JPS5927324B2 - Gargle composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a clarifier composition, and more particularly to a clarifier composition stably containing azulene.

Azulene is a component of chamomile flower decoction, which has a dark blue color and has been said to have anti-inflammatory, tissue regenerating, and anti-allergic effects since ancient times, and is widely used in cosmetics and pharmaceuticals, and is also included in laxatives.

However, azulene is inherently unstable to light and heat, and when it begins to decompose due to light and heat, its deep blue color gradually disappears, and in proportion to this, azulene's anti-inflammatory, tissue regenerating, and anti-inflammatory effects Allergic effects are also reduced.

Especially in an aqueous solution system such as a clarifier, azulene has poor light resistance and heat resistance, and it is extremely difficult to mix azulene stably for a long period of time in an aqueous solution system, that is, to maintain the dark blue color of azulene for a long period of time. It is difficult to

While researching the stability of azulene in a destaining agent containing azulene, the inventor found that the light resistance and heat resistance of azulene were significantly improved when azulene and chlorhexidine salt, which is known as a bactericidal agent, coexisted. This led to the completion of the present invention.

Therefore, in the present invention, azulene has a ratio of 0.01 to 0.1 (the same applies below the weight ratio), and chlorhexidine salt has a ratio of 0.03 to 0.1.
20-50% of ethanol and polyoxyethylene hydrogenated castor oil (average number of moles of ethylene oxide added,
The present invention provides a clarifying agent composition containing 1 to 2 chlorides (the same applies hereinafter), and the decomposition of azulene due to light and heat is suppressed, and the deep blue color of azulene is maintained for a long time. Retained for a period of time.

Table 1 below shows the results of testing the effects of various chemicals on the light resistance and heat resistance of azulene in azulene-containing stimulants.

The test was carried out by filling a colorless transparent glass container with a clarifier having the composition shown below, and visually determining the change in the deep blue color of azulene in a light resistance test by exposure to sunlight and a heat resistance test by constant temperature storage at 55°C.

Composition Azulene 0.02 drug
0.05 Sodium saccharin 0.05 Ethanol 25.00 Glycerin 5.00 Polyoxyethylene hydrogenated castor oil 1.25 Fragrance
1.00 Purified water Adjust to 100%
As a control, a clarifier containing no drug was used.

The results are shown below. ○: No dark blue change of azulene ×: Fading of deep blue color of azulene As is clear from Table 1, only chlorhexidine salt specifically improves the light resistance and heat resistance of azulene.

The following Tables 2 to 4 show destaining agents (with the same composition as above) containing azulene and chlorhexidine gluconate (
The results of testing the change in azulene over time in the heat resistance test and rice and light resistance test of sample composition) are shown.

In both results, the initial amount of azulene is taken as a factor of 100,
It is shown as the azulene residual rate (correspondence) calculated from the change in absorbance at 570 mμ over time, and a throat mouthwash containing no chlorhexidine gluconate was used as a control composition.

It is clear from Table 2 that the composition containing chlorhexidine gluconate suppresses the decomposition of azulene even during long-term high-temperature storage.

As is clear from Tables 3 and 4, compared to the control composition, the composition containing chlorhexidine gluconate
The light resistance of azulene is significantly improved, and especially when it is placed in a paper case, azulene can be prevented from being decomposed by light.

Examples of the chlorhexidine salt to be used include chlorhexidine gluconate and chlorhexidine hydrochloride, which are added in an amount of 0.03 to 0.1 to the composition.

Although it is possible to incorporate a larger amount, it is rather disadvantageous from an economical point of view.

The following Table 5 shows the residual rate (%) of azulene after 7 days of sunlight exposure and 1 month at 55°C using a destaining agent with the same composition as above but with various amounts of chlorhexidine gluconate.
The results are shown below.

The residual rate of azulene was measured in the same manner as in Tables 2 to 4.

As is clear from Table 5, a dose of chlorhexidine gluconate in the range of 0.03 to 0.1 is sufficient.

The dosage of azulene may be the same as that normally contained in the rinsing agent composition, and is added in a ratio of 0.01 to 0.1.

The throat preparation composition of the present invention can be manufactured according to conventional methods.

Next, the present invention will be explained in more detail with reference to Examples.

Example 1 Composition Chlorhexidine gluconate 0.05 azulay 0.02 saccharin sodium 0.05 ethanol
25.00 Glycerin
5.00 Polyoxyethylene hydrogenated castor oil 2.00 Fragrance 1.0
0 Purified water Adjusted to 100% Add polyoxyethylene hydrogenated castor oil, chlorhexidine glyconate, azulene, and fragrance to ethanol and stir. Add glycerin to this and mix uniformly to obtain a scolding agent.

Example 2 Composition Chlorhexidine criconate 0.01 Azulene 0.005 Saccharin sodium.

, o5 ethanol 30.0
0 Propylene glycol 5.00 Polyoxyethylene hardened castor? 'E13 2.0
0 Fragrance 1.00 Purified water Adjusted to 100% A clarifier was obtained in the same manner as in Example 1 above.

Example 3 Composition Chlorhexidine hydrochloride 0.10 Azulene 0.10 Saccharin sodium 0.05 Ethanol
50.00 Glycerin
3.o.

Sorbitol 2.00 Glopylene Glycol 1.00 Polyoxyethylene Hydrogenated Castor Oil 1.50 Fragrance
1.00 Purified water Adjusted to Ioo to obtain a phlegm-containing agent in the same manner as in Example 1 above.

Example 4 Composition Chlorhexidine gluconate 0.01 Azulene 0.05 Saccharin sodium.

, o5 ethanol 20.0
0 Glycerin 2.00.1 Sorbitol 3.00 Polyoxyethylene hydrogenated castor oil 2.00 Fragrance
1.00 Purified water Adjusted to 100% to obtain a phlegm-containing agent in the same manner as in Example 1 above.

4 Example 5 Composition Chlorhexidine hydrochloride 1.00 Azulene 0.02 Sodium saccharin 0.05 Ethanol 35.00 Sorbitol
3.00 Glopylene glycol 2.00 Polyoxyethylene hydrogenated castor oil 1.00 Tween so
1.o.

;Fragrance 1. .

. Purified water was adjusted to 100% to obtain a phlegm-containing agent in the same manner as in Example 1 above.

Example 6 Composition Chlorhexidine gluconate 0.50 Azulene 0.02 Saccharin sodium 0.05 Ethanol
40.00 Glycerin
3. ,OO propylene glycol
2.00 Polyoxyethylene hydrogenated castor oil 2.00 Perfume 1.00 Purified water Adjusted to 100 g A rutting agent was obtained in the same manner as in Example 1 above.

Example 7 Composition Chlorhexidine gluconate 0.2°Azulene 0.02 Saccharin sodium 0.05 Ethanol
40.00 Glycerin
3.00 Sorbitol
3.00 Glopylene Glycol
3.00 Polyoxyethylene hydrogenated castor oil 2.00 Fragrance 1.00 Purified water 100 Well adjusted A fertilizing agent was obtained in the same manner as in Example 1 above.

All of the clarifiers obtained in Examples 1 to 7 were packed in colorless transparent glass containers and packaged in individual paper cases, and even after being stored at 40'C for 1 month, they were not exposed to sunlight. Even after one month, almost 100% of the azulene remained, giving it a bright dark blue color.

Claims (1)

[Claims] 1 Polyoxyethylene hydrogenated castor oil with 0.01 to 0.1 weight part of azulene, 0.03 to 0.1 weight part of chlorhexidine salt, 20 to 50 weight part of ethanol, and 1 to 2 weight parts of polyoxyethylene hydrogenated castor oil with an average number of added moles of ethylene oxide of 60. A clarifier composition characterized by containing a stimulant.