JPS6033806B2 - cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention is a cosmetic product characterized by adding a nonionic surfactant in which 10 moles or more, most preferably 15 to 25 moles, of ethylene oxide is added to 2-octyldodecyl alcohol. .

The 2-octyldodecyl alcohol according to the present invention is derived from a linear aliphatic alcohol having 10 carbon atoms in petrochemistry through a gel bed reaction.

Anyone skilled in the art, including the present inventors, can easily think of adding ethylene oxide to these synthetic alcohols to synthesize a nonionic surfactant. This is a very commonly known technology and has been published in literature for a long time. In addition, the present inventors filed an application for the invention of a cosmetic containing a boroxyshetylene type nonionic surfactant having a secondary branched chain structure in Tokkan Sho 48-5-2 (Japanese Patent Application No. 46-39165). There is. However, the present inventors took advantage of these known techniques and documents to synthesize a nonionic surfactant in which ethylene oxide was added to branched 2-octyldodecyl alcohol. As a result of various studies on its properties, we found that the ethylene oxide adduct has unique and good properties within a certain range that have not been seen in conventional cosmetic-quality active agents, and we believe that these properties can be used to create cosmetics that have never existed before. It is believed that this will bring about improvements and progress.

Generally, the requirements and essential conditions for cosmetic raw materials are wide-ranging.

Examples of these conditions are ■ A little odor, ■ A little coloring, and ■ Stable quality and constant supply capacity.

■ Stable over time in terms of heat resistance, light resistance, etc.

■ Relatively stable against microorganisms.

■ Low human skin irritation and toxicity.

Several items are required, such as:

Among these conditions, the substance according to the present invention is far superior to the following commercially available activators, especially activators made from animal and vegetable oils, in terms of items It turned out to be excellent.

In particular, as a result of conducting various experiments on not only ■■, but especially ■■, the present invention found that these are unique and significant substances, and by using these substances in cosmetics, the number of substances has increased even more than before. It can be said that this invention contributed to the advancement of cosmetics. Next, the features of the present invention will be described in detail.

First, the test results for heat resistance and light resistance in Section 4 will be compared with the surfactant according to the present invention and a general commercially available surfactant.

As samples, we used a higher alcohol, which is the mother nucleus of a surfactant, and a surfactant prepared by adding ethylene oxide to it.

1 Polyoxyethylene (4) Oleyl alcohol ether (commercially available activator) [The number of moles of ethylene oxide added (4 moles in this case) is generally expressed as follows. The same applies hereinafter] 2. Oleyl alcohol 3. Polyoxyethylene-like 2-octyldodecyl alcohol ether 4. 2-Octyldodecyl alcohol (activator according to the present invention) The acid value (hereinafter referred to as AV ), peroxide value (POV), and aldehyde value (ALV), and their changes over time were investigated.

In addition, each sample (1, 2, 3, and 4) shows each sample number mentioned above. [Experimental method for heat resistance] The official and tentative method of the American Institute of Oil and Fats
thod) CD-12-57 active oxygen absorption test (A
．． 0. The following test method was used with reference to M).

Test A. 0. Two M test tubes were placed in a temperature bath at 100°C, and dry air was passed through the test tube at a rate of 140 birds/min.

The AV, POV, and ALV are sampled at regular intervals to measure stability against heat. The results are shown in Tables 1, 2 and 3.

Table 1 Changes in AV over time Table 2 Changes in POV over time Table 3 Changes in ALV over time It is clear from the above Tables 1 to 3. It will be clear that between the branched alcohols according to the invention and the surfactants therefrom, the latter active agents according to the invention are very stable and superior.

This can be inferred to prevent or delay material changes caused by heating during cosmetic production or cosmetic deterioration over time during use and storage, and can be said to be an invention that is more useful in stabilizing products. .

In particular, since the present invention relates to active agents used in cosmetics, the effect of the active agent may deteriorate due to some influence on the active agent. , Cream-based products may cause separation phenomena such as unbalanced floating. In order to avoid such problems, it is desirable that the raw material itself be stable under various conditions. Furthermore, the results of an experiment in which carbon arc lamp irradiation was performed to check the stability of cosmetics against light in order to prevent or delay the deterioration of cosmetics due to light during storage are shown below. [Light resistance test method] A carbon arc lamp was irradiated for 3 m hours in a 37q0 constant temperature bath, and samples were taken every 1 hour.
Measure V and POV and evaluate changes over time.

Table 4 Change in AV over time Table 5 Change in POV over time The sample numbers in Tables 4 and 5 are the same as the sample numbers in Table 1.

As is clear from Tables 4 and 5, the stability against light is the overall AV. The change in POV is less than that for heat,
.

In addition, there is a slight difference in the change in AV between a direct mirror higher alcohol based on fats and oils and its activator, a branched type higher alcohol and its activator, and a branched type higher alcohol and its activator. On the other hand, there is a clear difference in the change in POV, and similar to the heat resistance data (Tables 1 to 3), the active agent according to the present invention is more stable. These AV. POV or A
The increase in LV depends on the production of peroxides or aldehydes due to oxidation, and it is clear that these do not have a positive effect on human skin.

At the same time as evaluating the stability of one or more substances, raw materials for salmon products,
Particularly in the case of surfactants such as those of the present invention, the desired effect determines the quality of the substance.

The active agent used in the present invention must exhibit good solubilization with respect to various fragrances, oils, and other substances to be solubilized that are used in daily products. In this regard, a comparative test of solubilizing power with a general commercially available activator was conducted.

[Solubilizing power test method]

1. The following four samples (A and B are commercially available activators, and C and D are activators according to the present invention) were used in the fragrance solubilization test.

Each activator 0. After, 0. 3 levels of 0.8 g, fragrance (floral fragrance mainly composed of jasmine and rose) as a solubilized substance, 0. 95% special grade ethyl alcohol 20
．． After completely dissolving the mixture, add distilled water to make 20 pieces.

After heating for 30 minutes at the temperature (21 to 23 qo), the turbidity is measured. Table 6 Solubilizing power for perfume (commercially available activator) A Polyoxyethylene (15) Oleyl alcohol ether B Polyoxyethylene (20) Oleyl alcohol ether (activator according to the present invention) C Polyoxyethylene (15) 2 -Octyldodecyl alcohol ether ○ Polyoxyethylene (20) 2-Octyldodecyl alcohol ether Results: The lower the number in Table 6, that is, the lower the turbidity, the better the solubilizing power for the substance to be solubilized. It shows
It can be seen that the activators C and D according to the present invention are excellent in terms of the same number of added moles of ethylene oxide as those of A and B, that is, the correspondence of A:C and B:D.

2. As a drug for solubilizing drugs, we attempted to solubilize vitamin E-acetate.

95% special grade ethyl alcohol 10. Female, vitamin E-acetate 0.1g, active agent 1.0, 1.2, 1.5, 2
．． After taking 4 levels of female and completely dissolving, add 80% of distilled water.
After adding a female and incubating at a constant temperature (21 to 2 C) for 30 minutes, the state of turbidity was visually judged.

Table 7 Solubilization for drugs 3 Solubilization for oil 95% special grade ethyl alcohol 20g, non-water-retaining synthetic ester oil as oil content 0. Hey, activator 0.5, 1.0,
1. After taking the 3 levels of the rudder and completely melting it, add 80% distilled water.
0 g was added and the mixture was left at a constant temperature (21:00 to 23:00) for 3 minutes, and then the state of turbidity was visually judged.

Table 8 Solubilization in oil The markings in Tables 7 and 8 above depend on the following judgments.

○: Transparent ■: Transparent with a bluish tint △: Translucent ×:
Cloudy ≠: More cloudy As is clear from the test results of the solubilizing power of these commercially available surfactants 1 to 3 and the new surfactant of the present invention, the surfactant of the present invention is the most important as an active agent. It was found that it has a significant effect.

Therefore, a major advantage of incorporating these active agents into cosmetics is the reduction in the amount of active agent used.

For example, conventionally, 1.0% of solubilizer was used in cosmetics, but according to the present invention, the solubilizing power is equal to or higher than that of conventional products by using 0.5 to 0.6%. will be shown. Furthermore, as mentioned above, one of the features that greatly contributes to the quality of the synthetic products is that they are odorless.

This not only means that there is no odor as a cosmetic raw material, but also that it can be used to reduce the fragrance rate of fragrances used in products, or to be preferably used in odorless cosmetics. One of its characteristics is that it has the great advantage of reducing the cost of the product by reducing the amount used and the rate of flavoring. Next, regarding the decomposition stability against microorganisms described in item 5 above, it is also characterized by being extremely superior compared to conventional direct mirror polyoxyethylene alkyl ether type nonionic surfactants. It is. These do not unnecessarily increase the proliferation of harmful microorganisms that cause skin diseases,
In addition, it is possible to provide cosmetics that are effective for maintaining the hygiene of the skin layer and for beauty without being changed on the skin by microorganisms.

Regarding these points, we obtained the following results.

Experimental method: Dispense 30 volumes of the medium with the composition shown below into 100 desk-top shaker flasks, add the test substance to 1%, and sterilize by autoclaving at 120 qC for 20 minutes. After cooling, Pseudomonas no. 16 (bacteria) was inoculated and cultured under shaking conditions in good weather for 3,707 days, after which changes in dry bacterial weight and pH were measured. (Medium composition) Potassium phosphate 0.5g Potassium phosphate 2.5g Magnesium sulfate 0. Post ammonium sulfate 3. female sodium chloride
0.3g calcium carbonate (anhydrous) 0.3g or more of the medium composition is dissolved in 100ml of ion-exchanged water.

(Commercially available activator) A Polyoxyethylene (10) Euler alcohol ether B Polyoxyethylene (20) Euler alcohol ether (Activator according to the present invention) C Polyoxyethylene (20) 2-octyl dodecyl
Rare'Reko'Reate'ReD Polyoxyethylene (
25) 2-octyldodeci/rare'reko'reete'
Table 9: Degradability against bacteria As shown above, changes in bacterial weight and pH are observed for A and B, and C,
D was not recognized at all.

This means that compared to general commercially available surfactants, this active agent is less susceptible to bacteria resident on the skin or to bacteria that are contaminated during cosmetic use, and can be said to be a stable active agent. Also, if you summarize the safety tests for animals and humans in the last section, you will see the length of the first section.

The test substances are the following four types.

(Commercially available activator) A Polyoxyethylene (15) oleyl alcohol ether B Polyoxyethylene (20) oleyl alcohol/leate're (activator according to the present invention) C Polyoxyethylene (15) 2-octyldodecyl alcohol ether D Polyoxyethylene type (20)
2-Octyldodecyl alcohol ether Table 10 Animal safety test (*according to FDA method test) As shown in Section 1, primary animal skin irritation was low, and no acute oral toxicity was observed.

At the same time, Rapido conducted an eye soap irritation test (eyedra).
As a result of performing the izemethod), all of A to D were hypoallergenic.

In addition, as a safety measure for the human body, an occlusion patch test was conducted using a 1% aqueous solution for the above A to D, and the positive rate was low in all cases.

As mentioned above, it can be said that all of A to D are safe substances, but no significant difference was observed between A and B and C and D.

Next, a synthesis example will be shown.

Synthesis Example 2 - 1 mol of octyldodecyl alcohol (29 keys) and 0.04 mol% of caustic potassium as a catalyst were charged into an autoclave, and after replacing the air in the autoclave with dry nitrogen, the temperature was raised to 145 to 155 while praying on a rock. 0:00 Pressure: 3 to 5 k9/sat. Completely dissolve the catalyst.

Next, 15 moles of ethylene oxide (
66 female).

The temperature and pressure are maintained under the above conditions for 3 to 4 hours, and after the reaction is completed, aging is continued for 30 to 40 minutes.

After air cooling, take out from the reaction vessel and neutralize with dilute hydrochloric acid to pH 6-7.
Make it. In order to further remove the moisture contained, the pressure is reduced to 5~
1. Treat for about 30 minutes at a pH of 90 to 100 qo.

In order to remove the salt produced after treatment, the product is processed through a glass filter or a cloth filter. In addition to this,
5 ethylene oxide in 2-decyltetradecyl alcohol
By adding a nonionic surfactant in an amount of at least 1 mole, most preferably 15 to 23 moles, to a cosmetic base, a new irihoko agent could be obtained. Next, examples of the present invention will be shown.

(% is weight%) Example 1 I○ Light water 1 Glycerin 6.0%
2 Carpowax 1500 1
．． 03 Distilled water 75
．． 04 Ethyl alcohol 17
．． 05 Fragrance 0.
56 Drugs and preservatives Appropriate amount 7 Polyoxyethylene (15) 2-octyl dodecyl alcohol ether 0.55 - 7 ingredients dissolved in 4 transparently mixed with ingredients 1 - 3 mixed with light at room temperature Add while worshiping.

This is thoroughly milled with a rope punch and filled into a product. Example 2 Facial pack 1 Polyvinyl alcohol 8.0% 2
Ruboxymethylcellulose 6.03
Glycerin 604
Ethyl alcohol 6.05
Distilled water 73.0%6
Perfumery 0.57 Polyoxyethylene (20) 2-octyldodecyl alcohol ether 0.5 Among the above ingredients, add ingredients 2, 3, and 5, respectively, dissolve uniformly, and stir thoroughly.

This is called part A. Components 6 and 7 are added to 4 until the mixture becomes transparent, and then 1 is gradually added to the mixture to make it wet. This is called part B. Gradually add part B to part A, stir thoroughly until the mixture becomes uniformly transparent, filtrate, and fill to form a product.

Example 3 Hair Tonic 1 Ethyl alcohol 70.0%
2 Lanolin derivative 2.03
Fragrance 0.54 Polyoxyethylene (15) 2-octyldodecyl alcohol ether 0.55 Salicylic acid
Appropriate amount 6 vitamins &
〃7 Color material
〃8 Ion exchange water 2
7. Dissolve 2-7 in 1 and add to 8 while stirring at room temperature.

Claims (1)

[Claims] 1. As a solubilizer for poorly water-soluble fragrances, drugs, or oils in cosmetics that are made of water and alcohol as a base, and are made by adding and solubilizing fragrances, drugs, or oils that are sparingly soluble in water. -10 ethylene oxide in octyldodecyl alcohol
0.1 to 3 of the nonionic surfactant added with ~25 moles
．． A cosmetic characterized by containing 0% additive.