JPS6113443B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to an insecticide composition suitable for use as a shampoo or hair cleansing agent.
It is especially used to exterminate highly resistant insects such as lice and fleas. Various ingredients for exterminating these insects,
For example, DDT, hexachlorocyclohexane and lindane are known, but these substances are usually used in powder form and are dangerous to use in direct contact with human skin due to their high toxicity. Taking lice and fleas as an example, these pests prefer to attack young animals (children, puppies, kittens), which are particularly sensitive to toxins. On the other hand, it is also known that certain acid components, such as acetic acid, are effective in liquid form when used against insects and parasites, especially in concentrated solutions around pH 2. However, at such PH values these liquids are substantially harmful to the animal's skin and therefore have to be used in dilute solutions, resulting in a substantially reduced efficacy. The object of the present invention is to provide an insecticide composition that eliminates or reduces the above-mentioned disadvantages, and that can effectively exterminate insects and parasites and prevent them from returning to the treated area. That's true. Compositions of the invention particularly suitable for use as shampoos are those containing a humectant such as sodium lauryl sulfate, an ammonium compound or triethanolamine, and wherein the pH of the composition is 4.5.
1 to 25% by volume of at least one organic acid having 2 to 8 carbon atoms, preferably less than 3.5. In particular, the composition according to the invention may contain 2 to 12% by volume of acetic acid and 0.5 to 20%, especially 0.5 to 3%, of an insecticide, which insecticide can be applied to cloves, lavender, peppermint, honeysuckle, cornflowers, etc. , lime, juniper,
Natural substances or synthetics such as essences or extracts of lemon, citronella grass, citronella herbaceous, morning glory, pine, pyrethrum and essence oil of fruit peel and Ceylon leaves. It is obtained from matter. It is desirable that the compositions of the invention also contain from 1.5 to 5%, preferably from 0.5 to 1.5%, of an insecticide or therapeutic agent such as a natural or synthetic insecticide. In order to better understand the action and effectiveness of the compositions of the invention, examples of formulations for the main uses of the compositions, as well as processing methods, are described below, without limitation. It must be noted that in each formulation the proportion of wetting agent is important. In this regard, it is surprising that the insecticidal effect of acetic acid is significantly reduced by the use of wetting agents such as ammonium compounds, triethanolamine, sodium lauryl sulfate, traditional cationic bases or nonionic was found to increase with the addition of products. This finding was confirmed by the following tests performed on the little weasel, the ant, and the pincer beetle.
That is, the product used in the experimental examples described below was diluted to 1/3 of its volume and a few drops were placed onto each insect placed on an objective slide so as to immerse more than 3/4 of its body. It was written. The time it took for the insects to stop moving was then measured. This time was compared with the results using an aqueous solution of acetic acid with the same PH value. The results obtained showed on average 2-5 times less time than pure acetic acid (20-50 seconds instead of 1-3 minutes). Example 1 Hygienic shampoo for lice for adults and children The ratio is by volume. Texapant (R) N40 wetting agent (Henkel)
[Texapant(R) N40 (sodium lauryl sulfate) wetting agent HENKEL] Diluted to 30%
75-95% Synthetic lice 0.5-1.5% Citronella 0.5-1.5% Acetic acid 5-10% PH 1.8-2.3 (a) Hair of 11- and 13-year-olds with significant colonies of adult lice and eggs. He disposed of other people's children with shampoo. Ingredients of shampoo are 1% synthetic shampoo, 1% citronella essence.
%, Texapant® 93% diluted in acetic acid 5% and 30% (adjusted to pH 2.1). This shampoo treatment was carried out at 9 o'clock in the morning.
Shampoo treatment lasted for 15 minutes and was followed by washing with water. The test results showed that there were no adult lice.
It showed that the percentage of eggs decreased. Parts 2 and 4
After 6 days, further shampoo treatment was performed. The number of lice eggs decreased continuously. With weekly new washes, the eggs disappeared completely after 3 weeks. (b) It was discovered that a 15-year-old girl had lice while taking a bath. The girl was treated with 0.8% lindane powder every night. I was forced to wear a bonnet over my head at night, and every morning I was washed with regular shampoo and combed. 5
Days later, the eggs still remained in the girl's hair. As a result of one shampoo treatment with the product shown in (a), all parasites disappeared from the girl's hair. And now I don't have to continue with the troublesome and unpleasant process I had been dealing with. (c) A 5-year-old girl was infected with lice eggs for three weeks. and Linden 0.4% and DDT 10% every night
Processed with powder containing. The insecticide was protected in the girl's hair under the bonnet overnight. The girl was given the usual shampoo treatment and combing of her hair in the morning. This young girl had particularly fine hair, and many lice eggs were stuck to it. The first treatment with the product (a) was not sufficient and two more treatments were required to eliminate the eggs. Example 2 Treatment for fleas, lice, and ticks on dogs 6% acetic acid, 1.5% citronella, clove essence
Texapant(R) 91% diluted to 1.5% and 30%
(adjusted to pH 2) was used. An adult dog, Tetsukeru, was treated for a flea infestation. Washing with the shampoo prepared by the veterinarian was done at 8am. By 12 o'clock, the fleas were gone, and no fleas were present for the next three days, even under the filthy conditions. Tachijiya Kosou decoction 25%, apple wine vinegar 73%
Preservative treatment by spraying with a lotion solution containing 2% Citronella and 2% Citronella prevents the resurgence of the parasite until the environment (houses and textiles) has been completely purified with the product of Example 3 (Reference Example). did it. Example 3 Treatment of houses and textiles Shampoo consisting of 10% acetic acid, 2% citronella essence, and 2% syonno (prepared to pH 1.8)
was used. Fleas were found in a room that had not been used for some time and contained various poorly sealed items and textiles. After tidying up the items, shampoo diluted twice with water was sprinkled on the carpet and tile surfaces of the floor. After 2 hours, no fleas were observed to survive. Similarly, coats, blankets and dog baskets were treated with a solution of 5 cm ³ of shampoo in 1 part water with good results. In general, the method of using the products of the invention is as follows. The part to be treated is shampooed with the composition described above and is effective for a period of 1 to 10 minutes in the case of animals and 5 to 20 minutes in the case of articles. It is then washed many times to flush out acetic acid and other substances along with the parasites. It is known that insect control products remain in sufficient quantities even after cleaning to prevent new infestations. However, among a number of examples, continuous washing at certain intervals until the larvae have completely disappeared, and also preservation treatment in the form of a spray of various essences, preferably without acetic acid, are recommended. It is advantageous to do so. Namely, citronella grass, clove essence, lavender, honeysuckle, honeysuckle, lime, juniper, lemon,
The insecticide Essence from the essence oil of Chijiya Kosou, Shirobana Asagao, Asagao, Pyrethrum and Ceylon wick leaves is used.
Shiono may or may not be used. This spray protects the item during each shampoo treatment. Furthermore, the insecticidal action of the shampoo used in Example 1 (a) was compared with a powder formulation containing 15% lindane as follows. 1 Test against adult lice 5 cm ³ of pure shampoo were placed in a dish and 5 lice (pediculus humanus) were further placed there and died immediately. To check the results,
A further test was carried out in which the lice were left in shampoo for only 10 seconds. When I took it out with a wooden stick and looked at it with a magnifying glass, the lice were completely dead. The same test was performed with shampoo diluted to 50% and 25%, and concentrations from 25% to 100% were investigated. In the two dilutions, the death of the lice was delayed, and the lice recovery test showed that the lice could no longer survive after 30 seconds. The same test was performed on the species phtirius pubis and obtained 100% mortality after 30 seconds. These tests were compared to lindane 15% formulation powder. The table below summarizes the results. The same test was carried out on phtirius pubis adults with identical results. Tests on pediculus humanus adults

[Table] 2 Testing on eggs of pediculus humanus It was difficult to know whether the eggs were properly exterminated. 2-5 to confirm death
This is because you have to wait a week. The fact that the egg was separated from the hair to which it was attached
It could be done by destroying it. The following tests were conducted. Ten hairs with eggs on them were removed from the child and placed in a dish with the test product or water for 15 minutes and then stored at a temperature of 22°. Some of them came off the hair inside the shampoo, but others remained attached. Observations continued for over 5 weeks. The results were as follows. The same test was performed on eggs of phtirius pubis with identical results. Therefore, the product was more effective than the 15% lindane formulation. The 0.4 and 0.8% lindane formulations had comparatively insufficient efficacy.

Table: The microbiological action of the product of the invention was also confirmed, despite not containing anything like methyl paraoxybenzoate, which is commonly used as a disinfectant. As a result of various tests, it has been found that bacteria do not occur in pure or 50% diluted products. Because of the interest in the results obtained, a test was carried out to check whether the product was free of bacteria. The method used with the shampoo of Example 1 was as follows. (1) Inoculation of seeds into regular alimentary culture medium (2) Storage in dry cupboards at 37°C for 48 hours and 7 days

【table】

[Table] Other applications and modifications of the invention will be readily apparent to those skilled in the art without departing from the scope of the invention, in particular the substitution of the various products mentioned above with equivalent values; For example, it is known that replacing acetic acid with a homologous type of acid can be readily accomplished, but the results obtained are substantially inferior. This was especially true for propionic acid and caprylic acid. The measured toxicity varies substantially, and this reinforces the advantage of acetic acid working in conjunction with a humectant, reducing its toxicity completely within the range compatible with its use when in contact with sensitive epidermis. It increases the insecticidal power while maintaining the In this regard, P.
O.Toxicity is maximum allowable dose 24ml/Kg, 100 lethal dose 40ml/Kg
showed that. Although this result does not confirm the 50% lethal dose, for comparison the 50% lethal dose of lindane tested orally on rats in aqueous solution is approximately 300mg/Kg.
It is. Finally, skin local tolerance studies showed a low initial irritation factor of 0.3, and repeated application tests on rat ears showed the conclusion that the shampoo was not an irritant. Furthermore, repeated applications on rabbit skin showed excellent tolerability. Only tests involving the eye suggested the shampoo's potential as a stimulant, but this irritating effect is extremely weak when the product is used at the required dilution.

Claims (1)

[Scope of Claims] 1. In a non-irritating insecticide composition used in the form of shampoo or hair wash, 74-95% by volume of ammonium compounds, triethanolamine and sodium lauryl sulfate selected from the group consisting of: Wetting agent, 2-12% by volume of acetic acid and 0.5-3% by volume of clove, lavender, peppermint, honeysuckle,
Extracts or essences of pyrethrum, lime, eucalyptus, lemon, citronella grass, chimney, sardines, pine, pyrethrum and extracts of fruit peel or Ceylon lactis leaf. The insecticide composition as described above, comprising at least one natural or synthetic plant extract or essence selected from the group consisting of oils, and having a pH of less than 4.5. 2. The insecticide composition according to claim 1, comprising 0.5 to 3% by volume of citronella essence. 3. The insecticide composition according to claim 1, wherein the wetting agent is sodium lauryl sulfate.