JPS597681B2 - hair growth promoter - Google Patents
hair growth promoterInfo
- Publication number
- JPS597681B2 JPS597681B2 JP16402779A JP16402779A JPS597681B2 JP S597681 B2 JPS597681 B2 JP S597681B2 JP 16402779 A JP16402779 A JP 16402779A JP 16402779 A JP16402779 A JP 16402779A JP S597681 B2 JPS597681 B2 JP S597681B2
- Authority
- JP
- Japan
- Prior art keywords
- hair growth
- growth promoter
- cysteine
- acid
- alopecia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000003779 hair growth Effects 0.000 title claims description 11
- 239000007952 growth promoter Substances 0.000 title claims description 7
- 239000002253 acid Substances 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- 235000014113 dietary fatty acids Nutrition 0.000 claims description 2
- 229930195729 fatty acid Natural products 0.000 claims description 2
- 239000000194 fatty acid Substances 0.000 claims description 2
- DLLMHEDYJQACRM-UHFFFAOYSA-N 2-(carboxymethyldisulfanyl)acetic acid Chemical compound OC(=O)CSSCC(O)=O DLLMHEDYJQACRM-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 235000018417 cysteine Nutrition 0.000 description 9
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 9
- 201000004384 Alopecia Diseases 0.000 description 8
- 231100000360 alopecia Toxicity 0.000 description 6
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 description 5
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 230000002159 abnormal effect Effects 0.000 description 2
- 208000004631 alopecia areata Diseases 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000003676 hair loss Effects 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000021 stimulant Substances 0.000 description 2
- 239000011593 sulfur Substances 0.000 description 2
- 229910052717 sulfur Inorganic materials 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 241000208293 Capsicum Species 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 229960002504 capsaicin Drugs 0.000 description 1
- 235000017663 capsaicin Nutrition 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007850 degeneration Effects 0.000 description 1
- 230000003412 degenerative effect Effects 0.000 description 1
- HNRAOCKXXJDELP-UHFFFAOYSA-L disodium;2-sulfanylacetate Chemical compound [Na+].[Na+].[O-]C(=O)CS.[O-]C(=O)CS HNRAOCKXXJDELP-UHFFFAOYSA-L 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 208000024963 hair loss Diseases 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 210000004761 scalp Anatomy 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000003464 sulfur compounds Chemical class 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
【発明の詳細な説明】
本発明は退化現象による脱毛症に適用する発毛促進剤に
関するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a hair growth promoter applicable to alopecia caused by degenerative phenomena.
従来この種の脱毛症については、これを予防し、あるい
はその進行を遅らせ、若しくはこれを治療する薬剤は種
々あるが、所期の目的を果すものは見受けられない。Conventionally, there have been various drugs for preventing, delaying, or treating this type of alopecia, but none have been found to achieve the intended purpose.
従来の市販の養毛剤は一般的に油脂剤、湿潤剤、皮膚刺
激剤、ホルモン剤、ビタミン剤、アミノ酸類、副文感神
経刺激剤等を、水又はアルコール、若しくはこれらの混
合物に適宜配合して製せられている。Conventional commercially available hair growth agents generally contain oils and fats, humectants, skin stimulants, hormones, vitamins, amino acids, parasensory nerve stimulants, etc., mixed with water, alcohol, or a mixture thereof. It is manufactured.
これら配合薬剤中アミノ酸就中システン、システインが
注目されるのであり、これは毛髪構成成分として重要な
要素を含んでいる。Among the amino acids in these compounded drugs, cysteine and cysteine are of particular interest, and contain important elements as hair constituents.
しかしながら、システンは水又はアルコールに不溶性の
ために配合量が極度に制限され、又、システインは水に
溶解するが経時により、メルカブタン臭を発したり、酸
化されて沈殿を生ずるなどの欠点がある。However, cysteine is insoluble in water or alcohol, so the amount of cysteine to be blended is extremely limited, and although cysteine is soluble in water, it has drawbacks such as emitting a mercabutane odor and being oxidized to form precipitates over time.
システン、システイン以外の硫黄化合物、例えば無機化
合物ではコロイド硫黄、ポリテオン酸塩類など、有機化
合物では硫黄を不飽和化合物に付加させたもの、植物か
ら抽出したものなどあるがこれらも溶解度、安定性、臭
いの点で好ましくない。Cysteine and sulfur compounds other than cysteine, such as inorganic compounds such as colloidal sulfur and polytheonate salts, organic compounds such as sulfur added to unsaturated compounds, and those extracted from plants, are also known for their solubility, stability, odor, etc. Unfavorable in this respect.
これに対し、ジテオグリコール酸又はその塩類は希エタ
ノールに溶解性が良く、無臭で、しかも経時変化を受け
にくく、システン、システインその他の含硫化合物より
優れている。On the other hand, diteoglycolic acid or its salts have good solubility in dilute ethanol, are odorless, and are resistant to change over time, and are superior to cysteine, cysteine, and other sulfur-containing compounds.
そこで本発明は、ジテオグリコール酸又はその塩類を配
合し、退化現象による脱毛症に対する発毛促進剤とした
ものである。Therefore, the present invention contains ditheoglycolic acid or its salts as a hair growth promoter for alopecia caused by degeneration.
以下本発明の実施例を示す。Examples of the present invention will be shown below.
実施例 １ ６０％エタノールで全量１００ｍｌとする。Example 1 Make the total volume 100 ml with 60% ethanol.
乳酸の配合により、異常角質物を容易に除去することが
でき、ＰＨを３〜４に調節する。By adding lactic acid, abnormal keratinous substances can be easily removed and the pH can be adjusted to 3-4.
宙添祷１１ ９ ６０％エタノールで全量１００ｍｌとする。Sora Sosei 11 9 Make the total volume 100 ml with 60% ethanol.
異常角質化の少くない、皮脂漏の多い若はげ＝は円形脱
毛症に有効なものである。Young bald people with a lot of abnormal keratinization and a lot of seborrhea are effective for alopecia areata.
実施例 ３ ６０％エタノールで全量１００ｍｌとする。Example 3 Make the total volume 100 ml with 60% ethanol.
この実施例のものは特に皮膚が敏感な脱毛症患者に有効
である。This example is particularly effective for alopecia patients who have sensitive skin.
これら三つの実施例中のジテオグリコール酸は、鎮痒消
炎作用を有し、かゆみなどにも有効である。The ditheoglycolic acid in these three examples has antipruritic and antiinflammatory effects and is effective against itching.
ジテオグリコール酸に代え、ジテオグリコール酸アンモ
ニウム、ジチオグリコール酸ナトリウム、．又はカリウ
ム等のジテオグリコール酸塩類を用いることができる。Instead of ditheoglycolic acid, ammonium ditheoglycolate, sodium dithioglycolate, . Alternatively, ditheoglycolates such as potassium can be used.
また実施例中、皮膚刺激剤としてカプサイシンに代え、
トウガラシチンキ、カラン油等を用いることができる。In addition, in the examples, instead of capsaicin as a skin irritant,
Capsicum tincture, callan oil, etc. can be used.
更に湿潤剤としてプロピレングリコールに代えグリセリ
ン、ソルビトール等を用いることができ、また乳酸に代
え他のα−オキシ脂肪酸を用いることができる。Furthermore, as a wetting agent, glycerin, sorbitol, etc. can be used instead of propylene glycol, and other α-oxy fatty acids can be used instead of lactic acid.
実施例１０発毛促進剤を脱毛症患者計１０５人に投与し
た６施設での臨床試験結果を下記に示す。Example 10 The results of a clinical trial conducted at 6 facilities in which the hair growth promoter was administered to a total of 105 patients with alopecia are shown below.
なお、投与期間は１〜６ケ月、投与方法は１日１〜２回
頭皮に塗布、とし、効果の判定基準は次のとおりとする
。The administration period is 1 to 6 months, the administration method is application to the scalp once or twice a day, and the criteria for evaluating efficacy are as follows.
著 効・・・・・・・・・著明な発毛がみられるもの。Significant effects: Significant hair growth is observed.
有 効・・・・・・・・・発毛がみられ、患者自身も認
めるもの。Effective: Hair growth is observed and is acknowledged by the patient himself.
やや有効・・・・・・・・・写真の比較にて発毛が認め
られるもの。Slightly effective... Hair growth is observed when comparing photos.
無 効・・−・・・・・・変化をみないもの。Invalid: Something that does not change.
臨床試験結果
著効・・・・・・・・・１２例
有効・・・・・・・・・２３例
やや有効・・−・・−・・・３３例
無効・・・・・・・−・３０例
中止または不明・・・・・・・・・７例
有効率・・・・・・・・・６４．８％
（円形脱毛症を除いた有効率６３．２％）６施設の臨床
試験データを整理すると下記のとおりとなる。Clinical trial results: Excellent efficacy: Effective in 12 cases, Moderately effective in 23 cases, Ineffective in 33 cases...・30 cases discontinued or unknown 7 cases Efficacy rate 64.8% (63.2% excluding alopecia areata) Clinical results at 6 facilities The test data is organized as follows.
いわゆる壮年性脱毛症（若禿）においては、治療過程で
、進行停止や脱毛停止があるだけでも有効と考えられる
。In so-called middle age alopecia (young baldness), it is considered effective to stop the progression or stop hair loss during the treatment process.
従って、有効率６０％以上の成績は十分使用に値するも
のであることを示す。Therefore, results with an efficacy rate of 60% or more indicate that the drug is worthy of use.
Claims (1)
導体を含有し、ＰＨが２−６である発毛促進剤。 ２ α−ハイドロオキシ脂肪酸添加の特許請求の範囲第
１項に記載の発毛促進剤。 ３ 前記ジテオグリコール酸又はその塩類、若しくはそ
の誘導体が０、１〜５Ｗ／Ｖである特許請求の範囲第１
項に記載の発毛促進剤。[Scope of Claims] 1. A hair growth promoter containing dithioglycolic acid, a salt thereof, or a derivative thereof, and having a pH of 2-6. 2. The hair growth promoter according to claim 1, in which α-hydroxy fatty acid is added. 3. Claim 1, wherein the ditheoglycolic acid or its salts, or its derivatives have a power of 0.1 to 5 W/V.
The hair growth promoter described in section.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16402779A JPS597681B2 (en) | 1979-12-19 | 1979-12-19 | hair growth promoter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16402779A JPS597681B2 (en) | 1979-12-19 | 1979-12-19 | hair growth promoter |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5687514A JPS5687514A (en) | 1981-07-16 |
| JPS597681B2 true JPS597681B2 (en) | 1984-02-20 |
Family
ID=15785402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16402779A Expired JPS597681B2 (en) | 1979-12-19 | 1979-12-19 | hair growth promoter |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS597681B2 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0159519A3 (en) * | 1984-03-29 | 1987-02-04 | Asta-Werke Aktiengesellschaft Chemische Fabrik | Use of thio compounds for the prevention of hair fall-out caused by cytostatics |
| ES2081256B1 (en) * | 1994-03-15 | 1996-11-01 | De Cegama Angel Ladron | A COMPOSITION TO DELAY AND AVOID LOSS OF HAIR |
| ATE415101T1 (en) * | 1999-12-29 | 2008-12-15 | Sergei Mikhailovich Zenovich | PHYSIOLOGICALLY ACTIVE AGENTS CONTAINING VICINAL DITHIOGLYCOLS AND THEIR USE IN DIFFERENT ECONOMIC AREAS |
-
1979
- 1979-12-19 JP JP16402779A patent/JPS597681B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5687514A (en) | 1981-07-16 |
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