JPS5840925B2 - toothpaste composition - Google Patents

Description

Detailed Description of the Invention The present invention uses calcium sulfate as an abrasive, and an anionic activator and a polyoxyethylene/polyoxypropylene block copolymer type nonionic activator (hereinafter referred to as "Pluronic activator") as a foaming agent. to be called.

). Conventionally, it has been known to use calcium sulfate as an abrasive for tooth brushing, but since calcium sulfate has a higher solubility in water than general abrasives for tooth brushing such as calcium phosphate, calcium sulfate is simply used as it is during tooth brushing. When blended, there is a problem in that the eluted calcium ions act on the surfactant blended as a foaming agent, forming a sparingly soluble salt and reducing the foaming properties of the toothpaste.

In addition, when calcium sulfate is used as an abrasive, compared to other general abrasives such as calcium phosphate and calcium carbonate, it gives a strong astringency or irritation to the oral cavity, has a poor juice effect, and has the problem of reducing the feeling of use. be.

In addition, it has been known to use an anionic activator and a nonionic activator in combination as a foaming agent for toothpaste, but a pluronic activator is used as a nonionic activator, and an anionic activator and a pluronic activator are combined in toothpaste. There are almost no examples of it being blended with US Patent No. 2773801
No. 1, only the combination of an anionic activator and a pluronic type activator is proposed.

This is because Pluronic-type activators have low foaming properties and antifoaming properties, and in fact, anionic activators and Pluronic-type activators are used in toothpastes that use dicalcium phosphate dihydrate or aluminum hydroxide as abrasives. It has been found that the higher the ratio of Pluronic type activator to anionic activator is, the lower the foaming power is when blended with Pluronic type activator. At present, it has not been put to practical use as a drug.

In view of the above circumstances, the present inventors conducted intensive research to obtain a calcium sulfate-based toothpaste with high foaming power and excellent usability. When combined with a Pluronic type active agent in a specific ratio, that is, in a weight ratio of 6:4 to 3, the foaming power increases, astringency is eliminated, the juice effect is improved, and the feeling of use is improved. We found that the results were significantly improved.

Such a synergistic effect is not seen when dibasic calcium phosphate or aluminum hydroxide is used alone as an abrasive, but is a specific effect seen when calcium sulfate is blended. This is a specific effect seen when used in combination with a pluronic type active agent at a ratio within the above range.

Therefore, a calcium sulfate-based toothpaste that uses an anionic activator and a pluronic-type activator in the above ratio increases the foaming power, improves the feeling of use, and effectively uses calcium sulfate as an abrasive. The present inventors have discovered that the Pluronic active agent can be effectively used as a foaming agent for tooth brushing, and the present invention has been completed.

That is, in the present invention, calcium sulfate is blended as an abrasive, and the anionic activator and pluronic type activator (polyoxyethylene/polyoxypropylene block copolymer type nonionic activator) are mixed in a weight ratio of 6:4 to 3. The present invention provides a dentifrice composition characterized in that it is used in combination at a ratio of:

The present invention will be explained in detail below.

The calcium sulfate used in the present invention is mainly a dihydrate, but any other calcium sulfate that can be used as an abrasive for toothpaste can be used.

As an abrasive, in addition to calcium sulfate, other general abrasives for toothpaste, such as dibasic calcium phosphate.
Hydrates and anhydrides, calcium carbonate, silicic anhydride, aluminum hydroxide, calcium pyrophosphate, insoluble sodium metaphosphate, etc. may be blended.

In this case, the total amount of these abrasives is usually 30 to 60%.
(wt%, same below).

The anionic activator used in the present invention may be any general anionic activator for tooth brushing, such as water-soluble salts of higher alkyl sulfates such as sodium lauryl sulfate, sodium dodecylbenzenesulfonate, etc. Alkylaryl sulfonates, water-soluble salts of higher fatty acid monoglyceride monosulfates such as hydrogenated coconut fatty acid monoglyceride sodium monosulfate, alkyl sulfoacetates such as sodium lauryl sulfoacetate,
One or more types of higher saturated aliphatic acylamides of lower aliphatic aminocarboxylic acids such as sodium N-lauroyl sarcosinate are used.

Pluronic type activators (polyoxyethylene/polyoxypropylene block copolymer type non-ion activators) are represented by the following general formula (1) (% formula %) (1), have an average molecular weight of 8000 to 9000, and have an Average molecular weight of propylene glycol moiety: 1700~
1800. It is preferable to use ethylene oxide containing 80 to 90% by weight of ethylene oxide in the total molecule, and for example, one commercially available from Sanyo Kasei Corporation as Newpol PE-68 is used.

The ratio of the anionic activator and the pluronic type activator used in combination is 6:4 to 3 in terms of weight ratio.

If the proportion of the pluronic type active agent is at least or more than this range, the foaming properties and foam stability of the toothpaste will deteriorate, and the object of the present invention cannot be achieved.

In addition, the total amount of anionic active agent and pluronic type active agent is 0.5% of the total from the viewpoint of foaming property and stability of toothpaste.
It is preferably 10% to 10%, particularly 1 to 5%.

Furthermore, in the present invention, in addition to the above-mentioned components, neutral or alkaline water-soluble phosphates, i.e., secondary phosphates such as disodium hydrogen phosphate, tertiary phosphates such as trisodium phosphate, Pyrophosphate salts such as sodium pyrophosphate,
One or more types of tripolyphosphate salts such as sodium tripolyphosphate and monofluorophosphate salts such as sodium monofluorophosphate can be blended, and by blending these phosphates, the feeling of use of toothpaste, It is possible to further improve foaming power without impairing stability.

In this case, the amount of the water-soluble phosphate is 0.1 to
The content is preferably 5%, particularly 0.3 to 1%, and good effects can be obtained in this range.

The other components of the toothpaste composition according to the present invention are the same as in the case of ordinary toothpaste, and when manufacturing toothpaste,
As a binder, carboxymethyl cellulose, carrageenan, alginic acid, propylene glycol alginate, guar gum, hydroxyethyl cellulose, xanthan gum, etc. are usually blended in an amount of 0.3 to 10% (in this case, hydroxyethyl cellulose or xanthan gum should be used especially from the viewpoint of liquid separation). is preferred.

), and as humectants, glycerin, sorbitol, propylene glycol, polyethylene glycol, etc. are usually used.
In addition to the 5-35% blend, flavorings such as peppermint and spearmint, sweeteners such as saccharin, fluorine compounds, antibacterial agents, anti-enzyme agents, other active ingredients, preservatives, etc. are added as necessary. The required toothpaste is manufactured by this process.

Therefore, the dentifrice composition according to the present invention contains calcium sulfate as an abrasive, and also uses an anionic activator and a pluronic type activator in a weight ratio of 6:4 to 3. The synergistic effect increases the foaming power and provides a sufficient oral cleaning effect.

In addition, it has the characteristics that it has no astringency, has an improved juice effect, and has a feeling of use that is equal to or better than that of conventional toothpaste, and therefore can be used suitably.

Next, an experimental example will be shown to further specifically explain the present invention*.

Experimental Example 1 Using a conventional method, the total amount of blowing agent was adjusted to i, o%, and sodium lauryl sulfate (SDS) was used as the blowing agent, and Pluronic activator (Newpol PE-68 manufactured by Sanyo Chemical Co., Ltd.) was used.
Toothpastes with the following formulations were manufactured using the following combinations in various proportions.

Calcium sulfate dihydrate 45.0% by weight Carboxymethyl cellulose 1.0 Glycerin
20.0 // sweetener
o, 1〃Silicon dioxide
1.5 Fragrance 1.0 Foaming agent 1. O〃Water
Remaining 100.0% by weight Next, this toothpaste 51 was collected in a Nessler tube 1007711, and after adding 30ml of distilled water, it was shaken 40 times at a speed of 1 time/second, and the amount of foam after 1 minute was calculated. Measured at room temperature.

The results are shown in Figure 1. In addition, the foam volume after 5 minutes was measured at room temperature in the same manner as above, and the results are shown in Table 1 and FIG.

In FIG. 1, ■ indicates the foam height after 1 minute, and ■ indicates the foam height after 5 minutes.

Furthermore, in the above formulation, toothpastes were manufactured in which the amount of sodium lauryl sulfate was fixed at 1.0% and the amount of Pluronic active agent was varied. was measured.

The results are shown in Figure 2.

In Fig. 2, ■ indicates the foam height after 1 minute, and ■ indicates the foam height after 5 minutes.

Therefore, from FIG. 1 and FIG. 2, it is found that there is a synergistic effect when an anionic activator and a pluronic type activator are used in combination, and the blending ratio of an anionic activator and a pluronic type activator is determined by the foaming power and foam stability. From the viewpoint of sex, the weight ratio is 6:
It has been found that a range of 4 to 3 near gives excellent results.

For comparison, a toothpaste with the same formulation as above using dibasic calcium phosphate dihydrate as an abrasive instead of calcium sulfate dihydrate (foaming agents include sodium lauryl sulfate and pluronic active agent). Nupol PE was used in various proportions.

However, the total amount of blowing agent was 1.0%. ), and its foaming power was similarly measured by the shaking method, and the results shown in FIG. 3 were obtained.

Note that the results are the amount of foam after 1 minute.

As is clear from the above results, toothpaste using dibasic calcium phosphate as an abrasive has an antifoaming property of the Pluronic active agent. In contrast, toothpaste with calcium sulfate as an abrasive has an anionic activator (
When using sodium lauryl sulfate (*sodium lauryl sulfate*) and a pluronic activator together at a weight ratio of 6:4 to 3, the foaming power decreases despite the combination of the pluronic activator, which has antifoaming properties. increased, and a synergistic effect was observed due to the combined use of an anionic activator and a pluronic activator.

Experimental Example 2 In the toothpaste formulation shown in Experimental Example 1, a mixture of sodium α-olefin sulfonate, sodium N-lauroyl sarcosinate, and sodium lauryl sulfate was used as an anionic activator (mixing ratio was 1:1 by weight). Toothpastes with a total foaming agent content of 1.0% were produced using hydrogenated coconut fatty acid monoglyceride sodium monosulfate and each of these and the Pluronic active agent Newpol PE-68 in various proportions.

In the same manner as in Experimental Example 1, this toothpaste 51 was collected in a 100ml Nessler tube, and 3071L of distilled water was added thereto.
The mixture was shaken 40 times at a speed of 1 minute per second, and the amount of foam was measured at room temperature after 1 minute.

The results are shown in Table 2. The results in Table 2 also show that the amount of foaming increases when an anionic activator and a pluronic activator are used together at a weight ratio of 6:4 to 3.

Experimental Example 3 In the toothpaste formulation shown in Experimental Example 1, the blending ratio of sodium lauryl sulfate and pluronic active agent was set to 1:1 by weight, and toothpastes were produced in which the total amount of foaming agent was varied,
The foaming power (the amount of foam after 1 minute) was measured by the shaking method in the same manner as in Experimental Example 1.

The results are shown in Figure 4.

Although no further increase in foaming power was observed when the foaming agent was added at 4% or more, it was found that adding 10% or more of the foaming agent had an adverse effect on the stability of the dentifrice system. Therefore, from the above results, it was found that the total amount of blowing agents is preferably in the range of 0.5 to 10%.

Experimental Example 4 Toothpastes having the formulation shown in Experimental Example 1 were further blended with the phosphates shown in Table 3, and their foaming power was evaluated by a shaking method.

The total amount of foaming* agent was 2%, and the blending ratio of sodium lauryl sulfate and Pluronic active agent was 1:1 (weight ratio).

The results of foaming power evaluation are also listed in Table 3. From the results shown in Table 3, neutral or alkaline water-soluble phosphates (disodium hydrogen phosphate, trisodium phosphate, trisodium phosphate,
It was found that the foaming power was further increased by adding potassium, sodium pyrophosphate, sodium monofluorophosphate, etc.).

Experimental Example 5 In the toothpaste formulation shown in Experimental Example 1, dibasic calcium phosphate dihydrate or calcium sulfate dihydrate was used as the abrasive.
Using a hydrate, the total amount of blowing agent is 1.5%, and when sodium lauryl sulfate (SDS) and Pluronic active agent are used together, the mixing ratio is 1:1 (weight ratio). Toothpastes were produced, and their sensory values (astringency, amount of foaming, juice effect, feeling of use) were evaluated using the 5cheff'e paired comparison method, and the results shown in Table 5 were obtained.

In addition, the juice effect can be obtained by drinking juice before brushing your teeth.
Memorize the taste, then brush your teeth with the prescribed toothpaste, drink the first juice, memorize the taste, and after 2-3 hours, brush your teeth again with another toothpaste and drink the juice. This was done by drinking it and evaluating the difference in taste from the first bottle.

From the above results, the toothpaste that combined calcium sulfate and an anion activator (sodium lauryl sulfate) had significantly inferior foaming properties and had a poor feel when used, but the toothpaste that used calcium sulfate as an abrasive When an anionic active agent and a pluronic active agent are used together as a foaming agent, the foaming property is improved, and the feeling of use and juice effect are better than that of the conventional toothpaste that combines dibasic calcium phosphate and an anionic active agent. In addition, by incorporating water-soluble phosphate, it has almost no effect on the feeling of use or the juice effect.
It has been found that the foaming property can be increased more than that of conventional dibasic calcium phosphate toothpastes, and therefore, it has been recognized that the toothpaste according to the present invention can be suitably used.

Examples are shown below.

Example 1 A toothpaste composition having the following formulation was produced by a conventional method.

Calcium sulfate dihydrate 50.0% by weight Hydroxyethylcellulose 1,2 Sorbitol
25.0 “Colloidal Silica
1.5 Fragrance saccharindium monoglyceryl sulfate monopluronic active agent (PE-68) Water 1.0% by weight Oll 〃 ■, O 〃 1.2 71 Fungsu 100.0% by weight Example 2 Conventional method A line drawing composition having the following formulation was produced.

Calcium sulfate dihydrate xanthan gum glycerin colloidal silica fragrance saccharin sodium lauryl sulfate 48.0% by weight 1.0〃 20.0 // 1.5〃 1.0〃 0.1〃 0.75 〃 Pluronic active agent (PE -68) 0.75% by weight Disodium hydrogen phosphate, 1.0 water balance 100.0% by weight Example 3 A toothpaste composition having the following formulation was produced by a conventional method.

■Type anhydrous calcium sulfate 10.0% by weight 2nd
Calcium phosphate dihydrate 35.0 // Colloidal silica 1.5 Rubitol 22.0 // Carboxymethylcellulose 0.7 Carrageenan
0.3 Fragrance 1.0 Saccharin 0.1 α-olefin sulfonic acid 1.2 Thorium Pluronic activator (PE 1.0 //
-63) Sodium monofluorophosphate 0.76 //mu water balance 100.0% by weight Example 4 A toothpaste composition having the following formulation was produced by a conventional method.

Calcium sulfate dihydrate Sorbitol silicate Glycerin Anhydrous Propylene glycol Alginate Flavor Saccharin Sodium lauryl sulfate Sodium N-lauroyl sarcosinate 45.0% by weight 1.0 10.0 // 10.0 // 1.2 ■、0〃 0.1〃 0.8〃 0.2〃 Pluronic active agent (pE-1,01/68) Water Balance 100
．． 0% by weight All of the toothpastes of Examples 1 to 4 had high foaming power and an excellent feeling of use.

[Brief explanation of drawings]

Figures 1 and 2 are graphs showing the foaming power when the combined ratio of sodium lauryl sulfate and pluronic active agent is changed in toothpastes containing calcium sulfate dihydrate as an abrasive, respectively. Figure 3 shows dibasic calcium phosphate.
A graph showing the foaming power when the combination ratio of sodium lauryl sulfate and pluronic active agent is changed in toothpaste that uses dihydrate as an abrasive. Figure 4 shows the foaming power of toothpaste that uses dihydrate as an abrasive. 2 is a graph showing the foaming power when the total amount of sodium lauryl sulfate and Pluronic active agent is changed in the toothpaste used as the agent.

Claims (1)

[Claims] 1 Calcium sulfate is blended as an abrasive, and an anionic activator and a polyoxyethylene/polyoxypropylene block copolymer type nonionic activator are mixed as a foaming agent in a weight ratio of 6:4 to 3. A dentifrice composition characterized in that they are used together in a proportion. 2. The dentifrice composition according to claim 1, wherein the total amount of foaming agents is 0.5 to 10% by weight. 3 Calcium sulfate is blended as an abrasive, and an anionic activator and a polyoxyethylene/polyoxypropylene block copolymer type nonionic activator are used together as a foaming agent at a weight ratio of 6:4 to 3, and Neutral or alkaline water-soluble phosphate should be added to the total amount of 0.1 to 5
A dentifrice composition characterized in that it has an increased weight percentage. 4. The dentifrice composition according to claim 3, wherein the water-soluble phosphate is a secondary phosphate, a tertiary phosphate, a pyrophosphate, a tripolyphosphate, or a monofluorophosphate. 5. The dentifrice composition according to claim 3 or 4, wherein the total amount of foaming agents is 0.5 to 10% by weight of the total amount.