JPS5827247B2 - Treatment adhesive tape or sheet - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a therapeutic adhesive tape or sheet suitable for treating various skin diseases, as well as for anti-inflammatory and analgesic purposes.

Increasing the water content of the stratum corneum for transdermal absorption of drugs
Since not only the hair follicle-sebaceous gland system but also the absorption path that passes directly through the stratum corneum can be used directly, effective skin absorption can be achieved.

For this reason, occlusive bandage therapy (ODT therapy), which involves applying external medicine such as ointment to the skin and covering it with an impermeable film to ensure effective drug absorption, has recently become popular as a treatment for skin diseases. .

However, this occlusive bandage therapy is not only troublesome to attach to the affected area, but also bulky, easy to peel off, and is difficult to apply when the affected area is large or has a complicated shape. It had drawbacks such as being difficult to use.

In order to improve this drawback, for example,
As seen in the publication, an adhesive tape has been proposed in which a pressure-sensitive adhesive layer containing a drug is provided on one side of an impermeable film.

Such conventional adhesive tapes have been manufactured by applying a drug together with a suitable solvent to the surface of a pressure-sensitive adhesive layer, or by mixing the drug into a pressure-sensitive adhesive solution and applying it.

Therefore, according to the former method, the drug is simply applied to the surface of the pressure-sensitive adhesive layer, which has the disadvantage that it is rapidly absorbed into the affected area, and according to the latter method, the drug is simply applied to the surface of the pressure-sensitive adhesive layer. Since it is dispersed inside the drug layer, it has the disadvantage that it takes a very long time for it to be absorbed into the affected area, and in any case, it has been difficult to gradually absorb it into the affected area at a desired rate.

SUMMARY OF THE INVENTION In view of the above-mentioned drawbacks of the conventional art, it is an object of the present invention to provide a therapeutic adhesive tape or sheet that is easy to use and is capable of gradually absorbing a drug into an affected area at a desired rate.

The gist of the present invention is a therapeutic adhesive tape, characterized in that a porous pressure-sensitive adhesive layer is provided on one side of a base film, and a drug is absorbed into the pores of the adhesive layer. Or it exists on the sheet.

The base film used in the present invention includes polyethylene film, ethylene-vinyl acetate copolymer film,
A flexible polyvinyl chloride film, a cellophane film, etc., or a flexible film obtained by surface-treating these with corona treatment or the like is preferably used.

The thickness of the base film is preferably in the range of 50 to 100 microns.

Pressure-sensitive adhesives used in the present invention include rubber-based pressure-sensitive adhesives, such as natural rubber, isoprene rubber, styrene-butadiene rubber, etc., to which tackifying resins, softeners, etc. are added, and acrylic-based pressure-sensitive adhesives. copolymers containing acrylic acid alkyl esters, methacrylic acid alkyl esters, etc. as main components; other silicone-based pressure-sensitive adhesives;
Urethane pressure sensitive adhesives and the like are preferably used.

When using an acrylic pressure-sensitive adhesive, it is particularly preferable that the alkyl group has 4 to 12 carbon atoms.

As the drug used in the present invention, adrenocortical hormones such as dexamethasone, frednisolone, hydrocortisone, hydrocortisone acetate, betamethacin, other anti-inflammatory agents, antihistamines, bactericidal agents, etc. are used as appropriate depending on the purpose.

In the present invention, a porous pressure-sensitive adhesive layer is provided on one side of the base film.

Typical formats for porous pressure sensitive adhesive layers are as follows.

A pressure-sensitive adhesive solution is applied onto the base film, immersed in a poor solvent in a semi-dry state, and then heated and dried to form a porous pressure-sensitive adhesive layer.

The poor solvent in this case is methanol, ethanol, water, etc. A mixture of these may be used, or a small amount of a good solvent may be added to adjust the solubility.

The porosity of the pressure-sensitive adhesive layer is determined by the time from application of the pressure-sensitive adhesive solution to immersion into a poor solvent, that is, the amount of good solvent remaining in the pressure-sensitive adhesive layer at this time, and the amount of good solvent remaining in the pressure-sensitive adhesive layer at this time. It can be controlled by the type of solvent.

It is preferable to properly crosslink the pressure-sensitive adhesive, since this will prevent the adhesive from remaining on the affected area when used.
Crosslinking can be carried out using diincyanate, metal salts, jepoxy, electron beam irradiation, and the like.

In addition to the above methods, methods for forming a porous pressure-sensitive adhesive layer include a method using a foaming agent, a method in which water is dispersed in a solution of a pressure-sensitive adhesive, and then applied and dried. A method of mixing a substance that dissolves in water, applying it, and then extracting it using a book can be adopted as appropriate.

In the present invention, a drug is adsorbed onto the porous pressure-sensitive adhesive layer.

Adsorption of the drug can be carried out in the usual manner, that is, by dissolving the drug in a suitable solvent and dipping an adhesive tape or sheet provided with a porous pressure-sensitive adhesive layer therein, or by dissolving the drug in the solvent. A method of coating or spraying a drug solution on a porous pressure-sensitive adhesive layer is appropriately employed.

Then, the drug enters into the pores of the porous pressure-sensitive adhesive layer and is adsorbed.

The amount of drug adsorbed on the porous pressure-sensitive adhesive layer varies depending on the type of drug, but is preferably about 1 to 100 μm per crtt of the adhesive layer.

When the therapeutic adhesive tape or sheet of the present invention is applied to the affected area, the drug adsorbed to the porous pressure-sensitive adhesive layer is gradually released over a period of, for example, 5 to 20 hours, and is effectively treated over time. Absorbed through the skin.

The drug release rate can be controlled to a desired value depending on the application, the type of drug, etc. by adjusting the pore diameter and number of the porous pressure-sensitive adhesive layer.

As mentioned above, the therapeutic adhesive tape or sheet of the present invention has a porous pressure-sensitive adhesive layer provided on one side of the base film, and the drug enters and is adsorbed into the pores of the adhesive layer. It is easy to use and allows the drug to be absorbed into the affected area at a desired rate.

Examples of the present invention are shown below.

Example 1 2 Ethylhexyl acrylate 28 parts by weight Maleic anhydride 1 part by weight Styrene
1 part by weight benzoyl peroxide 0.1 part by weight ethyl acetate
Pour 70 parts by weight of the above composition into a reaction vessel,
Polymerization was carried out at 80° C. for 20 hours in a nitrogen stream to prepare a pressure-sensitive adhesive solution.

Next, an ethylene-vinyl acetate copolymer film (vinyl acetate content: 10% by weight) having a thickness of 70 μm was subjected to corona discharge treatment to obtain a base film.

After adding o and i parts by weight of zinc acetate to the above pressure-sensitive adhesive solution, it was applied to one side of the base film to a thickness of about 100μ, and after drying at 40°C for 30 minutes, the weight ratio was 50:50.
immersed in a mixture of methanol and water, then heated at 70℃ for 2 hours.
After drying for a while, a porous pressure-sensitive adhesive layer (approximately 50μ thick) is formed.
) was obtained.

An ethanol solution containing prednisolone was sprayed onto the surface of the porous pressure-sensitive adhesive layer of this adhesive tape to obtain a therapeutic adhesive tape containing 40 μda of prednisolone per 1 c4.

This therapeutic adhesive tape was applied to the affected area, and after 3 and 6 hours, it was removed and the amount of prednisolone remaining on the therapeutic adhesive tape was analyzed.

As a result, 18μg after 3 hours and 5μ2 after 6 hours.
of prednisolone remained, and it was confirmed that the prednisolone adsorbed to the porous pressure-sensitive adhesive layer was gradually released and absorbed into the affected area.

For analysis of predzolone in the therapeutic adhesive tape, the tape was extracted with methanol, the extract was separated using liquid chromatography, and then quantified using an ultraviolet absorption spectrometer.

Example 2 The same pressure-sensitive adhesive solution as in Example 1 was applied to one side of the base film in the same manner, dried at 40°C for 10 minutes, and then immersed in a mixture of methanol and water at a weight ratio of 70:30. Then, it was dried at 70° C. for 2 hours to obtain an adhesive tape provided with a porous pressure-sensitive adhesive layer (thickness: about 50 μm).

An ethanol solution containing prednisolone was applied to the porous pressure-sensitive adhesive layer of this adhesive tape to obtain a therapeutic adhesive tape containing 42 μg of prednisolone per crA.

This therapeutic adhesive tape was applied to the affected area and removed after 6, 12, and 24 hours, and the amount of prednisolone remaining in the adhesive tape was analyzed.

As a result, 30 μg of prednisolone remained after 6 hours, 18 μg after 12 hours, and 3 μg after 24 hours, and the prednisolone adsorbed on the porous pressure-sensitive adhesive layer gradually decreased compared to Example 1. It was confirmed that it was released at a relatively slow rate.

Claims (1)

[Claims] 1. A therapeutic adhesive tape, characterized in that a porous pressure-sensitive adhesive layer is provided on one side of a base film, and a drug enters and is adsorbed into the pores of the adhesive layer. Or a sheet. 2. The therapeutic adhesive tape or sheet according to claim 1, wherein the amount of the drug adsorbed into the pores of the adhesive layer is 1 to 100 μm per crA of the adhesive layer.