JPS596842B2 - toothpaste composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a dentifrice composition, and an object of the present invention is to provide a toothpaste composition that is effective in removing bad breath and does not cause discomfort when used in dogs.
Moreover, the objective is to provide a toothpaste composition that is comparable in other functions such as a refreshing feeling.

Oral odor, so-called bad breath, can have a negative impact on a person's social life in some way because it makes others feel uncomfortable.

Depending on the cause, this bad breath is classified into (@) bad breath caused by the oral cavity, (mouth) bad breath caused by diseases in internal organs other than the oral cavity, and bad breath caused by food and drink. Bad breath is caused by (a), which accounts for about 90% of the total.

There are several toothpaste compositions aimed at removing bad breath, but most of them contain bactericides, but there are various problems such as toxicity and deactivation in the toothpaste composition, and they are not necessarily effective. is not enough.

On the other hand, it is also considered to indirectly prevent bad breath by incorporating anti-inflammatory agents and having a symptomatic effect on the oral diseases that cause them, especially stomatitis and periodontitis.
There are problems in stabilizing the formulation into dentifrice compositions, and it has not been put into practical use.

The evaluation of each currently known active ingredient is shown in the table below, and the major drawback of all of them is that they are not compatible with bad breath removal effect and stability during tooth brushing.

The present invention has been made in view of the above, and uses stearylglyterrethenate and/or 3-stearoxyglyterrethenate, which are derivatives of glycyrrhetinicacid, obtained by hydrolyzing glycyrrhizin contained in licorice. The present invention relates to a dentifrice composition characterized by containing thenic acid.

The stearyl glycerrethenate used in the present invention is
It is represented by the chemical formula below, ? Here, R=-(CH2)1-CH3) Also, 3-stearoxyglycyrrhethenoic acid is (here, R1-C-
(CH2)ta-CH3).

Although these compounds are fat-soluble, they are well compatible and solubilized with surfactants, which are the main ingredients in toothpaste, so they are sufficiently dispersed in the oral cavity and have a high effect on removing bad breath. be.

Furthermore, these compounds have almost no toxicity and are tasteless and odorless, so they do not give an unpleasant feeling when using toothpaste and do not impair the refreshing feeling that toothpaste inherently has. It was stable even in the middle of the day, and there were no problems even when stored for a long period of time.

The blending ratio of this compound in toothpaste is 0.001 to 5% by weight,
Preferably o. ooi~1% by weight.

The reason for this is that if it is less than 0.001% by weight, it is difficult to expect the desired effect, and if it is blended in more than 5% by weight, it is uneconomical and the feeling of use is somewhat impaired.

Other dentifrice ingredients used in the present invention include abrasives, binders, viscosity agents, surfactants, fragrances, sweeteners, etc., and known ones can be used.

Typical abrasives include, for example, dicalcium phosphate,
Mention may be made of insoluble sodium metaphosphate, calcium carbonate, aluminum hydroxide, silica, alumina, etc., and mixtures thereof.

Surfactants include anionic, nonionic, amphoteric,
Although either cationic or cationic agents can be used, it is preferable that the agent has a cleaning action and imparts cleaning properties and foaming properties to the composition.

These include sodium lauryl sulfate, sodium olefin sulfonate, sodium lauroyl sarcosinate, acyl taurates, lauric acid monoglyceride sulfate, lauric acid monoglyceride sulfonate, iseteonate, lauryl diethanolamide, sucrose esters, stearic acid monoglyceride, Examples include polyoxyethylene sorbitan monolaurate.

This compound may be used in combination with other active ingredients such as sodium monofluorophosphate, soot fluoride, sodium fluoride, sodium phosphate, bactericides, dextranase, and mutanase.

The effects of the present invention are demonstrated by the following clinical experiments.

[Clinical experiment 1] ■ Panel and period A 39 women's junior college students were stratified into 2 groups of 19 and 20, and the following toothpaste samples were distributed to each group.
I used it continuously for a week.

1st group - 0.006% stearyl glycyl rethenate toothpaste 2nd group - 0 alpha amylase
．． Toothpaste containing 1% (100 units/gram toothpaste) A third group consisting of 20 people was prepared as a control group, and they were made to use a toothpaste sample that did not contain any bad breath removing ingredients.

(Placebo) ■Testing method Before the start of the clinical experiment, all panelists were asked through a questionnaire whether they felt uncomfortable or had bad breath.

After the sample distribution, the presence or absence of bad breath was similarly asked through questionnaires during the intermediate two weeks and on the final day of the experiment.

■Result 1. Discomfort 2. Regarding the data on bad breath "discomfort 9", when we performed a statistical significance test on the number of owners of the two types of samples on the final day of the clinical trial compared to the number of owners before the clinical trial, we found that there was a difference of 5 between the two types of toothpaste samples. % significant difference was observed.

Furthermore, it was found that there was a difference at a significance level of 15% between the two sample toothpastes in terms of bad breath.

Next, examples of the present invention will be shown.

Example 1 Toothpaste dicalcium phosphate 40.0% (weight) Na
Monocarpoximethe 1.0 Norecenolose glycerin 25.0 Sodium saccharin 0.2 Sodium lauryl sulfate 1.5% (by weight) Flavoring 1.0 Stearyl glycerol 0.004 Tinate water Residual ioo. o Example 2 Toothpaste dicalcium phosphate 42.0% (weight) Na
Monocarboxymeterse 0.9 Norelose Sorbitol 30.0 Sacchulin Sodium 0.2 Sodium Olefinsulfonate 1.5 Lithium Flavor 1.0 Stialglyterenane} 0.1 Water
Remaining 100.0 Example 3 Toothpaste Calcium Carbonate 40.0% (weight) Na
Monocarpoxymethylcetate 1.0 Norelose Sorbitol 25.0 Satucalin Sodium 0.2 Sodium Olefinsulfonate 2.2 Lium Flavor i. o Stialglycyllethene 0.8 Water balance 100.0 Example 4 Toothpaste calcium carbonate 40.0% (weight) Na
Monocarboxymethyl 0.5 Senorerose iritus moss 0.5 Glycerin 23.0 Sodium saccharin 0.18 Sodium lauryl sulfate 2.5 Fragrance 0.9 Stearglyterretine 1. All the toothpastes with a balance of 100.0 or more had a good effect on preventing bad breath.

In addition, a toothpaste with the composition of Example 4 containing the following anti-inflammatory agents in addition to stearylglyterrethenate was prepared, and each toothpaste was used for 4 consecutive weeks on a panel of 10 people with bad breath. The presence or absence of bad breath was determined subjectively.

Panel Anti-inflammatory agent 2 weeks later 4 weeks later 1
1.0% Stearyl Almost not felt Glyterrethene Not felt 2
〃
〃3 1.0%3-steer //
//Roxyglytyrrhetenoic acid 4 // // Almost not felt 5 1.0 Glycyrrhetenoic acid Feel Sensible 6 〃 〃
〃7 1.0% Alantoy /l
//n8 ////
//9 1.0% photosensitive element /l
//No. 101 Q //
// /1 From the above results, 3-stearoxyglycyrrhetinic acid, in addition to stearylglycyrrhetinate, has a similarly excellent halitosis prevention effect, but glycyrrhetinic acid, allantoin, and the anti-inflammatory agent Photosensor No. 101 It can be seen that the effect of preventing bad breath cannot be obtained.

In addition, in addition to the toothpaste having the composition of Example 3, a toothpaste was prepared in which 0.8% of each of the glycerrethenic acid derivatives shown in the following table was blended in addition to stearyl glycyl rethenate.
This was stored in a constant temperature bath at 40°C, and the degree of discoloration due to deterioration of the glycyrrhthenic acid derivative was examined.

Furthermore, in addition to stearyl glycerrethenate, a toothpaste containing 1% of each of the glycyrrhethenoic acid derivatives shown in the following table was prepared in the toothpaste having the composition of Example 4, and this was stored in a constant temperature room at 40°C. The residual rate of each derivative was determined.

The results are also shown in the table below.

From this result, among various glycerrethenic acid derivatives, 3
- It can be seen that stearoxyglyterretinate acid and stearylglytyl rethenate are excellent in discoloration and residual rate.

Claims (1)

[Claims] 1 stearyl glycerretinate and/or 3-
Stearoxyglytellethenoic acid was added o. A dentifrice composition characterized in that it contains ooi to 5.0 parts by weight.