JPS6030496B2 - compressed tablets - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to compressed tablets, more particularly xylitol and
The present invention relates to novel chewable compressed tablets containing one or more polyhydric alcohols.

Xylitol is a natural sugar alcohol known to be useful as a sugar substitute, especially for children, due to its non-irritating properties. Therefore, xylitol is traditionally used as a sugar substitute in milk chocolate, chewing gum, ice cream, candy gum, puddings, jams, jilly marmalade, etc.
It has also been suggested that xylitol be used in compressed tablets.

Unfortunately, however, it has been found that xylitol has very poor tabletability and therefore compressed tablets containing it do not form satisfactorily. The use of sorbitol as a sugar substitute in compressed tablets is well known in the art.

However, the disadvantages of molding this using sorbitol are that it results in very hard tablets that are too brittle and may have other undesirable properties. The present inventors produced compressed tablets containing xylitol as a sugar substitute that can be chewed by combining xylitol with a polyhydric alcohol such as sorbitol. The present inventors have discovered that it can be produced effectively and economically, and have completed the present invention.

Surprisingly, compared to conventional compressed tablets containing only sorbitol as a sugar substitute, the compressed tablets obtained by the method of the invention are soft and have an improved texture.
On the other hand, compressed tablets containing only xylitol are very coarse and brittle and are difficult to use as practical products.Compared to compressed tablets containing only xylitol, the compressed tablets obtained by the method of the present invention have a suitable hardness. have The present invention provides xylitol as a sugar replacer in an amount of about 10 to 8% by weight and about 10%
Provided are chewable sugar-free tablets immediately compression molded from a dry blended mixture comprising a polyhydric alcohol selected from the group consisting of sorbitol, mannitol and mixtures thereof in an amount of ~8% by weight. It is something.

The present invention also provides dry drying of the xylitol in an amount of 10 to 8% by weight and the polyhydric alcohol in an amount of 10 to 8% by weight.
The present invention provides a method for producing chewable, sugar-free compressed tablets, which comprises blending and directly compressing the resulting dry blend mixture into chewable tablets.

Chewable tablets (e.g., compressed tablets or tablet confections such as compressed peppermint candies) of the present invention may further include xylitol in an amount within the range of about 10 to 8% by weight, preferably about 20 to 6% by weight. about 10-8% by weight,
Preferably, the amount of the polyhydric alcohol is within the range of about 20-6% by weight.

In addition, the tablet of the present invention further contains flavoring agents, colorants, pharmaceuticals,
Preservatives or other materials commonly used in such tablets may be included. In addition to xylitol and polyhydric alcohol, the tablet confectionery of the present invention contains synthetic sweeteners (e.g. saccharin sodium, saccharin calcium, dihydrochalcones, glycyrrhizin,
Glycyrrhetinate ammonium salt, L-asbartyl-
L-phenylalanine (methyl ester), etc. and Stevia (Steviare udiana) leaves, Mi
Raquel Perry (Richardella Dulc ca)
), Serendipity (Diosc)
oreophyllum cumminsii), cyclamate, and the like. The tablet confectionery of the present invention is about 0.01 to 10% by weight of this.
The trowel may contain a flavoring agent, preferably in an amount of about 0.2-0.25% by weight.

Examples of such flavoring agents are as follows. Wintergreen, spearmint oil, peppermint oil, clove oil, bay oil, anise oil, eucalyptus oil, thyme oil, cedar leaf oil, cinnamon oil, nutmeg oil, sage oil, bitter almond oil, cassia oil and mixed fruit or natural or synthetic fruit flavors (eg ascorbic acid, citric acid, lactic acid, adipic acid, malic acid, tartaric acid) and spice oils. Further, the tablet confectionery of the present invention can be made into a trowel by containing a lubricant such as calcium stearate, magnesium stearate, or the like. Thus, the tablet of the present invention preferably contains each component in the proportions shown below. Xylitol 30-60%, sorbitol 30-60%, flavoring agent 0.01-2%, lubricant 0.
1-3%. Next, preferred examples of manufacturing the tablets of the present invention will be explained with reference to Examples.

Parts represent parts by weight. Example 1 Manufacture of chewable mint compressed confectionery: 47 parts of xylitol, 47 parts of sorbitol, 55 parts of malic acid, 18 parts of magnesium stearate, 4 parts of raspberry flavor, 0.4 parts of FD&C Red #2 Lake Colorant. parts, 0.04 parts of FD&C Blue #1 Lake Colorant.

The above ingredients are thoroughly dry blended and then compressed into tablets using a conventional tablet compression machine. As a result of comparison with a compressed peppermint confectionery containing no xylitol or sorbitol (control product), the compressed confectionery containing peppermint produced in Example 1 could be compressed more easily than the control compressed confectionery containing mint, and its structure was It was observed to be good and flexible.

Example 2 Production of chewable vitamin preparation: xylitol 47 base, sorbitol 47 base, ascorbic acid 55 parts, stearic acid, magnesium 18 parts,
5 parts Orange Flavor, 1 part FD&C Yellow #6 Lake Colorant.

The above ingredients are thoroughly dry blended and formulated into tablets using a conventional tablet machine.

Compared to vitamins that do not contain xylitol or sorbitol (chewable control vitamins)
It was observed that the chewable vitamin preparation made in Example 2 could be compressed more easily than the control vitamin preparation and its texture was better and had flexibility.

Example 8 Preparation of a chewable vitamin tablet: 47 parts xylitol, 47 parts mannitol, 55 parts ascorbic acid, 18 parts magnesium stearate, 5 parts orange flavor, 1 part FD&C Yellow #6 Lake Colorant.

The above ingredients are thoroughly dry blended and formulated into tablets using a conventional tablet machine. A comparison with a vitamin preparation containing no xylitol or mannitol (chewable control vitamin preparation) revealed that the chewable vitamin preparation prepared in Example 3 was more easily compressed and had a better texture. It was observed that the material had good flexibility.

Example 4 Preparation of Chewable Aspirin: 15 parts powdered aspirin, 597/256 parts sorbitol noxylitol, 2 parts glycine, 7 parts orange flavor, 20 parts stearic acid, 1 part FD&C yellow #6 lake colorant. .

The above ingredients are thoroughly dry blended and this is formulated into tablets using a conventional tablet block.

A comparison with aspirin without sorbitol or xylitol (chewable control aspirin) revealed that the chewable aspirin made in Example 4 was more easily compressed than the control aspirin;
The texture was observed to be good and flexible.

Comparative Example 1 Comparison of compressed sweets containing peppermint: Control product A: 100 parts of xylitol, 4 parts of peppermint oil, 1 part of magnesium stearate.

Control product B: 100 parts of sorbitol, 4 parts of peppermint oil, 1 part of magnesium stearate.

Composition of the present invention: 50 parts of xylitol, 50 parts of solpitol, 4 parts of peppermint oil, 1 part of magnesium stearate
Department.

The three compositions are prepared by dry blending the component materials and then compressing the dry blend mixture directly into tablets in a conventional compression molding machine.

The resulting compressed confectionery moldings had the same weight and size (thickness). The results of comparing these will be explained below. Comparative A, containing only xylitol, is extremely brittle and very pliable and cannot withstand rather rough handling, such as that which occurs during normal packaging operations. Control product B containing only sorbitol
lacks sufficient sweetness and is extremely hard, making it unsuitable as a chewable tablet.

Compositions of the present invention containing xylitol and sorbitol have a pleasant sweet taste, are sufficiently soft to be chewable, and are resistant to repeated, somewhat rough handling during standard packaging operations. It has enough hardness to withstand it.

Claims (1)

[Claims] 1. The tablet contains about 10 to 80% by weight of xylitol and about 10 to 80% by weight of a polyhydric alcohol selected from the group consisting of sorbitol, mannitol, and mixtures thereof. Sugar-free chewable compressed tablets directly compressed from a sugar-free dry blend mixture of 2. The first substance containing a fragrance, a coloring agent, or a mixture thereof.
Tablets of the term. 3. The tablet of item 1 above, containing about 20-60% by weight of xylitol and about 20-60% by weight of sorbitol or mannitol as the polyhydric alcohol. 4 The weight ratio of xylitol and the polyhydric alcohol is approximately 2:
1 to about 1:2. 5. The tablet contains xylitol in an amount of about 30 to 60% by weight, the polyhydric alcohol is sorbitol, and contains sorbitol in an amount of 30 to 60% by weight, and a fragrance of 0.01 to 60% by weight. 2% by weight and 0.1 lubricant
The tablet of item 1 above, comprising an amount of ~3% by weight. 6. Dry blending 10 to 80% by weight of xylitol and 10 to 80% by weight of a polyhydric alcohol selected from the group consisting of sorbitol, mannitol and mixtures thereof based on the total amount of the mixture, and dry blending the resulting dry blended mixture. A process for producing sugar-free chewable compressed tablets, which comprises direct compression into chewable tablets. 7. The method of claim 6, which comprises dry blending xylitol, the polyhydric alcohol, a lubricant and a flavoring agent and directly compressing the resulting dry blend mixture into chewable tablets. 8. The method of claim 6, comprising dry blending xylitol, the polyhydric alcohol, and the drug and directly compressing the resulting dry blend mixture into chewable tablets. 9 The weight ratio of xylitol and the polyhydric alcohol is 2:1
The manufacturing method of item 6 above, wherein the ratio is 1:2. 10 xylitol in an amount of 20-60% by weight and 20
7. The method of claim 6, comprising dry blending sorbitol or mannitol in an amount of ~60% by weight and forming the resulting dry blend mixture into compressible tablets. 11 Xylitol in an amount of 30-60% by weight, 30-6
Sorbitol in an amount of 0% by weight, fragrance in an amount of 0.01-2% by weight and lubricant in an amount of 0.1-3% by weight in a dry manner.
8. The method of claim 7, comprising blending and directly compressing the resulting dry blend mixture into chewable tablets.