JPS5934681B2 - microbial inhibitor - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel microbial inhibitor for foods or other materials.

In general, the harmful effects of microorganisms on foods or other materials, such as paints and cosmetics, are extremely large, and therefore methods for preventing them are highly desired.

Theoretically, the correct way to prevent this is to maintain it in a sterile state, but in reality this is completely impossible.Therefore, the preferred method is to use simple methods such as disinfectants and fungicides. becomes.

However, many conventional fungicides and fungicides have drawbacks such as variability in effectiveness and toxicity.

For example, the effect of sorbic acid can be reduced by changing the pH.
Therefore, it is only practical to use it in the optimum condition, and the range of use is therefore limited.

Furthermore, nitrofuran derivatives, particularly freelfuramide, which are the most effective food preservatives, are highly toxic and are useful only when added in extremely small amounts.

Although pentachlorophenol and the like are effective as antifungal agents for paints, they are highly toxic and have a tendency to accumulate residue, so they are undesirable as they cause environmental pollution.

The present invention is directed to providing useful compounds that overcome the drawbacks of the conventional products mentioned above.

That is, it relates to a microbial inhibitor containing 2,7-dimethyl-1,7-octagenyl-3-ol, a compound represented by the following structural formula, as an active ingredient.

Unlike conventional products, the substance according to the present invention is a compound that is less toxic, has no tendency to reduce its effectiveness due to pH fluctuations during use, and has less tendency to accumulate residue.

2,7-dimethyl-1,7-octagenyl-3-ol is produced by reacting isoprene in the presence of carbon dioxide gas and water in a solvent system or an emulsion system using a baradium catalyst with phosphines as ligands. I can do it.

This substance has the following physical properties. Boiling point 96-99℃/10
#H,! i+ 17.5 Refractive index "D 1.4709 The acute toxicity of the substance of the present invention is LD5o after oral administration to mice.
7,! It is similar to sorbic acid as it shows an i'/ of 9 or more, and in addition, its effect varies little depending on pH.

Therefore, it has been shown that adding 11,500 to 1/2,000 to foods such as fruit juices and dairy products, cosmetics, and paints provides excellent effects.

Examples will be explained below.

Example 1 A 50% aqueous glycerin solution of 2,7-dimethyl-1,7-octagenyl-3-ol according to the present invention and a control sorbic acid was prepared.

Next, Escherichia c.
oli), Staphylococcus aureus
us aureus), Bacillus subtilis
btills), baker's yeast (Saccharomyc
escerevisae), black mold (Aspergi
llus niger), blue mold (Penicill)
Chrysogenum) was selected.

Next, the medium for bacteria is ordinary agar medium pH 7.0, and the medium for yeast mold is potato grape sugar-agar medium pH 7.0, and the sample concentration in the medium is 1000.500.
, 250, 125, and 62.5 μg/ml.

Next, each of the above test bacteria was inoculated into these, and the bacteria were incubated at 37°C.
The yeast and mold were cultured at 25° C. for 5 days, and the presence or absence of growth was observed.

The results of this test are shown in Table 1.

As is clear from the above table, the substance of the present invention was equivalent to sorbic acid with respect to fungi, but superior results than sorbic acid were obtained against black mold and blue mold.

Example 2 Vanishing cream (stearic acid 120, beeswax 4.0, liquid paraffin 6.0, surfactant 4.0
, lanolin 1.0, glycerin 5.0. (0.3 parts of triethanolamine, 67.7 parts of water) and 2,7-dimethy)V-
Blue mold spores were inoculated into those containing 0.2% of 1,7-octagenyl-3-ol and those containing no additive.
℃ for one month.

As a result, no mold growth was observed in the product to which this compound was added, but active mold growth was observed in the product without the additive.

Example 3 0.1% of the compound of the present invention was added to an oil-based paint (manufactured by Nippon Paint ■, vinyl acetate resin emulsion), and this was
Coated on water-resistant veneer plywood to a thickness of 0.9% and heated at 27°C.
The samples were left in a constant temperature room with a humidity of 80% and examined for mold growth.

The results, as shown in Table 2, demonstrate the superiority of the present invention.

Summer mandarin marmalade is made by a conventional method, and at the end of the final manufacturing process (sugar content adjustment process), 2,7-dimethyl-1,7
-Octagenyl-3-ol at 0.0% relative to the weight of the product.
2% was added and stirred uniformly.

On the other hand, we produced products without the addition of this compound, and tested these two products with blue mold (Penicillium chry).
sogenum) spores were inoculated in large quantities under the same conditions and left at 25°C for 30 days.

As a result, no growth of bacteria was observed in the product containing 0.2% of this compound, but in the non-additive control product, the growth of mycelia was observed on the 6th day, and the settlement of spores was observed on the 100th day. .

It is clear from this that the present invention is superior.

Claims (1)

[Claims] A microbial inhibitor characterized by containing 12,7-dimethyl-1,7-octagenyl-3-ol as an active ingredient.