JP7780474B2 - Oral appliance cleaner - Google Patents

Description

This disclosure relates to an oral appliance cleanser that has excellent deodorizing properties and, despite containing an oxygen bleach and a fragrance, can impart a sufficient fragrance to oral appliances after cleaning.

Dentures and other oral appliances are prone to accumulating bacteria, biofilms, and other deposits. If left uncleaned, this can not only cause bad breath, but can also contribute to oral diseases such as periodontal disease. Therefore, as part of oral care, it is essential to clean and keep oral appliances clean. Bacteria and dirt adhering to oral appliances cannot be sufficiently removed by brushing, so cleaning with a detergent is important.

Cleaning of intraoral appliances with a detergent is generally performed by adding the detergent to water to prepare cleaning water, and then immersing the intraoral appliances in the water. Traditionally, intraoral appliance cleaners have been formulated with surfactants and foaming agents (carbonates and acids), and are designed to enhance cleaning effectiveness by exerting chemical cleaning power through surface activation and physical cleaning power through foaming when added to water.

In addition, oral appliance cleaners generally contain bleaching agents to impart a bleaching effect and improve cleaning and deodorizing power. For example, Patent Document 1 proposes a denture cleaner containing an oxygen-based bleaching agent. By incorporating an oxygen-based bleaching agent into a denture cleaner, it is possible to impart excellent deodorizing power to the denture cleaner.

Flavors such as mint oil and l-menthol may also be added to intraoral appliance cleansers to reduce the odor of the intraoral appliance and to provide a refreshing feeling to the wearer when reinserting the appliance after cleaning.

Japanese Patent Application Laid-Open No. 2005-272365

However, when an oxygen bleach and fragrance are blended into an intraoral instrument cleanser, the fragrance is altered by the oxygen bleach in the intraoral instrument cleanser, resulting in a loss of fragrance in the intraoral instrument cleansing water prepared by adding the intraoral instrument cleanser to water, creating the problem of not being able to impart a sufficient fragrance to the intraoral instruments after cleaning.

The objective of this disclosure is to provide an oral appliance cleanser that has excellent deodorizing properties and, despite containing oxygen bleach and fragrance, can impart a sufficient fragrance to oral appliances after cleaning.

The inventors conducted extensive research to solve the above-mentioned problems and discovered that by incorporating cyclodextrin into an intraoral instrument cleanser along with an oxygen bleach and fragrance, not only is deodorizing power improved, but also, in intraoral instrument cleaning water prepared by adding the intraoral instrument cleanser to water, the loss of fragrance caused by the oxygen bleach is suppressed, allowing intraoral instruments to retain a sufficient fragrance after cleaning. The present disclosure was completed based on this finding and through further research.

That is, the present disclosure provides the inventions of the following aspects.
Item 1. An oral instrument cleanser comprising: (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates; (B) an acid; (C) an oxygen bleaching agent; (D) a flavoring; and (E) a cyclodextrin.
Item 2. The cleanser for oral instruments according to Item 1, wherein the oxygen bleaching agent is monopersulfate.
Item 3. The cleanser for oral instruments according to Item 1 or 2, further comprising (F) a bleaching activator.
Item 4. The cleanser for intraoral instruments according to Item 3, wherein the bleaching activator is tetraacetylethylenediamine.
Item 5. The intraoral instrument cleanser according to any one of Items 1 to 4, which is a denture cleanser.
Item 6. Use of a composition comprising (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates, (B) an acid, (C) an oxygen bleaching agent, (D) a flavoring, and (E) a cyclodextrin, for cleaning an intraoral appliance.
Item 7. Use of a composition comprising (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates, (B) an acid, (C) an oxygen bleaching agent, (D) a flavoring, and (E) a cyclodextrin, as an intraoral instrument cleanser.
Item 8. A method for cleaning an intraoral instrument, comprising immersing an intraoral instrument in water containing an intraoral instrument cleaner containing: (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates; (B) an acid; (C) an oxygen bleaching agent; (D) a fragrance; and (E) cyclodextrin.

The intraoral appliance cleaner of the present disclosure has excellent deodorizing properties due to the oxygen bleach and cyclodextrin, and while it contains an oxygen bleach and a fragrance, it can inhibit the loss of fragrance caused by the oxygen bleach in the intraoral appliance cleaning water prepared by adding the intraoral appliance cleaner to water, thereby imparting a sufficient fragrance to the intraoral appliance after cleaning. This reduces the odor of the intraoral appliance after cleaning, allowing the wearer to feel sufficiently refreshed when re-wearing the intraoral appliance after cleaning.

In this specification, the notation X to Y regarding a numerical range means that the range is from X to Y.

In this specification, "intraoral appliances" refers to dental appliances that must be worn and removed in the oral cavity, such as complete dentures, partial dentures, orthodontic appliances, retainers, and mouthpieces.

1. Intraoral Instrument Cleanser The intraoral instrument cleanser of the present disclosure is characterized by comprising (A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates (hereinafter sometimes referred to as component (A)), (B) an acid (hereinafter sometimes referred to as component (B)), (C) an oxygen-based bleaching agent (hereinafter sometimes referred to as component (C)), (D) a fragrance (hereinafter sometimes referred to as component (D)), and (E) a cyclodextrin (hereinafter sometimes referred to as component (E)). The intraoral instrument cleanser of the present disclosure is described in detail below.

[Carbonate compounds]
The intraoral instrument cleanser of the present disclosure contains, as component (A), at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates. Carbonate compounds are known components that constitute foaming agents for intraoral instrument cleansers.

The carbonate salts are not particularly limited, but examples include alkali metal salts of carbonate such as sodium carbonate and potassium carbonate, with sodium carbonate being preferred. The bicarbonate salts are not particularly limited, but examples include alkali metal salts of bicarbonate such as sodium bicarbonate and potassium bicarbonate, with sodium bicarbonate being preferred. The double salts of carbonate and bicarbonate are not particularly limited, but examples include sodium sesquicarbonate. The above-exemplified carbonate compounds may be used alone or in combination of two or more.

In the intraoral instrument cleanser of the present disclosure, the content of component (A) is not particularly limited as long as sufficient carbon dioxide bubbles can be generated when cleaning intraoral instruments, but examples include 1 to 40% by weight, preferably 3 to 30% by weight, and more preferably 5 to 25% by weight.

[acid]
The intraoral instrument cleanser of the present disclosure contains an acid as component (B). Acids are known components that constitute foaming agents for intraoral instrument cleansers.

Acids include organic acids and inorganic acids, with organic acids being preferred. Organic acids are not particularly limited, but examples include citric acid, tartaric acid, fumaric acid, malic acid, maleic acid, gluconic acid, succinic acid, and salicylic acid. Inorganic acids are not particularly limited, but examples include phosphoric acid and sulfamic acid. The above-listed acids may be used alone or in combination of two or more.

In the intraoral instrument cleanser of the present disclosure, the content of component (B) is not particularly limited as long as sufficient carbon dioxide bubbles can be generated when cleaning intraoral instruments, but examples include 1 to 60% by weight, preferably 3 to 40% by weight, and more preferably 5 to 20% by weight.

In the intraoral instrument cleanser of the present disclosure, the content of component (B) is not particularly limited, as long as it can react with component (A) in water to generate carbon dioxide. However, the content of component (B) per 100 parts by weight of component (A) is, for example, 50 to 500 parts by weight, preferably 75 to 420 parts by weight, and more preferably 80 to 320 parts by weight.

[Oxygen bleach]
The intraoral instrument cleanser of the present disclosure contains an oxygen bleaching agent as component (C). The oxygen bleaching agent is a component that generates HO ₂ ⁻ in water. By including an oxygen bleaching agent in the intraoral instrument cleanser, it is possible to impart excellent deodorizing power to the intraoral instrument cleanser.

There are no particular limitations on the oxygen bleaching agent, so long as it is non-toxic and physiologically acceptable, and a wide range of agents commonly used in intraoral instrument cleansers can be used. Examples of oxygen bleaching agents include percarbonates, perborates, persulfates, and monopersulfates. The oxygen bleaching agents exemplified above may be used alone or in combination of two or more.

Specific examples of percarbonates include alkali metal salts of percarbonate such as sodium percarbonate and potassium percarbonate, ammonium percarbonate, and hydrates thereof. Specific examples of perborates include alkali metal salts of perboric acid such as sodium perborate and potassium perborate, ammonium perborate, and hydrates thereof. Specific examples of persulfates include alkali metal salts of persulfate such as sodium persulfate and potassium persulfate, ammonium persulfate, and hydrates thereof. Specific examples of monopersulfates include alkali metal salts of monopersulfate such as sodium monopersulfate and potassium monopersulfate, ammonium monopersulfate, and hydrates thereof. The above-exemplified oxygen bleaches may be used alone or in combination of two or more. Of the above-exemplified oxygen bleaches, monopersulfates are preferred, and potassium monopersulfate is more preferred, from the viewpoint of further suppressing the loss of fragrance in the rinse water for intraoral appliances.

In the intraoral instrument cleanser of the present disclosure, the content of component (C) may be appropriately set within a range that achieves the desired deodorizing effect, for example, 1 to 40% by weight. From the perspective of enhancing deodorizing effect and further suppressing the fading of the fragrance of the fragrance in the intraoral instrument cleanser, the content is preferably 2 to 30% by weight, and more preferably 3 to 20% by weight.

[Fragrance]
The intraoral instrument cleanser of the present disclosure contains a flavor as component (D). The flavor is a component for imparting a fragrance to the intraoral instrument after cleaning.

The flavoring agent is not particularly limited, and a wide variety of oil-based flavoring agents commonly used in oral instrument cleansers can be used. Examples of flavoring agents include l-menthol, l-carvone, cinnamic aldehyde, orange oil, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spilanthol, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenylglycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, maltol, ethyl maltol, and gamma/delta decalactone. , gamma/deltaundecalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-1-menthyl carbonate, and other fragrance ingredients; natural essential oils such as peppermint oil, spearmint oil, eucalyptus oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, and paracles oil; and blended flavors such as orange, apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, and yogurt. The above-exemplified fragrances may be used alone or in combination of two or more. Of the above-exemplified fragrances, natural essential oils are preferred, and mint oil is more preferred.

In the intraoral instrument cleanser of the present disclosure, the content of component (D) may be set appropriately within a range that imparts the desired fragrance to the intraoral instrument after cleaning, and is, for example, 0.1 to 5% by weight. From the viewpoint of imparting an appropriate fragrance to the intraoral instrument after cleaning, the content is preferably 0.2 to 3% by weight, and more preferably 0.3 to 2% by weight.

In the intraoral instrument cleanser of the present disclosure, the content ratio of component (D) to component (C) is not particularly limited. For example, the content of component (D) is 0.5 to 25 parts by weight per 100 parts by weight of component (C). From the viewpoint of further suppressing the decline in the fragrance of the flavoring in the intraoral instrument cleansing water and from the viewpoint of imparting a sufficient fragrance to the intraoral instrument after cleaning, the content is preferably 1 to 20 parts by weight, and more preferably 1.5 to 15 parts by weight.

[Cyclodextrin]
The intraoral instrument cleanser of the present disclosure contains cyclodextrin as component (E). In the intraoral instrument cleanser of the present disclosure, cyclodextrin is a component that imparts excellent deodorizing power and also suppresses the deterioration of the fragrance of the fragrance caused by oxygen bleach in an intraoral instrument cleansing water prepared by adding the intraoral instrument cleansing agent to water. Because cyclodextrin has an inclusion function, it is thought that in an intraoral instrument cleansing water prepared by adding the intraoral instrument cleansing agent to water, the cyclodextrin improves the deodorizing power by encapsulating malodorous components, and that the cyclodextrin encapsulates the fragrance, thereby suppressing the deterioration of the fragrance caused by oxygen bleach.

Cyclodextrins are not particularly limited, and examples include those with five or more glucose atoms bonded together. Specific examples include α-cyclodextrin with six glucose atoms bonded together, β-cyclodextrin with seven glucose atoms bonded together, γ-cyclodextrin with eight glucose atoms bonded together, and Cluster Dextrin (registered trademark), a highly branched cyclic dextrin. Cluster dextrin is commercially available from Nihon Shokuhin Kako Co., Ltd., Ezaki Glico Co., Ltd., and other companies. The above-listed cyclodextrins may be used alone or in combination of two or more.

From the perspective of further improving deodorizing power and effectively suppressing the fading of fragrance in the rinse water for intraoral appliances, it is preferable to use at least one type of cyclodextrin selected from the group consisting of α-, β-, and γ-cyclodextrin, more preferably at least two types selected from the group consisting of α-, β-, and γ-cyclodextrin, and even more preferably three types of α-, β-, and γ-cyclodextrin. When α-, β-, and γ-cyclodextrin are used, the weight ratios of α-, β-, and γ-cyclodextrin are not particularly limited, but from the perspective of further improving deodorizing power and more effectively suppressing fading of the fragrance of the fragrance in the rinse water for intraoral appliances, when the total amount of α-, β-, and γ-cyclodextrins is taken as 100 parts by weight, the content of α-cyclodextrin is preferably 20 to 40 parts by weight, more preferably 25 to 35 parts by weight, the content of β-cyclodextrin is preferably 35 to 70 parts by weight, more preferably 45 to 60 parts by weight, and the content of γ-cyclodextrin is preferably 10 to 25 parts by weight, more preferably 15 to 20 parts by weight.

In the intraoral instrument cleanser of the present disclosure, the content of component (E) may be adjusted appropriately depending on the content of the fragrance, and is, for example, 0.01 to 5% by weight. From the viewpoints of further improving deodorizing power, effectively suppressing the fading of the fragrance in the intraoral instrument cleansing water, and imparting an appropriate fragrance to the intraoral instrument after cleaning, the content is preferably 0.05 to 3% by weight, more preferably 0.1 to 2% by weight, even more preferably 0.1 to 1.5% by weight, even more preferably 0.1 to 1% by weight, and particularly preferably 0.2 to 0.7% by weight.

In the intraoral instrument cleanser of the present disclosure, the ratio of component (E) to component (D) is not particularly limited, and the content of component (E) per 1 part by weight of component (D) is, for example, 0.01 to 3 parts by weight. From the viewpoint of effectively suppressing the fading of the fragrance of the flavoring in the intraoral instrument cleansing water and from the viewpoint of imparting an appropriate fragrance to the intraoral instruments after cleaning, the content is preferably 0.05 to 2.5 parts by weight, more preferably 0.1 to 2.3 parts by weight, and even more preferably 0.1 to 2 parts by weight.

[Bleach activator]
The intraoral instrument cleanser of the present disclosure may contain a bleaching activator (F) (hereinafter, sometimes referred to as component (F)). The bleaching activator is a component that reacts with _HO generated from the oxygen ^- based bleach in water to generate an organic peracid that has a stronger bleaching effect.

The bleach activator may be any known bleach activator without particular limitation, and examples thereof include tetraacetylethylenediamine; alkanoyloxybenzenesulfonic acids or salts thereof having an alkanoyl group containing 1 to 18 carbon atoms, preferably 8 to 12 carbon atoms; and alkanoyloxybenzoic acids or salts thereof having an alkanoyl group containing 1 to 18 carbon atoms, preferably 8 to 12 carbon atoms. Examples of the salts include alkali metal salts and ammonium salts. The bleach activators listed above may be used alone or in combination of two or more. Among the bleach activators listed above, tetraacetylethylenediamine is preferred due to its excellent efficiency in generating organic peracids.

In the intraoral instrument cleanser of the present disclosure, the content of component (F) may be adjusted appropriately depending on the content of the oxygen bleach, and is, for example, 0.01 to 5% by weight. From the viewpoint of imparting excellent deodorizing power, it is preferably 0.1 to 3% by weight, and more preferably 0.5 to 2% by weight.

[silica]
The intraoral instrument cleanser of the present disclosure may contain (G) silica (hereinafter, may be referred to as component (G)). In the intraoral instrument cleanser of the present disclosure, silica is a component that is impregnated with a flavor and contributes to improving the storage stability of the flavor. Silica is a general term for silicon dioxide or a substance composed of silicon dioxide.

In the intraoral instrument cleanser of the present disclosure, the content of component (G) may be adjusted appropriately depending on the content of the fragrance, and is, for example, 0.01 to 5% by weight. From the viewpoint of further improving the storage stability of the fragrance, the content is preferably 0.1 to 3% by weight, more preferably 0.5 to 2% by weight, and even more preferably 0.5 to 1% by weight.

[Other ingredients]
In addition to the components described above, the oral instrument cleanser of the present disclosure may contain other components as needed, to the extent that the effects of the present disclosure are not impaired.

Other additives that can be incorporated into the intraoral instrument cleanser of the present disclosure include magnesium oxide, surfactants, binders, deodorizers, rust inhibitors, chelating agents, pH adjusters, enzymes, sweeteners, foam stabilizers, preservatives, antibacterial/bactericidal agents, antiseptics, lubricants, bulking agents, excipients, disintegrants, and fluidizing agents. The other components exemplified above may be incorporated alone or in any combination of two or more.

2. Formulation of the intraoral instrument cleanser The intraoral instrument cleanser of the present disclosure is in a solid form, specifically, molded into a powder, granules, or tablet, preferably molded into a granule or tablet, and most preferably molded into a tablet. When molded into a tablet, the weight per tablet is not particularly limited and may be appropriately set taking into account ease of use, but it is desirable to set the weight per tablet to the amount necessary for one intraoral instrument cleanse.

The tablet-form intraoral instrument cleanser may be manufactured according to known methods. For example, the intraoral instrument cleanser of the present disclosure can be manufactured by subjecting a mixture of the components (A) to (E) and other components, if necessary, to a granulation process or tablet compression process.

3. Uses of the Cleanser for Intraoral Instruments The cleanser for intraoral instruments of the present disclosure is used as a cleaner for various intraoral instruments, but is particularly suitable for use as a denture cleaner.

4. Method of Using the Intraoral Instrument Cleanser The intraoral instrument cleanser of the present disclosure is added to water, heated if necessary, and then the intraoral instrument (preferably a denture) to be cleaned is placed therein. The foaming action caused by the reaction of components (A) and (B) cleans the intraoral instrument. Furthermore, the intraoral instrument cleanser of the present disclosure contains components (C) and (E), thereby exhibiting excellent deodorizing and cleaning power. Furthermore, the intraoral instrument cleanser of the present disclosure, while containing components (C) and (D), also contains component (E), thereby effectively suppressing the loss of fragrance due to oxygen bleach in the intraoral instrument cleaning water, thereby imparting a sufficient fragrance to the intraoral instrument after cleaning. This reduces the odor of the intraoral instrument after cleaning, allowing the wearer to feel sufficiently refreshed when re-wearing the intraoral instrument after cleaning.

The water used when cleaning intraoral instruments using the intraoral instrument cleanser of the present disclosure is not particularly limited, but may include tap water, purified water, distilled water, saline water, etc.

When cleaning intraoral appliances using the intraoral appliance cleanser of the present disclosure, the intraoral appliances may be immersed in water and then the intraoral appliance cleanser of the present disclosure added, or the intraoral appliances may be immersed in water after the intraoral appliance cleanser of the present disclosure has been added.

In addition, when cleaning intraoral instruments, the ratio of the intraoral instrument cleanser of the present disclosure to water is appropriately set depending on the composition of the intraoral instrument cleanser of the present disclosure, the degree of soiling of the intraoral instruments to be cleaned, etc., but for example, the ratio of the intraoral instrument cleanser to 100 parts by weight of water is usually about 1 to 10 parts by weight, preferably about 1 to 5 parts by weight. More specifically, for each cleaning of intraoral instruments, 100 to 200 mL of water is prepared, to which 1 to 20 g, preferably 1 to 10 g, more preferably 1 to 5 g, of the intraoral instrument cleanser of the present disclosure is added.

The temperature during cleaning of intraoral instruments should be approximately room temperature. Furthermore, the time for immersing intraoral instruments in the cleaning solution is typically approximately 5 minutes to 24 hours, preferably approximately 10 minutes to 12 hours, and more preferably approximately 30 minutes to 8 hours.

Furthermore, while cleaning the intraoral appliances, it is not necessary to agitate the water to which the intraoral appliance cleanser has been added, but it may be stirred if necessary, and the intraoral appliances may also be scrubbed with a cleaning tool such as a brush.

The following examples are provided to more specifically explain the invention of this disclosure, but the disclosure is not limited to these examples.

The compositions of the cyclodextrins used in the following test examples and formulation examples are as follows:
Cyclodextrin: a mixture of 13 parts by weight of α-cyclodextrin, 20 parts by weight of β-cyclodextrin, 7 parts by weight of γ-cyclodextrin, and 60 parts by weight of powdered sugar. Mint flavor: a synthetic flavor. A mixture of potassium sulfate, potassium hydrogen sulfate, and potassium monopersulfate (containing approximately 43% by weight of potassium monopersulfate).

Test Example: Tablet-shaped intraoral instrument cleaners were prepared with the compositions shown in Table 1. Specifically, the compositions prepared by mixing the components shown in Table 1 were tableted at 47 MPa using a 25φ diameter mold and a tableting machine (SMP-3012SK, small electric hydraulic pump, manufactured by Riken Kiki Co., Ltd.), to prepare tablets weighing 2.65 g each. In Table 1, the units of values indicating the blending amount of each component are % by weight. Furthermore, in Table 1, the blending amount in the cyclodextrin column indicates the total blending amount of α-, β-, and γ-cyclodextrin.

The prepared oral instrument cleanser was subjected to deodorizing tests and fragrance lingering tests using the following methods.

<Deodorization Test A>
200 μl of a malodorous aqueous solution containing methyl mercaptan (methyl mercaptan concentration: 3000 ppm) was placed in a glass container. Furthermore, one tablet of each of the intraoral instrument cleaners prepared in Examples 1 to 6, Comparative Examples 1 to 6, and Reference Example 1 was placed in 180 ml of water at 25°C to prepare a cleaning solution. Then, 400 μl of each of the prepared cleaning solutions was added to the glass container, and the opening of the glass container was sealed with paraffin film. The glass container was then left to stand at 25°C for 30 minutes. Thereafter, the concentration (ppm) of methyl mercaptan contained in the gas in the glass container was measured using a detector tube gas measuring instrument and a detector tube 71H (manufactured by Gastec Corporation). The results are shown in Table 1.

<Deodorization Test B>
Denture material resin chips (20 mm x 20 mm x 1.5 mm) were immersed in the malodorous aqueous solution used in Deodorization Test A. Cleaning solutions were prepared by placing one tablet of each of the intraoral instrument cleaners prepared in Examples 1 to 6, Comparative Examples 1 to 6, and Reference Example 1 into a glass container containing 180 ml of water at 25°C. Resin chips removed from the malodorous aqueous solution were immersed in each of the prepared cleaning solutions and allowed to stand at 25°C for 3 hours to clean the resin chips. After cleaning, the resin chips were removed and placed in a 10-liter airbag, which was filled with 1.5 liters of odorless air per five resin chips. After standing at 25°C for 10 minutes, the gas in the airbag was subjected to a sensory evaluation of deodorizing properties. The sensory evaluation of deodorizing properties was performed using a 6-level odor intensity method and a 9-level pleasantness/unpleasantness rating system.

[6-level odor intensity method]
The odor intensity of the gas inside the airbag was scored using a six-point odor intensity method (0: no odor, 1: barely detectable odor, 2: weak odor that is identifiable, 3: easily detectable odor, 4: strong odor, 5: intense odor). The odor intensity was scored by eight trained sensory evaluation monitors who had passed an olfactory blindness test, and the average score of the six monitors was used, excluding one monitor who scored the highest and one monitor who scored the lowest. The results are shown in Table 1.

[9-point comfort/discomfort scale]
The comfort and discomfort of the gas inside the airbag was scored using a 9-point comfort and discomfort scale (-4 points: extremely uncomfortable, -3 points: very uncomfortable, -2 points: uncomfortable, -1 point: slightly uncomfortable, 0 point: neither comfortable nor uncomfortable, 1 point: slightly comfortable, 2 points: comfortable, 3 points: very comfortable, 4 points: extremely comfortable). The comfort and discomfort scores were scored by the eight sensory evaluation monitors, and the average score of the six monitors was used, excluding one monitor who scored the highest and one monitor who scored the lowest. The results are shown in Table 1.

<Fragrance scent lingering test>
The fragrance lingering test was performed by a three-point comparison method. Two cleaning solutions (reference solutions) were prepared by adding one tablet of the intraoral instrument cleanser prepared in Reference Example 1 to 180 ml of water at 25°C, and one cleaning solution (evaluation solution) was prepared by adding one tablet of each of the intraoral instrument cleansers prepared in Examples 1 to 6 and Comparative Examples 1 to 6 to 180 ml of water at 25°C. Three hours after the preparation of the cleaning solutions, the eight sensory evaluation monitors compared the lingering fragrance of the fragrance using the two reference solutions and the one evaluation solution.
If five or more people out of eight judged that the evaluation liquid had a "decreased fragrance lingering" compared with the reference liquid, the two were judged to be distinguishable (they were able to recognize the decrease in fragrance lingering), and if four or fewer people out of eight judged that they were indistinguishable (they were unable to recognize the decrease in fragrance lingering). Evaluation liquids judged to be indistinguishable were rated "A" for fragrance lingering. Furthermore, those who judged that they were able to distinguish between the two (they were able to recognize the decrease in fragrance lingering) were asked to answer the question "Is the difference in fragrance lingering a problem in terms of product performance?" on a two-point scale (problem, no problem), and the fragrance lingering was evaluated according to the following criteria. The results are shown in Table 1.
B: The total number of people who answered "no problem" is 60% or more. C: The total number of people who answered "no problem" is less than 60%.

The results in Table 1 show that the intraoral instrument cleansers of Examples 1 to 6, which contain cyclodextrin, have superior deodorizing effects compared to the intraoral instrument cleansers of Comparative Examples 1 to 6, which do not contain cyclodextrin, and are also able to effectively prevent the fading of fragrance.

Formulation Examples Tablet-shaped intraoral instrument cleansers were prepared having the compositions shown in Tables 2 and 3. In Tables 2 and 3, the units of values indicating the blending amount of each component are % by weight. In Tables 2 and 3, the blending amount in the cyclodextrin column indicates the total blending amount of α-, β-, and γ-cyclodextrin. All of the intraoral instrument cleansers had excellent deodorizing power and were able to impart a sufficient fragrance to the intraoral instruments after cleaning.

Claims (5)

(A) at least one carbonate compound selected from the group consisting of carbonates, bicarbonates, and double salts of bicarbonates and carbonates; (B) an acid; (C) an oxygen bleach; (D) a fragrance; and (E) a cyclodextrin;
An oral instrument cleanser (excluding those containing catechins) in which the content of (E) cyclodextrin is 0.1 to 2 parts by weight per 1 part by weight of (D) flavoring . The oral instrument cleanser according to claim 1, wherein the oxygen bleaching agent is monopersulfate. The oral instrument cleanser according to claim 1, further comprising (F) a bleaching activator. The oral instrument cleanser according to claim 3, wherein the bleaching activator is tetraacetylethylenediamine. The intraoral instrument cleanser according to any one of claims 1 to 4, which is a denture cleanser.