JPS6221322B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a toothpaste composition that exhibits little change in appearance (transparency) due to temperature changes and has approximately the same transparency over a wide temperature range.

Conventionally, transparent or translucent toothpaste compositions use a silica-based abrasive as an abrasive, which is kneaded into a transparent vehicle containing water, a thickening agent, a binder, a surfactant, etc. Manufactured by In this case, the transparent vehicle is prepared to have substantially the same refractive index as the silica-based abrasive used, and the refractive index of the silica-based abrasive and the refractive index of the transparent vehicle are matched. In this case, a toothpaste composition with high transparency can be obtained.

However, the refractive index of a silica-based abrasive hardly changes with temperature, whereas the refractive index of a transparent vehicle changes significantly with temperature. Even if a highly transparent toothpaste composition is prepared by matching the refractive index of When the refractive index of the transparent vehicle changes and becomes significantly different from the refractive index of the silica-based abrasive, the transparency decreases, resulting in a toothpaste composition that does not have the desired transparency. It was hot.

As described above, the transparency of conventional transparent or translucent toothpaste compositions changes with temperature changes, and the change in appearance is noticeable to the user.
This is not desirable as a product, and a solution to this problem is required.

In view of the above circumstances, the present inventors have conducted intensive studies on toothpaste compositions that exhibit little change in transparency even when the temperature changes, and have found that the difference in refractive index is 0.005 to 0.05 as a silica-based abrasive. Two types of silica-based abrasives with different refractive indexes in a weight ratio of 20:80 to 80:20.
and the refractive index of the two types of silica-based abrasives as a transparent vehicle are α and α, respectively.
β (α<β), and the blending ratio is a:b
By using a toothpaste composition with a refractive index of α+b/a+b×(β-α), the transparency of the obtained toothpaste composition has little variation over a wide temperature range and remains almost constant even when the temperature changes. It was discovered that a certain level of transparency was maintained, and this led to the present invention.

The present invention will be explained in more detail below.

The present invention provides a toothpaste composition comprising a silica-based abrasive, a viscosity agent, a caking agent, and a transparent vehicle containing water as main components. 2 with different refractive index
Separate silica-based abrasives are used in a weight ratio of 20:80 to 80:20, and the above-mentioned silica-based abrasives are used as a transparent vehicle.
The refractive index of the seed silica-based abrasive is α and β, respectively.
(α<β), and the refractive index is α+b/a+b×(β−α) when the weight ratio is a:b.

Here, hydrated amorphous silica can be used as the silica-based abrasive. Examples of hydrated amorphous silica include precipitated silica, silica xerogel, silica aerogel, etc., but precipitated silica is particularly preferably used, and SiO ₂ content of 70% or more, preferably 90% or more, alkali/alkaline earth Metal oxide content 0~
5%, binding amount of metal oxides such as aluminum, magnesium, calcium, etc. to SiO _{2 0-10}
%, preferably 0-5%, adhering moisture content (loss on drying) 1-10%, average particle size 0.5-30μ, more preferably 1-15μ, specific surface area per gram (BET method) ^500m2 or less. , more preferably 300 m ² or less, a refractive index of 1.44 to 1.47, and a liquid absorption amount of 0.6 to 1.3 cc/g. in particular,
Zeo49, Zeodent113 from Huber in the US, WR in the US
Grace's Syloid AL-1, 63, 74, 404, UK J.
Neosyl ET from Crossfield & Sons, Germany
Examples include Sident 3 and 20 from Degussa.

In the present invention, two kinds of silica-based abrasives having different refractive indexes are used as the above-mentioned silica-based abrasives. In this case, these silica-based abrasives are
It is selected and used so that the refractive index is in the range of 1.430 to 1.465, and the difference in the refractive index is in the range of 0.005 to 0.05, especially 0.005 to 0.02, and thereby it has transparency and its transparency It is possible to reliably obtain a toothpaste composition that shows little change due to temperature.

The total blending amount of the silica-based abrasive is 1 to 40% (weight%, same hereinafter) of the entire toothpaste composition, especially 5 to 30%.
%, but in this case, the silica-based abrasives having different refractive indexes have a weight ratio of 20:80.
It is preferably contained in a ratio of ~80:20, particularly 40:60 ~ 60:40, and most preferably, two types of silica-based abrasives are contained in equal weight amounts.

Furthermore, it is preferable that the silica-based abrasives have the same minimum turbidity. In this case, the minimum turbidity means that a mixed solution with a refractive index of 1.435 to 1.471 (20°C) is prepared by mixing glycerin and water in various proportions, and silica-based polishing is added at a concentration of 10% by weight. The lowest turbidity value obtained by measuring the turbidity of each product in which the agent is dispersed.

Further, the transparent vehicle used in the toothpaste composition is prepared using water, a thickening agent, and a caking agent as main ingredients.

In this case, the thickening agent can be one or more of glycerin, sorbitol, polyethylene glycol, ethylene glycol, propylene glycol, reduced starch saccharide, xylitol, etc. 80%, preferably 40-75%.

In addition, binders include carrageenan, seaweed extract, cellulose derivatives such as sodium carboxymethyl cellulose, alkali metal alginates such as sodium alginate, gums such as xanthan gum, and synthetic binders such as polyvinyl alcohol, carboxyvinyl polymer, and polyvinylpyrrolidone. , amorphous igneous silica, and inorganic binders such as Ve-gum, etc., may be generally blended in an amount of 0.1 to 5% of the total toothpaste.

The transparent vehicle may optionally contain water-soluble salts of higher alkyl sulfates whose alkyl group has 8 to 18 carbon atoms, such as sodium lauryl sulfate and sodium myristyl sulfate, α-olefin sulfonate, and sodium lauryl monoglyceride sulfonate. , sodium coconut monoglyceride sulfonate, etc., where the fatty acid group has 10 to 18 carbon atoms.
Water-soluble salt of higher fatty acid monoglyceride sulfonate, higher fatty acid sodium monoglyceride monosulfate, sodium-N-methyl-N
- Anion activators such as palmitoyl tauride, sodium N-lauroyl sarcosinate, sodium N-lauroyl-β-alanine, sodium N-long chain acylamino acids, fatty acids with 10 to 16 carbon atoms
Approximately 60 moles of sucrose fatty acid ester, lactose fatty acid ester, lactitol fatty acid ester, maltitol fatty acid ester, ethylene glycol in which the fatty acid group has 12 to 18 carbon atoms such as fatty acid diethanolamide, stearyl monoglyceride, sucrose mono- and dilaurate, etc. Contains one or more surfactants such as nonionic surfactants such as added sorbitan monostearate condensates, polymers of ethylene oxide and propylene oxide, and derivatives such as polyoxyethylene polyoxypropylene monolauryl ester. In addition, essential oils such as peppermint and spearmint, flavoring materials such as l-menthol, carvone, eugenol, and anethole may be blended singly or in combination, and saccharin sodium, stevioside, neohesperidyl dihydro Chalcone, glycyrrhizin, perilartin, p-
Sweeteners such as methoxycinnamic aldehyde,
Preservatives such as sodium dihydroacetate, p-hydroxymethylbenzoic acid, p-hydroxybutylbenzoic acid, titanium dioxide, etc.
Other ingredients may be included.

Furthermore, the transparent vehicle contains active ingredients such as enzymes such as dextranase, amylase, protease, mutanase, phosphatase, lysozyme, and litetsuenzyme, and alkali metal monofluorophosphants such as sodium monofluorophosphate and potassium monofluorophosphate. ate, sodium fluoride, fluorine compounds such as stannous fluoride, stannous compounds such as stannous pyrophosphate, chlorhexidine salts such as chlorhexidine hydrochloride, chlorhexidine gluconate, sodium copper chlorophyllin, hinokitiol, epsilon aminocaprone. Acid, tranexamic acid, ethanedihydroxydiphosphonate, allantoin chlorhydroxyaluminum, dihydrocholesterol, glycyrrhetinic acid, crude drugs such as azulene, chamomile, chelating phosphoric acid compounds such as chlorophyll, glycerophosphate, sodium chloride,
One or more water-soluble inorganic phosphoric acid compounds may be blended.

In addition, in addition to the silica-based abrasive, an abrasive that tends to reduce transparency may be additionally blended in the present invention, but in that case, the blending amount is 10%.
Hereinafter, the amount is more preferably 10% or less based on the total amount of silica-based abrasive. Such additional abrasives include dibasic calcium phosphate, insoluble sodium metaphosphate, aluminum hydroxide, polymethyl methacrylate, and the like.

In the present invention, a transparent vehicle is prepared by appropriately selecting the above-mentioned components. In this case, the transparent vehicle has two types of silica-based abrasives with refractive indexes α and β (α<β). When used in a weight ratio of a:b, the refractive index of the transparent vehicle is adjusted to substantially correspond to the value α+b/a+b×(β−α). Thereby, the transparency of the toothpaste composition can be maintained substantially constant over a wide temperature range.

The refractive index of the transparent vehicle depends on the components used,
In particular, by changing the type and amount of the thickening agent, an appropriate value can be obtained.

As mentioned above, the toothpaste composition of the present invention has a refractive index difference of 0.005 to 0.005 as a silica-based abrasive.
Two types of silica-based abrasives having different refractive indexes of 0.05 are used at a weight ratio of 20:80 to 80:20, and the refractive index of the two types of silica-based abrasives is set to α as a transparent vehicle. , β (α<β),
By using a material whose refractive index is α+b/a+b×(β-α) when the weight ratio is a:b, even if the refractive index of the transparent vehicle changes due to temperature, the toothpaste composition There is little change in the transparency of the entire object.

That is, FIG. 1 shows this, and the graph in FIG. 1 shows the relationship between silica-based abrasive A with refractive index α, silica-based abrasive B with refractive index β, and silica-based abrasive with refractive index α. A constant temperature of a toothpaste composition obtained by adding a transparent vehicle with a different refractive index to a mixed abrasive C having an average refractive index γ (γ=α+β/2) in which an equivalent amount of a silica-based abrasive of β is used. This shows the turbidity change at (25℃). As shown here, when a single silica-based abrasive is used, a toothpaste composition with low turbidity and high transparency can be obtained in that the refractive index of the silica-based abrasive matches that of the transparent vehicle. As the difference between the refractive index of the silica-based abrasive and the transparent vehicle increases, the toothpaste composition becomes more cloudy and its transparency decreases (toothpaste composition using one type of silica-based abrasive). In the case of things,
If the difference between the refractive index of the silica-based abrasive and the refractive index of the transparent vehicle changes by more than 0.002, the appearance will change). On the other hand, when a mixed silica-based abrasive with an average refractive index γ is used, there is little change in the turbidity of the toothpaste composition, even if a transparent vehicle with a considerable difference in refractive index from this refractive index γ is used. Therefore, by adjusting the refractive index of the transparent vehicle to γ or around it, a toothpaste composition with little change in transparency can be obtained even if the refractive index of the transparent vehicle changes and the difference from γ becomes large. It is something.

Thus, according to the toothpaste composition of the present invention,
The refractive index of a transparent vehicle changes depending on the temperature, but even if the refractive index of the transparent vehicle changes, the transparency of the composition changes little. is 0
Transparency remains almost constant over a wide temperature range of ~40°C.

EXAMPLES Hereinafter, the present invention will be specifically explained by showing Examples and Comparative Examples.

Examples and Comparative Examples Two types of silica-based abrasives with refractive indexes of 1.438 and 1.448 shown in the following formulation (both have an average particle size of 5μ, BET
A toothpaste (example) containing a transparent vehicle having a refractive index of 1.443 at ²⁵ ° C. and a silica-based abrasive having a refractive index of 1.448 at 25° C. A toothpaste (comparative example) containing a transparent vehicle with a refractive index of 1.448 at 25°C was prepared.

Prescription silica-based abrasive 25% Sodium carboxymethyl cellulose 1.0 Sodium lauryl sulfate 1.2 Glycerin 5.0 Sorbit (70% aqueous solution) 50 Polyethylene glycol 400 5.0% Fragrance 1.2 Disinfectants, etc. 0.8 Water Remaining 100.0% Next, the transparency of the above toothpaste was 5. Measurements were made at temperatures of ℃, 25℃, and 40℃, respectively. The results are shown in Figure 2. In FIG. 2, the solid line is the toothpaste of the example, and the double line is the toothpaste of the comparative example.

The method for measuring transparency is as follows.

Toothpaste was filled into a glass outer cylinder to avoid air bubbles. Two 40W fluorescent lamps were placed in a frosted glass container as a light source, a glass plate with two light-opaque black lines drawn in parallel was placed on top of it, and toothpaste was placed on top of the glass outer cylinder. put Insert the inner tube from above and press the toothpaste to change the layer thickness, and the transparency is defined as the thickness in cm that allows the two black lines to be discerned.

[Brief explanation of the drawing]

Figure 1 is a graph showing the relationship between vehicle and turbidity when silica-based abrasives with different refractive indexes are added alone or as a mixture to a transparent vehicle. Figure 2 is a graph showing the relationship between silica-based abrasives with different refractive indexes It is a graph showing the relationship between temperature and transparency of toothpaste compositions using abrasives alone or in combination.

Claims (1)

[Scope of Claims] 1. In a toothpaste composition comprising a silica-based abrasive and a transparent vehicle mainly composed of a thickening agent, a binder and water, the silica-based abrasive has a difference in refractive index.
Two types of silica-based abrasives having different refractive indexes of 0.005 to 0.05 are used in a weight ratio of 20:80 to 80:20, and the refractive index of the two types of silica-based abrasives is used as a transparent vehicle. α, β (α<
β) and whose refractive index is α+b/a+b×(β-α) when the weight ratio is a:b. 2. The toothpaste composition according to claim 1, wherein the amount of the silica-based abrasive is 1 to 50% by weight. 3 Two types of silica-based abrasives at a weight ratio of 40:60 ~
Claim 1 used in a ratio of 60:40
The toothpaste composition according to item 1 or 2.