JPS5810107B2 - Infusion set with filter - Google Patents

Description

[Detailed description of the invention] The present invention relates to an infusion set with a filter.

In conventionally well-known infusion sets, a filter is installed in the liquid introduction process for the purpose of cleaning the medicinal solution.

For example, they have been appropriately incorporated inside drip tubes, octopus tubes, or the base of intravenous needles to achieve their purpose to some extent.

Of course, for the above purpose, the end of the conduit,
In other words, it is natural that it is better to install the filter closer to the patient.

Therefore, some types of intravenous needles have a deep trapping type (
In the past, a so-called defusable (defusal) filter was used, but there were problems such as variations in filtration accuracy, the risk of the filter material falling off, and insufficient flow rate for highly viscous chemical solutions. It was hard to say that it was sufficient.

Surface-trapping type (so-called model) filters were also used in contrast to differential filters.

This demolded filter provides a satisfactory flow rate, and there is no need to worry about the filter material falling off.

However, in general, removable filters for infusions have approximately 0.
．． Hydrophilic synthetic resins with a pore size of about 1 to 10 μm are used, but these have a film thickness of 100 μm or more for strength in actual use, and bubble point (hydrophilic) When a porous membrane is wet with liquid and the pressure is increased to allow gas to pass through the membrane, this is the pressure at which gas first passes through the membrane.

) was about 0.3 to 4.0 kg/cm2, so even when it was installed near the venous needle, it did not pass through at all.

This is because the total length of a general infusion set (the length from the bottle needle to the intravenous needle) is approximately 60 to 150 cm, so it is necessary to insert the bottle needle of the infusion set into the bag (or bottle) containing the drug solution. Even when the intravenous needle is lowered all at once, the pressure applied to the filter is approximately 0.05 to 0.2 k.
This is because the pressure is only about g/cm2, which is smaller than the bubble point of the filter.

This means that the inside of the conduit is filled with drug solution at the beginning of infusion (
This made it difficult to remove air bubbles during frying.

The present invention has been made focusing on the above problems, and includes:
The purpose is to provide an infusion set with a filter that allows easy removal of air bubbles during frying and is simple to manufacture.

That is, in the infusion set of the present invention, a membrane material made of synthetic resin is coated on a woven or non-woven fabric to have a pore size of 0.1 to 10.
This is an infusion set with a filter, which is characterized by having a filter with μ and a bubble point of 0.2 kg/Cm2 or less installed near the venous needle.

Generally, the bubble point of a membrane is determined by the membrane manufacturing method, membrane material, membrane thickness, pore size, etc., but the filter used in the present invention can physically reach the bubble point without changing the membrane pore size or material. is 0.2 kg/cm' or less.

Methods for manufacturing model filters include the phase separation method, extraction method, and neutron irradiation method, but model filters made from cellulose ester are all manufactured using the phase separation method.

First, cellulose ester is dissolved in a good solvent (acetone, methyl acetate, methyl chloride, etc.), and an appropriate amount of a non-solvent (alcohol, water, etc.) is added thereto (hereinafter referred to as a solution).

) is used as a support to receive the liquid cast, and has nothing to do with the final filter.

) and gradually dry it to phase separate the solution (
It is thought that the phase-separated liquid forms a continuous phase containing a good solvent and cellulose ester, and a dispersed spherical phase mainly consisting of a non-solvent.

let

As the system becomes kelized, dispersed spheres become the element of micropores in the membrane, and the diameter of these spheres is determined by the interfacial tension between them and the continuous phase.

The manufacturing method for a general model filter has been described above, but the filter used in the present invention is cast on a woven or non-woven fabric instead of a support when the solution is cast in the above general filter manufacturing process. A so-called desolvent is produced in the form of a coating on the woven or nonwoven fabric, either by spreading or by immersing the woven or nonwoven fabric in the desolvent.

In this case, the membrane material is not particularly limited as long as it is a synthetic resin, but the final filter must exhibit hydrophilicity.

This applies not only to the present invention but also to filters for removing foreign substances used in infusion sets.

If the membrane material of the finished filter exhibits hydrophilic properties, there is no need to perform any hydrophilic treatment, but if the membrane material does not exhibit hydrophilic properties, hydrophilic treatment is necessary.

Membrane materials used in the present invention include, for example, cellulose acetate, vinyl chloride, and nylon; however, since the finished filters of these materials do not exhibit hydrophilic properties, hydrophilic treatment such as chrycerin is applied during desolution. However, these hydrophilic treatment methods are well known in the art. There are various techniques.

The woven fabric or nonwoven fabric is not particularly limited as long as it does not dissolve in the solution removed and has an average pore diameter larger than the pore diameter of the final filter.

It is particularly preferable to use a polyester nonwoven fabric because polyester has no elasticity, so the membrane will not be damaged, and the solution can be easily applied.

Table 1 shows a reference example of a filter that uses cellulose acetate as the membrane material and does not use non-woven fabric, and a filter made by selecting polyester resin or polyethylene resin as the non-woven fabric and applying a desolution solution containing glycerin. As Examples 1 and 2, bubble points were compared.

As can be seen from Table 1, the actual thickness of the membrane material in Examples 1 and 2 is considerably smaller than that in the reference example, and this is considered to have led to a decrease in the bubble point.

In other words, since the non-woven fabric acts as a reinforcing material for the membrane material, the thickness of the membrane material itself can be reduced, and for products that do not use non-woven fabric, the thickness of the membrane material must be increased to withstand actual use. As a result, bubble points are expected to increase.

Next, an example in which the filter of the present invention is actually incorporated into an infusion set will be explained with reference to the drawings.

In the drawings, the same reference numerals are used to indicate the same parts.

The one shown in Figure 1 is a bullet-shaped filter obtained by overlapping two filter sheets, leaving one end and sealing the other end with heat fusion to obtain sufficient filtration area and flow rate. And the seal part is 2.

Figure 2 shows a modified example of this, in which a single long filter sheet is spirally wound and the overlapping portions of the filter sheet are successively sealed using heat fusion, etc., to form a tubular filter. It is made by cutting it appropriately according to the use and sealing one end.

FIG. 3 shows an embodiment in which a portion of the filter is formed near the venous needle 4.

Here, the filter 1 is heat-sealed at one end into an adapter 3 made of polypropylene resin, for example, which can be fitted into the intravenous needle 4, and the other end is configured to be freely movable within the adapter 3.

Furthermore, by heat-sealing the adapter 3 to the soft vinyl chloride pipe 5, a filter for an infusion set can be created.

In this way, set the bubble point of the filter to 0, 2 k
g/cm2 or less is placed near the intravenous needle of the infusion set, and the infusion set is connected to a bag containing a medicinal solution of physiological saline solution, and the air in the set is completely expelled from the intravenous needle by gravity to the outside air. After the set is filled with only the drug solution, an intravenous needle is inserted into the patient and the infusion is started.

As mentioned above, the filter of the infusion set according to the present invention has a bubble point of 0.2 kg/cm2 or less and is installed near the intravenous needle, so it can be easily removed when the infusion set is dropped from above. Because air passes through the filter, the air inside the set can be completely expelled, similar to infusion sets without filters, and there is no clogging caused by air in the infusion.

Furthermore, the fact that the filter used in the present invention is made as a spiral filter as shown in FIG. 2 is because the overlapped area of the filter sheets is very small compared to the filter shown in FIG. It is very uniform and has excellent sealing strength.

Furthermore, it is extremely simple to manufacture.

[Brief explanation of drawings]

FIG. 1 is a perspective view showing a filter used in the present invention configured to be incorporated into a liquid introduction process. FIG. 2 is a perspective view showing a modification of FIG. 1. FIG. 3 is a partially sectional side view showing an embodiment in which the filter of the present invention is incorporated into a liquid guiding process. FIG. 4 is a cross-sectional view taken along the line A-A when the filter of FIG. 1 is incorporated in FIG. 3. FIG. 5 is a sectional view taken along the line A-A in FIG. 3 in which the filter of FIG. 2 is incorporated. 1...Filter, 2...Seal part,
3...adapter, 4...venous needle, 5...
·····conduit.

Claims (1)

[Scope of Claims] 1. In an infusion set, a filter in which a synthetic resin membrane material is coated on a woven or non-woven fabric to have a pore size of 0.1 to 10μ and a bubble point of 0.2 kg/cm2 or less is attached to an intravenous needle. An infusion set with a filter that is featured by being placed close to it. 2. The infusion set with a filter according to claim 1, wherein the nonwoven fabric is polyester and the membrane material is cellulose acetate.