JPS604230B2 - New thickening agent - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a novel thickening agent that exhibits excellent thickening properties and thickening stability without toxicity and high safety.

In detail, the carboxyl type monomer is the main component, and the general formula (in the formula, R represents hydrogen or a methyl group, 1, m is ○
Indicates a number that satisfies <10m<35.

) and alkenyl ethers (hereinafter simply referred to as alkenyl ethers), particularly for use as a thickening agent for cosmetics and pharmaceuticals. The thickening agent here means used as a thickener, dispersion stabilizer, and emulsion stabilizer. Concentrated steel agents for cosmetics and pharmaceuticals include natural products such as vegetable rubber and cellulose derivatives, but they have the disadvantage of being uneven in quality and easily decomposed by microorganisms such as mold and bacteria, so recently they have become less popular. Synthetic polymers have come into use.

For example, there are vinyl alcohol, vinyl pyrrolidone, acrylic acid, and a copolymer of acrylic acid as a main component with allyl fructose (hereinafter abbreviated as allyl futose type). In particular, the allyl futose type has excellent thickening properties and thickening stability, and is widely used as a thickening agent.
However, the allyl futo sugar type produces formaldehyde during storage.

Although this is probably inactive to mold and bacteria, it is thought that formaldehyde is produced by the decomposition of the glycose group. When used, it is said that there is no problem with toxicity since it is used as a solution of several percent, but the generation of aldehyde even in small amounts is a serious problem when used in cosmetics and medicines that adhere to the human body. It's coming. While conducting research on concentrated rice preparations, the present inventors discovered a new concentrated rice preparation that has better properties than conventional ones and also solves the problem of formaldehyde production, which was a drawback of the allyl-recommended glycoform. This made it possible to provide steel agents.

That is, it is a copolymer of alkenyl ethers and carboxyl type monomers, and is used after being neutralized before use. The carboxyl type monomer is mainly acrylic acid, and is one type or a mixture of two or more types selected from the group consisting of olefinically unsaturated carboxylic acids such as methacrylic acid, itaconic acid, and chloroacrylic acid.

Alkenyl ethers are obtained by reacting the corresponding alkylene glycol, such as diethylene glycol, polyethylene glycol, polypropylene glycol, with allyl halide or meta-allyl halide in the presence of a strong alkali. Alkenyl ethers are about 0.0% of the total amount of monomers.
It is used in a range of 0.01% to 30%, preferably in a range of 0.1% to 5%.

This copolymer, which is the rice treatment agent of the present invention, is a white acidic fine powder,
Soluble in water, alcohols and glycols.

In use, the copolymer is dispersed at the desired concentration in the desired medium and neutralized, or the copolymer and the neutralizing agent are mixed and then the medium is added, or the medium containing the neutralizing agent is mixed. A copolymer may be added and mixed. As the neutralizing agent, common inorganic bases such as sodium hydroxide, potassium hydroxide, ammonium hydroxide, sodium carbonate, etc., or organic bases such as trimethylamine, triethylamine, dodecylamine, etc. are used. The neutralized copolymer thus obtained forms a neutral or slightly basic, transparent gel with an optimum viscosity, which varies depending on the specific composition of the medium to be thickened, but generally obtains the desired viscosity with an amount of 1% or less.

When the copolymer of the present invention is used as an agricultural and rice agent, it has superior properties compared to conventional products.

The properties of the copolymer of the present invention and a 0.2% aqueous solution of allyl futose type at pH 7 are shown below. Furthermore, the amount of formaldehyde produced is shown.

As mentioned above, the thickening agent of the present invention has excellent thickening properties and thickening stability, hardly any formaldehyde is generated, and the viscosity does not change due to temperature changes, making it suitable for use with ethanol and glycerin. affinity and many cosmetics,
Products that have a high degree of compatibility with raw materials commonly used in pharmaceuticals, and are used as thickening agents for cosmetics and pharmaceuticals, such as creams, ointments, lotions, and viscosity agents, and meet the demands of this industry. It is.

Examples will be described below in detail. In the examples, parts indicating numbers are parts by weight, and % indicates weight %. Example 1 (Production Example) 11.8 parts of acrylic acid monomer and 108 parts of benzene were placed in a reaction vessel equipped with a thermometer, a fly Azusa device, and a nitrogen gas introduction tube.
1 part, 0.006 parts of azobisisobutyronitrile, and 0.3 parts of polyethylene glycol bisallyl ether (average molecular weight of polyethylene glycol 200), and the mixture was heated at 45 to 5,000 °C for 1 hour in nitrogen gas. maintain.

Cool, dry and obtain white low density fine powder. Example 2 (Production Example) Alkenyl ether is converted into polypropylene glycol bisallyl ether (average molecular weight of polypropylene glycol: 150) and reacted and treated in the same manner as in Example 1 to obtain a white, low-density fine powder.

Example 3 (Formulation example) Cosmetic pack Distilled water 10 parts Copolymer obtained in Example 2 0.5 parts
1.2 parts of 10% sodium hydroxide, 5 parts
Adjust the pH to 7 by adding 7 parts of % sodium silicate.

This sticky sap contains 5 parts of glycerin, 2 parts of polyoxyethylene glycol nonyl phenyl ether, and 50 parts of female hormone.
Add the mixture of 01U/2 and stir evenly under reduced pressure if necessary to defoam to obtain a product. Example 4 (formulation example) Hand cream 70 parts of distilled water, 12 parts of glycerin, 1 part of the copolymer obtained in Example 1 was dispersed, 1 part of propanolamine was added, and the pH was adjusted to 7 to 8. do.

Add 5 parts of white pigment to this viscous liquid. In addition, 10 types of cetyl alcohol, 6 bases of lanolin, and 2 mineral spirits.
Add the above mixture and mix with a pestle to make the product. Example 5 (formulation example) Pharmaceutical cream lotion 10 parts of distilled water 0.2 parts of the copolymer obtained in Example 2
0.5 part of 10% sodium hydroxide is added to adjust the pH to 7-8.

This clay rice contains 8 parts of calamine, 8 parts of zinc oxide, and 4 parts of glycerin.
Add the ingredients, stir, and mix to make the product. Example 6 (Formulation example) Disperse 0.1 part of the copolymer obtained in Example 1 with 0.1 part of distilled water and 0.5 part of sodium carbonate. and adjust the pH to 7.

Claims (1)

[Claims] 1. A carboxyl type monomer, and about 0.0% of the monomer.
1% to 30% by weight General formula ▲ Numerical formulas, chemical formulas, tables, etc. are available ▼ (In the formula, R represents hydrogen or methyl group, 1, m is O<1
Indicates a number that satisfies +m<35. ) A new thickening agent whose active ingredient is a copolymer with alkenyl ether.