JPS6235778B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a disposable container package particularly adapted for use as a dispensing device. This is a two unit package with a liquid containing bottle and an open drug capsule.

The goal of bronchiectasis treatment is to reduce abnormally high airway resistance, which is most often achieved by administration of adrenergic drugs, including isoproterenol, phenylephrine, racemic epinephrine, and ephedrine. . Generally, these drugs are given as an aerosol in a powered nebulizer or intermittent positive pressure breathing device (IPPB). The usual dose is 1:
0.5-1.0 ml of 200 isopterenor or 2.25% racemic epinephrine diluted in sufficient saline or water (2-5 ml) to give aerosol treatment for 5-10 minutes.

Many hospitals utilize a multi-dose method of IPPB drugs, in which multi-dose vials of sterile saline or water are dropped off at the drug station by a specialist. A defined amount of liquid is then withdrawn from the multi-dose vial using a pre-sterilized disposable syringe. The liquid is drawn from the container into a syringe and then expressed into a nebulizer container.
Active ingredients, such as isoprotenol, broncosol, are added to the container by a metering dropper with a drug bottle, or withdrawn from the drug bottle by a single sterile syringe. In any case, the same bottles are passed from patient room to patient room, increasing the possibility of contamination and interference with sterility.

The aim of the invention is to eliminate the possibility of contamination of the aerosol solution.

Another object of the present invention is to provide a novel drug delivery device in which the parts of the drug delivery device are arranged in a novel and rapid manner to facilitate the delivery of bronchodilator solution into the nebulizer container of an IPPB device. The goal is to provide the following.

Another object of the present invention is to provide a new transparent graduated bottle that can accommodate changing physician prescriptions.

Another object of the invention is to automatically mix the medicament contained in the capsule with a diluent liquid contained in a transparent graduated bottle, with complete dosing in the desired direction;
Another object of the present invention is to provide a new drug-containing capsule in which the drug inside is completely washed out during the administration operation.

Another object of the invention is to provide a novel liquid-containing bottle designed to be easily opened with one hand and the neck of the bottle tightly attached to the capsule of the invention to complete the drug administration package. That's true.

Another object of the invention is to provide a new drug delivery device that is practical and efficient in construction and operation and that can be easily and economically manufactured.

Other objects of the invention will become apparent from the description of the embodiments shown in the drawings.

The molded deformable bottle 10 of the present invention has a generally oval cross-sectional shape and carries a downwardly extending tab 11 on which a control number, expiration date and other information can be written. ing. The bottle also has a scale 18 by which the amount of liquid passing through the capillary opening of the offset neck at the top of the bottle is measured.

The opening of the bottle is sealed by a lid closure seal 13 having a lever arm 14 and a flat circular cover 19.

The neck is offset from the central axis of the bottle such that one shoulder of the bottle is longer than the other, and this long shoulder forms a downwardly tapered shoulder 12. The taper increases the gap between the bottle and the lever arm so that when the bottle is held in one hand, the user's thumb can be inserted into this gap and by rotating the lever arm in the direction of the arrow, The lid is torn off and the top discarded. The sealed neck connection is molded so that the second sealing ring 36 is exposed when the lid closure seal is removed.

The neck of the bottle is molded with a plurality of ribs 16 which strengthen the neck and assist in guiding the capsule 30 over the neck of the bottle. The cylindrical portion 15 adjacent the bottle is adapted to be in frictional contact with the inner surface of the capsule to form a first seal 37.

The capsule 30 has a capping device 32 that seals both ends of the tube.
It is a hollow cylindrical tube 31 having a diameter. These closures are stoppers adapted to extend into the tube to form a central cavity 34 with a volume equal to the desired amount of active ingredient, as shown in Figure 3A. Alternatively, capsule 3
0, the cavity 35 is under vacuum and sealed by a cap 33 and stopper with a surface 33a adapted to be pierced by a hypodermic needle, as shown in FIG. 3B. In this example,
Physicians can prepare active ingredients other than those listed, inject them, and store them in the capsule until needed.

In use, a bottle containing a pre-measured amount of diluent, such as water or saline, is held in one hand by the physician, and the physician's thumb is placed on the tapered shoulder.
2 and the lever arm 14 and the top of the lid is removed and discarded. Liquid remains in the bottle because the inner diameter of the neck forms a capillary tube and the diluent needs to be crushed to crush the bottle.

The physician then removes one of the capsule's seals and positions the open end in the neck of the bottle to form a frictional engagement. first and second seals 3 formed by frictional contact between the neck and the capsule;
7, 36 prevents loss of liquid. By simply removing the remaining seal from the capsule, the unit is inverted, the bottle is squeezed out, and the contents within the capsule are transferred to IPPB by the diluent within the bottle.
injected into the nebulizer.

Although preferred embodiments have been described above, it is clear that the present invention is not limited thereto and can be modified and modified in various ways.

[Brief explanation of the drawing]

1 is a front view of a liquid container dosing bottle, FIG. 2 is a side view of the bottle of FIG. 1, FIG. 3A is a perspective view of a drug-containing capsule according to the invention, and FIG. 3B is a view of 3A. Figure 4 showing the deformation of the capsule shown in Figure 4.
The figure is a cross-sectional view of the capsule of FIG. 3A or 3B attached to the neck of the bottle of FIG. 1. 10...bottle, 11...tab, 13...lid closing seal,
14...Arm, 15...Cylindrical part of neck, 18...Scale, 30...Capsule.

Claims (1)

[Scope of Claims] 1. A capsule comprising a hollow cylindrical tube open at both ends and a removable lid device for sealing both ends of the tube, and containing a pharmaceutical active substance; A container containing a receptive liquid, which is a deformable molded bottle having a hollow neck, the neck comprising a cylindrical part extending outward from the lower part of the neck, and an upper end of the neck. a sealing ring formed in the hollow cylindrical tube, the sealing ring and the cylindrical portion forming a liquid-tight connection with the hollow cylindrical tube when the neck is inserted into the hollow cylindrical tube of the capsule. a bottle having an outer diameter that forms a frictional engagement; a flat circular cover breakably molded onto the sealing ring; and an outwardly extending lever integrally molded with the flat circular cover. 1. A drug administration device comprising: an arm; and a container provided with an arm. 2. A drug delivery device according to claim 1, wherein the closure device extends into the interior of the hollow cylindrical tube to form a central cavity with a volume equal to the desired volume of active substance. A drug administration device. 3. A drug administration device according to claim 1, wherein the lid device is a cup having a surface adapted to be pierced by a syringe needle. 4. The drug administration device according to claim 1, wherein the bottle is substantially oval in cross section, one shoulder of the bottle is longer than the other shoulder, and the bottle and the lever arm are connected to each other. The drug dispensing device wherein the neck is offset from the central axis of the bottle so as to form a space between the necks. 5. The drug administration device according to claim 1 or 4, wherein the bottle has a scale for measuring the amount of liquid that has passed through the opening of the neck. 6. The drug administration device according to claim 1 or 4, wherein the bottle has a tab extending downward from the bottom of the bottle.