JPS6323979B2 - - Google Patents
Info
- Publication number
- JPS6323979B2 JPS6323979B2 JP55069512A JP6951280A JPS6323979B2 JP S6323979 B2 JPS6323979 B2 JP S6323979B2 JP 55069512 A JP55069512 A JP 55069512A JP 6951280 A JP6951280 A JP 6951280A JP S6323979 B2 JPS6323979 B2 JP S6323979B2
- Authority
- JP
- Japan
- Prior art keywords
- bis
- benzoin
- terephthalaldehyde
- isophthalaldehyde
- benzaldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 claims description 53
- 229960002130 benzoin Drugs 0.000 claims description 42
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 claims description 26
- KUCOHFSKRZZVRO-UHFFFAOYSA-N terephthalaldehyde Chemical compound O=CC1=CC=C(C=O)C=C1 KUCOHFSKRZZVRO-UHFFFAOYSA-N 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 18
- -1 alkali metal cyanide Chemical class 0.000 claims description 15
- 239000002904 solvent Substances 0.000 claims description 15
- 229910052783 alkali metal Inorganic materials 0.000 claims description 13
- IZALUMVGBVKPJD-UHFFFAOYSA-N benzene-1,3-dicarbaldehyde Chemical compound O=CC1=CC=CC(C=O)=C1 IZALUMVGBVKPJD-UHFFFAOYSA-N 0.000 claims description 12
- NNFCIKHAZHQZJG-UHFFFAOYSA-N potassium cyanide Chemical group [K+].N#[C-] NNFCIKHAZHQZJG-UHFFFAOYSA-N 0.000 claims description 12
- 239000012429 reaction media Substances 0.000 claims description 6
- PAWQVTBBRAZDMG-UHFFFAOYSA-N 2-(3-bromo-2-fluorophenyl)acetic acid Chemical compound OC(=O)CC1=CC=CC(Br)=C1F PAWQVTBBRAZDMG-UHFFFAOYSA-N 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000007800 oxidant agent Substances 0.000 claims description 3
- FUEGWHHUYNHBNI-UHFFFAOYSA-N 1-[4-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-1,2-dione Chemical compound C=1C=CC=CC=1C(=O)C(=O)C(C=C1)=CC=C1C(=O)C(=O)C1=CC=CC=C1 FUEGWHHUYNHBNI-UHFFFAOYSA-N 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- OPQARKPSCNTWTJ-UHFFFAOYSA-L copper(ii) acetate Chemical compound [Cu+2].CC([O-])=O.CC([O-])=O OPQARKPSCNTWTJ-UHFFFAOYSA-L 0.000 claims description 2
- 230000001590 oxidative effect Effects 0.000 claims description 2
- DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 claims 1
- MARUZFTYOSSTHV-UHFFFAOYSA-N 1-[2-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-1,2-dione Chemical compound C=1C=CC=CC=1C(=O)C(=O)C1=CC=CC=C1C(=O)C(=O)C1=CC=CC=C1 MARUZFTYOSSTHV-UHFFFAOYSA-N 0.000 claims 1
- JXFFIJCCFUQFQC-UHFFFAOYSA-N 1-[3-(2-oxo-2-phenylacetyl)phenyl]-2-phenylethane-1,2-dione Chemical compound C=1C=CC=CC=1C(=O)C(=O)C(C=1)=CC=CC=1C(=O)C(=O)C1=CC=CC=C1 JXFFIJCCFUQFQC-UHFFFAOYSA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 description 26
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 18
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 15
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 description 12
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- 150000001875 compounds Chemical class 0.000 description 10
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 description 9
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 description 9
- 238000007193 benzoin condensation reaction Methods 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- 230000003647 oxidation Effects 0.000 description 7
- 238000007254 oxidation reaction Methods 0.000 description 7
- 239000002244 precipitate Substances 0.000 description 7
- 238000010992 reflux Methods 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 239000012071 phase Substances 0.000 description 6
- 239000000376 reactant Substances 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 244000028419 Styrax benzoin Species 0.000 description 5
- 235000000126 Styrax benzoin Nutrition 0.000 description 5
- 235000008411 Sumatra benzointree Nutrition 0.000 description 5
- 125000003118 aryl group Chemical group 0.000 description 5
- 235000019382 gum benzoic Nutrition 0.000 description 5
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 description 5
- 239000007795 chemical reaction product Substances 0.000 description 4
- 238000009833 condensation Methods 0.000 description 4
- 230000005494 condensation Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000012074 organic phase Substances 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 150000001299 aldehydes Chemical class 0.000 description 3
- 238000004587 chromatography analysis Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000001914 filtration Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000003960 organic solvent Substances 0.000 description 3
- 238000005481 NMR spectroscopy Methods 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 239000008346 aqueous phase Substances 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- WURBFLDFSFBTLW-UHFFFAOYSA-N benzil Chemical compound C=1C=CC=CC=1C(=O)C(=O)C1=CC=CC=C1 WURBFLDFSFBTLW-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000009835 boiling Methods 0.000 description 2
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 239000012043 crude product Substances 0.000 description 2
- WFPZPJSADLPSON-UHFFFAOYSA-N dinitrogen tetraoxide Chemical compound [O-][N+](=O)[N+]([O-])=O WFPZPJSADLPSON-UHFFFAOYSA-N 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 238000002844 melting Methods 0.000 description 2
- 230000008018 melting Effects 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000006068 polycondensation reaction Methods 0.000 description 2
- 238000011403 purification operation Methods 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 238000004809 thin layer chromatography Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical group N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 1
- 229910052684 Cerium Inorganic materials 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 238000004566 IR spectroscopy Methods 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 206010039737 Scratch Diseases 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 150000003934 aromatic aldehydes Chemical class 0.000 description 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 description 1
- 150000001555 benzenes Chemical class 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- ZMIGMASIKSOYAM-UHFFFAOYSA-N cerium Chemical compound [Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce][Ce] ZMIGMASIKSOYAM-UHFFFAOYSA-N 0.000 description 1
- 239000007810 chemical reaction solvent Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910052804 chromium Inorganic materials 0.000 description 1
- 239000011651 chromium Substances 0.000 description 1
- 238000006482 condensation reaction Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- NQFNBCXYXGZSPI-UHFFFAOYSA-L copper;diacetate;dihydrate Chemical compound O.O.[Cu+2].CC([O-])=O.CC([O-])=O NQFNBCXYXGZSPI-UHFFFAOYSA-L 0.000 description 1
- 125000005594 diketone group Chemical group 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- XKBGEWXEAPTVCK-UHFFFAOYSA-M methyltrioctylammonium chloride Chemical compound [Cl-].CCCCCCCC[N+](C)(CCCCCCCC)CCCCCCCC XKBGEWXEAPTVCK-UHFFFAOYSA-M 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000012452 mother liquor Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 150000004714 phosphonium salts Chemical group 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 150000003333 secondary alcohols Chemical group 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000007086 side reaction Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000001308 synthesis method Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000000870 ultraviolet spectroscopy Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00Â -Â C08G71/00
- C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
- C08G73/0683—Polycondensates containing six-membered rings, condensed with other rings, with nitrogen atoms as the only ring hetero atoms
- C08G73/0694—Polycondensates containing six-membered rings, condensed with other rings, with nitrogen atoms as the only ring hetero atoms with only two nitrogen atoms in the ring, e.g. polyquinoxalines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/296—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with lead derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
- C07C45/298—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with manganese derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
- C07C49/784—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic with all keto groups bound to a non-condensed ring
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G6/00—Condensation polymers of aldehydes or ketones only
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
æ¬çºæã¯ããã«ããšãã«ããããµãªã³æš¹èã®ã®
補é ã«ãããã¢ãããŒã§ããïŒïŒïŒâãã¹â
ïŒïŒããšãã«ã°ãªãªãã·ãã€ã«ïŒãã³ãŒã³åã³ïŒïŒ
ïŒâãã¹âïŒããšãã«ã°ãªãªãã·ãã€ã«ïŒãã³ãŒ
ã³ã®æ¹è¯åææ³ã«é¢ããã çŸåšã®æè¡æ°Žæºã«ãããŠã¯ãããªããšãã«ãã
ããµãªã³æš¹èã¯èç±æ§ãé žååã³ååŠè¬åã«å¯Ÿã
ãæµæåãšãã€ãç¹æã®ç¹æ§ãæããŠããããã
ã®äœ¿çšã®æ®åã«ã¯åºçºåæããã¢ãããŒå°±äžè³éŠ
æãã¹âαâãžã±ãã³ã®é«ãäŸ¡æ Œãé害ã«ãªã€ãŠ
ããããšãç¥ãããŠããããããã®ååç©ã®åæ
åå¿ã¯ãäºå®ãçšæã§é«äŸ¡ãªåå¿äœã®åãåãå€
æ°ã®äžéå·¥çšãå¿ èŠãšããã è³éŠæαâãžã±ãã³ãžã®æè¯ã®æ¥è¿æ³ã¯ããã³
ãŸã€ã³ãšåŒã°ãã察å¿ã®Î±âã±ãã¢ã«ã³ãŒã«ã®é ž
åã§ããããšããŸãç¥ãããŠãããäžè¬ã«ãã³ãŸ
ã€ã³ã¯ãïŒçš®ä¹è³æ°çš®ã®è³éŠæã¢ã«ãããããå
åŠéè«éããé¥ãã«å°ãªãéã§çšãããã¢ã«ã«ãª
éå±ã®ã·ã¢ã³åç©ã®ååšäžã«ãããŠçž®åããããŠ
補é ãããããšããã§ããã¬ãã¿ã«ã¢ã«ããããš
ãã³ãºã¢ã«ãããã®æ··åãã³ãŸã€ã³çž®åã«ãã€ãŠ
ã¯ãæåŸ ãããã¹âãã³ãŸã€ã³ãçããªãããšã
æè¿ç€ºãããïŒKratzer et coll.ïŒJ.Org.Chem.ïŒ
41ïŒ1976ïŒïŒ2230ïŒããã®ååç©ãåŸãã«ã¯ãå ã
ãã¬ãã¿ã«ã¢ã«ãããã®ãã¹éäºç¡«é žä»å ç©ã補
é ãã次ãã§ãããïŒã¢ã«ã®ã·ã¢ã³åã«ãªãŠã ãš
åå¿ããããŠãã¹âãã¬ãã¿ã«ã·ã¢ã³ãããªã³ã
åæããããã«ããã倧éå°ã®ãã³ãºã¢ã«ããã
ãšçž®åããããããšãå¿ èŠã§ãã€ãããã®æ¹æ³
ã¯ããã³ãŸã€ã³çž®åã«æ¯ããŠã倧éã®ã·ã¢ã³åã«
ãªãŠã ã䜿çšããããå€ãã®å¥ã ã®åå¿å·¥çšãèŠ
ãããšããäžéœåã瀺ãããšãããã€ãŠããã ããçš®ã®æ確ãªæ¡ä»¶äžã«ãããŠã¯ãäžæ¹ã«ãã
ãŠãã³ãºã¢ã«ããããšãä»æ¹ã«ãããŠãã¬ãã¿ã«
ã¢ã«ãããåã³ã€ãœãã¿ã«ã¢ã«ãããã®éã®æ··å
ãã³ãŸã€ã³çž®ååå¿ã®å®æœãå¯èœã§ããããšãèŠ
åºãããâããããŠãããæ¬çºæã®ç®çã§ããã
ãã®æ¡ä»¶äžã«ãããŠã¯ãåŸããããã¹âãã³ãŸã€
ã³ã¯99ïŒ ä»¥äžã®çŽåºŠãæããããã察å¿ãããã¹
âαâãžã±ãã³ã«é žåããåã«ç²Ÿè£œããå¿ èŠããª
ãããšããŸãèŠåºããããããæ ã«ããã®åŸè ã®
ååç©ã¯ãã®ãŸãŸæè¬ãããªããŒåãçŽåºŠãããª
ãã¡99ïŒ ä»¥äžã®çŽåºŠãæããŠããã æ¬çºæã®æ¹æ³ã«ããã°ãå ã第äžã«ãäžèšã®åŒ ãããã¯äžèšã®åŒ ã«çžåœãããã¹âãã³ãŸã€ã³ã補é ããã ãã®ããã«ã¯ãäžè¬çã«ã¯ãäžèšã®åŠã確å®ã
ãé£ç¶æäœãè¡ããããªãã¡ (a) ãã¬ãã¿ã«ã¢ã«ããããŸãã¯ã€ãœãã¿ã«ã¢ã«
ããããããã¬âïŒãŸãã¯ã€ãœâïŒãã¿ã«ã¢ã«
ãããã溶解ãåŸãããæ±ãããã¹âãã³ãŸã€
ã³ã溶解ããªã溶åªäžã«ãããŠããã¬âïŒãŸã
ã¯ã€ãœâïŒãã¿ã«ã¢ã«ãããïŒã¢ã«ã«å¯ŸããŠïŒ
ã¢ã«ãšããååŠéè«éããäœãå²åã®ã¢ã«ã«ãª
éå±ã·ã¢ã³åç©ãšåå¿ããããã (b) ãã¬âïŒãŸãã¯ã€ãœâïŒãã¿ã«ã¢ã«ãããïŒ
ã¢ã«ã«å¯ŸãïŒã¢ã«ãšããååŠéè«éã«å¯ŸããŠé
å°ã®ãã³ãºã¢ã«ãããïŒäžè¬ã«3.5ãïŒã¢ã«ïŒ
ã圢æããåå¿åªè³ªãåå¿ããããããã®å·¥çš
(b)ã¯å®€æž©ãäŸãã°çŽïŒã30âã«è¿ã枩床ã«ãã
ãŠå®æœããã次ãã§ã (c) åå¿åªè³ªãçŽ50ã150âã®æž©åºŠãäžè¬ã«ã¯æº¶
åªã®éæµæž©åºŠã«å ç±ããã ãã®æ¹æ³ã«ãã€ãŠããã¹âãã³ãŸã€ã³ã¯é«åç
åã³é«çŽåºŠã以ãŠåŸãããšãã§ããã çšããæäœæ¡ä»¶ã®éžå®ã®éèŠæ§ãäŸç€ºãããã
ã«ãæ··åãã³ãŸã€ã³çž®åã®æ©æ§ãäžèšã®åŠãåå¿
ã·ãŒã±ã³ã¹ã以ãŠèª¬æããããšã«ããã ã¢ã«ã«ãªéå±ã®ã·ã¢ã³åç©ã¯è³éŠæãžã¢ã«ãã
ãïŒã¢ã«ã«ã€ãïŒã¢ã«ãšããå²åããé¥ãã«å°é
ã§åªè³ªäžã«ã€ãååšããŠããã®ã§ããã¹âãã³ãŸ
ã€ã³ã®åçã¯ãåãã³ãŸã€ã³ãçãããããã³ãº
ã¢ã«ãããèªèº«ãžã®çž®åãããªãã¡ã ããã㯠åã®ããªãã³ãŸã€ã³ãçãããžã¢ã«ãããèªèº«ãž
ã®çž®åãæ倧éã«åé¿ããã°ãããã ãé«ããªã
ããšã«ãªãã ãããã®åå¿åã³ãã®ä»ã®å¯æ¬¡çãªåå¿ã¯ãé
åžžã®æ¡ä»¶äžã«ãããŠã¯ããã³ãºã¢ã«ãããã®ãã¬
ãã¿ã«ã¢ã«ããããŸãã€ãœãã¿ã«ã¢ã«ããããšã®
æ··åãã³ãŸã€ã³çž®åããäž»ãšããŠã¿ãŒã«ãšæ¥µããŠ
å°éã®ãã¹âãã³ãŸã€ã³ãçããããã ããã«åããŠãæ¬çºæã®æäœæ¡ä»¶ã以ãŠãã
ã°ãåå¿ã極ããŠé«ãåçã以ãŠãã¹âãã³ãŸã€
ã³ã®åæã«åã€ãŠå°ãããšãã§ãããåçã¯ãå°
å ¥ããã¢ã«ã«ãªéå±ã·ã¢ã³åç©ã«äžéšå¿ãããã®
ã§ãããååŠéè«éã®ããã15ã20ïŒ ã以ã€ãŠå°
ãªããšã80ïŒ ã®çŽãã¹âãã³ãŸã€ã³ãåŸãããšã
ã§ããããšãèªããããŠããããããŠããã®ãã
ãªåå¿ã«ã€ããŠãã°ãã°èšèŒãããŠããåŠãã30
ã50ã¢ã«ïŒ ã®ã·ã¢ã³åç©ã®äœ¿çšã蚱容ããå Žå
ã¯ããã¹âãã³ãŸã€ã³ã®åçã¯95ïŒ ã«éãããã
ãããè¶ ããããšãããããåŸã€ãŠãäžè¬ã«ãã
ã¬âïŒãŸãã¯ã€ãœâïŒãã¿ã«ã¢ã«ãããïŒã¢ã«ã«
ã€ãã¢ã«ã«ãªéå±ã·ã¢ã³åç©0.3ãïŒã¢ã«ã®å²å
ã§çšããããšã«ãªãã ä»æ¹ãã·ã¢ã³åç©ã®éãçãããã®ãšããã°ã
åå¿ããåºçºåå¿äœã®ãã¹ãŠã溶解ãåŸãããå
å¿çæç©ã«ãšã€ãŠã¯äžéœåãªæº¶åªã§ãããã®ã®äž
ã§è¡ãå Žåããã¹âãã³ãŸã€ã³ã®åçãïŒåã«ãŸ
ã§äžæãåŸãããšãèªãããŠãããäºå®ããã³ãŸ
ã€ã³çž®åã¯äžè¬ã«å¯éåå¿ã§ãããæ±ããçæç©
ãåå¿éäžã«ãããŠæ²æ®¿ã«ãã€ãŠé€å»ããããã
ãšã«ãã€ãŠå¹³è¡¡ãè¯ãæ¹åã«åããããšãå¯èœã§
ããã åå¿ã溶åªãçšããã«è¡ãå Žåã¯ãå®éãè³éŠ
æãžã¢ã«ãããã«å¯Ÿãã圹å²ãå°ãªããšãäžéšæ
ããã®ããéå°ã®ãã³ãºã¢ã«ããããªã®ã§ããã
ããããªãããã¢ã«ã«ãªéå±ã®ã·ã¢ã³åç©ã¯ãã³
ãºã¢ã«ãããã«ã»ãšãã©æº¶è§£ããªããã·ã¢ã³åç©
ã氎溶液ã®åœ¢æ ã§å ããå Žåã¯ãåå¿åªè³ªã¯ïŒã€
ã®æ··åããªãçžã§åœ¢æããããæ°Žçžã®ã·ã¢ã³åç©
ã®ç§»åã¯ãäŸãã°ç¬¬ïŒçŽã¢ã³ã¢ãã¢å¡©ãããã¯ç¬¬
ïŒçŽãã¹ãããŠã å¡©ã®åŠããçžç§»åå€ãæ·»å ãã
ã°ä¿é²ããããšãã§ãããåå¿ã®çµçµã«ãããŠã
ææ©çžã¯é»ã¿ããã€ãããŒã¹ãç¶ã®ç©è³ªãšããŠå
åšãããããããããã¹âãã³ãŸã€ã³ãæœåºãã
ã®ã¯å°é£ã§ããã åå¿æº¶åªããã¢ã«ãããã溶解ãåŸããã·ã¢ã³
åç©ã溶解ããªãå Žåã¯ãã¢ã«ããããå«ãææ©
çžåã³ã·ã¢ã³åç©ãå«ãæ°Žçžã®ïŒçžç³»ã§ããäžèš
ã®å Žåã«ãéšåçã«ã¯ãæ»ãããããã®éãåå¿
ã¯å¶åŸ¡ã極ããŠå°é£ã§ããããã®éãïŒã€ã®çžã
ãä»ã®çžãžã®åå¿äœãžã®ç§»åãéåžžã«å³å¯ãªæ¡ä»¶
äžã«ãããŠè¡ãããªããã°ãªããªãã®ã§ãåå¿ã¯
å¶åŸ¡ã極ããŠåºé£ã§ãããåŸãããçæç©ã¯ç©è³ª
çžã«ãããŠå°éãåŸãçŽåºŠãæããªãã åŸã€ãŠãæ¬çºæã®æ å ã«ãããŠçšãåŸãææ©æº¶
åªã®ãã¡ããããã¬ãã¿ã«ã¢ã«ãããåã³ã·ã¢ã³
åã«ãªãŠã ãŸãã¯ã·ã¢ã³åãããªãŠã ã®åŠãæã
溶解床ã®äœãåºçºååç©ã溶解ãåŸããã®ãéžã¶
ããšã«ãªããèèªæã®äžäŸ¡ã®ç¬¬äžã¢ã«ã³ãŒã«ãç¹
ã«äŸãã°ã¡ã¿ããŒã«åã³ãšã¿ããŒã«ã®åŠãäœçŽã¢
ã«ã³ãŒã«ãæãæå©ãªæº¶åªã§ããããã®äžã§ã¯ã¢
ã«ã«ãªéå±ã·ã¢ã³åç©ãçžåœã«æº¶è§£ããïŒãªãã·
ã¢ã³ã«ãªãŠã ã¯ã·ã¢ã³åãããªãŠã ããå®è³ªçã«
ãã溶解ããïŒãäœçŽã¢ã«ã³ãŒã«ã¯äžè¬ã«ïŒãïŒ
åã®ççŽ ååãå«ãã§ããã ããã«åããŠããã³ãŒã³åã³ãã«ãšã³ã®åŠãè³
éŠæçåæ°ŽçŽ äžã«ãããŠåå¿ãè¡ãããšãèæ ®ã
ãå Žåã¯ãéå±ã®ã·ã¢ã³åç©ã¯æ°Žæº¶æ¶²ãšããŠæ·»å
ããªããã°ãªããªããªãããçž®åã®çµæã¯ãã¹â
ãã³ãŸã€ã³ãå®è³ªçã«äžå±€äœãåçã以ãŠçãã
ããšã«ãªãã§ãããã æ¬çºæã«ããã°ãæå©ã«ã¯ããã¬âïŒãŸãã¯ã€
ãœâïŒãã¿ã«ã¢ã«ãããïŒã¢ã«ã«å¯ŸããŠïŒãïŒ
ã®å²åã®ææ©æº¶åªãçšããã åçš®ã®åå¿äœã®æ·»å æ¹åŒããŸã極ããŠéèŠã§ã
ããæ¬çºæã®æ¹æ³ã¯ãã¢ã«ã«ãªéå±ã®ã·ã¢ã³åç©
ïŒããã¯ã溶解床ã«éã¿ã·ã¢ã³åã«ãªãŠã ã§ãã
ããšãå€ããïŒãè³éŠæãžã¢ã«ãããã®ææ©æº¶æ¶²
ã«å ããããšã«ããæã€ãŠããããã®éãæèµ€è²
ã®ååç©ãæ¥éã«åœ¢æãããããããã«æ¬¡ã«ãã³
ãºã¢ã«ããããå ããããã¯ãã®çè²ããçæç©
ãšãšãã«åå¿ã«å ããããã«ãªãããã¹âãã³ãŸ
ã€ã³ã®åçã¯ãã®æ¡ä»¶äžã«ãããã»ãããã·ã¢ã³
åç©ãïŒçš®ã®ã¢ã«ãããã®å ±é溶液ã«å ããå Žå
ããããæããã«é«ãã è€å®èœåå¿äœãšåå®èœåå¿äœãšã®éã®ãã¹ãŠã®
æ··åçž®ååå¿ã«ãããŠã¯ãè€å®èœååç©ã®éçž®å
ãæ倧éã«å¶çŽããããã«ãéå°ã®åå®èœåå¿äœ
ãçšããã®ãæå©ã§ããããã¹âãã³ãŸã€ã³ãå
æããããã®ååŠéè«æ¯ã¯ããžã¢ã«ãããïŒã¢ã«
ã«å¯ŸããŠãã³ãºã¢ã«ãããïŒã¢ã«ã§ããã100ïŒ
ã®éå°ããªãã¡ïŒã¢ã«ã®ãã³ãºã¢ã«ãããã以ãŠ
ããã°ããžã¢ã«ãããã®ããèªèº«ãžã®éçž®åã¯èµ·
ããªãããåå¿çæç©ã¯ããã³ãºã¢ã«ãããã®ã
ãèªèº«ãšã®çž®åããçããããšã®ãããã³ãŸã€ã³
ã«æ±æãããªããèšããŸã§ããªãããããã倧é
ã®éå°ã®ãã³ãºã¢ã«ããããçšããŠãããããã
ãã¯ãã¹âãã³ãŸã€ã³ã®åçãå®è³ªçã«åäžãã
ããªããäžè¬ã«ã¯ããã¬âïŒãŸãã¯ã€ãœâïŒãã¿
ã«ã¢ã«ãããïŒã¢ã«ã«å¯ŸããŠãã³ãºã¢ã«ããã
3.5ãïŒã¢ã«ãçšããã 枩床ããŸãåå¿ã®åçã«èãã圱é¿ãåãŒãã
åéã®ã¢ã«ã«ãªéå±ã·ã¢ã³åç©ã«å¯ŸããŠãåå¿ã
溶åªã®éæµæž©åºŠã«ãããŠè¡ãå Žåã¯ãäŸãã°30ïŒ
ã®ãã¹âãã³ãŸã€ã³åçãåŸããåå¿ã宀枩ã§è¡
ãæã¯åçã¯65ïŒ ã«ãªããæ¬çºæã«ãããæåã¯
ïŒã30âã®éã«å«ãŸãã宀枩ã«è¿ã枩床ã«ãã
ãŠã次ãã§ããããé«ããäžè¬ã«ã50ã150âã®
éã«å«ãŸãã枩床ã«ãããŠåå¿ãè¡ãå Žåã¯ãã
ã®åçã¯80ïŒ ãããã¯ãã以äžã«éããããšãã
ãããã®ç¬¬ïŒæ®µéã«ãããŠã¯ããããŠãã®å Žåã
溶åªã®éæµæž©åºŠã«ãããŠæäœãè¡ãããããã®
äžããã¹âãã³ãŸã€ã³ã®æ²æ®¿ã®åœ¢æ ã¯å ç±ã«ãã€
ãŠå€åãããåå¿ã宀枩ã«ãããŠè¡ãããå Žåã«
åŸããããæŽæµããããšãéããããšã極床ã«
å°é£ãªéåžžã«çŽ°ããªæ²æ®¿ç©ã®ä»£ãã«ãåå¿åªè³ªã
å ç±ããã°ã容æã«æŽæµåã³éæäœãåããã
ãšã®ã§ãããç²åºŠã®äžå±€å€§ããæ²æ®¿ç©ãçæã
ããæå©ã«ã¯ãïŒå®€æž©ã«è¿ã枩床ã«ãããïŒç¬¬ïŒ
段éã¯0.5ãïŒæéãïŒããããé«ã枩床ã«ãã
ãïŒç¬¬ïŒæ®µéã¯ïŒã10æéæç¶ããã æ¬çºæã®æ¹è¯æ³ã«ãããŠã¯ã極ããŠé«ãçŽåºŠã
æãããã¹âãã³ãŸã€ã³ãé«åçã以ãŠåŸãã
ããåå åæåã³èå±€ã¯ãããã°ã©ãã€ãŒããã
ã¯é«æ§èœã«ã©ã ã»ã¯ãããã°ã©ãã€ãŒã«ããåé¢
æè¡ãæ±æç©ãšãããããªãã®ã¯äœäžã€èšŒæãã
ããšãã§ããªããããã¯ç²ãã¹âãã³ãŸã€ã³ãå°
ãªããšã99ïŒ ã®çŽåºŠãæããŠããããšã§ãããã
ã®ããšã®ããã«ããã®åŸã®ç²Ÿè£œæäœã¯äžåè¡ããª
ããŠãããã ïŒïŒïŒâåã³ïŒïŒïŒâïŒããšãã«ã°ãªãªãã·ã
ã€ã«ïŒãã³ãŒã³åæã®ç¬¬ïŒå·¥çšã¯å¯Ÿå¿ã®ãã¹âã
ã³ãŸã€ã³ã®ãã¹âαãžã±ãã³ãžã®é žåã§ãããã«
ã«ããã«åºã®ïŒäœã®ç¬¬ïŒã¢ã«ã³ãŒã«å®èœåºã®ã±ã
ã³ãžã®å€æã¯æ¢ç¥ã®æè¡ã«ãããäŸãã°é ããã³
ã¬ã³ãã¯ãã ããã¹ãã¹ãéãã»ã¬ããŠã ãã»ãª
ãŠã ãéãªãã³ã«ãã®ä»å€æ°ã®éå±ããèªå°ãã
é žåå€ãçšããŠå®æœããããšãã§ãããç¡é žãã
ãã¯åé žåçªçŽ ããŸãé žåå€ãšããŠçšããããšã
ã§ããã æ¯èŒç倧éã®ãã¹âαâãžã±ãã³ã補é ããã
ãã«ã¯ãé ¢é žé ããã³ç¡é žã¢ã³ã¢ããŠã ã«ããé ž
åæè¡ãæå©ã«çšããããšãã§ããããã®éãåŸ
ãããçæç©ã¯çŽåºŠã極ããŠé«ãããªããã®ç²Ÿè£œ
æäœããå¿ èŠãšããªããååéã®æ¥µããŠå€§ããã
ãªããšãã«ããããµãªã³æš¹èã®è£œé ã«ããã®ãŸãŸ
çšãåŸããã®ã§ããã æ¬çºæã以äžã«èšèŒããå ·äœçãªå®æœäŸã«ãã€
ãŠäžå±€æ確ã«èª¬æãããããã®è©³çŽ°ãªäŸç€ºãšããŠ
è¿°ã¹ããã®ã§ãããéå®çãªãã®ã§ã¯ãªãããã
ãã®å®æœäŸã«ãããŠããã¹âãã³ãŸã€ã³åçã¯çš
ãããžã¢ã«ãããã®éã«å¯ŸããŠèšç®ãããçæç©
ã®çŽåºŠã¯ã¯ãããã°ã©ãã€ãŒã質éåå åæåã³
æ žç£æ°å ±é³Žã«ãã€ãŠæ±ºå®ããã å®æœäŸïŒãïŒïŒïŒåã³14ã¯æ¬çºæãäŸç€ºããã
ã®ã§ããããã®ä»ã®å®æœäŸã¯ãæ¬çºæã«ãããŠã
確å®ããæé©æ¡ä»¶ããããé¢ããæäœæ¡ä»¶äžã«ã
ããŠåŸãçµæã瀺ããã®ã§ããã å®æœäŸ ïŒ (a) æ¹æåšåã³éæµå·åŽåšãåãã20å ¥ãã®å
å¿åšå ã«ãã¡ã¿ããŒã«15åã³ãã¬ãã¿ã«ã¢ã«
ããã625ïœïŒ4.66ã¢ã«ïŒãå ¥ããããžã¢ã«ã
ããã溶解ãããŸã§æ··åç©ãæ¹æããã次ã
ã§ãã·ã¢ã³åã«ãªãŠã 100ïœïŒ1.54ã¢ã«ïŒãããª
ãã¡ååŠéè«éã®çŽ16ïŒ ãå ãããã·ã¢ã³åç©
ã¯æ¥éã«æº¶æ¶²ãšãªããåå¿åªè³ªã¯æèµ€è²ãåã
ãã次ã«ãã³ãºã¢ã«ããã2000ïœïŒ18.9ã¢ã«ïŒ
ãå ãããæ··åç©ã宀枩ã«ãããŠïŒæéæ¹æã
ãã次ãã§ãã¡ã¿ããŒã«ã®éæµæž©åºŠïŒçŽ70âïŒ
ã«ãããŠïŒæéå ç±ããã宀枩ã«å·åŽåŸã圢æ
ããä¹³çœè²ã®æ²æ®¿ç©ãéã«ãã€ãŠåé¢ããæ°Ž
æŽããŠãã·ã¢ã³åç©ãè±é¢ããããæžå§äžã§ä¹Ÿ
ç¥ãããïŒåã®åäžã®æäœã«ã€ããŠããã¹âã
ã³ãŸã€ã³åéã¯1272ïœïŒ79ïŒ ïŒã1340ïœïŒ83
ïŒ ïŒã®éãå€åãããå çŽ åæåã³åå åæ
ïŒèµ€å€ç·ã玫å€ç·ãNMRåã³è³ªéåæïŒã¯åŸ
ãããååç©ãæ±ãããã¹âãã³ãŸã€ã³ã®åŒã«
çžåœãããã®ã§ããããšã瀺ãããèå±€ã¯ãã
ãã°ã©ãã€ãŒåã³é«æ§èœã«ã©ã ã»ã¯ãããã°ã©
ãã€ãŒã«ããåæã¯ãåŸãçæç©ãå°ãªããšã
99ïŒ ã«çããçŽåºŠãæããããšã瀺ããã (b) åŸããããã¹âãã³ãŸã€ã³ã®ïŒïŒïŒâãã¹â
ïŒããšãã«ã°ãªãªãã·ãã€ã«ïŒãã³ãŒã³ãžã®é ž
åã¯äžèšã®æ¹æ³ã«ãã€ãŠå®æœããã èªåæ¹æåšãéæµå·åŽåšåã³äžæŽ»æ§ã¬ã¹åŸªç°
ãåãã20å ¥ãã®åå¿åšå ã«ãé ¢é ž10ãã
ã¹âãã³ãŸã€ã³500ïœãç¡é žã¢ã³ã¢ããŠã 320
ïœãäºæ°Žåé ¢é žé 6.5ïœã次ãã§50容ç©ïŒ ã®æ°Ž
ãæããæ°Žæ§é ¢é žïŒãçžæ¬¡ãã§å ¥ãããæ··å
ç©ãéæµæž©åºŠïŒ110âïŒã«ãããŠ30æéå ç±ãã
次ãã§ïŒãïŒâã®éã«å·åŽãããé»è²ã®çµæ¶æ§
æ²æ®¿ç©ã圢æããããããéã«ãã€ãŠåé¢
ããæ°ŽïŒã以ã€ãŠïŒåæŽæµããã次ãã§100
âã«ãããŠæ°æé也ç¥ããã æ²æ®¿ç©ã®äžåŸååããæ¯æ¶²ãåå¿åšå ãžæ»
ãããã¹âãã³ãŸã€ã³500ïœåã³ç¡é žã¢ã³ã¢ã
ãŠã 320ïœãåã³ä»èŸŒãããã®ïŒåç®ã®ããã
ã®é žåã¯äžè¿°ã®æ¡ä»¶äžã«ãããŠè¡ãã ãã®æäœã¯ãã¹âãã³ãŸã€ã³500ïœåã³ç¡é ž
ã¢ã³ã¢ããŠã 320ïœã®ä»èŸŒã以ãŠããªãïŒåå
埩ããã ãã®ããã«ããŠè£œé ããïŒãããã®ïŒïŒïŒâ
ïŒããšãã«ã°ãªãªãã·ãã€ã«ïŒãã³ãŒã³ã¯ãã
ãã342ïœïŒ450ïœïŒ458ïœãåã³460ïœã®ééã§
ãã€ããããã©ã±ãã³ã®åçã¯ç¬¬ïŒå補é ã«ã€
ããŠã¯70ïŒ ã«è¿ããã€ãã次ãã§ãä»ã®ïŒåã®
補é ã«ã€ããŠã¯91ã93ïŒ ã®éã«å«ãŸããŠããã åŸãããååç©ã®èç¹ã¯127âã§ãããåçš®
ã®åæã¯æåŸ ããæ§é ã«åèŽããŠãããã¯ãã
ãã°ã©ãã€ãŒåæã¯99ïŒ ä»¥äžã®çŽåºŠãæããç©
質ã®ãã ïŒã€ã®ã¿ã®ååšã瀺ããããšã¿ããŒã«
äžã®äžé£ã®åçµæ¶ãçžæ¬¡ãã§ïŒåè¡ã€ãããç²
åå¿çæç©ã®ç©ççç¹æ§åã³åå åæç¹æ§ã«ãª
ããã®å€åãçããªãã€ããåŸã€ãŠããã®ç²ç
æç©ã¯é«ååéã®ããªããšãã«ããããµãªã³ã®
補é ã«ãã®ãŸãŸäœ¿çšã§ããã å®æœäŸ ïŒ ãã¬ãã¿ã«ã¢ã«ãããïŒ625ïœïŒã®ãã³ãºã¢ã«
ãããïŒ2000ïœïŒãšã®ãã³ãŸã€ã³çž®åããååŠé
è«éã®50ïŒ ã«ããã300ïœã®ã·ã¢ã³åã«ãªãŠã ã
çšããŠãå®æœäŸïŒãšæ£ç¢ºã«åäžã®æ¡ä»¶äžã«ãããŠ
åã³è¡ããçŽãã¹âãã³ãŸã€ã³ã®åéã¯1516ïœ
ïŒ94ïŒ ïŒã§ãã€ãããã®çæç©ããé žåã«ãã€ãŠã
極ããŠçŽåºŠã®é«ãïŒïŒïŒâãã¹âïŒããšãã«ã°ãª
ãªãã·ãã€ã«ïŒãã³ãŒã³ã®90ïŒ ãçãããåŸã€
ãŠãããã©ã±ãã³ã®åçã¯çšãããã¬ãã¿ã«ã¢ã«
ãããã«å¯ŸããŠ85ïŒ ã«è¿ããã€ãã å®æœäŸ ïŒ ã€ãœãã¿ã«ã¢ã«ããããšãã³ãºã¢ã«ãããã®é
ã®ãã³ãŸã€ã³çž®åãå®æœäŸïŒã®æ¡ä»¶äžã«ãããŠè¡
ãããã®ãžã¢ã«ãããã®é«ã溶解床ã®ããã«ã15
ã®ã¡ã¿ããŒã«äžã§åå¿ããããéãå¢å ããã
ãšãã§ãããããªãã¡ãã€ãœãã¿ã«ã¢ã«ãããã«
ã€ããŠã¯1430ïœïŒ10ã¢ã«ïŒãã·ã¢ã³åã«ãªãŠã ã«
ã€ããŠã¯260ïœïŒïŒã¢ã«ïŒïŒããªãã¡ååŠéè«éã®
20ïŒ ïŒåã³ãã³ãºã¢ã«ãããã«ã€ããŠã¯240ïœ
ïŒ40ã¢ã«ïŒã§ããããã®æäœã«ããæ±ãããã¹â
ãã³ãŸã€ã³2770ïœïŒ80ïŒ ïŒãåŸãã åŸãããååç©ããçŽ920ïœã®ïŒãããã«åã
ãŠãå®æœäŸïŒã®æ¡ä»¶äžã«ãããŠé žåãããïŒïŒïŒ
âãã¹âïŒããšãã«ã°ãªãªãã·ãã€ã«ïŒãã³ãŒã³
ã®åçã¯ïŒïŒïŒâãã¹âãã³ãŸã€ã³ã«å¯ŸããŠ85
ïŒ ãåºçºåæã€ãœãã¿ã«ã¢ã«ãããã«å¯ŸããŠçŽ68
ïŒ ã§ãã€ãã åŸãããååç©ã®èç¹ã¯101âã§ãããåçš®ã®
åæã¯æåŸ ããæ§é ã«åèŽããŠãããã¯ãããã°
ã©ãã€ãŒåæã¯99.1ïŒ ã®çŽåºŠãæããç©è³ªã®ãã
ïŒã€ã®ã¿ã®ååšã瀺ããããšãããŒã«äžã®äžé£ã®
åçµæ¶ãçžæ¬¡ãã§ïŒåè¡ãªã€ãããç²åå¿çæç©
ã®ç©ççç¹æ§åã³åå åæç¹æ§ã«ãªããã®å€åã
çããªãã€ããåŸã€ãŠããã®ç²çæç©ãé«ååé
ã®ããªããšãã«ããããµãªã³ã®è£œé ã«ãã®ãŸãŸäœ¿
çšã§ããã å®æœäŸ ïŒ ãããã®å®æœäŸã¯åçš®ã®èŠå ïŒã·ã¢ã³åç©ã®
éã溶åªã®å®¹ç©ãåå¿æž©åºŠåã³åå¿æéïŒã®ãã¹
âãã³ãŸã€ã³åéåã³ãã®ååç©ã®çŽåºŠã«åãŒã
圱é¿ã瀺ãããã®ãã®ã§ããã å®éšã¯ãã¬ãã¿ã«ã¢ã«ããã80ïœïŒ0.597ã¢ã«ïŒ
åã³ãã³ãºã¢ã«ããã250ïœïŒ2.36ã¢ã«ïŒãã¡ã¿
ããŒã«äžã«æº¶è§£ããŠå®æœããã次ãã§è¡šïŒã«ç€ºã
éã®ã·ã¢ã³åã«ãªãŠã ãå ããåè¡šã«ç€ºã枩床å
ã³æéã®è«žæ¡ä»¶ã«åŸã€ãŠåå¿ãè¡ã€ãã
補é ã«ãããã¢ãããŒã§ããïŒïŒïŒâãã¹â
ïŒïŒããšãã«ã°ãªãªãã·ãã€ã«ïŒãã³ãŒã³åã³ïŒïŒ
ïŒâãã¹âïŒããšãã«ã°ãªãªãã·ãã€ã«ïŒãã³ãŒ
ã³ã®æ¹è¯åææ³ã«é¢ããã çŸåšã®æè¡æ°Žæºã«ãããŠã¯ãããªããšãã«ãã
ããµãªã³æš¹èã¯èç±æ§ãé žååã³ååŠè¬åã«å¯Ÿã
ãæµæåãšãã€ãç¹æã®ç¹æ§ãæããŠããããã
ã®äœ¿çšã®æ®åã«ã¯åºçºåæããã¢ãããŒå°±äžè³éŠ
æãã¹âαâãžã±ãã³ã®é«ãäŸ¡æ Œãé害ã«ãªã€ãŠ
ããããšãç¥ãããŠããããããã®ååç©ã®åæ
åå¿ã¯ãäºå®ãçšæã§é«äŸ¡ãªåå¿äœã®åãåãå€
æ°ã®äžéå·¥çšãå¿ èŠãšããã è³éŠæαâãžã±ãã³ãžã®æè¯ã®æ¥è¿æ³ã¯ããã³
ãŸã€ã³ãšåŒã°ãã察å¿ã®Î±âã±ãã¢ã«ã³ãŒã«ã®é ž
åã§ããããšããŸãç¥ãããŠãããäžè¬ã«ãã³ãŸ
ã€ã³ã¯ãïŒçš®ä¹è³æ°çš®ã®è³éŠæã¢ã«ãããããå
åŠéè«éããé¥ãã«å°ãªãéã§çšãããã¢ã«ã«ãª
éå±ã®ã·ã¢ã³åç©ã®ååšäžã«ãããŠçž®åããããŠ
補é ãããããšããã§ããã¬ãã¿ã«ã¢ã«ããããš
ãã³ãºã¢ã«ãããã®æ··åãã³ãŸã€ã³çž®åã«ãã€ãŠ
ã¯ãæåŸ ãããã¹âãã³ãŸã€ã³ãçããªãããšã
æè¿ç€ºãããïŒKratzer et coll.ïŒJ.Org.Chem.ïŒ
41ïŒ1976ïŒïŒ2230ïŒããã®ååç©ãåŸãã«ã¯ãå ã
ãã¬ãã¿ã«ã¢ã«ãããã®ãã¹éäºç¡«é žä»å ç©ã補
é ãã次ãã§ãããïŒã¢ã«ã®ã·ã¢ã³åã«ãªãŠã ãš
åå¿ããããŠãã¹âãã¬ãã¿ã«ã·ã¢ã³ãããªã³ã
åæããããã«ããã倧éå°ã®ãã³ãºã¢ã«ããã
ãšçž®åããããããšãå¿ èŠã§ãã€ãããã®æ¹æ³
ã¯ããã³ãŸã€ã³çž®åã«æ¯ããŠã倧éã®ã·ã¢ã³åã«
ãªãŠã ã䜿çšããããå€ãã®å¥ã ã®åå¿å·¥çšãèŠ
ãããšããäžéœåã瀺ãããšãããã€ãŠããã ããçš®ã®æ確ãªæ¡ä»¶äžã«ãããŠã¯ãäžæ¹ã«ãã
ãŠãã³ãºã¢ã«ããããšãä»æ¹ã«ãããŠãã¬ãã¿ã«
ã¢ã«ãããåã³ã€ãœãã¿ã«ã¢ã«ãããã®éã®æ··å
ãã³ãŸã€ã³çž®ååå¿ã®å®æœãå¯èœã§ããããšãèŠ
åºãããâããããŠãããæ¬çºæã®ç®çã§ããã
ãã®æ¡ä»¶äžã«ãããŠã¯ãåŸããããã¹âãã³ãŸã€
ã³ã¯99ïŒ ä»¥äžã®çŽåºŠãæããããã察å¿ãããã¹
âαâãžã±ãã³ã«é žåããåã«ç²Ÿè£œããå¿ èŠããª
ãããšããŸãèŠåºããããããæ ã«ããã®åŸè ã®
ååç©ã¯ãã®ãŸãŸæè¬ãããªããŒåãçŽåºŠãããª
ãã¡99ïŒ ä»¥äžã®çŽåºŠãæããŠããã æ¬çºæã®æ¹æ³ã«ããã°ãå ã第äžã«ãäžèšã®åŒ ãããã¯äžèšã®åŒ ã«çžåœãããã¹âãã³ãŸã€ã³ã補é ããã ãã®ããã«ã¯ãäžè¬çã«ã¯ãäžèšã®åŠã確å®ã
ãé£ç¶æäœãè¡ããããªãã¡ (a) ãã¬ãã¿ã«ã¢ã«ããããŸãã¯ã€ãœãã¿ã«ã¢ã«
ããããããã¬âïŒãŸãã¯ã€ãœâïŒãã¿ã«ã¢ã«
ãããã溶解ãåŸãããæ±ãããã¹âãã³ãŸã€
ã³ã溶解ããªã溶åªäžã«ãããŠããã¬âïŒãŸã
ã¯ã€ãœâïŒãã¿ã«ã¢ã«ãããïŒã¢ã«ã«å¯ŸããŠïŒ
ã¢ã«ãšããååŠéè«éããäœãå²åã®ã¢ã«ã«ãª
éå±ã·ã¢ã³åç©ãšåå¿ããããã (b) ãã¬âïŒãŸãã¯ã€ãœâïŒãã¿ã«ã¢ã«ãããïŒ
ã¢ã«ã«å¯ŸãïŒã¢ã«ãšããååŠéè«éã«å¯ŸããŠé
å°ã®ãã³ãºã¢ã«ãããïŒäžè¬ã«3.5ãïŒã¢ã«ïŒ
ã圢æããåå¿åªè³ªãåå¿ããããããã®å·¥çš
(b)ã¯å®€æž©ãäŸãã°çŽïŒã30âã«è¿ã枩床ã«ãã
ãŠå®æœããã次ãã§ã (c) åå¿åªè³ªãçŽ50ã150âã®æž©åºŠãäžè¬ã«ã¯æº¶
åªã®éæµæž©åºŠã«å ç±ããã ãã®æ¹æ³ã«ãã€ãŠããã¹âãã³ãŸã€ã³ã¯é«åç
åã³é«çŽåºŠã以ãŠåŸãããšãã§ããã çšããæäœæ¡ä»¶ã®éžå®ã®éèŠæ§ãäŸç€ºãããã
ã«ãæ··åãã³ãŸã€ã³çž®åã®æ©æ§ãäžèšã®åŠãåå¿
ã·ãŒã±ã³ã¹ã以ãŠèª¬æããããšã«ããã ã¢ã«ã«ãªéå±ã®ã·ã¢ã³åç©ã¯è³éŠæãžã¢ã«ãã
ãïŒã¢ã«ã«ã€ãïŒã¢ã«ãšããå²åããé¥ãã«å°é
ã§åªè³ªäžã«ã€ãååšããŠããã®ã§ããã¹âãã³ãŸ
ã€ã³ã®åçã¯ãåãã³ãŸã€ã³ãçãããããã³ãº
ã¢ã«ãããèªèº«ãžã®çž®åãããªãã¡ã ããã㯠åã®ããªãã³ãŸã€ã³ãçãããžã¢ã«ãããèªèº«ãž
ã®çž®åãæ倧éã«åé¿ããã°ãããã ãé«ããªã
ããšã«ãªãã ãããã®åå¿åã³ãã®ä»ã®å¯æ¬¡çãªåå¿ã¯ãé
åžžã®æ¡ä»¶äžã«ãããŠã¯ããã³ãºã¢ã«ãããã®ãã¬
ãã¿ã«ã¢ã«ããããŸãã€ãœãã¿ã«ã¢ã«ããããšã®
æ··åãã³ãŸã€ã³çž®åããäž»ãšããŠã¿ãŒã«ãšæ¥µããŠ
å°éã®ãã¹âãã³ãŸã€ã³ãçããããã ããã«åããŠãæ¬çºæã®æäœæ¡ä»¶ã以ãŠãã
ã°ãåå¿ã極ããŠé«ãåçã以ãŠãã¹âãã³ãŸã€
ã³ã®åæã«åã€ãŠå°ãããšãã§ãããåçã¯ãå°
å ¥ããã¢ã«ã«ãªéå±ã·ã¢ã³åç©ã«äžéšå¿ãããã®
ã§ãããååŠéè«éã®ããã15ã20ïŒ ã以ã€ãŠå°
ãªããšã80ïŒ ã®çŽãã¹âãã³ãŸã€ã³ãåŸãããšã
ã§ããããšãèªããããŠããããããŠããã®ãã
ãªåå¿ã«ã€ããŠãã°ãã°èšèŒãããŠããåŠãã30
ã50ã¢ã«ïŒ ã®ã·ã¢ã³åç©ã®äœ¿çšã蚱容ããå Žå
ã¯ããã¹âãã³ãŸã€ã³ã®åçã¯95ïŒ ã«éãããã
ãããè¶ ããããšãããããåŸã€ãŠãäžè¬ã«ãã
ã¬âïŒãŸãã¯ã€ãœâïŒãã¿ã«ã¢ã«ãããïŒã¢ã«ã«
ã€ãã¢ã«ã«ãªéå±ã·ã¢ã³åç©0.3ãïŒã¢ã«ã®å²å
ã§çšããããšã«ãªãã ä»æ¹ãã·ã¢ã³åç©ã®éãçãããã®ãšããã°ã
åå¿ããåºçºåå¿äœã®ãã¹ãŠã溶解ãåŸãããå
å¿çæç©ã«ãšã€ãŠã¯äžéœåãªæº¶åªã§ãããã®ã®äž
ã§è¡ãå Žåããã¹âãã³ãŸã€ã³ã®åçãïŒåã«ãŸ
ã§äžæãåŸãããšãèªãããŠãããäºå®ããã³ãŸ
ã€ã³çž®åã¯äžè¬ã«å¯éåå¿ã§ãããæ±ããçæç©
ãåå¿éäžã«ãããŠæ²æ®¿ã«ãã€ãŠé€å»ããããã
ãšã«ãã€ãŠå¹³è¡¡ãè¯ãæ¹åã«åããããšãå¯èœã§
ããã åå¿ã溶åªãçšããã«è¡ãå Žåã¯ãå®éãè³éŠ
æãžã¢ã«ãããã«å¯Ÿãã圹å²ãå°ãªããšãäžéšæ
ããã®ããéå°ã®ãã³ãºã¢ã«ããããªã®ã§ããã
ããããªãããã¢ã«ã«ãªéå±ã®ã·ã¢ã³åç©ã¯ãã³
ãºã¢ã«ãããã«ã»ãšãã©æº¶è§£ããªããã·ã¢ã³åç©
ã氎溶液ã®åœ¢æ ã§å ããå Žåã¯ãåå¿åªè³ªã¯ïŒã€
ã®æ··åããªãçžã§åœ¢æããããæ°Žçžã®ã·ã¢ã³åç©
ã®ç§»åã¯ãäŸãã°ç¬¬ïŒçŽã¢ã³ã¢ãã¢å¡©ãããã¯ç¬¬
ïŒçŽãã¹ãããŠã å¡©ã®åŠããçžç§»åå€ãæ·»å ãã
ã°ä¿é²ããããšãã§ãããåå¿ã®çµçµã«ãããŠã
ææ©çžã¯é»ã¿ããã€ãããŒã¹ãç¶ã®ç©è³ªãšããŠå
åšãããããããããã¹âãã³ãŸã€ã³ãæœåºãã
ã®ã¯å°é£ã§ããã åå¿æº¶åªããã¢ã«ãããã溶解ãåŸããã·ã¢ã³
åç©ã溶解ããªãå Žåã¯ãã¢ã«ããããå«ãææ©
çžåã³ã·ã¢ã³åç©ãå«ãæ°Žçžã®ïŒçžç³»ã§ããäžèš
ã®å Žåã«ãéšåçã«ã¯ãæ»ãããããã®éãåå¿
ã¯å¶åŸ¡ã極ããŠå°é£ã§ããããã®éãïŒã€ã®çžã
ãä»ã®çžãžã®åå¿äœãžã®ç§»åãéåžžã«å³å¯ãªæ¡ä»¶
äžã«ãããŠè¡ãããªããã°ãªããªãã®ã§ãåå¿ã¯
å¶åŸ¡ã極ããŠåºé£ã§ãããåŸãããçæç©ã¯ç©è³ª
çžã«ãããŠå°éãåŸãçŽåºŠãæããªãã åŸã€ãŠãæ¬çºæã®æ å ã«ãããŠçšãåŸãææ©æº¶
åªã®ãã¡ããããã¬ãã¿ã«ã¢ã«ãããåã³ã·ã¢ã³
åã«ãªãŠã ãŸãã¯ã·ã¢ã³åãããªãŠã ã®åŠãæã
溶解床ã®äœãåºçºååç©ã溶解ãåŸããã®ãéžã¶
ããšã«ãªããèèªæã®äžäŸ¡ã®ç¬¬äžã¢ã«ã³ãŒã«ãç¹
ã«äŸãã°ã¡ã¿ããŒã«åã³ãšã¿ããŒã«ã®åŠãäœçŽã¢
ã«ã³ãŒã«ãæãæå©ãªæº¶åªã§ããããã®äžã§ã¯ã¢
ã«ã«ãªéå±ã·ã¢ã³åç©ãçžåœã«æº¶è§£ããïŒãªãã·
ã¢ã³ã«ãªãŠã ã¯ã·ã¢ã³åãããªãŠã ããå®è³ªçã«
ãã溶解ããïŒãäœçŽã¢ã«ã³ãŒã«ã¯äžè¬ã«ïŒãïŒ
åã®ççŽ ååãå«ãã§ããã ããã«åããŠããã³ãŒã³åã³ãã«ãšã³ã®åŠãè³
éŠæçåæ°ŽçŽ äžã«ãããŠåå¿ãè¡ãããšãèæ ®ã
ãå Žåã¯ãéå±ã®ã·ã¢ã³åç©ã¯æ°Žæº¶æ¶²ãšããŠæ·»å
ããªããã°ãªããªããªãããçž®åã®çµæã¯ãã¹â
ãã³ãŸã€ã³ãå®è³ªçã«äžå±€äœãåçã以ãŠçãã
ããšã«ãªãã§ãããã æ¬çºæã«ããã°ãæå©ã«ã¯ããã¬âïŒãŸãã¯ã€
ãœâïŒãã¿ã«ã¢ã«ãããïŒã¢ã«ã«å¯ŸããŠïŒãïŒ
ã®å²åã®ææ©æº¶åªãçšããã åçš®ã®åå¿äœã®æ·»å æ¹åŒããŸã極ããŠéèŠã§ã
ããæ¬çºæã®æ¹æ³ã¯ãã¢ã«ã«ãªéå±ã®ã·ã¢ã³åç©
ïŒããã¯ã溶解床ã«éã¿ã·ã¢ã³åã«ãªãŠã ã§ãã
ããšãå€ããïŒãè³éŠæãžã¢ã«ãããã®ææ©æº¶æ¶²
ã«å ããããšã«ããæã€ãŠããããã®éãæèµ€è²
ã®ååç©ãæ¥éã«åœ¢æãããããããã«æ¬¡ã«ãã³
ãºã¢ã«ããããå ããããã¯ãã®çè²ããçæç©
ãšãšãã«åå¿ã«å ããããã«ãªãããã¹âãã³ãŸ
ã€ã³ã®åçã¯ãã®æ¡ä»¶äžã«ãããã»ãããã·ã¢ã³
åç©ãïŒçš®ã®ã¢ã«ãããã®å ±é溶液ã«å ããå Žå
ããããæããã«é«ãã è€å®èœåå¿äœãšåå®èœåå¿äœãšã®éã®ãã¹ãŠã®
æ··åçž®ååå¿ã«ãããŠã¯ãè€å®èœååç©ã®éçž®å
ãæ倧éã«å¶çŽããããã«ãéå°ã®åå®èœåå¿äœ
ãçšããã®ãæå©ã§ããããã¹âãã³ãŸã€ã³ãå
æããããã®ååŠéè«æ¯ã¯ããžã¢ã«ãããïŒã¢ã«
ã«å¯ŸããŠãã³ãºã¢ã«ãããïŒã¢ã«ã§ããã100ïŒ
ã®éå°ããªãã¡ïŒã¢ã«ã®ãã³ãºã¢ã«ãããã以ãŠ
ããã°ããžã¢ã«ãããã®ããèªèº«ãžã®éçž®åã¯èµ·
ããªãããåå¿çæç©ã¯ããã³ãºã¢ã«ãããã®ã
ãèªèº«ãšã®çž®åããçããããšã®ãããã³ãŸã€ã³
ã«æ±æãããªããèšããŸã§ããªãããããã倧é
ã®éå°ã®ãã³ãºã¢ã«ããããçšããŠãããããã
ãã¯ãã¹âãã³ãŸã€ã³ã®åçãå®è³ªçã«åäžãã
ããªããäžè¬ã«ã¯ããã¬âïŒãŸãã¯ã€ãœâïŒãã¿
ã«ã¢ã«ãããïŒã¢ã«ã«å¯ŸããŠãã³ãºã¢ã«ããã
3.5ãïŒã¢ã«ãçšããã 枩床ããŸãåå¿ã®åçã«èãã圱é¿ãåãŒãã
åéã®ã¢ã«ã«ãªéå±ã·ã¢ã³åç©ã«å¯ŸããŠãåå¿ã
溶åªã®éæµæž©åºŠã«ãããŠè¡ãå Žåã¯ãäŸãã°30ïŒ
ã®ãã¹âãã³ãŸã€ã³åçãåŸããåå¿ã宀枩ã§è¡
ãæã¯åçã¯65ïŒ ã«ãªããæ¬çºæã«ãããæåã¯
ïŒã30âã®éã«å«ãŸãã宀枩ã«è¿ã枩床ã«ãã
ãŠã次ãã§ããããé«ããäžè¬ã«ã50ã150âã®
éã«å«ãŸãã枩床ã«ãããŠåå¿ãè¡ãå Žåã¯ãã
ã®åçã¯80ïŒ ãããã¯ãã以äžã«éããããšãã
ãããã®ç¬¬ïŒæ®µéã«ãããŠã¯ããããŠãã®å Žåã
溶åªã®éæµæž©åºŠã«ãããŠæäœãè¡ãããããã®
äžããã¹âãã³ãŸã€ã³ã®æ²æ®¿ã®åœ¢æ ã¯å ç±ã«ãã€
ãŠå€åãããåå¿ã宀枩ã«ãããŠè¡ãããå Žåã«
åŸããããæŽæµããããšãéããããšã極床ã«
å°é£ãªéåžžã«çŽ°ããªæ²æ®¿ç©ã®ä»£ãã«ãåå¿åªè³ªã
å ç±ããã°ã容æã«æŽæµåã³éæäœãåããã
ãšã®ã§ãããç²åºŠã®äžå±€å€§ããæ²æ®¿ç©ãçæã
ããæå©ã«ã¯ãïŒå®€æž©ã«è¿ã枩床ã«ãããïŒç¬¬ïŒ
段éã¯0.5ãïŒæéãïŒããããé«ã枩床ã«ãã
ãïŒç¬¬ïŒæ®µéã¯ïŒã10æéæç¶ããã æ¬çºæã®æ¹è¯æ³ã«ãããŠã¯ã極ããŠé«ãçŽåºŠã
æãããã¹âãã³ãŸã€ã³ãé«åçã以ãŠåŸãã
ããåå åæåã³èå±€ã¯ãããã°ã©ãã€ãŒããã
ã¯é«æ§èœã«ã©ã ã»ã¯ãããã°ã©ãã€ãŒã«ããåé¢
æè¡ãæ±æç©ãšãããããªãã®ã¯äœäžã€èšŒæãã
ããšãã§ããªããããã¯ç²ãã¹âãã³ãŸã€ã³ãå°
ãªããšã99ïŒ ã®çŽåºŠãæããŠããããšã§ãããã
ã®ããšã®ããã«ããã®åŸã®ç²Ÿè£œæäœã¯äžåè¡ããª
ããŠãããã ïŒïŒïŒâåã³ïŒïŒïŒâïŒããšãã«ã°ãªãªãã·ã
ã€ã«ïŒãã³ãŒã³åæã®ç¬¬ïŒå·¥çšã¯å¯Ÿå¿ã®ãã¹âã
ã³ãŸã€ã³ã®ãã¹âαãžã±ãã³ãžã®é žåã§ãããã«
ã«ããã«åºã®ïŒäœã®ç¬¬ïŒã¢ã«ã³ãŒã«å®èœåºã®ã±ã
ã³ãžã®å€æã¯æ¢ç¥ã®æè¡ã«ãããäŸãã°é ããã³
ã¬ã³ãã¯ãã ããã¹ãã¹ãéãã»ã¬ããŠã ãã»ãª
ãŠã ãéãªãã³ã«ãã®ä»å€æ°ã®éå±ããèªå°ãã
é žåå€ãçšããŠå®æœããããšãã§ãããç¡é žãã
ãã¯åé žåçªçŽ ããŸãé žåå€ãšããŠçšããããšã
ã§ããã æ¯èŒç倧éã®ãã¹âαâãžã±ãã³ã補é ããã
ãã«ã¯ãé ¢é žé ããã³ç¡é žã¢ã³ã¢ããŠã ã«ããé ž
åæè¡ãæå©ã«çšããããšãã§ããããã®éãåŸ
ãããçæç©ã¯çŽåºŠã極ããŠé«ãããªããã®ç²Ÿè£œ
æäœããå¿ èŠãšããªããååéã®æ¥µããŠå€§ããã
ãªããšãã«ããããµãªã³æš¹èã®è£œé ã«ããã®ãŸãŸ
çšãåŸããã®ã§ããã æ¬çºæã以äžã«èšèŒããå ·äœçãªå®æœäŸã«ãã€
ãŠäžå±€æ確ã«èª¬æãããããã®è©³çŽ°ãªäŸç€ºãšããŠ
è¿°ã¹ããã®ã§ãããéå®çãªãã®ã§ã¯ãªãããã
ãã®å®æœäŸã«ãããŠããã¹âãã³ãŸã€ã³åçã¯çš
ãããžã¢ã«ãããã®éã«å¯ŸããŠèšç®ãããçæç©
ã®çŽåºŠã¯ã¯ãããã°ã©ãã€ãŒã質éåå åæåã³
æ žç£æ°å ±é³Žã«ãã€ãŠæ±ºå®ããã å®æœäŸïŒãïŒïŒïŒåã³14ã¯æ¬çºæãäŸç€ºããã
ã®ã§ããããã®ä»ã®å®æœäŸã¯ãæ¬çºæã«ãããŠã
確å®ããæé©æ¡ä»¶ããããé¢ããæäœæ¡ä»¶äžã«ã
ããŠåŸãçµæã瀺ããã®ã§ããã å®æœäŸ ïŒ (a) æ¹æåšåã³éæµå·åŽåšãåãã20å ¥ãã®å
å¿åšå ã«ãã¡ã¿ããŒã«15åã³ãã¬ãã¿ã«ã¢ã«
ããã625ïœïŒ4.66ã¢ã«ïŒãå ¥ããããžã¢ã«ã
ããã溶解ãããŸã§æ··åç©ãæ¹æããã次ã
ã§ãã·ã¢ã³åã«ãªãŠã 100ïœïŒ1.54ã¢ã«ïŒãããª
ãã¡ååŠéè«éã®çŽ16ïŒ ãå ãããã·ã¢ã³åç©
ã¯æ¥éã«æº¶æ¶²ãšãªããåå¿åªè³ªã¯æèµ€è²ãåã
ãã次ã«ãã³ãºã¢ã«ããã2000ïœïŒ18.9ã¢ã«ïŒ
ãå ãããæ··åç©ã宀枩ã«ãããŠïŒæéæ¹æã
ãã次ãã§ãã¡ã¿ããŒã«ã®éæµæž©åºŠïŒçŽ70âïŒ
ã«ãããŠïŒæéå ç±ããã宀枩ã«å·åŽåŸã圢æ
ããä¹³çœè²ã®æ²æ®¿ç©ãéã«ãã€ãŠåé¢ããæ°Ž
æŽããŠãã·ã¢ã³åç©ãè±é¢ããããæžå§äžã§ä¹Ÿ
ç¥ãããïŒåã®åäžã®æäœã«ã€ããŠããã¹âã
ã³ãŸã€ã³åéã¯1272ïœïŒ79ïŒ ïŒã1340ïœïŒ83
ïŒ ïŒã®éãå€åãããå çŽ åæåã³åå åæ
ïŒèµ€å€ç·ã玫å€ç·ãNMRåã³è³ªéåæïŒã¯åŸ
ãããååç©ãæ±ãããã¹âãã³ãŸã€ã³ã®åŒã«
çžåœãããã®ã§ããããšã瀺ãããèå±€ã¯ãã
ãã°ã©ãã€ãŒåã³é«æ§èœã«ã©ã ã»ã¯ãããã°ã©
ãã€ãŒã«ããåæã¯ãåŸãçæç©ãå°ãªããšã
99ïŒ ã«çããçŽåºŠãæããããšã瀺ããã (b) åŸããããã¹âãã³ãŸã€ã³ã®ïŒïŒïŒâãã¹â
ïŒããšãã«ã°ãªãªãã·ãã€ã«ïŒãã³ãŒã³ãžã®é ž
åã¯äžèšã®æ¹æ³ã«ãã€ãŠå®æœããã èªåæ¹æåšãéæµå·åŽåšåã³äžæŽ»æ§ã¬ã¹åŸªç°
ãåãã20å ¥ãã®åå¿åšå ã«ãé ¢é ž10ãã
ã¹âãã³ãŸã€ã³500ïœãç¡é žã¢ã³ã¢ããŠã 320
ïœãäºæ°Žåé ¢é žé 6.5ïœã次ãã§50容ç©ïŒ ã®æ°Ž
ãæããæ°Žæ§é ¢é žïŒãçžæ¬¡ãã§å ¥ãããæ··å
ç©ãéæµæž©åºŠïŒ110âïŒã«ãããŠ30æéå ç±ãã
次ãã§ïŒãïŒâã®éã«å·åŽãããé»è²ã®çµæ¶æ§
æ²æ®¿ç©ã圢æããããããéã«ãã€ãŠåé¢
ããæ°ŽïŒã以ã€ãŠïŒåæŽæµããã次ãã§100
âã«ãããŠæ°æé也ç¥ããã æ²æ®¿ç©ã®äžåŸååããæ¯æ¶²ãåå¿åšå ãžæ»
ãããã¹âãã³ãŸã€ã³500ïœåã³ç¡é žã¢ã³ã¢ã
ãŠã 320ïœãåã³ä»èŸŒãããã®ïŒåç®ã®ããã
ã®é žåã¯äžè¿°ã®æ¡ä»¶äžã«ãããŠè¡ãã ãã®æäœã¯ãã¹âãã³ãŸã€ã³500ïœåã³ç¡é ž
ã¢ã³ã¢ããŠã 320ïœã®ä»èŸŒã以ãŠããªãïŒåå
埩ããã ãã®ããã«ããŠè£œé ããïŒãããã®ïŒïŒïŒâ
ïŒããšãã«ã°ãªãªãã·ãã€ã«ïŒãã³ãŒã³ã¯ãã
ãã342ïœïŒ450ïœïŒ458ïœãåã³460ïœã®ééã§
ãã€ããããã©ã±ãã³ã®åçã¯ç¬¬ïŒå補é ã«ã€
ããŠã¯70ïŒ ã«è¿ããã€ãã次ãã§ãä»ã®ïŒåã®
補é ã«ã€ããŠã¯91ã93ïŒ ã®éã«å«ãŸããŠããã åŸãããååç©ã®èç¹ã¯127âã§ãããåçš®
ã®åæã¯æåŸ ããæ§é ã«åèŽããŠãããã¯ãã
ãã°ã©ãã€ãŒåæã¯99ïŒ ä»¥äžã®çŽåºŠãæããç©
質ã®ãã ïŒã€ã®ã¿ã®ååšã瀺ããããšã¿ããŒã«
äžã®äžé£ã®åçµæ¶ãçžæ¬¡ãã§ïŒåè¡ã€ãããç²
åå¿çæç©ã®ç©ççç¹æ§åã³åå åæç¹æ§ã«ãª
ããã®å€åãçããªãã€ããåŸã€ãŠããã®ç²ç
æç©ã¯é«ååéã®ããªããšãã«ããããµãªã³ã®
補é ã«ãã®ãŸãŸäœ¿çšã§ããã å®æœäŸ ïŒ ãã¬ãã¿ã«ã¢ã«ãããïŒ625ïœïŒã®ãã³ãºã¢ã«
ãããïŒ2000ïœïŒãšã®ãã³ãŸã€ã³çž®åããååŠé
è«éã®50ïŒ ã«ããã300ïœã®ã·ã¢ã³åã«ãªãŠã ã
çšããŠãå®æœäŸïŒãšæ£ç¢ºã«åäžã®æ¡ä»¶äžã«ãããŠ
åã³è¡ããçŽãã¹âãã³ãŸã€ã³ã®åéã¯1516ïœ
ïŒ94ïŒ ïŒã§ãã€ãããã®çæç©ããé žåã«ãã€ãŠã
極ããŠçŽåºŠã®é«ãïŒïŒïŒâãã¹âïŒããšãã«ã°ãª
ãªãã·ãã€ã«ïŒãã³ãŒã³ã®90ïŒ ãçãããåŸã€
ãŠãããã©ã±ãã³ã®åçã¯çšãããã¬ãã¿ã«ã¢ã«
ãããã«å¯ŸããŠ85ïŒ ã«è¿ããã€ãã å®æœäŸ ïŒ ã€ãœãã¿ã«ã¢ã«ããããšãã³ãºã¢ã«ãããã®é
ã®ãã³ãŸã€ã³çž®åãå®æœäŸïŒã®æ¡ä»¶äžã«ãããŠè¡
ãããã®ãžã¢ã«ãããã®é«ã溶解床ã®ããã«ã15
ã®ã¡ã¿ããŒã«äžã§åå¿ããããéãå¢å ããã
ãšãã§ãããããªãã¡ãã€ãœãã¿ã«ã¢ã«ãããã«
ã€ããŠã¯1430ïœïŒ10ã¢ã«ïŒãã·ã¢ã³åã«ãªãŠã ã«
ã€ããŠã¯260ïœïŒïŒã¢ã«ïŒïŒããªãã¡ååŠéè«éã®
20ïŒ ïŒåã³ãã³ãºã¢ã«ãããã«ã€ããŠã¯240ïœ
ïŒ40ã¢ã«ïŒã§ããããã®æäœã«ããæ±ãããã¹â
ãã³ãŸã€ã³2770ïœïŒ80ïŒ ïŒãåŸãã åŸãããååç©ããçŽ920ïœã®ïŒãããã«åã
ãŠãå®æœäŸïŒã®æ¡ä»¶äžã«ãããŠé žåãããïŒïŒïŒ
âãã¹âïŒããšãã«ã°ãªãªãã·ãã€ã«ïŒãã³ãŒã³
ã®åçã¯ïŒïŒïŒâãã¹âãã³ãŸã€ã³ã«å¯ŸããŠ85
ïŒ ãåºçºåæã€ãœãã¿ã«ã¢ã«ãããã«å¯ŸããŠçŽ68
ïŒ ã§ãã€ãã åŸãããååç©ã®èç¹ã¯101âã§ãããåçš®ã®
åæã¯æåŸ ããæ§é ã«åèŽããŠãããã¯ãããã°
ã©ãã€ãŒåæã¯99.1ïŒ ã®çŽåºŠãæããç©è³ªã®ãã
ïŒã€ã®ã¿ã®ååšã瀺ããããšãããŒã«äžã®äžé£ã®
åçµæ¶ãçžæ¬¡ãã§ïŒåè¡ãªã€ãããç²åå¿çæç©
ã®ç©ççç¹æ§åã³åå åæç¹æ§ã«ãªããã®å€åã
çããªãã€ããåŸã€ãŠããã®ç²çæç©ãé«ååé
ã®ããªããšãã«ããããµãªã³ã®è£œé ã«ãã®ãŸãŸäœ¿
çšã§ããã å®æœäŸ ïŒ ãããã®å®æœäŸã¯åçš®ã®èŠå ïŒã·ã¢ã³åç©ã®
éã溶åªã®å®¹ç©ãåå¿æž©åºŠåã³åå¿æéïŒã®ãã¹
âãã³ãŸã€ã³åéåã³ãã®ååç©ã®çŽåºŠã«åãŒã
圱é¿ã瀺ãããã®ãã®ã§ããã å®éšã¯ãã¬ãã¿ã«ã¢ã«ããã80ïœïŒ0.597ã¢ã«ïŒ
åã³ãã³ãºã¢ã«ããã250ïœïŒ2.36ã¢ã«ïŒãã¡ã¿
ããŒã«äžã«æº¶è§£ããŠå®æœããã次ãã§è¡šïŒã«ç€ºã
éã®ã·ã¢ã³åã«ãªãŠã ãå ããåè¡šã«ç€ºã枩床å
ã³æéã®è«žæ¡ä»¶ã«åŸã€ãŠåå¿ãè¡ã€ãã
ãè¡šã
ãè¡šã
溶åªã®å®¹ç©ã¯çæç©ã®çŽåºŠã«åœ±é¿ãåãŒããçŽ
床ã¯å®æœäŸïŒã12ïŒæº¶åªïŒïŒã«ãããŠã¯å°ãªã
ãšã99ïŒ ã§ãã€ãããå®æœäŸïŒåã³ïŒïŒæº¶åª0.4
ïŒã«ãããŠã¯95ïŒ ã«éããªãã€ãã å®æœäŸïŒïŒïŒïŒïŒïŒ10åã³12ã¯ããã¹âãã³ãŸ
ã€ã³åéãæ·»å ããã·ã¢ã³åç©ã®éãšåæã«å¢å
ããããšã瀺ããŠããã äžæ¹ã«ãããŠå®æœäŸïŒåã³ïŒãä»æ¹ã«ãããŠå®
æœäŸ10åã³11ãæ¯èŒããã°ãåå¿ã20âã«ãããŠ
è¡ã€ãæã®ã»ãããå šé¢çã«70âã«ãããŠè¡ã€ã
å Žåããããåéã倧ããããšã瀺ããŠããã å®æœäŸïŒãšïŒã®æ¯èŒã¯ãåå¿ãå§ãã«20âã«ã
ããŠã次ãã§70âã«ãããŠè¡ã€ãå Žåãåéãå
äžããããšã瀺ããŠããã å®æœäŸ 13ã16 å®æœäŸïŒã®æ¹æ³ã«åŸã€ãŠå®æœãããããã®å®æœ
äŸã¯éå°ã®ãã³ãºã¢ã«ãããã®ãã¹âãã³ãŸã€ã³
åéã«åãŒã圱é¿ã瀺ããã®ã§ããã å®éšã¯ãã¬ãã¿ã«ã¢ã«ããã80ïœãKCN12.5
ïœåã³è¡šïŒã«ç€ºãéã®ãã³ãºã¢ã«ããããã¡ã¿ã
ãŒã«ïŒã«æº¶è§£ããŠè¡ã€ããåå¿ã¯20âã«ãããŠ
ïŒæéã次ãã§70âã«ãããŠïŒæéè¡ã€ãã
床ã¯å®æœäŸïŒã12ïŒæº¶åªïŒïŒã«ãããŠã¯å°ãªã
ãšã99ïŒ ã§ãã€ãããå®æœäŸïŒåã³ïŒïŒæº¶åª0.4
ïŒã«ãããŠã¯95ïŒ ã«éããªãã€ãã å®æœäŸïŒïŒïŒïŒïŒïŒ10åã³12ã¯ããã¹âãã³ãŸ
ã€ã³åéãæ·»å ããã·ã¢ã³åç©ã®éãšåæã«å¢å
ããããšã瀺ããŠããã äžæ¹ã«ãããŠå®æœäŸïŒåã³ïŒãä»æ¹ã«ãããŠå®
æœäŸ10åã³11ãæ¯èŒããã°ãåå¿ã20âã«ãããŠ
è¡ã€ãæã®ã»ãããå šé¢çã«70âã«ãããŠè¡ã€ã
å Žåããããåéã倧ããããšã瀺ããŠããã å®æœäŸïŒãšïŒã®æ¯èŒã¯ãåå¿ãå§ãã«20âã«ã
ããŠã次ãã§70âã«ãããŠè¡ã€ãå Žåãåéãå
äžããããšã瀺ããŠããã å®æœäŸ 13ã16 å®æœäŸïŒã®æ¹æ³ã«åŸã€ãŠå®æœãããããã®å®æœ
äŸã¯éå°ã®ãã³ãºã¢ã«ãããã®ãã¹âãã³ãŸã€ã³
åéã«åãŒã圱é¿ã瀺ããã®ã§ããã å®éšã¯ãã¬ãã¿ã«ã¢ã«ããã80ïœãKCN12.5
ïœåã³è¡šïŒã«ç€ºãéã®ãã³ãºã¢ã«ããããã¡ã¿ã
ãŒã«ïŒã«æº¶è§£ããŠè¡ã€ããåå¿ã¯20âã«ãããŠ
ïŒæéã次ãã§70âã«ãããŠïŒæéè¡ã€ãã
ãè¡šã
ãããã®å®æœäŸãæ¯èŒãããšããã³ãºã¢ã«ãã
ãã®æé©ã®å²åã¯ååŠéè«éã®ïŒåè¿ãããŸãã
ã®éå°ãäœã倧ããè¶ ããã®ã¯æå©ã§ãªãããšã
瀺ããŠããã å®æœäŸ 17 ãã®æ¯èŒè©Šéšã¯ãåå¿ãïŒçžç³»ã«ãããŠã溶åª
ãçšããã«è¡ã€ãå Žåã«åŸãçµæã瀺ãããã®ã
ã®ã§ããã 極ããŠé«éã®æ¹æåšãåããåå¿åšå ã«ããã¬
ãã¿ã«ã¢ã«ããã80ïœããã³ãºã¢ã«ããã250mlã
æ°Ž1000mlãã·ã¢ã³åã«ãªãŠã 22ïœåã³å¡©åããªã«
ããªã«ã¢ã³ã¢ããŠã 65ïœãå ¥ãããæ··åç©ã宀枩
ã«ãããŠ20åé匷ãæ¹æãããææ©çžã沞隰ãšã¿
ããŒã«ã«æ°åæŽæµãã次ãã§éãã也ç¥ããã
çŽåºŠ90ïŒ ã®ãã¹âãã³ãŸã€ã³ã®åçã¯50ïŒ ã«éã
ãªãã€ãã å®æœäŸ 18 ãã®æ¯èŒè©Šéšã¯ã·ã¢ã³åã«ãªãŠã ã溶解ããªã
ææ©æº¶åªã®äœ¿çšã瀺ããã®ã§ããã ãã³ãŒã³ïŒäžã®ãã¬ãã¿ã«ã¢ã«ãããïŒ80
ïœïŒåã³ãã³ãºã¢ã«ãããïŒ250ïœïŒã®æº¶æ¶²ã匷
ãæ¹æããŠãããã«æ°Ž200mläžã®ã·ã¢ã³åã«ãªãŠ
ã ïŒ12.5ïœïŒæº¶æ¶²ãå ãã次ãã§å¡©åããªã«ããª
ã«ã¡ãã«ã¢ã³ã¢ããŠã 40ïœã®æ°Ž200mläžã®æº¶æ¶²ã
滎äžãããïŒæéã®æ¹æã®åŸãææ©çžãåŸçã
ãããã³ãŒã³ãæžæ¿ããŠããåºåœ¢ç©ããéã«ã
ã€ãŠåé¢ããããã®åºåœ¢ç©ã沞隰ãšã¿ããŒã«ã§ïŒ
åæŽæµããŠãçŽåºŠ92ïŒ ã®ãã¹âãã³ãŸã€ã³ã®35ïŒ
ããåŸãããªãã€ãã
ãã®æé©ã®å²åã¯ååŠéè«éã®ïŒåè¿ãããŸãã
ã®éå°ãäœã倧ããè¶ ããã®ã¯æå©ã§ãªãããšã
瀺ããŠããã å®æœäŸ 17 ãã®æ¯èŒè©Šéšã¯ãåå¿ãïŒçžç³»ã«ãããŠã溶åª
ãçšããã«è¡ã€ãå Žåã«åŸãçµæã瀺ãããã®ã
ã®ã§ããã 極ããŠé«éã®æ¹æåšãåããåå¿åšå ã«ããã¬
ãã¿ã«ã¢ã«ããã80ïœããã³ãºã¢ã«ããã250mlã
æ°Ž1000mlãã·ã¢ã³åã«ãªãŠã 22ïœåã³å¡©åããªã«
ããªã«ã¢ã³ã¢ããŠã 65ïœãå ¥ãããæ··åç©ã宀枩
ã«ãããŠ20åé匷ãæ¹æãããææ©çžã沞隰ãšã¿
ããŒã«ã«æ°åæŽæµãã次ãã§éãã也ç¥ããã
çŽåºŠ90ïŒ ã®ãã¹âãã³ãŸã€ã³ã®åçã¯50ïŒ ã«éã
ãªãã€ãã å®æœäŸ 18 ãã®æ¯èŒè©Šéšã¯ã·ã¢ã³åã«ãªãŠã ã溶解ããªã
ææ©æº¶åªã®äœ¿çšã瀺ããã®ã§ããã ãã³ãŒã³ïŒäžã®ãã¬ãã¿ã«ã¢ã«ãããïŒ80
ïœïŒåã³ãã³ãºã¢ã«ãããïŒ250ïœïŒã®æº¶æ¶²ã匷
ãæ¹æããŠãããã«æ°Ž200mläžã®ã·ã¢ã³åã«ãªãŠ
ã ïŒ12.5ïœïŒæº¶æ¶²ãå ãã次ãã§å¡©åããªã«ããª
ã«ã¡ãã«ã¢ã³ã¢ããŠã 40ïœã®æ°Ž200mläžã®æº¶æ¶²ã
滎äžãããïŒæéã®æ¹æã®åŸãææ©çžãåŸçã
ãããã³ãŒã³ãæžæ¿ããŠããåºåœ¢ç©ããéã«ã
ã€ãŠåé¢ããããã®åºåœ¢ç©ã沞隰ãšã¿ããŒã«ã§ïŒ
åæŽæµããŠãçŽåºŠ92ïŒ ã®ãã¹âãã³ãŸã€ã³ã®35ïŒ
ããåŸãããªãã€ãã
Claims (1)
- ãç¹èš±è«æ±ã®ç¯å²ã ïŒ ïŒ»ïŒœ ïœ ãã¬ãã¿ã«ã¢ã«ããããããã¯
ã€ãœãã¿ã«ã¢ã«ãããããååŠéè«ã®å²åã
ãäœãå²åã®ã¢ã«ã«ãªéå±ã®ã·ã¢ã³åç©ãšã
æ±ãããã¹âãã³ãŸã€ã³ãå®è³ªçã«æº¶è§£ãã
ããšãªããåèšãã¬ãã¿ã«ã¢ã«ãããããã
ã¯ã€ãœãã¿ã«ã¢ã«ãããåã³åèšã¢ã«ã«ãªé
å±ã·ã¢ã³åç©ãå®è³ªçã«æº¶è§£ãåŸã溶åªäžã«
ãããŠåå¿ããããããšã ïœ æº¶è§£åŸããã¬ãã¿ã«ã¢ã«ããããããã¯ã€
ãœãã¿ã«ã¢ã«ãããïŒã¢ã«ã«å¯ŸããŠïŒã¢ã«ä»¥
äžã®å²åã®ãã³ãºã¢ã«ãããã«ããã®ããã«
圢æããåå¿åªè³ªãïŒã30âã®æž©åºŠã«ãããŠ
åå¿ããããããšã ïœ åå¿åªè³ªã50ã150âã®æž©åºŠã«å ç±ããã
ãšãå«ãæ¹æ³ã«ãã€ãŠã åŒ ã«çžåœãããã¹âãã³ãŸã€ã³ããããã¯åŒ ã«çžåœãããã¹âãã³ãŸã€ã³ã 補é ããããšã  圢æããããã¹âãã³ãŸã€ã³ãåé¢ãã
ããšãå㳠 ãããé žåããŠæ±ãããã¹âïŒããšãã«
ã°ãªãªãã·ãã€ã«ïŒãã³ãŒã³ã«ããããšãç¹åŸŽ
ãšãããé«çŽåºŠã®ïŒïŒïŒâãã¹âïŒããšãã«ã°
ãªãªãã·ãã€ã«ïŒãã³ãŒã³åã¯ïŒïŒïŒâãã¹â
ïŒããšãã«ã°ãªãªãã·ãã€ã«ïŒãã³ãŒã³ã®è£œé
æ³ã ïŒ çšãã溶åªãïŒãïŒåã®ççŽ ååãæããè
èªæâ䟡ã¢ã«ã³ãŒã«ããæã€ãŠããããšãç¹åŸŽãš
ãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé èšèŒã®æ¹æ³ã ïŒ æº¶åªããã¬ãã¿ã«ã¢ã«ããããããã¯ã€ãœã
ã¿ã«ã¢ã«ãããïŒã¢ã«ã«å¯ŸããŠïŒãïŒã®å²åã§
çšããããšãç¹åŸŽãšãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé
åã¯ç¬¬ïŒé èšèŒã®æ¹æ³ã ïŒ å·¥çš(a)ã«ãããã¢ã«ã«ãªéå±ã·ã¢ã³åç©ã®å²
åããã¬ãã¿ã«ã¢ã«ããããããã¯ã€ãœãã¿ã«ã¢
ã«ãããïŒã¢ã«ã«å¯ŸããŠ0.3ãïŒã¢ã«ã§ããããš
ãç¹åŸŽãšãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé ãã第ïŒé
ãŸã§ã®ããããïŒé ã«èšèŒã®æ¹æ³ã ïŒ ã¢ã«ã«ãªéå±ã·ã¢ã³åç©ãã·ã¢ã³åã«ãªãŠã
ã§ããããšãç¹åŸŽãšãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé
ãã第ïŒé ãŸã§ã®ããããïŒé ã«èšèŒã®æ¹æ³ã ïŒ å·¥çš(b)ã«ãããŠããã³ãºã¢ã«ãããã®å²åã
ãã¬ãã¿ã«ã¢ã«ããããããã¯ã€ãœãã¿ã«ã¢ã«ã
ããïŒã¢ã«ã«å¯ŸããŠ3.6ãïŒã¢ã«ã§ããããšãç¹
城ãšãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé ãã第ïŒé ãŸã§
ã®ããããïŒé ã«èšèŒã®æ¹æ³ã ïŒ ïŒã30âã®æž©åºŠã«ãããŠè¡ãå·¥çš(b)ã®æç¶æ
éã0.5ãïŒæéã§ããã50ã150âã®æž©åºŠã«ãã
ãŠè¡ãæäœ(c)ã®æç¶æéãïŒã10æéã§ããããš
ãç¹åŸŽãšãããç¹èš±è«æ±ã®ç¯å²ç¬¬ïŒé ãã第ïŒé
ãŸã§ã®ããããïŒé ã«èšèŒã®æ¹æ³ã ïŒ äžéã«ãããŠåœ¢æããããã¹âãã³ãŸã€ã³
ããé ¢é žé åã³ç¡é žã¢ã³ã¢ããŠã ãå«ãé žåå€ã
çšããŠé žåãããããšãç¹åŸŽãšãããç¹èš±è«æ±ã®
ç¯å²ç¬¬ïŒé ãã第ïŒé ãŸã§ã®ããããïŒé ã«èšèŒ
ã®æ¹æ³ã
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7913424A FR2457274A1 (fr) | 1979-05-23 | 1979-05-23 | Procede ameliore de synthese de bis-(phenylglyoxyloyl) benzenes, utilisables dans la preparation de resines polyphenylquinoxalines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS55157533A JPS55157533A (en) | 1980-12-08 |
| JPS6323979B2 true JPS6323979B2 (ja) | 1988-05-18 |
Family
ID=9225886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP6951280A Granted JPS55157533A (en) | 1979-05-23 | 1980-05-23 | Manufacture of high purity biss*phenylglyoxyloyl*benzene |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4310699A (ja) |
| JP (1) | JPS55157533A (ja) |
| DE (1) | DE3019500A1 (ja) |
| FR (1) | FR2457274A1 (ja) |
| GB (1) | GB2054559B (ja) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8512998D0 (en) * | 1985-05-22 | 1985-06-26 | Ciba Geigy Ag | Production of images |
| WO2016153905A1 (en) | 2015-03-20 | 2016-09-29 | University Of Houston System | Cyclobenzoins |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024067A (en) * | 1976-01-07 | 1977-05-17 | The United States Of America As Represented By The Secretary Of The Navy | Processes for the preparation of bis-benzoins and bis-benzils |
-
1979
- 1979-05-23 FR FR7913424A patent/FR2457274A1/fr active Granted
-
1980
- 1980-05-22 GB GB8016875A patent/GB2054559B/en not_active Expired
- 1980-05-22 DE DE19803019500 patent/DE3019500A1/de active Granted
- 1980-05-23 JP JP6951280A patent/JPS55157533A/ja active Granted
- 1980-05-23 US US06/152,895 patent/US4310699A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| FR2457274B1 (ja) | 1984-02-10 |
| DE3019500A1 (de) | 1980-11-27 |
| US4310699A (en) | 1982-01-12 |
| FR2457274A1 (fr) | 1980-12-19 |
| GB2054559B (en) | 1983-09-07 |
| GB2054559A (en) | 1981-02-18 |
| JPS55157533A (en) | 1980-12-08 |
| DE3019500C2 (ja) | 1989-08-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPH04250854A (ja) | ã¡ã¿ã¯ãã¬ã€ã³ã®æ°çžé žåã«ããã¡ã¿ã¯ãªã«é žè£œé çšã®è§Šåªçµæç© | |
| JP4540761B2 (ja) | è³éŠæååç©ã®ããããã·è³éŠæååç©ãžã®é žåæ¹æ³ | |
| JPS6323979B2 (ja) | ||
| WO1993002046A1 (en) | Process for producing nitrile | |
| JPS6222740A (ja) | ïœâããããã·ãã³ãºã¢ã«ãããã®åé¢æ³ | |
| JPH11228490A (ja) | ïŒïŒïŒââãã¹ïŒããããã·ã¡ãã«ïŒã¢ã«ã«ã³é žã®è£œé æ¹æ³ | |
| US5648551A (en) | Process for the preparation of halobenzaldehydes | |
| CN109776295B (zh) | äžç§é»äœå«äºæ°äºç²åºçè³åºç¢ååç©åå¶å€æ¹æ³ | |
| US4235807A (en) | Synthesis of 2,6-disubstituted benzonitriles | |
| US4146582A (en) | Process for preparing aromatic aldehydes and ketones | |
| JP3461014B2 (ja) | ããã©ãã¹ïŒããããã·ãã§ãã«ïŒã¢ã«ã«ã³ã®è£œé æ¹æ³ | |
| US6933405B2 (en) | User- and eco-friendly hypervalent iodine reagent and method of synthesis | |
| JP2002220373A (ja) | ïŒâïŒïŒâããªãžã«ïŒãšã¿ã³ããªãŒã«ã®è£œé æ¹æ³ | |
| JP2002179608A (ja) | ãã¿ã«ã¢ã«ãããã®è£œé æ¹æ³ | |
| US4146735A (en) | Preparation of α,β-unsaturated carboxylic acids via Mannich intermediates | |
| US5214192A (en) | Process for preparing iodoarene compounds | |
| JP3031851B2 (ja) | ã¢ã«ã³ãŒã«é¡ã®è£œé æ¹æ³ | |
| US3595922A (en) | Benzil preparation | |
| JPH0327549B2 (ja) | ||
| JPH05508416A (ja) | ãžã±ãã³åã³ã±ãé žã®è£œé æ¹æ³ | |
| WO1990009975A1 (en) | Aldehyde oxidation | |
| JPH11228489A (ja) | ïŒïŒïŒââãã¹ïŒããããã·ã¡ãã«ïŒã¢ã«ã«ã³é žã®è£œé æ¹æ³ | |
| JPS6137753A (ja) | ã±ã€ç®ã¢ã«ãããã®é žåæ¹æ³ | |
| JPS6245555A (ja) | æ¡ç®é žé¡ã®è£œé æ³ | |
| JP2002212149A (ja) | ããåããã©ã¢ã«ãã«ã¢ã³ã¢ããŠã ã®è£œé æ¹æ³ãããã³ãããçšããβâããããã·ã±ãã³ã®è£œé æ¹æ³ |