JPS5838408B2 - Composition of dental cement - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a composition of zinc white eugenol cement (hereinafter abbreviated as ZOE) formulated with calcium hydroxide.

Dental cement, which uses the reaction and hardening of zinc white and eugenol (also called eugenol, used synonymously with butterfly oil), has been used in dental treatment for a long time, and has a wide range of clinical applications. It is extremely widespread, and a large number of products have been put into practical use by making various improvements to formulations and manufacturing methods.

ZOE is a so-called two-component cement consisting of part A (based on zinc white) and part B (based on eugenol); part A is powder, and part B is liquid (hereinafter referred to as If part A is a paste, part B is often a paste (hereinafter abbreviated as tube type).

When using, the dentist takes an appropriate amount of each of Agents A and B, kneads them with a spatula, and applies them to the affected area either as a slurry or as a putty after allowing the hardening reaction to proceed and lose fluidity. .

After some time (depending on the application, it usually takes from a few minutes to about 30 minutes), the curing reaction is completed and solidified (the solidified ZOE is hereinafter abbreviated as cement).

The approximate composition of ZOE in the prior art is as follows.

In each case, the prescribed amount (W/W%; the same applies hereinafter) varies depending on the use, so it is shown as a "range."

A basic outline of the manufacturing method will also be described.

(1) Prescription example of powder-liquid ZOE (compounding ratio when used: 1220.31 in A2B) Agent A Zinc Huakou Jin Others* 30-80 20-50 0-20 (sub)* Contrast agent, Filler, rarely calcium hydroxide, etc. B agent made by blending a certain amount of each and sieving after crushing in a crusher Eugenol olive oil and others * 50-80 10-20 O-10 (to) * Contrast agent, (2) Tube-type ZOE (mixture ratio A: 11 in B when used)
: 1.5? ) Agent A zinc white olive oil and others* 3 O~80 20~50 0~10 (To)* Contrast agent, filler, etc.; Add zinc white to olive oil and knead it, and then add other (contrast agent, filler, etc.) ) B agent eugenol rosin and others * 20-50 2 O-70 (support) * Contrast agent, filler, etc.; Eugenol is heated to 70-1200, and rosin, When adding calcium hydroxide to the above formulations (1) and (2), which are prepared by adding other ingredients (contrast agent, filler), stirring and dissolving, and filtration with heat, calcium hydroxide is Since it is a powder, it cannot be used in formulation (1) as agent B, and furthermore, it reacts with eugenol when heated, so it cannot be used in formulation (2) as agent B.

However, there is no essential difference between the prior art and the present invention in terms of formulating calcium hydroxide to agent A.

Next, in order to understand the present invention, the application of calcium hydroxide to dental treatment will be explained.

There are two reasons for treating ZOE with calcium hydroxide: to expect a medicinal effect, and to give cement special (discussed later: characteristic of cement containing calcium hydroxide) physical properties. It is in.

In the former case, it is necessary to use calcium hydroxide in as high a concentration as possible, that is, it is necessary to have high calcium ions in the area where it is applied, and it is said that it is better to increase the alkalinity of the area.

The purpose of treatment is root canal filling. Root canal filling is a dental surgery in which an artificial substance is filled in place of the removed pulp nerve.
There are high hopes for the practical application of Shichiment, which contains a high concentration of calcium hydroxide, as an ideal filler.

In the latter case, it is then used for temporary sealing or gingival dressing purposes.

The temporary sealant is an artificially drilled hole in the tooth (cave).
A gingival dressing is a temporary filling (usually within 7 days) used to cover the area after a gingivectomy.

A gum bandage is also left in the mouth for 7 to 10 days.

Therefore, the purpose of the present invention is to obtain improved root canal filling agents, temporary sealants, gingival dressings, and similar products thereof by adding calcium hydroxide at a high concentration, and the effects of the present invention are to achieve this purpose. It is played along with.

When applying temporary seals or gingival bandages, it is necessary for the ZOE to go through a semi-solid state similar to putty before it hardens, and furthermore, it is better for the putty-like ZOE to not stick to fingers or treatment instruments with stickiness. For use, the putty-like ZOE is preferably shaped into an appropriate size and applied to the affected area, losing its plasticity after several minutes (2 to 10 minutes) and remaining in the affected area.

In addition, the cement for this purpose is required to be not brittle and have slight flexibility and toughness, but in addition to this, it must not be putty-like or sticky.5ZOE has not been completed until today despite numerous studies. has not yet been achieved.

Furthermore, in the case of conventional gum dressings, asbestos powder is added to bind the cement to improve toughness. is required to be removed.

However, asbestos powder has a smaller bulk than other inorganic fiber powders (synthetic silica fibers, glass fibers, etc.), natural fibers (cotton, wool, etc.), or synthetic fibers (nylon, polyester, etc.), and is less compatible with cement. Because of its good quality, it has no choice but to be used to this day.

According to research by the present inventors, when cement contains 10% or more of calcium hydroxide and is supplemented with other ingredients, the above-mentioned "putty-like" and "non-sticky" properties are achieved in cement. may be granted.

This characteristic property was specific to ZOE when calcium hydroxide was formulated and could not be replaced by any other compound.

Furthermore, it is truly revolutionary that we succeeded in using pieces of nylon thread (described later) in place of asbestos because of its 1". putty form.

When calcium hydroxide is prescribed to powder-liquid ZOE, since calcium hydroxide is hygroscopic and absorbs carbon dioxide gas,
It changes orally and the concentration of calcium hydroxide decreases.

This not only has a negative impact on the therapeutic effect, but also significantly changes the curing time of the product during use.
This poses a serious hindrance to the surgeon's smooth treatment operations.

However, if the prescribed amount of calcium hydroxide is small (that is, it is diluted with other precepts), the cap is tightly closed after use, and the use is finished as soon as possible, up to 15% calcium hydroxide in Form A can be used. The formulation can be commercialized as a practical technical limit.

However, from the viewpoint of therapeutic effects, it is natural that ZOE formulated at a higher concentration is desired, considering its application to the root filler mentioned above.

Next, in the case of the tube type A agent, in order to produce the tube type A agent, it is necessary to go through a step of kneading each component.

In this process, the ingredients zinc white, calcium hydroxide, and olive oil are mechanically kneaded and come into contact with each other, and the adhering water of each ingredient, especially calcium hydroxide, is kneaded, and the water in the air and It is not hard to imagine that carbon dioxide gas etc. may be mixed in.

The thus prepared agent A is filled into tubes (depending on the performance of the filling machine, the operating efficiency of the filling machine may be increased by heating it to 50 to 100°C during this process), but heating operations are not required during the filling process. Even if it is not accompanied by , it will gradually change in quality after being filled and will solidify if stored at room temperature for several months.

The higher the content of calcium hydroxide, the faster the deterioration.According to the data of the present inventors (described later), agent A containing 40% calcium hydroxide lasts for 50 days at room temperature from March to May. It solidified to the point that it was unusable.

As a result of intensive research into manufacturing ZOE (formula A), which is a pre-formulated form of calcium hydroxide that does not deteriorate during storage, the present inventors have found that they have found that formulation A has extremely excellent storage stability, and that it is easy to manufacture using conventional methods. The present invention has been completed by creating a ZOE that allows the device to be used as is and the treatment methods that have been accumulated over many years to be used without any changes.

According to the present invention, the oil component in Part A (vegetable oil in the prior art) is silicone oil, to which fine powder of calcium hydroxide is gradually added and kneaded evenly, and then zinc white is gradually added to it. Knead further while adding.

As a result, the incompatibility with moisture, which is a characteristic of silicone oil, is effectively exhibited, preventing calcium hydroxide from absorbing moisture and carbon dioxide gas during manufacturing operations, and preventing subsequent deterioration.

Fine particles of silicon oxide and calcium sulfate can also be added as other additive components to Part A.

In order to more effectively use agent A according to the present invention for treatment, B
The role of agents is also important.

That is, when the ZOE according to the present invention is applied for the purpose of root canal filling, agent B may be a suitable contrast agent (for example, barium sulfate).
If the purpose is temporary sealing or gingival dressing, citric acid or tartaric acid may be prescribed to neutralize the alkalinity of the cement based on calcium hydroxide, and further improve the toughness of the cement. For this reason, a small amount of extremely fine short nylon thread is sometimes added (see Patent Application No. 79749 filed by the same applicant and Japanese Patent Application Laid-Open No. 1983-36193).

Example I Agent A: Zinc white 31' Calcium hydroxide 40f! silicone oil (
KF56) 31' B agent: Eugenol 262 Rosin 3og barium sulfate 40S' Keisouji
4y Production method: Calcium hydroxide (preliminarily sieved through a 100-mesh sieve) is added to silicone oil and kneaded, a small amount of zinc white is added to the mixture, kneaded into a paste, and the mixture is divided into tubes to form part A.

Separately, add rosin to Eugenol heated to 100°C in an oil bath, stir to dissolve, cool to 80°C, filter through 80 mesh, add barium sulfate and diatomaceous earth, mix well, Divide into portions and use as agent B.

Before use, take equal amounts of Part A and Part B, mix well, and use in the same manner as conventional ZOE root canal filling agents.

Example 2 Agent A: Zinc white 50S'calcium hydroxide 30S'liquid paraffin
5fI silicone oil (KF56) 15
fIB agent: Eugenol 322 Rosin 47f? Quekadori
10y diatomaceous earth 8′? Nylon thread (
1.5 d, 1 min) 31 Manufacturing method: Mix liquid paraffin with silicone oil, add calcium hydroxide (100 mesh sieve) and knead.

For agent B, dissolve rosin in eugenol in the same manner as in Example 1, filter it, add 80-mesh pulverized citric acid, then diatomaceous earth, add nylon thread, mix homogeneously, and pour into a small tube. It was made separately.

Before use, take equal amounts of Part A and Part B, mix well, and use the conventional Z
Use in the same way as OE temporary sealant.

Example 3 Part A: Zinc white 40f Calcium hydroxide 30f Silicone oil 15g (KF56) Silicone oil (KF96300CS) "" Part B: Same manufacturing method as Example 2: Two types of silicone oils were mixed, and the following is an example. Operate in the same way as 2.

At the time of use, take equal amounts of Part A and Part B, mix well, and use in the same manner as a conventional gingival dressing.

The oral stability of Formulation A according to the present invention was confirmed through experiments.

This is shown in Table 1. Storage conditions in this experiment (50
℃) was confirmed to reproduce chemical changes at room temperature.

Also, the change in temperature at 50°C for 3 days corresponded to a change in room temperature over approximately 2 months.

During the experiment, a sample (A agent) was packed into a 10 TrLl tin tube and stored in an air bath at 50±1° C., and changes in the contents of the tube were visually examined every 24 hours.

Claims (1)

[Scope of Claims] 1. In a two-component dental zinc white eugenol cement consisting of an artificial agent (based on zinc white) and an agent B (based on eugenol), the A and B agents are each made into a paste. (1) Part A consists of the main ingredient (zinc white) and calcium hydroxide mixed together with silicone oil, and other subcomponents are added. (2) Part B consists of the main ingredient (zinc white) and calcium hydroxide. Eugenol) and rosin, as well as nylon fiber, citric acid or tartaric acid, either alone or in combination, or without addition, and with other subcomponents added, and is the same as the above A agent. A dental cement composition comprising Agent B.