JP7702727B2 - blood separation equipment - Google Patents

Description

The present invention relates to a blood separation device, and in particular to a blood separation device that has a simple structure and can prevent broken pieces of parts from being mixed into a blood sample.

Conventionally, there is known a biological sample separation device that can separate blood collected from a subject without using a centrifuge (see, for example, Patent Document 1). The biological sample separation device of Patent Document 1 has a blood collection container and a cylinder that is inserted into the blood collection container, and the cylinder is provided with a separation membrane that separates the blood. Blood collected from the subject is placed in the blood collection container, and by inserting the cylinder into the blood collection container, the blood passes through the separation membrane and is separated into blood cell components and serum or plasma.

JP 2003-270239 A

The biological sample separation device of Patent Document 1 is configured so that a thin-walled portion of the cylinder breaks while the cylinder is being inserted into the blood collection container, so that the cylinder can be moved to the back of the blood collection container. However, the thin-walled portion is a disk-shaped area that expands in the radial direction of the cylinder, and in Patent Document 1, this thin-walled portion is broken by twisting it off. Therefore, the manner in which the thin-walled portion breaks varies depending on how hard the user turns the knob, and in some cases, broken pieces may become mixed into the cylinder.

The present invention was made in consideration of these points, and aims to provide a blood separation device that can separate blood without using a centrifuge, has a simple structure, and can prevent broken pieces of parts from being mixed into the blood sample.

The blood separation instrument of the present invention comprises: a container body having a storage portion for storing blood collected from a subject;
a blood separation cylinder that is formed in a cylindrical shape, has a filter material for separating blood provided therein, and is inserted into the storage portion from above;
a cover member that is attached to the upper end of the container body by screwing when the blood separation cylinder is inserted into the storage portion,
A blood separating device in which blood is separated by the filter material while the blood separation cylinder is inserted into the container by being pushed by the cover member as the cover member is screwed in,
The cover member has a core rod with a sealing plug attached to a tip thereof,
the blood separation cylinder has a stopper piece that comes into contact with the lid member when the lid member is screwed in,
When the cover member is screwed in, the blood separation cylinder is inserted to a first position by being pushed by the cover member while maintaining the relative axial positional relationship between the core rod and the blood separation cylinder,
As the lid member is screwed further in, the stopper piece undergoes plastic deformation, allowing the core rod to move toward the back of the blood separation cylinder, and when the lid member is screwed into a fixed position, the sealing plug fits into the through hole in the blood separation cylinder, closing the through hole.

In one embodiment of the present invention, the blood separation cylinder is cylindrical, and the stopper piece is formed so as to protrude from the upper end of the blood separation cylinder toward the lid member.

In one embodiment of the present invention, a pair of stopper pieces are provided, with the first stopper piece and the second stopper piece being formed at 180° intervals in the circumferential direction of the blood separation cylinder.

In one embodiment of the present invention, the stopper piece has a protruding portion that contacts the lid member, and a support portion that connects the protruding portion to the cylindrical portion of the blood separation cylinder and is formed so as to deform preferentially when the stopper piece undergoes plastic deformation.

In one embodiment of the present invention, the protruding portion of the stopper piece is configured to fall toward the radial inside of the blood separation cylinder while the lid member is being screwed toward the fixed position.

In one embodiment of the present invention, the support portion is configured to break while the cover member is being screwed into the fixed position, thereby reducing the amount of protrusion of the protrusion and allowing the core rod to move toward the rear of the blood separation cylinder.

In one embodiment of the present invention, the top of the protrusion is formed in a semicircular shape.

In one embodiment of the present invention, the screw connection between the threaded portion of the container body and the threaded portion of the lid member is configured such that the lid member must be rotated 1440° or more from the time the threaded portions engage with each other until the lid member is screwed into the fixed position.

In one embodiment of the present invention, the sealing plug is configured to come off from the core rod when the cover member is turned and the core rod is pulled out after the sealing plug is once fitted into the through hole.

(Explanation of terms)
When separating blood, depending on the purpose of the test, the blood may be separated into blood cell components and plasma, or into blood cell components and serum; however, in this specification, no detailed distinction is made between these, and it may be expressed, for example, as "separating into blood cell components and plasma, etc."

The present invention provides a blood separation device that can separate blood without using a centrifuge, and has a simple structure that can prevent broken pieces of parts from being mixed into the blood sample.

FIG. 2 is a diagram showing components of a blood separation device separated from each other. 2A and 2B are diagrams showing a container body, in which FIG. 2A is a front view and FIG. 2B is a bottom view. 3A and 3B are diagrams showing a blood separation cylinder, in which FIG. 3A is a plan view and FIG. 3B is a front view. FIG. 2 is a cross-sectional view of a liquid separating cylinder. 1 is a flowchart showing a procedure for using the blood separation instrument. 13A and 13B are diagrams showing how the blood separation cylinder is being inserted into the container body. 11A and 11B are diagrams illustrating a state in which the stopper pieces are deformed so as to fall radially inward;

The following describes in detail an embodiment of the present invention with reference to the accompanying drawings. Fig. 1 is a diagram showing the components of a blood separation device separated. Fig. 2 is a diagram showing a container body, with Fig. 2(a) being a front view and Fig. 2(b) being a bottom view. Fig. 3 is a diagram showing a blood separation cylinder, with Fig. 3(a) being a plan view and Fig. 3(b) being a front view. Fig. 4 is a cross-sectional view of a liquid separation cylinder. In the following description, terms indicating directions such as "up and down" and "left and right" are used to correspond to the directions of the components depicted in the drawings.

As shown in FIG. 1, the blood separation instrument 1 of this embodiment includes a container body 10, a blood separation cylinder 30, and a cover member 50. The blood separation instrument 1 has a function of separating blood collected from a subject and a function of containing and holding the separated blood. In FIG. 1, the symbol Ax indicates the axis of the container body 10, the blood separation cylinder 30, and the cover member 50. As can be seen from FIG. 1, in this embodiment, the blood separation instrument 1 is configured such that the container body 10, the blood separation cylinder 30, and the cover member 50 are coaxial when assembled.

As shown in Figs. 1 and 2, the container body 10 is formed into a cylindrical shape overall, and has a storage section 15 provided inside. The container body 10 is formed of a resin material, as an example. In this embodiment, the resin material is transparent. The storage section 15 is a substantially cylindrical space. A partition wall 17 is formed inside the storage section 15, and this partition wall 17 forms the bottom surface of the storage section 15. In this embodiment, the partition wall 17 is formed into a gently curved concave shape rather than a flat plate shape.

The inner diameter of the storage section 15 may be constant, but in this embodiment, the inner wall of the storage section 15 is slightly tapered, and the inner diameter of the storage section 15 gradually decreases as it approaches the partition wall 17. The storage section 15 stores blood collected from the subject. The storage section 15 may contain a predetermined amount of buffer solution in advance.

The upper end of the storage section 15 is open, and a screw section 13 having a helical thread is formed on the outer periphery of the upper end of the container body 10. This screw section 13 is formed to screw into a screw section of the lid member 50 (detailed illustration omitted) described below, so that the lid member 50 can be attached by screwing it to the container body 10.

Inside the container body 10, a rib 19 is formed below the partition wall 17, which reinforces the partition wall 17. The rib 19 is not limited to a specific shape, but may be formed, for example, in a cross shape.

The blood separation cylinder 30 is a member inserted into the container body 10, and is formed into an elongated cylindrical shape as a whole, as shown in Figures 3 and 4. The internal space 31 of the blood separation cylinder 30 is provided with a liquid component storage section 32, a filter material storage section 33, and a through hole 31h.

The liquid component storage section 32 is a cylindrical space provided inside the blood separation cylinder 30, and as shown in FIG. 4, has a first space 32a and a second space 32b formed below it with a relatively small inner diameter.

The through hole 31h is formed at the annular protrusion 34 formed inside the blood separation cylinder 30. The annular protrusion 34 is a portion formed to protrude radially inward from the inner circumferential surface inside the blood separation cylinder 30. As shown in FIG. 3(b), the through hole 31h is a hole with a circular outline. The center position of the through hole 31h coincides with the axis Ax of the blood separation cylinder 30. The annular protrusion 34 is a structural portion against which the sealing plug 59 provided at the tip of the core rod 57 of the cover member 50 is pressed, as described later. The annular protrusion 34 may be formed with an inverted truncated cone-shaped tapered surface 34s to enhance the sealing performance of the sealing plug 59.

The filter material storage section 33 is formed at the lower end of the inside of the blood separation cylinder 30. The filter material storage section 33 is a cylindrical space and communicates with the liquid component storage section 32 via a through hole 31h. The filter material 21 placed in the filter material storage section 33 is made of a material that allows the passage of plasma or serum in blood but does not allow the passage of blood cell components. The filter material 21 may be, for example, a separation membrane.

A rubber gasket 42 is attached to the outer periphery of the lower end of the blood separation cylinder 30 as shown in FIG. 4. The gasket 42 is a member for preventing blood from leaking between the outer periphery of the blood separation cylinder 30 and the inner periphery of the container body 10 when the blood separation cylinder 30 is inserted into the container body 10. The cross-sectional shape of the gasket 42 itself is not particularly limited, and for example, a ribbed annular protrusion or the like may be appropriately provided on the outer periphery.

Next, we will explain the structural parts provided on the outer periphery and upper end of the blood separation cylinder 30.

One or more flanges 38 (see FIG. 3) are formed on the outer periphery of the blood separation cylinder 30. In this example, a first flange 38a and a second flange 38b are formed. The first flange 38a, located at the bottom, abuts against the upper end of the peripheral wall of the container body 10 when the blood separation cylinder 30 is inserted into the container body 10, and has the function of restricting the relative axial movement between the blood separation cylinder 30 and the container body 10.

A pair of stopper pieces 35-1, 35-2 (also simply referred to as stopper pieces 35) are also formed at the upper end of the blood separation cylinder 30. Each stopper piece 35-1, 35-2 protrudes toward the cover member 50 side when the blood separation instrument 1 is assembled. As shown in FIG. 3(b), in this example, the pair of stopper pieces 35-1, 35-2 are formed at 180° intervals along the circumferential direction of the blood separation cylinder. In other words, the two stopper pieces 35-1, 35-2 are formed at equal intervals in the circumferential direction. The stopper piece 35 prevents a sealing plug 59 (described later) from being inserted into the through hole 35h until the final stage of blood separation, and plays a role in maintaining a state in which separated plasma, etc. can flow into the liquid component storage section 32 during blood separation. In this example, the pair of stopper pieces 35-1, 35-2 have the same shape.

More specifically, as shown in FIG. 3(b), the stopper piece 35 has a protrusion 35a that protrudes upward from the upper end of the blood separation cylinder 30, and a support portion 35b that connects the protrusion 35a to the cylindrical portion of the blood separation cylinder 30. The protrusion 35a is formed in a plate shape, and its upper end is a semicircular R portion.

The upper end of the protrusion 35a is a part that moves while rubbing against the inner surface of the lid member 50, as described below. Therefore, it is preferable that such an R portion is formed to allow smooth sliding. In the case of such a shape, the top of the protrusion 35a comes into point contact with the inner surface of the lid member 50, realizing smooth sliding. As shown in the cross-sectional view of Figure 4, an R portion 35r may be formed at the top of the stopper piece 35.

The function of the support portion 35b is that when a force of a predetermined value or more is applied vertically downward (in the axial direction downward of the blood separation cylinder 30) to the protrusion portion 35a, this portion is preferentially plastically deformed, deforming the stopper pieces 35-1, 35-2 radially inward. The support portion 35b may have any shape as long as it has this function. In the example of FIG. 3(a), an opening 37 is formed below the protrusion portion 35a, and the protrusion portion 35a is located above it, and the protrusion portion 35a is connected to the cylindrical portion of the blood separation cylinder 30 by two support portions 35b on both the left and right sides. The height at which the protrusion portion 35a protrudes from the upper surface of the cylindrical portion of the blood separation cylinder 30 depends on the size of the entire product, etc., but is preferably within the range of 1 mm to 10 mm (1 mm or more and 10 mm or less), particularly within the range of 2 mm to 5 mm.

As shown in FIG. 1, the lid member 50 has a lid body 55, a core rod 57, and a sealing plug 59.

The lid body 55 is a member that closes the upper end opening of the blood separation cylinder 30, and has an upper surface portion 51, a cylindrical peripheral wall portion 52 formed downward from the upper surface, and a support portion 53 that supports the core rod 57. A threaded portion (not shown in detail) is formed on the inner surface of the peripheral wall portion 52, and this threaded portion screws into the threaded portion 13 of the blood separation cylinder 30.

The inner surface 51a of the upper surface portion 51 is formed as a flat surface. Although not shown, the inner surface 51a is formed in a circular ring shape when the lid body 55 is viewed from the bottom side. As described below, the inner surface 51a is the surface against which the tip of the protrusion 35a (see FIG. 3) slides when the lid member 50 is attached to the blood separation cylinder 30.

The core rod 57 extends straight along the axis Ax of the lid member 50. Although not limited thereto, the core rod 57 may be formed separately from the lid body 55 and held by the support part 53. Alternatively, the core rod 57 may be provided as a part of the lid member 50.

A sealing plug 59 is attached to the tip of the core rod 57. The sealing plug 59 is made of, for example, an elastic resin material. The sealing plug 59 is a member that is inserted into the through hole 31h to close the hole.

The core rod 57 and the sealing plug 59 may be connected, for example, by inserting the tip of the core rod 57 into a cylindrical hole formed in the sealing plug 59. On the other hand, the core rod 57 may be formed so that when the sealing plug 59 is inserted into the through hole 31h and then the core rod 57 is pulled out, the sealing plug 59 does not come out of the through hole 31h, but the tip of the core rod 57 comes out of the hole in the sealing plug 59. This makes it possible to subject the subject's blood to be subjected to testing while it is still separated.

(Procedure for using blood separator)
The procedure for using the blood separating instrument 1 configured as described above will be described below with reference to Figs. 5 to 8. Fig. 5 is a flow chart showing the procedure for using the blood separating instrument 1. Below, the procedure for a user to collect his/her own blood and store it in the blood separating instrument 1 will be described. Before use, a lancet and a micro-quantity blood collector (not shown) are assumed to be prepared. The instrument for collection does not need to be limited to a specific one, but a micro-quantity blood collector such as that described in Patent No. 5909470 may be used.

First, in step S1, the user pricks the tip of his finger with a microneedle using a lancet, allowing blood to flow out and be collected using the microquantity blood collector. The user transfers the collected blood to the container body 10 by pressing the dropper at the tip of the microquantity blood collector, and mixes it with a buffer solution.

Next, in step 2, the user inserts the core rod 57 having a sealing plug 59 at its tip into the blood separation cylinder 30, and inserts the blood separation cylinder 30 together with the lid member 50 into the container body 10. Until the blood separation cylinder 30 is inserted to a certain position into the container body 10, the threaded portion (not shown) of the lid member 50 and the threaded portion 13 of the container body 10 do not engage with each other, so the user presses the lid member 50 with his or her hand, pushing the blood separation cylinder 30 into the container body 10.

Figure 6 (a) shows a state in which the top of the stopper piece 35 and the inner surface 51a of the lid member 50 are in contact, but the sealing plug 59 has not yet closed the through hole 31h. The blood separation cylinder 30 and the lid member 50 are pushed down to a position where the threaded portion (not shown) of the lid member 50 engages with the threaded portion 13 of the container body 10.

Next, in step 3, the lid member 50 is screwed in to insert the blood separation cylinder 30 into the container body 10. Specifically, as the lid member 50 is screwed into the threaded portion 13 of the container body 10, the blood separation cylinder 30 is pushed slowly downward by the lid member 50. At this time, the blood separation cylinder 30 does not rotate around the axis Ax, but moves only downward. Meanwhile, since the lid member 50 rotates around the axis Ax, the top of the stopper piece 35 and the inner surface 51a of the lid member 50 rotate relatively while rubbing against each other.

As the blood separation cylinder 30 is slowly pushed downward, the mixture of blood and buffer solution contained in the container body 10 passes through the filter material 21. Of the mixture, the liquid components, plasma or serum, pass through the filter material 21 and flow little by little into the blood separation cylinder 30 through the through hole 31h. The blood cell components are prevented from moving by the filter material 21 and remain between the tip of the blood separation cylinder 30 and the container part 15 of the container body 10. Unlike a configuration in which the user manually pushes the blood separation cylinder 30 into the container body 10, for example, a substantially uniform pressure is applied to the mixture during blood separation, preventing hemolysis.

The speed at which the blood separation cylinder 30 moves corresponds to the speed at which the mixture passes through the filter material 21. If the user were to simply push the blood separation cylinder 30 in by hand without using a screw connection, the speed at which the blood separation cylinder 30 moves may become too fast, causing hemolysis. In contrast, the configuration of this embodiment uses the screw connection between the lid member 50 and the screw portion 13 of the container body 10 to slowly push the blood separation cylinder 30 in, allowing blood to be separated well without causing the problem of hemolysis.

The insertion process of step S3 is performed until the blood separation cylinder 30 moves to a first position within the container body 10. Here, the "first position" refers to a state in which the flange portion 38a on the outer periphery of the blood separation cylinder 30 abuts against the upper end of the threaded portion 13 of the container body 10, and the blood separation cylinder 30 cannot be pushed any further into the container body 10.

Next, in step 4, the lid member 50 is screwed further in from the above state. In this state, the movement of the blood separation cylinder 30 is restricted by the flange portion 38, so that as the lid member 50 rotates, it is pressed firmly against the blood separation cylinder 30.

When the lid member 50 is screwed in, as shown in FIG. 6(b), the inner surface 51a of the lid member 50 presses against the stopper piece 35, and the stopper piece 35 gradually undergoes plastic deformation. Specifically, as shown in FIG. 7, the stopper piece 35 deforms so that the pair of protrusions 35a fall radially inward (toward the center of the cylinder). This deformation shortens the overall length of the blood separation cylinder 30 by the dimension h. Therefore, it becomes possible to move the lid member 50 toward the container body 10 by the dimension h (FIG. 7 shows the stopper piece 35 in a partially fallen state in order to clearly show the deformation. The stopper piece 35 may ultimately be configured to fall to an almost right angle. In this case, it becomes possible to move the lid member 50 by the dimension h, which is approximately the same as the height of the stopper piece 35).

The deformation of the stopper piece 35 may be, specifically, a mode in which only the support portion 35b undergoes plastic deformation, causing the protrusion 35a to move radially inward (the shape of the protrusion 35a itself does not change), or a mode in which the stopper piece 35 gradually deforms while the protrusion 35a itself also deforms (for example, the protrusion 35a deforms so that it gradually bends radially inward from the top side). The principle by which the protrusion 35a falls radially inward may be, for example, that the top of the protrusion 35a is pressed against the inner surface of the side wall of the lid member 50 and deformed. In addition, the present invention may also be configured such that after the stopper piece 35 is pressed against the inner surface 51a of the lid member 50, one or both of the support portions 35b break and the protrusion 35a is crushed downward as it is. Specifically, the protrusion 35a moves downward so as to enter the opening 37.

When the lid member 50 is screwed in while deforming the stopper piece 35 in this manner, the sealing plug 59 at the tip of the core rod 57 moves to the through hole 31h as shown in FIG. 7(b), and finally, the sealing plug 59 is pressed into the through hole 31h, closing the through hole 31h (step S5, this position is called the "second position"). Through these steps, the separation and sealing of the blood is completed.

In the configuration of this embodiment, as described above, the partition 17 of the container body 10 is formed into a gently curved concave shape. Therefore, the amount of blood and buffer remaining in the separation membrane between the inner surface of the partition 17 and the filter material 21 at the tip of the cylinder 30 (dead volume) is reduced.

Next, in step S6, the blood separation instrument 1 is transported to a testing center or the like. After that, in step S7, a medical professional unscrews and removes the cover member 50 of the blood separation instrument 1. At this time, the sealing plug 59 at the tip of the core rod 57 comes off the core rod 57, and the through hole 31h remains closed, so the blood remains separated. Thereafter, the blood cell components and the plasma or serum are analyzed using predetermined analytical equipment.

In the blood separation instrument 1 of this embodiment described above, the stopper piece 35 formed at the upper end of the blood separation cylinder 30 has the functions of (i) positioning the sealing plug 59 in front of the through hole 31h until the final stage of blood separation, and (ii) enabling the sealing plug 59 to move and close the through hole 31h after blood separation. The stopper piece 35 is plastically deformed to enable the sealing plug 59 to close the through hole 31h, but since the stopper piece 35 is deformed slowly by the axial force from the cover member 50, the stopper piece 35 is unlikely to break into fragments, and as a result, the broken fragments are prevented from being mixed into the blood sample.

In addition, the stopper piece 35 is integrally formed at the upper end of the peripheral wall of the blood separation cylinder 30, so the above-mentioned functions can be achieved with a simple structure.

The blood separation cylinder of this embodiment, due to its structure described above, is relatively inexpensive, easy for the user to operate, and has the effect of ensuring the amount of serum required for testing for a specified period of time with almost no individual variation.

The present invention is not limited to the above-described embodiment, and various modifications are possible. For example, while there are only two stopper pieces 35 in the above embodiment, three or four or more stopper pieces 35 may be formed.

The shape of the top of the stopper piece 35 (see FIG. 3(b)) is not limited to a semicircular shape, and may be another shape in which the width dimension gradually decreases as it approaches the tip. For example, it may be triangular. Regarding the thickness of the stopper piece 35, for example, the thickness of the protruding portion 35a may be constant throughout, but is not limited to this. For example, the thickness of the protruding portion 35a may be formed to be thinner toward the tip side so that the tip side is more easily deformed.

The screw connection between the screw portion 13 of the container body 10 and the screw portion (not shown) of the lid member 50 may be configured so that the lid member 50 must be rotated four or more times (or 4.5 or more times) from when the screw portions engage with each other until the lid member 50 is screwed into the fixed position. The pitch of the thread can be set appropriately according to the overall size of the product, but may be within a range of, for example, 0.5 mm to 1.5 mm. With this configuration, the blood separation cylinder 30 can be advanced slowly when the lid member 50 is rotated. Even if the lid member 50 loosens from the fixed position and rotates slightly for some reason, there is a sufficient stroke until it reaches a position where the contents leak, so there is no possibility of leakage occurring.

Although the present invention has been described above using embodiments, the technical scope of the present invention is not limited to the scope described in the above embodiments, and various modifications and changes are possible within the scope of the gist of the invention. For example, all or part of the device can be configured by distributing or integrating functionally or physically in any unit. In addition, new embodiments resulting from any combination of multiple embodiments are also included in the embodiments of the present invention. The effect of the new embodiment resulting from the combination also has the effect of the original embodiment.

LIST OF SYMBOLS 1 Blood separation instrument 10 Container body 13 Screw portion 15 Storage portion 17 Partition wall 19 Rib 21 Filter material 30 Blood separation cylinder 31 Internal space 31h Through hole 32 Liquid component storage portion 33 Filter material storage portion 34 Annular protruding portion 34s Tapered surface 35 Stopper piece 35a Protruding portion 35b Support portion 35h Through hole 37 Opening 38 Flange portion 42 Gasket 50 Lid member 51 Upper surface portion 51a Inner surface 52 Peripheral wall portion 53 Support portion 55 Lid body 55h Through hole 57 Core rod 59 Sealing plug

Claims (8)

A container body having a storage portion for storing blood collected from a subject;
a blood separation cylinder that is formed in a cylindrical shape, has a filter material for separating blood provided therein, and is inserted into the storage portion from above;
a cover member that is attached to the upper end of the container body by screwing when the blood separation cylinder is inserted into the storage portion,
A blood separating device in which blood is separated by the filter material while the blood separation cylinder is inserted into the container by being pushed by the cover member as the cover member is screwed in,
The cover member has a core rod with a sealing plug attached to a tip thereof,
the blood separation cylinder has a stopper piece that comes into contact with the lid member when the lid member is screwed in,
When the cover member is screwed in, the blood separation cylinder is inserted to a first position by being pushed by the cover member while maintaining the relative axial positional relationship between the core rod and the blood separation cylinder,
When the cover member is further screwed in, the stopper piece undergoes plastic deformation, thereby allowing the core rod to move toward the rear of the blood separation cylinder, and when the cover member is screwed in to a fixed position, the sealing plug fits into the through hole in the blood separation cylinder to close the through hole.
The stopper piece is
A plate-shaped protruding portion that is a portion that comes into contact with the lid member;
a support portion that connects the protrusion and a cylindrical portion of the blood separation cylinder and is formed so as to deform preferentially when the stopper piece is plastically deformed;
having
The top of the protrusion is formed in a semicircular shape when viewed in the thickness direction of the protrusion.
Blood separation equipment. the blood separation cylinder is cylindrical in shape;
The stopper piece is formed so as to protrude from the upper end of the blood separation cylinder toward the cover member.
The blood separation device according to claim 1 . A pair of the stopper pieces is provided,
The first stopper piece and the second stopper piece are formed at intervals of 180° in the circumferential direction of the blood separation cylinder.
The blood separation device according to claim 2. The protruding portion of the stopper piece is configured to fall toward the radially inner side of the blood separation cylinder while the cover member is being screwed toward a fixed position.
The blood separation device according to any one of claims 1 to 3 . The support portion is configured to break during the process of screwing the cover member toward the fixed position, thereby reducing the amount of protrusion of the protrusion portion and allowing the core rod to move toward the rear side of the blood separation cylinder.
The blood separation device according to any one of claims 1 to 3 . The screw connection between the screw portion of the container body and the screw portion of the lid member is configured such that the lid member must be turned four or more times from when the screw portions engage with each other until the lid member is screwed into a fixed position.
The blood separation device according to any one of claims 1 to 5 . The sealing plug is configured to be detached from the core rod when the cover member is turned and the core rod is pulled out after the sealing plug is once fitted into the through hole.
The blood separation device according to any one of claims 1 to 6 . A container body having a storage portion for storing blood collected from a subject;
a blood separation cylinder that is formed in a cylindrical shape, has a filter material for separating blood provided therein, and is inserted into the storage portion from above;
a cover member that is attached to the upper end of the container body by screwing when the blood separation cylinder is inserted into the storage portion,
A blood separating device in which blood is separated by the filter material while the blood separation cylinder is inserted into the container by being pushed by the cover member as the cover member is screwed in,
The cover member has a core rod with a sealing plug attached to a tip thereof,
the blood separation cylinder has a stopper piece that comes into contact with the lid member when the lid member is screwed in,
When the cover member is screwed in, the blood separation cylinder is inserted to a first position by being pushed by the cover member while maintaining the relative axial positional relationship between the core rod and the blood separation cylinder,
When the cover member is further screwed in, the stopper piece undergoes plastic deformation, thereby allowing the core rod to move toward the rear of the blood separation cylinder, and when the cover member is screwed in to a fixed position, the sealing plug fits into the through hole in the blood separation cylinder to close the through hole.
The protruding portion of the stopper piece is configured to fall toward the radially inner side of the blood separation cylinder while the cover member is being screwed toward a fixed position.
Blood separation equipment .