JP7795552B2 - New preservative system and cosmetic composition containing same - Google Patents

Description

CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of priority to U.S. Patent Application No. 17/218,797, filed March 31, 2021, entitled "A NEW PRESERVATIVE SYSTEM," and French Patent Application No. 2107903, filed July 22, 2021, the disclosures of which are incorporated by reference as if fully rewritten herein.

The present disclosure relates to an antiseptic system for keratinous tissue, particularly skin, comprising salicylic acid, benzoic acid or a salt thereof, and a divalent transition metal salt.

Preservatives are commonly used in personal care products. They aim to protect such products from spoilage or spoilage, primarily caused by microorganisms. They typically have antimicrobial activity.

Because preservatives can cause adverse effects such as allergic reactions and dermatitis, it is desirable to use them in the smallest amount possible in cosmetics or other personal care products. Therefore, a balance must be achieved by having an effective antimicrobial amount of the preservative or preservatives in the product, yet having as little amount as possible to avoid or reduce the chance of adverse effects. It is also desirable that the preservative or blend of preservatives be effective against the widest possible range of potentially harmful microorganisms that can cause spoilage or spoilage of the personal care product. Furthermore, such preservatives should be chemically and physically compatible with the other ingredients in the personal care product.

U.S. Patent Application Serial No. 17/218,797 French Patent Application No. 2107903

The present disclosure relates to preservative systems that are unique compared to known preservative systems because they are aimed at preserving highly natural formulations without the use of petrochemicals or alcohol, and are suitable for all product formats, including bottle packaging, which requires the most stringent level of challenge testing for products that are exposed to the most contact with the environment. Without wishing to be bound by any particular theory, the inventors believe that the combination of salicylic acid, benzoic acid, and one or more divalent metal salts contributes to the preservation of highly natural cosmetic systems. Preservative systems typically include:
Salicylic acid;
b. a weak organic acid or its salt;
c. Containing one or more divalent transition metal salts.

In some embodiments, the weak organic acid or its salt is selected from benzoic acid, sorbic acid, levulinic acid, anisic acid, dehydroacetic acid, propionic acid, and combinations thereof. In one embodiment, the weak organic acid or its salt is benzoic acid or its salt.

In some embodiments, the preservative system comprises one or more divalent metal salts selected from divalent metal salts of organic acids, divalent metal salts of inorganic acids, and combinations thereof.

In one or more embodiments, the one or more divalent metal salts are selected from salts of zinc, nickel, copper, silver, manganese, cobalt, and combinations thereof.

In some embodiments, the one or more divalent metal salts comprise a divalent metal salt of an organic acid selected from zinc lactate, zinc gluconate, zinc phenolsulfonate, zinc salicylate, zinc pyrrolidonecarboxylate (zinc PCA), zinc citrate, zinc ascorbate, copper gluconate, copper sulfate, salt derivatives thereof, and combinations thereof.

In some embodiments, the one or more divalent metal salts include divalent metal salts of inorganic acids selected from metal halides, metal hydroxides, metal sulfates, metal oxides, and combinations thereof. In one embodiment, the one or more divalent metal salts of inorganic acids are selected from salts of zinc, nickel, copper, silver, manganese, cobalt, and combinations thereof.

In some embodiments, the one or more divalent metal salts of an organic acid include a zinc salt. In one embodiment, the zinc salt is zinc gluconate.

In some different aspects of the present disclosure, some embodiments may include a cosmetic composition comprising a preservative system described herein, a suitable carrier system, and additives selected from fatty compounds, fillers, polymers, surfactants, solvents, essential oils, botanical extracts, conditioners, emollients, skin-care ingredients, thickeners, antioxidants, other preservatives, active ingredients, fragrances, and combinations thereof.

In one or more embodiments, the one or more divalent metal salts are present in an amount of from about 0.01 to about 0.5% by weight, based on the total weight of the cosmetic composition.

In one or more embodiments, salicylic acid is present in an amount of about 0.01 to about 0.5% by weight, based on the total weight of the cosmetic composition.

In some embodiments, benzoic acid is present in an amount of about 0.01 to about 0.3% by weight, based on the total weight of the cosmetic composition.

In one or more embodiments, the cosmetic composition is in the form of an oil-in-water emulsion. In one embodiment, the cosmetic composition is in the form of a water-in-oil emulsion.

In one or more embodiments, the preservative systems described in this disclosure may be used in hair compositions, skin care compositions, cleansing compositions, and makeup compositions.

The preservative system of the present disclosure contains salicylic acid, benzoic acid, and one or more divalent transition metal salts and can be added to other cosmetic compositions. The cosmetic composition may contain a solvent or any of the other components described herein below as components that can be added to compositions according to the present disclosure.

The compositions of the present disclosure can be prepared by mixing salicylic acid, benzoic acid, and a divalent metal salt. The solvent can be added after mixing, or the components can be mixed while still in the solvent. Other components can be added during or after mixing. The salicylic acid, benzoic acid, and divalent metal salt can also be added to a premix of the other components.

In one or more embodiments, the cosmetic composition may include a preservative system including salicylic acid, benzoic acid, one or more divalent transition metal salts, and several additives selected from fatty compounds, fillers, surfactants, solvents, essential oils, botanical extracts, conditioners, emollients, skin-care ingredients, thickeners, antioxidants, other preservatives, active ingredients, fragrances, and combinations thereof.

The novel features identified in the preservative system and described in this disclosure can be applied to any cosmetic product, particularly highly natural formulations. Highly natural formulations can be effectively preserved for all product formats and highly aqueous systems and emulsions. Cosmetic compositions containing the novel preservative system that are suitable for topical application to keratinous tissue, such as the skin, include compositions in the form of lotions, serums, gels, emulsions, liquid foundations, or creams.

Suitable cosmetic systems containing the novel preservative system include emulsions of liquid or semi-liquid consistency of the milky type, obtained by dispersing a fatty phase in an aqueous phase (O/W) or vice versa (W/O), including those using silicone and non-silicone oils, or suspensions or emulsions of soft consistency of the aqueous gel or cream type, or microcapsules or microparticles, or vesicular dispersions of the ionic and/or nonionic type or foam, of the lotion or serum type, or they can be provided in the form of a cosmetic liquid or micellar water, or they can be two-phase, containing water and other solvents, such as alcohols and other water-soluble solvents, and water-immiscible oils. Two-phase compositions require pre-application stirring to form an emulsion before application to keratinous tissue, such as the skin, which emulsion is of sufficient quality and stability to allow uniform application of the emulsified phase. Thus, suitable carrier systems according to the present disclosure may be selected from any one of oil-in-water emulsions, water-in-oil emulsions, silicone-in-water emulsions, dispersions, micellar water, two-phase compositions, and foams.

In one or more embodiments, the cosmetic composition can be in the form of an oil-in-water emulsion. In some embodiments, the cosmetic composition is in the form of a water-in-oil emulsion. In some embodiments, the cosmetic composition is an aqueous system, an aqueous serum, a gel, a light lotion, or a shampoo.

Another aspect of the present disclosure is a method for manufacturing a semiconductor device comprising:
a. 0.01 to 0.5% by weight of salicylic acid;
b. 0.01 to 0.3% by weight of benzoic acid or a salt thereof;
c. A composition having a preservative system comprising one or more divalent transition metal salts.

In some embodiments, some compositions include:
A) the following: a. 0.01 to 0.5% by weight of salicylic acid;
b. 0.01 to 0.3% by weight of benzoic acid or a salt thereof;
c. a preservative system comprising about 0.01 to about 0.5 wt. % of one or more divalent transition metal salts;
B) from about 0.1 to about 15% by weight of one or more fatty compounds;
C) about 0.1 to about 5 wt. % of one or more fillers;
D) about 0.1 to about 10% by weight of one or more surfactants;
E) a suitable carrier.

In another exemplary embodiment, the present disclosure relates to a method of preserving a composition by incorporating a preservative system described in the present disclosure.

These and other aspects of the present invention are set forth in the accompanying claims and are described in more detail in the detailed description.

This disclosure describes exemplary embodiments according to general inventive concepts and is not intended to limit the scope of the invention in any way. Indeed, the invention as described herein is broader than, and is not limited by, the exemplary embodiments shown herein, and terms used herein have their full ordinary meaning.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present disclosure.

The present disclosure relates to preservative systems that are unique compared to known preservative systems because they are aimed at preserving highly natural formulations without the use of petrochemicals or alcohol that are suitable for all product formats, including bottle packaging, which require the most stringent level of challenge testing for products exposed to the most contact with the environment.
Salicylic acid;
b. a weak organic acid or its salt;
c. Containing one or more divalent transition metal salts.

As used herein, the term "preservative system" or "preservative" is understood to refer to a preservative composition that includes ingredients that have both antimicrobial and antioxidant effects and that can be incorporated into cosmetic and personal care formulations, thereby improving the shelf life of such cosmetic and personal care formulations.

As used herein, the term "solubility" is understood to describe the ability to dissolve into a homogeneous solution without visible or microscopic cloudiness or particulate changes.

Salicylic Acid According to various embodiments, the preservative system according to the present disclosure includes salicylic acid.

Salicylic acid (derived from the Latin word salicylic acid, meaning "willow tree") is a lipophilic monohydroxybenzoic acid, a type of phenolic acid, and a beta-hydroxy acid (BHA). It has the formula C7H6O3. This colorless, crystalline organic acid is widely used in organic synthesis and functions as a plant hormone.

According to various embodiments, the amount of salicylic acid present in the preservative system ranges from 1.5 to about 95% by weight, or from about 2.0 to about 94.5% by weight, or from about 4.0 to about 91% by weight, or from about 5.0 to about 90% by weight, or from about 7.0 to about 89% by weight, or from about 10 to about 80% by weight, or from about 15 to about 75% by weight, based on the weight of the preservative system, or any suitable combination, subcombination, range, or sub-range thereof.

Thus, any one or combination of salicylic acids may be present in amounts, by weight, based on the total weight of the preservative system, including increments and ranges therein and therebetween, of about 1.5, 1.8, 2.0, 2.2, 2.4, 2.6, 2.8, 3.0, 3.2, 3.4, 3.6, 3.8, 4.0, 4.2, 4.4, 4.6, 4.8, 5.0, 5.2, 5.4, 5.6, 5.8, 6.0, 6.2, 6.4, 6.8, 7.0, 7.2, 7.4, 7.6, 7.8, 8.0, 8.2, 8.4, 8.6, 8.8, 9.0, 9.2, 9.4, 9.6, 9.8, 10.0, 12.0, 14.0, 16.0, 18.0, 19.0, 20.0, 21.0, 22.0, 23.0, 24.0, 25.0, 26.0, 27.0, 28.0, 29.0, 30.0, 31.0, 32.0, 33.0, 34.0, 35.0, 36.0, 37.0, 38.0, 39.0, 40.0, 41.0, 42.0, 43.0, 44.0, 45.0, 46.0, 47.0, 48.0, 49.0, 50.0, 51.0, 52.0, 53.0, 54.0, 55.0, 56. 0, 14.0, 16.0, 18.0, 20.0, 22.0, 24.0, 26.0, 28.0, 30.0, 32.0, 34.0, 36.0, 38.0, 40.0, 42.0, 44.0, 46.0, 48.0 to about 48.0, 50.0, 52.0, 54.0, 56.0, 58.0, 60.0, 62.0, 64.0, 66.0, 68.0, 70.0, 72.0, 74.0, 76.0, 78.0, 80.0, 82.0, 84.0, 86.0, 88.0, 90.0, 92.9, 92.0, 93.0, 94.0, or 95.0% is present.

According to various embodiments, the amount of salicylic acid present in the cosmetic composition is in the range of about 0.01 to about 0.5% by weight, or about 0.05 to about 0.48% by weight, or about 0.1 to about 0.46% by weight, or 0.15 to about 0.4% by weight, based on the weight of the composition, or any suitable combination, subcombination, range, or sub-range thereof.

Thus, any one or combination of salicylic acids may be present in an amount by weight, based on the total weight of the cosmetic composition, including increments and ranges therein and therebetween, of about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.11, 0.12, 0.13, 0.14, 0.15 to about 0.15, 0.16, 0.17, 0.18, Present at 0.19, 0.20, 0.21, 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, 0.3, 0.31, 0.32, 0.33, 0.34, 0.35, 0.36, 0.37, 0.38, 0.39, 0.4, 0.41, 0.42, 0.43, 0.44, 0.45, 0.46, 0.47, 0.48, 0.49, or 0.5% by weight.

Weak Organic Acids According to various embodiments, the preservative system according to the present disclosure includes a weak organic acid or a salt thereof.

According to various embodiments, the amount of weak organic acid or salt thereof present in the preservative system is in the range of about 1.5 to about 95% by weight, or about 2.0 to about 94.5% by weight, or about 4.0 to about 91% by weight, or about 5.0 to about 90% by weight, or about 7.0 to about 89% by weight, or about 10 to about 80% by weight, or about 15 to about 75% by weight, based on the weight of the preservative system, or any suitable combination, subcombination, range, or sub-range thereof.

Thus, any one or combination of weak organic acids or salts thereof may be present in an amount, by weight, based on the total weight of the preservative system, including increments and ranges therein and therebetween, of about 1.5, 1.8, 2.0, 2.2, 2.4, 2.6, 2.8, 3.0, 3.2, 3.4, 3.6, 3.8, 4.0, 4.2, 4.4, 4.6, 4.8, 5.0, 5.2, 5.4, 5.6, 5.8, 6.0, 6.2, 6.4, 6.8, 7.0, 7.2, 7.4, 7.6, 7.8, 8.0, 8.2, 8.4, 8.6, 8.8, 9.0, 9.2, 9.4, 9.6, 9.8, 10.0, 12.0, 14.0, 16.0, 18.0, 20.0, 22.0, 24.0, 26.0, 28.0, 30.0, 32.0, 34.0, 36.0, 38.0, 40.0, 42.0, 44.0, 46.0, 48.0 to about 48.0, 50.0, 52.0, 54.0, 56.0, 58.0, 60.0, 62.0, 64.0, 66.0, 68.0, 70.0, 72.0, 74.0, 76.0, 78.0, 80.0, 82.0, 84.0, 86.0, 88.0, 90.0, 92.9, 92.0, 93.0, 94.0, or 95.0% is present.

The weak organic acid may be selected from benzoic acid, sorbic acid, levulinic acid, anisic acid, dehydroacetic acid, propionic acid, and combinations thereof.

According to various embodiments, the amount of benzoic acid present in the preservative system is in the range of about 1.5 to about 95% by weight, or about 2.0 to about 94.5% by weight, or about 4.0 to about 91% by weight, or about 5.0 to about 90% by weight, or about 7.0 to about 89% by weight, or about 10 to about 80% by weight, or about 15 to about 75% by weight, based on the weight of the preservative system, or any suitable combination, subcombination, range, or sub-range thereof.

Thus, any one or combination of benzoic acid may be present in an amount, by weight, based on the total weight of the preservative system, including increments and ranges therein and therebetween, of about 1.5, 1.8, 2.0, 2.2, 2.4, 2.6, 2.8, 3.0, 3.2, 3.4, 3.6, 3.8, 4.0, 4.2, 4.4, 4.6, 4.8, 5.0, 5.2, 5.4, 5.6, 5.8, 6.0, 6.2, 6.4, 6.8, 7.0, 7.2, 7.4, 7.6, 7.8, 8.0, 8.2, 8.4, 8.6, 8.8, 9.0, 9.2, 9.4, 9.6, 9.8, 10.0, 12.0, 14.0, 16.0, 18.0, 19.0, 20.0, 21.0, 22.0, 23.0, 24.0, 25.0, 26.0, 27.0, 28.0, 29.0, 30.0, 31.0, 32.0, 33.0, 34.0, 35.0, 36.0, 37.0, 38.0, 39.0, 40.0, 41.0, 42.0, 43.0, 44.0, 45.0, 46.0, 47.0, 48.0, 49.0, 50.0, 51.0, 52.0, 53.0, 54.0, 55.0, 56. 0, 14.0, 16.0, 18.0, 20.0, 22.0, 24.0, 26.0, 28.0, 30.0, 32.0, 34.0, 36.0, 38.0, 40.0, 42.0, 44.0, 46.0, 48.0 to about 48.0, 50.0, 52.0, 54.0, 56.0, 58.0, 60.0, 62.0, 64.0, 66.0, 68.0, 70.0, 72.0, 74.0, 76.0, 78.0, 80.0, 82.0, 84.0, 86.0, 88.0, 90.0, 92.9, 92.0, 93.0, 94.0, or 95.0% is present.

According to various embodiments, the amount of weak organic acid present in the cosmetic composition is in the range of about 0.01 to about 0.3% by weight, or about 0.05 to about 0.28% by weight, or about 0.1 to about 0.2% by weight, or 0.15 to about 0.24% by weight, based on the weight of the composition, or any suitable combination, subcombination, range, or sub-range thereof.

Thus, any one or combination of weak organic acids is present in an amount by weight, based on the total weight of the cosmetic composition, of about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.11, 0.12, 0.13, 0.14, 0.15 to about 0.15, 0.16, 0.17, 0.18, 0.19, 0.20, 0.21, 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, or 0.3%, including increments and ranges therein and therebetween.

Divalent Transition Metal Salt According to various embodiments, the amount of divalent transition metal salt present in the preservative system is in the range of about 1.5 to about 95% by weight, or about 2.0 to about 94.5% by weight, or about 4.0 to about 91% by weight, or about 5.0 to about 90% by weight, or about 7.0 to about 89% by weight, or about 10 to about 80% by weight, or about 15 to about 75% by weight, based on the weight of the preservative system, or any suitable combination, subcombination, range, or sub-range thereof.

Thus, any one or combination of divalent transition metal salts may be present in an amount, by weight, based on the total weight of the preservative system, including increments and ranges therein and therebetween, of about 1.5, 1.8, 2.0, 2.2, 2.4, 2.6, 2.8, 3.0, 3.2, 3.4, 3.6, 3.8, 4.0, 4.2, 4.4, 4.6, 4.8, 5.0, 5.2, 5.4, 5.6, 5.8, 6.0, 6.2, 6.4, 6.8, 7.0, 7.2, 7.4, 7.6, 7.8, 8.0, 8.2, 8.4, 8.6, 8.8, 9.0, 9.2, 9.4, 9.6, 9.8, 10.0, 11.0, 12.0, 13.0, 14.0, 15.0, 16.0, 17.0, 18.0, 19.0, 20.0, 21.0, 22.0, 23.0, 24.0, 25.0, 26.0, 27.0, 28.0, 29.0, 30.0, 31.0, 32.0, 33.0, 34.0, 35.0, 36.0, 37.0, 38.0, 39.0, 40.0, 41.0, 42.0, 43.0, 44.0, 45.0, 46.0, 47.0, 48.0, 49.0, 50.0, 51.0, 5 2.0, 14.0, 16.0, 18.0, 20.0, 22.0, 24.0, 26.0, 28.0, 30.0, 32.0, 34.0, 36.0, 38.0, 40.0, 42.0, 44.0, 46.0, 48.0 to about 48.0, 50.0, 52.0, 54.0, 56.0, 58.0, 60.0, 62.0, 64.0, 66.0, 68.0, 70.0, 72.0, 74.0, 76.0, 78.0, 80.0, 82.0, 84.0, 86.0, 88.0, 90.0, 92.9, 92.0, 93.0, 94.0, or 95.0% is present.

According to various embodiments, the amount of divalent metal salt present in the cosmetic composition is in the range of about 0.01 to about 0.5% by weight, or about 0.05 to about 0.48% by weight, or about 0.1 to about 0.46% by weight, or 0.15 to about 0.44% by weight, based on the weight of the composition, or any suitable combination, subcombination, range, or sub-range thereof.

Thus, any one or combination of divalent metal salts may be present in an amount by weight, based on the total weight of the cosmetic composition, including increments and ranges therein and therebetween, of about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.11, 0.12, 0.13, 0.14, 0.15 to about 0.15, 0.16, 0.17, 0.18, Present at 0.19, 0.20, 0.21, 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, 0.3, 0.31, 0.32, 0.33, 0.34, 0.35, 0.36, 0.37, 0.38, 0.39, 0.4, 0.41, 0.42, 0.43, 0.44, 0.45, 0.46, 0.47, 0.48, 0.49, or 0.5% by weight.

Divalent Metal Salts of Inorganic Acids The one or more divalent metal salts of an inorganic acid may be selected from metal halides, metal hydroxides, metal sulfates, metal oxides, and combinations thereof.

Suitable examples of one or more divalent metal salts of an inorganic acid are selected from zinc chloride, zinc sulfate, zinc nitrate, zinc carbonate and zinc bicarbonate, zinc phosphate, and combinations thereof.

According to various embodiments, the amount of divalent metal salt of an inorganic acid present in the preservative system is in the range of about 1.5 to about 95% by weight, or about 2.0 to about 94.5% by weight, or about 4.0 to about 91% by weight, or about 5.0 to about 90% by weight, or about 7.0 to about 89% by weight, or about 10 to about 80% by weight, or about 15 to about 75% by weight, based on the weight of the preservative system, or any suitable combination, subcombination, range, or sub-range thereof.

Thus, any one or combination of divalent transition metal salts of inorganic acids may be present in an amount, by weight, based on the total weight of the preservative system, including increments and ranges therein and therebetween, of about 1.5, 1.8, 2.0, 2.2, 2.4, 2.6, 2.8, 3.0, 3.2, 3.4, 3.6, 3.8, 4.0, 4.2, 4.4, 4.6, 4.8, 5.0, 5.2, 5.4, 5.6, 5.8, 6.0, 6.2, 6.4, 6.8, 7.0, 7.2, 7.4, 7.6, 7.8, 8.0, 8.2, 8.4, 8.6, 8.8, 9.0, 9.2, 9.4, 9.6, 9.8, 10.0, 11.0, 12.0, 13.0, 14.0, 15.0, 16.0, 17.0, 18.0, 19.0, 20.0, 21.0, 22.0, 23.0, 24.0, 25.0, 26.0, 27.0, 28.0, 29.0, 30.0, 31.0, 32.0, 33.0, 34.0, 35.0, 36.0, 37.0, 38.0, 39.0, 40.0, 41.0, 42.0, 43.0, 44.0, 45.0, 46.0, 47.0, 48.0, 49.0, 50.0, 51.0 , 12.0, 14.0, 16.0, 18.0, 20.0, 22.0, 24.0, 26.0, 28.0, 30.0, 32.0, 34.0, 36.0, 38.0, 40.0, 42.0, 44.0, 46.0, 48.0 to about 48.0, 50.0, 52.0, 54.0, 56.0, 58.0, 60.0, 62.0, 64.0, 66.0, 68.0, 70.0, 72.0, 74.0, 76.0, 78.0, 80.0, 82.0, 84.0, 86.0, 88.0, 90.0, 92.9, 92.0, 93.0, 94.0, or 95.0% is present.

According to various embodiments, the amount of divalent metal salt of an inorganic acid present in the cosmetic composition is in the range of about 0.01 to about 0.5% by weight, or about 0.05 to about 0.48% by weight, or about 0.1 to about 0.46% by weight, or 0.15 to about 0.44% by weight, based on the weight of the composition, or any suitable combination, subcombination, range, or sub-range thereof.

Thus, any one or combination of divalent metal salts of inorganic acids may be present in an amount by weight, based on the total weight of the cosmetic composition, including increments and ranges therein and therebetween, of from about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.11, 0.12, 0.13, 0.14, 0.15 to about 0.15, 0.16, 0.17, 0.18, 0.19, 0.20, 0.21, 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, 0.30, 0.31, 0.32, 0.33, 0.34, 0.35, 0.36, 0.37, 0.38, 0.39, 0.40, 0.41, 0.42, 0.43, 0.44, 0.45, 0.46, 0.47, 0.48, 0.49, 0.50, 0.51, 0.52, 0.53, 0.54, 0.55, 0.56, 0.57, 0.58, 0.59, 0.60, 0.61, 0.62, 0.63, 0.64, 0.65, 0.66, 0.67, 0.68, 0.69, 0.70, 0.71, 0.72, 0.73, 0.74, 0.75, 0 , 0.19, 0.20, 0.21, 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, 0.3, 0.31, 0.32, 0.33, 0.34, 0.35, 0.36, 0.37, 0.38, 0.39, 0.4, 0.41, 0.42, 0.43, 0.44, 0.45, 0.46, 0.47, 0.48, 0.49, or 0.5% by weight.

Divalent Metal Salts of Organic Acids The one or more divalent metal salts of an organic acid may be selected from metal salts wherein the organic acid is selected from C1 to C9 monocarboxylic or dicarboxylic acids, polycarboxylic acids, hydroxycarboxylic acids, and fatty acids having at least 10 carbon atoms such as ascorbic acid, formic acid, acetic acid, glycolic acid, gluconic acid, lactic acid, mandelic acid, oxalic acid, maleic acid, malonic acid, glyoxylic acid, succinic acid, adipic acid, fumaric acid, sebacic acid, citric acid, tartaric acid, malic acid, 2-hydroxymalonic acid, 2-hydroxyl n-butyl 1,2,4-tricarboxylic acid, glutaric acid, glucaric acid, 2-hydroxy n-butyl 1,3,4-tricarboxylic acid, pyrrolidonecarboxylic acid, and phenolsulfonic acid.

In some embodiments, the one or more divalent metal salts of an organic acid are selected from zinc lactate, zinc gluconate, zinc phenolsulfonate, zinc salicylate, zinc pyrrolidonecarboxylate (zinc PCA), zinc ascorbate, zinc citrate, salt derivatives thereof, and combinations thereof.

In one embodiment, the one or more divalent metal salts of an organic acid include a zinc salt.

In one embodiment, the zinc salt is zinc gluconate.

According to various embodiments, the amount of divalent metal salt of an organic acid present in the preservative system is in the range of about 1.5 to about 95% by weight, or about 2.0 to about 94.5% by weight, or about 4.0 to about 91% by weight, or about 5.0 to about 90% by weight, or about 7.0 to about 89% by weight, or about 10 to about 80% by weight, or about 15 to about 75% by weight, based on the weight of the preservative system, or any suitable combination, subcombination, range, or sub-range thereof.

Thus, any one or combination of divalent transition metal salts of organic acids may be present in an amount, by weight, based on the total weight of the preservative system, including increments and ranges therein and therebetween, of about 1.5, 1.8, 2.0, 2.2, 2.4, 2.6, 2.8, 3.0, 3.2, 3.4, 3.6, 3.8, 4.0, 4.2, 4.4, 4.6, 4.8, 5.0, 5.2, 5.4, 5.6, 5.8, 6.0, 6.2, 6.4, 6.8, 7.0, 7.2, 7.4, 7.6, 7.8, 8.0, 8.2, 8.4, 8.6, 8.8, 9.0, 9.2, 9.4, 9.6, 9.8, 10.0, 11.0, 12.0, 13.0, 14.0, 15.0, 16.0, 17.0, 18.0, 19.0, 20.0, 21.0, 22.0, 23.0, 24.0, 25.0, 26.0, 27.0, 28.0, 29.0, 30.0, 31.0, 32.0, 33.0, 34.0, 35.0, 36.0, 37.0, 38.0, 39.0, 40.0, 41.0, 42.0, 43.0, 44.0, 45.0, 46.0, 47.0, 48.0, 49.0, 50.0, 51.0 , 12.0, 14.0, 16.0, 18.0, 20.0, 22.0, 24.0, 26.0, 28.0, 30.0, 32.0, 34.0, 36.0, 38.0, 40.0, 42.0, 44.0, 46.0, 48.0 to about 48.0, 50.0, 52.0, 54.0, 56.0, 58.0, 60.0, 62.0, 64.0, 66.0, 68.0, 70.0, 72.0, 74.0, 76.0, 78.0, 80.0, 82.0, 84.0, 86.0, 88.0, 90.0, 92.9, 92.0, 93.0, 94.0, or 95.0% is present.

According to various embodiments, the amount of divalent metal salt of an organic acid present in the cosmetic composition is in the range of about 0.01 to about 0.5% by weight, or about 0.05 to about 0.48% by weight, or about 0.1 to about 0.46% by weight, or 0.15 to about 0.44% by weight, based on the weight of the composition, or any suitable combination, subcombination, range, or sub-range thereof.

Thus, any one or combination of divalent metal salts of organic acids may be present in an amount by weight, based on the total weight of the cosmetic composition, including increments and ranges therein and therebetween, of from about 0.01, 0.02, 0.03, 0.04, 0.05, 0.06, 0.07, 0.08, 0.09, 0.10, 0.11, 0.12, 0.13, 0.14, 0.15 to about 0.15, 0.16, 0.17, 0.18, 0.19, 0.20, 0.21, 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, 0.30, 0.31, 0.32, 0.33, 0.34, 0.35, 0.36, 0.37, 0.38, 0.39, 0.40, 0.41, 0.42, 0.43, 0.44, 0.45, 0.46, 0.47, 0.48, 0.49, 0.50, 0.51, 0.52, 0.53, 0.54, 0.55, 0.56, 0.57, 0.58, 0.59, 0.60, 0.61, 0.62, 0.63, 0.64, 0.65, 0.66, 0.67, 0.68, 0.69, 0.70, 0.71, 0.72, 0.73, 0.74, 0.75, 0 Present at 0.8, 0.19, 0.20, 0.21, 0.22, 0.23, 0.24, 0.25, 0.26, 0.27, 0.28, 0.29, 0.3, 0.31, 0.32, 0.33, 0.34, 0.35, 0.36, 0.37, 0.38, 0.39, 0.4, 0.41, 0.42, 0.43, 0.44, 0.45, 0.46, 0.47, 0.48, 0.49, or 0.5% by weight.

Additives Optional Additives The composition may also comprise at least one additive conventionally used in the cosmetics field, which does not affect the properties of the composition according to the invention, such as thickeners, pearlescent agents, preservatives, sunscreens, anionic or cationic or amphoteric polymers, proteins, protein hydrolysates, fatty acids, silicones, vegetable, mineral or synthetic oils, gelling agents, fragrances, fillers, screening agents, odor absorbers and colorants.

Any one or combination of additives may be present in the composition according to the present invention in a proportion that is preferably, but not limited to, 0% to 90% by weight, or 1 to 90% by weight, relative to the total weight of the cosmetic composition.

Formulations Comprising the Composition Generally, any composition of the present invention can be applied topically to the skin (over any skin area of the body) or to mucous membranes (oral, buccal, gingival, conjunctival, etc.). Depending on the method of administration under consideration, the composition can be provided in any commonly used dosage form.

For topical application to the skin, the compositions may be in the form of emulsions of a liquid or semi-liquid consistency of the milky type, obtained by dispersion of a fatty phase in an aqueous phase (O/W) or vice versa (W/O), in particular aqueous or oily solutions or those using silicone and non-silicone oils; lotion- or serum-type dispersions; suspensions or emulsions of a soft consistency of the aqueous gel or cream type; microcapsules or microparticles; or vesicular dispersions of the ionic and/or non-ionic type or foam; or they may be provided in the form of a cosmetic liquid or micellar water; or they may be two-phase, containing water and other solvents, such as alcohols and water-soluble solvents, and water-immiscible oils. Two-phase compositions require pre-application stirring to form an emulsion before application to keratinous tissue, such as the skin, which emulsion is of sufficient quality and stability to allow uniform application of the emulsified phase. Thus, suitable carrier systems according to the present disclosure may be selected from any one of oil-in-water emulsions, water-in-oil emulsions, silicone-in-water emulsions, dispersions, micellar water, two-phase compositions, and foams. These compositions are prepared according to conventional methods.

The amounts of the various components of the composition according to the invention are those conventionally used in the field under consideration.

In the cosmetic field, these compositions in particular constitute creams for cleaning, protecting, treating or caring for the face, hands, feet, major anatomical folds or body (e.g. day creams, night creams, make-up remover creams, foundation creams or sunscreen creams), liquid foundations for caring for the skin, make-up remover emulsions, protective or caring body emulsions, sunscreen emulsions, lotions, gels or foams, in particular for the face, hands, feet, major anatomical folds or body, such as cleansing lotions, sunscreen lotions, artificial tanning lotions, bath compositions, deodorising compositions containing disinfectants, aftershave gels or lotions, depilatory creams, compositions for combating insect bites or stings, analgesic compositions or compositions for treating one or more of the following skin conditions: aging, sun damage, oily and acne-prone skin, and certain skin diseases, such as dermatitis, rosacea, psoriasis, lichen and severe prurigo.

Suitable Carriers: Water and/or glycols in the composition typically form part or all of the cosmetically acceptable carrier. Cosmetically acceptable carriers can include, for example, glycerin, C1-4 alcohols, organic solvents, fatty alcohols, fatty ethers, fatty esters, polyols, glycols, vegetable oils, mineral oils, liposomes, lamellar lipid materials, water, or any combination thereof. Examples of organic solvents include, but are not limited to, monoalcohols and polyols such as ethyl alcohol, isopropyl alcohol, propyl alcohol, benzyl alcohol, and phenylethyl alcohol, or glycols or glycol ethers such as the monomethyl, monoethyl, and monobutyl ethers of ethylene glycol, propylene glycol, or its ethers, such as the monomethyl ether of propylene glycol, butylene glycol, hexylene glycol, and dipropylene glycol, as well as alkyl ethers of diethylene glycol, such as the monoethyl ether or monobutyl ether of diethylene glycol. Other suitable examples of organic solvents include ethylene glycol, propylene glycol, butylene glycol, hexylene glycol, propanediol, and glycerin. The organic solvent can be a volatile or non-volatile compound.

In some cases, the cosmetically acceptable carrier may include water, a mixture of water and at least one cosmetically acceptable organic solvent, or at least one cosmetically acceptable organic solvent. Additionally, the cosmetically acceptable carrier may be or include ethanol, glycol ethers such as dipropylene glycol n-butyl ether, isododecane, mineral oil, propylene glycol, pentylene glycol, hexylene glycol, glycerol, and mixtures thereof.

According to various embodiments, water is present in the composition in a range from about 35% to about 90%, and in some embodiments from about 35% to about 70%, and in some embodiments from about 35% to about 65%, and in some embodiments from about 35% to about 60%, and in some embodiments about 68%, by weight based on the weight of the composition, or any suitable combination, subcombination, range, or sub-range thereof. However, one of ordinary skill in the art will appreciate that other ranges are within the scope of the present invention. Thus, water is present from about 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75 to about 90 percent by weight, including increments and ranges therein, based on the total weight of the composition. However, one of ordinary skill in the art will appreciate that other ranges are within the scope of the present invention.

The water used may be sterilized demineralized water and/or floral waters such as rose water, cornflower water, chamomile water or lime water, and/or waters from, for example, Vittel, Vichy waterfall, Uriage, La Roche Posay, La Bourboule, Enghien-les-Bains, Saint Gervais-les-Bains, Néris-les-Bains, Allévar-les-Bains, Digne, Maizieres, Neyrac-les-Bains, Lons-le-Saunier, Eaux Bonnes, Rochefort, Saint-Jean-de-France ... The water phase may be natural spring water or mineral water, such as water from Christau, water from Les Fumades, water from Tercis-les-Bains, or water from Avenè. The water phase may also include reconstituted spring water, i.e., water that contains trace elements such as zinc, copper, magnesium, etc., to reconstitute the characteristics of spring water.

The pH of the composition is generally, but not limited to, about 2.0 to about 7.0, and in some embodiments, about 3 to about 4.5. The pH can be adjusted to the desired value by adding a base (organic or inorganic) to the composition, such as sodium citrate, ammonia, or a primary, secondary, or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, or 1,3-propanediamine, or alternatively by adding an inorganic or organic acid, preferably a carboxylic acid, such as citric acid.

The pH of the composition is generally, but not limited to, 3.5 or higher. The pH can be adjusted to the desired value by adding a base (organic or inorganic) to the composition, such as ammonia or a primary, secondary, or tertiary (poly)amine, such as monoethanolamine, diethanolamine, triethanolamine, isopropanolamine, or 1,3-propanediamine, sodium hydroxide, potassium hydroxide, or alternatively by adding an inorganic or organic acid, preferably a carboxylic acid, such as citric acid.

In some embodiments, the composition includes one or more solvents, including an alcohol to solubilize the acid, such as a monoalcohol, such as a monohydric C1-C8 alcohol, for example, ethanol, propanol, butanol, isopropanol, isobutanol, and benzyl alcohol, and phenylethyl alcohol. In some embodiments, the alcohol solvent is selected from one or a combination of ethanol and isopropyl alcohol. The solvent may also include a water-soluble solvent, such as a polyol and a short-chain monoalcohol. In some specific embodiments, the water-soluble solvent is selected from glycerin, propylene glycol, butylene glycol, and combinations thereof. In one example, the solvent used in accordance with the present disclosure is propylene glycol.

According to various embodiments, the amount of alcohol or glycol present in the composition ranges from about 5% to about 20%, or from about 6% to about 18%, or from about 10% to about 15%, by weight, based on the weight of the composition, or any suitable combination, subcombination, range, or sub-range thereof. However, one of ordinary skill in the art will appreciate that other ranges are within the scope of the present invention.

Thus, any one or combination of alcohols or glycols may be present in an amount of about 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 to about 20 weight percent, including increments and ranges therein and therebetween, based on the total weight of the composition.

Optional Antioxidants The composition can also contain one or more antioxidants. The antioxidant can be any antioxidant or other additive suitable for use in cosmetic formulations. Suitable additives include, but are not limited to, resveratrol, tannic acid, polyphenols, amino acids and their derivatives, imidazole, peptides and derivatives such as carnosine, carotenoids, additional acids selected from carotenes (such as alpha-carotene, beta-carotene, and lycopene), alpha-hydroxy acids (such as citric acid, lactic acid, malic acid, and combinations thereof), beta-hydroxy acids (such as propionic acid, beta-hydroxybutyric acid, beta-hydroxybeta-methylbutyric acid, carnitine, and combinations thereof), tocopherol and derivatives (such as vitamin E), vitamin A, coenzyme Q10, bioflavonoids, glutathione, plant extracts (rosemary extract, olive leaf extract, Scutellaria baicalensis (baicalin), and mango leaf extract (mangiferin)), and green tea extract.

The amount of antioxidant present in the composition can range from about 0.01% to about 20%, or from about 0.1% to about 20%, or from about 0.01% to about 10%, based on the total weight of the composition.

Although the optional additives are provided as examples, it will be appreciated that other optional components that are suitable and compatible with cosmetic applications known in the art may be used.

In some specific embodiments, the composition may contain optional additives selected from terephthalylidene dicamphorsulfonic acid, trisodium ethylenediaminedisuccinate, sodium citrate, sodium chloride, hydroxyacetophenone sodium benzoate, potassium sorbate, citric acid, caprylyl glycol, and trisodium ethylenediaminedisuccinate, and combinations thereof.

According to various embodiments, when present in a composition according to the present disclosure, the amount of one or more actives and additives, alone or in combination, can be present in a range of about 0.001% to about 20%, and in some embodiments, about 0.05% to about 0.01%, and in some embodiments, 0.01% to about 0.1%, and in some embodiments, about 0.15% to about 5%, and in some embodiments, about 0.40% to about 4%, and in some embodiments, about 0.5% to about 2.5%, and in some embodiments, about 0.1% to about 0.5%, and in some embodiments, about 1% to about 2%, by weight based on the weight of the composition, or any suitable combination, subcombination, range, or sub-range thereof. However, one of ordinary skill in the art will appreciate that other ranges are within the scope of the present invention.

Practices of the present disclosure are provided by the following examples, which serve to clarify aspects of the technology without being limiting in nature.

Example 1
(Inventive Composition)

Example 2
Stability and Microbial Challenge Evaluation
The inventive and comparative compositions were evaluated for stability and microbial challenge testing. Efficacy was assessed against a broad spectrum of microorganisms following a challenge testing protocol similar to the PCPC gas line.

Results As shown by the results in Table 2, the use of salicylic acid and benzoic acid alone as preservatives was not strong enough to reduce E. faecalis (a gram-positive bacteria) in the formulation. Typical preservatives for the requisite log reduction of gram-positive bacteria include chlorphenesin and phenoxyethanol; however, these are petrochemical-based preservatives and do not meet the needs of highly natural formulations. Alcohol and capryloyl salicylic acid are also beneficial for preservation, but alcohol-free formulations are desirable, and capryloyl salicylic acid can cause instability in formulations, even at low levels.

The addition of transition metal 2+ ions, such as copper and zinc, was tested to provide additional microbial protection against gram-positive bacteria. When copper gluconate was added to the composition, a blue-greenish tint was observed. Such color was undesirable for the formulation. This was addressed by using an alternative transition metal 2+ ion, namely, zinc, which is colorless. Zinc salts are typically used for their anti-acne and anti-seborrheic properties. These properties motivated trials to include zinc gluconate and zinc PCA in formulations requiring additional strength against gram-positive bacteria, as bacteria are a common cause of acne. Gluconate is also beneficial for hydration by being a skin conditioner, which led to a focus on zinc gluconate as a preservative additive for the present disclosure.

The goal of this disclosure was to provide preservation in non-protective packaging, such as jars, for highly natural formulations without the use of alcohol or petrochemical-based preservatives, and to provide stable formulations for highly sensitive compositions.

Stable compositions were demonstrated by Inventive Example 1, Inventive Example 2, Inventive Example 3, and Inventive Example 4. These compositions contained the preservative system described in this disclosure. These Inventive Examples passed microbiological testing, as shown in Table 2.

Different preservative systems were also tested. For example, Comparative Examples 1, 2, 3, and 4 were prepared similarly to the inventive examples except that one or two of the components of the preservative system were absent. It was observed that when only salicylic acid and benzoic acid were present, the microbiological tests failed (i.e., Comparative Examples 2, 3, and 4). In the case of Comparative Example 1, where the preservative system contained salicylic acid and copper gluconate, the microbiological tests were borderline and therefore unacceptable.

Other comparative examples were tested without divalent metal salts (i.e., Comparative Example 5, Comparative Example 6, Comparative Example 7, Comparative Example 8, Comparative Example 9). Although some passed microbiological testing (i.e., Comparative Example 5, Comparative Example 6, Comparative Example 7, Comparative Example 8), the compositions were not stable and/or exhibited an undesirable texture. These results demonstrate the criticality of the preservative system. For example, in Comparative Example 5, the preservative system of the composition contained 0.1% salicylic acid and 0.15% benzoic acid along with 3.5% denatured alcohol; despite successful microbiological testing, the composition was not stable and emulsion separation was observed.

In the cases of Comparative Examples 10 and 11, the use of capryloyl salicylic acid resulted in an unstable formulation with emulsion separation.

In the case of Comparative Example 5, the use of denatured alcohol provided non-protective packaging that passed microbial testing, but resulted in undesirable aesthetics by having a glossy surface that appeared to lead to emulsion separation after two weeks at 45°C.

In the cases of Comparative Examples 6, 7, and 8, the use of chlorphenesin (a known non-natural preservative) provided non-protective packaging that passed the microbial challenge test, but the use of this material was undesirable due to the high natural content of the formulation and loss of mousse-like texture and glossy surface appearance after two weeks of stability. Furthermore, chlorphenesin is also a petrochemical-derived preservative that was undesirable for the formulation.

In the case of Comparative Example 9, the use of unnatural phenoxyethanol resulted in an unstable formulation due to emulsion separation.

As shown by the results in Table 2, the examples of the present invention demonstrated the microbial preservation of Gram-positive bacteria by an antiseptic system composed of salicylic acid, benzoic acid, and transition metal 2+ ions such as copper and zinc.

While the present disclosure has been described in terms of the described embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the present disclosure. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the present disclosure without departing from its essential scope. Therefore, the present disclosure is not limited to the particular embodiment disclosed as the best mode contemplated for carrying out the disclosure, but rather, the present disclosure is intended to include all embodiments falling within the scope of the appended claims.

The articles "a" and "an," as used herein, mean one or more when applied to any feature in the embodiments of the present disclosure described in the specification and claims. The use of "a" and "an" does not limit the meaning to just one feature unless such a limitation is specifically stated. The article "the" preceding a singular or plural noun or noun phrase refers to the particular specified feature (singular) or the particular specified features (plural) and may have a singular or plural connotation depending on the context in which it appears.

"At least one," as used herein, means one or more, and thus includes individual components as well as mixtures/combinations.

The transitional terms "comprising," "consisting essentially of," and "consisting of," when used in the appended claims, in their original and amended forms, define the scope of the claim in terms of which additional, unrecited claim elements or steps, if any, are excluded from the scope of the claim. The term "comprising" is intended to be inclusive or open-ended and does not exclude any additional, unrecited elements, methods, steps, or materials. The term "consisting of" excludes any elements, steps, or materials other than those specified in the claim and, in the latter case, impurities normally associated with the specified material. The term "consisting essentially of" limits the scope of the claim to the specified elements, steps, or materials and those that do not materially affect the basic and novel characteristics of the claimed disclosure. All materials and methods described herein that embody the present disclosure may, in alternative embodiments, be more specifically defined by any of the transition terms "comprising," "consisting essentially of," and "consisting of."

The terms "free" and "devoid" indicate that no reliably measurable excluded material is present in the composition, typically 0% by weight, based on the total weight of the composition. The term "essentially free" indicates that the excluded material is preferably not present in the composition, although very small amounts of the excluded material can be present in the compositions of the present invention, provided that these amounts do not substantially affect the advantageous properties of the composition. In particular, "essentially free" means that the excluded material can be present in the composition in an amount less than about 0.1% by weight, based on the total weight of the composition.

Other than in the examples, or where specifically indicated, all numbers expressing amounts of ingredients and/or reaction conditions should be understood to be modified in all instances by the term "about," meaning within 10% of the stated number (e.g., "about 10%" means 9%-11%, "about 2%" means 1.8%-2.2%).

All percentages and ratios are calculated by weight unless otherwise specified. All percentages are calculated based on the total composition unless otherwise specified. Generally, unless expressly stated otherwise, "weight" or "amount," as used herein in reference to the percent amount of an ingredient, refers to the amount of raw material that comprises the ingredient, where the ingredient may be described herein as containing less than 100% active of the ingredient. Thus, the weight percent of an active in a composition is expressed as the amount of the active-containing raw material used and may or may not reflect the final percentage of the active, where the final percentage of the active is dependent on the weight percent of the active in the raw material.

The terms "weight percent" and "weight %" may be used interchangeably and mean percent by weight, based on the total weight of a composition, article, or material, except as may be specified, for example, with respect to a component phase or system of the composition, article, or material. Ranges and amounts given herein are intended to include subranges and amounts using any disclosed endpoints. Thus, a range of "1% to 10%, such as 3% to 5%, such as 2% to 8%" is intended to encompass ranges such as "1% to 8%, " "1% to 5%, " "2% to 10%," etc. All numbers, amounts, ranges, etc. are intended to be modified by the term "about," whether or not expressly stated as such. Similarly, a given range of "about 1% to 10%" is intended to have the term "about" modify both 1% and 10%. Furthermore, when an amount of a component is given, it is intended to indicate the amount of active material, unless otherwise specified.

Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the present disclosure are approximations, unless otherwise indicated, the numerical values set forth in the specific examples are reported as precisely as possible. However, any numerical value inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements. The following examples serve to illustrate embodiments of the present disclosure, but are not intended to be limiting in nature.

All publications and patent applications cited herein are hereby incorporated by reference and for all purposes as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. In the event of a conflict between the present disclosure and any publication or patent application incorporated by reference herein, the present disclosure controls.

Claims (11)

a. 0.05 to 0.5% by weight of salicylic acid;
b. a weak organic acid or a salt thereof selected from benzoic acid, sorbic acid, levulinic acid, anisic acid, dehydroacetic acid, propionic acid, and combinations thereof;
c. A cosmetic composition comprising one or more divalent transition metal salts selected from the group consisting of zinc salts, copper gluconate, copper pyrrolidone carboxylate (copper PCA), and combinations thereof,
A cosmetic composition wherein all weight percentages are based on the total weight of the cosmetic composition. The cosmetic composition according to claim 1, wherein the weak organic acid or its salt is benzoic acid or its salt. The cosmetic composition according to claim 1 or 2, wherein the one or more divalent metal salts include a divalent metal salt of an organic acid selected from zinc lactate, zinc gluconate, zinc phenylsulfonate, zinc salicylate, zinc pyrrolidonecarboxylate (zinc PCA), zinc citrate, zinc ascorbate, copper gluconate, and combinations thereof. The cosmetic composition of claim 1, further comprising a suitable carrier system and additives selected from fatty compounds, fillers, polymers, surfactants, solvents, essential oils, botanical extracts, conditioners, emollients, skin-care ingredients, thickeners, antioxidants, other preservatives, active ingredients, fragrances, and combinations thereof. The cosmetic composition according to claim 4, wherein the one or more divalent transition metal salts are present in an amount of 0.01 to 0.5% by weight, based on the total weight of the cosmetic composition. The cosmetic composition according to claim 4 or 5, wherein the salicylic acid is present in an amount of 0.15 to 0.5% by mass, based on the total mass of the cosmetic composition. The cosmetic composition according to any one of claims 4 to 6, wherein the benzoic acid or salt thereof is present in an amount of 0.01 to 0.3% by mass, based on the total mass of the cosmetic composition. The cosmetic composition according to any one of claims 4 to 7, wherein the cosmetic composition is in the form of an oil-in-water emulsion. The cosmetic composition according to any one of claims 4 to 7 , wherein the cosmetic composition is in the form of a water-in-oil emulsion. The cosmetic composition according to claim 1 can be used as a hair composition, skin care composition, cleansing composition, or makeup composition. A) the following: a. 0.01 to 0.5% by weight of salicylic acid;
b. 0.01 to 0.3% by mass of benzoic acid or a salt thereof;
c. a preservative system comprising 0.01 to 0.5% by weight of one or more divalent transition metal salts selected from the group consisting of zinc salts, copper gluconate, copper pyrrolidone carboxylate (copper PCA), and combinations thereof;
B) 0.1 to 15% by weight of one or more fatty compounds;
C) 0.1 to 5% by weight of one or more fillers;
D) 0.1 to 10% by weight of one or more surfactants;
E) a suitable carrier,
A cosmetic composition, wherein all weight percentages are based on the total weight of said cosmetic composition.