JPS594137B2 - butt exhaustion - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention uses hollow fibers (simply referred to as "hollow fibers" in the present invention) having a continuous hollow cavity as a semipermeable membrane, and blood flowing inside the hollow fibers, Fluid flowing outside the hollow fibers (referred to as extra-fiber fluid in the present invention).

), through the semipermeable membrane of the hollow fiber, and in particular, the processing time is determined by adjusting the flow rate or flow velocity of the fluid flowing outside the hollow fiber, that is, the fluid outside the fiber. This relates to a blood processing device that can be used for the purpose of shortening the blood flow rate or increasing the purification effect.

Conventionally, a large number of semipermeable hollow fibers, approximately 10,000 semipermeable membranes, are arranged in parallel and bundled into a cylindrical shape, and each fiber bundle is placed straight into a cylindrical container having an inlet/outlet for fluid flowing outside the hollow fibers. In order to prevent the fluid flowing outside the hollow fiber and the fluid flowing through the inside of the hollow fiber from mixing without intervening the membrane of the hollow fiber. , only at both ends of the hollow fibers, the voids between the fibers and the voids between the fibers and the container wall are liquid-tightly bonded with an adhesive to serve as a support device and partition device for the hollow fibers; 2. Description of the Related Art A fluid treatment device is known in which an inlet and an outlet for a fluid flowing inside the fibers are formed at both ends of a bundle.

However, in this device, a large number of hollow fibers are packed relatively densely and filled almost completely in a cylindrical container, so the fluid flowing outside the fibers evenly fills the gaps between each hollow fiber. It is nearly impossible for the water to flow, and in some places it does not flow sufficiently, creating stagnation.

Therefore, there is a membrane surface that is not fully utilized, and the advantage of using hollow fibers, which is a large membrane area per unit container volume, is not fully utilized. The movement effect was still not sufficient.

Furthermore, even if an attempt is made to provide sufficient gaps between the hollow fibers in order to eliminate the above-mentioned drawbacks, it is technically difficult to arrange the thin hollow fibers with equal and even sufficient gaps. It is overwhelming and impossible to realize.

Moreover, even if such a device were to be used as an artificial kidney device by flowing blood inside the fibers,
If the volume of the container is large, the blood outlet at the end of the fiber bundle will also be large, which may exceed the limit of the amount of blood that can be taken out of the patient's body during blood purification. This made it difficult to use it as a blood processing device.

Furthermore, in the conventional device described above, since a large number of hollow fibers are relatively densely bundled and filled all over the wall of the cylindrical container, it is difficult to control the flow rate or flow velocity of the fluid flowing outside the fibers. However, if the flow rate or flow rate were forcibly increased, the fluid would flow only where it could easily flow, and in any case, it was difficult to shorten the processing time with this device.

The present inventors have already proposed a hemodialysis device in which a large number of semipermeable membrane hollow fiber bundles, both ends of which are bound and bonded, are housed in a container. one of the containers, the other, is on the left, and the other, the other, is on the right; b) the container has an inlet for extrafiber fluid at the bottom; c) The container has an outflow port for the extra-fiber fluid over the entire upper part; d) The container gradually expands from the extra-fiber fluid inlet toward the hollow fiber bundle. He invented a device and applied for a patent.

The present inventors further improved the outflow port side of the fiber AN body of the above-mentioned device, and came to invent a device that can particularly efficiently circulate and use the fiber IA raw material.

The device of the present invention is a blood processing device in which a large number of semipermeable membrane hollow fiber bundles with both ends bound and bonded are housed in a container, and is characterized by having the following configurations (a) to (d). (a) one of the ends of the hollow fiber bundle is in one of the containers and the other one is in the other of the containers;

(b) The container has an inlet for the fiber 'AH body in a direction substantially perpendicular to the hollow fiber bundle at a central portion of the fibers that is substantially equidistant from both ends of the hollow fiber bundle, and the container has an inlet for the fiber 'AH body in a direction substantially perpendicular to the hollow fiber bundle, and the inlet is approximately equidistant from both ends of the hollow fiber bundle. Having the outlet of the fiber IAH body in the opposite direction.

(c) the container gradually widens from the fiber IA fluid inlet and outlet toward the hollow fiber bundle;

The device of the present invention has a structure in which the hollow fiber bundle gradually expands from the fiber 'AN body inflow inlet and inflow inlet, and gradually narrows from the hollow fiber bundle toward the fiber array fluid outlet. Therefore, the flow rate or flow rate of the fiber 'Aa body can be increased to uniformly contact the fiber IA raw fluid hollow fiber.

Therefore, the apparatus of the present invention can shorten processing time and increase the purification effect, and is suitable for efficient circulation of extra-fiber fluid.

That is, in the above-mentioned prior invention of the present inventors, when recycling the fiber IAH body from the economical point of view of the fluid outside the fiber,
An outer fence was required to store the fluid flowing out from the fiber IA raw fluid outlet, and an extra amount of fiber IA raw fluid corresponding to the capacity of the outer fence was required.

The present invention does not require such an outer fence.

In addition, from the viewpoint of purification effect, it is preferable that the ends of the fiber bundle consisting of a large number of hollow fibers are bound together with an adhesive, and the unsupported portions can be moved to some extent.

When fixing such a fiber bundle in the container of the present invention, it is preferable to use it with a moderate amount of slack rather than being stretched at both ends to give the fibers a degree of freedom.

In order to sufficiently enhance the blood purification effect (or to shorten the processing time), the fiber I in the container of the device of the present invention is
It is preferable that the raw fluid flow path A widens in the direction connecting the inlet and outlet of the fiber array fluid, and is narrow in other directions so that the fiber fluid does not flow outside the fiber bundle.

Next, the present invention will be explained in more detail using drawings showing embodiments of the apparatus of the present invention.

FIG. 1 is a perspective view showing an example of the device of the present invention, FIG. 2 is a sectional view at the center of FIG. 1, and FIG. 3 is a sectional view taken along line xx' in FIG. 2. .

A large number of hollow fibers 1, for example several hundred fibers, preferably several thousand to several hundred fibers, as shown in FIGS.
A blood inlet 4 and a blood outlet 5 are provided at both ends of the bundle of fibers that have been bundled and bonded.

Such fiber bundles may be those shown in US Pat. No. 3,228,876.

This bundle of hollow fibers is housed in a container 6.

As shown in FIG. 2, the structure of this container 6 is such that it gradually expands from the extra-fiber fluid inflow lower towards the 10 bundles of hollow fibers, and gradually narrows from the 10 bundles of hollow fibers towards the fiber/A fluid outlet 8. There is a need.

Furthermore, although the hollow fiber bundle can be covered with a net or the like, it is inappropriate to make the cover have a structure that obstructs the movement of the fibers.

However, depending on how the device of the present invention is used, the fibers may move too much and break the fibers. In such a case, a net or the like is installed on the fiber IA fluid outflow side of the fiber bundle to prevent the movement of the fibers. It is preferable to restrict the amount appropriately.

Although it is possible to use a control rod instead of the net, it is preferable to use a mesh body such as a net.

In addition, a flow dividing plate may be used as an auxiliary means in order to more uniformly diffuse the fiber lAH bodies into the fiber bundle or to cause them to flow more evenly to the outlet; however, such an auxiliary means The device of the present invention can achieve its purpose even without using.

When the device described above is used as an artificial kidney, the blood purification efficiency is very high, and when the same purification rate as the conventional device is sufficient, the time required to purify the blood can be shortened, and , the device can be made smaller if the same purification rate and the same amount of time are required.

Such shortening of the required time and reduction in the amount of filled blood caused by making the device smaller can reduce the burden on the patient.

As described above, the device of the present invention is particularly excellent when used as an artificial kidney.

[Brief explanation of the drawing]

FIG. 1 is a perspective view of the apparatus of the present invention, FIG. 2 is a central sectional view, and FIG. 3 is a sectional view taken along line xx' in FIG. 1...Hollow fiber, 2...Hollow fiber bundle end, 3...Hollow fiber bundle end, 4...Blood inlet, 5... ...Blood outflow port, 6.・、・・・
Container, 7... Fiber IA fluid inlet, 8...
...Fiber IAIt body outflow port.

Claims (1)

[Scope of Claims] 1. A hemodialysis device in which a bundle of multiple semipermeable hollow fibers with both ends bound and bonded is housed in a container, including: a) one of the ends of the hollow fiber bundle is b) the container contains fibers in a direction substantially perpendicular to the hollow fiber bundle in the center approximately equidistant from both ends of the hollow fiber bundle; C) the container has an inflow of the extrafiber fluid] and an outlet for the extrafiber fluid in a direction substantially opposite to the inlet; C) the container has an inflow of the extrafiber fluid;
and gradually expanding from the outlet toward the hollow fiber bundle.