JPS582990B2 - Aerosol saves - Google Patents

Description

[Detailed description of the invention] The present invention relates to aerosol compositions.

More specifically, the present invention relates to a water-alcohol-based aerosol composition that has excellent emulsion stability.

Conventionally, many products such as various cleaners such as glass cleaners and furniture cleaners, deodorants, insecticides, and cosmetics have been used as aerosol products.

In order to improve compatibility with the propellant, such aerosol products generally use a solvent such as lower alcohol as a base, and the active ingredient or medicinal ingredient is dissolved and dispersed in this solvent. The base aerosol itself is flammable and dangerous, and the propellant must be an expensive non-flammable gas such as chlorofluorocarbon gas, and depending on its use, the active ingredient is insoluble in solvents such as ethanol. Sometimes it is necessary to use one.

Therefore, attention has recently been focused on safe and economical water-based or water-alcohol-based aerosol products that can use flammable but inexpensive lower hydrocarbons as propellants.

However, since water and propellant are mutually insoluble and have different specific gravities, it is very difficult to make them into an aerosol.

That is, in aerosol products made of a combination of a water-based stock solution and a propellant, it is extremely difficult to mix the stock solution and the propellant uniformly, and the stock solution and the propellant tend to separate into two layers.

In order to improve this drawback, there is a method of improving the emulsification state between the stock solution and the propellant by using various surfactants such as polyoxyethylene alkyl ether type or polyhydric alcohol aliphatic ester type as an emulsifier. Although it has been proposed, satisfactory results have not always been obtained.

Furthermore, active ingredients and medicinal ingredients include various water-insoluble substances, and in order to stably disperse such substances, it is better to use methanol, ethanol, impropanol, etc. in water than to prepare a water-based stock solution. A water-alcohol based stock solution to which a lower alcohol has been added is even more preferred.

However, in such water-alcohol-based aerosol compositions, the emulsified state of the propellant and stock solution breaks down more quickly than in the case of only water, especially in water-alcohol-based aerosol compositions containing 20 to 80% by weight of alcohol. However, there were no surfactants that had excellent emulsifying performance between the stock solution and the propellant.

The present inventors completed the present invention as a result of research aimed at solving these drawbacks and obtaining a water-alcohol-based aerosol composition having excellent emulsion stability against propellants.

That is, the present invention consists of a stock solution containing an active ingredient or medicinal ingredient and a propellant, and the mixing ratio of the stock solution and the propellant is 9 by weight.
5/5 to 20/80, the alcohol content of the stock solution is 20 to 8
In an aerosol composition consisting of a liquid in which an active ingredient and/or a medicinal ingredient is dissolved or dispersed in an aqueous solution of an alcohol having 3 or less carbon atoms containing 0% by weight, an average number of moles of ethylene oxide added to the stock solution is 25 to 150 castor. This is an aerosol composition characterized by containing an ethylene oxide adduct of oil or hydrogenated castor oil as an emulsifier.

In the present invention, a water-alcohol-based aerosol composition is a stock solution in which medicinal ingredients and other necessary ingredients are dissolved or dispersed in an aqueous solution of a lower alcohol having 3 or less carbon atoms, such as methanol, ethanol, or isopropanol. The concentration of the alcohol aqueous solution can be appropriately selected in the range of 20 to 80% depending on the types of medicinal ingredients and other necessary ingredients and their added amounts.

If it is less than 20%, it is generally insufficient to dissolve and disperse the active ingredients or medicinal ingredients, and if it is more than 80%, it is difficult to obtain a satisfactory emulsified state even if an emulsifier is used.

In addition, the propellant used in the present invention is not particularly limited, and in addition to fluorocarbon gases such as dichlorodifluoromethane and trichloromonofluoromethane, flammable propellants that cannot be used in conventional solvent-based aerosol compositions may also be used. lower hydrocarbon gases such as propane, butane,
Liquefied petroleum gas (hereinafter abbreviated as LPG).

) It is economically advantageous because it can be used at a lower cost than chlorofluorocarbon gases.

The mixing ratio of the above-mentioned stock solution and propellant in the aerosol composition of the present invention is 95/5 to 20/80 by weight, and if the proportion of the propellant is less than this range, the performance as an aerosol will deteriorate; In addition, in the aerosol composition of the present invention, where the proportion of the stock solution is too small and uneconomical if it exceeds this range, in addition to the above-mentioned stock solution and propellant, castor powder having an average added mole number of ethylene oxide of 25 to 150 is used as an emulsifier. Using ethylene oxide adducts of oil or hydrogenated (hardened) castor oil.

If the blending ratio is 0.05 to 1.0% by weight based on the stock solution, an aerosol composition in a good and stable emulsified state can be obtained.

The castor oil or the ethylene oxide adduct of hydrogenated castor oil according to the present invention can be obtained by a known method (see, for example, Industrial Chemistry Magazine Vol. 53 (1950), p. 431).

Generally, in the presence of an acid or alkali catalyst under heat and pressure (10
It is obtained by adding ethylene oxide to castor oil or hydrogenated castor oil at 0 to 200°C and 1 to 5 kg/cm2).

The average number of moles of ethylene oxide added is the number of moles of ethylene oxide absorbed when ethylene oxide gas is introduced in the presence of an alkali catalyst to one mole of castor oil calculated as consisting only of ricinoleic acid triglyceride.

In the present invention, by blending an ethylene oxide adduct having an average addition mole number of 25 to 150 as an emulsifier in the above stock solution, excellent emulsion stability as shown in the experimental examples and examples can be obtained.

In water-based aerosol compositions, nonionic surfactants such as polyoxyethylene alkyl ether and polyoxyethylene sorbitan fatty acid ester have traditionally been used as emulsifiers; In the case of an aerosol composition, it was completely impossible to obtain a stable emulsified state, but with the aerosol composition of the present invention, a good and stable emulsified state can be obtained.

These features of the present invention will be illustrated below using experimental examples.

Experimental example stock solution (ethanol/water - 50/50) 60% by weight propellant 40 Add 0.5% by weight of various surfactants shown in the following table as emulsifiers to the above stock solution, and add this to the above ratio in a transparent container. An aerosol composition was prepared by filling together with a propellant so that the emulsion stability was investigated.

The test method was to shake the above composition for 15 seconds, then leave it at room temperature, and measure the time until the emulsified state was broken and the composition separated into two layers.

Propellants include LPG and dichlorodifluoromethane (
F-12) was used.

The results are shown in the table below. ×: Separated 5 minutes after shaking Δ: Separated 5 minutes to 30 minutes after shaking ○: Separated 30 minutes to 60 minutes after shaking ◎: Separated 60 minutes or more after shaking Aerosol types can be used for various purposes by adding medicinal or active ingredients depending on the purpose, such as insecticides, various cleaners, hair sprays, paints, etc.
Examples include deodorants, antiperspirants, air fresheners, and cosmetics.

Next, typical examples of the present invention will be shown.

In the examples, % indicates weight %, and parts indicate parts by weight.

Example 1 Air freshener stock fragrance 1.0% Triethylene glycol 4.0% Ethanol 50.0 Hydrogenated castor oil Ethylene oxide addition 0.3 (P≒25) Ion exchange water Balance 100
．． 0 A mixture of geraniol, citronellol, linalool, linalyl acetate, and phenylethyl alcohol was used as the fragrance.

Triethylene glycol is also an air purifier that traps dust and cigarette smoke.

The iodine value of the hydrogenated castor oil oxidized ethylene adduct used in this example and the above experimental examples is 0.9.

An air freshener was obtained by filling an aerosol can with 65 parts of the stock solution and 35 parts of LPG as a propellant.

Example 2 Glass cleaner aerosol stock solution % pholyoxyethylene nonyl phenyl 0.1 ether (P≒9
) Polyoxyethylene sorbitan oleate 0.1 ate (P≒20) Ethyl alcohol 30.0 Castor oil oxidized ethylene adduct (P≒ o.1100) Ion exchange water Balance 100.
0 Polyoxyethylene nonyl phenyl ether and polyoxyethylene sorbitan oleate are cleaning agents (cleaning ingredients)
It is.

A glass cleaner aerosol was obtained in the same manner using 15 parts of LPG as a propellant to 85 parts of the stock solution.

When the emulsification state of the aerosol compositions of Examples 1 and 2 was examined, good and stable emulsification states could be obtained in both cases.

That is, when these aerosol compositions were subjected to a storage test at 50° C., they did not separate even after 20 days.

Claims (1)

[Claims] 1 Consists of a stock solution containing an active ingredient or medicinal ingredient and a propellant, and the mixing ratio of the stock solution and propellant is 95/5 to 2 by weight.
0/80, the stock solution is an aerosol composition consisting of a liquid in which an active ingredient and/or a medicinal ingredient is dissolved or dispersed in an aqueous solution of an alcohol having 3 or less carbon atoms and containing 20 to 80% by weight of alcohol, compared to the stock solution. An aerosol composition characterized in that castor oil or an ethylene oxide adduct of hydrogenated castor oil having an average added mole number of ethylene oxide of 25 to 150 is blended as an emulsifier.