JPS5811924B2 - Oral composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an oral cavity composition, and more particularly to an oral cavity composition that suppresses the adhesion of dental plaque to teeth.

In general, dental plaque is a dental deposit made up of various bacterial groups, bacterial metabolites, and saliva components, and the acids and proteolytic enzymes produced by oral bacteria in plaque are thought to be a cause of tooth decay and alveolar pyorrhea. ing.

Therefore, in the prevention and treatment of dental caries and alveolar pyorrhea, it is extremely effective to remove dental plaque and to suppress the adhesion of dental plaque to teeth.

While carrying out various studies on means for suppressing the adhesion of dental plaque to teeth, the present inventor surprisingly discovered that a specific saccharide specifically suppresses the adhesion of dental plaque to teeth.

In other words, the mechanism by which plaque adheres to teeth is that saliva components are first adsorbed to tooth enamel and form a thin film on its surface, and then oral bacteria colonize this film and prevent plaque from adhering. is said to occur.

It is thought that the sugar prevents the oral bacteria from colonizing the saliva components and suppresses the adhesion of dental plaque to the teeth.

The present invention was completed based on such knowledge, and
The present invention provides an oral composition containing one or more sugars selected from galactose and oligosaccharides having galactose at the non-reducing end as an active ingredient. It suppresses the adhesion of fluorophores to the teeth and exhibits an excellent preventive effect against cavities and alveolar pyorrhea.

Next, we will show the results of testing the effects of various sugars on the adhesion of dental plaque to teeth.

Test 1 Streptococcus mitis (Str, m1t
is) or Streptococcus sanguis (Str,
Add 20 mg of precisely weighed dry bacterial cells of Sanguis sanguis,
Then, various sugars shown in Table 1 below were added at a concentration of 50 mM relative to the total amount, and cultured at 4°C for 1 hour.

After culturing, the bacterial cells were separated by centrifugation, washed several times,
The amount of saliva adsorbed to the bacteria was measured using the radioactivity of the bacteria as an indicator (the greater the amount of saliva adsorbed, the greater the amount of saliva that binds to the bacteria and the greater the amount of plaque adhering to the teeth).

The amount of saliva adsorbed in the control group, which was treated in the same manner without adding sugar, and the amount of saliva adsorbed in the sugar-added group were compared to calculate the adsorption inhibition percentage for each type.

The results are shown in Table 1. As is clear from these results, galactose and lactose, which is an oligosaccharide having galactose at its non-reducing end, specifically inhibit adsorption of saliva to bacterial cells.

No such effect is observed with fructose or sorbitol, which is commonly used as a humectant in toothpaste.

Test 2 Next, the effects of galactose and lactose on inhibiting the adhesion of human dental plaque to teeth were tested.

15 subjects (male, 2
2 to 30 years old) were divided into three groups (group 1, 5 people), the first group received a mouthwash containing 0.1% galactose (by weight, the same hereinafter) (distilled aqueous solution), and the second group received lactose. A 0.1% compounded mouthwash (distilled water-soluble acid) was used in the third group, and a placebo mouthwash (distilled water) was used in the third group as a control group, 5 times a day for 3 days.

All subjects had their teeth scaled to remove stains before the start of the test, and were not allowed to perform oral cleaning other than mouth reading during the test.

After 3 days, the plaque attached to the teeth was stained with erythrosine.
Quigley and Vine [G, Quigley and J.
, He1n Journal of American
Dental As5ocation, 65°26(
The state of plaque adhesion to teeth was evaluated according to the index method described in [1962].

The average degree of plaque adhesion in the third group (control group) was set as 100,
The average degree of plaque adhesion for each other group was calculated.

The results are shown in Table 2 below.

As shown in Table 2, mouth rinses containing galactose and lactose clearly inhibit the adhesion of dental plaque to teeth in humans.

Thus, in the oral composition of the present invention, saccharides selected from galactose and oligosaccharides having galactose at the non-reducing end are used alone or in combination of two or more.

As the oligosaccharide to be used, the above-mentioned lactose is preferable.

The blending ratio of these sugars can be selected as appropriate depending on the effect, but usually 0.001 to 10%, based on the total amount of the composition.
Preferably, it is 0.1 to 5%.

The oral composition of the present invention can be prepared using conventional methods such as toothpaste, powdered toothpaste,
It can be made into dosage forms such as dentifrices such as liquid toothpaste, oral cleansers such as mouth rinses, troches, and chewing gums.

Other ingredients may be any commonly used ingredients; for example, in the case of toothpaste, wetting agents such as glycerin and sorbitol, calcium diphosphate, calcium carbonate, silicic anhydride, aluminum hydroxide, calcium pyrophosphate, insoluble sodium metaphosphate, etc. abrasives, foaming agents such as sodium lauryl sulfate, sodium acylsarcosinate, and sucrose fatty acid esters, binders such as sodium carboxymethyl cellulose, carrageenan, sodium alginate, and bentonite, sweeteners, flavorings, and others, sodium monofluorophosphate, Contains medicinal agents such as various disinfectants and anti-inflammatory agents.

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 Toothpaste was obtained in a conventional manner according to the following recipe.

Example 2 Toothpaste was obtained in a conventional manner according to the following recipe.

Example 3 Toothpaste was obtained in a conventional manner according to the following recipe.

Example 4 A mouthwash was obtained by a conventional method according to the following recipe.

Example 5 A lozenge was obtained by a conventional method according to the following recipe.

Example 6 Chewing gum was obtained in a conventional manner according to the following recipe.

Claims (1)

[Scope of Claims] 1. An oral composition comprising a sugar selected from galactose and lactose, either alone or in combination. 2 0.001 to 10% by weight of the sugar based on the total amount of the composition
The composition according to item 1 above. 3. The composition of item 1 or 2 above, which is in the form of a dentifrice composition. 4. The composition of item 1 or 2 above, which is in the form of a mouthwash. 5. The composition of item 1 or 2 above, which is in the form of a troche. 6. The above item 1 or 2 which is a chewing gum dosage form.
composition of the term.