JP7787844B2 - Adjuvant-containing composition - Google Patents

Description

The present invention relates to a composition containing an adjuvant.

In the livestock farming sector, improving the environment in which livestock livestock grow is an important issue from the perspective of profitability. Microbial contamination of livestock animals also affects profitability. Therefore, environmental improvement materials are used to improve the growing environment, and disinfectants and insecticides for disease prevention are used to treat or prevent microbial infections or disorders related to microbial infections in animals.

Patent Document 1 describes an environmental improvement material made by mixing pulverized coal combustion ash, a water-soluble polymer, finely powdered blast furnace slag, and gypsum and granulating it into circular shapes with a cross section of 5 to 20 mm and a length of 10 to 50 mm. It describes that this material can be used for a wide range of purposes, including as an adsorbent for moisture and oil, as bedding to deodorize animal feces and urine in livestock barns and zoos, as a fermentation promoter for compost production, as a soil pH adjuster, as fertilizer, and as an adsorbent for internal organs, blood, filth, etc. in slaughterhouses.

Patent Document 2 discloses that a composition containing formic acid or a pharmaceutically acceptable salt thereof, glycerol, one or more butyric acid glycerides, and optionally butyric acid in a specific ratio is effective for the prevention and treatment of infectious diseases in livestock animals.
These environment-improving materials and compositions are used by scattering them in required locations in livestock sheds and the like.

Japanese Patent Application Laid-Open No. 2007-007610 Special Publication No. 2021-528078

However, for various reasons, the active ingredients and other components of the environmental improvement materials and compositions described in Patent Documents 1 and 2 are unable to remain at the application site and are washed away. As a result, the components contained in the environmental improvement materials and compositions may flow into the surrounding area of livestock barns or into sewers, potentially polluting the environment. Furthermore, because the environmental improvement materials and compositions are washed away, the effects of the environmental improvement materials, etc., are not sustained and the full effects of the environmental improvement materials, etc. cannot be obtained.

The present invention therefore aims to provide an adjuvant-containing composition that, when used in combination with known environmental improvement materials and known disease prevention pesticides, etc., used in the livestock farming field, can further enhance the effects of the environmental improvement materials and active ingredients, and also reduce the amount of known environmental improvement materials and known disease prevention pesticides, etc., used.

As a result of extensive research into achieving the above-mentioned objectives, the inventors discovered that the above-mentioned problems can be solved by using a dispersion containing water and fine fibers made up of microfibers and nanofibers with specific fiber widths and lengths in combination with known environmental improvement materials or existing disease prevention pesticides, etc., so that the active ingredients of the environmental improvement materials or disease prevention pesticides are adsorbed onto the fine fibers, and the fine fibers are then attached to the areas in the livestock barns where they are to be sprayed.

The present invention provides an adjuvant and an adjuvant-containing composition that can further enhance the effectiveness of environmental improvement materials and chemicals when used in combination with known environmental improvement materials and known disease prevention insecticides used in the livestock farming field. It also provides an adjuvant and an adjuvant-containing composition that can reduce the amount of environmental improvement materials and chemicals used.

FIG. 1 shows the state of the adjuvant-containing composition according to the present invention after drying at room temperature. FIG. 2 shows the state in which the active ingredient is fixed in the form of fine fibers when the adjuvant-containing composition according to the present invention is dried at room temperature.

The adjuvant and the adjuvant-containing composition according to the present invention will be described in detail below. However, the following embodiments are intended to aid in understanding the invention and are not intended to limit the invention.
In the drawings used to explain the following embodiments, the same reference symbols represent the same or corresponding parts. In this specification, an expression in the form of "A to B" means the upper and lower limits of a range (i.e., A or more and B or less), and when no unit is specified for A and a unit is specified only for B, the unit of A and the unit of B are the same.

(Definition of terms)
The term "adjuvant" as used herein refers to a dispersion containing fine fibers that is used in combination with known environmental improvement materials and the like.
The term "adjuvant-containing composition" as used herein refers to a composition containing a known environmental improvement material, a known pesticide, or a known quarantine insecticide and an adjuvant. The form of the adjuvant-containing composition will depend on the form of the existing environmental improvement material, known pesticide, or known quarantine insecticide, but is generally a liquid form. The adjuvant-containing composition may also be a mixture of one or more existing environmental improvement materials.
The term "existing environmental improvement materials" in this specification refers to materials and chemicals that are already used in the livestock farming field for purposes such as disinfection, deodorization, cleaning, infection prevention, mold prevention, algae prevention, soil improvement, and purification for employees, livestock farming environments, and equipment.

(Adjuvant-containing composition)
The adjuvant-containing composition of the present invention contains a known environmental improvement material, a known pesticide, or a known insecticide for disease prevention, and an adjuvant, and uses fine fibers including microfibers having a fiber width on the micron order and nanofibers having a fiber width on the nanon order as the adjuvant.
Furthermore, when the adjuvant-containing composition is sprayed in a required location in a livestock barn or the like and dried at room temperature, a mesh region made of microfibers and nanofibers is formed in that location.
This will be explained in detail below.

(Microfibers with fiber widths on the micron order)
The fiber width of the microfiber is usually 1 to 100 μm, preferably 1 to 50 μm.
The fiber length of the microfibers is usually 500 μm to 10 mm, preferably 500 μm to 5 mm, and more preferably 1 mm or less.

The fiber width and fiber length of the microfibers described in this specification are values obtained by averaging the measurements of 10 randomly selected fibers using a microscope. Note that although the fiber width and fiber length of the microfibers are measured at the trunk portion of the fiber, these values are used as the measured fiber width and fiber length of the trunk portion of the fiber even when the microfiber exists alone as the trunk portion of the fiber, when the microfiber exists as the trunk portion of the fiber and ultrafine branched fibers branched from the trunk portion of the fiber, or when the microfiber exists as a composite of a large number of even finer branched fibers.
That is, the fiber width and fiber length of the fiber trunk portion are measured for the microfibers in the present invention, regardless of whether or not the fiber trunk portion has a branched structure. Furthermore, microfibers within the above fiber width and fiber length ranges can be used as microfibers, regardless of whether or not the fiber trunk portion has a branched structure.

Microfibers are derived from components such as cellulose (including microbial products), polysaccharides such as chitin and chitosan, proteins such as collagen and gelatin, polylactic acid, and polycaprolactam.

(Nanofibers with nano-order fiber width)
The fiber width of the nanofibers is usually 3 to 1000 nm, preferably 3 to 500 nm, and more preferably 3 to 200 nm.
The fiber length of the nanofibers is usually 200 nm to 2000 μm, preferably 1 to 1000 μm, and more preferably 5 to 500 μm.

The fiber width and fiber length of nanofibers described in this specification are values obtained by averaging the measurements of 10 randomly selected fibers using a microscope. Note that although the fiber width and fiber length of nanofibers are measured at the fiber trunk, these values are used as the measured fiber width and fiber length of the fiber trunk even when the nanofiber exists alone as the fiber trunk, when the nanofiber exists as a fiber trunk and ultrafine branched fibers branched from the fiber trunk, or when the nanofiber exists as a fiber trunk composed of many even fine branched fibers.
That is, the fiber width and fiber length of the fiber trunk portion are measured for the nanofibers of the present invention, regardless of whether or not the fiber trunk portion has a branched structure. Furthermore, nanofibers within the above fiber width and fiber length ranges can be used as nanofibers, regardless of whether or not the fiber trunk portion has a branched structure.

Like microfibers, nanofibers are derived from components such as cellulose (including microbial products), polysaccharides such as chitin and chitosan, proteins such as collagen and gelatin, polylactic acid, and polycaprolactam.

(Fine fibers)
For the production of polysaccharide fine fibers, reference can be made to the production method of fine fibers described in Japanese Patent No. 6,867,613, the preparation method of cellulose nanofibers and cellulose nanocrystal aqueous solutions using cellulose as a natural polymer described in Japanese Patent No. 6,704,551, and the production method of fine fibers derived from other raw materials described in both publications.
Furthermore, as the polysaccharide fine fibers that can be used in the present invention, derivatized CNF obtained by the method for producing derivatized CNF described in Japanese Patent No. 6245779 can also be used.

The raw material for the polysaccharide fine fibers may be one type alone or a mixture of two or more types. Furthermore, it is preferable to use pulp with an α-cellulose content of 60% to 99% by mass as the raw polysaccharide. If the purity is 60% or more by mass, it is easy to adjust the fiber diameter and length, and compared to when an α-cellulose content of less than 60% by mass is used, it has high thermal stability, good color inhibition, and is less likely to spoil. On the other hand, when an α-cellulose content of 99% or more by mass is used, it becomes difficult to defibrate the fibers to the nano-level.

Furthermore, in the present invention, plant residues and the like can be used as raw materials for the fine polysaccharide fibers. Examples of plant residues include bamboo skin; the skins of grapes, apples, mandarin oranges, sweet potatoes, etc.; tea leaves; coffee grounds; rice straw, wheat straw, rice husks; and animal droppings such as panda droppings. For example, when bamboo skin is used, it is expected to inactivate avian influenza, and it is possible to impart additional effects to the target agricultural substrate.

Using the ACC method (underwater counter-collision method) described in paragraph 0018 of Japanese Patent No. 6704551, CNFs with an average fiber width of 3 to 200 nm and an average fiber length of 0.1 μm or more can be obtained. The average fiber width and average fiber length are measured by appropriately selecting a microscope, such as a scanning electron microscope (SEM) or a transmission electron microscope (TEM), observing and measuring the CNFs, randomly selecting 10 fibers from the resulting photograph, and averaging these. A fluorescent microscope observation method utilizing fluorescence amplification may also be used.

In the present invention, cellulose nanofibers obtained by chemical treatments such as those using TEMPO oxidation catalysts, phosphate esterification, ozone treatment, enzyme treatment, maleic acid treatment, hydrophobic modification with alkenyl succinic anhydride, hydrophobic modification with alkyl ketene dimer, and hydrophobic modification by acetylation, which are known methods for producing fine fibers derived from other raw materials, can also be used as auxiliary agents in the present invention. Also, fine fibers obtained by physical methods that thin cellulosic fibers using wet grinding that utilizes mechanical action, such as grinders (stone mills), disk refiners, conical refiners, high-pressure homogenizers, bead mills, wet explosion, ultrasonic defibration, kneading, and freeze-grinding, can also be used as auxiliary agents in the present invention. Furthermore, fine fibers obtained by methods that combine chemical and physical treatments can also be used as auxiliary agents.

(Known environmental improvement materials)
The following are examples of known environmental improvement materials that are used for the purposes of disinfection, deodorization, cleaning, mildew prevention, algae prevention, soil improvement, purification, etc. The purpose of using known environmental improvement materials is to suppress the occurrence of viruses, fungi, bacteria, etc.
Examples of disinfectants include cationic soaps containing alkylpolyaminoethylglycine hydrochloride, didecyldimethylammonium chloride, and mono-bis(trimethylammonium chloride methylene-alkyl(C9,15)-toluene aqueous solution); and ionic surface-active substances such as amphoteric surfactants containing polyalkylpolyaminoethylglycine hydrochloride. Specific product names include Key Area A (San Chemifa Corporation), Astop 200, Astop, and Rontect (all from Scientific Feed Research Institute Co., Ltd.), Clear Keel 50 and Cathiodet DDC-AP (all from Tamura Pharmaceutical Co., Ltd.), Mitre, and Mitre Green (Yoichi Chemical Research Institute Co., Ltd.).
Additionally, halogen salt preparations containing iodine, such as chlorine-based, potassium hydrogen peroxomonosulfate, and sodium dichloroisocyanurate, are available. Specific product names include Antecvircon S (Bayer Yakuhin, Ltd.) and Jam Clear (Kyoritsu Seiyaku Co., Ltd.). Iodine compound preparations, such as Popyon Iodine and Nonoxynol Iodine, are also available. Specific product names include Neoyojin Liquid for Animals (Kyoritsu Seiyaku Co., Ltd.) and Iodip (Nippon Zenyaku Kogyo Co., Ltd.). Alcohol and aldehyde preparations containing compounds with an aldehyde group (-CHO), ethanol, isopropanol, and other ingredients are also available. Specific product names include Excut 25% SFL (Scientific Feed Research Institute Co., Ltd.) and Gluta Plus (Sumika Environmental Science Co., Ltd.). Polyup 16 (Aruka Animal Health Co., Ltd.) and Biocid 30 (Zoetis Japan Co., Ltd.) are also available.
Deodorizers include, for example, those that use a variety of lactic acid bacteria, those that use plant enzymes, and those that use humic acid or mineral components.

(known pesticides)
The known pesticides in the present invention are pesticides defined in Article 2, Paragraph 1 of the Agricultural Chemicals Control Act, including fungicides, insecticides, and other chemicals used to control bacteria, nematodes, mites, insects, rodents, and other animals, plants, or viruses that harm agricultural crops, as well as plant growth regulators, germination inhibitors, and other chemicals used to enhance or inhibit the physiological functions of agricultural crops, etc.
Examples of agricultural chemicals include insecticides, fungicides, insecticides and fungicides, herbicides, rodenticides, attractants, spreading agents, antimicrobial agents, and the like.

(known insecticides for disease prevention)
Known disease prevention insecticides include organophosphate insecticides such as diazinon, tolchlorfon, dichlorvos, fenitrothion, phthalthrin, d-d-T cyphenothrin, fenthion, and propetamphos, which are listed in the "List of Disease Prevention Insecticides on the Market" (Japan Disease Prevention Insecticide Association, revised August 12, 2020), chlorine-based insecticides such as orthodichlorobenzene, cresol, and propoxur, and imiprothrin, cyphenothrin, fenothrin, and joki. Examples include pyrethroid compounds such as daisy extract, pyrethrins, ddT-cyphenothrin, natural pyrethrins, permethrin, cypermethrin, tralomethrin, resmethrin, allethrin, furamethrin, transfluthrin, metofluthrin, profluthrin, and etofenprox; insect growth regulators such as pyriproxyfen and methoprene; and other insecticides such as indoxacarb, hydramethylnon, and dinotefuran.

Examples of the formulation of the epidemic prevention insecticide include emulsifiable concentrates, dusts, low-odor emulsions, wettable powders, water-soluble powders, flowable powders, MC formulations, oil solutions, and aqueous emulsions.

(Mesh region consisting of microfibers and nanofibers)
Using Figure 1, we will explain what it means that when the adjuvant-containing composition of the present invention is sprayed in a required location in a livestock barn or the like and dried at room temperature, a mesh region made of microfibers and nanofibers is formed in that location.
FIG. 1 shows the state of an auxiliary agent, which is assumed to contain multiple microfibers with a fiber length of 500 μm (the lower limit of the normal fiber length of nanofibers) and multiple nanofibers with a fiber length of 200 nm, sprayed in a desired location in a livestock barn or the like and then dried at room temperature. For ease of understanding, the fiber widths are assumed to be the same size. During the drying process, the auxiliary agent is fixed in place while entangled with the microfibers, or with the nanofibers, or with the nanofibers (represented by 1, 2, and 3 in FIG. 1). As a result, multiple regions surrounded by multiple microfibers are formed. Here, since the microfibers are sufficiently long compared to the nanofibers, single nanofibers or multiple entangled nanofibers exist within these regions (represented by 4 and 5 in FIG. 1).
From the above, the mesh region consisting of microfibers and nanofibers in the present invention is interpreted as a state in which, when the adjuvant-containing composition is in a dried state, there is a region (hereinafter sometimes referred to as a region) in which nanofibers having a fiber width of 3 to 1000 nm and a fiber length of 200 nm to 2000 μm are surrounded by microfibers having a fiber width of 1 to 100 μm and a fiber length of 500 μm to 10 mm.

Using Figure 2, we will explain how the mesh region consisting of microfibers and nanofibers is formed when the adjuvant-containing composition is dried, thereby enhancing the effectiveness of existing environmental improvement materials, existing pesticides, and existing disease prevention insecticides.
FIG. 2 is a diagram showing that active ingredients 6 such as existing environmental improvement materials, existing pesticides, or existing insecticides for disease prevention are fixed to the microfibers and nanofibers of FIG.
The size of fungi and bacteria targeted by environmental improvement materials, pesticides, etc. is approximately 3 to 40 μm for fungi and 0.5 to 10 μm for bacteria. Therefore, fungi and bacteria can exist in the area surrounded by nanofibers with a fiber width of 3 to 1,000 nm and a fiber length of 200 nm to 2,000 μm, which are surrounded by microfibers with a fiber width of 1 to 100 μm and a fiber length of 500 μm to 10 mm.
Therefore, if fungi or bacteria exist in this region, they will eventually die within this region. Because the active ingredient is present on the microfibers, they cannot cross the microfibers and undergo cell division. Furthermore, because the active ingredient is present in this region and is fixed to the nanofibers, fungi and bacteria are directly killed.
Furthermore, since the active ingredient is selectively fixed to the fibers, rather than being uniformly present over the entire area, the concentration of the active ingredient is locally high on the fibers, which enhances its effectiveness particularly against microorganisms.

Most pests targeted by agricultural insecticides or disease prevention insecticides are approximately 1 mm or larger in size. When an adjuvant-containing composition is sprayed on such pests, the fine fibers to which the active ingredient is attached can adhere and stick to the pest's body. This allows for more effective pest control than simply spraying the pest with an insecticide. This is because there is thought to be a significant difference in the amount of time the active ingredient remains on the pest's body surface when the insecticide is simply sprayed and when it is sprayed as an adjuvant-containing composition.

(Preparation of adjuvant-containing composition)
The method for preparing the adjuvant-containing composition is not particularly limited, but it is preferable to mix a dispersion containing polysaccharide fine fibers as an adjuvant with a known environmental improvement material, a known pesticide, or an insecticide for disease prevention. The dispersion containing polysaccharide fine fibers may be diluted to a predetermined concentration with a solvent (usually water) before use.
The amount of the diluted solution of the known environmental improvement material may be appropriately determined according to the instructions for use of the various environmental improvement materials to be used.
The amount of the diluted solution of the known pesticide may be appropriately determined according to the instructions in the instruction manual of the various environmental improvement materials to be used.
The amount of dilution of known epidemic prevention insecticides may be appropriately determined according to the instructions for use of the various epidemic prevention insecticides to be used.
The content of polysaccharide fine fibers in the adjuvant-containing composition is not particularly limited, but is preferably 0.001% by mass or more and 10% by mass or less. If the content of polysaccharide fine fibers is too low, the effects of environmental improvement materials and epidemic prevention insecticides cannot be improved. On the other hand, if the content is 10% by mass or more, the adjuvant-containing composition becomes highly viscous, which reduces sprayability and makes uniform spraying difficult.

(Method of using the adjuvant-containing composition)
The adjuvant-containing composition of the present invention is used by spraying or dispersing it in livestock barns or the like using a sprayer or the like. The adjuvant-containing composition of the present invention may be used by spraying a mixture in which the adjuvant is mixed with a known environmental improvement material, a known pesticide, or a known epidemic prevention insecticide in advance, or by spraying the adjuvant-containing composition at a target location and then subsequently spraying a known environmental improvement material or a known epidemic prevention insecticide. In this case, in addition to spraying on the ground, spraying from the air using a manned aircraft, helicopter, or unmanned radio-controlled helicopter may also be used.

The adjuvant-containing composition of the present invention, which uses fine fibers as an adjuvant for environmental improvement materials, uses polysaccharide fine fibers as a substance that improves the sustainability and other effects of various active ingredients in existing environmental improvement materials. In other words, the active ingredients are fixed to the fine fibers, or the fine fibers are fixed to the area where they are sprayed, preventing the environmental improvement material itself from running off.

The present invention will be explained below based on examples, but the present invention is not limited to these examples.

Examples 1 to 6
Bamboo pulp was used as a cellulose-derived component, and the defibration process was carried out using the ACC method (underwater counter collision method), to obtain an auxiliary agent (fine fiber content 2%) containing microfibers and nanofibers with a fiber width on the nano order.
Next, the resulting adjuvant and Mitre Green (active ingredient: China Blue; Yoichi Chemical Research Institute, Inc.), used as an environmental improvement material, were mixed to prepare an adjuvant-containing composition at the concentrations shown in Table 1. For example, when diluting a 2% concentration of fine fiber-containing material 40 times, 2% = 20 g/1,000 ml (= 20 μg/1 ml) is diluted 40 times, so the concentration is (20 ÷ 40) μg/ml = 0.5 μg/ml.
Next, the obtained adjuvant-containing composition was filtered using filter paper (Advantec Co., Ltd.; No. 1; diameter 90 mm).
Next, the filter paper after filtration was measured for the L value, a value, and b value in the Lab color system using a colorimeter ZE6000 (manufactured by Nippon Denshoku Industries Co., Ltd.) The measurement results are shown in Table 1.

(Reference examples 1 to 4)
Mitre Green (active ingredient: China Blue; Yojitsu Chemical Research Institute Co., Ltd.) was added to the solution to give the concentrations shown in Table 1 below.
Then, the mixture was filtered using filter paper (Advantec Co., Ltd.; No. 1; diameter 90 mm).
Next, the filter paper after filtration was measured for the L value, a value, and b value in the Lab color system using a colorimeter ZE6000 (manufactured by Nippon Denshoku Industries Co., Ltd.) The measurement results are shown in Table 1.

From Table 1, it can be seen that the results of combinations in which the concentration of the environmental improvement material was the same but the concentration of the fine fibers was different (Example 1 and Reference Example 1, Example 2 and Reference Example 2, Example 3 and Reference Example 3, and Example 4 and Reference Example 4) showed that the L value, a value, and b value in the Lab color system were all shifted in the negative direction, which can be interpreted as a darker color, and therefore it became clear that China blue was fixed to the fine fibers.
On the other hand, the results of combinations where the concentration of the environmental improvement material was the same but the amount of fine fiber was different (Example 3, Example 5, Example 6 and Reference Example 3) showed that the sum of the a and b values in the Lab color system tended not to increase even if the amount of fine fiber was increased beyond 1.0 μg/ml, and therefore it became clear that the effects of the auxiliary-containing composition of the present invention can be obtained if the concentration of fine fiber in the auxiliary-containing composition is 1.0 μg/ml.

Examples 7 to 12
The adjuvants used in Examples 1 to 6 and Mitre (active ingredients: gentian violet and methylene blue; Yojitsu Chemical Research Institute Co., Ltd.), which was used as an environmental improvement material, were mixed with water to give the concentrations shown in Table 2 below to prepare adjuvant-containing compositions.
Next, the obtained adjuvant-containing composition was filtered using filter paper (Advantec Co., Ltd.; No. 1; diameter 90 mm).
The transmittance of the filtrate at 400 nm was then measured using a spectrophotometer U-3900 (manufactured by Hitachi High-Technologies Corporation). The measurement results are shown in Table 2.

(Reference examples 5 to 8)
Mitre (active ingredients: gentian violet and methylene blue; Yojitsu Chemical Research Institute Co., Ltd.) was diluted with water to the concentrations shown in Table 2 below.
Then, the mixture was filtered using filter paper (Advantec Co., Ltd.; No. 1; diameter 90 mm).
The transmittance of the filtrate at 400 nm was then measured using a spectrophotometer U-3900 (manufactured by Hitachi High-Technologies Corporation). The measurement results are shown in Table 2.

From Table 2, it is clear that the transmittance values at 400 nm all increased for combinations with the same concentration of environmental improvement material but different concentrations of fine fibers (Example 7 and Reference Example 5, Example 8 and Reference Example 6, Example 9 and Reference Example 7, and Example 10 and Reference Example 8), which indicates that gentian violet and methylene blue were fixed to the fine fibers.
On the other hand, from the results of combinations in which the concentration of the environmental improvement material was the same but the concentration of the fine fibers was different (Examples 9, 11, 12 and Reference Example 7), the amount of the active ingredient adhered to the fine fibers was calculated as the difference in transmittance (for example, calculated as 82.3 (Example 9) - 78.9 (Reference Example 7)). Even if the amount of fine fibers was increased beyond 1.0 μg/ml, there was no tendency for the amount to increase, and it was therefore clear that the effect of the auxiliary-containing composition of the present invention can be obtained if the concentration of the fine fibers in the auxiliary-containing composition is 1.0 μg/ml.

Claims (8)

An adjuvant-containing composition containing an environmental improvement material used in the livestock farming field and an adjuvant, the adjuvant being an environmental improvement material used in the livestock farming field, the environmental improvement material using fine fibers consisting of microfibers having a fiber width of 1 to 100 μm and nanofibers having a fiber width of 3 to 1000 nm,
The environmental improvement material is an invert soap,
The adjuvant-containing composition, when dried at room temperature, forms a mesh region made of the fine fibers. 10. The adjuvant-containing composition of claim 1,
The adjuvant-containing composition wherein the cationic soap has didecyldimethylammonium chloride as an active ingredient. 10. The adjuvant-containing composition of claim 1,
The cationic soap is a composition containing an adjuvant, the active ingredient of which is mono-bis(trimethylammonium chloride methylene-alkyl-toluene). An adjuvant-containing composition containing an environmental improvement material used in the livestock farming field and an adjuvant, the adjuvant being an environmental improvement material used in the livestock farming field, the environmental improvement material using fine fibers consisting of microfibers having a fiber width of 1 to 100 μm and nanofibers having a fiber width of 3 to 1000 nm,
the environmental improvement material is an aldehyde preparation,
An adjuvant-containing composition, wherein a network region made of the fine fibers is formed when the adjuvant-containing composition is dried at room temperature. An adjuvant-containing composition containing an environmental improvement material used in the livestock farming field and an adjuvant, the adjuvant being an environmental improvement material used in the livestock farming field, the environmental improvement material using fine fibers consisting of microfibers having a fiber width of 1 to 100 μm and nanofibers having a fiber width of 3 to 1000 nm,
The environmental improvement material is a halogen salt preparation,
An adjuvant-containing composition, wherein a network region made of the fine fibers is formed when the adjuvant-containing composition is dried at room temperature. An adjuvant-containing composition containing a quarantine insecticide and an adjuvant, the adjuvant being made of fine fibers consisting of microfibers having a fiber width of 1 to 100 μm and nanofibers having a fiber width of 3 to 1000 nm,
The epidemic prevention insecticide is a chlorine-based insecticide,
The adjuvant-containing composition, when dried at room temperature, forms a mesh region made of the fine fibers. 7. The adjuvant-containing composition of claim 6,
The adjuvant-containing composition wherein the chlorine-based insecticide contains cresol as an active ingredient. 7. The adjuvant-containing composition of claim 6,
The adjuvant-containing composition wherein the chlorine-based insecticide contains orthodichlorobenzene as an active ingredient.