the (meth)acrylic acid alkyl ester represented by formula (6) include structural units based on methyl (meth)acrylate, ethyl (meth)acrylate, propyl (meth)acrylate, butyl (meth)acrylate, 2-ethylhexyl (meth)acrylate, dodecyl (lauryl) (meth)acrylate, tridecyl (meth)acrylate, octadecyl (stearyl) (meth)acrylate, docosyl (behenyl) (meth)acrylate, and the like.

Further, examples of structural units based on an alkyl (meth)acrylate include diethylaminoethyl (meth)acrylate, trifluoroethyl (meth)acrylate, heptadecafluorodecyl (meth)acrylate, and the like; (meth)acrylates in which the alkyl group represented by R ⁸ in the above formula (6) is substituted with a dialkylamino group, a halogen atom, or the like; and structural units based on 2-hydroxy-3-(meth)acryloyloxypropyltrimethylammonium chloride having a structure in which the alkyl group represented by R ⁸ is substituted with a hydroxyl group and a quaternary ammonio group.

The MPC copolymer has at least a structural unit based on MPC [structural unit (5)] and a structural unit based on a hydrophobic monomer [structural unit (6)], and may contain, for example, a hydrophilic structural unit. Similarly, it may contain a plurality of hydrophobic structural units. The copolymerization ratio of formula (5) and formula (6) is 70/30 to 90/10 in molar ratio. The weight average molecular weight (Mw) of the MPC copolymer is 10,000 to 5,000,000.
The weight average molecular weight of the MPC copolymer is measured by gel permeation chromatography (GPC) and is expressed as a pullulan-equivalent molecular weight.

The polymerization form of the MPC copolymer is not particularly limited, and may be a random copolymer or a block copolymer, with a random copolymer being preferred.
Furthermore, the MPC copolymer may be a copolymer containing other structural units in addition to the structural units based on MPC and the structural units based on a hydrophobic monomer.
The other structural units can be appropriately selected from those that can normally be structural units of a copolymer, so long as they do not affect the effects of the present invention.

Examples of other structural units include structural units based on alkenyl esters of (meth)acrylic acid, such as allyl (meth)acrylate; cyclic alkyl esters of (meth)acrylic acid, such as cyclohexyl (meth)acrylate; (meth)acrylic acid esters having an alkyl group substituted with a heterocycle, such as tetrahydrofurfuryl (meth)acrylate; (meth)acrylic acid esters containing an aromatic group, such as benzyl (meth)acrylate and phenoxyethyl (meth)acrylate; esters of (meth)acrylic acid and monoterpene alcohols, such as isobornyl (meth)acrylate; glycidyl (meth)acrylate; styrene-based monomers, such as styrene, methylstyrene, and chloromethylstyrene; vinyl ether-based monomers, such as methyl vinyl ether and butyl vinyl ether; and vinyl ester-based monomers, such as vinyl acetate and vinyl propionate.
These other structural units may be contained in one or more types, and the content thereof in the MPC copolymer is 40 mol % or less, preferably 20 mol % or less, based on the total amount of structural units based on MPC and structural units based on hydrophobic monomers.

The MPC copolymer can be produced by a known production method.
For example, it can be produced by polymerizing a monomer mixture containing hydrophobic monomers such as MPC and (meth)acrylic acid alkyl ester, and, if necessary, monomers corresponding to the other structural units described above, in the presence of a radical polymerization initiator and under an inert gas atmosphere such as nitrogen, by a known method such as solution polymerization.
In this case, the content ratio of each monomer may be set to a ratio corresponding to the content ratio of each constituent unit in the MPC copolymer.

In the liquid composition of the present invention, one type of the above-mentioned MPC copolymer may be selected and contained alone, or two or more types may be selected and contained in combination.
The MPC copolymer contained in the disinfecting composition of the present invention may be in any form of a solid such as a powder, or a liquid such as a solution or dispersion.

The content of the MPC copolymer in the disinfectant composition is not particularly limited, but from the viewpoint of suppressing evaporation of the disinfectant composition and increasing the water retention of the wiping sheet, it is preferably 0.001 to 1 w/v%, and more preferably 0.01 to 0.5 w/v%.

<Other ingredients>
The disinfectant composition of the present invention may contain, in addition to the above-mentioned components, other components such as a moisturizer, an emollient, a thickener, a bactericide, a solubilizer, an acidic component, or a basic component other than the above-mentioned MPC copolymer, as necessary, so long as the effects of the present invention are not impaired.

Examples of moisturizers other than MPC copolymer include glycerin, sorbitol, 1,3-butylene glycol, propylene glycol, pyrrolidone carboxylic acid and its salts, hyaluronic acid and its salts, N-cocoyl-L-arginine ethyl ester DL-pyrrolidone carboxylate, urea, etc. One or more of these may be contained as moisturizers.

Examples of emollients include isopropyl myristate, isopropyl palmitate, isopropyl stearate, isobutyl oleate, and isobutyl maleate. One or more of these emollients may be included.

Examples of thickeners include natural polysaccharides and their derivatives, specifically carboxymethyl starch, dialdehyde starch, pullulan, mannan, amylopectin, amylose, dextran, hydroxyethyl dextran, levan, inulin, chitin, chitosan, xyloglucan, alginic acid, gum arabic, guar gum, tragacanth gum, heparin, methylcellulose, carboxymethylethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, ethylhydroxyethylcellulose, hydroxypropylmethylcellulose, etc. One or more of these may be contained.

Examples of disinfectants include phenolic compounds such as cresol, iodine compounds such as iodine ions, iodine ions, and iodophores, dye compounds such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, and acrinol, biguanide compounds such as chlorhexidine gluconate, chlorhexidine hydrochloride, chlorhexidine acetate, and polyhexamethylene biguanide, aminocarboxylates such as alkyldiaminoethylglycine hydrochloride and alkylpolyaminoethylglycine hydrochloride, and oxidants such as hydrogen peroxide and potassium permanganate. One or more of these may be contained.

Examples of solubilizers include polyoxyethylene hydrogenated castor oil, polyethylene glycol monolaurate, polyethylene glycol monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene lauryl ether, polyoxyethylene cetyl ether, etc. One or more of these may be contained.

Examples of acidic components include phosphoric acid, citric acid, sulfuric acid, acetic acid, boric acid, hydrochloric acid, etc. One or more of these may be contained.

Examples of basic components include alkali metal hydroxides such as sodium hydroxide and potassium hydroxide, alkanolamines such as monoethanolamine, diethanolamine, triethanolamine, monoisopropanolamine, diisopropanolamine and triisopropanolamine, alkylamines such as 2-amino-2-methyl-1-propanol and 2-amino-2-methyl-1,3-propanediol, and basic amino acids such as lysine and arginine. One or more of these may be included.

The disinfectant composition of the present invention is prepared by dissolving the above-mentioned components (a) and (b), as well as the above-mentioned phenolic compound, MPC copolymer, and other components, which are blended as necessary, in water. A wiping sheet is obtained by impregnating a sheet-shaped substrate with the disinfectant composition, as described below.

(Sheet-like substrate)
The sheet-like substrate in the present invention is a sheet-like substrate containing cellulosic fibers and is a hydrophilic substrate.
The cellulose-based fiber is not particularly limited and may be appropriately selected depending on the purpose. Examples of the cellulose-based fiber include natural cellulose-based fibers such as cotton, pulp, and hemp; viscose rayon obtained from pulp; cuprammonium rayon (cupra); and regenerated cellulose-based fibers such as Lyocell, which is a solvent-spun rayon; and Tencel.
The sheet-like substrate may contain a hydrophobic material such as hydrophobic fibers, so long as the hydrophobic material exhibits hydrophilicity.

Examples of the sheet-like substrate include paper, wet nonwoven fabric, dry nonwoven fabric, woven fabric, and knitted fabric.
The sheet-like substrate preferably has a basis weight of 30 g/m ² to 60 g/m ² , and more preferably has a basis weight of 35 g/m ² to 55 g/m ² .

(Impregnation)
The wiping sheet of the present invention can be obtained by impregnating a sheet-like substrate with the disinfectant composition. The method of impregnation is not particularly limited and can be appropriately selected depending on the purpose, and examples thereof include a method of impregnating a sheet-like substrate by dropping or spraying the disinfectant composition, a method of impregnating a sheet-like substrate by immersing the sheet-like substrate in the disinfectant composition, and a method of storing the sheet-like substrate in a packaging device such as an aluminum pouch, filling the disinfectant composition therein, and sealing the same.
The amount of the disinfectant composition to be impregnated is preferably 1.5 g to 5.0 g, and more preferably 2.0 g to 4.0 g, per gram of the sheet-like substrate in order to sufficiently impregnate the sheet-like substrate with the disinfectant composition.

The cleaning sheet of the present invention is used in a state where it is contained in a packaging device. The packaging device is not particularly limited, and any packaging device that is usually used for cleaning sheets can be used.
The cleaning sheet of the present invention can be suitably used, for example, as a deodorant sheet, a facial sweat wipe, a body sweat wipe, an antiperspirant sheet, a wet hand wipe, a foot wipe, a bottom wipe, a cleaning sheet for nursing care, a sheet for wiping off sebum, a sheet for waking up from sleepiness, a disinfectant sheet, and the like.

The present invention will be described in more detail below with reference to examples and comparative examples, but the present invention is not limited to these. The components used in the examples are as follows.

[Components of disinfectant composition]
<Component (a)>
Benzalkonium chloride Benzethonium chloride <ingredient (b)>
Sodium lactate (phenolic compound)
Phenoxyethanol Methyl parahydroxybenzoate

<Other ingredients>
Moisturizer: MPC copolymer Common ingredients: 1,3-butylene glycol, polyethylene glycol monostearate

(Examples 1 to 7, Comparative Examples 1 to 3)
Disinfectant compositions of Examples 1 to 7 were obtained using the blending compositions shown in Table 1. Disinfectant compositions of Comparative Examples 1 to 3 were obtained using the blending compositions shown in Table 2. Using each of these disinfectant compositions, the following evaluations were carried out.
In each table, "g/100 mL" is equivalent to "w/v %." The composition of purified water shown in each table is the remainder after removing each component other than purified water from the disinfectant composition.

<Residual rate of quaternary ammonium compounds in the liquid>
As a sheet-like substrate containing cellulose-based fibers, a sheet substrate was prepared by forming a rayon/pulp nonwoven fabric (basis weight = 40 g/ ^m2 ) into a rectangle (30 cm x 20 cm). The sheet substrate was stored in a polyethylene packaging device. The sheet substrate was filled with 3.5 g of each of the above disinfectant compositions per 1 g of nonwoven fabric, and impregnated to prepare a wiping sheet. The disinfectant composition of the wiping sheet was squeezed out, and the content of the quaternary ammonium compound in the disinfectant composition before and after the impregnation of the sheet substrate was quantified by high performance liquid chromatography. The residual rate of the quaternary ammonium compound was calculated by the following formula and evaluated according to the following criteria.
Residual rate (%) = 100 x [quaternary ammonium content in the disinfectant composition squeezed out from the wipe sheet / quaternary ammonium content in the disinfectant composition before impregnation]
[Evaluation Criteria]
◎: Residual rate of quaternary ammonium compounds is 90% or more. 〇: Residual rate of quaternary ammonium compounds is less than 90% and 80% or more.
△: The remaining rate of quaternary ammonium compounds is less than 80%.

<Transpiration>
As a sheet-like substrate containing cellulose-based fibers, a sheet substrate was prepared by forming a rayon/pulp nonwoven fabric (basis weight = 40 g/m ² ) into a rectangle (30 cm x 20 cm). The sheet substrate was stored in a polyethylene packaging device. The sheet substrate was filled with 3.5 g of each of the above disinfectant compositions per 1 g of nonwoven fabric, and impregnated to prepare a cleaning sheet. The cleaning sheet was left at room temperature for 2 hours, and then used on hands and fingers. Four men and women (25 to 35 years old) were used as panelists, and were scored according to the following scoring criteria in a sensory evaluation. The total score of the four evaluation points was calculated and evaluated according to the following evaluation criteria.
[Scoring criteria]
2 points: I feel the amount of impregnation liquid is sufficient.
1 point: The amount of impregnation liquid is felt to be somewhat sufficient. 0 point: The amount of impregnation liquid is felt to be somewhat insufficient. [Evaluation criteria]
◎: The total score is greater than 6. 〇: The total score is greater than 3 and is 6 or less. △: The total score is 3 or less.

<Moisturizing properties>
The disinfectant composition prepared as described above was applied to four male and female panelists (aged 25 to 35 years) five times every hour after washing the forearms with soap, and this was continued for five days. The moisturizing feeling of the skin after five days was scored by sensory evaluation according to the following scoring criteria. The total score of the four panelists was calculated and evaluated according to the following criteria.
[Scoring criteria]
2 points: Very moisturizing feeling 1 point: Moisturizing feeling is slightly felt 0 point: Moisturizing feeling is slightly not felt [Evaluation criteria]
◎: The total score is greater than 6. 〇: The total score is greater than 3 and is 6 or less. △: The total score is 3 or less.

As is clear from the results of the Examples in Table 1, the wiping sheets impregnated with the disinfectant composition satisfying the requirements of the present invention have a high residual rate of quaternary ammonium compounds, which indicates that the adsorption of quaternary ammonium compounds is suppressed. In addition, the results of the transpiration are also good, which indicates that the transpiration of the disinfectant composition is suppressed, and the moisturizing properties are also good.
In contrast, as is clear from the results of the comparative examples in Table 2, wiping sheets impregnated with disinfectant compositions that do not satisfy the requirements of the present invention had poor transpiration and moisture retention properties, even when the quaternary ammonium compounds were easily adsorbed or the adsorption of the quaternary ammonium compounds was suppressed.

Claims (2)

A wiping sheet comprising a sheet-like substrate containing cellulose-based fibers impregnated with a disinfectant composition, the disinfectant composition comprising: (a) 0.005 to 1.0 w/v % of a quaternary ammonium compound having a structure of formula (1):
(b) 0.005 to 5.0 w/v % of a hydroxymonocarboxylic acid having 2 to 6 carbon atoms and 0.005 to 5.0 w/v % of a salt thereof ,
(c) containing 0.001 to 1 w/v % of a copolymer (MPC copolymer) containing a structural unit based on 2-(meth)acryloyloxyethyl phosphorylcholine (MPC);
The quaternary ammonium compound having the structure of the formula (1) is at least one selected from benzalkonium chloride and benzethonium chloride,
The hydroxymonocarboxylic acid having 2 to 6 carbon atoms and the salt thereof are lactic acid and sodium lactate, respectively;
The pH is 3.0 to 6.0,
A wiping sheet that does not contain a monohydric lower alcohol.
(In formula (1), R is a substituent having 8 to 18 carbon atoms.) The wipe sheet according to claim 1, wherein the disinfectant composition further contains 0.01 to 5.0 w/v % of a phenolic compound having a structure of formula (2).
(In formula (2), R ¹ is a hydrogen atom or a substituent having 4 or less carbon atoms and an ester skeleton, and R ² is a hydrogen atom or a substituent having 4 or less carbon atoms and a hydroxyl group.)