JPS6216927B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to an oral composition that has an excellent preventive and suppressive effect on oral odor, and in particular, suppresses the ability of Fusobacterium to generate methyl mercaptan, which causes the development of oral odor, and has a good oral odor-preventing effect. In addition to the effects of preventing cavities and periodontal diseases, the desired properties of conventional toothpaste include cosmetic effects such as whitening teeth, preventing oral odor, etc.
Masking was desired. In particular, oral odor prevention, removal, and masking have conventionally relied on masking with fragrance ingredients and sterilization of microorganisms with cationic disinfectants. In this case, masking by the fragrance ingredients does not suppress the occurrence of oral odor itself, but rather the fragrance ingredients sensually eliminate the bad odor, or the pleasant sensation in the oral cavity causes the oral odor to be removed. It only gave a feeling and did not provide a basic solution. In addition, the method using cationic disinfectants has an excellent oral odor suppressing effect when viewed simply from the masking effect of the fragrance, but it is effective against thickly formed dental plaque containing many anaerobic bacteria that have strong oral odor production. The effect was not sufficiently exerted on the tongue, tongue coating, and even the back of the oral cavity, and this point was not satisfactory. Furthermore, examples of oral compositions containing N-long chain alkylyl sarcosine and/or its salts include Japanese Patent Publication No. 45-24480, Japanese Patent Publication No. 52-47022,
JP-A-52-57338, JP-A-52-79036, JP-A-54-
11242, JP-A-53-121947, and JP-A-52-
Listed in 79037. In particular, in Japanese Patent Publication No. 45-24480, the properties of various alkylyl groups were investigated. However, it is clearly stated here that sodium N-lauroyl sarcosinate is less effective in inhibiting the growth of harmful microorganisms in the oral cavity than other compounds having an alkyl group. Despite the above-mentioned known examples, as a result of various studies on various compounds, the present inventors found N-long chain alkylyl sarcosine and/or N-long chain alkylyl sarcosine containing 90 to 95.5% by weight of a lauroyl group in which the alkyl group has 12 carbon atoms. Or, the salt acts on Fusobacterium, etc., which causes oral odor, and suppresses the generation of methyl mercaptan, which causes oral odor, and has excellent permeability and thickly formed dental plaque. The present invention was made based on the discovery that it works well on the inner part of the oral cavity as well. The present invention will be explained in more detail below. The present invention provides an oral composition containing a flavoring agent, a sweetening ingredient, a surfactant, and, if necessary, water, a wetting agent, a binder, and an abrasive. ~99.5% by weight of N
- It is characterized by containing long-chain acyl sarcosine and/or its salt, and as an oral preparation, it can be used in normal forms such as toothpaste and mouthwash. By using chain acyl sarcosine, we suppress the activity of Fusobacterium, a bacteria that causes bad breath that is abundant in the back of the mouth.
It prevents and suppresses the occurrence of bad breath. Here, as the N-long chain alkylyl sarcosine and/or its salt, an alkali metal, particularly a sodium salt is preferably used. The constituent alkylyl groups are 90 to 99.5% by weight of lauroyl groups having 12 carbon atoms, while other alkylyl groups include 0.1 to 5% by weight of decanoyl groups and 0.1 to 5% by weight of myristoyl groups. base, 0
It consists of ~2% by weight of palmitoyl groups. In addition, the amount of N-long chain alkylyl sarcosine and/or its salt is 0.1 to 0.1 to 1.
The content is preferably 1% by weight. In this case, if it is less than 0.1% by weight, it will have poor halitosis suppressing power, and if it is more than 1.0% by weight, it may cause peeling of the mucous membrane in the oral cavity or impair the feel of toothpaste, such as the texture of the mouth. The composition of the present invention contains a surfactant other than the above-mentioned N long-chain alkyl sarcosine, and the surfactant may include nonionic,
Anionic, amphoteric surfactants, etc. can be blended. Examples of nonionic surfactants include fatty acid esters of sugars or sugar alcohols, such as fatty acid residues with a carbon number of 12 to 18 and an average degree of esterification of 1.1 to 1.
2.5, more preferably 1.2 to 1.9 sucrose fatty acid ester, maltose fatty acid ester, maltol fatty acid ester, maltotriitol fatty acid ester, maltoteslytol fatty acid ester, maltopentitol fatty acid ester, maltohexitol fatty acid ester, malt Hexitol fatty acid ester, maltoheptitol fatty acid ester, sorbitan fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester, etc., and polyoxyethylene sorbitan fatty acid ester such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monostearate, etc. In addition to polyoxyethylene fatty acid esters such as polyoxyethylene hydrogenated castor oil, fatty acid diethanolamides such as lauric acid mono- or diethanolamide,
Fatty acid monoglycerides, polyoxyethylene higher alcohol ethers, polyoxyethylene polyoxypropylene copolymers, polyoxyethylene polyoxypropylene fatty acid esters, and the like may also be used. Examples of anionic surfactants include water-soluble salts of higher alkyl sulfates whose alkyl group has 8 to 18 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate, α-olefin sulfonate, sodium lauryl monoglyceride sulfonate, and sodium lauryl monoglyceride sulfonate. Water-soluble salts of higher fatty acid monoglyceride sulfonates whose fatty acid group has 10 to 18 carbon atoms such as sodium coconut monoglyceride sulfonate, higher fatty acid sodium monoglyceride monosulfate, sodium-N-methyl-N-palmitoyl tauride, sodium- Examples include N-lauroylo-β-alanine, sodium-N-long chain acyl basic amino acid, and the like. Furthermore, as amphoteric surfactants, 2-alkyl-
Examples include N-erboxymethyl-N-hydroxyethylimidazolinium betaine, alkyldiaminoethylglycine hydrochloride, and lauryldimethylaminoacetic acid betaine. Note that these surfactants may be used alone or in combination of two or more. In addition, the amount of surfactant added is usually 0.01 to 5 of the total amount.
%, more preferably 0.05 to 3%. In the present invention, it is particularly preferable to use sodium lauryl sulfate, which is highly effective against Fusobacterium, such as sodium alkyl sulfate, in order to improve foaming power. Furthermore, it is desirable to add acylamide, gelatin, polyoxyethylene hydrogenated castor oil, etc. for the purpose of improving the irritation caused by these surfactants during tooth brushing. The oral composition of the present invention further includes menthol,
Carvone, anethole, eugenol, methyl salicylate, limonene, ocimene, n-decyl alcohol, citronellol, α-terpineol,
Methyl acetate, citronellyl acetate, methyl eugenol, cineole, linalool, ethyl linalool, vanillin, thymol, spearmint oil, peppermint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla Flavoring agents such as oil, wintergreen oil, clove oil, eucalyptus oil, etc. alone or in combination can be added to the total amount of 0.1~
In addition, sweeteners such as saccharin sodium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilaritin, thaumatin, asparatyl phenylalanine methyl ester, p-methoxycinnamic aldehyde, etc. can be blended at 10%, preferably 0.5 to 5%. agent (0.01~1
%, preferably 0.05 to 0.5%). In addition to the above-mentioned components, the oral composition of the present invention may further contain appropriate components depending on the purpose, type of composition, etc. For example, in the case of pasty compositions such as ointments, binders include carrageenan, cellulose derivatives such as sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, and sodium carboxymethylhydroxyethylcellulose, alkali metal alginates such as sodium alginate, and propylene glycol alginate. Gums such as ester, xanthan gum, tragacanth gum, karaya gum, gum arabic, synthetic binders such as polyvinyl alcohol, sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, inorganic binders such as silica gel, aluminum silica gel, vegum, laponite, etc. One or more of these may be blended (the blending amount is usually 0.3 to 5%). Furthermore, in the production of pasty or liquid oral compositions, sorbitol, glycerin,
ethylene glycol, propylene glycol,
One or more types of 1,3-butylene glycol, polyethylene glycol, polypropylene glycol, xyrite, maltite, lactite, etc. may be blended (the blending amount is usually 10 to 70%). Or, in the case of toothpaste, dibasic calcium phosphate dihydrate and anhydride, dibasic calcium phosphate, dibasic calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina, silicic anhydride, silica gel, aluminum silicate. , insoluble sodium metaphosphate, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, synthetic resins, etc. (compounding amount usually 20 to 90%). %, in the case of toothpaste, 5% to 60%). In addition, sterilized water may be added depending on each case. (Usually 5 to 95%) In this case, in one embodiment, a so-called transparent or translucent toothpaste can be obtained by using a silica-based abrasive. To adjust these transparent toothpastes, as a silica-based abrasive,
−91994, 49−94712, 50−64198, 50−65497, 51
Using silica-based abrasives described in -128695, 51-136841 and Japanese Patent Publication No. 54-4919, etc., the refractive index of these silica-based abrasives, a viscosity agent, and a refractive index of a transparent dispersion containing water as the main components were calculated. It can be obtained by bringing it closer.
Furthermore, if necessary, titanium oxide, α-alumina, dibasic calcium phosphate anhydride, etc. may be added in view of the appearance problem of transparency. In addition, in the present invention, the active ingredients further include enzymes such as dextranase, amylase, protease, mutanase, lysozyme, and lytic enzyme (Litetsu enzyme), and alkali metals such as sodium monofluorophosphate and potassium monofluorophosphate. Fluorides such as monofluorophosphate, sodium fluoride, and stannous fluoride, tranexamic acid and epsilon aminocaproic acid, aluminum chlorohydroxylalantoin, dihydrocholesterol, glycyrrhizin salts, glycyrrhetinic acid, glycerophosphate, chlorophyll, sodium chloride, calopeftide , monosodium glutamate, amino acids such as alanine, and water-soluble inorganic phosphoric acid compounds. Next, experimental examples will be shown to specifically explain the effects of the present invention. Experimental example 1 Halitosis-producing bacteria (Fusobacterium, Nucleatum) isolated from Researcher A's oral cavity were precultured using the usual method, collected, and brought to a predetermined concentration in 3 ml of 0.1M phosphate buffer. A certain amount of methionine and various active agents shown in Table 1 were added thereto at a concentration of 0.01%. This was allowed to react for 3 minutes, and the amount of methyl mercaptan generated was measured by gas chromatography. The results are shown in Table 1, where the inhibition rate is expressed by the following formula, where A is the amount generated when no activator is added, and B is the amount generated when the activator is added. (1-B/A)×100(%)

[Table] As is clear from the results in Table 1, 90 to 99.5% by weight of lauroyl groups with 12 carbon atoms in the constituent alkylyl groups.
Containing N-long chain alkylyl sarcosine and/or
Or its salts favorably inhibit the production of methyl mercaptan by Fusobacterium nucleatum, which is the main cause of oral odor development. Experimental Example 2 A toothpaste having the following composition was prepared, and its permeability was measured as follows. First, a 1.5 cm x 1.5 cm piece of thick fabric was cultured in a BHI medium containing sucrose together with the plaque-forming bacterium Streptococcus cumutans at 37°C for 48 hours to form plaque on the fabric. This was taken out and dried by heating to create artificial dental plaque. Next, the artificial plaque was floated on a dispersion of the toothpaste (37°C) diluted with 5 times the amount of water, and the time until the start of sedimentation was measured, and the results shown in Table 2 were obtained. (Toothpaste composition) Dicalcium phosphate 45 60% sorbitol 30 Silicic anhydride 2 Na-CMC 1 Saccharin/flavor 1.0 Na-lauryl sulfate (SDS) The amount shown in Table 2 N-long chain alkyl sarcosinate salt (sarcosinate) ) Quantity of water shown in Table 2 Remaining total 100

【table】

[Table] From the above results, it was found that the product of the present invention has good permeability, acts well on dental plaque in the oral cavity, and quickly acts on the deep parts of the oral cavity. . Examples are shown below. Example 1 Toothpaste Parts by weight Dicalcium phosphate dihydrate 45 VitaSeal 2 60% Sorbit 30 Sodium lauryl sulfate 1.5 Lauroyl sarcosine sodium salt (C ₁₂ ;
96.2, C ₁₄ ; 2.8, C ₁₀ ; 1.0) 0.3 Sodium saccharin 0.1 Na-CMC 1 Peppermint fragrance 0.8 Water 19.3 Example 2 Transparent toothpaste Part by weight Precipitated silica 20 Glycerin 10 60% sorbitol 45 Sodium lauryl sulfate 1.3 Lauroyl salt Cosine sodium salt (C ₁₂ ;
99.1, C ₁₀ ; 0.3, C ₁₄ ; 0.6) Satucharin sodium 0.13 CMC-Na salt 0.8 Peppermint flavoring 1.0 Water 21.47 Example 3 Toothpaste Part by weight α-alumina trihydrate 50 60% sorbitol 30 Sodium lauryl sulfate 1.2 Lauroyl Sarcosine sodium salt (C ₁₂ ;
98.8, C ₈ ; 0.1, C ₁₄ ; 0.5, C ₁₀ ; 0.4, C ₁₆ ; 0.2)
0.5 Satucharin Na salt 0.1 Na-CMC 0.9 Accented peppermint fragrance 0.8 Water 16.4 Example 4 Mouthwash Parts by weight Ethanol 20 Glycerin 10 Tween80 1 Lauroylsarcosine sodium salt (same composition as Example 3) 0.3 Contains menthol Fruit flavoring 0.3 Satucalin sodium 0.1 Zinc chloride 0.2 Water 68.1

Claims (1)

[Scope of Claims] 1. An oral composition containing a flavoring agent, a sweetening ingredient, a surfactant, and, if necessary, water, a wetting agent, a binder, and an abrasive;
N containing 90 to 99.5% by weight of 12 lauroyl groups and 0.5 to 10% by weight of one or a mixture of two or more of alkylyl groups having 8, 10, 14, and 16 carbon atoms.
- An oral composition comprising a mixture of long-chain alkylyl sarcosine and/or a salt thereof. 2. The oral composition according to claim 1, wherein the amount of N-long chain alkylyl sarcosine and/or its salt is 0.1 to 1% by weight. 3. The oral composition according to claim 1, which contains sodium alkyl sulfate as a surfactant.