JPS5842845B2 - honey bee - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a composition capable of preventing American rot in honeybees.

What is American rot? Gram-positive bacterium Bacillus
It is a bacterial disease caused by P. rvae.

This disease is extremely contagious, and as it is a legally contagious disease, if symptoms are confirmed, it is mandatory to immediately incinerate beekeepers, so the damage it causes to beekeepers is comparable to dogs.

As a result of intensive research on this American rot disease, the present inventor discovered that the causative agent of this disease, Bacillus 1arvae.
6-medoxy 4-pyrimidinylsulfanilamide (hereinafter abbreviated as sulfamonomethoxine).

) and 2,6-cymethoxy4-pyrimidinylsulfanilamide (hereinafter abbreviated as sulfadimethoxine).

) was found to have an antibacterial effect several times stronger than other sulfa drugs, and it was confirmed that this disease could be completely controlled by administering the above drug, and that no pathogenic bacteria was detected even after administration, and the present invention was developed. completed.

The present invention will be explained in more detail.

The basic dosage method is 200 to 50% sulfamonomethoxine sodium or sulfadimethoxine sodium per liter of aqueous solution such as water, sugar, honey, etc.
Dissolve 00 mg and feed from 1 to 100 mg per week using a feeder.
The drug is administered twice, either continuously or intermittently every week.

Also, administer the drug in the same manner as above by directly applying or spraying it on the surface of the nest tiles using a sprayer.

Furthermore, even if the drug is administered according to the above-mentioned method, it will not have any adverse effect on bees, and almost no drug will remain in the honey, so it will not cause any problems in terms of public health.

Below are Bacillus larv of sulfamonomethoxine sodium and sulfadimethoxine sodium.
The antibacterial activity against A. ae and examples of prevention of American rot disease will be described.

Reference Example 1 Comparison of the antibacterial activity of sulfa drugs against the causative bacteria B and 1arvae of American rot disease Example 1 When the drug was administered using a feeder.

Experimental conditions (1) Number of test bee colonies 1 district 5 targeting bee farms where the disease always occurs every year A total of 300 groups were tested.

(2) Experimental period: Group 0*' September 1970 - March 1970 (3) Experimental method A fixed amount of each drug was dissolved in sugar solution (1 kg of sugar in 1 ton of warm water) and placed in a feeder for one week. 2 doses were given at a time, and the administration was continued for 5 weeks.

Confirmation of rot 22 weeks after completion of medication and B, 1a
I searched for rvae.

Example 2 When spraying chemicals on nest tiles Experimental conditions (1) Number of test bee colonies A total of 150 groups were tested, with 30 groups per section.

(2) Experiment period January 1970 - April 1970 (3) Experiment method Dissolve a certain amount of each drug in water and use a sprayer to spray it on the nest tiles twice a week for 5 consecutive weeks. Administered by spray.

Confirmation of rot 18 weeks after completion of medication and B, 1ar
I searched for vae.

From the above test results, sulfamonomethoxine and sulfadimethoxine are the pathogens of American rot disease B, 1.
It was found that it has extremely strong antibacterial activity against S. arvae and also has a clear preventive effect on rot disease in vivo.

Claims (1)

[Claims] 1. A prophylactic agent for American rot in honeybees, which comprises 16-medoxy 4-pyrimidinyl sulfanilamide or 2,6-cymethoxy 4-pyrimidinyl sulfanilamide as an active ingredient.