JPS6325564B2 - - Google Patents

Description

[Detailed description of the invention]

The present invention relates to a water-soluble solid detergent for cleaning dentures,
In particular, the present invention relates to a water-soluble solid detergent that fully utilizes the effects of bubbles, active oxygen, and enzymes to enhance the cleaning effect of dentures. A commonly used denture cleaner is a tablet-type denture cleaner containing citric acid or tartaric acid mixed with sodium bicarbonate. When these are dissolved in water, they react with each other and generate carbon dioxide bubbles, which can be used for mechanical cleaning by floating flow. exerts its effect. However, since a sufficient cleaning effect cannot be obtained with the mechanical cleaning action of foaming alone, active oxygen-generating substances such as potassium persulfate and sodium persulfate are added to the cleaning agent to utilize the bactericidal effect of active oxygen. Proposals have also been made to improve the cleaning effect. Furthermore, in 1977-
Publication No. 38415 also proposes a tablet-type detergent in which an enzyme layer in the form of an effervescent composition and an active oxygen layer in the form of an effervescent composition are laminated. This cleaning agent is expected to have a biochemical purification effect due to enzymes in addition to the mechanical cleaning effect due to foaming and the sterilizing effect due to active oxygen, and prevents enzymes from being deactivated by active oxygen during storage. For this purpose, these are provided as a laminated structure divided into layers. Furthermore, according to the publication, in order to prevent the enzyme from deactivating during use and to effectively exert the purification effect of the enzyme, the formulation method and raw materials must be adjusted so that the enzyme layer dissolves faster than the active oxygen layer. It was necessary to make adjustments, which caused problems in terms of formulation workability and cost. The present inventors have also been conducting research to improve denture cleaning agents for some time, and have focused in particular on the purifying effects of the foaming agent, active oxygen, and enzymes, and have been conducting research to make these effects more effective. However, as a result, solid detergents that are mixed with an enzyme protectant and made into granules or powder, and then mixed uniformly with a foaming agent and an active oxygen generating agent have been found to have a lower enzyme activity during storage. The present invention has been completed by confirming the fact that the compound is maintained at a high level and exhibits an extremely excellent purifying effect after being dispersed and dissolved in water. That is, the water-soluble solid detergent for cleaning dentures according to the present invention is a mixture of an enzyme mixed with a protective agent and made into granules or powder, an effervescent substance and an active oxygen generating substance, and mixed together. It has a gist. As stated in the above-mentioned publication, enzyme activity is reduced or deactivated by active oxygen, so it is of course necessary to maintain them in a non-contact state during the storage period, and at the time of use. In order to effectively demonstrate the action of the enzyme, the enzyme must be dissolved quickly when added to water, and the active oxygen generating substances must be dissolved late, so that the purifying action of the enzyme can be exerted before active oxygen is generated. Therefore, as mentioned above, the formulation technology had to be improved. However, with this approach, although the decline in enzyme activity during storage can be suppressed, the time during which the enzyme's action is effectively exerted is the very short time from when the enzyme is dissolved until active acids are generated. Considering the characteristics of enzyme reactions, it is difficult to say that the purifying action of enzymes is fully utilized. On the other hand, the inventors have confirmed through experiments that if the enzyme is mixed with a protective agent such as the one described below and made into granules or powder, the activity of the enzyme can be maintained stably during storage in tablets, etc. In addition, even when used together with active oxygen substances, it will not be deactivated for a while, and even when enzymes and active oxygen generating substances are dissolved at the same time, the purification effects of both will be effectively exerted. I've come to a conclusion. That is, when the solid detergent of the present invention is poured into water,
The effervescent substance, the active oxygen generating substance, and the enzyme dissolve almost simultaneously, and the effervescent substance and the active oxygen generating substance exert a purifying effect immediately after dissolution, and lose their effect within a relatively short period of time (the end of foaming). On the other hand, enzymes dissolve with a delay due to the action of the protective agent, so they do not show any activity in the initial period when they are added to water, and the action of active oxygen generating substances is reduced or lost. At some point, the enzyme gradually begins to dissolve and exhibit enzyme activity, and the enzyme's action continues thereafter, biochemically purifying the substances that cannot be purified by effervescent substances and active oxygen generating substances. Demonstrate function. Therefore, extremely high purification effects can be obtained. The foaming substance used in the present invention refers to a substance that reacts to generate carbon dioxide or oxygen gas when added to water, and includes a mixture of carbonate and acid, peroxide, and the like. Examples of carbonates include carbonates or hydrogen carbonates of alkali metals (Na, K, Li, etc.), carbonates or hydrogen carbonates of rubidium, and examples of acids include citric acid, tartaric acid, or mixtures thereof. Although this is the most common, acidic phosphates of alkali metals and the like can also be used. Examples of active oxygen generating substances include peroxides such as sodium (or potassium) perborate and sodium (or potassium) persulfate. Examples of enzymes include protease, amylase, papain, revertase, dextranase, etc., and these can be used alone or in combination of two or more. These enzymes are mixed with a protective agent such as milk powder, gelatin, or polyvinyl alcohol to form a powder, or mixed with a small amount of polyethylene glycol and the like and dried through ventilation to be used in the form of granules or powder. As mentioned above, these protective agents prevent enzymes from coming into contact with active oxygen generating substances during storage as tablets, etc., thereby preventing enzyme deactivation, and also delay dissolution of enzymes when placed in water during use. It has the function of maximizing the effectiveness of enzyme activity by acting as an agent and causing enzyme activity to occur only after the action of active oxygen is reduced or lost. The above-mentioned foamable substances, active oxygen generating substances, and enzymes can be uniformly mixed in the form of granules using an appropriate water-soluble binder or water-soluble lubricant, or can be uniformly mixed in the form of powder or granules. It is then molded into tablets and provided. When blending these products, fillers, extenders, lubricants, bleaching agents, buffering agents, dyes, fragrances, etc. can be added as necessary. It is also effective to blend glycine or the like, or to blend a small amount of an antifoaming agent to eliminate floating bubbles. The blending ratio of the above three essential components is not particularly limited, but in order to more effectively exhibit the cleaning effect of each component or to exhibit a complementary cleaning effect, it is recommended that the foaming substance be 10 to 50% (compound (wt% to total amount: same below), 5 to 30% of active oxygen generating substance, 1% of enzyme
It is best to set it in the range of ~15%. The present invention is roughly configured as described above, and by mixing the enzyme with a protective agent in a granular or powdered state and uniformly mixing it with an effervescent substance and an active oxygen generating substance, storage stability can be improved. At the same time, the mechanical cleaning effect of foaming, the sterilizing cleaning effect of active oxygen, and the biochemical cleaning effect of enzymes are exerted in an additive or complementary manner, ensuring an excellent overall cleaning effect. Ta. Next, examples of the present invention will be shown, but the present invention is not limited to the following, and the types, combinations, and blending ratios of the ingredients may be changed as appropriate within the scope of the above and below objectives. All that is within the scope of this invention. Example 1 Using the raw materials shown in Table 1, a tablet-shaped cleaning agent was manufactured according to the method described below. [Preparation of blowing agent] Melt the organic acid, add sodium carbonate to it, mix uniformly, cool and dry, and grind to about 80 to 100 meshes. When adding glycine (foam refiner), adjust the particle size to the same as above and mix. [Enzyme granulation] Enzyme and a small amount of protective agent (milk powder and gelatin) are mixed, added to polyethylene glycol and dissolved uniformly, and then the protective agent is added while stirring to form granules. Next, the material is dried with ventilation until the moisture content is reduced to about 0.5% or less, and then pulverized to about 80 to 100 meshes. [Manufacture of solid detergent] The granular foaming agent and protected enzyme-containing granules obtained above are mixed with peroxide, a stabilizer (sodium tripolyphosphate), and a PH adjuster ( whose particle size is adjusted to 80 to 100 mesh or less). The mixture was uniformly mixed with sodium metasilicate, trisodium phosphate), a surfactant (sodium lauryl sulfate, sucrose ester), a coloring matter, and a flavoring agent, and then tableted according to a conventional method.

[Table] In Table 1, codes 1 and 4 use enzymes that are active on the alkaline side. Adjust the amount of ingredients, and also
and 3 use enzymes that are active in the neutral range, so the solution after being added to water is neutral (PH6.5-7.5)
The amounts of acid and alkali components were adjusted to show the following. When 3.0 g of each tablet obtained above was added to 150 ml of distilled water and the dissolution time and PH change after addition were examined, the results shown in Figure 1 were obtained. [Cleaning test] Each of the cleaning agents obtained above was used on a test plate (the floor of only the roof of the mouth made using instantly polymerizable resin) that was worn in the oral cavity of 40 subjects for 45 hours. The following tests were conducted. That is, one set consisted of eight test plates, and five sets were prepared. The above-mentioned plate was immersed in a container containing 150 ml of water, and the cleaning effect was evaluated with water alone and with 3.0 g of each of tablets 1 to 4 added thereto. The cleaning effect was determined by collecting plaque adhered to the test plate little by little over time with a sterilized cotton swab, inoculating it on a Schare plate on Sabouraud agar medium, and checking the number of bacterial colonies after 48 hours. Bacterial survival rate was determined from the rate of decrease in the number of each colony when the number of colonies immediately before immersion was set as 100. As a result, the bacterial survival rate was approximately 90% even after 2 hours with the water-only cleaning solution, but the bacterial survival rate dropped to almost zero after 30 minutes of immersion in the cleaning solution containing tablets numbered 1 to 4. Ta. Example 2 According to the formulation shown in code 1 of Table 1, the blending ratio of effervescent substance (tartaric acid + sodium bicarbonate), peroxide (sodium perborate), enzyme (alkaline protease), and other ingredients Three types of tablets were prepared in the same manner as in Example 1, except that the values were changed as shown in Table 2, and the bacterial survival rate over time was examined for each tablet in the same manner as above.

[Table] (Weight%)
The results are shown in Figure 2. As is clear from FIG. 2, water alone hardly reduces the bacterial survival rate and cannot achieve the purpose of cleaning. Reference numeral A is a comparative example in which no enzyme was added, and even if the washing time was sufficiently long, the bacterial survival rate could not be reduced to zero. Reference numeral B is a comparative example in which no peroxide was added, and it took a relatively long time to reduce the bacterial survival rate to zero. On the other hand, code C is an example that satisfies the requirements of the present invention, and it is understood that the bacterial survival rate can be reduced to zero in a short time of about 30 minutes, and an excellent cleaning effect is exhibited.

[Brief explanation of the drawing]

FIG. 1 is a graph showing the PH change when the solid cleaning agent of the present invention is added to water, and FIG. 2 is a graph showing the relationship between cleaning time and bacterial survival rate.

Claims (1)

[Claims] 1. A water-soluble solid detergent for cleaning dentures, characterized in that the enzyme is mixed with a protective agent to form granules or powder, and a foaming substance and an active oxygen generating substance are uniformly mixed therein.