JP7755403B2 - Cosmetics or topical skin preparations containing 3-O-ethyl ascorbic acid - Google Patents

Description

The present invention relates to a cosmetic or topical skin preparation containing 3-O-ethyl ascorbic acid.

3-O-Ethyl ascorbic acid is a type of ascorbic acid derivative with improved stability, and is widely used as an active ingredient in cosmetics and topical skin preparations. Like ascorbic acid, 3-O-ethyl ascorbic acid possesses a variety of physiologically active properties, including antioxidant properties, skin whitening, collagen production promotion, hyaluronic acid production promotion, intracellular active oxygen scavenging, carbonyl protein inhibition, anti-blue light, and moisturizing properties.

In cosmetics and topical skin preparations, it is common to impart an appropriate viscosity to the preparation to improve usability, such as ease of application and removal from the container. Known thickeners used in cosmetics and topical skin preparations include synthetic polymer thickeners, such as carboxyvinyl polymers and acrylic acid/methacrylic acid alkyl polymers, and polysaccharide thickeners, such as xanthan gum and hydroxyethyl cellulose. However, when incorporating 3-O-ethyl ascorbic acid, common thickeners have problems such as insufficient thickening effect, viscosity loss over time, and poor usability. Furthermore, as described in Patent Document 1, 3-O-ethyl ascorbic acid is known to have improved stability in the acidic pH range. Therefore, thickeners that can be used in preparations containing 3-O-ethyl ascorbic acid over a wide pH range, including the acidic range, are desirable.

As a solution to the above problems, Patent Document 2 proposes thickeners that have a sulfate ester group or a sulfonic acid group in the molecule, or thickeners that have a hydrophobic group but no carboxyl group in the molecule, but the thickening effect and usability of these agents are not necessarily sufficient.

JP 2013-227264 A JP 2010-070492 A

The objective of the present invention is to provide a thickener that can be used in cosmetics or topical skin preparations containing 3-O-ethyl ascorbic acid over a wide pH range, including the acidic range, and that has excellent thickening effect, viscosity stability, and usability.

As a result of extensive research into resolving the above-mentioned problems, the inventors discovered that the above-mentioned problems could be resolved by using cellulose nanofibers with anionic functional groups as a thickener, and thus completed the present invention.

The present invention makes it possible to obtain a cosmetic or topical skin preparation containing 3-O-ethyl ascorbic acid that satisfies all of the following criteria: thickening effect, viscosity stability, and usability.

The cellulose nanofibers having anionic functional groups (component (A)) used in the present invention are fine cellulose fibers obtained by introducing anionic functional groups into cellulose extracted from plant cell walls or the like through chemical treatment, followed by defibration treatment to reduce the size to the nanometer level. Examples of cellulose that can be used as the raw material for the cellulose nanofibers having anionic functional groups of the present invention include wood pulp obtained from softwoods and hardwoods, non-wood pulp obtained from cotton, hemp, bamboo, straw, reed, mulberry, bagasse, kenaf, etc., cellulose isolated from sea squirts, and cellulose isolated from seaweed. The method for producing the cellulose nanofibers having anionic functional groups of the present invention is not particularly limited, and those produced by known chemical and defibration treatments can be used.

The fiber diameter of the cellulose nanofibers having anionic functional groups of the present invention is a number-average fiber diameter of 2 to 150 nm, preferably 2 to 100 nm. The aspect ratio (fiber length/fiber diameter) is not particularly limited, but should be an average of 20 to 10,000, preferably 50 to 2,000. The fiber length and diameter can be determined by image analysis using AFM, TEM, SEM, etc.

Specific examples of anionic functional groups introduced into the cellulose nanofibers of the present invention include carboxyl groups, phosphate groups, and sulfone groups. Cellulose nanofibers into which these anionic functional groups have been introduced are also referred to as carboxylated cellulose nanofibers, phosphated cellulose nanofibers, and sulfonated cellulose nanofibers, respectively. Commercially available products are preferably used as the cellulose nanofibers having anionic functional groups used in the present invention. Specific examples of carboxylated cellulose nanofibers that can be used include Rheocrysta C-2PS (manufactured by Dai-ichi Kogyo Seiyaku Co., Ltd.), Cellenpia TC-01A (manufactured by Nippon Paper Industries Co., Ltd.), and Cellenpia CS-01C (manufactured by Nippon Paper Industries Co., Ltd.); phosphated cellulose nanofibers that can be used include Aurovisco CS (manufactured by Oji Holdings Corporation); and sulfonated cellulose nanofibers that can be used include Stellafine (manufactured by Marusumi Paper Co., Ltd.).

The amount of component (A) blended into the cosmetic or topical skin preparation of the present invention may be adjusted appropriately to achieve the desired properties, and is not particularly limited, but is generally 0.01 to 5% by mass, and preferably 0.05 to 3% by mass.

The 3-O-ethyl ascorbic acid used in the present invention, component (B), is an ascorbic acid derivative in which the hydroxyl group at the 3-position of ascorbic acid has been ethyl etherified. There are no particular restrictions on the method for producing 3-O-ethyl ascorbic acid, and products produced by known methods can be used. A commercially available product, VC Ethyl (trade name), is sold by Nippon Fine Chemical Co., Ltd., and this commercially available product can be preferably used.

The amount of component (B) to be incorporated into the cosmetic or topical skin preparation of the present invention is not particularly limited, but is generally 0.01 to 2% by mass, preferably 0.05 to 1% by mass.

In order to further improve the stability of 3-O-ethyl ascorbic acid, the cosmetic or topical skin preparation of the present invention desirably has a pH of 3 to 6, preferably 3.5 to 5.5. The pH can be adjusted in the usual manner using an acid, alkali, pH adjuster, etc.

Although the cosmetic or topical skin preparation of the present invention contains 3-O-ethyl ascorbic acid, it can be thickened by component (A) over a wide pH range, including the acidic range, allowing it to be adjusted to the desired properties. Furthermore, it exhibits little decrease in viscosity over time and has an excellent feel when used. To further demonstrate these effects, it is more preferable that component (A) be selected from carboxylated cellulose nanofibers and phosphated cellulose nanofibers. Furthermore, from the viewpoints of the transparency of the formulation and the stability of 3-O-ethyl ascorbic acid, phosphated cellulose nanofibers are most preferred.

In order to improve the stability of 3-O-ethyl ascorbic acid, the cosmetic or topical skin preparation of the present invention preferably further contains, as component (C), one or more selected from monohydric alcohols having 1 to 3 carbon atoms and polyhydric alcohols. Specific examples of monohydric alcohols having 1 to 3 carbon atoms include methanol, ethanol, propanol, and isopropyl alcohol. Specific examples of polyhydric alcohols include dihydric alcohols such as ethylene glycol, propylene glycol, 1,3-propanediol, 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, 2-methyl-1,3-propanediol, 3-methyl-1,3-butanediol (isopentyl diol), tetramethylene glycol, hexylene glycol, caprylyl glycol, 1,2-pentanediol (pentylene glycol), 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, and 1,2-decanediol; glycerin, trimethylol Examples of suitable alcohols include trihydric alcohols such as diolpropane and 1,2,6-hexanetriol; sugar alcohols such as sorbitol, xylitol, erythritol, maltitol, mannitol, and pentaerythritol; glyceryl ethers such as ethylglycerin, butylglycerin, hexylglycerin, and ethylhexylglycerin; and polyhydric alcohol polymers such as diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, dipropylene glycol, tripropylene glycol, polypropylene glycol, diglycerin, triglycerin, tetraglycerin, and polyglycerin. These may be used alone or in combination of two or more. Of these, from the viewpoint of the stability of 3-O-ethyl ascorbic acid, ethanol, propylene glycol, 1,3-propanediol, 1,3-butylene glycol, 1,2-pentanediol, glycerin, dipropylene glycol, and diglycerin are preferred, with ethanol, 1,3-butylene glycol, and dipropylene glycol being more preferred. There are no particular restrictions on the amount of component (C) that can be incorporated into the cosmetic or topical skin preparation of the present invention, but from the standpoint of the stability of 3-O-ethylascorbic acid, it is 1 to 50% by mass, preferably 3 to 30% by mass.

The cosmetic or topical skin preparation of the present invention preferably further contains a chelating agent as component (D) for the purpose of improving the stability of 3-O-ethylascorbic acid. Examples of chelating agents include edetic acid (ethylenediaminetetraacetic acid), hydroxyethylethylenediaminetriacetic acid, pentetic acid (diethylenetriaminepentaacetic acid), phytic acid, etidronic acid (hydroxyethanediphosphonic acid), citric acid, gluconic acid, succinic acid, tartaric acid, polyaspartic acid, polyglutamic acid, polyphosphoric acid, metaphosphoric acid, phosphoric acid, and salts thereof. Of these, edetic acid, hydroxyethylethylenediaminetriacetic acid, pentetic acid, etidronic acid, citric acid, and salts thereof are more preferred. The amount of component (D) to be incorporated into the cosmetic or topical skin preparation of the present invention is not particularly limited, but is 0.01 to 5% by mass, preferably 0.05 to 2% by mass, from the viewpoint of the stability of 3-O-ethylascorbic acid.

The cosmetic or topical skin preparation of the present invention may optionally contain water and additives typically incorporated into cosmetics, such as oily bases, moisturizers/touch enhancers, surfactants, polymers/thickeners/gelling agents, antioxidants, reducing agents, oxidizing agents, antioxidants, whitening agents, vitamins and their derivatives, plant/animal/microbial extracts, UV absorbers, antibacterial/preservatives, pH adjusters/acids/alkalis, solvents/propellants, antipruritics, exfoliants/dissolving agents, antiperspirants, cooling agents, astringents, enzymes, nucleic acids, anti-inflammatory/anti-inflammatory agents, hair growth agents/blood circulation promoters/stimulants, hormones, anti-wrinkle/anti-aging agents, irritation soothing agents, cooling agents, warming agents, powders, dyes/colorants/dyes/pigments, fragrances, and the like, to an extent that does not impair the effects of the present invention.

Oil bases include higher alcohols such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, selachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, and 12-hydroxybenzoic acid. Higher fatty acids such as cystearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, long-chain α-hydroxy fatty acids, dimer acids, hydrogenated dimer acids, and their aluminum salts, calcium salts, magnesium salts, zinc salts, potassium salts, sodium salts, and other metal soaps, as well as nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomers, polyisobutene, hydrogenated polyisobutene Hydrocarbons such as propylene glycol, polybutene, squalane, olive-derived squalane, squalene, petrolatum, and solid paraffin; waxes such as candelilla wax, carnauba wax, rice wax, Japan wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, and ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, and hazelnut. Vegetable oils and fats such as tallow oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal oils and fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil; animal waxes such as whale wax, lanolin, orange roughy oil; liquid lanolin, reduced lanolin, adsorbed and purified lanolin, acetated lanolin, acetated liquid lanolin, hydroxylanolin, polyoxyethylene lanolin Lanolins such as lanolin, lanolin fatty acids, hard lanolin fatty acids, lanolin alcohol, lanolin alcohol acetate, and cetyl lanolyl acetate esters; phospholipids such as lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, and sphingomyelin, phosphatidic acid, cyclic lysophosphatidic acid or its salt, and lysolecithin; phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, and partially hydrogenated egg yolk phospholipid; cholesterol sterols such as dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl/behenyl/octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl/octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl/behenyl/octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl esters such as 12-hydroxystearate, cholesteryl macadamia nut oil fatty acid, phytosteryl macadamia nut oil fatty acid, phytosteryl sunflower seed oil fatty acid, phytosteryl isostearate, cholesteryl soft lanolin fatty acid, cholesteryl hard lanolin fatty acid, cholesteryl long-chain branched fatty acid, and cholesteryl long-chain α-hydroxy fatty acid; lipid complexes such as phospholipid-cholesterol complex and phospholipid-phytosterol complex; Octyldodecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinate, dicaprylyl carbonate, dimethicone Hexyldecyl octanoate, octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolinate, methylheptyl laurate, methylheptyl myristate, methylheptyl palmitate, methylheptyl isostearate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, di succinate Monoalcohol carboxylic acid esters such as octyl, triethyl citrate, etc.; oxyacid esters such as cetyl lactate, hydrogenated castor oil monoisostearate, γ-erucalactone, diisostearyl malate, etc.; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, caprylic/capric triglyceride, caprylic/capric/myristic/stearic triglyceride, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate eicosadioate, Trimethylolpropane dioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, pentaerythrityl hydrogenated rosin, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane (isostearate/sebacic acid), pentaerythrityl triethylhexanoate, dipentaerythrityl (hydroxystearate/stearic acid/rosin acid) Polyhydric alcohol fatty acid esters such as ethanol, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca(erucic acid/isostearate/ricinoleic acid) polyglyceryl-8, diglyceryl (hexyldecanoate/sebacic acid) oligoester, glycol distearate (ethylene glycol distearate), 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethyl-1,5-pentanediol dineopentanoate; alkyl ethers such as dicaprylyl ether; diisopropyl dimer dilinoleate derivatives of dimer acids or dimer diols such as diisostearyl dimer dilinoleate, di(isostearyl/phytosteryl) dimer dilinoleate, phytosteryl/behenyl dimer dilinoleate, phytosteryl/isostearyl/cetyl/stearyl/behenyl dimer dilinoleate, dimer dilinoleyl dimer dilinoleate, dimer dilinoleyl diisostearate, dimer dilinoleyl hydrogenated rosin condensate, hydrogenated castor oil dimer dilinoleate, and hydroxyalkyl dimer dilinoleyl ether; coconut oil fatty acid monoethanolamide (cocamide ME Fatty acid alkanolamides such as coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethicone), Preferred examples include silicones such as propyl siloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, (aminoethyl aminopropyl methicone/dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphate-modified silicone, sulfate-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, amidoalkyl-modified silicone, aminoglycol-modified silicone, aminophenyl-modified silicone, and polysiloxane-oxyalkylene copolymer; and fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether.

Humectants and feel improvers include glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; water-soluble esters such as polyglyceryl-10 (eicosane diacid/tetradecanedioic acid), polyglyceryl-10 tetradecanedioate, and bisethoxydiglycol cyclohexanedicarboxylate; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylated and hydroxyalkylated), and β-cyclodextrins. -Sugars and derivatives thereof such as glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, caronin sulfate, keratosulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fructans such as inulin and levan; fucoidan; tuberose polysaccharide, naturally occurring polysaccharide; organic acids such as citric acid, tartaric acid, lactic acid and salts thereof; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salts, etc.; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine amino acids and salts thereof such as glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosine, and creatine; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen degradation peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degradation peptides, keratin degradation peptides, hydrolyzed keratin, conchiolin degradation peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolytic peptides, wheat proteolytic peptides, hydrolyzed wheat protein, casein degradation peptides, and acylated peptides. Preferred examples of such ingredients include protein peptides and their derivatives; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, and palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture medium, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, and whey; choline chloride, phosphorylcholine; animal and plant extracts such as aloe extract, witch hazel water, loofah water, chamomilla extract, licorice extract, comfrey extract, silk extract, rose rouge extract, yarrow extract, eucalyptus extract, and melilot extract; and ceramides such as natural ceramides (types 1, 2, 3, 4, 5, and 6), hydroxyceramides, pseudoceramides, glycosphingolipids, and extracts containing ceramides and glycoceramides.

Preferred surfactants include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants, polymer surfactants, etc. The HLB of the surfactant is not particularly limited, and surfactants from a low of about 1 to a high of about 20 can be used, and it is also preferable to combine surfactants with low and high HLBs. Preferred examples of surfactants include anionic surfactants such as fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate ester salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; and acyl N-methyl amino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosine, triethanolamine lauroyl sarcosine, and sodium lauroyl glutamate methyl alanine. Acylamino acid salts such as sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, triethanolamine cocoyl alanine, and sodium dilauroyl glutamate lysine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; fatty acid glycerides such as sodium hydrogenated coconut oil fatty acid glycerin sulfate alkyl benzene polyoxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, and sodium lauryl polypropylene glycol sulfosuccinate; alkyl benzene sulfonates such as sodium tetradecyl benzene sulfonate and triethanolamine tetradecyl benzene sulfonate; alkyl naphthalene sulfonates; alkanesulfonates; α-sulfofatty acid methyl ester salts; acyl isethiones acid salts; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; alkyl ether phosphate salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, and sodium monoolethphosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkylaryl ether phosphate salts; fatty acid amide ether phosphate salts; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid, and cyclic lysophosphatidic acid or salts thereof; silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; and nonionic surfactants such as laureth (polyoxyethylene lauryl ether). Polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers, such as polyoxyethylene alkyl ethers, ceteths (polyoxyethylene cetyl ethers), steareths (polyoxyethylene stearyl ethers), beheneths (polyoxyethylene behenyl ethers), isosteareths (polyoxyethylene isostearyl ethers), and octyldodeceths (polyoxyethylene octyldodecyl ethers); polyoxyethylene alkylphenyl ethers; polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, polyoxyethylene alkylphenyl ethers; Castor oil and hydrogenated castor oil derivatives such as diethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterols; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene-polyoxypropylene cetyl ether, polyoxyethylene-polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene-polyoxypropylene monobutyl ether, polyoxyethylene-polyoxypropylene hydrogenated lanolin, polyoxyethylene-polyoxypropylene glycerin ether and other polyoxyethylene-polyoxypropylene alkyl ethers; polyoxyethylene-polyoxypropylene glycol; PPG (Poly)glycerin polyoxypropylene glycol such as -9 diglyceryl; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, glycerin monocottonseed oil fatty acid, glycerin monoerucate, glycerin sesquioleate, glycerin α,α'-oleic acid pyroglutamate, glycerin monostearate malate, etc. glycerin fatty acid partial esters; polyglyceryl-2, 3, 4, 5, 6, 8, 10 stearate, polyglyceryl-6, 10 distearate, polyglyceryl-2 tristearate, polyglyceryl-10 decastearate, polyglyceryl-2, 3, 4, 5 isostearate , 6, 8, 10, Polyglyceryl-2 diisostearate (diglyceryl diisostearate), 3, 10, Polyglyceryl-2 triisostearate, Polyglyceryl-2 tetraisostearate, Polyglyceryl-10 decaisostearate, Polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 10, Polyglyceryl-6 dioleate, Polyglyceryl-2 trioleate, Polyglyceryl-10 decaoleate, and other polyglycerin fatty acid esters; ethylene glycol mono fatty acid esters such as ethylene glycol monostearate; propylene glycol mono fatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters esters; maltitol partial fatty acid esters; maltitol ethers; sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexanoate, and diglycerol sorbitan tetra-2-ethylhexanoate; partial esters of sugar derivatives such as sucrose fatty acid esters, methyl glucoside fatty acid esters, and trehalose undecylenate; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; glycolipids such as mannosyl erythritol lipid; lanolin alcohol; reduced lanolin; polyoxyethylene Polyoxyethylene fatty acid mono- and diesters such as diethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, and polyoxyethylene dioleate; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate Ethylene sorbitan fatty acid esters; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, selachyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene ethylene-tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amides; fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); lauramine oxide, cocamine oxide, stearamine oxide alkyldimethylamine oxides such as alkyl ethoxydimethylamine oxide, alkyl ethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; silicone-based nonionic surfactants such as polyether-modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerin-modified silicones, and sugar-modified silicones; cationic surfactants such as alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, and lauryltrimonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylamine oxides such as distearyldimonium chloride and dicocodimonium chloride; Ammonium chloride; fatty acid amidoamines and salts thereof such as stearamidopropyl dimethylamine and stearamidoethyl diethylamine; alkyl ether amines and salts or quaternary salts thereof such as stearoxypropyl dimethylamine; fatty acid amide quaternary ammonium salts such as long-chain branched fatty acid (12-31) aminopropylethyl dimethylammonium ethyl sulfate and lanolin fatty acid aminopropylethyl dimethylammonium ethyl sulfate; polyoxyethylene alkylamines and salts or quaternary salts thereof; alkylamine salts; fatty acid amide guanidinium salts; alkyl ether amine ammonium salts; alkyl trialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; polyamine fatty acid derivatives; silicone-based cationic surfactants such as amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, cation-modified and polyether-modified silicones, and amino-modified and polyether-modified silicones; amphoteric surfactants include N-alkyl-N,N-dimethyl amino acid betaines such as lauryl betaine (lauryl dimethyl amino acetate betaine); fatty acid amidoalkyl-N,N-dimethyl amino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyldimethyl betaines Preferred examples of the surfactant include alkyl sulfobetaines such as urin; sulfate type betaines such as alkyldimethylaminoethanol sulfate esters; phosphate type betaines such as alkyldimethylaminoethanol phosphate esters; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin; phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxide lecithin; silicone-based amphoteric surfactants; and polymer surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, gum tragacanth, and acrylic acid/alkyl methacrylate copolymers; and various silicone-based surfactants.

Polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcellaran, karaya gum, abelmoschus abies, carrageenan, tragacanth gum, pectin, pectinic acid and its salts such as sodium salt, alginic acid and its salts such as sodium salt, mannan; starches such as rice, corn, potato, and wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salts, xanthan gum, pullulan, and gellan gum. cellulose, chitin, chitosan, agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin; cellulose and its derivatives such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and its sodium salts, methylhydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethylammonium cellulose sulfate, crystalline cellulose, cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl cellulose, cellulose powder, cellulose derivatives, cellulose ester ... Starch-based polymers such as hydroxypropyl starch and methyl starch, starch derivatives such as hydroxypropyltrimonium starch chloride and corn starch aluminum octenylsuccinate; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinylpyrrolidone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate ester copolymers such as (methacryloyloxyethyl carboxybetaine/alkyl methacrylate) copolymer, (acrylates/stearyl acrylate/ethylamine oxide methacrylate) copolymer; (dimethicone/vinyl dimethicone) crosspolymer, (alkyl acrylate/diacetone acrylamide) copolymer, (alkyl acrylate/diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylamino methacrylate alkyl copolymers; acrylic resin alkanolamines; polyesters, water-dispersible polyesters; polyacrylamides; polyacrylic acid ester copolymers such as polyethyl acrylate, carboxyvinyl polymers, polyacrylic acid and its salts such as sodium salts, acrylic acid-methacrylic acid ester copolymers; acrylic acid-alkyl methacrylate copolymers; cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride-acrylamide copolymers such as polyquaternium-7, acrylic acid-diallyldimethylammonium chloride copolymers such as polyquaternium-22, acrylic acid-diallyldimethylammonium chloride-acrylamide copolymers such as polyquaternium-39, acrylic acid-cationized methacrylic acid ester copolymers, acrylic acid-cationized methacrylic acid amide copolymers, acrylic acid-methyl acrylate-methacrylamidopropyltrimethylammonium chloride copolymers such as polyquaternium-47, methacrylic acid chloride choline ester polymers; cationized oligosaccharides, cationized dextran, guar hydroxy Preferred examples include cationized polysaccharides such as propyltrimonium chloride; polyethyleneimine; cationic polymers; 2-methacryloyloxyethyl phosphorylcholine polymers such as polyquaternium-51 and copolymers with butyl methacrylate copolymers; polymer emulsions such as acrylic resin emulsions, polyethyl acrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone copolymers such as acrylic-silicone graft copolymers; various fluorine-containing polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride, fumed silica (ultrafine particle silicic anhydride), aluminum magnesium silicate, sodium magnesium silicate, metal soaps, dialkyl phosphate metal salts, bentonite, hectorite, organically modified clay minerals, sucrose fatty acid esters, and fructooligosaccharide fatty acid esters.

Preferred antioxidants include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate; BHT, BHA; gallic acid derivatives such as propyl gallate; vitamin C (ascorbic acid) and/or its derivatives; erythorbic acid and its derivatives; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, and cysteine hydrochloride. Preferred reducing agents include thioglycolic acid, cysteine, and cysteamine. Preferred oxidizing agents include hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate. Examples of antioxidants include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 3-O-ethyl ascorbic acid, 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside; ascorbic acid Preferred examples include ascorbic acid derivatives such as acid sulfate and tocopheryl ascorbyl phosphate; vitamin A compounds such as retinol, retinol acetate, retinol palmitate, and hydrogenated retinol; vitamin E compounds such as tocopherol, tocopherol acetate, and tocotrienol; carotenoids such as carotene, lycopene, astaxanthin, and lutein; polyphenols such as phlorotannin, curcumin, anthocyanin, proanthocyanin, catechin, ellagic acid, quercetin, and apple polyphenols; coenzyme Q10, lipoic acid, lactoferrin, sesamin, hesperidin, protoanthocyanidin, lignan, chlorogenic acid, rutin, fullerene, and platinum nanocolloid.

Skin whitening agents include hydroquinone glycosides and their esters, such as arbutin and α-arbutin; ascorbic acid, ascorbic acid phosphate salts, such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters, such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers, such as 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; Preferred examples include ascorbic acid glucoside and its fatty acid esters, such as ascorbic acid 2-glucoside; ascorbic acid derivatives, such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; tranexamic acid derivatives, such as tranexamic acid, cetyl tranexamate, and tranexamic acid amide; licorice extract-related substances, such as glabridin, glabrene, liquiritin, and isoliquiritin; and plant extracts, such as kojic acid, ellagic acid, ferulic acid and their derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomilla extract, oil-soluble licorice extract, Nishikawa willow extract, and saxifrage extract.

Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, and retinol palmitate; B vitamins such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, and choline; vitamin C such as ascorbic acid and its sodium salts; vitamin D; vitamin E such as α-, β-, γ-, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; vitamin B such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt. Preferred examples include ascorbic acid phosphate ester salts, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside, and ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate esters; tocotrienols; and various other vitamin derivatives.

Plant, animal and microbial extracts include iris extract, angelica extract, asparagus extract, avocado extract, hydrangea extract, almond extract, althea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, chinko extract, fennel extract, turmeric extract, oolong tea extract, uva ursi extract, angelica tree extract, echinacea leaf extract, emmeiso extract, scutellaria root extract, and ouba extract. Extract of kudzu, Coptis japonica extract, Barley extract, Panax ginseng extract, St. John's wort extract, Lamium extract, Ononis extract, Watercress extract, Orange extract, Dried seawater, Seaweed extract, Persimmon leaf extract, Kakyoku extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria lobata extract, Chamomilla extract, Oil-soluble Chamomilla extract, Carrot extract, Artemisia capillaris extract, Oat extract, Karcade extract, Licorice extract, Oil-soluble Licorice extract, kiwi extract, bell extract, wood ear extract, cinchona extract, cucumber extract, Paulownia leaf extract, guanosine, guava extract, kudzu root extract, gardenia extract, kumazasa extract, sophora extract, walnut extract, chestnut extract, grapefruit extract, clematis extract, black rice extract, brown sugar extract, black vinegar extract, chlorella extract, mulberry extract, gentian extract, geranium extract, black tea extract, yeast extract, magnolia bark extract , coffee extract, burdock extract, rice extract, fermented rice extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, bilberry extract, Chinese radish extract, Bupleurum extract, umbilical cord extract, saffron extract, salvia extract, soapwort extract, bamboo extract, hawthorn extract, Japanese sanshou extract, Japanese pepper extract, shiitake mushroom extract, rehmannia root extract, lithospermum root extract, perilla extract, linden extract, meadowsweet extract, jatoba extract, peony Yak extract, Angelica Root Extract, Calamus Root Extract, Birch Extract, White Fungus Extract, Horsetail Extract, Stevia Extract, Stevia Fermentation Product, Nishikawa Willow Extract, Ivy Extract, Hawthorn Extract, Elderberry Extract, Yarrow Extract, Peppermint Extract, Sage Extract, Mallow Extract, Cnidium Extract, Swertia Extract, Sophora Bark Extract, Rhubarb Extract, Soybean Extract, Chinese Soybean Extract, Thyme Extract, Poppopo extract, lichen extract, tea extract, clove extract, Imperata cylindrica extract, tangerine extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, Houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, burdock extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, burdock extract Preferred examples of extracts include okoshi extract, bisabolol, cypress extract, bifidobacterium extract, loquat extract, coltsfoot extract, butterbur stalk extract, poria cocos extract, butcher's broom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, myocarpus extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, lychee extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and burnet extract.

Examples of ultraviolet absorbers include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxypara-aminobenzoic acid ethyl ester, N,N-diethoxypara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid butyl ester, and N,N-dimethylpara-aminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid-based ultraviolet absorbers such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanolphenyl salicylate; octyl cinnamate, ethyl-4-isopropyl cinnamate, and methyl-2,5-diisopropyl Cinnamic acid-based UV absorbers such as pilcinnamate, ethyl 2,4-diisopropyl cinnamate, methyl 2,4-diisopropyl cinnamate, propyl p-methoxycinnamate, isopropyl p-methoxycinnamate, isoamyl p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl p-methoxycinnamate), 2-ethoxyethyl p-methoxycinnamate (cinoxate), cyclohexyl p-methoxycinnamate, ethyl α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocurine), glyceryl mono-2-ethylhexanoyl di-paramethoxycinnamate, ferulic acid and its derivatives; 2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethicone Benzophenone-based ultraviolet absorbers such as 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; Preferred examples include hydroxy-5'-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; hydantoin derivatives such as 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, and 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate; phenylbenzimidazolazole sulfonic acid, terephthalylidene dicamphorsulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and its derivatives, and oryzanol and its derivatives.

Antibacterial and preservative agents include parabens (hydroxybenzoic acid esters) such as methylparaben, ethylparaben, propylparaben, and butylparaben; phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; alkyl glyceryl ethers such as 2-ethylhexylglyceryl ether (ethylhexylglycerin); salicylic acid; lanolin fatty acids and their salts; sodium benzoate; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides, and quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, and benzalkonium chloride. Preferred examples of such antibacterial agents include methyl methyl ether, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, and hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, and sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolites, and silver ions. However, when used as an antibacterial agent or preservative for preservative purposes, from the standpoint of safety of cosmetics or topical skin preparations, it is more preferable to use phenoxyethanol; 1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol; and alkyl glyceryl ethers such as 2-ethylhexyl glyceryl ether.

Preferred examples of pH adjusters, acids, and alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, sodium hydroxide, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate.

Solvents and propellants include lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and diethylene glycol monoethyl ether. Preferred examples of propellants include glycol ethers such as propylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation chlorofluorocarbons; LPG, dimethyl ether, and carbon dioxide gas.

Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance P inhibitors. Examples of keratin exfoliants and dissolvers include salicylic acid, sulfur, resorcinol, selenium sulfide, pyridoxine, and glycolic acid. Examples of antiperspirants include aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate. Examples of cooling agents include menthol and methyl salicylate. Examples of astringents include citric acid, tartaric acid, lactic acid, aluminum potassium sulfate, tannic acid, and caffeine. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease. Preferred examples of nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

Preferred examples of anti-inflammatory agents include glycyrrhizinic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid and its derivatives, azelaic acid and its derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; and plant extracts such as peach leaf extract and mugwort leaf extract. Preferred examples of hair growth agents, blood circulation promoters, and stimulants include plant extracts and tinctures such as Swertia japonica extract, capsicum tincture, ginger tincture, ginger extract, and cantharis tincture; capsaicin, nonylic acid valenylamide, zingerone, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E, and derivatives thereof such as tocopherol nicotinate and tocopherol acetate, γ-oryzanol, nicotinic acid, and derivatives thereof such as nicotinamide, nicotinic acid benzyl ester, inositol hexanicotinate, and nicotine alcohol, allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavanonol derivatives, stigmasterol or stigmastanol and glycosides thereof, and minoxidil. Preferred hormones include estradiol, estrone, ethinylestradiol, cortisone, hydrocortisone, and prednisone.

Anti-wrinkle and anti-aging agents include ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as ascorbic acid monostearate, ascorbic acid monopalmitate, ascorbic acid dipalmitate, and ascorbic acid tetraisopalmitate; ascorbic acid ethers such as 2-O-ethyl ascorbic acid, cetyl ascorbic acid, glyceryl ascorbic acid, and hexylglyceryl ascorbic acid; ascorbic acid glucoside and its fatty acid esters such as ascorbic acid 2-glucoside; ascorbic acid derivatives such as ascorbic acid sulfate and tocopheryl ascorbyl phosphate; retinol, Preferred examples include vitamin A compounds such as retinol acetate, retinol palmitate, and hydrogenated retinol; nicotinamide, glutathione, cysteine, crocetin, sericin, geraniol, glycerin glucoside, lactoferrin, proanthocyanin, pantothenic acid, panthenol, soybean saponin, revelastol, isoflavones, coenzyme Q10, chondroitin sulfate, acetylglucosamine, glycerophosphatidylcholine, hydrolyzed hyaluronic acid, collagen peptide, conchiolin hydrolysate, adenosine 5'-monophosphate, phosphatidylinositol, trifluoroisopropyloxopropylaminocarbonylpyrrolidinecarbonylmethylpropylaminocarbonylbenzoylaminoacetic acid sodium, and tranexamic acid and derivatives thereof.

Preferred examples of irritation-reducing agents include mannosylerythritol lipid, dimer dilinoleic acid diethylene glycol oligomer ester, diisostearyl malate, N-acyl-L-glutamic acid, trehalose monofatty acid ester, fatty acid amidoamine oxide, alkyldimethylamine oxide, phenylethyl glucoside, lauryl glucoside, ferulic acid glucoside, salicin, cedrol, polyethylene glycol, and polypropylene glycol. Preferred examples of cooling agents include menthol, camphor, menthyl lactate, monomenthyl succinate, menthyl acetate, borneol, cineole, thymol, peppermint oil, and derivatives thereof. Preferred examples of warming agents include vanillin and its derivatives, nonanoic acid vanillylamide, shogaol, gingerol, capsicum tincture, capsicum extract, nicotinic acid derivatives such as benzyl nicotinate, methyl nicotinate, phenyl nicotinate, and tocopherol nicotinate, capsaicin, watercress extract, Japanese pepper extract, ginger extract, and canthari extract.

Powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, lepidolite, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, Prussian blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silicic anhydrous), titanium mica Preferred examples include inorganic powders of various sizes and shapes, such as fish scale foil, boron nitride, photochromic pigments, synthetic fluorine phlogopite, fine particle composite powder, gold, and aluminum, and inorganic powders obtained by treating these with silicones such as hydrogen silicone and cyclic hydrogen silicone, or other silanes, or various surface treatment agents such as titanium coupling agents to make them hydrophobic or hydrophilic; organic powders of various sizes and shapes, such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminated powder, polyethylene terephthalate-aluminum-epoxy laminated powder, urethane powder, silicone powder, and Teflon (registered trademark) powder, as well as surface-treated powders and organic-inorganic composite powders. Preferred examples of inorganic salts include sodium chloride-containing salts such as table salt, regular salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, and ammonium chloride; sodium sulfate, aluminum sulfate, aluminum-potassium sulfate (alum), aluminum-ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, and copper sulfate; sodium phosphates such as monosodium, disodium, and trisodium phosphate, potassium phosphates, calcium phosphates, and magnesium phosphates.

Dyes, colorants, dyes, and pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 3, Green 201, Green 202, Green 204, Green No. 205, Green No. 3, Green 401, and Green 402 No., Red No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 3, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223 , Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 40 No. 4, Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange 20 No. 5, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Legal dyes such as Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow No. 402, Yellow No. 403-1, Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Yellow No. 5; Acid Other acidic dyes such as Red 14; Basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N’-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue Nitro dyes such as 26; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red ochre) and iron titanate; inorganic brown pigments such as gamma-iron oxide; inorganic yellow pigments such as yellow iron oxide and ochre; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium dioxide-coated mica, titanium dioxide-coated bismuth oxychloride, titanium dioxide-coated talc, colored titanium dioxide-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; astaxanthin, aliza Preferred examples include natural pigments and dyes such as anthraquinones such as phosphorus, anthocyanidins, beta-carotene, catenal, capsanthin, chalcone, carthamine, quercetin, crocin, chlorophyll, curcumin, naphthoquinones such as cochineal and shikonin, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin; oxidation dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, and salts thereof; autoxidation dyes such as indoline; and dihydroxyacetone.

Fragrance ingredients: acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, beta-ionone, isoe super, isobutylquinoline, iris oil, iron, indole, ylang-ylang oil, undecanal, undecenal, gamma-undecalactone, estragole, eugenol, oakmoss, opoponax resinoid, orange oil, eugenol, auranthiol, galacsolids, carvacrol, L-carvone, camphor, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate , Geranyl acetate, Dimethylbenzylcarbinyl acetate, Styrallyl acetate, Cedryl acetate, Terpinel acetate, p-t-butylcyclohexyl acetate, Vetiveryl acetate, Benzyl acetate, Linalyl acetate, Isopentyl salicylate, Benzyl salicylate, Sandalwood oil, Santalol, Cyclamen aldehyde, Cyclopentadecanolide, Methyl dihydrojasmonate, Dihydromyrcenol, Jasmine absolute, Jasmine lactone, cis-Jasmone, Citral, Citronenol, Citronellal, Cinnamon bark oil, 1,8-cineole, Cinnamaldehyde, Su Chillax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, thymol, tuberose absolute, decanal, decalactone, terpineol, gamma-terpinene, triplal, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, alpha-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexyl cinnamaldehyde, cis-3-hexenoic acid Preferred examples include synthetic and natural fragrances such as balsam of Peru, vetiver oil, vetiverol, peppermint oil, pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, myrrh resinoid, musk ketone, methylnonylacetaldehyde, γ-methylionone, menthol, L-menthol, L-menthone, eucalyptus oil, β-ionone, lime oil, lavender oil, D-limonene, linalool, lyral, lilial, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, and various essential oils, as well as various blended fragrances.

Preferred water includes tap water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water.

In addition to these, it is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc. in known combinations, ratios, and amounts, such as ingredients listed in the Cosmetic Ingredient Standards, Cosmetic Type Ingredient Standards, Japan Cosmetic Industry Association Ingredient Labeling List, INCI Dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug Ingredient Standards, Japanese Pharmacopoeia, Pharmaceutical Additive Standards, Food Additives Standards, and ingredients listed in Japanese and foreign patent gazettes and patent publications (including published gazettes and republications) classified under the International Patent Classification IPC A61K7 and A61K8.

Types of cosmetics of the present invention include hair cosmetics, skin cosmetics, makeup cosmetics, fragrance cosmetics, and body cosmetics. The cosmetics of the present invention can be produced according to conventional methods.

To explain the types of cosmetics of the present invention in more detail, preferred examples of hair cosmetics include shampoos such as oil shampoo, cream shampoo, conditioning shampoo, anti-dandruff shampoo, hair color shampoo, and rinse-in-one shampoo; hair care agents such as rinse, conditioner, treatment, hair pack, hair mist, and hair oil; hair styling products such as hair foam, hair mousse, hair spray, hair wax, hair gel, hair cream, water grease, setting lotion, pomade, and tic; hair dyes such as color lotions, hair color treatments, hair manicures, and oxidation hair dyes; hair tonics, hair liquids, hair blow dryers, split end coats, permanent wave agents, straight perm agents, hair bleach, hair color pre-treatments, hair color after-treatments, perm pre-treatments, perm after-treatments, and hair growth agents.

Skin cosmetics include lotions such as softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, and liposome lotion; emulsions such as emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizing emulsion, massage lotion, exfoliating smoother, elbow lotion, hand lotion, and body lotion; emollient cream, nourishing cream, nourishing cream, vanishing cream, moisture cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, and shaving cream. Preferred examples include creams such as moisturizing cream and exfoliating cream; gels such as moisturizing gel, whitening gel and all-in-one gel; serums such as moisturizing essence, whitening essence, moisturizing serum and whitening serum; sunscreens such as sun protectant, sun protector, UV care milk and sunscreen; packs and masks such as peel-off packs, powder packs, washing packs, oil packs and cleansing masks; makeup removers such as cleansing foam, cleansing cream, cleansing milk, cleansing lotion, cleansing gel and cleansing oil; and facial cleansers such as paste facial cleanser, gel facial cleanser, foam facial cleanser, facial powder, cosmetic soap, transparent soap, medicated soap, liquid soap and shaving soap.

Preferred makeup cosmetics include lipstick, lip gloss, foundation, blush, face powder, concealer, eyeliner, mascara, eye shadow, eyebrow pencil, nail enamel, enamel remover, and nail treatment.

Preferred examples of aromatic cosmetics include perfumes, perfumes, parfums, eau de parfum, eau de toilette, eau de cologne, solid perfumes, aromatic powders, perfumed soaps, body lotions, and bath oils.

Preferred examples of body cosmetics include body cleansers such as body shampoos, deodorant cosmetics such as deodorant lotions, deodorant powders, deodorant sprays and deodorant sticks, bleaches, depilatories, bath additives, and insect repellents such as insect repellent sprays.

Preferred types of topical skin preparations of the present invention include ointments, lotions, creams, or gel-type skin preparations, patches, liniments, and liquid application preparations. They can also be used as oral cosmetics such as toothpastes and mouthwashes.

Preferred dosage forms of the cosmetic or topical skin preparation of the present invention include emulsion-type cosmetics such as oil-in-water (O/W) type, water-in-oil (W/O) type, W/O/W type, and O/W/O type, oil-based cosmetics, solid cosmetics, liquid cosmetics, paste cosmetics, stick-type cosmetics, volatile oil-type cosmetics, powder cosmetics, jelly-type cosmetics, gel-type cosmetics, paste-type cosmetics, emulsified polymer-type cosmetics, sheet-type cosmetics, mist-type cosmetics, and spray-type cosmetics.

The present invention will be explained in more detail by the following examples, but the present invention is not limited to these examples in any way.

Evaluation of Gel Cosmetics Gel cosmetics were prepared with the compositions shown in Tables 1 and 2 (Examples 1-2, Comparative Examples 1-7). The obtained gel cosmetics were evaluated for initial viscosity, viscosity stability (50°C/1 month), feel during use, and residual rate of 3-O-ethyl ascorbic acid (50°C/1 month). The evaluation methods are described below. The results are shown in Tables 1 and 2.

<Evaluation of viscosity stability>
The viscosity of the gel cosmetic was measured initially and after one month of storage at 50°C, and the rate of viscosity decrease after one month at 50°C relative to the initial viscosity was calculated (100 - viscosity after one month at 50°C ÷ initial viscosity × 100). The results were presented according to the following criteria based on the calculated rate of viscosity decrease. The viscosity was measured at 25°C using a B-type viscometer (manufactured by Toki Sangyo Co., Ltd.).

Judgment criteria Viscosity reduction rate is less than 20%: ○
Viscosity reduction rate is 20% or more but less than 50%: △
Viscosity reduction rate is 50% or more: ×

<Method for evaluating usability>
The two items of stickiness upon application and smoothness after drying were evaluated according to the following criteria. The results were expressed based on the average scores of five panelists and were rated according to the following criteria.

Evaluation criteria <Sticky feeling upon application>
Not at all: 5 points Not much: 4 points Normal: 3 points Somewhat: 2 points Very much: 1 point <Smooth feeling after drying>
Very sensitive: 5 points Slightly sensitive: 4 points Normal: 3 points Not very sensitive: 2 points Not sensitive at all: 1 point

Judgment criteria [Average score]: [Judgment]
4.5 or above: ◎
3.5 or more but less than 4.5: ○
1.5 or more to less than 3.5: △
Less than 1.5: ×

<Method for evaluating residual rate of 3-O-ethyl ascorbic acid>
The initial content of 3-O-ethylascorbic acid in the whitening gel and after storage at 50°C for one month were quantified by HPLC (column: octadecylsilylated silica gel column, eluent: 0.01 M aqueous sodium dihydrogen phosphate solution/acetonitrile=96/4, column temperature: 40°C, flow rate: 1 mL/min, detector: UV 245 nm), and the residual rate of 3-O-ethylascorbic acid after storage at 50°C for one month (content after storage at 50°C for one month/initial content×100) was calculated.

The results in Tables 1 and 2 show that Examples 1 and 2, which used component (A) of the present invention as a thickener, satisfied all of the requirements for thickening effect, viscosity stability, and usability, while Comparative Examples 1 to 7, which used other thickeners, did not satisfy all of these requirements. Furthermore, compared to Example 2, Example 1 had a transparent appearance, a very high residual rate of 3-O-ethylascorbic acid, and excellent stability of 3-O-ethylascorbic acid, demonstrating that phosphated cellulose nanofibers are more preferable as component (A) of the present invention.

Example 3: Lotion
Component Amount (mass%)
----------------------------------------------------------------------------------
A Division Aurovisco CS (Oji Holdings) 10.0
Tremoist-TP (Nippon Fine Chemical) 0.1
Sodium Hyaluronate 0.1
Purified water 20.0
Part B 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Nicotinamide 5.0
Ethanol 7.0
BG 7.0
Glycerin 5.0
Inulin-SC (Nippon Fine Chemical) 1.0
Neosolue-Aquilio (Nippon Fine Chemical) 1.0
Methylparaben 0.1
Phenoxyethanol 0.2
Citric acid 0.05
Sodium citrate (amount to make pH 4.5) pentasodium pentetate 0.10
Purified water Amount that makes a total of 100 -------------------------------------------------
(Preparation method)
Part A was stirred to form a viscous liquid. Part B was heated to about 70°C and dissolved uniformly. Part A was added to part B at about 50°C and stirred to dissolve uniformly.

Example 4 Lotion Ingredients Amount (mass%)
----------------------------------------------------------------------------------
Part A PrimeLipid PI (Nippon Fine Chemical) 0.25
BG 5.0
Dipropylene Glycol 3.0
1,2-Pentanediol 3.0
Part B Nicotinamide 1.0
Tranexamic acid (Nippon Fine Chemical) 1.0
Purified water 30.0
C Division Aurovisco CS (Oji Holdings) 10.0
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Neosolue-Aquilio (Nippon Fine Chemical) 1.0
Neosolue-Aqua (Nippon Fine Chemical) 1.0
Phytopresome MEL (Nippon Fine Chemical) 0.2
Dipotassium glycyrrhizinate 0.1
Inulin-SC (Nippon Fine Chemical) 0.1
Citric acid 0.1
Sodium citrate (amount to make the pH 4.5) pentasodium pentetate 0.05
Phytic acid 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Amount that makes a total of 100 -------------------------------------------------
(Preparation method)
Parts A and B were each heated to 70°C, and part A was added to part B while stirring with a homomixer (7000 rpm) to prepare a nanovesicle solution. After cooling, premixed part C was added to make a homogeneous solution.

Example 5: Lotion
Component Amount (wt%)
----------------------------------------------------------------------------------
Section A BG 5.0
Inositol 0.5
Glycyrrhizic acid 2K 0.01
Ethanol 3.0
Phenoxyethanol 0.2
Methylparaben 0.15
Citric acid 0.1
Sodium citrate: Amount to make the pH 4.5 Purified water: Amount to make the total 100: Part B Purified water: 5.0
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.5
C Division Aurovisco CS (Oji Holdings) 8.0
Carboxylated cellulose nanofiber (2% aqueous solution) 3.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was heated to about 80° C. and dissolved uniformly. After part A was cooled to 40° C., parts B and C were added to make a homogeneous liquid.

Example 6: Lotion
Component Amount (wt%)
----------------------------------------------------------------------------------
Section A BG 5.0
Neosolue-AquaS (Nippon Fine Chemical) 1.5
Ethanol 3.0
Phenoxyethanol 0.2
Methylparaben 0.15
Citric acid: Amount to make pH 4.5 Sodium citrate 0.1
Purified water Part B: Total 100 Purified water 5.0
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.5
C Division Aurovisco CS (Oji Holdings) 15.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was heated to about 80° C. and dissolved uniformly. After part A was cooled to 40° C., parts B and C were added to make a homogeneous liquid.

Example 7 Lotion
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Phytopresome (Nippon Fine Chemical) 0.2
BG 10.0
Part B Purified water 20.0
Part C 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Neosolue-Aquilio (Nippon Fine Chemical) 0.5
Succinic acid (appropriate amount) Sodium succinate 0.1
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water (amount D totaling 100) Aurovisco CS (Oji Holdings) 10.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was mixed and slowly added to part B while stirring. Parts C and D, which had been mixed in advance, were then added to make a homogeneous solution.

Example 8 Lotion
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Phytopresome MEL (Nippon Fine Chemical) 3.0
DPG 3.0
Glycerin 1.0
Part B Purified water 20.0
Part C 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.7
Neosolue-Aquilio (Nippon Fine Chemical) 0.5
Nicotinamide 0.3
Betaine 1.0
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water (amount D totaling 100) Aurovisco CS (Oji Holdings) 10.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was mixed and slowly added to part B while stirring. Parts C and D, which had been mixed in advance, were then added to make a homogeneous solution.

Example 9 Lotion
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Diglycerin 3.0
Hydrolyzed Hyaluronic Acid 0.01
Arginine 0.05
Neosolue-AquaS (Nippon Fine Chemical) 1.0
Betaine 0.5
Pullulan 0.5
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Part B: 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Aurovisco CS (Oji Holdings) 4.0
Carboxylated cellulose nanofiber (2% aqueous solution) 4.0
Sodium Hyaluronate 0.01
Purified water 10.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was heated to about 80°C and mixed uniformly. Part B was added to make a uniform liquid.

Example 10: Lotion
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Diglycerin 3.0
Neosolue-AquaS (Nippon Fine Chemical) 1.0
PEG/PPG/Polybutylene Glycol-8/5/3 Glycerin 0.5
Glucosylceramide 0.5
Glucosylrutin 0.01
Polyquaternium-51 0.5
Acetyl hexapeptide-8 0.001
Hydrolyzed Collagen 0.05
Arginine 0.05
Phenoxyethanol 0.2
Methylparaben 0.15
Xanthan gum 0.1
Purified water (amount totaling 100) Part B 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.3
Aurovisco CS (Oji Holdings) 5.0
Tremoist-TP (Nippon Fine Chemical) 0.01
Purified water 10.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was heated to about 80°C and mixed uniformly. Part B was added to make a uniform liquid.

Example 11 Gel lotion
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Phytocompo-PP (Nippon Fine Chemical) 1.0
Glycerin 5.0
Sorbitol solution (70%) 5.0
Glyceryl Behenate 0.8
Stearic acid 0.3
PEG-10 Dimethicone 0.4
Part B Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexylglycerin 0.2
PolyHEMA glucoside 0.05
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Sodium Hyaluronate 0.01
Purified water (amount C totaling 100) 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.05
Aurovisco CS (Oji Holdings) 40.0
Tremoist-TP (Nippon Fine Chemical) 0.1
Purified water 10.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was heated to about 70° C. and dispersed uniformly. Part B was added, stirred thoroughly, and homogenized, and then heated to about 70° C. Part B was added to Part A, and the mixture was stirred at about 70° C. using a homomixer, cooled to about 40° C., and Part C was added.

Example 12 Gel lotion
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Phytocompo-PP (Nippon Fine Chemical) 0.5
Glycerin 5.0
Sorbitol solution (70%) 5.0
Glyceryl Behenate 0.8
Stearic acid 0.3
PEG-20 hydrogenated castor oil 0.1
Polyglyceryl-10 Oleate 0.1
Part B Phenoxyethanol 0.3
Pullulan 0.2
Ethylhexylglycerin 0.2
Polymethacryloyl lysine 0.05
Crystalline cellulose powder 0.1
Locust bean gum 0.03
Hydroxyethyl cellulose 0.05
Sodium Hyaluronate 0.01
Carbomer 0.06
Potassium hydroxide 0.05
Purified water (total: 100) C parts 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.5
Aurovisco CS (Oji Holdings) 25.0
Carboxylated cellulose nanofiber (2% aqueous solution) 25.0
Tremoist-TP (Nippon Fine Chemical) 0.005
Purified water 10.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was heated to about 70°C and dispersed uniformly. Part B was mixed and stirred well to homogenize, and then heated to about 70°C. Part B was added to Part A, and the mixture was stirred at about 70°C using a homomixer and cooled to about 40°C. The mixed Part C was added and mixed uniformly.

Example 13 Transparent gel
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Glycerin 3.0
PEG-4000 0.2
Methylgluceth-10 1.0
Phenoxyethanol 0.3
Pyridoxine hydrochloride 0.05
Ethylhexylglycerin 0.2
Hydrolyzed Collagen 0.01
Purified water Part B (total: 100) Aurovisco CS (Oji Holdings) 20.0
Part C 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.9
Purified water 5.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was stirred to make a homogeneous solution, and parts B and C were added to part A and made homogeneous.

Example 14 Emulsion
Component Amount (mass%)
----------------------------------------------------------------------------------
Part A Sorbitan stearate 0.5
PEG-10 stearate 0.5
Polysorbate 60 0.5
Neosolue-DiSM (Nippon Fine Chemical) 1.0
Plandool-LG2 (Nippon Fine Chemical) 1.0
Plandooll-MAS (Nippon Fine Chemical) 1.0
Plandool-S (Nippon Fine Chemical) 1.0
Squalane 3.0
Polyglyceryl-2 Diisostearate 1.0
Jojoba oil 1.0
Ethylparaben 0.1
B Division Aurovisco CS (Oji Holdings) 10.0
(Acryloyldimethyltaurate ammonium/VP) copolymer 0.05
Purified water 20.0
Part C 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Tranexamic acid (Nippon Fine Chemical) 1.0
BG 5.0
Dipropylene Glycol 3.0
Neosolue-Aquilio (Nippon Fine Chemical) 1.0
Citric acid 0.07
Sodium citrate: Amount required to achieve a pH of 5.0 Phytic acid: 0.5
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Amount that makes a total of 100 -------------------------------------------------
(Preparation method)
Part A was heated to about 70°C and dissolved uniformly. Part B was stirred to form a viscous liquid. Part C was heated to about 70°C and dissolved uniformly. Part C was added to part A, emulsified using a homomixer, and then cooled. Part B was added at about 50°C and stirred to form a uniform liquid.

Example 15 Emulsion
Component Amount (mass%)
----------------------------------------------------------------------------------
Part A Phytocompo-C (Nippon Fine Chemical) 1.0
BG 10.0
Glycerin 9.0
Part B Bis-ethylhexyloxyphenol methoxyphenyl triazine
1.0
Diethylaminohydroxybenzoylhexyl benzoate 1.0
Ethylhexyl Triazone 1.0
Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemical) 2.0
Diethylhexyl sebacate (Nippon Fine Chemical) 3.0
Diethyl sebacate (Nippon Fine Chemical) 3.0
Diisopropyl sebacate (Nippon Fine Chemical) 6.0
Behenyl Alcohol 2.0
Plandooll-LG3 (Nippon Fine Chemical) 0.5
Plandool-SUN (Nippon Fine Chemical) 0.5
Plandool-ISS (Nippon Fine Chemical) 0.5
Part C 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Nicotinamide 1.0
Neosolue-Aquilio (Nippon Fine Chemical) 1.0
Neosolue-AquaS (Nippon Fine Chemical) 1.0
Citric acid 0.05
Sodium citrate (amount required to achieve a pH of 5.0) 0.05% pentasodium pentetate
Methylparaben (as needed) Purified water (total: 100) Part D Aurovisco CS (Oji Holdings) 10.0
Water-dispersible titanium dioxide 5.0
----------------------------------------------------------------------------------
(Preparation method)
Disperse part A uniformly. Heat and dissolve parts B and C separately at approximately 70°C. Add part B gradually to part A, then add part C gradually and emulsify. Cool with stirring, and add part D at 45°C and stir.

Example 16 Emulsion
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Diisostearyl malate 5.0
Plandool-DP (Nippon Fine Chemical) 1.0
Cetyl ethylhexanoate (Nippon Fine Chemical) 10.0
Cetyl alcohol 1.2
Phenyl Trimethicone 3.0
Ethylparaben 0.1
Myristyl Alcohol 2.0
Oleyl alcohol 1.0
B Division Aurovisco CS (Oji Holdings) 25.0
Carboxylated cellulose nanofiber (2% aqueous solution) 10.0
Stearoxyhydroxypropylmethylcellulose 0.1
Xanthan gum 0.1
Purified water 20.0
C part Phytocompo-PP (Nippon Fine Chemical) 1.0
Pentylene Glycol 3.0
Glycerin 8.0
Part D 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Purified water 20.0
Part E Phenoxyethanol 0.2
Methylparaben 0.15
Phytic acid 0.5
Succinic acid, appropriate amount Sodium succinate, appropriate amount Purified water Amount to make a total of 100
(Preparation method)
Parts A and E were each heated to about 70°C and uniformly dissolved. Part B was stirred to form a viscous liquid. Part C was heated to about 70°C and uniformly dispersed. Part A was added to part C while stirring with a homodisper, and then part E was added while stirring. Parts D and B were added at about 50°C and stirred to uniformly dissolve.

Example 17 Emulsion
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Phytocompo-C (Nippon Fine Chemical) 1.0
Hydrogenated lysolecithin (Nippon Fine Chemical) 0.1
Part B Mineral oil 5.0
Triethylhexanoin (Nippon Fine Chemical) 3.0
LUSPLAN SR-DM4 (Nippon Fine Chemical) 0.5
Hydrogenated polyisobutene 3.5
Isododecane 1.5
Cetostearyl Alcohol 1.0
Arachyl alcohol 0.1
Jojoba Alcohol 3.0
Chimyl alcohol 0.3
Selachyl alcohol 0.1
Hexyldecanol 0.5
Part C (hydroxyethyl acrylate/sodium acryloyldimethyltaurate) copolymer
0.2
Purified water 20.0
D part Neosolue-AquaS (Nippon Fine Chemical) 0.5
Polyquaternium-51 1.0
Ascorbyl Glucoside 1.0
Potassium hydroxide 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water (total: 100) E parts 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.1
Carboxylated cellulose nanofiber (2% aqueous solution) 25.0
Carbomer 0.15
Potassium hydroxide 0.06
Tremoist-TP (Nippon Fine Chemical) 0.1
Purified water 10.0
----------------------------------------------------------------------------------
(Preparation method)
Parts A, B, and D were mixed and heated to about 70°C to dissolve and disperse uniformly. Part C was mixed and stirred to form a viscous liquid. Part B was added to Part A while stirring with a homodisper, and then Part D was added to emulsify. The mixture was cooled, and at about 50°C, parts C and E were added, and the mixture was stirred and cooled to about 40°C.

Example 18 Emulsion
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Diisostearyl Malate 5.0
Plandool-DP (Nippon Fine Chemical) 1.0
Cetyl ethylhexanoate (Nippon Fine Chemical) 10.0
Cetyl alcohol 1.2
Phenyl Trimethicone 3.0
Ethylparaben 0.1
Myristyl Alcohol 2.0
Oleyl alcohol 1.0
B Division Aurovisco CS (Oji Holdings) 10.0
Stearoxyhydroxypropylmethylcellulose 0.1
Xanthan gum 0.1
Purified water 20.0
C part Phytocompo-PP (Nippon Fine Chemical) 1.0
Pentylene Glycol 3.0
Glycerin 8.0
Part D 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.5
Purified water 5.0
Part E Phenoxyethanol 0.2
Methylparaben 0.15
Phytic acid 0.5
Citric acid, appropriate amount Sodium citrate, appropriate amount Purified water Amount to make a total of 100
(Preparation method)
Parts A and E were each heated to about 70°C and uniformly dissolved. Part B was stirred to form a viscous liquid. Part C was heated to about 70°C and uniformly dispersed. Part A was added to part C while stirring with a homodisper, and then part E was added while stirring. Parts D and B were added at about 50°C and stirred to uniformly dissolve.

Example 19 Emulsion
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Glycerin 3.0
Diglycerin 1.0
BG 7.0
Phytocompo-C (Nippon Fine Chemical) 1.0
Hydrogenated lysolecithin (Nippon Fine Chemical) 0.1
Part B Mineral oil 5.0
Triethylhexanoin (Nippon Fine Chemical) 3.0
LUSPLAN SR-DM4 (Nippon Fine Chemical) 0.5
Hydrogenated polyisobutene 3.5
Isododecane 1.5
Cetostearyl Alcohol 1.0
Arachyl alcohol 0.1
Jojoba Alcohol 3.0
Chimyl alcohol 0.3
Selachyl alcohol 0.1
Hexyldecanol 0.5
Part C (hydroxyethyl acrylate/sodium acryloyldimethyltaurate) copolymer
0.2
Purified water 20.0
D part Neosolue-AquaS (Nippon Fine Chemical) 0.5
Polyquaternium-51 1.0
Tranexamic acid 1.0
Potassium hydroxide 0.2
Phenoxyethanol 0.2
Methylparaben 0.15
Purified water (total: 100) E parts 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.8
Aurovisco CS (Oji Holdings) 1.0
Tremoist-TP (Nippon Fine Chemical) 0.1
Ethanol 10.0
Purified water 10.0
----------------------------------------------------------------------------------
(Preparation method)
Parts A, B, and D were mixed and heated to about 70°C to dissolve and disperse uniformly. Part C was mixed and stirred to form a viscous liquid. Part B was added to Part A while stirring with a homodisper, and then Part D was added to emulsify. The mixture was cooled, and at about 50°C, parts C and E were added, and the mixture was stirred and cooled to about 40°C.

Example 20 Emulsion
Component Amount (wt%)
------------------------------------------------------------------
Part A Phytocompo-SP (Nippon Fine Chemical) 8.0
Hydrogenated lysophospholipid (Nippon Fine Chemical) 0.1
Part B LUSPLAN SR-DM4 (Nippon Fine Chemical) 5.0
Squalane 4.0
Caprylic/capric triglyceride (Nippon Fine Chemical) 4.0
α-olefin oligomer 2.5
Cyclopentasiloxane 3.5
Cetyl alcohol 1.5
Glyceryl stearate 1.0
C part DPG 5.0
Hydroxyproline 0.05
Citric acid 0.01
Sodium citrate 0.09
Phenoxyethanol 0.3
Methylparaben 0.1
Acrylic acid/alkyl methacrylate copolymer 0.1
Potassium hydroxide 0.1
Purified water (total: 100) D parts 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.5
Aurovisco CS (Oji Holdings) 15.0
Tremoist-TP (Nippon Fine Chemical) 0.01
Purified water 10.0
----------------------------------------------------------------------------------
(Preparation method)
Parts A to C were each taken, heated to about 70°C, and mixed uniformly. Part B was gradually added to Part A while stirring with a homodisper, and then Part C was added at about 70°C to emulsify. After cooling to about 40°C, the mixed Part D was added and mixed uniformly.

Example 21 Cream
Component Amount (mass%)
----------------------------------------------------------------------------------
Part A Plandool-LG1 (Nippon Fine Chemical) 0.5
Plandooll-MAS (Nippon Fine Chemical) 0.5
Plandool-H (Nippon Fine Chemical) 0.5
Plandool-G (Nippon Fine Chemical) 0.5
LUSPLAN PI-DA (Nippon Fine Chemical) 0.5
Diethylhexyl succinate (Nippon Fine Chemical) 3.0
Behenyl Alcohol 2.0
Stearyl alcohol 1.2
Glyceryl Stearate 1.5
Polyglyceryl-10 Isostearate 1.5
Ethylparaben 0.1
B Division Aurovisco CS (Oji Holdings) 10.0
Carboxylated cellulose nanofiber (2% aqueous solution) 10.0
Part C 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Arbutin (Nippon Fine Chemical) 1.0
Nicotinamide 1.0
Purified water 10.0
Part D 1,3-butylene glycol 5.0
Glycerin 3.0
Neosolue-Aquilio (Nippon Fine Chemical) 0.5
Etidronic acid 0.05
Sodium pyrosulfite 0.05
Citric acid 0.05
Sodium citrate (enough to bring the pH to 5.0) Phenoxyethanol 0.2
Methylparaben 0.15
Purified water Amount that makes a total of 100 -------------------------------------------------
(Preparation method)
Part A was mixed and heated to about 70°C and dissolved uniformly. Part C was mixed and dissolved uniformly. Part D was mixed and heated to about 70°C and dissolved uniformly. Part D was added to part A and emulsified using a homomixer, then cooled to about 50°C, and parts B and C were added and stirred to obtain a uniform liquid.

Example 22 Cream
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Mineral oil 7.8
Vaseline 7.0
Squalane 0.2
Jojoba oil 0.15
Microcrystalline Wax 2.4
Paraffin Wax 2.0
Aluminum distearate 0.9
Hydrogenated polyisobutene 2.8
Lanolin alcohol (Nippon Fine Chemical) 2.3
Octyldodecanol 3.0
Part B Mg sulfate 0.5
Sodium benzoate 0.1
Concentrated glycerin 3.5
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.5
Aurovisco CS (Oji Holdings) 13.0
Purified water (total: 100) Part C Magnesium stearate 0.9
Cyclomethicone 2.5
----------------------------------------------------------------------------------
(Preparation method)
Parts A and B were heated to dissolve and uniformly dispersed. Part B was gradually added to Part A to emulsify, and the dispersed Part C was added and cooled with stirring. Part C was added at approximately 40°C and mixed uniformly.

Example 23 Skin Care Cream
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Glycerin 9.0
DPG 5.0
Phytocompo-PP (Nippon Fine Chemical) 1.0
Part B Mineral oil 8.0
Vaseline 10.0
Pentaerythrityl tetraisostearate 5.0
Astaxanthin 0.01
Cetyl PG Hydroxyethyl Palmitamide 0.05
Sodium cyclic lysophosphatidic acid 0.01
Dipentaerythrityl hexahydroxystearate 1.0
Part C Carbomer 0.1
Potassium hydroxide 0.07
Xanthan gum 0.1
Purified water 10.0
Part D Phenoxyethanol 0.4
Ethylhexylglycerin 0.2
Methylparaben 0.05
Purified water (total: 100) E parts 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.7
Aurovisco CS (Oji Holdings) 4.0
----------------------------------------------------------------------------------
(Preparation method)
Parts A, B, and D were mixed and heated to about 70°C to dissolve and disperse uniformly. Part C was mixed and stirred to form a viscous liquid. Part B was added to Part A while stirring with a homodisper, and then Part D was added to emulsify. The mixture was cooled, and at about 50°C, parts C and E were added, and the mixture was stirred and cooled to about 40°C.

Example 24 Skin Care Cream
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Squalane 10.0
Stearic Acid 1.0
Plandool-ISS (Nippon Fine Chemical) 1.0
Macadamia nut oil 3.0
Hydrogenated rapeseed oil alcohol 2.0
Olive oil fatty acid cetearyl 1.0
Sorbitan olive oil fatty acids 0.8
Polyglyceryl-10 Oleate 1.0
B Division Aurovisco CS (Oji Holdings) 18.0
Acrylic acid/alkyl methacrylate copolymer 0.1
Potassium hydroxide 0.07
(Acryloyldimethyltaurate ammonium/
Beheneth-25 Methacrylate Crosspolymer 0.2
Purified water 10.0
Hydrolyzed poly-γ-glutamic acid potassium 0.1
Sodium polyglutamate 0.1
Oligopeptide-24 0.05
Part C Glycerin 9.0
Propanediol 10.0
PEG-8 5.0
Methylparaben 0.1
Phenoxyethanol 0.3
Purified water (total: 100) D parts 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Tremoist-TP (Nippon Fine Chemical) 0.05
Purified water 10.0
----------------------------------------------------------------------------------
(Preparation method)
Parts A and C were mixed and heated to about 70°C to dissolve and disperse uniformly. Part B was mixed and stirred to form a viscous liquid. Part D was mixed to form a uniform liquid. Part A was added to part C while stirring with a homomixer to emulsify. After cooling to about 50°C, parts B and D were added, stirred, and cooled to about 40°C.

Example 25 Skin Care Cream
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Mineral oil 8.0
Plandoor-MAS (Nippon Fine Chemical) 2.0
Plandoool-LG1 (Nippon Fine Chemical) 1.0
Paraffin Wax 3.0
Shea Butter 3.0
Squalane 8.0
Cetyl alcohol 1.8
Hydrogenated Cocoglycerides 0.8
Glyceryl stearate 1.0
Behenyl Alcohol 1.5
Sorbitan stearate 1.0
Methyl glucose sesquistearate 1.5
B Division Aurovisco CS (Oji Holdings) 30.0
Xanthan gum 0.1
Hydroxyethyl cellulose 0.1
Crystalline cellulose powder 0.3
Stearoxyhydroxypropylmethylcellulose 0.1
Purified water 20.0
Part C Glycerin 8.0
DPG 5.0
Sorbitol 2.0
Methylparaben 0.15
Purified water (total: 100) D parts 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Tremoist-TP (Nippon Fine Chemical) 0.1
Purified water 10.0
----------------------------------------------------------------------------------
(Preparation method)
Parts A and C were mixed and heated to about 70°C to dissolve and disperse uniformly. Part B was mixed and stirred to form a viscous liquid. Part D was mixed to form a uniform liquid. Part A was added to part C while stirring with a homomixer to emulsify. After cooling to about 50°C, parts B and D were added, stirred, and cooled to about 40°C.

Example 26 Skin Care Cream
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Glycerin 9.0
Phytocompo-C (Nippon Fine Chemical) 1.0
Glucosylrutin 0.001
Part B Argania spinosa kernel oil 1.0
Theobroma grandiflorum seed oil 1.0
Astaxanthin 0.005
Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemical) 0.5
Ethylhexyl stearate 3.0
Plandool-ISS (Nippon Fine Chemical) 2.0
Carnauba wax 0.5
Steareth-2 2.5
Steareth-21 1.8
Cetyl alcohol 3.0
Tocopheryl acetate 0.03
Squalane 6.0
Part C Carbomer 0.1
Aurovisco CS (Oji Holdings) 4.0
Arginine 0.1
Hydroxypropyl chitosan 0.2
Ethanol 3.0
Purified water 10.0
Panthenol 0.5
Retinol Palmitate 0.05
Part D Methylparaben 0.15
Purified water (total: 100) E parts 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.5
Purified water 5.0
----------------------------------------------------------------------------------
(Preparation method)
Parts A, B, and D were mixed and heated to about 70°C, and uniformly dissolved and dispersed. Part C was mixed and stirred to form a viscous liquid. Part B was added to Part A while stirring with a homodisper, and then Part D was added and emulsified. After cooling to about 50°C, parts C and E were added, and the mixture was stirred and cooled to about 40°C.

Example 27 Skin Care Cream
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Glycerin 12.0
BG 6.0
Phytocompo-PP (Nippon Fine Chemical) 2.5
Part B Mineral oil 3.0
Olive Fruit Oil 3.0
1.5 tablespoons olive oil
Shea butter 1.0
Plandool-S (Nippon Fine Chemical) 1.0
Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemical) 3.0
Sucrose stearate 0.8
Cetearyl Glucoside 1.2
Behenyl Alcohol 1.5
Ascorbyl Tetrahexyldecanoate 7.0
Isopropyl Lauroyl Sarcosinate 2.0
Hydrogenated Cocoglycerides 3.0
Cetyl alcohol 2.5
Sorbitan stearate 0.8
Part C Xanthan gum 0.05
Tuberose polysaccharide 0.01
Water-soluble collagen 0.05
Hydrolyzed Collagen 0.5
Sodium pyrosulfite 0.03
D part Neosolue-Aqulio (Nippon Fine Chemical) 1.0
Propanediol 3.0
Methylparaben 0.1
Purified water (total: 100) E parts 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.4
Aurovisco CS (Oji Holdings) 10.0
Tremoist-TP (Nippon Fine Chemical) 0.02
Purified water 10.0
----------------------------------------------------------------------------------
(Preparation method)
Parts A, B, and D were mixed and heated to about 70°C, and uniformly dissolved and dispersed. Part C was mixed and stirred to form a viscous liquid. Part E was mixed to form a uniform liquid. Part B was added to part A while stirring with a homodisper, and then part D was added and emulsified. After cooling to about 50°C, parts C and E were added, and the mixture was stirred and cooled to about 40°C.

Example 28 Hand Cream
Component Amount (wt%)
------------------------------------------------------------------
Part A Diisostearyl malate 8.0
Lanolin fatty acid cholesteryl (Nippon Fine Chemical) 5.0
LUSPLAN SR-DM4 (Nippon Fine Chemical) 0.1
Squalane 8.0
Macadamia nut oil 0.5
Rosehip Oil 1.0
Meadowfoam Oil 1.0
Vaseline 15.0
Microcrystalline Wax 2.0
Glyceryl Stearate 2.0
Cetyl alcohol 2.0
Cetyl Phosphate 1.0
Beeswax 3.0
Propylparaben 0.1
Tocopherol 0.05
Perfluoropolyether 1.0
Part B Glycerin 8.0
1,2-Hexanediol 3.0
Methylparaben 0.1
Ethylhexylglycerin 0.5
Phenoxyethanol 0.3
Citric acid 0.10
Sodium citrate (enough to make the pH 4.5) Water (enough to make the total 100) Part C 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.8
Aurovisco CS (Oji Holdings) 15.0
------------------------------------------------------------------
(Preparation method)
Part B was heated to about 70°C and dissolved. Part A was placed in a separate container and heated to about 80°C and dissolved. Part A was added to part B while stirring with a homomixer to emulsify. After emulsification, the mixture was cooled to about 40°C, and then part C was added and mixed uniformly.

Example 29 Hand Cream
Component Amount (weight%)
------------------------------------------------------------------
Part A Vaseline 5.0
Plandool-G (Nippon Fine Chemical) 0.5
(Dimethicone/vinyl dimethicone) crosspolymer 0.3
(Vinyl dimethicone/lauryl dimethicone) crosspolymer 0.5
(Dimethicone/PEG-10/15) Crosspolymer 0.5
(PEG-15/Lauryl Dimethicone) Crosspolymer 0.2
(Alkyl acrylate/dimethicone) copolymer 0.1
Cetyl ethylhexanoate (Nippon Fine Chemical) 10.0
Propylparaben 0.1
Squalane 5.0
Part B Diglycerin 5.0
Methylparaben 0.1
Part C Xanthan gum (2% aqueous solution) 2.0
Aurovisco CS (Oji Holdings) 10.0
(Acrylamide/ammonium acrylate) copolymer 0.5
Water (amount D to make a total of 100) 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Purified water 5.0
------------------------------------------------------------------
(Preparation method)
After dissolving part B, part A was added and heated to about 70°C (part E). Part C was heated to about 70°C. Part C was added to part E while stirring, and the mixture was stirred and mixed with a homomixer for about 3 minutes. After cooling to about 40°C, the mixed part D was added and mixed uniformly.

Example 30 Hand Cream
Component Amount (wt%)
------------------------------------------------------------------
Part A Squalane 10.0
Vaseline 20.0
Polyglyceryl-10 Pentastearate 2.0
Microcrystalline Wax 4.0
Sodium stearoyl lactylate 1.3
Aluminum stearate 1.5
Magnesium stearate 1.0
Calcium stearate 0.1
Part B LUSPLAN PI-DA (Nippon Fine Chemical) 5.0
Plandooll-MAS (Nippon Fine Chemical) 1.0
Plandool-DP (Nippon Fine Chemical) 0.8
Cetyl ethylhexanoate (Nippon Fine Chemical) 5.0
Triethylhexanoin (Nippon Fine Chemical) 6.0
Propylparaben 0.05
Tocopherol 0.05
Cyclopentasiloxane 5.0
Part C Methylparaben 0.1
Aurovisco CS (Oji Holdings) 10.0
Glycerin 10.0
Water (amount D to make a total of 100) 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.6
Purified water 10.0
------------------------------------------------------------------
(Preparation method)
Parts B and C were heated to about 80°C and dissolved. Part A was placed in a separate container and heated to 100-120°C until it became a transparent gel, which was then cooled to 80°C. Part B was added to part A while stirring, and then part C was added and emulsified. After cooling to about 40°C, the mixed part D was added and mixed uniformly.

Example 31
eye cream
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Squalane 5.0
Diethylhexyl succinate (Nippon Fine Chemical) 1.0
LUSPLAN PI-DA (Nippon Fine Chemical) 0.5
Vaseline 2.0
Plandool-MAS (Nippon Fine Chemical) 3.0
Behenyl Alcohol 2.0
Cetearyl Alcohol 5.0
Beeswax 0.7
Polyglyceryl-10 stearate 0.7
Polyglyceryl-10 Oleate 0.3
Glyceryl stearate (SE) 1.0
Tocopherol 0.1
Glycerin 3.0
BG 5.0
Part B Citric acid 0.1
Sodium citrate pH adjusted to 4.5 Phenoxyethanol 0.4
EDTA-2Na 0.05
Purified water (amount C) totaling 100 Aurovisco CS (Oji Holdings) 20.0
Xanthan gum 0.2
Dimethicone 0.5
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 1.0
----------------------------------------------------------------------------------
(Preparation method)
Parts A and B were mixed and heated to about 70°C to dissolve and disperse uniformly. Part C was mixed and stirred to form a viscous liquid. Part B was added to Part A while stirring with a homodisper. After cooling, Part C was added and mixed uniformly.

Example 32 Cleansing Gel
Component Amount (weight%)
------------------------------------------------------------------
Part A Cetyl ethylhexanoate (Nippon Fine Chemical) 10.0
Plandool-S (Nippon Fine Chemical) 1.0
Dihydrocholesterol-3 (Nippon Fine Chemical) 2.0
LUSPLAN DD-IS (Nippon Fine Chemical) 8.0
PEG-25 hydrogenated castor oil 20.0
Octyldodeceth-20 15.0
Glycerin 16.0
BG 5.0
Part B Phenoxyethanol 0.5
Purified water (amount C) totaling 100 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.5
Aurovisco CS (Oji Holdings) 4.0
------------------------------------------------------------------
(Preparation method)
Part A and Part B were each heated to about 80°C and dissolved. The mixture was mixed and heated to about 80°C. Part B was gradually added to Part A while stirring, and after mixing, the mixture was cooled to 40°C. Part C was added and mixed uniformly.

Example 33 Cleansing Cream
Component Amount (wt%)
------------------------------------------------------------------
Part A Neosolue-DE (Nippon Fine Chemical) 5.0
Glycerin 3.0
Plandool-LG2 (Nippon Fine Chemical) 1.0
Neosolue-Aquilio (Nippon Fine Chemical) 1.0
Ceresin 6.0
Mineral oil 28.0
PEG-12 Isostearate 3.0
Sorbitan Sesquioleate 1.5
Polyoxyethylene sorbitan oleate 0.3
Microcrystalline Wax 2.0
Tocopherol 0.05
Propylparaben 0.05
Part B DPG 5.0
Aurovisco CS (Oji Holdings) 40.0
Methylparaben 0.2
Disodium edetate 0.02
Phenoxyethanol 0.2
Purified water (total: 100) C parts 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.4
Purified water 10.0
------------------------------------------------------------------
(Preparation method)
Part A and Part B were each heated to about 80°C and dissolved. The mixture was mixed and heated to about 80°C. Part B was gradually added to Part A while stirring, and after mixing, the mixture was cooled to 40°C. Part C was added and mixed uniformly.

Example 34 Facial cleanser
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Potassium stearate 10.0
Potassium palmitate 10.0
Potassium myristate 10.0
Potassium laurate 4.0
Isopropyl Lauroyl Sarcosinate 0.8
PEG1500 10.0
Glycerin 15.0
Glyceryl Monostearate 1.0
POE (20) Sorbitan Monostearate 2.0
Part B Polyquaternium-7 0.5
Polyquaternium-39 0.5
Methylparaben 0.1
Purified water (amount C totaling 100) 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Aurovisco CS (Oji Holdings) 20.0
Carboxylated cellulose nanofiber (2% aqueous solution) 3.0
Purified water 5.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was heated to about 80° C. and dissolved. Part B was heated to about 80° C. Part B was gradually added to part A while stirring, and after mixing, the mixture was cooled to 40° C. Part C was added and mixed uniformly.

Example 35 Facial cleanser
Component Amount (wt%)
------------------------------------------------------------------
Part A (coconut fatty acid/hydrogenated beef tallow fatty acid) sodium glutamate 30.0
Potassium Cocoyl Glycine 5.0
Coconut oil alkyl glucoside 1.0
Plandooll-LG2 (Nippon Fine Chemical) 0.2
Lauric acid diethanolamide 3.0
Tocopherol 0.1
PEG-8 5.0
Glycerin 14.0
Propylparaben 0.1
Part B Methylparaben 0.2
Polyquaternium-51 1.0
Microcrystalline cellulose 0.3
Polyquaternium-7 0.8
Purified water (amount C totaling 100) 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.9
Aurovisco CS (Oji Holdings) 10.0
Tremoist-TP (Nippon Fine Chemical) 0.02
Purified water 10.0
------------------------------------------------------------------
(Preparation method)
Part A was heated to about 80° C. and dissolved. Part B was heated to about 80° C. Part B was gradually added to Part A while stirring, and after mixing, the mixture was cooled to 40° C. Part C was added and mixed uniformly.

Example 36 Facial cleansing powder
Component Amount (wt%)
------------------------------------------------------------------
Part A Cornstarch Amount that makes the total 100 Potassium myristate 10.0
Sorbitol 5.0
Inulin-SC 3.0
Sodium Cocoyl Glycinate 3.0
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.05
Aurovisco CS (Oji Holdings) 1.0
BG 0.5
Silica 1.0
------------------------------------------------------------------
(Preparation method)
Part A was mixed uniformly.

Example 37 Non-silicone shampoo
Component Amount (wt%)
------------------------------------------------------------------
Plandool-LG2 (Nippon Fine Chemical) 0.03
Diethylhexyl succinate (Nippon Fine Chemical) 0.01
Neosolue-AquaS (Nippon Fine Chemical) 0.1
Tremoist-SL (Nippon Fine Chemical) 0.5
Sodium Laureth-4 Carboxylate (28%) 10.0
Laureth-6 Carboxylic Acid 4.0
Cocamidopropyl Betaine (30%) 10.0
Sodium Lauroyl Methylalanine (30%) 5.0
Cocamidomethyl MEA 3.0
PEG-7 Glyceryl Cocoate 5.0
Sodium hydroxide 1% solution 0.5
Polyquaternium-10 0.8
Glycol distearate 0.5
Polyquaternium-7 0.5
EDTA-2Na 0.05
1,2-Pentanediol 5.0
Phenoxyethanol 0.4
Sodium benzoate 0.2
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.2
Aurovisco CS (Oji Holdings) 15.0
Purified water Amount that makes a total of 100 ---------------------------------
(Preparation method)
All ingredients were heated to about 80°C and mixed uniformly with stirring.

Example 38 Leave-in hair treatment
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Polyquaternium-37 2.0
Squalane 2.0
PPG-3 Caprylyl Ether 2.0
Microcrystalline wax 0.1
Lanolin alcohol 0.2
Sunflower Seed Wax 0.1
Polyethylene wax 0.1
Rowlet 0.2
Ceresin 0.1
Dicapric Acid PG 1.0
Almond oil 0.5
Ethylhexyl ethylhexanoate 1.0
Candelilla wax extract 0.1
Octyldodecyl erucate 4.5
Plandool-DP (Nippon Fine Chemical) 0.2
Tocopheryl acetate 0.02
Erucalactone MCT (Nippon Fine Chemical) 2.0
Dipentaerythrityl Tri-Polyhydroxystearate 1.5
PPG-5 Phytosteryl 0.5
1,2-Pentanediol 5.0
Glycerin 4.0
Sorbitol 2.0
Phenoxyethanol 0.5
Part B Hydrolyzed hyaluronic acid 0.1
Panthenol 0.1
Hyaluronic acid hydroxypropyltrimonium 0.01
Polyquaternium-11 0.2
Glycosyltrehalose 0.1
Glyceryl glucoside 0.3
Arginine 0.1
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.1
Aurovisco CS (Oji Holdings) 4.0
Part C Purified water Amount to make a total of 100 Hydroxypropyl starch phosphate 1.0
----------------------------------------------------------------------------------
(Preparation method)
Part C was uniformly dispersed and heated to about 80° C. Next, part A was heated to about 80° C. and dissolved. Part A was added to part C while stirring, and after uniform mixing, the mixture was cooled to about 40° C. Next, part B was added and mixed uniformly.

Example 39: Non-silicone hair treatment
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Plandool-LG2 (Nippon Fine Chemical) 0.5
Propanediol 3.0
Behenamidopropyl dimethylamine 1.5
Cetyl alcohol 2.2
Stearyl alcohol 0.8
Hydrogenated rapeseed oil alcohol 0.5
Neopentyl glycol diethylhexanoate 0.8
Jojoba Seed Oil 1.0
Isododecane 1.0
Glyceryl stearate 0.4
Propylparaben 0.1
Cocamidomethyl MEA 0.8
Caesalpinia spinosa Hydroxypropyltrimonium chloride 0.1
Rice bran wax 0.5
Erucalactone DES (Nippon Fine Chemical) 2.0
Glycerin 1.0
Part B 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Phosphatidylinositol 0.05
Hydrogenated lecithin 0.1
1,2-Pentanediol 3.0
Purified water 20.0
Part C Phenoxyethanol 0.4
Tremoist-SL (Nippon Fine Chemical) 1.0
Lactic acid 0.4
Aurovisco CS (Oji Holdings) 15.0
Purified water Amount that makes a total of 100 -------------------------------------------------
(Preparation method)
Parts A and C were mixed uniformly at about 80°C. Part B was dispersed uniformly at about 70°C. Part C was gradually added to part A while stirring, and after uniform mixing, the mixture was cooled to about 50°C. Part B was added and mixed uniformly.

Example 40 Dandruff shampoo
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A PPG-3 Caprylyl Ether 0.2
Sodium Lauroyl Methylalanine (30%) 13.0
Cocamidopropyl Betaine (30%) 20.0
TEA-Cocoyl Glutamate (30%) 5.0
Cocamide DEA 1.0
1,2-Pentanediol 3.0
Glycerin 1.0
Glyceryl Caprylate 0.4
Glyceryl Undecylenate 0.1
Neosolue-AquaS (Nippon Fine Chemical) 1.0
Sorbitol 1.6
Miconazole nitrate 0.75
Glycol distearate 1.5
Polyquaternium-7 0.3
Part B Sodium benzoate 0.4
Sodium chloride 0.2
Purified water (total: 100) C parts 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.5
Aurovisco CS (Oji Holdings) 25.0
Swertia japonica extract 3.0
Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Polyquaternium-47 0.1
Piroctone Olamine 0.1
Purified water 9.7
----------------------------------------------------------------------------------
(Preparation method)
Part B was heated to about 80°C and dissolved uniformly. Part A was placed in a separate container and heated to dissolve. Part B was gradually added to part A and mixed uniformly, and then part C was added at about 60°C.

Example 41 Shampoo
Component Amount (wt%)
------------------------------------------------------------------
Part A Neosolue-DiSM (Nippon Fine Chemical) 0.3
Sodium Cocoyl Sarcosinate 10.0
Sodium cocoyl glutamate (30%) 10.0
Lauryl Hydroxysultaine (30%) 10.0
Glycol distearate 0.5
Stearoxypropyldimethylamine 0.5
Neosolue-AquaS (Nippon Fine Chemical) 0.5
Isostearic acid 0.3
Glyceryl Undecylenate 0.5
BG 0.1
Cocamidomethyl MEA 3.0
Phenoxyethanol 0.6
Part B Citric acid 0.1
Methylparaben 0.2
EDTA-2Na 0.1
Purified water (total: 100) C parts Polyquaternium-10 0.2
Guar Hydroxypropyltrimonium Chloride 0.1
Tremoist-SL (Nippon Fine Chemical) 3.0
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Aurovisco CS (Oji Holdings) 5.0
Purified water 6.7
------------------------------------------------------------------
(Preparation method)
Part A was mixed uniformly at about 80°C. Part B, which had been set aside, was heated to about 60°C and homogenized. Part B was gradually added to part A while stirring, and after mixing uniformly, the mixture was cooled to about 50°C. Part C was then added and mixed uniformly.

Example 42 Leave-on Hair Treatment
Component Amount (wt%)
------------------------------------------------------------------
Part A Neosolue-Aqulio (Nippon Fine Chemical) 2.0
Cetrimonium chloride (25%) 3.8
Isostearic acid 0.02
Erucalactone DES (Nippon Fine Chemical) 1.0
Caprylyl glucoside (50%) 0.8
Glycerin 4.0
1,2-Hexanediol 2.0
Phenoxyethanol 0.5
Part B Ethanol 10.0
Part C Hydrolyzed Keratin 0.2
Hydrolyzed silk 0.1
Hydrolyzed conchiolin 0.1
Polyquaternium-6 0.6
Polyquaternium-7 0.4
Polyquaternium-39 0.5
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.5
Aurovisco CS (Oji Holdings) 30.0
Purified water Amount that makes a total of 100 ---------------------------------
(Preparation method)
Part C was heated to about 80° C. and dissolved. Next, part A was heated to about 80° C. and dissolved. Part A was added to part C while stirring, and after uniformly mixing, the mixture was cooled to about 40° C. Next, part B was added and mixed uniformly.

Example 43: Water-containing gloss
Component Amount (wt%)
------------------------------------------------------------------
Part A Octyldodecanol 27.0
Ethyl cellulose 2.5
Hydrogenated polyisobutene 10.0
Isopropyl sebacate (Nippon Fine Chemical) 3.0
LUSPLAN PI-DA (Nippon Fine Chemical) 2.0
Plandool-G (Nippon Fine Chemical) 0.1
Plandool-SUN (Nippon Fine Chemical) 0.1
Plandool-ISS (Nippon Fine Chemical) 0.1
Plandoool-LG1 (Nippon Fine Chemical) 0.1
Plandoool-LG2 (Nippon Fine Chemical) 0.1
Plandoor-LG3 (Nippon Fine Chemical) 0.1
Plandoor-LG4 (Nippon Fine Chemical) 0.1
Silica dimethyl silylate 0.5
Dextrin palmitate 0.1
PEG-60 Hydrogenated Castor Oil 1.0
Red No. 202 (as needed) Red No. 218 (as needed) Red No. 223 (as needed) Orange No. 201 (as needed) Sorbitan stearate, coconut sucrose fatty acid mixture (ALACEL 2121, manufactured by Croda Co., Ltd.) 3.0
Part B 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.8
Aurovisco CS (Oji Holdings) 4.0
Glycerin 7.0
Neosolue-AquaS (Nippon Fine Chemical) 0.4
Maltose 2.0
Phenoxyethanol 0.2
Water Amount that adds up to 100 ---------------------------------
(Preparation method)
Part A and Part B were each heated and melted to homogenize, and Part B was mixed with Part A.

Example 44 Liquid Foundation
Component Amount (wt%)
------------------------------------------------------------------
Part A Plandool-G (Nippon Fine Chemical) 5.0
Glyceryl stearate (SE) 1.0
PG Stearate (SE) 1.0
Tocopherol 0.1
Propylparaben 1.0
Part B: Titanium oxide and iron oxide mixture (FDP-W-007, manufactured by Toshiki Pigment Co., Ltd.) 18.0
Mica 7.0
BG 5.0
Methylparaben 0.2
Purified water (amount C) totaling 100 parts Cellulose gum (2% aqueous dispersion) 5.0
Xanthan gum (2% aqueous dispersion) 5.0
Aurovisco CS (Oji Holdings) 4.0
Part D 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.8
Purified water 5.0
------------------------------------------------------------------
(Preparation method)
Parts A, B, and C were mixed under heating. Part B was added to part A and emulsified, then cooled to about 50°C, and parts C and D were added and stirred until homogenous.

Example 45 Liquid Foundation
Component Amount (wt%)
------------------------------------------------------------------
Part A Purified water Amount to make a total of 100 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Aurovisco CS (Oji Holdings) 10.0
Carboxyvinyl polymer 0.1
Potassium hydroxide (appropriate amount) DPG 5.0
Preservatives: Appropriate amount Part B: Polyoxyethylene-modified dimethylpolysiloxane 1.0
Trimethylsiloxysilicate 3.0
Phenymethicone 1.0
Cyclomethicone 9.0
Part C: Zinc oxide 10.0
Sericite 0.36
Titanium dioxide 8.32
Iron oxide yellow 0.8
Iron oxide red 0.36
Iron oxide black 0.16
----------------------------------------------------------------------------------
(Preparation method)
After heating and stirring Part A to 70°C, Part C was added and dispersed. This was preheated to 70°C and added to Part B, which was emulsified and dispersed. The mixture was cooled to about 40°C and mixed uniformly.

Example 46 Foundation
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Hydrogenated polyisobutene 5.0
Cyclopentasiloxane 4.0
Mineral oil 4.0
Ethylhexyl methoxycinnamate 3.0
Plandool-H (Nippon Fine Chemical) 1.0
Plandool-G (Nippon Fine Chemical) 1.0
Plandooll-MAS (Nippon Fine Chemical) 1.0
Vaseline 1.0
Phenyl Trimethicone 2.0
Sorbitan Isostearate 1.5
Tribehenin 0.5
(butyl acrylate/glycol dimethacrylate) crosspolymer,
Silica, (methyl methacrylate/glycol dimethacrylate)
Crosspolymer Blend 2.0
Boron nitride 1.0
PEG/PPG-19/19 Dimethicone,
Cyclopentasiloxane Mixture 4.0
Disteardimonium Hectorite (20%) 2.5
Polypropylsilsesquioxane, cyclopentasiloxane mixture
1.0
Mica 15.0
Talc 4.0
Zinc oxide 5.0
Titanium dioxide 10.0
Iron oxide 1.5
Part B Water Amount to make a total of 100 DPG 4.0
Maltitol (75% liquid) 1.0
Neosolue-AquaS (Nippon Fine Chemical) 0.4
Sodium chloride 1.0
BG 1.0
Hyaluronic acid (1% solution) 0.1
Phenoxyethanol 0.3
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.6
Aurovisco CS (Oji Holdings) 4.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was heated to about 70°C and thoroughly stirred to disperse uniformly. Part B was heated to about 70°C and homogenized, after which part B was added to part A, emulsified by stirring at about 70°C, and cooled to about 40°C.

Example 47 Foundation Cream
Component Amount (wt%)
------------------------------------------------------------------
Part A LUSPLAN DD-DA7 (Nippon Fine Chemical) 5.0
Cyclomethicone 14.0
Trimethylsiloxysilicate 3.0
Glyceryl stearate (SE) 2.0
Stearic acid PG (SE) 2.0
Plandooll-MAS (Nippon Fine Chemical) 0.5
Stearic acid 0.5
Palmitic acid 0.5
Ethylhexyl methoxycinnamate 0.5
Tocopherol 0.2
Part B BG 10.0
Ethanol 1.0
Mica 8.0
Talc 7.0
Phenoxyethanol 0.8
Titanate (Li/Cobalt) 0.2
Purified water (total: 100) Part C Dextrin (1%) 1.0
Xanthan gum (10%) 1.0
Cellulose Gum (10%) 1.0
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Aurovisco CS (Oji Holdings) 10.0
Purified water 15.0
------------------------------------------------------------------
(Preparation method)
Part A and Part B were dissolved in separate containers by heating. Part B was added to Part A and emulsified, after which Part C was added and mixed uniformly. After stirring, the mixture was cooled to 40°C.

Example 48 Sunscreen cosmetic
Component Amount (wt%)
------------------------------------------------------------------
Part A Quaternium-18 Hectorite 1.0
Part B Cyclomethicone 13.7
Diphenyl Dimethicone 2.0
Cyclopentasiloxane 10.0
Plandool-H (Nippon Fine Chemical) 1.0
Plandool-G (Nippon Fine Chemical) 0.5
Plandoor-MAS (Nippon Fine Chemical) 2.0
Dicaprylyl Carbonate 1.0
Dimethicone Copolyol 5.5
Part C: Silicone-treated titanium dioxide particles 3.9
Silicone-treated zinc oxide 2.1
Part D: Aluminum stearate 0.7
Al hydroxide 0.5
Isononyl isononanoate 2.5
Neosolue-MP (Nippon Fine Chemical) 1.0
Neosolue-DE (Nippon Fine Chemical) 1.0
Part E Trimethylsiloxysilicate 1.2
Stearyl glycyrrhetinate 0.02
Sorbitan Sesquioleate 2.0
Tocopherol 0.02
Part F: Sodium chloride 1.0
Methylparaben 0.15
Purified water (total: 100) 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Aurovisco CS (Oji Holdings) 10.0
Purified water 10.0
------------------------------------------------------------------
(Preparation method)
Part A was added to part B and stirred. C was then added and dispersed using a roller mill. Part D was heated and melted and added to the mixture of parts A, B, and C, and then part E was added and the temperature was raised to about 70°C. Part F was heated and gradually emulsified into the mixture of parts A to E while stirring. The mixture was cooled with stirring, and part G was added at 40-35°C and mixed uniformly.

Example 49 Sunscreen cosmetic
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Phytocompo-PP (Nippon Fine Chemical) 1.0
BG 10.0
Glycerin 9.0
Part B Octocrylene 4.0
Octyl Salicylate 4.0
Diethylaminohydroxybenzoylhexyl benzoate 2.25
t-Butyl methoxydibenzoylmethane 1.0
Diethylhexyl sebacate (Nippon Fine Chemical) 3.0
Pentaerythrityl tetraethylhexanoate (Nippon Fine Chemical) 2.0
Isopropyl sebacate (Nippon Fine Chemical) 1.0
Behenyl Alcohol 2.0
Cetearyl Alcohol 2.0
Plandooll-MAS (Nippon Fine Chemical) 1.0
Tocopherol 0.05
C part Neosolue-AquaS (Nippon Fine Chemical) 1.0
Methylparaben (as needed) Water (total: 100) Part D Carbomer (2%) 5.0
Water-dispersible titanium dioxide 5.0
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.5
Aurovisco CS (Oji Holdings) 24.0
Tremoist-TP (Nippon Fine Chemical) 0.1
Purified water 10.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was dispersed uniformly. Parts B and C were each heated to about 70°C and dissolved. Part B was gradually added to Part A, and then Part C was gradually added to emulsify. The mixture was cooled with stirring, and Part D was added at 45°C and stirred.

Example 50 Sunscreen cosmetic
Component Amount (wt%)
------------------------------------------------------------------
Part A Phytocompo-PP (Nippon Fine Chemical) 1.0
BG 10.0
Glycerin 9.0
Part B Ethylhexyl methoxycinnamate 7.0
Diethylaminohydroxybenzoylhexyl benzoate 7.0
Behenyl Alcohol 4.0
Plandoool-LG1 (Nippon Fine Chemical) 0.5
Plandooll-MAS (Nippon Fine Chemical) 1.0
Part C Methylparaben 0.15
Purified water (total: 100) D parts Xanthan gum 0.2
Sodium Hyaluronate 0.01
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.7
Aurovisco CS (Oji Holdings) 4.0
Carboxylated cellulose nanofiber (2% aqueous solution) 2.0
Purified water 10.0
------------------------------------------------------------------
(Preparation method)
Part A was dispersed uniformly. Parts B and C were each heated to about 70°C and dissolved. Part B was gradually added to Part A, and then Part C was gradually added to emulsify. The mixture was cooled with stirring, and Parts D and E were added at 45°C and mixed uniformly.

Example 51 Sunscreen cosmetic
Component Amount (wt%)
------------------------------------------------------------------
Part A Phytocompo-PP (Nippon Fine Chemical) 1.0
BG 10.0
Glycerin 9.0
Part B Ethylhexyl methoxycinnamate 7.0
Diethylaminohydroxybenzoylhexyl benzoate 7.0
Behenyl Alcohol 4.0
Plandooll-LG2 (Nippon Fine Chemical) 0.5
Plandooll-MAS (Nippon Fine Chemical) 1.0
Part C Methylparaben 0.15
Purified water (total: 100) D parts Xanthan gum 0.2
Sodium Hyaluronate 0.01
3-O-Ethyl ascorbic acid (Nippon Fine Chemical) 0.7
Carboxylated cellulose nanofiber (2% aqueous solution) 10.0
Purified water 10.0
------------------------------------------------------------------
(Preparation method)
Part A was dispersed uniformly. Parts B and C were each heated to about 70°C and dissolved. Part B was gradually added to Part A, and then Part C was gradually added to emulsify. The mixture was cooled with stirring, and Parts D and E were added at 45°C and mixed uniformly.

Example 52 Skin Care Oil
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Olive oil 24.0
Squalane 24.0
Caprylic/capric triglyceride (Nippon Fine Chemical) 10.0
Plandool-SUN (Nippon Fine Chemical) 2.0
Tocopherol 0.1
Part B 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.3
Aurovisco CS (Oji Holdings) 5.0
Neosolue-AquaS (Nippon Fine Chemical) 0.5
NaCl 0.1
Methylparaben 0.1
Phenoxyethanol 0.4
Water Amount that adds up to 100 -------------------------------------------------
(Preparation method)
Part A was heated to 50° C., dissolved uniformly, and cooled to room temperature. Part B was heated to 80° C., dissolved uniformly, and cooled to about 40° C. Part A and Part B were mixed.

Example 53 Cream
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Glycerin 9.0
DPG 5.0
Phytocompo-PP (Nippon Fine Chemical) 1.0
Part B Mineral oil 8.0
Vaseline 10.0
Pentaerythrityl tetraisostearate 5.0
Astaxanthin 0.01
Cetyl PG Hydroxyethyl Palmitamide 0.05
Sodium cyclic lysophosphatidic acid 0.01
Dipentaerythrityl hexahydroxystearate 1.0
Part C 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Xanthan gum 0.1
Purified water 10.0
Part D Phenoxyethanol 0.4
Ethylhexylglycerin 0.2
Methylparaben 0.05
Purified water E parts totaling 100 Carboxylated cellulose nanofiber (2% aqueous solution) 30.0
----------------------------------------------------------------------------------
(Preparation method)
Parts A, B, and D were mixed and heated to about 70°C to dissolve and disperse uniformly. Part C was mixed and stirred to form a viscous liquid. Part B was added to Part A while stirring with a homodisper, and then Part D was added to emulsify. The mixture was cooled, and at about 50°C, parts C and E were added, and the mixture was stirred and cooled to about 40°C.

Example 54 Lotion
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Phytopresome (Nippon Fine Chemical) 0.2
BG 10.0
Part B Purified water 20.0
Part C 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 0.8
Neosolue-Aquilio (Nippon Fine Chemical) 1.0
Succinic acid 0.1
Sodium succinate (appropriate amount) Phenoxyethanol 0.2
Methylparaben 0.15
Purified water (amount D) totaling 100 Carboxylated cellulose nanofiber (2% aqueous solution) 10.0
----------------------------------------------------------------------------------
(Preparation method)
Part A was mixed and slowly added to part B while stirring. Parts C and D, which had been mixed in advance, were then added to make a homogeneous solution.

Example 55 Sunscreen
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Ethylhexyl methoxycinnamate 10.0
Dimethicone 25.0
Trimethylsiloxysilicate, Polypropylsilsesquioxane 4.0
PEG-10 Dimethicone 4.0
Isododecane, Disteardimonium Hectorite, Propylene Carbonate 4.0
Part B: Titanium dioxide, hydrated silica, hydrodimethicone 5.0
Part C Water Amount that makes a total of 100 Auro Visco CS (Oji Holdings) 1.0
Ethanol 3.0
BG 6.0
Phenoxyethanol 0.4
Part D 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
water 5.0
----------------------------------------------------------------------------------
(Preparation method)
Parts A and C were each heated to about 80° C. to dissolve them. Part B was added to Part A, and then Part C was gradually added and emulsified. The mixture was cooled with stirring, and Part D was added at 45° C. and stirred.

Example 56 Foundation
Component Amount (wt%)
----------------------------------------------------------------------------------
Part A Ethylhexyl methoxycinnamate 6.0
Titanium oxide, aluminum hydroxide, dimethicone 12.0
Iron Oxide, Dimethicone 1.4
Part B Dimethicone 23.0
Trimethylsiloxysilicate, Polypropylsilsesquioxane 3.0
PEG-10 Dimethicone 4.0
Part C: Synthetic Fluorphlogopite (synthetic gold mica), Hydrogen Dimethicone 3.0
Silica dimethyl silylate 1.5
Isododecane, Disteardimonium Hectorite, Propylene Carbonate 3.0
Part D Purified water Amount that makes a total of 100 Aurovisco CS (Oji Holdings) 1.0
Ethanol 3.0
BG 6.0
Phenoxyethanol 0.4
Part E 3-O-ethyl ascorbic acid (Nippon Fine Chemical) 1.0
Purified water 5.0
----------------------------------------------------------------------------------
(Preparation method)
After kneading part A, part B is added and heated to 80° C. After mixing part C, part D, which has been heated and dissolved to about 80° C., is added and emulsified. The mixture is cooled with stirring, and part E is added at 45° C. and stirred.

In the above prescription, details of the ingredients listed by product name are as follows:

LUSPLAN PI-DA: Dimer dilinoleate di(isostearyl/phytosteryl)
○ LUSPLAN DD-IS: Dimer dilinoleyl diisostearate ○ LUSPLAN DD-DA7: Dimer dilinoleyl dimer dilinoleate ○ LUSPLAN SR-DM4: Dimer dilinoleyl dimer dilinoleate, tri(caprylic/capric)glyceryl ○ Inulin-SC: Inulin ○ Neosolue-Aquilio: Bisethoxydiglycol cyclohexanedicarboxylate ○ Neosolue-Aqua: Polyglyceryl-10 (eicosanedioate/tetradecanedioate)
Neosolue-AquaS: Polyglyceryl-10 (eicosanedioate/tetradecanedioate)
Neosolue-DiSM: Diisostearyl malate Neosolue-DE: Diethylpentanediol dineopentanoate Neosolue-MP: Methylpentanediol dineopentanoate Plandoor-DP: Bisdiglyceryl polyacyladipate-2
Plandool-ISS: Phytosteryl Isostearate Plandool-SUN: Phytosteryl Sunflower Seed Oil Fatty Acid Plandool-MAS: Phytosteryl Macadamia Nut Oil Fatty Acid Plandool-LG1: Phytosteryl/Octyldodecyl/Behenyl Lauroyl Glutamate
Plandoor-LG2: Phytosteryl/Octyldodecyl Lauroyl Glutamate
Plandoor-LG3: Phytosteryl/Octyldodecyl/Behenyl Lauroyl Glutamate
Plandoor-LG4: Phytosteryl/Octyldodecyl/Behenyl Lauroyl Glutamate
Plandoor-G: Dimer dilinoleyl bis(behenyl/isostearyl/phytosteryl) dimer dilinoleate
Plandoor-H: Dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl)
Plandoor-S: Dimer dilinoleic acid (phytosteryl/isostearyl/cetyl/stearyl/behenyl)
Phytopresome: Hydrogenated lecithin, phytosterols Phytopresome MEL: Glycolipids, hydrogenated lecithin, BG, purified water Phytocompo-PP: Hydrogenated lecithin, phytosterols Phytocompo-C: Hydrogenated lecithin, phytosterols, ceramide 2, ceramide 3, ceramide 6II
PrimeLipid PI: hydrogenated lecithin, lecithin, phytosterol, tocopherol Tremoist-SL: Tremella fuciformis polysaccharide aqueous solution (1%)
Tremoist-TP: Tremella fuciformis polysaccharide Erucalactone DES: γ-docosalactone, diethyl sebacate Erucalactone MCT: γ-docosalactone, caprylic/capric triglyceride

Claims (1)

A cosmetic or topical skin preparation containing the following components (A) to (D) and having a pH of 3.5 to 5.5 :
(A) 0.01 to 5% by mass of cellulose nanofibers having phosphate groups
(B) 0.01 to 2% by mass of 3-O-ethyl ascorbic acid
(C) 1 to 50% by mass of one or more selected from monohydric alcohols and polyhydric alcohols having 1 to 3 carbon atoms
(D) chelating agent : 0.01 to 5% by mass