JPS6041979B2 - Method for producing aqueous suspension - Google Patents
Method for producing aqueous suspensionInfo
- Publication number
- JPS6041979B2 JPS6041979B2 JP911376A JP911376A JPS6041979B2 JP S6041979 B2 JPS6041979 B2 JP S6041979B2 JP 911376 A JP911376 A JP 911376A JP 911376 A JP911376 A JP 911376A JP S6041979 B2 JPS6041979 B2 JP S6041979B2
- Authority
- JP
- Japan
- Prior art keywords
- aqueous suspension
- zinc oxide
- producing aqueous
- aqueous solution
- producing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000007900 aqueous suspension Substances 0.000 title claims description 7
- 238000004519 manufacturing process Methods 0.000 title description 3
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 claims description 20
- 239000011787 zinc oxide Substances 0.000 claims description 10
- 239000003381 stabilizer Substances 0.000 claims description 3
- 238000000034 method Methods 0.000 claims description 2
- 239000011701 zinc Substances 0.000 claims description 2
- 229910052725 zinc Inorganic materials 0.000 claims description 2
- FGVVTMRZYROCTH-UHFFFAOYSA-N pyridine-2-thiol N-oxide Chemical compound [O-][N+]1=CC=CC=C1S FGVVTMRZYROCTH-UHFFFAOYSA-N 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 description 5
- -1 iron ions Chemical class 0.000 description 4
- 238000000354 decomposition reaction Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000002453 shampoo Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 description 2
- JZKFHQMONDVVNF-UHFFFAOYSA-N dodecyl sulfate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCCOS(O)(=O)=O JZKFHQMONDVVNF-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 229940031957 lauric acid diethanolamide Drugs 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- UWOVWIIOKHRNKU-UHFFFAOYSA-N 2,6-diphenyl-4-(2,4,6-triphenylpyridin-1-ium-1-yl)phenolate Chemical compound [O-]C1=C(C=2C=CC=CC=2)C=C([N+]=2C(=CC(=CC=2C=2C=CC=CC=2)C=2C=CC=CC=2)C=2C=CC=CC=2)C=C1C1=CC=CC=C1 UWOVWIIOKHRNKU-UHFFFAOYSA-N 0.000 description 1
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 description 1
- QKSBICQDOPKLQM-UHFFFAOYSA-N 2-[2-(2-hydroxyethoxy)ethoxy]ethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCOCCO QKSBICQDOPKLQM-UHFFFAOYSA-N 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 208000001840 Dandruff Diseases 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- UBNVDFUEPGQZQS-UHFFFAOYSA-N acetic acid;n,n-dimethyldodecan-1-amine Chemical compound CC([O-])=O.CCCCCCCCCCCC[NH+](C)C UBNVDFUEPGQZQS-UHFFFAOYSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- YKDMBTQVKVEMSA-UHFFFAOYSA-N diethylene glycol distearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCOCCOC(=O)CCCCCCCCCCCCCCCCC YKDMBTQVKVEMSA-UHFFFAOYSA-N 0.000 description 1
- 229940111071 diethylene glycol distearate Drugs 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 231100000567 intoxicating Toxicity 0.000 description 1
- 230000002673 intoxicating effect Effects 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
Landscapes
- Colloid Chemistry (AREA)
- Anti-Oxidant Or Stabilizer Compositions (AREA)
- Cosmetics (AREA)
Description
【発明の詳細な説明】
本発明は安定化された２−亜鉛ピリジンチオールー１−
オキシド（以下Ｚ−Ｐｔと略する）の水性懸濁液を製造
する方法に関するものである。DETAILED DESCRIPTION OF THE INVENTION The present invention provides stabilized 2-zinc pyridinethiol-1-
The present invention relates to a method for producing an aqueous suspension of oxide (hereinafter abbreviated as Z-Pt).
Ｚ−Ｐｔは強い抗菌性を有する事からフケ防止化粧料と
して知られている。しカルながらＺ−ｐｔは水に不溶性
の為その効果を充分に発揮させるには、皮膚との接触を
良くするよう微酔な粉末とし、又、副作用を防止する為
に速やかに除去しうるよう通常は界面活性剤を含有する
水性懸濁液としてシヤンプーの形で使用されている。と
ころがＺ−Ｐｔは乾燥状態、特に光を遮つた時は比較的
安定な白色の結晶状化合物であるが、微量な水分もしく
は光により分解し二硫化物を形成する性質がある。Z-Pt is known as an anti-dandruff cosmetic because it has strong antibacterial properties. However, since Z-pt is insoluble in water, in order to fully demonstrate its effects, it must be made into a slightly intoxicating powder to improve contact with the skin, and must be made into a powder that can be quickly removed to prevent side effects. It is usually used in shampoo form as an aqueous suspension containing a surfactant. However, although Z-Pt is a relatively stable white crystalline compound in a dry state, especially when shielded from light, it has the property of decomposing in the presence of trace amounts of moisture or light to form disulfide.
そしてこの生成物は黒色から炭紫色を呈し、時には特異
な入いを発する事がある。さらに又、Ｚ−Ｐｔは極微量
な鉄イオンの存在下において分解を早められる性質もあ
る。これらのＺ−Ｐｔの性質は水性懸濁液としてのシヤ
ンプーの製品価値をなくすばかりでなく頭髪を清浄なら
しめるシヤンプー自身の働きをも奪つてしまう。This product exhibits a color ranging from black to charcoal-purple, and may sometimes emit a peculiar tinge. Furthermore, Z-Pt has the property of accelerating its decomposition in the presence of a trace amount of iron ions. These properties of Z-Pt not only eliminate the product value of the shampoo as an aqueous suspension, but also deprive the shampoo of its own ability to cleanse the hair.
又、製造にあたつて極微量の鉄イオンの混入を防ぐ事も
非常に難しい。そこで上記の欠点を無くし安定したＺ−
Ｐｔの水性懸濁液を製造することを目的として研究の結
果、安定剤として酸化亜鉛を添加することによりＺ−ｐ
ｔを安定化させた水性懸濁液を得られることを見い出し
、本発明に達した。Furthermore, it is extremely difficult to prevent trace amounts of iron ions from being mixed in during manufacturing. Therefore, a stable Z-
As a result of research aimed at producing an aqueous suspension of Pt, it was found that by adding zinc oxide as a stabilizer, Z-p
It has been discovered that it is possible to obtain an aqueous suspension in which t is stabilized, and the present invention has been achieved.
先す実験結果により本発明を説明する。The present invention will be explained based on experimental results.
＜実験＞ 処方（２） ラウリル硫酸トリエタノールアミン ３５％水溶液 ・・・・・・１００』部 Ｚ−Ｐｔ・・・・・・２』部 酸化亜鉛 ゜’゜゛゜００・ ５部 処方（Ａ’） 前述処方（２）にて酸化亜鉛を無添加にしたもの。<Experiment> Prescription (2) Lauryl sulfate triethanolamine 35% aqueous solution 100 parts Z-Pt...2'' part Zinc oxide ゜’゜゛゜00・5 parts Prescription (A’) The above formulation (2) without the addition of zinc oxide.
処方（Ｂ）
アンヒトール２０Ｂ（花王石鹸株式会社製ラウリルジメ
チルアミン酢酸ベタイン
３０％水溶液） ・・・・・・１００』部Ｚ−Ｐｔ・・
・・・・２』部
酸化亜鉛 ・・・・・・０．５部
処方（Ｂ’）
前述処方（Ｂ）にて酸化亜鉛を無添加にしたもの。Prescription (B) Amhitol 20B (Kao Soap Co., Ltd. lauryl dimethylamine acetate betaine 30% aqueous solution) 100'' parts Z-Pt...
...2'' parts Zinc oxide ...0.5 parts Formula (B') The same as the above formulation (B) but without the addition of zinc oxide.
ＩＡ）、（Ａ’）、（Ｂ）、（Ｂ’）を透明ガラスピン
に入れ４ｌＣ恒温、屋外日光照射下、室内蛍光灯下の各
条件にて観察し、黒色から炭紫色となんらかの変化の生
じた時点を見た。IA), (A'), (B), and (B') were placed in a transparent glass pin and observed at 4lC constant temperature, outdoors under sunlight irradiation, and under indoor fluorescent light. I looked at the moment it happened.
上記表の如く酸化亜鉛添加の処方についてはＺ一Ｐｔの
分解による変化は見られない。As shown in the above table, no change due to the decomposition of Z-Pt is observed in the formulations in which zinc oxide is added.
次に製品としての実施例を説明する。Next, an example as a product will be described.
実施例 （イ）
ｚ−Ｐｔ・・・・２．０％
酸化亜鉛 ・・・・１．０％ラ
ウリン酸ジエタノールアミド ・・・・５．０％ラウ
リル硫酸トリエタノールアミン
（３５％水溶液）・ ・・５０．０％ジエチレングリコ
ールジステアレート
・・・・３．０％メチルセルロース
・・・・０．５％香料
・・・・０．５％水を加えて１００％とする。Example (a) z-Pt...2.0% Zinc oxide...1.0% Lauric acid diethanolamide...5.0% Lauryl sulfate triethanolamine
(35% aqueous solution)...50.0% diethylene glycol distearate
...3.0% methyl cellulose
...0.5% fragrance
...Add 0.5% water to make 100%.
実施例 （口）
ｚ−Ｐｔ・・２．０％
酸化亜鉛 ・・・・０．２％ト
リエチレングリコールモノステアレート
・・・・５．０％ポリオキ
シエチレンソルピタン モノオレエート（２０．
Ｅ．０）・・・・・０．１％ラウリルジメチルアミノ酢
酸 ベタイン（３０％水溶液）・・・・１０．
０％ポリオキシエチレンラウリルエーテル 硫酸ナトリ
ウム（３０％水溶液）・・・・４０．０％ラウリン酸ジ
エタノールアミド ・・５．０％ＥＤＴＡ・・・・
０．１％香料 ・・・・０
．５％水を加えて１００％とする。Example (mouth) z-Pt...2.0% Zinc oxide...0.2% triethylene glycol monostearate
...5.0% polyoxyethylene solpitan monooleate (20.
E. 0)...0.1% lauryldimethylaminoacetic acid betaine (30% aqueous solution)...10.
0% polyoxyethylene lauryl ether Sodium sulfate (30% aqueous solution)...40.0% Lauric acid diethanolamide...5.0% EDTA...
0.1% fragrance...0
．． Add 5% water to make 100%.
これら実施例による製品はジャンプーとして使用される
ものであり、大量の泡を発生するとともに、容易に洗い
落すことが出来る。The products according to these examples are used as jumpers, generate a large amount of foam, and can be easily washed off.
そして実施例（イ）および（口）を用いて前記実験と同
方法にて観察を行つた結果においてもｚ−Ｐｔの分解に
よる変化は見られなかつた。又、実施例（イ）および（
帽こついてはこれを試料として酸化還元滴定により直接
Ｚ−？を定量した結果、次表の数値が得られた。Also, no change due to the decomposition of z-Pt was observed in the results of observation using the same method as in the above experiment using Examples (a) and (x). In addition, Example (a) and (
If you are having trouble, use this as a sample and perform redox titration directly to determine Z-? As a result of quantification, the values shown in the following table were obtained.
以上の結果により、酸化亜鉛を安定剤として用いた場合
、水性懸濁液中のＺ−？が安定して分散されることが証
明される。Based on the above results, when zinc oxide is used as a stabilizer, Z-? is proven to be stably distributed.
Claims (1)
ジンチオール−１−オキシドを安定化する水性懸濁液の
製造方法。1. Process for producing an aqueous suspension for stabilizing 2-zinc pyridinethiol-1-oxide in the presence of zinc oxide as a stabilizer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP911376A JPS6041979B2 (en) | 1976-01-30 | 1976-01-30 | Method for producing aqueous suspension |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP911376A JPS6041979B2 (en) | 1976-01-30 | 1976-01-30 | Method for producing aqueous suspension |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5292881A JPS5292881A (en) | 1977-08-04 |
| JPS6041979B2 true JPS6041979B2 (en) | 1985-09-19 |
Family
ID=11711566
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP911376A Expired JPS6041979B2 (en) | 1976-01-30 | 1976-01-30 | Method for producing aqueous suspension |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6041979B2 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916947A (en) * | 1994-12-02 | 1999-06-29 | Cape Cod Research, Inc. | Zinc oxide photoactive antifoulant material |
| WO2000005961A1 (en) * | 1998-07-28 | 2000-02-10 | Nicca Chemical Co., Ltd. | Antibacterial and mildewproofing agents for fibers, antibacterial and mildewproofing processing method and antibacterial and mildewproofing fiber products |
| ATE424181T1 (en) * | 1999-06-25 | 2009-03-15 | Procter & Gamble | TOPICAL ANTIMICROBIAL COMPOSITIONS |
| ES2601463T3 (en) * | 2002-04-22 | 2017-02-15 | The Procter & Gamble Company | Compositions for personal hygiene comprising a zinc-containing material in an aqueous surfactant composition |
| US9381148B2 (en) | 2003-03-18 | 2016-07-05 | The Procter & Gamble Company | Composition comprising particulate zinc material with a high relative zinc lability |
| US9381382B2 (en) | 2002-06-04 | 2016-07-05 | The Procter & Gamble Company | Composition comprising a particulate zinc material, a pyrithione or a polyvalent metal salt of a pyrithione and a gel network |
| KR101091413B1 (en) | 2008-05-30 | 2011-12-07 | 유겐가이샤 와이에이치에스 | New crystalline pyrithione/zinc oxide composite and physiologic/antibiotic composition containing the same |
| DE102010043076A1 (en) * | 2010-10-28 | 2012-05-03 | Henkel Ag & Co. Kgaa | Active substance combination and hair treatment agent for dandruff II |
| CN112616848A (en) | 2013-11-19 | 2021-04-09 | 奥麒化工股份有限公司 | Enhanced preservatives |
| US11510854B2 (en) | 2017-03-23 | 2022-11-29 | Conopco, Inc. | Hair care composition |
| MX384296B (en) | 2017-04-26 | 2025-03-14 | Unilever Ip Holdings B V | Antidandruff hair care composition comprising pyrithione |
-
1976
- 1976-01-30 JP JP911376A patent/JPS6041979B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| JPS5292881A (en) | 1977-08-04 |
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