JPS5816903B2 - Iyakuchiyuushiyasouchi - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a pharmaceutical injection device, and more particularly to an automatic pharmaceutical injection device capable of dispensing medication according to a selected schedule of intervals of activation and deactivation of a syringe drive motor. .

) Motor-driven syringes for pharmaceutical injection devices are known and are described and disclosed in US Pat. Nos. 3,456,649 and 3,623,474.

However, none of these conventional devices are capable of repeatedly delivering a selected amount of medicament, i.e., 2 cc of medicament every 2 hours for 4 times over an 8-hour period, and do not allow for repetitive schedules. Nor can it be activated based on

Instead, conventional devices deliver a selected amount of medicament only once, during which time a motor simply drives the syringe plunger in a selected straight line to remove the medicament from the syringe barrel. Just let it flow out.

Attempts have also been made to achieve repeatable operation using the above-mentioned conventional device, but this has been extremely difficult due to the limited number of applicable control devices.

For example, in the injection device described in U.S. Pat. No. 3,456,649, the mechanical components undergo a linear movement during operation and are therefore placed in adjustable predetermined positions along the path of this linear movement in order to achieve repeatable actuation. 17. Requires limit switches to start and stop the device as a result of the engagement or physical contact produced by these limit switches.

This control method is expensive and complex and is prone to malfunctions as, in the event of a failure, operative contact occurs between the movable member and the control switch.

This results in the delivery or injection of too much medication, which has the disadvantage of endangering the health of the patient.

It is an object of the present invention to provide a medical injection device which obviates the above-mentioned and other disadvantages of the prior art.

In particular, it is an object of the present invention to be able to carry out repeated actuation injections, driven by a motor whose actuation is uniform during this repetitive cycle and which is very reliable in achieving the required performance of such repetitive actuation. A medical injection device including a syringe is provided.

The pharmaceutical injection device of the present invention includes a rotary motor operatively arranged to cause the syringe plunger to undergo linear motion or a pharmaceutical injection stroke; a pulse generator for generating pulses for each rotational movement; and electrically connected to receive each transmission of pulses and for initiating operation of the syringe drive motor and transmitting a selected number of the pulses to the motor. a pulse counter operatively connected to continue the operation of the motor while the pulse counter continues to operate the motor; It is characterized by control.

DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of the invention will be described in detail with reference to the accompanying drawings;
Further clarify its purpose, structure and benefits.

The drawings, especially FIGS. 1 to 3, show the structure of the mechanical parts of the medical injection device 10.

Intended use of the injection device 10 is accomplished by intravenously injecting the syringe 12 with a selected amount of the medicament according to a selected schedule.

That is, it is not possible to inject slowly and evenly into the patient over a long period of time, but when the patient has not yet been administered the drug and the patient's body may react to the administered drug, the patient may be injected in a relatively short period of time, Some medications require subsequent administration over a long period of time.

For example, certain types of anticoagulants must then be injected at intervals and even at intermittent intervals in order to produce the desired effect on the blood.

The device 10 can be advantageously used for this purpose.

A selected amount of the drug solution can be injected from the syringe 12 through the tube 15, and the end of the tube 15 can be connected to a needle or other device (not shown) to enable intravenous injection of the drug solution into the patient.

Additionally, the time for injecting a selected amount of drug or medicament, such as 1 cubic starch or 1 cc, can be relatively short, e.g., less than 1 minute, and then the same amount of medicament can be injected in 2 hours. Alternatively, subsequent injections can be given at 2 hour intervals.

Therefore, it is necessary to inject 1 cc of the drug every 2 hours.6
Assuming that the syringe 12 is filled with cc of medication, injections at this interval can be achieved by properly setting the controls of the device 10.

These assumed selected values can of course be changed, and the present invention can easily be adapted to inject 2 cc of medicament every 6 hours, so they are not limited to these values. .

The importance of the operating state of the injection device 10 is that the administration of medicament can be effected according to a selected schedule of successive intervals of activation and inactivation.

In one preferred embodiment of the device 10 shown in FIGS. 1-5, the device 10 includes a syringe 12 of the type having a plunger 14, as described above.
The linear displacement of 4 indicates the amount of medication to be injected from the chamber of the syringe 12 through the tube 15 into the patient.

The driven member 18 moves the plunger 14 in a straight line.
The driven member 18 has a threaded member 20 mounted on a lead screw 22 as shown in FIG. 3, and the lead screw 22 is rotationally driven by a motor 24.

That is, the motor 24 is operatively coupled to rotationally drive the lead screw 22, which has threads 26 machined at a uniform pitch along its entire length to provide a path for linear movement of the plunger 14. are arranged in y-parallel, and in this embodiment are arranged on the underside of the plunger 14, so that the pushing head 16 has an upright rond protruding from a slot 30 drilled in the top plate 32 of the housing 34 of the device. It can be easily attached to 28.

A resilient seal 36 having a central slit 38 is suitably mounted over the slot 30 to prevent the interior of the housing box 34 from becoming contaminated with dirt or other contaminants.

In order to complete the structure of the driven member 18 and to prevent the driven member 18 from rotating simultaneously with the rotation of the lead screw 22,
A body member 40 is provided that prevents rotational movement of the body member 40 by having a forward end of the body member 40 project through an opening 42 drilled in a fixed suspension mounting member 44, the fixed suspension mounting member 44 being connected to the motor 24 described above. It also acts to support.

In operation, the lead screw 22 is rotationally driven and the threaded member 20 threadedly engaged with the lead screw 22 is advanced along the entire length of the lead screw 22.

Rotation of lead screw 22 in one direction advances threaded member 20 toward motor 24 and rotation in the opposite direction advances screw member 20 away from motor 24.

The head 16 moves in response to the threaded member 20, and since the head 16 is in pressure engagement with the end of the plunger 14 as shown at 46, the one-way movement straightens the plunger 14 within the barrel of the syringe 12. movement, thereby dispensing the medicament from the interior chamber of the syringe 12 in response to the linear movement of the plunger 14.

To hold the syringe 12 against movement during actuation of the plunger 14 by the head 16 of the follower member 18, the laterally extending tongue 48 of the syringe 12, which normally acts as a finger grip, has a portion attached to the mounting plate 52. The mounting plate 52 is disposed within a retaining recess 50 drilled in the top plate 32 and is suitably attached to the top plate 32 at a predetermined position.

L-shaped rod 54 acts as a clamp to hold the barrel of the syringe to mounting plate 52 and lock screw 561/
C is held in place by threading adjustment of the locking screw 56 to engage the flat surface 58 of the clamp or rod 54.

Lead screw and follower drive mechanisms have previously been used to linearly move the plunger of a syringe in automatic pharmaceutical injection devices; The present device 10 is unique and has never been previously known or proposed.

In particular, this control mechanism consists of using the rotational movement of lead screw 22 as a measure of the duration of activation of drive motor 24.

Therefore, major drawbacks of the prior art can be eliminated.

For example, when the drive motor of a conventional device is operated at selected time intervals, non-uniform A large amount of medicine is administered.

The applied load on the drive motor is also variable, which also results in non-uniform doses of medicament being administered.

Even during a particular time interval, conventional motors deliver more of a less viscous medicament than a more viscous medicament.

Therefore, in such conventional devices, in order to uniformly administer the medicine/drug, it is necessary to adjust the control in consideration of the different viscosity of the medicine to be administered.

Furthermore, after long-term use, conventional devices wear out their bearings or other moving parts, and this wear has an effect even during shutdown intervals, and this change in wear resistance results in non-uniform doses of medication being administered. I will do it.

Significantly different from what has been described above, the injection device 10 of the present invention
A unique feature of the is that the distance between the operations of the drive motor 24 is
2 is related to the number of rotational movements that occur, and is independent of the time taken to accomplish these number of rotational movements.

Each rotational movement of lead screw 22 advances threaded member 20 by a uniform amount as indicated by the uniform pitch of threads 26, and uniform advancement of threaded member 20 also uniformly advances suppression head 16, thus displacing the syringe. Needless to say, the plunger 14 should be moved linearly uniformly.

At this point, it is appropriate to indicate how the amount of medicament administered during each injection is related to the number of rotations of the lead screw 22.

As shown in FIG. 2, a scale 62 is provided along the edge 60 of the top plate 32, the scale 62 is indicated by increasing numbers starting at "O", each number representing a uniform advance or extension of the thread 26. The starting point corresponding to the forward distance caused by a uniform pitch "
The uniform advance is determined by the number of revolutions of the lead screw 22.

Therefore, considering that each rotational movement of lead screw 22 moves threaded member 20 by the pitch of threads 26, linear distance 64 is achieved in 10 revolutions, twice that distance in 20 revolutions, and so on. The same is true.

Further, if it is desired to administer 2 cc of medicament with each injection, this can be done by grading the barrel of syringe 12 by laying it along graduation 62, as shown in FIG. The volume of 2cc is 62 on the scale.
Since it extends from the 0 point above to the point 65 corresponding to the point 27 on the scale, it requires r2727 rotations.

Furthermore, if it is desired to administer 2 cc of these drugs every 2 hours, then the 2 cc of these drugs built into the device 10
The timing control mechanism should be set appropriately to indicate the dosing schedule.

As is clear from what has already been explained, the medicament is applied to the patient, ie, the medicament is administered, only while the drive motor 24 is in operation.

As shown in FIG. 2, the motor on timer 66 includes two control knobs or selectors 68, 70, each displaying a number 72 from "1" to "10" around it.

Then, in a manner that will be better understood, 2 cc of medical birch as described above is dispensed by rotating lead screw 22027 as described above, setting selector 68 to number "2" and setting selector 70.
This 2 cc of medicament is set in the operating state of the device 10 by setting the number "7" to the number "7", and the combined action of setting the selectors determines the number of rotational movements of the lead screw 22 during each actuation of the drive motor 24. Select "27".

Another timing device 74 is a device for controlling the motor off time, and this timer is an implementation used to indicate the operating state of the device 10 by placing numbers 78 from "l" to "10" around the circumference of its selector 76. In the example, drive motor 24
The inactive time is two hours between injections, so selector 76 is moved to the proper relationship number "2" for this result to occur.

The method for producing this result will now be described.

4 and 5 in conjunction with FIGS. 1-3, it will be explained how the device 10 is controlled by the rotational movement of the lead screw 22. FIG.

The drive motor 24 also mounts a radially oriented striking member 30 to the distal end of the lead screw 22 and simultaneously drives the striking member 80 in rotation with the lead screw 22.

As best seen in FIG. 4, a switch contact arm 82 is mounted adjacent to the striking member 80 and specifically in the path of rotational movement of the striking member 800, so that during each rotational movement the striking member 80 actually engages this switch contact arm 82. Make physical contact.

This physical contact or engagement of striking member 80 with switch contact 82 actuates switch 84 .

In particular, the switch 84 is part of the pulse generation circuit,
Activation of switch 84 closes this circuit and generates an electrical pulse which is transmitted to a pulse counting circuit provided on printed circuit board 86 (see FIG. 3).

In more detail with respect to the circuit diagram of FIG. 6, operation of the drive motor 24 is initiated by the action of the pulse counting circuit on the printed circuit board 86, during which time the drive motor 24 is sent a selected number of pulses to the drive motor. continues to operate the drive motor, and the number of pulses selected in the illustrated embodiment is "27" pulses.

The selected number of pulses, or rotational movement of the lead screw 220, causes the syringe plunger 14 to move linearly as described above, forcing two CCs of medicament from the barrel of the syringe 12.

When the lead screw 22 makes the twenty-seventh rotational movement, the device 10
The electrical control member produces three operating states.

Its first action is to reset the motor on timer 66 to a "0" setting.

The second action is to terminate the operation of drive motor 24.

The third operation is the start of timing operation of the motor off timer 74.

As in the case of motor on timer 66, timer T
Timer 74 is activated by sending pulses to lead screw 22, and according to the illustrated embodiment, this timer receives any number of pulses generated, which pulses are not caused by rotation of lead screw 22, but by the oscillator. or other pulse source, but the generation of this pulse corresponds to the passage of two hours, which is the selected time interval during which one motor 24 is inactive.

At the end of the two hour time interval, the motor 24 resumes its operation and, by actuating the switch 84, the striking member 80 is again pulsed as a function of the rotational movement of the lead screw 22, which is rotationally driven by the motor 24. It brings about action.

When the "27" pulse is again transmitted and counted by the pulse counting circuit, the action of motor 240 causing syringe plunger 14 to cause a medicament injection stroke is again terminated.

Eventually, the last 2 cc of medicament will be dispensed from the barrel of syringe 12, thus requiring refilling of the syringe barrel with medicament.

In order to indicate this condition, as shown in FIG. 91, thus indicating that the end of the medicament injection step 94 has been reached.

In addition to the timing control system comprising the motor on timer 66 and the motor off timer 74, the injection device 10 may be provided with a control system that allows the injection device to override these timing devices and inject the medicament without following the selected schedule. be.

This allows drugs or medicines to be injected in case of emergency.

The control device has a pushbutton 96 that can itself be operated;
When this pushbutton 96 is depressed, even if the device 10 is under the control of the motor off timer 74, the controller is electrically actuated to immediately begin operation of the drive motor 24.

The device 10 also includes an on-off master switch 98.

Flashing light 1 as part of the control device for the device 10
3. The lights 10 are provided with a visual signal in the form of 00.
0 is energized by each pulse sequentially sent to timer 66.7B, and during motor on time and motor off time device 1
It functions to indicate the operation of 0.

To complete the device 10, as shown in FIG. In the event of successive occurrences, the driving connection between the motor 24 and the lead screw 22 is severed.

The generation of the counter pressure is transmitted to the pressing head 16, and the motor 2
4 acts as a force that tends to push the lead screw 22 in a direction away from the lead screw 22.

In response to this force, the clutch 136 of the coupling 90 will break the driving connection between the drive member and the driven member, and thus the driving connection between the motor 24 and the lead screw 22.

The clearance for this slight rearward movement of the lead screw 22 is created by the compression of the internal spring 138 as the drive notch 140 at the end of the lead screw 22 moves relative to the drive pin 142.

The drive notch 140 and the drive pin 142 simultaneously drive the striking member 30 when the drive motor 24 rotates the lead screw 22 .

FIG. 6 shows an exemplary electronic circuit wired or otherwise suitably embedded in a printed circuit board 36. FIG.

The circuit of FIG. 6 acts as a motor on timer 66 and a motor off timer 74, in both cases providing a timing effect and suitably utilizing this effect to transmit electronic pulses.

In effect, this portion 110 of the circuit of FIG. 6 produces the pulse counting function for device 10 as described above.

This action is performed by batteries or line voltage.

That is, the device 10 can be used in a wrapped position around a patient's arm; in the illustrated embodiment, the device 10 is portable and powered by a battery (not shown).

Alternatively, the device 10 may be used under the patient's pillow, in which case it would be powered by a conventional power source.

When so done, the power delivered to the unit activates an electrical oscillator or pulse generator 112.

Pulse oscillator 112 may be any one of several types and generates pulses that reach a selected peak voltage on a selected time base.

The output or pulses from oscillator 112 are provided to counting circuit 110 .

Counting circuit 110 may also be one of several types or so-called decimal counting circuits, which are readily available from major companies such as RCA.

For purposes of the present invention, the operation of the decimal counter shown at 114 in FIG. It is sufficient to have the above output.

The operation of pulse counter 114 is such that it activates each of these outputs sequentially during each actuation cycle and then repeats the actuation cycle.

Therefore, output "0" is activated first, then output "1" is activated,
Next, output "2" etc. are activated.

When the output "10" is activated, it creates an electrical connection to the second decimal counter, indicated as "second pulse counter" 116, and as in the case of counter 114, the second pulse counter 116
is activated.

During this time, the cycle of operation of counter 114 is repeated.

Thus, virtually all of the "10" outputs of the first counter 114 complete the successive pulse generation and produce one pulse which is sent to the next counter 116 via conductor 118.

In this way a large number of pulses can be counted, with a selected number of counters 114, 116 being electrically connected to each other to act as a timing device, with the two units N14, 1
16 is used as a motor on timer 65 to measure the time for operating the drive motor 24 of the syringe 10.

Of course, a number of these units may be used in cooperative relationship to produce the motor off timer 74.

Continuing with the illustrated embodiment described above, the selection of 27 pulses for the operating time of the drive motor 24 is achieved by adjusting the selector 68 so that the wiper 120 receives the output "2" of the second pulse counter 116. The selector 70, particularly the wiper 122 of the selector 70, is electrically connected to the first
It is electrically connected to the output “7” of the pulse counter 114.

However, this can also be reversed and such a configuration is provided for motor-on operation for intervals of 27 pulses.

As already explained, the output of the second pulse counter 116 "
It is necessary to send two pulses to the second pulse counter to achieve an excitation of 2'', but each of these pulses causes an excitation of a total of 10 outputs of the first pulse counter 114, i.e. 10 In other words, it is necessary to generate 20 output pulses.

Therefore, when the first pulse counter 114 starts on the third continuous cycle of counting operation and when the output "7" is energized on the seventh transmitted pulse, it is the second An electrical connection is made to the two outputs "2" and "7".

In this way, the control circuit 124 is closed and the control circuit 1
24 sends a pulse to motor off switch 126, which causes motor 24 to stop driving.

It also sends a pulse to the starting circuit 131 of the motor off timer 74 through the conductor 128 to start the operation of this timer.

The wiper associated with selector 68, 70 can be rotated to electrically connect outputs other than the particular output designated.

This is illustrated in FIG. 6, where the range of wiper positions is indicated by wiper travel path 130.

Further, as shown in FIG.
32 to a reset control circuit 134 which is operative to reset the motor off timer 74 to "0" at the end of a period of motor 24 inactivity.

There are many ways to do this.

For example, one method is to activate a flip-flop switch with the last pulse of this period.

Such a switch is a standard component that can be easily purchased on the market from companies such as RCA, and when actuated by this last pulse, actuating this flip-flop switch as is commonly known. Close the circuit to the motor and simultaneously reset this counting circuit to its "0" setting.

As a result, when the motor operation is finished, this counting circuit 11
0 is a state where counting starts again from "0".

From the description of the mechanical configuration of the device 10, the generator 1
12 is adjusted to a pulse generating operative state by striking member 80 which physically contacts switch 84 during each rotational drive of lead screw 22 and produces pulses counted by motor on timer 66.

However, when the drive motor 24 is inactive, the pulse generator 112
operates like an oscillator and sends pulses to a counting circuit such as 110, which performs the same function when the motor is not running as it does when the motor is running.

Since the time when the drive motor 24 is inactive is considerably longer than the time required to inject the medicine, the pulse counting circuit 11
0, another pulse counter is provided in addition to the two pulse counters 114 and 116.

However, even when the number of pulse counters is increased, at least the first two counters are divided into counters 114 and 11 to avoid duplication.
It can be set to 6.

The basic use of the device 100 is to inject a predetermined amount of medicine on a timed schedule.

However, it is not strictly limited to this use;
The device 10 may be operated by a separate monitoring device separate from the timing devices 66, 74 described above.

In other words, for example, a heart patient may have a monitoring device that indicates when the patient is in a medically difficult situation.

Such monitoring device is used to generate a pulse to initiate operation of motor 24 and inject a predetermined amount of medicament to overcome a patient condition sensed by this monitoring device that requires the medicament. Do it like this.

As is clear from the above, the medical injection device 10
allows the medicament to be injected according to a selected schedule of successive time intervals of activation and deactivation of the drive motor 24.

Also, these equal time intervals are controlled as an effect of each rotational drive, rather than relying on completely manual timing effects as is done in the prior art.

Therefore, during the selected time unit, the device 10 is not subject to changes that affect performance.

Changes that affect this performance include changes in voltage, changes in the viscosity of the medicine to be administered, changes in frictional resistance inside the motor itself,
There are other factors that can adversely affect the functioning of devices of the type described and cause non-uniform performance.

What has been described above is an embodiment of the present invention.
It goes without saying that the present invention is not limited to these embodiments and can be modified in various ways within the scope of the claims.

Next, the gist and embodiments of the present invention will be listed.

■) A syringe that administers medicine by linear movement of a plunger, a fixing mechanism that fixes the syringe connected to a patient in order to administer medicine to the patient, and a fixed mechanism that has a uniform pitch arranged parallel to the linear movement path of the plunger of the syringe. a rotatable lead screw having threads; a push mechanism mounted on the lead screw for engaging a plunger of the syringe and advancing the lead screw;
a motor disposed to rotationally drive the lead screw to produce forward motion of the pushing mechanism and linear movement of the syringe plunger; a radially oriented striking member mounted on the lead screw; a pulse generating switch disposed in the path of rotational movement of the striking member adjacent to the main hitch so as to be engageable with the striking member to produce electrical pulses during rotation;
a pulse counting device electrically connected to receive each pulse transmission and operatively coupled to the motor to operate the motor during a period of transmitting a selected number of pulses to the motor.

Pharmaceutical injection device, characterized in that it administers the medicament by a linear movement of the plunger of the syringe as a function of the number of rotational movements of the motor counted by a pulse counting device.

(2) having a separate timing device operatively connected to the motor to initiate activation of the motor after a selected period of motor inactivity, administering the medicament according to a selected schedule of successive intervals of motor activation and deactivation; The pharmaceutical injection device according to item 1 above.

□(3) A clutch is interposed to provide a driving connection between the motor and the lead screw, and a selected limited linear motion is made to disengage the lead screw from the clutch such that the rotational movement of the lead screw is stopped by the motor. 2. The pharmaceutical injection device according to item 2, wherein a mechanism is provided for attaching the lead screw so that administration of the medicine can be stopped in an emergency.

(4) the timing device is of the type actuated by the transmitted pulses in the same way as the pulse counting device, and there is a visible alarm device connected to the timing device and the pulse counting device to be actuated by each transmitted pulse; 3. A medical injection device according to claim 2, wherein the visual alarm device is operative to indicate the operating status of the medical injection device.

(5) Providing a scale that calibrates the linear movement of the syringe plunger by an increasing number of pulses during the rotational operation of the motor, facilitating the volume of medicament to be administered to the selected number of pulses counted by the pulse counting device. 5. Pharmaceutical injection device according to item 4, characterized in that it can be associated with

[Brief explanation of the drawing]

The figure shows an embodiment of the medical injection device of the present invention.
2 is a plan view of the device of FIG. 1 showing the method of relating the amount of medicament to be injected to the electrical pulses generated during its operation; and FIG. 3 is a plan view of the device of FIG. 1. 4 is a sectional view taken along line 4-4 in FIG. 3 showing the structure of the pulse generator used in the device shown in FIG. 3, and FIG. 6 is a cross-sectional view taken along line 5--5 in the drawings, and FIG. 6 is a wiring diagram showing the electrical components used to control the operation of the mechanical components of the apparatus of FIG. 10...Medical injection device, 12...Syringe, 14...Syringe plunger, 24...
...Motor, 66...Motor on timer, 74
...Motor off timer, 80...Breaking member, 82...Switch contact, 84...
・Switch, 110...Pulse counting circuit, 11
2... Pulse generator, 114... First
Pulse counter, 116...Second pulse counter.

Claims (1)

[Claims] 1. A syringe that administers medicine by linear movement of a plunger, a fixing mechanism that fixes the syringe connected to a patient in order to administer the medicine to the patient, and a screw with a uniform pitch arranged parallel to the linear movement path of the plunger of the syringe. a rotatable lead screw having a thread; a suppression mechanism mounted on the lead screw for engagement with a syringe plunger and advancement along the lead screw; forward movement of the pressure mechanism and linear movement of the syringe plunger; a motor disposed to rotationally drive the lead screw to produce a radially oriented striking member mounted on the lead screw and engaged with the striking member to produce electrical pulses during each rotation of the lead screw; a pulse generating switch disposed proximate the lead screw in the path of rotational movement of the striking member to enable electrical connection to receive transmission of each pulse and transmit a selected number of pulses to the motor; a pulse counter coupled to the motor to operate the motor during the period of time for administering the medicament by linear movement of the plunger of the syringe as a function of the number of rotational movements of the lead screw counted by the pulse counter; A pharmaceutical injection device characterized by: