JPS6158442B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a skin cosmetic composition that has a novel sebum secretion suppressing effect (action), and more specifically, it is safe for the skin, suppresses sebum secretion on the face, etc., prevents makeup from fading, and improves makeup retention. The present invention relates to a novel skin cosmetic composition. Lipids secreted on the skin surface (hereinafter referred to as sebum)
It maintains the homeostasis of living skin by maintaining appropriate flexibility and humidity of the stratum corneum, preventing and controlling the absorption of harmful substances from the outside world, and preventing bacterial and fungal infections. It plays an important function that is indispensable. however,
On the other hand, sebum is also the cause of makeup fading.
In other words, as will be described later, when the skin has been applied with make-up makeup, when the amount of sebum secreted increases, the so-called "shininess" will first occur, followed by "makeup floating", and so on.
“Color dullness,” “fading,” or “pigment twisting” becomes noticeable, and your makeup looks ruined. How makeup comes off varies greatly depending on the amount of sebum secreted by the user, and is particularly influenced by temperature, humidity, and amount of exercise, but in general, make-up starts to come off 2 to 3 hours after applying makeup during the daytime in summer. Become recognized. Therefore, almost all women who use make-up cosmetics have long desired the creation of cosmetics that do not easily come off and have long-lasting makeup. For this purpose, various researches have been conducted on the development of finishing cosmetic bases with excellent water resistance and the surface treatment of pigments, but nothing that is fully satisfactory has yet been obtained. The present inventors conducted extensive systematic research on the influence of sebum on makeup discoloration and the prevention of makeup discoloration, and found that (1) Generally, the area on the face with a large amount of sebum secretion is called the "T zone". , forehead, nose, nostrils,
The skin should be around the midline of the face, such as the chin. (2) Makeup fading also occurs and manifests significantly in this "T-zone." (3) The most effective way to prevent makeup from fading and make makeup last longer is to suppress sebum secretion on the cross-section. (4) Levulinic acid or its salts are safe when applied to the skin and can quickly exert the effect of suppressing sebum secretion, and these compounds
The present invention was completed based on the discovery that significant effects are exhibited in the low concentration range of 0.0001 to 0.04%. That is, the present invention provides a sebum secretion suppressing agent which is made by blending levulinic acid and/or its salts (hereinafter referred to as levulinic acid-based compounds for convenience) in an aqueous cosmetic base in an amount of 0.0001 to 0.04% by weight based on the total amount of prescription ingredients. It is a skin cosmetic composition with excellent effects. As the salt of levulinic acid in the present invention,
Preferred examples include alkanolamine salts such as ammonium salts and triethanolamine salts, alkali metal salts such as sodium salts and potassium salts, and alkaline earth metal salts such as calcium salts and magnesium salts. The amount of levulinic acid and/or its salt is 0.0001 to 0.04% by weight, preferably 0.001 to 0.04% by weight, based on the total amount of prescription ingredients (weight of the cosmetic composition).
It is 0.01% by weight. If it is less than 0.0001% by weight, the sebum secretion suppressing effect is low and it is difficult to obtain the effect of preventing makeup from fading, and if it exceeds 0.04% by weight, it may cause eye mucous membrane irritation if it comes into contact with the eyes, which is not preferable. In addition, West German Patent Publication No. 2436468 discloses a skin cosmetic for the purpose of moisturizing effect, which is characterized by containing a large amount (1 to 20% by weight) of levulinic acid. Concentrations may cause skin irritation and are not applicable to the cosmetic compositions of the present invention. Furthermore, there is no suggestion whatsoever about the effect of suppressing sebum secretion or the effect of preventing makeup from fading. In the present invention, as the aqueous cosmetic base in which the levulinic acid-based compound is blended, lotion-like bases and transparent gel-like cosmetic bases for skin cosmetics are particularly preferred, but the simplest ones are Water alone may also be used. The water content in the skin cosmetic composition of the present invention is usually 50 to 99% by weight. The amount of alcohol in the lotion base is at most 40% by weight based on the total amount of prescription ingredients.
Preferably it is 10 to 30% by weight. Other ingredients to be blended include fragrances, colorants, preservatives, and the like, as well as astringents, solubilizers, humectants, PH regulators, plant extracts, and the like, if necessary. The lotion-like skin cosmetic composition obtained according to the present invention is extremely safe without producing precipitates, discoloration, or odor even when stored for a long period of time, and does not irritate the skin when used and leaves a refreshing feeling on the skin. The effects of the levulinic acid compound are remarkable in that it has an excellent effect of inhibiting sebum secretion, prevents makeup from fading, and makes makeup last longer. In the base of a transparent gel cosmetic, the amount of alcohol added is at most 40% by weight, preferably 10 to 30% by weight, based on the total amount of prescription ingredients. A thickener made of a known polymeric substance such as carboxyvinyl polymer or hydroxypropyl cellulose is used as a base for transparent gel-like cosmetics. The amount incorporated is usually 0.1 to 1% by weight, preferably 0.2 to 0.5% by weight. Other ingredients to be blended include perfumes, colorants, preservatives, and the like, as well as astringents, solubilizers, humectants, PH regulators, plant extracts, and the like, if necessary. The transparent gel-like skin cosmetic composition obtained by the present invention is extremely stable without causing discoloration, odor, or opacity even after long-term storage, and does not cause skin irritation when used, giving a refreshing feeling to the skin. The levulinic acid compound has an excellent effect of suppressing sebum secretion, prevents makeup from fading, and makes makeup last longer.The action and effect of the levulinic acid compound is remarkable. In the skin cosmetic composition of the present invention, the levulinic acid compound and at least one organic polymer selected from the group consisting of zinc paraphenolsulfonate, allantoin chlorohydroxyl aluminum, allantoin dihydroxyl aluminum, and basic aluminum chloride are provided. a valent metal salt, or a 1,3-butylene glycol extract of at least one medicinal plant selected from the group consisting of burdock, mustard, evergreen ivy, and soapwort, or the levulinic acid-based compound and the organic polyvalent metal salt. When used in combination with the 1,3-butylene glycol extract of the medicinal plant, a better sebum suppressing effect and makeup smearing prevention effect can be obtained compared to when the levulinic acid compound is used alone. It is possible to further improve the makeup lingering effect. The above-mentioned organic polyvalent metal salts can be blended in one or in combination of two or more, and the blending amount thereof is at most 3.0% by weight, preferably 0.5-2.0% by weight, based on the total amount of prescription ingredients. be. The 1,3-butylene glycol extract of medicinal plants is prepared by extracting at least one medicinal plant selected from the group consisting of burdock, mustard, evergreen ivy, and soapwort using 1,3-butylene glycol or an aqueous solution thereof. This is an extracted version. The most preferred of these extracts is one obtained by extracting at least one of the above-mentioned medicinal plants with an aqueous solution of 1,3-butylene glycol. For example, for each 10 kg of burdock, mustard, everlasting ivy, and soapwort, for example, 40 kg
After adding 20% 1,3-butylene glycol aqueous solution and soaking at 20 to 25°C for 10 to 15 days, centrifugation is performed. Add 20% 1.3-butylene glycol aqueous solution to each residue and immerse and separate in the same manner. The medicinal plant extract may be blended into the base in the form of an extract, or may be blended in the form of an extract after 1,3-butylene glycol is appropriately distilled off. The amount to be incorporated into cosmetic compositions is at most 2.0% by weight per dry solid content, based on the total amount of prescription ingredients.
Preferably it is 0.1 to 1.0% by weight. The skin cosmetic composition of the present invention can be used on the face, especially in the T zone (foreign area) where sebum secretion is high, after removing sebum and dirt by washing or wiping the skin.
When applied in an appropriate amount to the nose, nostrils, chin, etc., the above-mentioned levulinic acid compounds, organic polyvalent metal salts, medicinal plant extracts, etc. have a mild effect on the skin, moderately suppress sebum secretion, and reduce skin irritation. Its unique effects include maintaining the crisp feel of bare skin for a long time, preventing the formation of shine and oil floatation, and preventing the makeup from fading due to make-up cosmetics, making makeup last noticeably better. The sex is remarkable. Examples of the present invention will be described below. In the examples, parts refer to parts by weight, and % refers to % by weight.
means. Example 1 (Lotion of the present invention) 15 parts of ethanol, 0.3 parts of polyoxyethylene lauryl ether (20E.O.) (solubilizer), 0.1 part of methylparaben, 0.1 part of fragrance, 1.0 part of glycerin, 0.01 part of vitamin A palmitate. A skin cosmetic composition of the present invention (a skin lotion having a sebum secretion suppressing effect) consisting of 83.48 parts of water and 0.01 part of the following levulinic acid or its salt was prepared in a conventional manner. For comparison, a control lotion was prepared in which only the levulinic acid compound was not added. The levulinic acid compounds used and their respective symbols shown in Tables 3 to 10 below are as follows. A: Levulinate B: Triethanolamine salt of levulinic acid C: Ammonium levulinate D: Sodium levulinate E: Calcium levulinate The sebum secretion inhibiting effect of each of the obtained lotions was evaluated by the following experiment. Method for measuring Γ sebum secretion inhibition rate The sebum on the foreheads of 8 to 16 subjects was thoroughly wiped off with absorbent cotton impregnated with 75% ethanol, and the whole body was divided into four parts. A different sample is applied to each of the three areas, and the other area is used as a control test without applying any sample. 1 hour, 2 hours and 3 hours after application
No. 6) for 30 seconds, the sebum secreted on the skin surface (recovery sebum) is adsorbed to the paper, and the method of Takaishi (Journal of the Japanese Dermatological Association, Vol. 70, P.433, 1960), the paper was blackened by exposing it to osmic acid vapor for 2 minutes.
After being exposed to air for an hour, the absorbance of the blackened paper is measured using a spectroscopic reflectometer, and the absorbance of the paper that does not absorb sebum is subtracted. The amount of recovered sebum in the control test area after 4 hours is taken as the saturated sebum amount, and the ratio of the amount of recovered sebum in each sample application area to the saturated sebum amount is determined from each absorbance, and the sebum secretion suppression rate is calculated using the following formula. do. Sebum secretion suppression rate (%) = 100 - Absorbance calculated from paper adsorbed with recovered sebum/Absorbance calculated from paper adsorbed saturated sebum x 100 The effect of preventing makeup from fading was evaluated by the following experiment. ΓMeasurement method for prevention of makeup deterioration A panel of 20 healthy women was tested at a temperature of 27.5~
The following tests were conducted in an environmental test room set at 28.5°C and humidity between 55% and 60%. (1) Acclimatize for 1 hour (2) Wipe away sebum from the entire face using cleansing cream. (3) Wipe off in the same way with Freshener and Cotton. (4) The forehead, nose, on either side of the left or right face,
A sample composition such as the cosmetic composition of the present invention is applied to areas that secrete a lot of sebum, mainly around the nostrils. Note that a cosmetic to which no levulinic acid compound was added was applied to the other side of the face as a control. (5) Apply a certain amount of the following foundation to the entire face. (6) 1, 2, and 3. The judge evaluates the state of makeup deterioration after each time. The formulation of the foundation used is as follows. Microwax 10 parts Vaseline 16 Isopropyl myristate 15 Polyoxyethylene cetyl ether (20E.O.
) 6 Antioxidant 0.06 Propylparaben 0.1 Fragrance 0.5 Titanium oxide 22.34 Talc 23.8 Iron oxide 1.5 Yellow ocher 4.1 Carbon black 0.6 Makeup discoloration and color of the present lotion and comparison lotion Tables 1 and 2 show the dullness and prevention effects.

【table】

【table】

【table】

[Table] Table 3 shows the quality characteristics and sebum secretion suppressing effects of the lotion of the present invention and the comparative lotion.

【table】

[Table] The appearance of lotions containing levulinic acid A and its salts B, C, D, and E, as well as lotions without the addition of levulinic acid.
Even after 6 months at 45°C or 6 months at 5°C, it remained as clear and colorless as it was immediately after production, and the odor remained good with no off-odor even after 6 months at 45°C. Sensory characteristic evaluation was carried out 3 hours after application, and the evaluation in Table 1 or Table 2 above was performed.
"The foundation remained intact." Or, "The color of the foundation did not fade." It is considered to be equivalent to From the sensory property data in Table 3, by blending levulinic acid or its salts, when the foundation is used, it becomes more durable (does not easily fall apart),
Furthermore, it was not clear that the dullness of color due to aging of the foundation was improved. As for the sebum secretion suppressing effect, as shown in Table 3, for all samples, the longer the time after application, the lower the sebum secretion suppressing rate, but the lotion containing levulinic acid or its salts The inhibition rate was clearly higher than that of the lotion without the addition of levulinic acid compounds (control), indicating that sebum secretion was inhibited. As a result of investigating the relationship between sebum secretion suppression rate and makeup deterioration, makeup deterioration was hardly observed when the sebum secretion suppression rate was 40% or higher. It was found that it became somewhat noticeable when the suppression rate was 30% or less, and became noticeable when the suppression rate was 10% or less. In other words, since there is a so-called threshold of sebum secretion for the appearance of makeup deterioration, if the sebum secretion suppression rate is above the threshold, even if the suppression rate differs depending on the applied sample, there will not be much difference in actual makeup deterioration. unacceptable. Example 2 The amount of levulinic acid was varied as shown in Table 4,
A lotion was prepared in the same manner as in Example 1 of the present invention, except that the amount of water used was varied so that the total amount of the formulation was 100 parts. The results are shown in Table 4. As is clear from the results in Table 4, the amount of levulinic acid used in the present invention is 0.0001 to 0.04% by weight based on the total amount of prescription ingredients. When the amount is less than 0.0001% by weight, the sebum secretion suppression rate (effect) and the effect of preventing makeup from fading will decrease.
Moreover, if it exceeds 0.04% by weight, eye mucosal irritation may occur, which is undesirable.

【table】

[Table] Example 3 In the same manner as in Example 1 of the present invention, except that levulinic acid was used as the levulinic acid compound and each of the organic polyvalent metal salts shown in Table 5 was used instead of glycerin. A lotion was prepared. As is clear from Table 5, when levulinic acid and an organic polyvalent metal salt selected from the group consisting of zinc paraphenolsulfonate, allantoin chlorohydroxy aluminum, allantoin dihydroxy aluminum, and basic aluminum chloride are combined, , the effect of suppressing sebum secretion is better than when organic polyvalent metal salts are not used together, and the foundation has better longevity (the foundation does not easily crumble), and the color of the foundation does not fade over time. A skin cosmetic composition with less blemish is obtained.

【table】

[Table] Example 4 The present invention of Example 1 except that levulinic acid was used as the levulinic acid-based compound, zinc paraphenolsulfonate was used instead of glycerin, and the blending amount was changed as shown in Table 6. A lotion was prepared in the same manner. The results are shown in Table 6. As is clear from the results in Table 6, the amount of zinc paraphenolsulfonate used is at most 3.0% by weight based on the total amount of prescription ingredients. When the amount exceeds 3.0% by weight, the transparency of the product tends to decrease, and it tends to give unfavorable results such as irritation of the eye mucous membranes.

【table】

[Table] Example 5 Levulinic acid was used as the levulinic acid compound, and 1,3-butylene glycol (1,3-
BG) A lotion was prepared in the same manner as in Example 1 of the present invention except that the extract was used. The results are shown in Table 7. As is clear from the results in Table 7, 1,3-butylene glycol extracts of medicinal plants selected from the group consisting of burdock, mustard, evergreen ivy, and soapwort are combined with levulinic acid (levulinic acid-based compounds).
When used together with, compared to when not used together,
To obtain a lotion that has a better effect of suppressing sebum secretion, has a better foundation retention (the foundation is less likely to crumble), and has less fading of the foundation color over time.

【table】

[Table] Example 6 Levulinic acid was used as a levulinic acid-based compound, 1,3-butylene glycol extract of burdock was used instead of glycerin, and the blending amount was adjusted to 8.
Example 1 except that the amount of water was changed as shown in the table and the amount of water was changed so that the total amount of prescription ingredients was 100 parts.
A lotion was prepared in the same manner as in the present invention. The results are shown in Table 8. As is clear from Table 8, 1,3-butylene glycol extract of burdock (1,3-BG extract)
The amount used is at most 2.0% by weight. If it exceeds 2.0% by weight, it is not preferable because the transparency of the product decreases and eye mucous membrane irritation occurs.

[Table] Example 7 Sodium levulinic acid was used as the levulinic acid compound, the amount of the compound was changed as shown in Table 9, and the amount of water used was changed so that the total amount of prescription ingredients was 100 parts. Each lotion was prepared in the same manner as in Example 1. The results are shown in Table 9. Similarly to the case of levulinic acid (Example 2), sodium levulinic acid also exhibited excellent sebum secretion inhibiting effects and makeup fading prevention effects within the range of 0.0001 to 0.04 weight.

[Table] Example 8 (Transparent gel-like skin cosmetic composition) 20 parts of ethanol, 0.1 part of fragrance, 3.0 parts of 1,3-butylene glycol, carboxyvinyl polymer
0.2 part, potassium hydroxide 0.01 part, 0.001 part of levulinic acid A or its salt shown in Table 10, appropriate amount of pigment, polyoxyethylene hydrogenated castor oil (60E.O)
A transparent gel-like skin cosmetic having a composition of 0.2 parts was prepared by a conventional method. The results are shown in Table 10. As is clear from the results in Table 10, even when levulinic acid A or its salts B, C, D, and E are blended into a transparent gel-like base, there is no effect when blended with a lotion base (Example 1). Similarly, it exhibits an excellent sebum secretion suppressing effect and an effect of preventing makeup from fading.

【table】

Claims (1)

[Claims] 1. Levulinic acid and/or its salts are added to an aqueous cosmetic base in an amount of 0.0001% based on the total amount of prescription ingredients.
A skin cosmetic composition with an excellent sebum secretion suppressing effect, containing ~0.04% by weight. 2. The skin cosmetic composition according to claim 1, wherein levulinic acid and/or its salt is blended in an amount of 0.001 to 0.01% by weight based on the total amount of prescription ingredients. 3. The skin cosmetic composition according to claim 1, wherein the salt of levulinic acid is an ammonium salt, an alkali metal salt, an alkaline earth metal salt, or an alkanolamine salt of levulinic acid. 4. Furthermore, at least one organic polyvalent metal salt selected from the group consisting of zinc paraphenolsulfonate, allantoin chloroaluminum, allantoin dihydroxyaluminum, and basic aluminum chloride in an amount of at most 3.0% by weight based on the total amount of prescription ingredients. A dermocosmetic composition according to claim 1, in which the composition is formulated. 5. Furthermore, at least 1,3-butylene glycol extract of at least one medicinal plant selected from the group consisting of burdock, mustard, evergreen ivy, and saberweed is included in an amount of at most 2.0% by weight per dry solid content based on the total amount of prescription ingredients. A skin cosmetic composition according to claim 1. 6. The skin cosmetic composition according to claim 1, wherein the aqueous cosmetic base is a base for a lotion-like cosmetic or a transparent gel-like cosmetic.