JPS5932147B2 - syringe connection parts - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to an injection connecting part incorporating a thin tubular filter element and used integrally with a syringe barrel and a syringe needle.

Conventionally, various parts have been proposed as parts having a filter function for use in syringes.

However, they do not have sufficient filtration performance, the manufacturing process for making them into parts is complicated, the preparation process for use is not simple, and for these reasons, they cannot be disposed of.

In order to provide a syringe connection part that can be used as a disposable, compact and easy to handle, the inventors of the present invention have carefully studied the material, structure, and processing process of the syringe connection part. The inventors have now invented the syringe connecting part of the present invention, which is small, easy to use, and has good performance.

The present invention was achieved by successfully developing a thin tube-shaped filter element that is extremely useful as a filter material.
This was achieved for the first time.

By integrating the tubular filter element, an open end connectable to a syringe barrel, and an open end connectable to a syringe needle, a small and easy-to-use syringe connecting part can be replaced.

First, a specific example of the present invention will be explained according to the drawings.

FIG. 1 shows a cross-sectional structure of one example of the syringe connecting part of the present invention.

In this figure, the outer diameter is 1.8 vurt and the length is 40 mm.
A thin tubular filter element 1 is made of plastic having a tapered hole so that it can be adhered to a syringe, and an insertion hole at one end having a diameter of 1.8 mm, which is equal to the outer diameter of the tubular filter. It is inserted into Hole Goo 2 and fixed with adhesive 3.

The hollow part of the thin tubular filter element 1 is closed at only one end 4 and open at the other end, and the side with the opening is inserted into the hole.

In addition, the hole goo 2 has a structure in which the insertion hole of the hole goo and the tapered hole are connected to form a flow path for the overflow fluid.
It is an integrally molded plastic product.

A case 5 is placed over the outside of this tubular filter element.

The tip 6 of the case 5 is a tapered protrusion that can be inserted into an injection needle.

The hole goo 2 and the case 5 are airtightly integrated by means of adhesive, heat fusion, or the like.

If the dimensions of Hole Goo 2 and Case 5 are properly matched, it is possible to assemble Case 5 airtightly by simply fitting it into Hole Goo 2.

If Hole Goo 2 is made of an elastic material, assembly will be even easier.

FIG. 2 shows a syringe connecting part to which three filter elements 1 are attached.

The filter element 1 is inserted into a hole 7 having three holes having the same diameter as the outer diameter of the filter element 1.

3 is a bonding part, and 5 is a case.

FIG. 3 shows a hole group 7 used for assembling the syringe connecting part with three filter elements shown in FIG.
Holes 8 having the same diameter as the filter element 1 are bored at three locations.

In this example, the diameter of the hole 8 is 1.8 mm, the maximum diameter of the hole is 12 mm, and the length is 25 mm, and the filter element 1 has an outer diameter of 1.8 mm, a length of 4071!71, and the total length including the case 5. is 70 dragons.

As shown in the specific examples above, the present invention is characterized by having a thin tube-shaped filter element, an open end connectable to a syringe barrel, and an open end connectable to a syringe needle. The two open ends are not connected by the hollow part of the thin tubular filter element, and a continuous closed space sandwiched between the two open ends serves as a source of liquid present in at least a part of the outside of the thin tubular filter element. Divided by a solid polymer wall and a thin tubular filter element, one of the divided spaces is connected to an open end that can be connected to a syringe barrel, and the other divided space is connected to a syringe needle. It is connected to a connectable open end.

That is, a thin tube-shaped filter element, a syringe barrel, and a connecting opening end of a syringe needle are used, and a syringe connecting part that can only be put to practical use is made by combining these elements.

Further, for the purpose of filtration, the fluid to be treated must be filtered by the wall of the filter element, and therefore, the syringe connecting part of the present invention must have the above structure.

Furthermore, as shown in Figure 1, the polymer wall may be composed of a whole goo polymer, or a whole goo polymer and an adhesive polymer, or it may be composed of only a polymer such as an adhesive. (G)

Further, the open end connectable to the syringe barrel does not have to be formed of a hole as shown in FIG.

For example, a tubular filter element may be provided in a hollow case, and the open end formed separately may be integrated with an adhesive or the like.

However, the present invention makes it easier to assemble by using a special hole goo, which is an integrally molded part with a hole having the same diameter as the outer diameter of the filter element and an opening at the other end that can be connected to a syringe barrel. is facilitated and gives particularly favorable results.

The effect of using this whole goo is meaningful only when the number of tubular filter elements is small.
The limit is 10 or less, particularly preferably 4 or less, and most preferably 1.

The tubular filter element used in the present invention preferably has an outer diameter of 3 mm or less.

If the diameter is larger than 3 mm, the tube's ability to maintain its own shape will decrease, making it more likely to collapse when suctioned.

The inner diameter may be large enough to allow fluid to pass through, but is preferably 0.1 mm or more, particularly preferably Q, 5 mm.
That's all.

The size of the sieve mesh of the filter element can vary depending on the purpose of use.

In general, it is preferably 0.05μ or more and 10μ or less.

As will be described later, the component of the present invention is used to separate P from plasma, which takes advantage of the features of the present invention.

For this plasma separation, if a filter with a sieve size larger than 0.5μ is used, blood cells may get stuck in the sieve when filtering the plasma, or sometimes some blood cells may pass through the filter and become clogged. Therefore, it is not possible to separate only blood cells.

Therefore, the size of the sieve mesh of the filter element is 0.51t
Must be below.

In addition, the filter element can be used even if it is bent into a U-shape with both ends open, but for ease of assembly, one end is open and the other end is closed and tube-shaped. It is desirable that there be.

The open end is used as an inlet for the liquid to be treated or an outlet for the p-liquid.

The filter element also has a length to outer diameter ratio (L/D
) is preferably 10 or more and 200 or less.

When it is less than 10, the effective membrane area becomes small and filtration cannot be carried out in a short time.

Also, if it exceeds 200, it will be difficult to use as a filter (S).

When using a plurality of filter elements, it is particularly preferable that the nucleation is 50 or less.

This filter element has a thin tube shape and is strong, but a tube-shaped reinforcing body made by knitting fibers, such as a tube-shaped braid and a membrane material constituting sieve mesh, is used to form the filter element. In some cases, it is particularly preferable to use a tubular filter element that is integrally molded, since this results in a strong filter element even if a weak membrane material is used.

Next, an example of a method for manufacturing the tubular filter element used in the present invention will be described.

FIG. 4 is a schematic diagram of a manufacturing apparatus for this filter element.

3 parts of cellulose diacetate, 6 parts of cellulose triacetate, 62 parts of methylene chloride, 25 parts of methanol, and 4 parts of water are put into a stock solution dissolution tank 10 equipped with a stirring device 9, and dissolved and defoamed.

This stock solution is passed through a strainer 12 by a gear pump 11.
and feed it into the mouthpiece 13.

On the other hand, a polyester braid 15 having an outer diameter of 1.6 mrn and an inner diameter of 0.9 mm is fed through the braid inlet 14 installed above the cap, and the braid coated with the undiluted solution passes through the cap outlet 1.
6 and sent to a drying tower 17.

Air is sent into the drying tower through the vent hole 18 to dry the porous tube, and air containing solvent gas is sent through the exhaust hole 19.
taken outside.

On the other hand, the dried porous tube is wound up by a winding machine 20.

The obtained porous tube is further sufficiently dried in a hot air dryer maintained at 80°C.

The outer diameter and inner diameter of the obtained porous tube were 1.8 mm and 0.7 myin, respectively.

When its cross section and surface structure were observed with a scanning electron microscope, its walls had a sieve mesh with a mesh-like porous structure of about 0.2 μm.

By changing the composition ratio and concentration of cellulose diacetate and cellulose triacetate in the spinning stock solution, porous tubes with different sieve mesh sizes can be obtained.

Cut this porous tube and heat and melt one end, or
Alternatively, when sealed with a silicon adhesive, the filter element is preferably used in the present invention.

The syringe connecting part of the present invention has a simple structure and can be used alone.
Moreover, it can be gas sterilized, packaged, and provided to the user in an integrated state with the syringe barrel and needle.

The most preferable way to use the parts of the present invention, which have a simple structure and do not require any special preparation process before use, is to use them only once and then throw them away, taking advantage of the features of the present invention. .

Next, plasma separation will be described as one of the applications that takes advantage of the features of the present invention.

Connect the syringe barrel and needle to the syringe connection parts shown in Figure 1 or 2, stick the needle into the blood vessel, pull out the syringe tube, and aspirate. At the same time, you can collect blood directly from the blood vessel and extract only plasma from the blood. Can be separated.

Such a direct separation method is unprecedented.

Furthermore, by attaching the syringe connection parts shown in FIG. 1 or 2 to the extracorporeal blood circulation circuit using a three-way stopcock or the like, it is possible to take out only plasma from the blood circuit.

In this case, it is possible to sample only plasma from the blood circuit by connecting the syringe needle connection part to the three-way stopcock, connecting the syringe barrel to the syringe connection part, and aspirating with the syringe barrel.

Note that the parts of the present invention can be used as a filter without using a syringe needle or syringe, but this is not a method of use that fully takes advantage of the features of the present invention. It is preferable to connect and use it.

As described above, the present invention uses a thin tubular filter element and integrates the syringe barrel connecting end and the syringe needle connecting end, thereby providing a syringe connecting part that is easy to use with a receiving mold and has excellent performance. can.

[Brief explanation of drawings]

FIG. 1 is a longitudinal sectional side view of an example of the syringe connecting part of the present invention;
Fig. 2 is a longitudinal side view showing an example of a syringe connection part using three filter elements, Fig. 3a is a longitudinal side view of a hole goo using three filter elements, and Fig. 3A is a front view of the same. , FIG. 4 is a schematic diagram showing an example of a manufacturing apparatus for a filter element. 1...Filter element, 2...Hole goo, 3...Adhesive, 4...Closed end,
5... Case, 6... Syringe needle connection end, 7...
...Hole goo, 8...Filter element insertion hole.

Claims (1)

[Scope of Claims] 1. A hollow part of the thin tube-shaped filter element, which has a thin tube-shaped filter element, has an open end connectable to a syringe barrel, and an open end connectable to a syringe needle. In some cases, the open ends are not connected, and a continuous closed space sandwiched between the open ends is formed by a thin, liquid-free polymeric wall that is present on at least a portion of the outside of the narrow tubular filter element. It is divided by a tubular filter element, and one of the divided spaces is connected to an open end connectable to a syringe barrel, and the other divided space is connected to an open end connectable to a syringe needle. A syringe connection part characterized by: 2. The syringe connecting part according to claim 1, wherein the tubular filter element has an outer diameter of 3u+ or less and a sieve mesh size of 0.05μ or more and IOμ or less. 3. The syringe connecting part according to claim 1, wherein the tubular filter element has an outer diameter of 3 mm or less and a sieve mesh size of 0.05 μm or more and 0.5 μm or less. 4 One end of the tubular filter element is closed and the other end is open, and the length to outer diameter ratio (L/
D) is 10 or more and 200 or less
Syringe connection parts as described in section. 5 One end has an opening that can be connected to a syringe, the other end has a filter element insertion hole with the same diameter as the outer diameter of the tubular filter element, and the insertion hole and the opening are connected. A holder that is an integrally molded body is used, and an end portion of a tubular filter element having an opening is bent and fixed in a filter element insertion hole of the holder to form a syringe barrel connection side. The syringe connecting part according to item 1.