JP7808992B2 - Aerosol for controlling creeping pests - Google Patents

Description

The present invention relates to a method for controlling crawling pests such as bedbugs using a metered-dose aerosol, and to an aerosol for controlling crawling pests such as bedbugs.

In recent years, the spread of bed bugs in some hotels and lodgings has become a social problem, and urgent countermeasures are needed. Targeting bed bugs that roam floors and walls and hide in crevices, insecticides that are applied to areas where bed bugs live or pass through have traditionally been (1) fumigants, (2) full-volume aerosol sprays, and (3) topical aerosol sprays, each with its own distinctive formulation.

(1) Fumigants and (2) total-discharge aerosols fall into the category of pharmaceuticals because they diffuse the chemicals into every corner of a room in one go, sealing the room for a specified period of time to increase the chemical concentration, and prohibit people from entering the room during that time. These formulations are characterized by their spatial treatment, in that the diffused chemicals are highly effective in eliminating bed bugs throughout the entire treatment space. However, these formulations require time and effort, such as preserving electrical appliances and tableware before treatment and cleaning up the sprayed sediment after treatment, and special attention must be paid to the safety of the chemicals, so they are not a formulation that can be easily and frequently adopted.

On the other hand, (3) topical aerosols, which are used for localized treatment, are often classified as quasi-drugs with mild effects on the human body, and their ease of use is highly regarded as a major advantage. For example, topical aerosols that combine pest control ingredients with specific saturated aliphatic hydrocarbons are known to be able to control bedbugs (see, for example, Patent Document 1).

In addition, as a method for exterminating crawling pests using smaller amounts of chemicals than (1) fumigants or (2) full-volume aerosols, a crawling pest extermination method is known in which an insecticide liquid containing an insecticidal component and a solvent is dispersed in small amounts over time using a piezoelectric sprayer (see, for example, Patent Document 2). The pest extermination method in Patent Document 2 is said to be able to exterminate crawling pests by continuously suspending small particles of insecticide liquid in a space such as an indoor space or a storage space.

JP 2013-170140 A JP 2009-143868 A

However, the paint-on aerosol of Patent Document 1 is not a spatial treatment like (1) fumigants or (2) total-amount spray aerosols, but rather a so-called local treatment that is effective against bed bugs only at the site of treatment. Therefore, the efficiency of contact between the chemical and bed bugs is inferior to (1) fumigants or (2) total-amount spray aerosols, and it does not necessarily provide an efficient extermination method.

The crawling pest extermination method in Patent Document 2 proposes exterminating cockroaches by continuously releasing minute amounts of chemicals into the air over an extended period of time, similar to liquid electric mosquito repellents. However, since the method targets cockroaches, which are resistant to chemicals, it is necessary to use powerful insecticidal ingredients, which inevitably raises safety concerns for humans. Furthermore, bedbugs have different ecology and habits from cockroaches, and the method in Patent Document 2 may not necessarily be able to effectively exterminate bedbugs.

Thus, there is a need for the development of a crawling pest control agent that is an easy-to-use quasi-drug that provides spatial treatment with excellent contact efficiency between the agent and bed bugs, but none has yet been put into practical use.

The present invention was made in consideration of the above-mentioned problems, and aims to provide a method for controlling crawling pests, particularly bedbugs, which have the habit of hiding in crevices, using a metered-dose aerosol, and an aerosol for controlling crawling pests.

The characteristic configuration of the crawling pest control method according to the present invention for solving the above problems is as follows:
A method for controlling crawling pests using a constant-dose aerosol, which is obtained by filling an aerosol concentrate containing a crawling pest control component and a solvent, and a propellant into an aerosol container equipped with a constant-dose injection valve,
The creeping pest control component is represented by the general formula (I):
[wherein X represents a hydrogen atom, a methyl group, or a methoxymethyl group, and R ¹ and R ² each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, a haloalkyl group having 1 to 3 carbon atoms, or a cyano group.], and a 2,3,5,6-tetrafluorobenzyl ester compound represented by the general formula (II):
[wherein Y represents a hydrogen atom or a cyano group, Z represents a hydrogen atom or a fluorine atom, and ^R3 and ^R4 each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, or a haloalkyl group having 1 to 3 carbon atoms],
The aerosol has a weight ratio of 2,3,5,6-tetrafluorobenzyl ester compound to 3-phenoxybenzyl ester compound in the aerosol concentrate that satisfies the following formula (1):
δ = b/(a+c)...(1)
δ as defined above satisfies 0.45 to 4.00,
When the filling volume of the aerosol concentrate is L and the filling volume of the propellant is G, the following formula (2) is obtained:
0.1≦L/(L+G)≦0.5...(2)
It is configured to satisfy
The aerosol is sprayed indoors into an open space.

This creeping pest control method uses a metered-dose aerosol spray to treat spaces, allowing for highly safe creeping pest control even in situations where people are present. Furthermore, by using a combination of a relatively highly volatile 2,3,5,6-tetrafluorobenzyl ester compound and a less volatile 3-phenoxybenzyl ester compound as the creeping pest control ingredient, the creeping pest control ingredient adheres to floors and walls, enhancing the control effect against creeping pests such as bedbugs that roam floors and walls. Furthermore, by combining the above-mentioned specific crawling pest control ingredients and solvent so that δ calculated from the above formula (1), which uses the content of each component of the aerosol concentrate as a parameter, falls within the above range, and by setting the value of the above formula (2), which uses the filling volume of the aerosol concentrate and propellant as parameters, within the above range, an unexpected synergistic effect can be achieved, which not only provides excellent control of crawling pests such as bed bugs that roam floors and walls, but also makes it possible to effectively control crawling pests such as bed bugs that hide in crevices.

In the creeping pest control method according to the present invention,
The solvent is preferably a lower alcohol having 2 to 3 carbon atoms or a higher fatty acid ester having 16 to 20 carbon atoms.

In this method for controlling creeping pests, the solvent is a lower alcohol with 2 to 3 carbon atoms or a higher fatty acid ester with 16 to 20 carbon atoms, which makes it easier for the spray particles to enter crevices, providing excellent control effects against creeping pests such as bedbugs that lurk in crevices.

In the creeping pest control method according to the present invention,
The creeping pest is preferably a bedbug.

This method for controlling creeping pests provides excellent control of creeping pests, particularly bedbugs.

The characteristic configuration of the aerosol spray for controlling crawling pests according to the present invention to solve the above problems is as follows:
General formula (I):
[wherein X represents a hydrogen atom, a methyl group, or a methoxymethyl group, and R ¹ and R ² each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, a haloalkyl group having 1 to 3 carbon atoms, or a cyano group.], and a 2,3,5,6-tetrafluorobenzyl ester compound represented by the general formula (II):
wherein Y represents a hydrogen atom or a cyano group, Z represents a hydrogen atom or a fluorine atom, and ^R3 and ^R4 each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, or a haloalkyl group having 1 to 3 carbon atoms.], and an aerosol concentrate containing a solvent, and a propellant are filled into an aerosol container equipped with a metered injection valve,
When the weight of the content of the 2,3,5,6-tetrafluorobenzyl ester compound in the aerosol concentrate is a, the weight of the content of the 3-phenoxybenzyl ester compound is b, and the weight of the content of the solvent in the aerosol concentrate is c, the following formula (1) can be obtained:
δ = b/(a+c)...(1)
δ as defined above satisfies 0.45 to 4.00,
When the filling volume of the aerosol concentrate is L and the filling volume of the propellant is G, the following formula (2) is obtained:
0.1≦L/(L+G)≦0.5...(2)
The object of the present invention is to provide a method for manufacturing a semiconductor device using the above-mentioned semiconductor device.

The crawling pest control aerosol of this configuration uses a combination of a 2,3,5,6-tetrafluorobenzyl ester compound, which has relatively high volatility, and a 3-phenoxybenzyl ester compound, which is less volatile, as the crawling pest control ingredient. This allows the crawling pest control ingredient to adhere to floors and walls, thereby enhancing the control effect against crawling pests such as bedbugs that roam floors and walls. Furthermore, by combining the above-mentioned specific crawling pest control ingredients and solvent so that δ calculated from the above formula (1), which uses the content of each component of the aerosol concentrate as a parameter, falls within the above range, and by setting the value of the above formula (2), which uses the filling volume of the aerosol concentrate and propellant as parameters, within the above range, an unexpected synergistic effect can be achieved, which not only provides excellent control of crawling pests such as bed bugs that roam floors and walls, but also makes it possible to effectively control crawling pests such as bed bugs that hide in crevices.

In the aerosol for controlling creeping pests according to the present invention,
The solvent is preferably a lower alcohol having 2 to 3 carbon atoms or a higher fatty acid ester having 16 to 20 carbon atoms.

The solvent of this aerosol for controlling crawling pests is a lower alcohol with 2 to 3 carbon atoms or a higher fatty acid ester with 16 to 20 carbon atoms, which allows the spray particles to easily penetrate gaps and provide excellent control effects against crawling pests such as bedbugs that lurk in gaps.

In the aerosol for controlling creeping pests according to the present invention,
It is preferable that the spray force at a spray distance of 5 cm is set to 3 to 50 gf.

With this type of aerosol for controlling crawling pests, setting the spray force at a spray distance of 5 cm to 3 to 50 gf ensures that a sufficient amount of crawling pest control ingredients adhere to floor and wall surfaces, and that the crawling pest control ingredients reach gaps in the treatment space, providing sufficient practical control effects against both crawling pests such as bed bugs that roam the floor and those that hide in gaps.

In the aerosol for controlling creeping pests according to the present invention,
The creeping pest is preferably a bedbug.

This aerosol for controlling crawling pests can provide excellent control of crawling pests, particularly bedbugs.

The method for controlling creeping pests and the aerosol for controlling creeping pests of the present invention are described below. However, the present invention is not intended to be limited to the configurations described below.

[Formulation of aerosol for controlling creeping pests]
The aerosol for controlling creeping pests of the present invention is a metered-dose type aerosol used to control creeping pests such as bed bugs by spatial treatment, and is configured by filling an aerosol concentrate containing a creeping pest control component and a solvent, and a propellant, into an aerosol container equipped with a metered-dose valve. Here, "spatial treatment" in the present invention refers to a treatment in which the creeping pest control component is widely dispersed throughout the treatment space, thereby controlling creeping pests such as bed bugs throughout the entire treatment space. Compared to local treatment in which the control component is applied locally and creeping pests are controlled only in the area where the control component is applied, spatial treatment has superior contact efficiency with creeping pests, and therefore can be expected to have a high control effect, but attention must be paid to the safety of people in the treatment space. In the crawling pest control method of the present invention, a metered-amount aerosol is sprayed indoors into the air, which allows for practically sufficient control of crawling pests such as bedbugs, while the amount of agent is less than that of fumigants or total-amount aerosols, resulting in a milder effect on the human body. In this specification, the term "control effect" refers to the control effect based on the knockdown effect and lethal effect, as well as the repellent effect. Even if the control effect is low, sufficient repellent effect can often achieve practical control.

<Concentrated aerosol>
The crawling pest control component, which is one of the main components of the aerosol concentrate, is represented by the general formula (I):
[wherein X represents a hydrogen atom, a methyl group, or a methoxymethyl group, and R ¹ and R ² each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, a haloalkyl group having 1 to 3 carbon atoms, or a cyano group.] and a 2,3,5,6-tetrafluorobenzyl ester compound having a common skeleton represented by general formula (II):
[wherein Y represents a hydrogen atom or a cyano group, Z represents a hydrogen atom or a fluorine atom, and ^R3 and ^R4 each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, or a haloalkyl group having 1 to 3 carbon atoms.] When a certain amount of the aerosol for controlling crawling pests of the present invention is sprayed into an indoor treatment space, the spray particles mainly settle on the floor surface as adhesive particles. By using a combination of compounds with different common skeletons, namely, a 2,3,5,6-tetrafluorobenzyl ester compound represented by general formula (I) and a 3-phenoxybenzyl ester compound represented by general formula (II), as crawling pest control components, the control effect against crawling pests such as bedbugs that crawl on floors and walls can be enhanced.

Examples of 2,3,5,6-tetrafluorobenzyl ester compounds represented by general formula (I) include metofluthrin, transfluthrin, profluthrin, momfluorothrin, dimefluthrin, tefluthrin, heptafluthrin, and mepafluthrin. Among these, metofluthrin, transfluthrin, and profluthrin are preferred, taking into consideration factors such as volatility (vapor pressure), stability, and basic insecticidal efficacy. The above 2,3,5,6-tetrafluorobenzyl ester compounds can be used alone or in combination. Furthermore, when optical isomers based on asymmetric carbons or geometric isomers based on double bonds exist in the acid moiety or alcohol moiety of a 2,3,5,6-tetrafluorobenzyl ester compound, these are encompassed within the present invention, as are any mixtures thereof.

Examples of 3-phenoxybenzyl ester compounds represented by general formula (II) include fenothrin, cyphenothrin, permethrin, cypermethrin, deltamethrin, cyhalothrin, and cyfluthrin. Among these, fenothrin, permethrin, and cyphenothrin are preferred. The above 3-phenoxybenzyl ester compounds can be used alone or in combination. Furthermore, when optical isomers based on asymmetric carbons or geometric isomers based on double bonds exist in the acid moiety or alcohol moiety of a 3-phenoxybenzyl ester compound, these isomers and any mixtures thereof are encompassed within the scope of the present invention.

The total content of the crawling pest control component in the aerosol concentrate, which is the 2,3,5,6-tetrafluorobenzyl ester compound and the 3-phenoxybenzyl ester compound, is preferably 30 to 75 w/v %. If the content of the crawling pest control component in the aerosol concentrate is within the above range, when the aerosol is sprayed, the spray particles are formed in an optimal state for controlling crawling pests such as bedbugs, and appropriate control effects can be obtained. If the content of the crawling pest control component in the aerosol concentrate is less than 30 w/v %, there is a risk that the amount of crawling pest control component released into the treatment space will be insufficient, resulting in insufficient control effects. If the content of crawling pest control ingredients in the aerosol concentrate exceeds 75 w/v%, there is a risk that when the aerosol is sprayed, the spray particles will not be formed in an optimal state for controlling crawling pests such as bedbugs.

Solvents, which are one of the main components of aerosol concentrates, include lower alcohols with 2 to 3 carbon atoms, hydrocarbon solvents (such as normal paraffin solvents and isoparaffin solvents), higher fatty acid esters with 16 to 20 carbon atoms, glycol ether solvents with 3 to 10 carbon atoms, and ketone solvents. Lower alcohols with 2 to 3 carbon atoms or higher fatty acid esters with 16 to 20 carbon atoms are preferred. Using these solvents allows spray particles to easily penetrate crevices after spraying, providing excellent control of crawling pests such as bedbugs that lurk in crevices. Examples of lower alcohols with 2 to 3 carbon atoms include ethanol, 1-propanol, and 2-propanol. Examples of higher fatty acid esters with 16 to 20 carbon atoms include isopropyl myristate, butyl myristate, and hexyl laurate. Of these, ethanol or isopropyl myristate is preferred from the viewpoint of ease of penetration into gaps, and ethanol is more preferred from the viewpoint of ease of penetration into gaps due to evaporation after spraying and reduced particle size.

The aerosol concentrate has a weight ratio of 2,3,5,6-tetrafluorobenzyl ester compound to 3-phenoxybenzyl ester compound, b to 3-phenoxybenzyl ester compound, and c to 2,3,5,6-tetrafluorobenzyl ester compound, expressed as a, b, and c, respectively, of the following formula (1):
δ = b/(a+c)...(1)
The δ calculated from the above formula (1) is a parameter indicating the weight ratio of the hardly volatile component (3-phenoxybenzyl ester compound) to the highly volatile components (2,3,5,6-tetrafluorobenzyl ester compound and solvent) in the aerosol concentrate, and by combining the above-mentioned specific crawling pest control components and solvent so that the δ value is 0.45 to 4.00, an unexpected synergistic effect can be achieved, making it possible to effectively control crawling pests such as bed bugs that roam floors and walls, as well as crawling pests such as bed bugs that hide in crevices.

In addition to the above ingredients, the aerosol concentrate may also contain antifungal agents, antibacterial agents, disinfectants, antiviral agents, fragrances, deodorizers, stabilizers, antistatic agents, antifoaming agents, and excipients that target mold, fungi, viruses, etc. Examples of antifungal agents, antibacterial agents, disinfectants, and antiviral agents include hinokitiol, 2-mercaptobenzothiazole, 2-(4-thiazolyl)benzimidazole, 5-chloro-2-methyl-4-isothiazolin-3-one, triforine, 3-methyl-4-isopropylphenol, and ortho-phenylphenol. Further, examples of fragrances include orange oil, lemon oil, lavender oil, peppermint oil, eucalyptus oil, citronella oil, lime oil, yuzu oil, jasmine oil, cypress oil, green tea essential oil, limonene, α-pinene, linalool, geraniol, phenylethyl alcohol, amyl cinnamic aldehyde, cumin aldehyde, and benzyl acetate, as well as fragrance ingredients containing leaf alcohol and leaf aldehyde, known as "green scents."

The aerosol for controlling crawling pests of the present invention can also be formulated as a water-based formulation. In this case, the amount of water contained in the aerosol concentrate is preferably approximately 5 to 50 v/v%, and a small amount of a nonionic surfactant may be added as a solubilizing aid, as long as it does not affect the spray pattern of the spray particles. Examples of nonionic surfactants include ethers such as polyoxyethylene alkyl ethers, polyoxyethylene alkylphenyl ethers, polyoxyethylene polyoxypropylene alkyl ethers, and polyoxyethylene alkylamino ethers; fatty acid esters such as polyethylene glycol fatty acid esters, polyoxyethylene sorbitan fatty acid esters, and polyoxyethylene glycerin fatty acid esters; polyoxyethylene styrenated phenol; and polyalkalolamides of fatty acids. Of these, ethers are preferred.

<Propellant>
Examples of propellants used in the aerosol spray for controlling creeping pests of the present invention include liquefied gases such as liquefied petroleum gas (LPG), dimethyl ether (DME), and hydrofluoroolefins, nitrogen gas, carbon dioxide gas, nitrous oxide, and compressed air, among which liquefied gases are preferred. The above propellants can be used alone or in a mixture, but those containing LPG as the main component are easy to use.

The aerosol for controlling creeping pests of the present invention has a filling volume of the aerosol concentrate filled in the aerosol container defined as L and a filling volume of the propellant defined as G, and the filling volume of the aerosol for controlling creeping pests of the present invention is expressed by the following formula (2):
0.1≦L/(L+G)≦0.5...(2)
[0033] The formula (2) is configured to satisfy the following. By satisfying the formula (2), a sufficient amount of the crawling pest control component can be uniformly diffused throughout the floor, wall, and gaps within the treatment space. If [L/(L+G)] is less than 0.1, i.e., if a large amount of propellant is enclosed in the aerosol container, the spray particles formed from the sprayed aerosol concentrate may be unnecessarily fine, and there is a risk that the amount of the crawling pest control component adhering to the floor and wall may be insufficient. If [L/(L+G)] is greater than 0.5, i.e., if a small amount of propellant is enclosed in the aerosol container, the spray particles may become large, and there is a risk that the crawling pest control component will not reach the gaps sufficiently.

[Aerosol nozzle for controlling creeping pests]
The shape (cross-sectional shape) of the nozzle of the aerosol spray for controlling crawling pests of the present invention is not particularly limited, but may include circles, polygons such as squares, and ellipses, with circles being preferred. Here, the nozzle diameter refers to the major axis of the ellipse when the nozzle shape is elliptical, and the diameter of the circumscribed circle of the polygon when the nozzle shape is polygonal. The opening area of the nozzle is preferably 0.05 to 8.0 ^mm2 , more preferably 0.1 to 4.0 ^mm2 , and even more preferably 0.2 to 3.0 ^mm2 . For example, when there is one nozzle and the nozzle shape is circular, the size of the nozzle (nozzle diameter) is preferably 0.2 mm or more, more preferably 0.3 mm or more, and even more preferably 0.5 mm or more. The nozzle diameter is preferably 3.0 mm or less, more preferably 2.0 mm or less, and even more preferably 1.8 mm or less. If the nozzle diameter is 0.2 to 3.0 mm, the size of the spray particles will be appropriate, allowing a sufficient amount of crawling pest control component to reach gaps, making it possible to effectively control crawling pests such as bedbugs that lurk in gaps.

The number of nozzles in the aerosol for controlling creeping pests of the present invention may be one or two or more, but from the perspective of simple and low-cost production, it is preferable that the number of nozzles be one.

The nozzle of the aerosol for controlling crawling pests of the present invention typically has an elevation angle of 0 to 60° relative to the horizontal plane, preferably 10 to 60°, and more preferably 15 to 50°. If the elevation angle of the nozzle relative to the horizontal plane is within the above range, poor spraying is unlikely to occur and the aerosol concentrate can be sprayed stably. The elevation angle of the nozzle relative to the horizontal plane of a nozzle or actuator with two nozzles is the elevation angle relative to the horizontal plane of the perpendicular bisector of the line segment connecting the centers of each nozzle. For nozzles or actuators with three or more nozzles, the elevation angle of the nozzle relative to the horizontal plane is defined as follows: For nozzles or actuators with a nozzle located in the center of the nozzle section, the elevation angle is the elevation angle relative to the horizontal plane of an orthogonal line passing through the center of the central nozzle. For nozzles or actuators with no nozzle located in the center of the nozzle section, the elevation angle is the elevation angle relative to the horizontal plane of an orthogonal line passing through the center of the circumscribing circle of a polygon connecting the centers of each nozzle.

The spray force of the crawling pest control aerosol of the present invention is preferably set to 3 to 50 gf at a point 5 cm away from the nozzle, and more preferably 10 to 30 gf. A spray force in the range of 3 to 50 gf ensures that a sufficient amount of crawling pest control ingredient adheres to floor and wall surfaces, and that the crawling pest control ingredient reaches gaps in the treatment space, providing a practically sufficient control effect against both crawling pests such as bed bugs that roam the floor and those that hide in gaps. In this embodiment, the spray force of the pest control aerosol was measured using a digital force gauge (FGC-0.5, manufactured by Nidec-Shimpo Corporation).

The aerosol for controlling crawling pests of the present invention preferably has a spray volume per injection from the metered injection valve of 0.1 to 5.0 mL, more preferably 0.2 to 3.0 mL, and even more preferably 0.2 to 1.0 mL. If the spray volume per injection is 0.1 to 5.0 mL, for example, in a treatment space with a volume of 18.8 to 33.3 m ³ (area 7.5 to 13.3 m ² , height 2.2 to 3.0 m), equivalent to a room of 4.5 to 8 tatami mats, by spraying the aerosol for controlling crawling pests once or several times, the amount of crawling pest control component released will be appropriate, and a practically sufficient control effect against crawling pests will be obtained in the treatment space, and excellent control effect will be obtained, particularly against bed bugs. Furthermore, if the spray volume per injection is 0.1 to 5.0 mL, a treatment frequency of once every 1 to 7 days will be sufficient.

The shapes of the nozzle, container, etc., of the aerosol sprayer for controlling crawling pests of the present invention can be selected appropriately depending on the application, intended use, etc. For example, it can be a tabletop type with a button that is pressed from above to spray and a nozzle that faces diagonally upward, or it can be designed as a small, portable container. Furthermore, the actuator for activating the aerosol sprayer for controlling crawling pests can have a nozzle or not. If it has a nozzle, it can have either a protruding nozzle or a non-protruding nozzle, but a protruding nozzle is preferred. For an actuator with a nozzle, the length of the nozzle is not particularly limited, but is preferably 2.0 to 80 mm, more preferably 3.0 to 70 mm, and particularly preferably 4.0 to 60 mm. The operating button on the actuator can be a push-down type or a trigger type.

[Crawling pest control method]
The crawling pest control method of the present invention involves spraying a metered-dose aerosol containing a specific crawling pest control component and a solvent, such as the crawling pest control aerosol of the present invention, into a treatment space. When using fumigants or total-dose aerosols, people are not allowed to enter the treatment space during chemical treatment, and the treatment space must be closed off for 2-3 hours. In addition, electrical appliances and tableware must be cured before treatment, and sprayed sediment must be cleaned up after treatment. In contrast, the crawling pest control method of the present invention uses a metered-dose aerosol, which allows for the amount of crawling pest control component sprayed into the treatment space to be kept to a minimum. Therefore, the crawling pest control method of the present invention eliminates the pre-treatment preparation procedures and post-treatment cleanup required for fumigants and total-dose aerosols. Furthermore, since the creeping pest control method of the present invention uses a fixed-amount spray type aerosol to perform spatial treatment, treatment for crawling pest control can be safely carried out without leaving the indoor space that is the treatment space. In this way, the creeping pest control method of the present invention employs a spatial treatment method that is more effective than local treatment methods, while providing convenience that cannot be expected from spatial treatment using conventional fumigants or total-amount spray type aerosols.

In the method for controlling creeping pests of the present invention, when the aerosol for controlling creeping pests is sprayed indoors, the amount of the creeping pest control component released into the air is preferably 0.1 to 50 mg/m ³ , and more preferably 0.5 to 50 mg/m ^3. When the amount of the creeping pest control component released into the air is within the above range, it is possible to obtain an excellent control effect against creeping pests, particularly bed bugs, while maintaining high safety even in situations where people are present. When the creeping pest control method of the present invention is carried out in an indoor treatment space with a volume of 18.8 to 33.3 ^{m 3} (area 7.5 to 13.3 m ² , height 2.2 to 3.0 m) equivalent to a room of 4.5 to 8 tatami mats (approximately 12.5 to 18.5 m 3), using a creeping pest control aerosol equipped with a metered injection valve with a single injection volume of 1.0 to 5.0 mL, a single injection typically results in the release of 0.1 to 50 mg/m ³ of creeping pest control component into the air. In indoor treatment spaces with larger volumes, multiple injections can be performed so that the release amount of 0.1 to 50 mg/m ³ of creeping pest control component into the air is adjusted to the volume of the treatment space, thereby achieving a similar control effect regardless of the size of the treatment space. Even when using an aerosol sprayer equipped with a metered dose valve with a single spray volume of less than 1.0 mL, for example, 0.1 to 0.9 ^mL , by appropriately adjusting the number of sprays so that the amount of crawling pest control component released into the air is 0.1 to 50 mg/m3, it is possible to obtain excellent control effects against crawling pests, particularly bed bugs.

The crawling pest control method of the present invention is preferably carried out once every 1 to 7 days. As described above, the crawling pest control method of the present invention uses a crawling pest control component containing a 2,3,5,6-tetrafluorobenzyl ester compound and a 3-phenoxybenzyl ester compound in combination with a solvent (preferably a lower alcohol having 2 to 3 carbon atoms or a higher fatty acid ester having 16 to 20 carbon atoms) in combination, thereby achieving a synergistic effect that further improves the control effect against crawling pests, particularly bed bugs. Therefore, even if the method is carried out once every 1 to 7 days, a practically sufficient control effect against crawling pests can be expected, and excellent control effect against bed bugs in particular can be achieved. In this way, the crawling pest control method of the present invention can reduce the frequency of application of aerosols for controlling crawling pests.

In the creeping pest control method of the present invention, the creeping pest control aerosol is preferably sprayed so that the spray direction angle is 0 to 60 degrees relative to the horizontal plane, and more preferably 30 to 60 degrees. If the aerosol spray direction angle is within the above range, excellent diffusion uniformity will be achieved.

The type of creeping pest that the creeping pest control method of the present invention is effective against is not particularly limited. Examples of creeping pests include spiders, cockroaches, centipedes, ants, house centipedes, millipedes, pill bugs, woodlice, termites, caterpillars, mites, lice, ticks, and bedbugs. Among these, the method is effective in controlling spiders, cockroaches, and bedbugs, and is particularly effective in controlling bedbugs such as bedbugs (Cimex lectularius) and Taiwanese bedbugs (Nettite bedbugs).

To verify the effectiveness of the present invention, aerosols for controlling crawling pests (Examples 1 to 17) equipped with the characteristic configuration of the present invention were prepared, and their effectiveness in exterminating bed bugs that roam the floor and those hiding in crevices was examined. For comparison, aerosols for controlling crawling pests (Comparative Examples 1 to 8) that do not have the characteristic configuration of the present invention were prepared, and a similar examination was conducted.

Example 1
An aerosol concentrate was prepared by dissolving 0.168 g (0.56 w/v%) of metofluthrin as compound A, a 2,3,5,6-tetrafluorobenzyl ester compound, and 13.20 g (44 w/v%) of fenothrin as compound B, a 3-phenoxybenzyl ester compound, in 13.76 g of ethanol as a solvent. This aerosol concentrate had a δ value of 0.948, calculated using the aforementioned formula (1). 30 mL of this aerosol concentrate and 70 mL of liquefied petroleum gas were pressurized and filled into an aerosol container equipped with a metered injection valve (0.4 mL per injection), to obtain the aerosol for controlling crawling pests used in Example 1. This aerosol for controlling crawling pests had a volume ratio [L/(L+G)] of 0.3, calculated from the fill volume L of the aerosol concentrate and the fill volume G of the propellant, and had a spray force of 14 gf at a spray distance of 5 cm.

Example 2
An aerosol concentrate was prepared by dissolving 0.168 g (0.56 w/v%) of metofluthrin as compound A, a 2,3,5,6-tetrafluorobenzyl ester compound, and 13.20 g (44 w/v%) of fenothrin as compound B, a 3-phenoxybenzyl ester compound, in 13.76 g of ethanol as a solvent. This aerosol concentrate had a δ value of 0.948, calculated using the aforementioned formula (1). 30 mL of this aerosol concentrate and 70 mL of liquefied petroleum gas were pressurized and filled into an aerosol container equipped with a metered injection valve (0.2 mL per injection), to obtain the aerosol for controlling crawling pests used in Example 2. This aerosol for controlling crawling pests had a volume ratio [L/(L+G)] of 0.3, calculated from the fill volume L of the aerosol concentrate and the fill volume G of the propellant, and had a spray force of 5 gf at a spray distance of 5 cm.

Example 3
An aerosol concentrate was prepared by dissolving 0.168 g (0.56 w/v%) of metofluthrin as compound A, a 2,3,5,6-tetrafluorobenzyl ester compound, and 13.20 g (44 w/v%) of fenothrin as compound B, a 3-phenoxybenzyl ester compound, in 13.76 g of ethanol as a solvent. This aerosol concentrate had a δ value of 0.948, calculated using the aforementioned formula (1). 30 mL of this aerosol concentrate and 70 mL of liquefied petroleum gas were pressurized and filled into an aerosol container equipped with a metered injection valve (spray volume per injection: 1.0 mL), to obtain the aerosol for controlling crawling pests used in Example 3. This aerosol for controlling crawling pests had a volume ratio [L/(L+G)] of 0.3, calculated from the fill volume L of the aerosol concentrate and the fill volume G of the propellant, and had a spray force of 27 gf at a spray distance of 5 cm.

[Examples 4 to 17, Comparative Examples 1 to 8]
Various aerosols for controlling crawling pests were prepared according to the procedure of Example 1 with the formulations shown in Tables 1 and 2. Each aerosol for controlling crawling pests was prepared so that the spray force at a spray distance of 5 cm was 14 gf.

Tests were conducted on Examples 1 to 17 and Comparative Examples 1 to 8 to confirm (1) their effectiveness in exterminating bed bugs that roam the floor, and (2) their effectiveness in exterminating bed bugs that hide in crevices. The test results are shown in Table 3.

(1) Efficacy of exterminating bed bugs roaming the floor A total of four 20 x 20 cm glass plates were placed in the ^four corners of a closed room with a volume of 25 m (equivalent to a room of 6 tatami mats, area ¹⁰ m). A plastic ring with a diameter of approximately 10 cm coated with Vaseline to prevent escape was placed on each glass plate, and a predetermined test insect (five bed bugs) was released into each ring and allowed to roam freely. In Examples 1, 4 to 17, and Comparative Examples 1 to 8, 0.4 mL of the test aerosol was sprayed four times in the center of the room, slightly diagonally upward toward the four corners. In Example 2, 0.2 mL of the test aerosol was sprayed six times in the center of the room, slightly diagonally upward toward the four corners. In Example 3, 1.0 mL of the test aerosol was sprayed one time in the center of the room, slightly diagonally upward. After the spraying, the insects were left exposed to the agent for 24 hours, and then the glass plate together with the ring containing the test insects was moved to another room, where they were fed, and after another 24 hours the mortality rate of the test insects was determined.

(2) Effect of exterminating bed bugs hiding in crevices. Tub smeared with Vaseline to prevent escape (35 cm wide, 28 cm deep, 6 cm high) were placed in the ^four corners of a closed room with a volume of 25 m3 (equivalent to a 6-tatami room, area 10 ^m2 ). Five bed bugs were released into each tub, and a wooden shelter (20 cm wide, 10 cm deep, 1 cm high, open only at the front) was placed to allow the bed bugs to hide. In Examples 1, 4 to 17, and Comparative Examples 1 to 8, 0.4 mL of the test aerosol was sprayed four times in the center of the room, slightly diagonally upward toward the four corners. In Example 2, 0.2 mL of the test aerosol was sprayed six times in the center of the room, slightly diagonally upward toward the four corners. In Example 3, 1.0 mL of the test aerosol was sprayed one time in the center of the room, slightly diagonally upward. After spraying, the bats were left to stand for 30 minutes to be exposed to the agent, and then the wooden shelters in which the test insects were hiding were moved to another room, where they were given food, and the mortality rate of the test insects was determined after a further 5 days.

The test results showed that in all of Examples 1 to 17, the mortality rate for bed bugs crawling on floors was 85% or higher, and the mortality rate for bed bugs hiding in crevices was 80% or higher. This confirms that by implementing the crawling pest control method of the present invention, it is possible to achieve high levels of effectiveness in controlling both bed bugs crawling on floors and those hiding in crevices. The crawling pest control aerosol used in Examples 1 and 4 to 17 was effective for approximately 60 treatments, assuming 1.6 mL (0.4 mL x 4) was used per treatment. The crawling pest control aerosol used in Example 2 was effective for approximately 80 treatments, assuming 1.2 mL (0.2 mL x 6) was used per treatment. The aerosol for controlling crawling pests used in Example 3 was effective for approximately 100 treatments, assuming 1.0 mL was used per treatment.

In contrast, in Comparative Examples 1 and 2, where the δ value calculated using the above formula (1) was outside the range of 0.45 to 4.00, sufficient control effects were not achieved against either bed bugs that roam the floor or those that hide in crevices. Therefore, it is believed that when the δ value is outside the range of 0.45 to 4.00, the synergistic effect of using the 2,3,5,6-tetrafluorobenzyl ester compound, the 3-phenoxybenzyl ester compound, and the solvent, which is a lower alcohol having 2 to 3 carbon atoms or a higher fatty acid ester having 16 to 20 carbon atoms, in combination is not fully exerted.

In Comparative Example 3, which used empenthrin, a compound other than a 2,3,5,6-tetrafluorobenzyl ester compound, as compound A, the control effect against bed bugs hiding in crevices was insufficient, particularly against bed bugs hiding in crevices. In Comparative Example 4, which used imiprothrin, a compound other than a 3-phenoxybenzyl ester compound, as compound B, almost no control effect was observed against either bed bugs that roam the floor or bed bugs that hide in crevices. Furthermore, in Comparative Example 5, which contained only compound B, a 3-phenoxybenzyl ester compound, as the crawling pest control ingredient, the control effect against bed bugs hiding in crevices was insufficient, particularly against bed bugs that hide in crevices. In Comparative Example 6, which contained only compound A, a 2,3,5,6-tetrafluorobenzyl ester compound, as the crawling pest control ingredient, almost no control effect was observed against either bed bugs that roam the floor or bed bugs that hide in crevices. From this, it is believed that in order to achieve sufficient control effects against both bed bugs that roam the floor and those that hide in crevices, it is effective to use multiple types of crawling pest control ingredients in combination, but simply using multiple types of crawling pest control ingredients in combination is not sufficient, and it is necessary to use a combination of the specific 2,3,5,6-tetrafluorobenzyl ester compound and 3-phenoxybenzyl ester compound specified in the present invention.

Comparative Example 7, in which the volume ratio [L/(L+G)] calculated from the fill volume L of the aerosol concentrate and the fill volume G of the propellant was 0.6 and the fill volume of the aerosol concentrate was excessively high, provided high control effectiveness against bed bugs roaming the floor, but was insufficient in controlling bed bugs hiding in crevices. This is thought to be because the large fill volume of the aerosol concentrate resulted in large spray particles that settled to the floor surface too quickly, preventing the spray particles from reaching crevices insufficiently and reducing their effectiveness in controlling bed bugs hiding in crevices. On the other hand, Comparative Example 8, in which the volume ratio [L/(L+G)] was 0.05 and the fill volume of the propellant was excessively high, provided high control effectiveness against bed bugs hiding in crevices, but was insufficient in controlling bed bugs roaming the floor. This is thought to be because the propellant's filling volume is so large that the spray particles become excessively small, making it easier for them to reach gaps, but the spray particles that do not reach the gaps remain in the air for a long time without settling on the floor, resulting in a shortage of crawling pest control ingredients adhering to the floor.

[Reference example 1]
To confirm the effect of using a solvent other than the solvents used in the examples (ethanol, 2-propanol, isopropyl myristate) in the aerosol for controlling crawling pests of the present invention, an aerosol for controlling crawling pests (Reference Example 1) was prepared by using Isopar M, an isoparaffinic solvent, instead of 2-propanol as the solvent in the formulation of Example 7. The aerosol for controlling crawling pests of Reference Example 1 had a δ value calculated by the above-mentioned formula (1) of 2.28, a volume ratio [L/(L+G)] calculated from the fill volume L of the aerosol concentrate and the fill volume G of the propellant of 0.3, and a spray force of 14 gf at a spray distance of 5 cm.

When the aerosol for controlling crawling pests in Reference Example 1 was subjected to a control efficacy confirmation test similar to that in the above examples, the mortality rate for bed bugs crawling on the floor (after one day) was 80%, but the mortality rate for bed bugs hiding in crevices (after five days) was only 15%, indicating that the control effect for bed bugs hiding in crevices was lower than that for bed bugs crawling on the floor. This is thought to be because the spray particles did not reach the crevices sufficiently after spraying, and the control effect (synergistic effect) of the specific 2,3,5,6-tetrafluorobenzyl ester compound specified in the present invention and the 3-phenoxybenzyl ester compound against bed bugs hiding in crevices was not as strong as in the examples.

(3) Spider extermination effect 1
A total of four 20 x 20 cm glass plates (for therid spiders) were placed in the ^four corners of a closed room with a volume of 25 m (equivalent to a 6-tatami room, area ¹⁰ m). A plastic ring with a diameter of approximately 20 cm was placed on each glass plate, and a designated test insect (one therid spider) was released into each ring and allowed to wander freely. The crawling pest control aerosol of Example 9 was sprayed four times in the center of the room (1.5 m above the floor), 0.4 mL of the test aerosol sprayed at a slightly upward angle. After 30 minutes of spraying, the test insects were exposed to the agent. The glass plates, along with the rings containing the test insects, were then moved to another room and fed. After a further 24 hours, the mortality rate of the test insects was determined, which was 100%.

(4) Spider extermination effect 2
A total of four 20 x 20 cm glass plates (for therid spiders) were placed in the ^four corners of a closed room with a volume of 25 m (equivalent to a 6-tatami room, area ¹⁰ m). A plastic ring with a diameter of approximately 20 cm was placed on each glass plate, and a designated test insect (one therid spider) was released into each ring and allowed to wander freely. The crawling pest control aerosol of Example 12 was sprayed four times in the center of the room (1.5 m above the floor), 0.4 mL of the test aerosol sprayed at a slightly upward angle. After 30 minutes of spraying, the test insects were exposed to the agent. The glass plates, along with the rings containing the test insects, were then moved to another room and fed. After a further 24 hours, the mortality rate of the test insects was determined, which was 100%.

(5) Cockroach extermination effect 1
A total of four 20 x 20 cm glass plates (for American cockroaches) were placed in the ^four corners of a closed room with a volume of 25 m (equivalent to a room with a 6-tatami mat area, ¹⁰ m). A plastic ring with a diameter of approximately 20 cm was placed on each glass plate, and a designated test insect (American cockroach: five larvae) was released into each ring and allowed to roam freely. The crawling pest control aerosol of Example 9 was sprayed four times in the center of the room (1.5 m above the floor), 0.4 mL of the test aerosol spray being directed slightly upward. After 30 minutes of spraying, the test insects were exposed to the agent. The glass plates, along with the rings containing the test insects, were then moved to another room and fed. After a further 24 hours, the mortality rate of the test insects was determined; the mortality rate was 100%.

(6) Cockroach extermination effect 2
A total of four 20 x 20 cm glass plates (for American cockroaches) were placed in the ^four corners of a closed room with a volume of 25 m (equivalent to a 6-tatami room, area ¹⁰ m). A plastic ring with a diameter of approximately 20 cm was placed on each glass plate, and a designated test insect (American cockroach: five larvae) was released into each ring and allowed to roam freely. The crawling pest control aerosol of Example 12 was sprayed four times in 0.4 mL increments, spraying in a slightly upward direction in the center of the room (1.5 m above the floor). After 30 minutes of spraying, the test insects were allowed to be exposed to the agent. The glass plates, along with the rings containing the test insects, were then moved to another room, where they were fed. After a further 24 hours, the mortality rate of the test insects was determined; it was 95%.

The crawling pest control method and crawling pest control aerosol of the present invention can be used to control crawling pests, particularly bedbugs, in ordinary houses, accommodation facilities, etc.

Claims (2)

General formula (I):
[wherein X represents a hydrogen atom, a methyl group, or a methoxymethyl group, and R ¹ and R ² each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, a haloalkyl group having 1 to 3 carbon atoms, or a cyano group.], and a 2,3,5,6-tetrafluorobenzyl ester compound represented by the general formula (II):
wherein Y represents a hydrogen atom or a cyano group, Z represents a hydrogen atom or a fluorine atom, and ^R3 and ^R4 each represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, or a haloalkyl group having 1 to 3 carbon atoms.], and an aerosol concentrate containing a solvent, and a propellant are filled into an aerosol container equipped with a metered injection valve,
When the weight of the content of the 2,3,5,6-tetrafluorobenzyl ester compound in the aerosol concentrate is a, the weight of the content of the 3-phenoxybenzyl ester compound is b, and the weight of the content of the solvent in the aerosol concentrate is c, the following formula (1) can be obtained:
δ = b/(a+c)...(1)
δ defined as follows is between 0.522 and 2.52;
When the filling volume of the aerosol concentrate is L and the filling volume of the propellant is G, the following formula (2) is obtained:
0.1≦L/(L+G)≦0.5...(2)
It is configured to satisfy
The spray force at a spray distance of 5 cm is set to 10 to 50 gf.
the 2,3,5,6-tetrafluorobenzyl ester compound is at least one selected from the group consisting of metofluthrin, transfluthrin, and profluthrin,
the 3-phenoxybenzyl ester compound is at least one selected from the group consisting of fenothrin, permethrin, and cyphenothrin;
the solvent is ethanol,
The amount of the metered injection valve per injection is 0.2 to 1.0 mL;
The aerosol for controlling creeping pests, wherein the creeping pests are bedbugs. The aerosol for controlling crawling pests according to claim 1 is sprayed indoors into a space to control bedbugs hiding in gaps within the space.